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https://www.readbyqxmd.com/read/27921103/solanesol-induces-the-expression-of-heme-oxygenase-1-via-p38-and-akt-and-suppresses-the-production-of-proinflammatory-cytokines-in-raw264-7-cells
#1
Xiangyang Yao, Binyu Lu, Chaotian Lü, Qin Bai, Dazhong Yan, Yanli Wu, Zibing Hong, Hui Xu
The aim of the present study was to examine the anti-inflammatory effect of solanesol and to elucidate the underlying mechanisms. Heme oxygenase-1 (HO-1) plays an important role in cytoprotection against oxidative stress and inflammation. Solanesol induced HO-1 expression both at the level of mRNA and proteins, resulting in increased HO-1 activity. Solanesol treatment enhanced the level of the phosphorylated form, nuclear translocation, ARE-binding, and transcriptional activity of Nrf2. p38 and Akt contributed to ARE-driven HO-1 expression...
December 6, 2016: Food & Function
https://www.readbyqxmd.com/read/27909560/induction-of-heme-oxygenase-1-with-dietary-quercetin-reduces-obesity-induced-hepatic-inflammation-through-macrophage-phenotype-switching
#2
Chu-Sook Kim, Hye-Seon Choi, Yeonsoo Joe, Hun Taeg Chung, Rina Yu
BACKGROUND/OBJECTIVES: Obesity-induced steatohepatitis accompanied by activated hepatic macrophages/Kupffer cells facilitates the progression of hepatic fibrinogenesis and exacerbates metabolic derangements such as insulin resistance. Heme oxyganase-1 (HO-1) modulates tissue macrophage phenotypes and thus is implicated in protection against inflammatory diseases. Here, we show that the flavonoid quercetin reduces obesity-induced hepatic inflammation by inducing HO-1, which promotes hepatic macrophage polarization in favor of the M2 phenotype...
December 2016: Nutrition Research and Practice
https://www.readbyqxmd.com/read/27904663/t-type-calcium-channel-blocker-attenuates-unilateral-ureteral-obstruction-induced-renal-interstitial-fibrosis-by-activating-the-nrf2-antioxidant-pathway
#3
Sungjin Chung, Soojeong Kim, Minyoung Kim, Eun Sil Koh, Hye Eun Yoon, Ho-Shik Kim, Cheol Whee Park, Yoon Sik Chang, Seok Joon Shin
Besides its effect on high blood pressure, T-type calcium channel blocker is renoprotective in experimental models of renal fibrosis. However, the exact mechanism of T-type calcium channel blocker on tubulointerstitial fibrosis is unclear. We investigated whether the renoprotective effect of T-type calcium channel blocker is associated with modulation of the signaling of oxidative stress-induced renal fibrosis. Treatment with a non-hypotensive dose of efonidipine, a T-type calcium channel blocker, or nifedipine, an L-type channel blocker, was initiated one day before unilateral ureteral obstruction (UUO) in C57BL6/J mice, and was continued until 3 and 7 days after UUO...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27895643/azithromycin-attenuates-pseudomonas-induced-lung-inflammation-by-targeting-bacterial-proteins-secreted-in-the-cultured-medium
#4
Teresinha Leal, Gabriella Bergamini, François Huaux, Nadtha Panin, Sabrina Noel, Barbara Dhooghe, Jeremy B Haaf, Pierluigi Mauri, Sara Motta, Dario Di Silvestre, Paola Melotti, Claudio Sorio
BACKGROUND: Pseudomonas aeruginosa airway infections are a major cause of morbidity and mortality in patients with cystic fibrosis (CF). Azithromycin improves the related clinical outcomes, but its mechanisms of action remain poorly understood. We tested the hypothesis that azithromycin downregulates P. aeruginosa-induced pro-inflammatory responses by modifying release of bacterial proteins. METHODS: We monitored inflammatory markers in lungs of CF mutant mice and their littermate controls in response to conditioned media (CM) collected from the reference P...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27887948/s-allyl-cysteine-ameliorates-cognitive-deficits-in-streptozotocin-diabetic-rats-via-suppression-of-oxidative-stress-inflammation-and-acetylcholinesterase
#5
Tourandokht Baluchnejadmojarad, Zahra Kiasalari, Siamak Afshin-Majd, Zahra Ghasemi, Mehrdad Roghani
Diabetes mellitus (DM) is associated with learning, memory, and cognitive deficits. S-allyl cysteine (SAC) is the main organosulfur bioactive molecule in aged garlic extract with anti-diabetic, antioxidant, anti-inflammatory and nootropic property. This research was conducted to evaluate the efficacy of SAC on alleviation of learning and memory deficits in streptozotocin (STZ)-diabetic rats and to explore involvement of toll-like receptor 4 (TLR4), nuclear factor (erythroid-derived 2)-like 2 (Nrf2), nuclear factor-kappa B (NF-κB), and heme oxygenase 1 (HO-1) signaling cascade...
November 22, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27884085/the-roles-of-myeloperoxidase-in-coronary-artery-disease-and-its-potential-implication-in-plaque-rupture
#6
Nathaniel Teng, Ghassan J Maghzal, Jihan Talib, Imran Rashid, Antony K Lau, Roland Stocker
Atherosclerosis is the main pathophysiological process underlying coronary artery disease (CAD). Acute complications of atherosclerosis, such as myocardial infarction, are caused by the rupture of vulnerable atherosclerotic plaques, which are characterized by thin, highly inflamed, and collagen-poor fibrous caps. Several lines of evidence mechanistically link the heme peroxidase myeloperoxidase (MPO), inflammation as well as acute and chronic manifestations of atherosclerosis. MPO and MPO-derived oxidants have been shown to contribute to the formation of foam cells, endothelial dysfunction and apoptosis, the activation of latent matrix metalloproteinases, and the expression of tissue factor that can promote the development of vulnerable plaque...
November 25, 2016: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27878246/luteolin-protects-mice-from-severe-acute-pancreatitis-by-exerting-ho-1-mediated-anti-inflammatory-and-antioxidant-effects
#7
Jie Xiong, Kezhou Wang, Chunxiao Yuan, Rong Xing, Jianbo Ni, Guoyong Hu, Fengling Chen, Xingpeng Wang
Reseda odorata L. has long been used in traditional Asian medicine for the treatment of diseases associated with oxidative injury and acute inflammation, such as endotoxemia, acute lung injury, acute myocardial infarction and hepatitis. Luteolin, the main component of Reseda odorata L., which is also widely found in many natural herbs and vege-tables, has been shown to induce heme oxygenase-1 (HO-1) expression to exert anti-inflammatory and antioxidant effects. In this study, we aimed to examine the effects of luteolin on mice with severe acute pancreatitis (SAP), and to explore the underlying mechanisms...
November 22, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27878238/nobiletin-attenuates-lipopolysaccharide-d%C3%A2-galactosamine%C3%A2-induced-liver-injury-in-mice-by-activating-the-nrf2-antioxidant-pathway-and-subsequently-inhibiting-nf%C3%A2-%C3%AE%C2%BAb%C3%A2-mediated-cytokine-production
#8
Zhenxing He, Xuanfei Li, Hao Chen, Kun He, Yiming Liu, Junhua Gong, Jianping Gong
Inflammation and oxidative stress serve an important role in the development of lipopolysaccharide/D-galactosamine (LPS/GalN)‑induced acute liver injury. Nobiletin, which is found in high quantities in the peel of citrus fruits, is able to modulate immune responses, including inflammatory response and oxidative stress. The present study aimed to evaluate the protective effects of nobiletin on LPS/GalN‑induced acute liver injury. Male C57BL/6 mice were intraperitoneally treated with nobiletin (50, 100 and 200 mg/kg) 2 h prior to LPS/GalN injection...
November 15, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27876112/antioxidant-defense-of-nrf2-vs-pro-inflammatory-system-of-nf-%C3%AE%C2%BAb-during-the-amoebic-liver-infection-in-hamster
#9
Liseth R Aldaba-Muruato, Martin H Muñoz-Ortega, María Del R Campos-Esparza, José R Macías-Pérez, Nayeli A Márquez-Muñoz, Ana G Villalobos-Santos, Javier Ventura-Juárez
Entamoeba histolytica is the causative agent of amoebic liver abscess (ALA), which course with an uncontrolled inflammation and nitro-oxidative stresses, although it is well known that amoeba has an effective defence mechanisms against this toxic environment, the underlying molecular factors responsible for progression of tissue damage remain largely unknown. The purpose of the present study was to determine during the acute stage of ALA in hamsters, the involvement of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) and nuclear factor-kappa B (NF-κB), which are activated in response to oxidative stress...
November 23, 2016: Parasitology
https://www.readbyqxmd.com/read/27873232/evidence-based-revised-view-of-the-pathophysiology-of-preeclampsia
#10
Asif Ahmed, Homira Rezai, Sophie Broadway-Stringer
Preeclampsia is a life-threatening vascular disorder of pregnancy due to a failing stressed placenta. Millions of women risk death to give birth each year and globally each year, almost 300,000 lose their life in this process and over 500,000 babies die as a consequence of preeclampsia. Despite decades of research, we lack pharmacological agents to treat it. Maternal endothelial oxidative stress is a central phenomenon responsible for the preeclampsia phenotype of high maternal blood pressure and proteinuria...
November 22, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27866474/heme-oxygenase-1-transduced-bone-marrow-mesenchymal-stem-cells-in-reducing-acute-rejection-and-improving-small-bowel-transplantation-outcomes-in-rats
#11
Yang Yang, Hong Li Song, Wen Zhang, Ben Juan Wu, Nan Nan Fu, Chong Dong, Zhong Yang Shen
BACKGROUND: We determined whether bone marrow mesenchymal stem cells (BMMSCs) transduced with heme oxygenase-1 (HO-1), a cytoprotective and immune-protective factor, could improve outcomes for small bowel transplantation (SBTx) in rats. METHODS: We performed heterotopic SBTx from Brown Norway rats to Lewis rats, before infusing Ad/HO-1-transduced BMMSCs (Ad/HO-1/BMMSCs) through the superficial dorsal veins of the penis. Respective infusions with Ad/BMMSCs, BMMSCs, and normal saline served as controls...
November 20, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27847555/sulforaphane-protects-pancreatic-acinar-cell-injury-by-modulating-nrf2-mediated-oxidative-stress-and-nlrp3-inflammatory-pathway
#12
Zhaojun Dong, Haixiao Shang, Yong Q Chen, Li-Long Pan, Madhav Bhatia, Jia Sun
Acute pancreatitis (AP) is characterized by early activation of intra-acinar proteases followed by acinar cell death and inflammation. Cellular oxidative stress is a key mechanism underlying these pathological events. Sulforaphane (SFN) is a natural organosulfur antioxidant with undescribed effects on AP. Here we investigated modulatory effects of SFN on cellular oxidation and inflammation in AP. AP was induced by cerulean hyperstimulation in BALB/c mice. Treatment group received a single dose of 5 mg/kg SFN for 3 consecutive days before AP...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27836774/peroxidase-enzymes-inhibit-osteoclast-differentiation-and-bone-resorption
#13
Vasilios Panagopoulos, Vasilios Liapis, Irene Zinonos, Shelley Hay, Damien A Leach, Wendy Ingman, Mark O DeNichilo, Gerald J Atkins, David M Findlay, Andrew C W Zannettino, Andreas Evdokiou
Myeloperoxidase (MPO) and eosinophil peroxidase (EPO) are heme-containing enzymes, well known for their antimicrobial activity, are released in abundance by innate immune infiltrates at sites of inflammation and injury. We have discovered new and previously unrecognised roles for heme peroxidases in extracellular matrix biosynthesis, angiogenesis, and bone mineralisation, all of which play an essential role in skeletal integrity. In this study we used in vitro models of osteoclastogenesis to investigate the effects of heme peroxidase enzymes on osteoclast differentiation and bone resorbing activity, pertinent to skeletal development and remodelling...
November 9, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27832188/melatonin-receptor-agonists-as-the-perioceutics-agents-for-periodontal-disease-through-modulation-of-porphyromonas-gingivalis-virulence-and-inflammatory-response
#14
Wei Zhou, Xuan Zhang, Cai-Lian Zhu, Zhi-Yan He, Jing-Ping Liang, Zhong-Chen Song
AIM: "Perioceutics" including antimicrobial therapy and host modulatory therapy has emerged as a vital adjunctive treatment of periodontal disease. Melatonin level was significantly reduced in patients with periodontal diseases suggesting melatonin could be applied as a potential "perioceutics" treatment of periodontal diseases. This study aims to investigate the effects of melatonin receptor agonists (melatonin and ramelteon) on Porphyromonas gingivalis virulence and Porphyromonas gingivalis-derived lipopolysaccharide (Pg-LPS)-induced inflammation...
2016: PloS One
https://www.readbyqxmd.com/read/27825756/carvacrol-attenuates-acute-kidney-injury-induced-by-cisplatin-through-suppression-of-erk-and-pi3k-akt-activation
#15
Iva Potočnjak, Robert Domitrović
We investigated the mechanisms of renoprotective effects of carvacrol, a monoterpenoid compound, against cisplatin (CP)-induced kidney injury. Male BALB/cN mice were orally administered 1, 3, and 10 mg carvacrol/kg body weight for two days, 48 h after intraperitoneal injection of CP (13 mg/kg). Four days after CP administration, renal oxidative stress was evidenced by increased expression of 4-hydroxynonenal (4-HNE), 3-nitrotyrosine (3-NT), cytochrome P450 E1 (CYP2E1), and heme oxygenase-1 (HO-1). CP treatment increased the expression of phosphorylated nuclear factor-kappaB (p-NF-κB) p65 and tumor necrosis factor-alpha (TNF-α) in kidneys, suggesting inflammatory response...
November 4, 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27823627/anti-neuroinflammatory-effect-of-sophoraflavanone-g-from-sophora-alopecuroides-in-lps-activated-bv2-microglia-by-mapk-jak-stat-and-nrf2-ho-1-signaling-pathways
#16
Chao Guo, Lei Yang, Chuan-Xing Wan, Yuan-Zheng Xia, Chao Zhang, Meng-Han Chen, Zhen-Dong Wang, Zhong-Rui Li, Xue-Mei Li, Ya-Di Geng, Ling-Yi Kong
BACKGROUND: Neuroinflammation plays a vital role in Alzheimer's disease (AD) and other neurodegenerative conditions. Sophora alopecuroides is widely used in traditional Uighur's medicine for the treatment of inflammation. Sophoraflavanone G (SG), a major flavonoid found in the S. alopecuroides, has also been reported to exhibit anti-inflammatory activity both in vitro and in vivo. However, the effect of S. alopecuroides and SG on microglia-mediated neuroinflammation has not been investigated...
December 1, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27810922/-lubac-deficiency-perturbs-tlr3-signaling-to-cause-immunodeficiency-and-autoinflammation
#17
Julia Zinngrebe, Eva Rieser, Lucia Taraborrelli, Nieves Peltzer, Torsten Hartwig, Hongwei Ren, Ildikó Kovács, Cornelia Endres, Peter Draber, Maurice Darding, Silvia von Karstedt, Johannes Lemke, Balazs Dome, Michael Bergmann, Brian J Ferguson, Henning Walczak
The linear ubiquitin chain assembly complex (LUBAC), consisting of SHANK-associated RH-domain-interacting protein (SHARPIN), heme-oxidized IRP2 ubiquitin ligase-1 (HOIL-1), and HOIL-1-interacting protein (HOIP), is a critical regulator of inflammation and immunity. This is highlighted by the fact that patients with perturbed linear ubiquitination caused by mutations in the Hoip or Hoil-1 genes, resulting in knockouts of these proteins, may simultaneously suffer from immunodeficiency and autoinflammation. TLR3 plays a crucial, albeit controversial, role in viral infection and tissue damage...
November 14, 2016: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27799462/sodium-butyrate-activates-nrf2-to-ameliorate-diabetic-nephropathy-possibly-via-inhibition-of-hdac
#18
Wenpeng Dong, Ye Jia, Xiuxia Liu, Huan Zhang, Tie Li, Wenlin Huang, Xudong Chen, Fuchun Wang, Weixia Sun, Hao Wu
Oxidative stress contributes to the pathogenesis of diabetic nephropathy (DN). Nuclear factor erythroid 2-related factor 2 (NRF2) plays a key role in cellular defense against oxidative stress. NRF2 activators have shown promising preventive effects on DN. Sodium butyrate (NaB) is a known activator of NRF2. However, it is unknown whether NRF2 is required for NaB protection against DN. Therefore, streptozotocin-induced diabetic C57BL/6 Nrf2 knockout and their wild-type mice were treated in the presence or absence of NaB for 20 weeks...
January 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/27799046/targeting-the-nrf2-heme-oxygenase-1-axis-after-intracerebral-hemorrhage
#19
Jing Chen-Roetling, Raymond F Regan
BACKGROUND: Injury to cells adjacent to an intracerebral hemorrhage (ICH) is likely mediated at least in part by toxins released from the hematoma that initiate complex and interacting injury cascades. Pharmacotherapies targeting a single toxin or pathway, even if consistently effective in controlled experimental models, have a high likelihood of failure in a variable clinical setting. Nuclear factor erythroid-2 related factor 2 (Nrf2) regulates the expression of heme oxygenase-1 (HO-1) and multiple other proteins with antioxidant and anti-inflammatory effects, and may be a target of interest after ICH...
October 27, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27796617/heme-exposed-pooled-therapeutic-igg-improves-endotoxemia-survival
#20
Iglika Djoumerska-Alexieva, Lubka T Roumenina, Tsvetanka Stefanova, Tchavdar Vassilev, Jordan D Dimitrov
Antibody repertoires of healthy humans and animals contain a fraction of antibodies able to acquire additional polyspecificity following exposure to several biologically relevant redox molecules (free heme, reactive oxygen species, ferrous ions, HOCl, etc.). The physiological role of these "hidden" polyspecific antibodies is poorly understood. Similar to inherently polyspecific antibodies, those with induced polyspecificicty may also have immunoregulatory properties. We have previously shown that a pooled human IgG preparation, modified by the exposure to ferrous ions, acquires the ability to significantly improve survival of animals with polymicrobial sepsis or aseptic systemic inflammation induced by bacterial lipopolysaccharide or zymosan administration...
October 28, 2016: Inflammation
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