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https://www.readbyqxmd.com/read/29710029/gender-difference-and-dietary-supplemental-vitamin-b-6-impact-on-colon-luminal-environment
#1
Dwi Eva Nirmagustina, Yongshou Yang, Thanutchaporn Kumrungsee, Noriyuki Yanaka, Norihisa Kato
Colon diseases can be affected by several factors such as gender difference and dietary supplemental vitamin B6 (B6 ). The nutritional status of B6 is affected by gender difference, leading us to hypothesize that gender difference affects colon luminal environment, which is dependent on B6 status. To investigate this hypothesis, we fed male and female rats a diet containing 1 mg, 7 mg, or 35 mg pyridoxine HCl/kg diet for 6 wk. We found significantly higher fecal mucin levels in female rats compared to those in male rats...
2018: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29700769/clinical-characteristics-of-two-cohorts-of-infantile-spasms-response-to-pyridoxine-or-topiramate-monotherapy
#2
Jiao Xue, Ping Qian, Hui Li, Ye Wu, Hui Xiong, Yue-Hua Zhang, Zhi-Xian Yang
BACKGROUND: Infantile spasms (IS) was an epileptic disease with varied treatment widely among clinicians. Here, we aimed to compare and analyze the clinical characteristics of IS response to pyridoxine or topiramate monotherapy (TPM control IS). METHODS: The clinical manifestations, treatment processes and outcomes were analyzed in 11 pyridoxine responsive IS and 17 TPM-control IS. RESULTS: Of the 11 patients with pyridoxine responsive IS, nine were cryptogenic/idiopathic...
April 26, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29670171/author-correction-pyridoxine-dipharmacophore-derivatives-as-potent-glucokinase-activators-for-the-treatment-of-type-2-diabetes-mellitus
#3
Mikhail S Dzyurkevich, Denis A Babkov, Nikita V Shtyrlin, Olga Yu Mayka, Alfiya G Iksanova, Pavel M Vassiliev, Konstantin V Balakin, Alexander A Spasov, Vadim V Tarasov, George Barreto, Yurii G Shtyrlin, Gjumrakch Aliev
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29665762/effects-of-vitamin-b6-pyridoxine-and-a-b-complex-preparation-on-dreaming-and-sleep
#4
Denholm J Aspy, Natasha A Madden, Paul Delfabbro
Anecdotal evidence indicates that supplementation with vitamin B6 (pyridoxine) before bed can enhance dream vividness and recall. In a single pilot study, Ebben, Lequerica, and Spielman (2002) found that vitamin B6 had a dose-dependent effect of increasing scores on a composite measure of dream vividness, bizarreness, emotionality, and color. The present research replicated this study using a larger and more diverse sample of 100 participants from across Australia. We conducted a randomized, double-blind, placebo-controlled investigation of the effects on dreaming and sleep of ingesting 240 mg vitamin B6 (pyridoxine hydrochloride) before bed for five consecutive days...
January 1, 2018: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/29661537/pyridoxine-dependent-epilepsy-is-late-onset-a-predictor-for-favorable-outcome
#5
Rooy Rlp de, F J Halbertsma, E A Struijs, Spronsen Fj van, R J Lunsing, H M Schippers, Hasselt Pm van, B Plecko, G Wohlrab, S Whalen, J F Benoist, S Valence, P B Mills, L A Bok
AIM: In pyridoxine dependent epilepsy (PDE), patients usually present with neonatal seizures. A small subgroup is characterized by late-onset beyond 2 months of age. We aim to analyze the observation of relatively good cognitive outcome in this subgroup of late-onset PDE patients. METHODS: We retrospectively analyzed data from four metabolically and genetically confirmed late-onset patients with PDE due to antiquitin (ALDH7A1) deficiency. Data were analyzed regarding ALDH7A1 mutations, alpha-Aminoadipic semialdehyde (α-AASA) and pipecolic acid (PA) levels, medication during pregnancy, delivery, treatment delay, amount of seizures, pyridoxine dose, adjuvant therapy and findings on brain MRI...
March 30, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29661461/urgent-living-donor-liver-transplantation-in-a-patient-with-concurrent-active-tuberculosis-a-case-report
#6
B-H Jung, J-I Park, S-G Lee
BACKGROUND: Although active tuberculosis (TB) is considered a contraindication for liver transplantation (LT), this is the only treatment in patients with liver failure and concurrent active TB. We report a case with successful urgent living-donor LT for irreversible liver failure in the presence of active TB. CASE PRESENTATION: A 48-year-old man, with a history of decompensated alcoholic liver cirrhosis, was presented with stupor. At admission, his consciousness had deteriorated to semi-coma, and his renal function also rapidly deteriorated to hepatorenal syndrome...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29649987/multimodal-imaging-of-foveoschisis-and-macular-pseudohole-associated-with-gyrate-atrophy-a-family-report
#7
Imène Zhioua Braham, Imen Ammous, Rim Maalej, Majdi Boukari, Ilhem Mili Boussen, Khalil Errais, Raja Zhioua
BACKGROUND: To report the results of multimodal imaging of a biochemically confirmed case of a family with gyrate atrophy (GA) associated with foveoschisis and macular pseudohole. CASE PRESENTATION: Two sisters presented to us with progressive bilateral decreased vision. The 26-year old sister had a best corrected visual acuity (BCVA) of 20/32 in the right eye (RE) and 20/100 in the left eye (LE). Dilated fundus examination revealed multiple bilateral chorioretinal atrophy areas in the midperipheral and peripheral retina...
April 12, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29610166/b-6-and-bleeding-a-case-report-of-a-novel-vitamin-toxicity
#8
Alexandra J Borst, Dmitry Tchapyjnikov
Pyridox(am)ine-5-phosphate oxidase deficiency is an inborn error of vitamin B6 metabolism that is characterized by neonatal seizures, requiring lifelong therapy with pyridoxal-5-phosphate. We present the first case of a patient with pyridox(am)ine-5-phosphate oxidase deficiency and mild hemophilia A, whose bleeding symptoms were exacerbated by the vitamin B6 therapy essential for his epileptic disorder. This report expands the spectrum of known vitamin B6 toxicity and demonstrates a need for vigilance in monitoring for bleeding symptoms in patients requiring pyridoxine or pyridoxal-5-phosphate supplementation...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29579435/isoniazid-induced-early-onset-of-motor-dominant-neuropathy-and-treatment-with-high-dose-of-pyridoxine
#9
C R Choudhary, Jyoti Kumari, Manish Advani
No abstract text is available yet for this article.
April 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29572951/effect-of-heat-treatment-on-4-o-methylpyridoxine-mpn-content-in-ginkgo-biloba-seed-extract-solution
#10
Heung-Bin Lim, Dong-Ho Kim
BACKGROUND: A vitamin B6 derivative, 4'-O-methylpyridoxine (MPN), is responsible for food poisoning by Ginkgo biloba seeds. In this study, we investigate the content of pyridoxine and MPN in MPN standard solution and G. biloba seed extract solution upon heat treatment in order to evaluate the reduction of toxic components in G. biloba seed by such treatment. RESULTS: Heat treatment was conducted at 90-150 °C for 0-60 min, and all samples were adjusted to the same concentration of 1 g L-1 ...
March 24, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29565150/micronutrient-intake-in-elderly-living-in-nursing-homes
#11
Bruno Santos Assis, Jairza Maria Barreto-Medeiros Jairza, Jamile Almeida Lopes, Ana Karla Carneiro Roriz, Adriana Lima Melo, Agatha Previdell, Rita De Cássia Aquino, Lilian Barbosa Ramos
OBJECTIVE: The aim of this study was to evaluate the ingestion of micronutrients in elderly living in nursing homes. METHODS: This is a cross-sectional study, conducted with 216 individuals of both sexes, age equal or greater than 60 years, living in nursing homes for elderly in Salvador, Bahia, Brazil. Direct weighing of the food was used to get food intake, and prevalence of inadequacy was obtained using the software Multiple Source Method (MSM) and evaluated by estimated average requirement (EAR)...
February 13, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29552155/the-effects-of-vitamin-b-6-compounds-on-cell-proliferation-and-melanogenesis-in-b16f10-melanoma-cells
#12
Taisuke Matsuo, Aki Fujiwara, Kazuhiro Nakamura, Yasuyuki Sadzuka
B16F10 murine melanoma cells are frequently used for the study of cancer and melanogenesis. The cells are usually cultured in Dulbecco's Modified Eagle Medium, with the addition of 20 µM pyridoxal (PL) or pyridoxine (PN) for vitamin B6 . The difference between these vitamin B6 compounds is thought not to affect cell proliferation, whereas their influence on other physiological effects is poorly understood. In the present study, the effects of PL and PN on cell proliferation and melanogenesis in B16F10 cells were compared...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29548777/corrigendum-to-pyridoxine-5-phosphate-oxidase-pnpo-deficiency-clinical-and-biochemical-alterations-associated-with-the-c-347g-a-p-%C3%A2-arg116gln-mutation-mol-genet-metab-122-1-2-2017-135-142
#13
Martino L di Salvo, Mario Mastrangelo, Isabel Nogués, Manuela Tolve, Alessandro Paiardini, Carla Carducci, Davide Mei, Martino Montomoli, Angela Tramonti, Renzo Guerrini, Roberto Contestabile, Vincenzo Leuzzi
No abstract text is available yet for this article.
March 14, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29547829/atypical-pyridoxine-dependent-epilepsy-resulting-from-a-new-homozygous-missense-mutation-in-aldh7a1
#14
Zahraa Haidar, Nadine Jalkh, Sandra Corbani, Ali Fawaz, Eliane Chouery, André Mégarbané
Pyridoxine dependent epilepsy (PDE) is a rare autosomal recessive neurometabolic disorder. In the classical form, seizures are observed within the first month of life, while in the atypical form seizures appear later in life, sometimes as late as at the age of 3 years of life. Both types are unresponsive to conventional anticonvulsant therapy, but can be controlled with pyridoxine monotherapy. Mutations in the ALDH7A1 gene, encoding α-aminoadipic semialdehyde dehydrogenase have been reported to cause this disease in most patients...
April 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29547159/addition-of-pyridoxine-to-prednisolone-in-the-treatment-of-infantile-spasms-a-pilot-randomized-controlled-trial
#15
Vedavathi Kunnanayaka, Puneet Jain, Suvasini Sharma, Anju Seth, Satinder Aneja
Background: West syndrome is a catastrophic epilepsy syndrome characterized by infantile spasms, hypsarrhythmia, and developmental arrest or regression. Aim: The aim of this study was to explore the role of pyridoxine in the management of infantile spasms. Setting and Design: This was a pilot, randomized, open-label trial conducted at a tertiary level hospital from November 2012 to March 2014. Materials and Methods: Children aged 3 months to 3 years presenting with infantile spasms in clusters (at least 1 cluster/day) with hypsarrhythmia or its variants on electroencephalogram (EEG) were enrolled...
March 2018: Neurology India
https://www.readbyqxmd.com/read/29547149/role-of-pyridoxine-in-the-management-of-infantile-spasms
#16
EDITORIAL
Sangeeta Ravat, Mansi Shah
No abstract text is available yet for this article.
March 2018: Neurology India
https://www.readbyqxmd.com/read/29508359/eight-novel-mutations-of-cbs-gene-in-nine-chinese-patients-with-classical-homocystinuria
#17
Dong-Xiao Li, Xi-Yuan Li, Hui Dong, Yu-Peng Liu, Yuan Ding, Jin-Qing Song, Ying Jin, Yao Zhang, Qiao Wang, Yan-Ling Yang
BACKGROUND: Classical homocystinuria (homocysteinemia type 1, MIM# 236200) is a rare inherited disorder in Mainland China. This study aimed to identify mutations in the cystathionine β-synthase (CBS) gene which are associated with classical homocystinuria in nine Chinese patients. METHODS: Nine Chinese patients were diagnosed at the age of 5 years 4 months to 18 years by plasma total homocysteine and blood methionine determination. CBS gene analysis was performed for the patients and their families...
April 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29500614/expression-and-characterization-of-glutamate-decarboxylase-from-lactobacillus-brevis-hye1-isolated-from-kimchi
#18
Hee Seon Lim, Dong-Ho Seo, In-Tae Cha, Hyunjin Lee, Young-Do Nam, Myung-Ji Seo
A putative gene (gadlbhye1) encoding glutamate decarboxylase (GAD) was cloned from Lactobacillus brevis HYE1 isolated from kimchi, a traditional Korean fermented vegetable. The amino acid sequences of GADLbHYE1 showed 48% homology with the GadA family and 99% identity with the GadB family from L. brevis. The cloned GADLbHYE1 was functionally expressed in Escherichia coli using inducible expression vectors. The expressed recombinant GADLbHYE1 was successfully purified by Ni-NTA affinity chromatography, and had a molecular mass of 54 kDa with optimal hydrolysis activity at 55 °C and pH 4...
March 2, 2018: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29495635/the-postprandial-anti-hyperglycemic-effect-of-pyridoxine-and-its-derivatives-using-in-vitro-and-in-vivo-animal-models
#19
Hyuk Hwa Kim, Yu-Ri Kang, Jung-Yun Lee, Hung-Bae Chang, Ki Won Lee, Emmanouil Apostolidis, Young-In Kwon
In the current study, we investigated the inhibitory activity of pyridoxine, pyridoxal, and pyridoxamine, against various digestive enzymes such as α-glucosidases, sucrase, maltase, and glucoamylase. Inhibition of these enzymes involved in the absorption of disaccharide can improve post-prandial hyperglycemia due to a carbohydrate-based diet. Pyridoxal (4.14 mg/mL of IC50 ) had the highest rat intestinal α-glucosidase inhibitory activity, followed by pyridoxamine and pyridoxine (4.85 and 5.02 mg/mL of IC50 , respectively)...
February 28, 2018: Nutrients
https://www.readbyqxmd.com/read/29483806/evaluation-of-two-non-myasthenic-patients-with-ptosis
#20
Serkan Kırık, Olcay Güngör, Sedat Işıkay, Can Acıpayam, Yasemin Çoban, Emre Çelik
Decreased height of the eyelid or the narrowing of the lid is called ptosis. Ptosis has several causes. Malignancy-related conditions such as Horner's syndrome, which causes unilateral ptosis in the pediatric age group, and patients with malignancy receiving chemotherapeutic treatment, are often secondary to these drugs and ptosis is a clue of underlying diseases. Underlying pathologies can lead to different clinical conditions such as cognitive impairment from coma, the presence of ptosis should be cautionary...
December 2017: Türk Pediatri Arşivi
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