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Zewei Wang, Qing Yang, Li Min Chen
The goals of this study are to characterize the temporal dynamics of inter-regional connectivity of the brain in chronic headache (CH) patients versus their age/gender matched controls (CONCH, n=28 pairs), and to determine whether dynamic measures reveal additional features to static functional connectivity and correlate with psychometric scores. Cortical thickness and inter-regional resting state fMRI connectivity were quantified and compared between CH and CONCH groups. Six cortical regions of interest (ROI) pairs that exhibited correlated cortical thickness and static functional connectivity abnormalities were selected for temporal dynamic analysis...
October 14, 2016: Magnetic Resonance Imaging
Rajamannar Ramasubbu, Matthew R G Brown, Filmeno Cortese, Ismael Gaxiola, Bradley Goodyear, Andrew J Greenshaw, Serdar M Dursun, Russell Greiner
BACKGROUND: Growing evidence documents the potential of machine learning for developing brain based diagnostic methods for major depressive disorder (MDD). As symptom severity may influence brain activity, we investigated whether the severity of MDD affected the accuracies of machine learned MDD-vs-Control diagnostic classifiers. METHODS: Forty-five medication-free patients with DSM-IV defined MDD and 19 healthy controls participated in the study. Based on depression severity as determined by the Hamilton Rating Scale for Depression (HRSD), MDD patients were sorted into three groups: mild to moderate depression (HRSD 14-19), severe depression (HRSD 20-23), and very severe depression (HRSD ≥ 24)...
2016: NeuroImage: Clinical
Merih Altintas, Leman Inanc, Gamze Akcay Oruc, Selim Arpacioglu, Huseyin Gulec
BACKGROUND: This study aimed to evaluate synthetic cannabinoid (SC)-induced psychosis in terms of patient profile and clinical characteristics with reference to concurrently hospitalized schizophrenic patients. METHODS: A total of 81 male patients diagnosed with psychotic disorder induced by the use of SCs (n=50; mean (standard deviation [SD]) age: 25.9 (5.5) years) or with schizophrenia (n=31, mean (SD) age: 42.9 (11.6) years) based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, diagnosis criteria who were concurrently hospitalized at Erenköy Mental and Neurological Diseases Training and Research Hospital were included in this cross-sectional study...
2016: Neuropsychiatric Disease and Treatment
Mariusz S Wiglusz, Jerzy Landowski, Lidia Michalak, Wiesław J Cubała
OBJECTIVE: Depressive disorders are the most common comorbidities among patients with epilepsy (PWE). The availability of standardized clinical instruments for PWE is limited with scarce validation studies available so far. The aim of the study was to validate the Polish Version of the Hamilton Rating Scale for Depression (HRSD) in adult PWE. METHODS: A group of 96 outpatient PWE were examined by a trained psychiatrist using the Structured Clinical Interview (SCID-I) for DSM-IV-TR and the 17-item Polish Version of HRSD (HRSD-17)...
September 2016: Epilepsy & Behavior: E&B
Jaike Praagman, Ester A L de Jonge, Jessica C Kiefte-de Jong, Joline W J Beulens, Ivonne Sluijs, Josje D Schoufour, Albert Hofman, Yvonne T van der Schouw, Oscar H Franco
OBJECTIVE: We assessed whether the association between dietary saturated fatty acids (SFA) and incident coronary heart disease (CHD) depends on the food source, the carbon chain length of SFA, and the substituting macronutrient. APPROACH AND RESULTS: From the Rotterdam Study, 4722 men and women (≥55 years) were included. Baseline (1990-1993) SFA intake was assessed using a validated food frequency questionnaire. CHD (nonfatal myocardial infarction and fatal CHD) was ascertained by medical records...
September 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
Ren-zhi Chen, Min Zhu, Wang Ting, Yu-lin Ji
OBJECTIVE: To explore the comorbidity mechanism of asthma and depression. METHODS: A self-developed questionnaire, which also contained Asthma Control Test (ACT), Asthma Quality of Life Questionnaire (AQLQ) and Hamilton Rating Scale for depression ( HRSD), was administered in 41 participants with asthma (AS), asthma and depression (AD), or none any of these conditions (health control, HC). Lung function and blood levels of eosnophils and IgE were also detected in those in the AS and AD groups...
March 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
Aleksandra Bala, Marta Szantroch, Alicja Gleinert, Andrzej Rysz, Andrzej Marchel
PURPOSE: The aim of the study was to assess the differences in health-related quality of life in groups of men and women suffering with drug-resistant epilepsy and to determine which factors influence quality of life. METHODS: The examined group consisted of 64 subjects with drug-resistant epilepsy - 31 men and 33 women. The mean duration of epilepsy was 17.56±8.92 and 19±9.56years, respectively. The following diagnostic tools were used: QOLIE-31-P, Wechsler Adult Intelligence Scale - Revised (WAIS-R (PL)), and Hamilton Rating Scale for Depression (HRSD)...
July 2016: Epilepsy & Behavior: E&B
Qingzhi Zeng, Wei Chun Wang, Yiru Fang, David Mellor, Marita Mccabe, Linda Byrne, Sai Zuo, Yifeng Xu
Relying on the absence, presence of level of symptomatology may not provide an adequate indication of the effects of treatment for depression, nor sufficient information for the development of treatment plans that meet patients' needs. Using a prospective, multi-centered, and observational design, the present study surveyed a large sample of outpatients with depression in China (n=9855). The 17-item Hamilton Rating Scale for Depression (HRSD-17) and the Remission Evaluation and Mood Inventory Tool (REMIT) were administered at baseline, two weeks later and 4 weeks, to assess patients' self-reported symptoms and general sense of mental health and wellbeing...
July 30, 2016: Psychiatry Research
Rahel Pearson, Rohan H C Palmer, Leslie A Brick, John E McGeary, Valerie S Knopik, Christopher G Beevers
Major depressive disorder (MDD) is a phenotypically heterogeneous disorder with a complex genetic architecture. In this study, genomic-relatedness-matrix restricted maximum-likelihood analysis (GREML) was used to investigate the extent to which variance in depression symptoms/symptom dimensions can be explained by variation in common single nucleotide polymorphisms (SNPs) in a sample of individuals with MDD (N = 1,558) who participated in the National Institute of Mental Health Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study...
May 2016: Journal of Abnormal Psychology
(no author information available yet)
BACKGROUND: To date, several randomized controlled trials (RCTs) have shown the efficacy of repetitive transcranial magnetic stimulation (rTMS) in the treatment of major depression. OBJECTIVE: This analysis examined the antidepressant efficacy of rTMS in patients with treatment-resistant unipolar depression. METHODS: A literature search was performed for RCTs published from January 1, 1994, to November 20, 2014. The search was updated on March 1, 2015...
2016: Ontario Health Technology Assessment Series
Enrico Cocchi, Chiara Fabbri, Changsu Han, Soo-Jung Lee, Ashwin A Patkar, Prakash S Masand, Chi-Un Pae, Alessandro Serretti
BACKGROUND: Genome-wide association studies (GWAS) represent the current frontier in pharmacogenomics. Thousands of subjects of Caucasian ancestry have been included in previous GWAS investigating antidepressant response. GWAS focused on this phenotype are lacking in Asian populations. METHODS: A sample of 109 major depressive disorder (MDD) patients of Korean origin in antidepressant treatment was collected. Phenotypes were response and remission according to the Hamilton Rating Scale for Depression (HRSD)...
2016: BMC Psychiatry
(no author information available yet)
Reports an error in "The effects of cognitive behavioral therapy as an anti-depressive treatment is falling: A meta-analysis" by Tom J. Johnsen and Oddgeir Friborg (Psychological Bulletin, 2015[Jul], Vol 141[4], 747-768). There are several numerical errors in the flowchart summarizing the selection and exclusion of studies as contained in Figure 1. The correct number of titles not further investigated should be 27,381; abstracts rejected should be 1,181; Excluded, different treatment form should be (94). The errors do not affect the results or conclusions of the study as the final number of meta-analysable studies are the same as originally reported...
March 2016: Psychological Bulletin
Giulia Paroni, Davide Seripa, Andrea Fontana, Grazia D'Onofrio, Carolina Gravina, Maria Urbano, Filomena Addante, Madia Lozupone, Massimiliano Copetti, Alberto Pilotto, Antonio Greco, Francesco Panza
Klotho protein, encoded by the Klotho gene (KL) at locus 13q12, is an antiaging hormone-like protein playing a pivotal role in cell metabolism homeostasis and associated to longevity and age-related diseases. In particular, altered cell metabolism in central nervous system may influence the behavior of serotoninergic neurons. The role of KL in the response to treatment with selective serotonin reuptake inhibitors (SSRIs) in late-life depressive syndromes and late-life major depressive disorder (MDD) is unclear...
February 3, 2016: Molecular Neurobiology
Zhen Mu, Yi Chang, Jing Xu, Xiaomei Pang, Huimin Zhang, Xiaowei Liu, Ya Zheng, Xuemei Liu, Xiaojing Liu, Yuan Wan
BACKGROUND: Deficits of pre-attentive information processing have been frequently found in patients with major depressive disorder, nevertheless the results are quite inconsistent due to clinical heterogeneity and methodological difference. Cognitive processing of music is a useful tool for investigating human cognition and its underlying brain mechanisms. Although general auditory processing and perception of musical sound are hampered in patients with MDD, whether the deficits in musical processing begin from pre-attentive stage is not well investigated yet...
April 2016: Journal of Affective Disorders
Jaike Praagman, Joline Wj Beulens, Marjan Alssema, Peter L Zock, Anne J Wanders, Ivonne Sluijs, Yvonne T van der Schouw
BACKGROUND: The association between saturated fatty acid (SFA) intake and ischemic heart disease (IHD) risk is debated. OBJECTIVE: We sought to investigate whether dietary SFAs were associated with IHD risk and whether associations depended on 1) the substituting macronutrient, 2) the carbon chain length of SFAs, and 3) the SFA food source. DESIGN: Baseline (1993-1997) SFA intake was measured with a food-frequency questionnaire among 35,597 participants from the European Prospective Investigation into Cancer and Nutrition-Netherlands cohort...
February 2016: American Journal of Clinical Nutrition
A Roniger, C Späth, U Schweiger, J P Klein
BACKGROUND: The self-rated, 16-item Quick Inventory of Depressive Symptomatology (QIDS-SR16) is a well-established measure of depression severity. This study aimed to evaluate the psychometric properties of the German translation of the QIDS-SR16. METHODS: 332 depressed German adults awaiting psychotherapy were assessed with the German translations of the QIDS-SR16, the Beck Depression Inventory (BDI-II) and the 24-item Hamilton Rating Scale for Depression (HRSD-24)...
December 2015: Fortschritte der Neurologie-Psychiatrie
Robin B Jarrett, Abu Minhajuddin, Jeffrey R Vittengl, Lee Anna Clark, Michael E Thase
OBJECTIVE: To determine the extent to which prospectively identified responders to cognitive therapy (CT) for recurrent major depressive disorder (MDD) hypothesized to be lower risk show significantly less relapse or recurrence than treated higher risk counterparts across 32 months. METHOD: Outpatients (N = 523), aged 18-70, with recurrent MDD received 12-14 weeks of CT. The last 7 consecutive scores from the Hamilton Rating Scale for Depression (HRSD-17) were used to stratify or define responders (n = 290) into lower (7 HRSD-17 scores of less than or equal to 6; n = 49; 17%) and higher risk (n = 241; 83%)...
April 2016: Journal of Consulting and Clinical Psychology
Agata Różycka, Radosław Słopień, Agnieszka Słopień, Jolanta Dorszewska, Agnieszka Seremak-Mrozikiewicz, Margarita Lianeri, Małgorzata Maciukiewicz, Alina Warenik-Szymankiewicz, Teresa Grzelak, Grażyna Kurzawińska, Krzysztof Drews, Andrzej Klejewski, Paweł P Jagodziński
OBJECTIVE: The aim of the study was assessment of a possible relationship between the polymorphisms of the candidate genes participating in the etiology of some neurological and psychiatric disorders and the risk of depression in perimenopausal and postmenopausal women. METHODS: A total of 167 (54 perimenopausal and 113 postmenopausal) Caucasian women from western Poland, aged 42-67, were recruited as the patient group in the study because of depressive symptoms, and another 321 healthy women (102 perimenopausal and 219 postmenopausal) served as the controls...
February 2016: Maturitas
Alexandre González-Rodríguez, Oriol Molina-Andreu, Rafael Penadés, Marina Garriga, Alexandre Pons, Rosa Catalán, Miguel Bernardo
Background and Objectives. Recent evidence supports an association between estrogen levels and severity of psychopathology in schizophrenia women. Our main goal was to investigate whether delusional disorder (DD) women with premenopausal onset and those with postmenopausal onset differ in demographic and clinical features. Methods. Psychopathological symptoms were assessed in 80 DD women (DSM-IV-TR), at baseline and after six and 24 months. Scores in the PANSS, PSP for functionality, HRSD 17 items, C-SSRS for suicide, and the SUMD were considered outcome variables...
2015: Schizophrenia Research and Treatment
Zlatan Stojanović, Sanja Vukadinović Stojanović
BACKGROUND/AIM: Emotional reactions have been documented after tumor lesions and the other damages of the brain. The aim of this paper was to examine the correlation between frontal lobe lesions and emotional reactions in patients with stroke. METHODS: The research included 118 patients after stroke. Lesion localization was defined on computed axial tomography records, whereas the area and perimeter of lesion were measured by AutoCAD 2004 software. Examinations by means of the Hamilton Rating Scale for Anxiety and Depression (HRSA and HRSD) were carried out 11-40 days after stroke...
September 2015: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
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