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https://www.readbyqxmd.com/read/29176143/effect-of-cognitive-behavioral-therapy-versus-interpersonal-psychotherapy-in-patients-with-major-depressive-disorder-a-meta-analysis-of-randomized-controlled-trials
#1
She-Gang Zhou, Yan-Fei Hou, Ding Liu, Xiao-Yuan Zhang
BACKGROUND: Practice guidelines have recommended cognitive behavioral therapy (CBT) and interpersonal psychotherapy (IPT) as the treatment of choice for major depression disorder (MDD). However, whether one therapy is better than the other remains inconclusive. The aim of this study was to compare the treatment efficacy of the two treatment approaches for MDD. METHODS: Using the terms "cognitive behavior therapy or cognitive therapy or CBT or CT or cognitive behavioral therapy" and "interpersonal psychotherapy or IPT," we systematically searched PubMed, Psyclnfo and Chinese National Knowledge Infrastructure databases up to February 2017...
December 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29149756/residual-anxiety-may-be-associated-with-depressive-relapse-during-continuation-therapy-of-bipolar-ii-depression
#2
Lorenzo Lorenzo-Luaces, Jay D Amsterdam, Robert J DeRubeis
BACKGROUND: Anxiety symptoms are common in bipolar disorder. We explored the effect of anxiety on the outcome of acute and continuation pharmacotherapy of bipolar II depression. METHODS: Data were derived from a randomized double-blind 12-week acute (N = 129) and 6-month continuation (N = 55) comparison of venlafaxine versus lithium monotherapy in bipolar II depression in adults. We distinguished between the items of the Hamilton Rating Scale for Depression (HRSD) that capture depression vs...
November 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28910748/local-functional-connectivity-density-is-closely-associated-with-the-response-of-electroconvulsive-therapy-in-major-depressive-disorder
#3
Jiaojian Wang, Qiang Wei, Xinru Yuan, Xiaoyan Jiang, Jinping Xu, Xiaoqin Zhou, Yanghua Tian, Kai Wang
BACKGROUND: Electroconvulsive therapy (ECT) has been demonstrated to be an effective treatment of major depressive disorder (MDD). However, the neuroanatomical basis of response to ECT is still largely unknown. METHODS: In present study, we used functional connectivity density (FCD) and resting-state functional connectivity (RSFC) to identify the relationship between the changes of resting-state activities and ECT responses in 23 MDD patients before and after ECT...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28472556/factors-associated-with-greater-severity-of-depression-in-chilean-primary-care-patients
#4
Verónica Vitriol, Alfredo Cancino, Soledad Ballesteros, Soledad Potthoff, Carlos Serrano
Objective: To determine clinical and psychosocial variables associated with increased depression severity in patients who consult public primary health care clinics (PHCs) in Chile. Methods: The study included 394 patients diagnosed with major depressive disorder (MDD) according to ICD-10 criteria who were evaluated between February and September 2014 using a sociodemographic interview, the Mini-International Neuropsychiatric Interview (MINI), a screening for childhood trauma, a scale for partner violence, the Life Events Survey (LES), and the Hamilton Rating Scale for Depression (HRSD)...
May 4, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/28460314/abnormal-functional-connectivity-within-resting-state-networks-is-related-to-rtms-based-therapy-effects-of-treatment-resistant-depression-a-pilot-study
#5
Ruiyang Ge, Daniel M Blumberger, Jonathan Downar, Zafiris J Daskalakis, Adam A Dipinto, Joseph C W Tham, Raymond Lam, Fidel Vila-Rodriguez
BACKGROUND: Treatment resistant depression (TRD) remains a clinical challenge, and finding biomarkers that predict treatment response are a long sought goal to precisely indicate treatments. This pilot study aims to characterize brain dysfunction in TRD patients who underwent rTMS to define neuroimaging biomarkers that discriminate non-responders (NR) from responders (R). METHODS: 20 TRD patients who underwent a course of rTMS to the left DLPFC were categorized into R and NR groups based on a >50% reduction in HRSD scores...
April 26, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28459660/beta-adrenoceptor-polymorphism-and-clinical-response-to-sertraline-in-major-depressive-patients
#6
Negar Firouzabadi, Roshanak Raeesi, Kamiar Zomorrodian, Ehsan Bahramali, Ilnaz Yavarian
PURPOSE: The adrenoceptor family, as one of the main contributors in regulating the noradrenergic system, has been studied in involvement of depression and its treatment. A functional polymorphism of G1165C on beta adrenoceptor (βAR) enhances post receptor signalling and is assumed to be involved in pharmacotherapy of depression. The aim of the present study was to discern the influence of G1165C polymorphism in the β1AR gene on individual differences in response to sertraline. METHODS: One hundred newly diagnosed patients completed 6 weeks of sertraline treatment...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28293046/efficacy-of-risperidone-augmentation-with-ondansetron-in-the-treatment-of-negative-and-depressive-symptoms-in-schizophrenia-a-randomized-clinical-trial
#7
Roya Samadi, Susan Soluti, Reza Daneshmand, Shervin Assari, Ali Akhoundpour Manteghi
BACKGROUND: Given the potential role of the 5-hydroxytryptamine-3 receptor in the pathogenesis of schizophrenia, this study was performed to determine whether ondansetron plus risperidone could reduce the negative and depressive symptoms in patients with treatment-resistant schizophrenia. METHODS: In a double-blinded, placebo-controlled, randomized trial (IRCT registration # 201112125280N7), in 2012-2013 in Mashhad, Iran, 38 patients with treatment-resistant schizophrenia received risperidone either combined with a fixed dose (4-8 mg/d) of ondansetron (n=18) or with a placebo (n=20) for 12 weeks...
January 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28278485/dynamic-multimodal-measurement-of-depression-severity-using-deep-autoencoding
#8
Hamdi Dibeklioglu, Zakia Hammal, Jeffrey F Cohn
Depression is one of the most common psychiatric disorders worldwide, with over 350 million people affected. Current methods to screen for and assess depression depend almost entirely on clinical interviews and self-report scales. While useful, such measures lack objective, systematic, and efficient ways of incorporating behavioral observations that are strong indicators of depression presence and severity. Using dynamics of facial and head movement and vocalization, we trained classifiers to detect three levels of depression severity...
March 2, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28230413/the-effects-of-cognitive-behavioral-therapy-are-not-systematically-falling-a-revision-of-johnsen-and-friborg-2015
#9
COMMENT
Ioana A Cristea, Simona Stefan, Eirini Karyotaki, Daniel David, Steven D Hollon, Pim Cuijpers
In a meta-analysis, Johnsen and Friborg (2015) reported a significant negative relationship between publication year and the effect sizes (ESs) of cognitive-behavioral therapy (CBT) for depressive disorders, suggesting its effectiveness was falling. We identified a series of methodological and conceptual caveats and consequently redid the meta-analysis. We used the same inclusion criteria, but only included randomized controlled trials and searched for additional eligible trials. We computed both within-group and between-group ESs for the CBT arm for the Beck Depression Inventory (BDI) and the Hamilton Rating Scale for Depression (HRSD)...
March 2017: Psychological Bulletin
https://www.readbyqxmd.com/read/28225509/psychometric-properties-of-the-reconstructed-hamilton-depression-and-anxiety-scales
#10
Eliora Porter, Dianne L Chambless, Kevin S McCarthy, Robert J DeRubeis, Brian A Sharpless, Marna S Barrett, Barbara Milrod, Steven D Hollon, Jacques P Barber
Although widely used, the Hamilton Rating Scale for Depression (HRSD) and Hamilton Anxiety Rating Scale (HARS) discriminate poorly between depression and anxiety. To address this problem, Riskind, Beck, Brown, and Steer (J Nerv Ment Dis. 175:474-479, 1987) created the Reconstructed Hamilton Scales by reconfiguring HRSD and HARS items into modified scales. To further analyze the reconstructed scales, we examined their factor structure and criterion-related validity in a sample of patients with major depressive disorder and no comorbid anxiety disorders (n = 215) or with panic disorder and no comorbid mood disorders (n = 149)...
August 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28146251/effect-of-disorder-specific-vs-nonspecific-psychotherapy-for-chronic-depression-a-randomized-clinical-trial
#11
RANDOMIZED CONTROLLED TRIAL
Elisabeth Schramm, Levente Kriston, Ingo Zobel, Josef Bailer, Katrin Wambach, Matthias Backenstrass, Jan Philipp Klein, Dieter Schoepf, Knut Schnell, Antje Gumz, Paul Bausch, Thomas Fangmeier, Ramona Meister, Mathias Berger, Martin Hautzinger, Martin Härter
Importance: Chronic depression is a highly prevalent and disabling disorder. There is a recognized need to assess the value of long-term disorder-specific psychotherapy. Objective: To evaluate the efficacy of the Cognitive Behavioral Analysis System of Psychotherapy (CBASP) compared with that of nonspecific supportive psychotherapy (SP). Design, Setting, and Participants: A prospective, multicenter, evaluator-blinded, randomized clinical trial was conducted among adult outpatients with early-onset chronic depression who were not taking antidepressant medication...
March 1, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28144920/the-impact-of-a-single-nucleotide-polymorphism-in-sigmar1-on-depressive-symptoms-in-major-depressive-disorder-and-bipolar-disorder
#12
Laura Mandelli, Sheng-Min Wang, Changsu Han, Soo-Jung Lee, Ashwin A Patkar, Prakash S Masand, Chi-Un Pae, Alessandro Serretti
INTRODUCTION: Ample evidence suggested a role of sigma-1 receptor in affective disorders since the interaction of numerous antidepressants with sigma receptors was discovered. A recent study on Japanese subjects found a genetic variant within the encoding gene SIGMAR1 (rs1800866A>C) associated with major depressive disorder (MDD). We aimed to evaluate the same polymorphism in both MDD and bipolar disorder (BD) as well as its relationship to response to treatment with antidepressants and mood stabilizers...
January 31, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28125252/change-in-self-reported-personality-during-major-depressive-disorder-treatment-a-reanalysis-of-treatment-studies-from-a-demoralization-perspective
#13
Arjen Noordhof, Jan H Kamphuis, Martin Sellbom, Annemarie Eigenhuis, R Michael Bagby
Change in self-reported personality trait scores (especially Neuroticism and Extraversion) over the course of treatment for major depressive disorder (MDD) has been robustly demonstrated. We believe that these observed changes on personality trait scales may reflect reduction in demoralization rather than changes in personality per se. Data were combined from 3 archival samples: a randomized clinical trial and 2 naturalistic follow-up studies. All participants (N = 300) received either psychotherapy or psychopharmacological treatment...
January 26, 2017: Personality Disorders
https://www.readbyqxmd.com/read/28009467/internet-based-cognitive-behavior-therapy-for-major-depressive-disorder-a-randomized-controlled-trial
#14
Isabelle M Rosso, William D S Killgore, Elizabeth A Olson, Christian A Webb, Rena Fukunaga, Randy P Auerbach, Hannah Gogel, Jennifer L Buchholz, Scott L Rauch
BACKGROUND: Prior research has shown that the Sadness Program, a technician-assisted Internet-based cognitive behavioral therapy (iCBT) intervention developed in Australia, is effective for treating major depressive disorder (MDD). The current study aimed to expand this work by adapting the protocol for an American population and testing the Sadness Program with an attention control group. METHODS: In this parallel-group, randomized controlled trial, adult MDD participants (18-45 years) were randomized to a 10-week period of iCBT (n = 37) or monitored attention control (MAC; n = 40)...
March 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/27965856/ketamine-for-depression-relapse-prevention-following-electroconvulsive-therapy-protocol-for-a-randomised-pilot-trial-the-keep-well-trial
#15
Martha Finnegan, Karen Ryan, Enda Shanahan, Andrew Harkin, Leslie Daly, Declan M McLoughlin
BACKGROUND: Major depressive disorder is a common debilitating illness that is the second leading contributor to the global burden of disease. Unfortunately, about 30 % of patients do not respond to adequate trials of antidepressants and/or psychotherapies. About 45-60 % of such treatment-resistant patients will remit with electroconvulsive therapy (ECT). However, relapse rates are high following ECT-38 % after 6 months. There is a need for better relapse prevention strategies. One possibility is to use ketamine, a competitive glutamate receptor antagonist used for anaesthesia...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27833815/performance-usability-and-comparison-of-two-versions-of-a-new-macular-vision-test-the-handheld-radial-shape-discrimination-test
#16
Jae Y Ku, Ashli F Milling, Noelia Pitrelli Vazquez, Paul C Knox
BACKGROUND: Central vision, critical for everyday tasks such as reading and driving, is impacted by age-related changes in the eye and by diseases such as age-related macular degeneration. The detection of changes in macular function is therefore important. The Radial Shape Discrimination (RSD) test measures the threshold at which distortions in a radial frequency pattern can be detected and there is evidence that it is more sensitive to macular pathology than visual acuity (VA). It also provides a more quantitative measure of macular function than the commonly available Amsler grid...
2016: PeerJ
https://www.readbyqxmd.com/read/27810717/the-effectiveness-of-group-based-behavioral-activation-in-the-treatment-of-depression-an-updated-meta-analysis-of-randomized-controlled-trial
#17
Aaroy T Y Chan, Grace Y Y Sun, Wilson W S Tam, Kelvin K F Tsoi, Samuel Y S Wong
BACKGROUND: Depression is a common mental health problem associated with significant morbidity and mortality. Amongst various psychological treatments for depression, individual behavioral activation (BA) has been shown to be effective and relatively simple in its delivery by health care providers although its effectiveness as a group based intervention requires further evidence. The objective of this study is to evaluate and update on the effectiveness of group-based BA to relieve symptoms of depression...
January 15, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27784414/are-patients-with-childhood-onset-of-insomnia-and-depression-more-difficult-to-treat-than-are-those-with-adult-onsets-of-these-disorders-a-report-from-the-triad-study
#18
Jack D Edinger, Rachel Manber, Daniel J Buysse, Andrew D Krystal, Michael E Thase, Phillip Gehrman, Christopher P Fairholme, James Luther, Stephen Wisniewski
STUDY OBJECTIVES: To determine if patients with childhood onsets (CO) of both major depression and insomnia disorder show blunted depression and insomnia treatment responses to concurrent interventions for both disorders compared to those with adult onsets (AO) of both conditions. METHODS: This study was a secondary analysis of data obtained from a multisite randomized clinical trial designed to test the efficacy of combining a psychological/behavior insomnia therapy with antidepressant medication to enhance depression treatment outcomes in patients with comorbid major depression and insomnia...
February 15, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27751859/abnormal-dynamics-of-cortical-resting-state-functional-connectivity-in-chronic-headache-patients
#19
Zewei Wang, Qing Yang, Li Min Chen
The goals of this study are to characterize the temporal dynamics of inter-regional connectivity of the brain in chronic headache (CH) patients versus their age/gender matched controls (CONCH, n=28 pairs), and to determine whether dynamic measures reveal additional features to static functional connectivity and correlate with psychometric scores. Cortical thickness and inter-regional resting state fMRI connectivity were quantified and compared between CH and CONCH groups. Six cortical regions of interest (ROI) pairs that exhibited correlated cortical thickness and static functional connectivity abnormalities were selected for temporal dynamic analysis...
February 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27551669/accuracy-of-automated-classification-of-major-depressive-disorder-as-a-function-of-symptom-severity
#20
Rajamannar Ramasubbu, Matthew R G Brown, Filmeno Cortese, Ismael Gaxiola, Bradley Goodyear, Andrew J Greenshaw, Serdar M Dursun, Russell Greiner
BACKGROUND: Growing evidence documents the potential of machine learning for developing brain based diagnostic methods for major depressive disorder (MDD). As symptom severity may influence brain activity, we investigated whether the severity of MDD affected the accuracies of machine learned MDD-vs-Control diagnostic classifiers. METHODS: Forty-five medication-free patients with DSM-IV defined MDD and 19 healthy controls participated in the study. Based on depression severity as determined by the Hamilton Rating Scale for Depression (HRSD), MDD patients were sorted into three groups: mild to moderate depression (HRSD 14-19), severe depression (HRSD 20-23), and very severe depression (HRSD ≥ 24)...
2016: NeuroImage: Clinical
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