Tomasz W Kaminski, Ayynar Sivanantham, Anna Mozhenkova, Ashley Smith, Ramakrishna Ungalara, Rikesh Dubey, Bibhav Shrestha, Corinne Hanway, Omika Katoch, Jesús Tejero, Prithu Sundd, Enrico M Novelli, Gregory J Kato, Tirthadipa Pradhan-Sundd
Sickle cell disease (SCD) associated chronic hemolysis promotes oxidative stress, inflammation and thrombosis leading to organ damage, including liver damage. Hemoglobin scavenger receptor CD163 plays a protective role in SCD by scavenging both hemoglobin-haptoglobin complexes and cell free hemoglobin. A limited number of studies in the past have shown a positive correlation of CD163 expression with poor disease outcomes in patients with SCD. However, the role and regulation of CD163 in SCD related hepatobiliary injury has not been fully elucidated yet...
April 29, 2024: American Journal of Physiology. Cell Physiology