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https://www.readbyqxmd.com/read/28924387/activation-of-nrf2-attenuates-pulmonary-vascular-remodeling-via-inhibiting-endothelial-to-mesenchymal-transition-an-insight-from-a-plant-polyphenol
#1
Yucai Chen, Tianyi Yuan, Huifang Zhang, Yu Yan, Danshu Wang, Lianhua Fang, Yang Lu, Guanhua Du
The endothelial-to-mesenchymal transition (EndMT) has been demonstrated to be involved in pulmonary vascular remodeling. It is partly attributed to oxidative and inflammatory stresses in endothelial cells. In current study, we conducted a series of experiments to clarify the effect of salvianolic acid A (SAA), a kind of polyphenol compound, in the process of EndMT in human pulmonary arterial endothelial cells and in vivo therapeutic efficacy on vascular remodeling in monocrotaline (MCT)-induced EndMT. EndMT was induced by TGFβ1 in human pulmonary arterial endothelial cells (HPAECs)...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28923648/octreotide-ameliorates-renal-ischemia-reperfusion-injury-via-antioxidation-and-anti-inflammation
#2
Z Xu, K Zhao, P Han, X Qi, W Zhang, T Niu
Oxidative stress, calcium overload, inflammation, cellular necrosis, and apoptosis are implicated in renal ischemic/reperfusion injury (RIRI). Because octreotide (OCT) is protective in retinal IRI, the effect of OCT on mouse RIRI and the mechanisms involved were investigated. The RIRI model was induced in male C57BL/6 mice, and the mice were then treated with saline or OCT. Serum and kidneys were subjected to periodic acid-Schiff staining, terminal deoxynucleotidyl transferase dUTP nick end labeling assay, enzyme-linked immunosorbent assay, western blotting, and immunohistochemistry...
October 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28912452/endogenous-%C3%AF-3-fatty-acid-production-by-fat-1-transgene-and-topically-applied-docosahexaenoic-acid-protect-against-uvb-induced-mouse-skin-carcinogenesis
#3
Hye-Won Yum, Jin Park, Hyun-Jung Park, Jun Wan Shin, Yong-Yeon Cho, Su-Jung Kim, Jing X Kang, Young-Joon Surh
The present study was intended to explore the effects of endogenously produced ω-3 polyunsaturated fatty acids (PUFAs) on ultraviolet B (UVB)-induced skin inflammation and photocarcinogenesis using hairless fat-1 transgenic mice harboring ω-3 desaturase gene capable of converting ω-6 to ω-3 PUFAs. Upon exposure to UVB irradiation, fat-1 transgenic mice exhibited a significantly reduced epidermal hyperplasia, oxidative skin damage, and photocarcinogenesis as compared to wild type mice. The transcription factor, Nrf2 is a master regulator of anti-inflammatory and antioxidant gene expression...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28912017/indoleamine-2-3-dioxygenase-1-increased-in-human-gastric-pre-neoplasia-promotes-inflammation-and-metaplasia-in-mice-and-is-associated-with-type-ii-hypersensitivity-autoimmunity
#4
Mohamad El-Zaatari, Adam J Bass, Reanne Bowlby, Min Zhang, Li-Jyun Syu, Yitian Yang, Helmut Grasberger, Andrew Shreiner, Bei Tan, Shrinivas Bishu, Wai K Leung, Andrea Todisco, Nobuhiko Kamada, Marilia Cascalho, Andrzej A Dlugosz, John Y Kao
BACKGROUND & AIMS: Chronic gastrointestinal inflammation increases the risk of cancer by mechanisms that are not well understood. Indoleamine-2,3-dioxygenase 1 (IDO1) is a heme-binding enzyme that regulates the immune response via catabolization and regulation of tryptophan availability for immune cell uptake. IDO1 expression is increased during the transition from chronic inflammation to gastric metaplasia. We investigated whether IDO1 contributes to the inflammatory response that mediates loss of parietal cells leading to metaplasia...
September 11, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28910180/nrf2-mediated-ho-1-induction-and-antineuroinflammatory-activities-of-halleridone
#5
Ji Yeon Seo, Euisun Pyo, Junsoo Park, Jong-Sang Kim, Sang Hyun Sung, Won Keun Oh
Nuclear factor E2-related factor 2 (Nrf2) is the master regulator of antioxidant enzymes and is known to act on the nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) signaling pathway. Few studies have examined the bioactivity of halleridone. Herein, we investigated whether halleridone, which was isolated from the stems of the plant Cornus walteri, could regulate Nrf2-mediated heme oxygenase (HO)-1 expression and prevent intramicroglial inflammation induced by amyloid beta (Aβ)1-42 overexpression...
September 14, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28906458/combination-of-hypertension-along-with-a-high-fat-and-cholesterol-diet-induces-severe-hepatic-inflammation-in-rats-via-a-signaling-network-comprising-nf-%C3%AE%C2%BAb-mapk-and-nrf2-pathways
#6
Yuan Yuan, Hisao Naito, Xiaofang Jia, Kazuya Kitamori, Tamie Nakajima
Populations with essential hypertension have a high risk of nonalcoholic steatohepatitis (NASH). In this study, we investigated the mechanism that underlies the progression of hypertension-associated NASH by comparing differences in the development of high fat and cholesterol (HFC) diet-induced NASH among three strains of rats, i.e., two hypertensive strains comprising spontaneously hypertensive rats and the stroke-prone spontaneously hypertensive 5/Dmcr, and the original Wistar Kyoto rats as the normotensive control...
September 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28901400/taurine-alleviates-lipopolysaccharide%C3%A2-induced-liver-injury-by-anti%C3%A2-inflammation-and-antioxidants-in-rats
#7
Yueyan Liu, Feng Li, Li Zhang, Jianfeng Wu, Yanmei Wang, Hong Yu
The aim of the present study was to investigate the protective effect of taurine on lipopolysaccharide (LPS)‑induced liver injury and its mechanisms. Male rats were randomly divided into three groups: Normal saline, LPS model and taurine treatment. Experimental animals were treated with saline or taurine (dissolved in saline, 200 mg/kg/day) via intravenous injection. After 2 h, saline or LPS (0.5 mg/kg) was administrated via intraperitoneal injection. Markers of liver injury, pro‑inflammatory cytokines and superoxide dismutase (SOD) activity were determined in plasma...
August 31, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28898431/anti-inflammatory-and-anti-oxidant-properties-of-schisandrin-c-promote-mitochondrial-biogenesis-in-human-dental-pulp-cells
#8
J S Takanche, Y-H Lee, J-S Kim, J-E Kim, S-H Han, S-W Lee, H-K Yi
AIM: To examine the properties of Schisandrin C as an anti-inflammatory and anti-oxidant compound, and whether its characteristics promote mitochondrial biogenesis in human dental pulp cells (HDPCs). METHODOLOGY: HDPCs were extracted from fresh third molars and cultured for experiments. Reactive oxidative stress (ROS) and nitric oxide (NO) formation were analyzed by a Muse cell analyzer. Western blotting and gelatin zymography were used to identify the presence of anti-oxidants, as well as anti-inflammatory and mitochondrial biogenesis with specific antibody...
September 12, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28881715/activation-of-the-nrf2-are-signaling-pathway-by-probucol-contributes-to-inhibiting-inflammation-and-neuronal-apoptosis-after-spinal-cord-injury
#9
Zipeng Zhou, Chang Liu, Shurui Chen, Haosen Zhao, Kang Zhou, Wei Wang, Yajiang Yuan, Zhuo Li, Yue Guo, Zhaoliang Shen, Xifan Mei
The nuclear erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling pathway plays an essential role in the cellular antioxidant and anti-inflammatory responses. Spinal cord injury (SCI) results in a massive release of inflammatory factors and free radicals, which seriously compromise nerve recovery and axon regeneration. In this study, we examined the efficacy of probucol on anti-inflammatory responses and functional recovery after SCI by activating the Nrf2/ARE signaling pathway. We also investigated the mechanism by which inflammation is inhibited in this process...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28872471/lung-xenotransplantation
#10
Hisashi Sahara, Hironosuke Watanabe, Thomas Pomposelli, Kazuhiko Yamada
PURPOSE OF REVIEW: This review describes the most recent progress in xeno lung transplantation (XLTx) to date. It describes the potential mechanisms of early xeno lung graft loss, as well as the latest therapeutic strategies to overcome them. RECENT FINDINGS: Using ex-vivo perfusion models of porcine lungs with human blood, the use of genetically modified pig lungs along with novel pharmaceutical approaches has recently been studied. Strategies that have demonstrated improved lung survival include the knockout of known xenoantigens (GalTKO and N-glycolylneuraminic acid-KO), genes that regulate complement activation (hCD46 and hCD55), as well as the inflammation/coagulation cascade (human leukocyte antigen-E, human thrombomodulin, human endothelial protein C receptor, hCD47, hCD39, hCD73 and heme oxygenase-1)...
September 1, 2017: Current Opinion in Organ Transplantation
https://www.readbyqxmd.com/read/28866823/neuroprotective-effects-of-baicalein-on-acrolein-induced-neurotoxicity-in-the-nigrostriatal-dopaminergic-system-of-rat-brain
#11
Wei-Zhong Zhao, Hsiang-Tsui Wang, Hui-Ju Huang, Yu-Li Lo, Anya Maan-Yuh Lin
Elevated levels of acrolein, an α,β-unsaturated aldehyde are detected in the brain of patients with Parkinson's disease (PD). In the present study, the neuroprotective effect of baicalein (a phenolic flavonoid in the dried root of Scutellaria baicalensis Georgi) on acrolein-induced neurodegeneration of nigrostriatal dopaminergic system was investigated using local infusion of acrolein in the substantia nigra (SN) of rat brain. Systemic administration of baicalein (30 mg/kg, i.p.) significantly attenuated acrolein-induced elevations in 4-hydroxy-2-noneal (a product of lipid peroxidation), N-(3-formyl-3,4-dehydropiperidino)lysine (a biomarker of acrolein-conjugated proteins), and heme-oxygenase-1 levels (a redox-regulated protein) in the infused SN, indicating that baicalein inhibited acrolein-induced oxidative stress and protein conjugation...
September 2, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28853207/curcumin-ameliorates-severe-influenza-pneumonia-via-attenuating-lung-injury-and-regulating-macrophage-cytokines-production
#12
Shuguang Han, Jing Xu, Xiangjun Guo, Mao Huang
Curcumin, an active phenolic agent extract from the Curcuma longa, exhibits excellent anti-cancer, anti-inflammation, and neuroprotective effects. We aimed to investigate the anti-influenza role of Curcumin in vitro and in vivo. The effect of Curcumin on replication of influenza A virus (IAV) was examined in human lung cancer cell line A549, as well as in a mouse model. Curcumin could inhibit IAV in vitro and alleviate the severity of the disease in the mouse after infection with IAV. The results also indicated that Curcumin could trigger expression of Heme oxygenase-1 in vivo and attenuate IAV-induced injury to the lung tissue...
August 29, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28842295/macrophage-heme-oxygenase-1-sirt1-p53-axis-regulates-sterile-inflammation-in-liver-ischemia-reperfusion-injury
#13
Kojiro Nakamura, Min Zhang, Shoichi Kageyama, Bibo Ke, Takehiro Fujii, Rebecca A Sosa, Elaine F Reed, Nakul Datta, Ali Zarrinpar, Ronald W Busuttil, Jesus A Araujo, Jerzy W Kupiec-Weglinski
BACKGROUND &AIMS: Hepatic ischemia-reperfusion injury (IRI), an exogenous antigen-independent local inflammation and hepatocellular death, represents a risk factor for acute and chronic rejection in liver transplantation. METHODS: To gain insights into molecular communication in the mechanism of liver IRI, we analyzed human liver transplants in parallel with primary murine macrophage cell cultures and IR-stressed livers in myeloid-specific HO-1 (heme oxygenase-1) gene mutant mice for anti-inflammatory and cytoprotective functions of macrophage-specific HO-1 / SIRT1 (sirtuin 1) / p53 (tumor suppressor protein) signaling RESULTS: Decreased HO-1 expression in human post-reperfusion liver transplant biopsies correlated with deteriorated hepatocellular function (serum ALT; p<0...
August 23, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28836936/protective-effects-of-heme-oxygenase-1-against-severe-acute-pancreatitis-via-inhibition-of-tumor-necrosis-factor-%C3%AE-and-augmentation-of-interleukin-10
#14
Fei-Hu Zhang, Yu-Han Sun, Kai-Liang Fan, Xiao-Bin Dong, Ning Han, Hao Zhao, Li Kong
BACKGROUND: Heme oxygenase-1 (HO-1) is an inducible defense gene which plays a significant role in inflammation. HO-1 protects cells and tissues through the mechanism of anti-oxidation, maintaining microcirculation and anti-inflammation. The aim of the current study is to investigate the role of HO-1 on systemic inflammatory response in severe acute pancreatitis (SAP). METHODS: Forty male Sprague-Dawley (SD) rats were randomly assigned into four groups: control group (n = 10); SAP group (n = 10), SAP model was induced by retrograde injection of 3% sodium taurocholate through pancreatic duct; HO-1 stimulation group (n = 10), SD rats were injected 75 μg/kg hemin intraperitoneally 30 min after induction of SAP; HO-1 inhibition group (n = 10), SD rats were injected 20 μg/kg Zinc porphyrin (Zn-PP) intraperitoneally 30 min after induction of SAP...
August 24, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28822969/preconditioning-with-the-bkca-channel-activator-ns-1619-prevents-ischemia-reperfusion-induced-inflammation-and-mucosal-barrier-dysfunction-ros-and-ho-1
#15
Hongyan Dai, Meifang Wang, Parag N Patel, Theodore J Kalogeris, Yajun Liu, William Durante, Ronald J Korthuis
Activation of large conductance, calcium-activated potassium (BKCa) channels evokes cell survival programs that mitigate intestinal ischemia and reperfusion (I/R) inflammation and injury 24 hours later. The goal of the current study was to determine the role of reactive oxygen species (ROS) and heme oxygenase (HO)-1 in delayed acquisition of tolerance to I/R induced by pretreatment with the BKCa channel opener NS-1619. Superior mesentery arteries were occluded for 45 min followed by reperfusion for 70 min in wild type (WT) or HO-1 null (HO-1(-/-)) mice that were pretreated with NS-1619 or saline vehicle 24 hrs earlier...
August 19, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28811386/trimetazidine-protects-retinal-ganglion-cells-from-acute-glaucoma-via-the-nrf2-ho-1-pathway
#16
Peixing Wan, Wenru Su, Yingying Zhang, Zhidong Li, Caibin Deng, Yehong Zhuo
Acute glaucoma is one of the leading causes of irreversible vision impairment characterized by the rapid elevation of intraocular pressure (IOP) and consequent retinal ganglion cell (RGC) death. Oxidative stress and neuroinflammation have been considered critical for the pathogenesis of RGC death in acute glaucoma. Trimetazidine (TMZ), an anti-ischemic drug, possesses antioxidative and anti-inflammatory properties, contributing to its therapeutic potential in tissue damage. However, the role of TMZ in acute glaucoma and the underlying molecular mechanisms remain elusive...
September 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28807985/inhaled-carbon-monoxide-from-toxin-to-therapy
#17
Dean R Hess
Carbon monoxide (CO) is usually recognized as a toxic gas that can be used to assess lung function in the pulmonary function laboratory. The toxicity of CO relates to its high affinity for hemoglobin and other heme molecules, producing carboxyhemoglobin (HbCO). Despite that blood HbCO levels are commonly measured in patients with CO poisoning, the clinical presentation often does not correlate with the HbCO level, and clinical improvement in the patient's condition does not correlate with HbCO clearance. In patients with CO poisoning, administration of 100% O2 is standard practice...
August 14, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28805232/the-protective-effect-of-heme-oxygenase-1-against-intestinal-barrier-dysfunction-in-cholestatic-liver-injury-is-associated-with-nf-%C3%AE%C2%BAb-inhibition
#18
Lijing Zhang, Zhenling Zhang, Bojia Liu, Yanling Jin, Yan Tian, Yi Xin, Zhijun Duan
Heme oxygenase-1 (HO-1) is reported to protect against liver injury, but little is known about its effect on the intestinal barrier in cholestatic liver injury. In this study, we investigated the effects of HO-1 and its enzymatic by-product on intestinal barrier dysfunction in bile duct ligation (BDL) rats and explored the possible mechanism. The HO-1 inducer cobalt protoporphyrin (CoPP) and carbon monoxide-releasing molecule-2 (CORM-2) were used; the expression levels of tight junction (TJ) proteins, intestinal inflammation and NF-κB p65 were measured...
August 9, 2017: Molecular Medicine
https://www.readbyqxmd.com/read/28801265/fluoxetine-coupled-with-zinc-in-a-chronic-mild-stress-model-of-depression-providing-a-reservoir-for-optimum-zinc-signaling-and-neuronal-remodeling
#19
Nesreen Nabil Omar, Reham Fathy Tash
BACKGROUND: Recently, depression has been envisioned as more than an alteration in neurotransmitters centered around receptor signaling pathways. Consequently, the precise mechanisms of selective serotonin reuptake inhibitor (SSRI) antidepressant drugs such as fluoxetine are being revisited. Zinc is a trace element that has been long implicated in the psychopathology and therapy of depression. Zinc has been found to be sequestered and dispensed during stress and inflammation through a family of proteins called metallothioneins (MTs)...
August 9, 2017: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28796886/macrophage-metabolism-in-atherosclerosis
#20
REVIEW
Gael F P Bories, Norbert Leitinger
A key aspect of atherosclerosis is the maladaptive inflammatory response to lipoprotein accumulation in the artery. The failure to decrease lipid accumulation, to clear apoptotic cells and to resolve inflammation ultimately leads to macrophage accumulation within the vascular wall(1,2,3,4) . Several subsets of macrophages are found inside atherosclerotic plaques(5,6,7) : Pro-inflammatory M1-like macrophages potentially participate in atherosclerosis initiation and progression; M2-like macrophages are thought to be protective due to their anti-inflammatory and profibrotic properties, presumably stabilizing the plaque(8,9;) Mox macrophages develop in response to oxidized phospholipids and present a glutathione- and potentially redox-regulating phenotype(10) ; Mhem macrophages are found in areas of plaque hemorrhage(11,12) where they are involved in heme clearance...
August 10, 2017: FEBS Letters
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