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Hamilton Depression

Jing Kang, Zongsheng Tian, Mingxian Li
The aim of this study was to investigate the changes in insular cortex metabolites and the correlation with clinical manifestations in patients with obstructive sleep apnea syndrome (OSA). Lateral insular metabolite levels were measured and relevant ratios were calculated in OSA patients and healthy individuals, including N-acetyl aspartate/creatine (NAA/Cr), choline/creatine (Cho/Cr), inositol/creatine (Ins/Cr), glutamate compound/creatine (Glx/Cr), N-acetyl aspartate/choline (NAA/Cho), and lactic acid (Lac)...
June 15, 2018: Neuroreport
Chunxia Yang, Aixia Zhang, Aixiang Jia, Jack X Ma, Ning Sun, Yanfang Wang, Xinrong Li, Zhifen Liu, Sha Liu, Yong Xu, Kerang Zhang
This study aims to identify and characterize neurobiological markers for major depressive disorder (MDD) from resting-state brain functional MRI. We examined the abnormality in the regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) in first-episode, drug-naive major depressive disorder (fMDD), and remitted major depressive disorder (rMDD) and correlated these fluctuations with clinical markers of MDD. We conducted a retrospective study and reviewed the medical records of 43 patients with fMDD...
June 15, 2018: Neuroreport
Tao Yang, Guoqing Zhao, Ruizhi Mao, Jia Huang, Xianrong Xu, Yousong Su, Na Zhu, Rubai Zhou, Xiao Lin, Weiping Xia, Fan Wang, Rui Liu, Xing Wang, Zhijia Huang, Yong Wang, Yingyan Hu, Lan Cao, Chengmei Yuan, Zuowei Wang, Raymond W Lam, Jun Chen, Yiru Fang
BACKGROUND: The aims of this study were to investigate the differences in executive function and the relationship with clinical factors between drug-naïve patients with bipolar depression (BDD) and unipolar depression (UPD). METHODS: Drug-naïve patients with BDD, UPD and healthy controls (HC) were recruited (30 cases in each group). All patients were assessed with Hamilton Rating Scale for Anxiety (HAM-A), Hamilton Rating Scale for Depression-17 (HAM-D), and Young Mania Rating Scale (YMRS)...
May 29, 2018: Journal of Affective Disorders
Shanshan Li, Weiqiang Zhong, Wen Peng, Gaofeng Jiang
OBJECTIVE: To assess the clinical effectiveness of acupuncture in the treatment of postpartum depression (PPD). METHODS: The following electronic databases were systematically searched: PubMed, Cochrane Library, SCI, Elsevier SDOL, China National Knowledge, Wan Fang database and Chinese Science and Technology Periodical Database. Only randomised controlled trials (RCTs) of acupuncture for PPD were considered. Primary outcomes were the Hamilton Rating Scale for Depression (HAMD) or the Edinburgh Postnatal Depression Scale (EPDS) scores and effective rate...
June 15, 2018: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
Wanpen Turakitwanakan, Patirop Pongpaplud, Maethaphan Kitporntheranunt
Background: Major depressive disorder (MDD) is the important cause of disability in the world. Major depressive patients that are not respond to the first and second drugs are about 67% and 33%, respectively. Therefore the effective treatment is urgently needed. Objective: To examine the effect of Buddhist mindfulness meditation combined with standard treatment on depression and quality of life in major depressive patient compared to the control group. Material and Method: It was a quasi experimental study...
November 2017: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Fernanda Palhano-Fontes, Dayanna Barreto, Heloisa Onias, Katia C Andrade, Morgana M Novaes, Jessica A Pessoa, Sergio A Mota-Rolim, Flávia L Osório, Rafael Sanches, Rafael G Dos Santos, Luís Fernando Tófoli, Gabriela de Oliveira Silveira, Mauricio Yonamine, Jordi Riba, Francisco R Santos, Antonio A Silva-Junior, João C Alchieri, Nicole L Galvão-Coelho, Bruno Lobão-Soares, Jaime E C Hallak, Emerson Arcoverde, João P Maia-de-Oliveira, Dráulio B Araújo
BACKGROUND: Recent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression. METHODS: To test the antidepressant effects of ayahuasca, we conducted a parallel-arm, double-blind randomized placebo-controlled trial in 29 patients with treatment-resistant depression. Patients received a single dose of either ayahuasca or placebo. We assessed changes in depression severity with the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Hamilton Depression Rating scale at baseline, and at 1 (D1), 2 (D2), and 7 (D7) days after dosing...
June 15, 2018: Psychological Medicine
Alireza Ghajar, Faezeh Gholamian, Maryam Tabatabei-Motlagh, Mohsen Afarideh, Farzin Rezaei, Maryam Ghazizadeh-Hashemi, Shahin Akhondzadeh
OBJECTIVE: We aimed to evaluate the efficacy and tolerability of citicoline add-on therapy in treatment of negative symptoms in patients with stable schizophrenia. METHODS: In a double-blind and placebo-controlled study, patients with stable schizophrenia (DSM-5) were randomized to receive either 2,500 mg/day citicoline or placebo in addition to risperidone for 8 weeks. The patients were assessed using the positive and negative syndrome scale (PANSS), the extrapyramidal symptom rating scale (ESRS), and Hamilton depression rating scale (HDRS)...
June 14, 2018: Human Psychopharmacology
Arzu Kaya, Gürkan Akgöl, Arif Gülkesen, Ahmet Kürşad Poyraz, Tülay Yildirim, Murad Atmaca
Objectives: This study aims to evaluate cerebral blood flow using color duplex Doppler ultrasonography in patients with fibromyalgia syndrome (FMS). Patients and methods: The study included 30 female patients with FMS (mean age 42.3 years; range 22 to 59 years) and 30 female healthy controls (mean age 39.6 years; range 22 to 56 years). Color duplex Doppler ultrasonography imaging was performed with an EPIQ 5 unit equipped with a multi-frequency linear probe (3-12 MHz) in the supine position...
March 2018: Archives of Rheumatology
F T Fellendorf, M Platzer, R Pilz, A Rieger, H P Kapfhammer, H Mangge, N Dalkner, S Zelzer, A Meinitzer, A Birner, S A Bengesser, R Queissner, C Hamm, R Hartleb, E Z Reininghaus
OBJECTIVES: An important aspect of bipolar disorder (BD) research is the identification of biomarkers pertaining to the somatic health state. The branched-chain essential amino acids (BCAAs), viz valine, leucine and isoleucine, have been proposed as biomarkers of an individual's health state, given their influence on protein synthesis and gluconeogenesis inhibition. METHODS: BCAA levels of 141 euthymic/subsyndromal individuals with BD and 141 matched healthy controls (HC) were analyzed by high-pressure lipid chromatography and correlated with clinical psychiatric, anthropometric and metabolic parameters...
June 14, 2018: World Journal of Biological Psychiatry
Yi-Yung Hung
OBJECTIVE: Changes in the brain's inflammatory status can lead to psychopathological responses, especially depression. Using animal models, recent studies have revealed that this pathology is due, in part, to innate immune responses of monocytes. METHODS: We focus on the involvement of Toll-like receptors (TLRs) and expression of genes encoding their negative regulators, SOCS1, TOLLIP, SIGIRR, MyD88s, NOD2, and TNFAIP3, in CD14+ monocytes from 34 patients with major depressive disorder (MDD) and 33 healthy controls before and after treatment with antidepressants...
June 13, 2018: Neuroimmunomodulation
Mauro Porcu, Regina Célia Bueno Rezende Machado, Mariana Urbano, Waldiceu A Verri, Ana Carolina Rossaneis, Heber Odebrecht Vargas, Sandra Odebrecht Vargas Nunes
Aim: To examine clinical and biomarkers in depressed female smokers, in order to better clarify the process that link mood disorders, childhood trauma and smoking in women. Methods: The clinical sample comprised women with unipolar or bipolar depression, divided into subgroups of smokers and never-smoker. The control groups comprised two subgroups non-depressed women, separated into smokers and never-smokers. A structured questionnaire was used to assess socio-demographic and clinical data...
June 2018: Addictive Behaviors Reports
Sang-Won Park, Jong-Ha Lee, Jihyun Kim, Sangil Suh, Moon-Soo Lee
BACKGROUND: Major depressive disorder (MDD) is a common mental disorder, the onset of which frequently occurs during adolescence. While differences in heart rate variability (HRV) between depressed and healthy participants have previously been observed, results have been inconsistent. This study thus investigated the features of HRV in adolescents with MDD. METHODS: We recruited first-episode drug-naïve adolescents aged 13-18 years who had been diagnosed with MDD, and healthy age-matched controls...
June 2, 2018: Journal of Affective Disorders
Joan Trujols, Javier de Diego-Adeliño, Albert Feliu-Soler, Ioseba Iraurgi, Dolors Puigdemont, Enric Álvarez, Víctor Pérez, Maria J Portella
Exploring depressive symptom severity is progressively shifting from the traditional assessment of symptom domains to detailed examination of individual symptoms. This study aimed at determining whether using an alternative scoring method (i.e., summing all scorable items instead of summing symptom domains) for the Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR16 ) would not compromise the measurement properties. This is a secondary analysis of data collected in a psychometric study of the Spanish version of the QIDS-SR16 ...
May 31, 2018: Psychiatry Research
Yong Zhang, Xingning Long, Xiaojuan Ma, Qianqian He, Xingguang Luo, Yanhui Bian, Yuanyuan Xi, Xia Sun, Chee H Ng, Eduard Vieta, Yu-Tao Xiang
OBJECTIVES: Bipolar disorder (BD) is often associated with significant functional impairment. However, there is currently no valid and reliable instrument for this variable that is both brief and easy to administer in China. We thus aimed to evaluate the psychometric properties of the Chinese version of the Functioning Assessment Short Test (FAST) in Chinese adults with BD. METHODS: In this sample of adult subjects, 176 with BD and 53 healthy controls were included...
June 5, 2018: Journal of Affective Disorders
Weifeng Peng, Lingyan Mao, Dazhi Yin, Wei Sun, He Wang, Qianqian Zhang, Jing Wang, Caizhong Chen, Mengsu Zeng, Jing Ding, Xin Wang
PURPOSE: Our study aimed to investigate the functional connectivity (FC) between the hippocampus and other brain regions in epilepsy patients with depressive symptoms. METHODS: Epilepsy patients with and without depressive symptoms, assessed using the 17-item Hamilton Depression Rating Scale scores, were enrolled. Healthy volunteers were recruited as the control group. Resting state functional magnetic resonance imaging was performed, and the data were processed using Resting-State fMRI (DPARSFA2...
June 1, 2018: Seizure: the Journal of the British Epilepsy Association
Sidney H Kennedy, Reinhard Heun, Alla Avedisova, Antti Ahokas, Valérie Olivier, Françoise Picarel-Blanchot, Christian de Bodinat
PURPOSE: The purpose of this work is to investigate the effect of agomelatine on functioning compared with placebo in patients suffering from Major Depressive Disorder (MDD). METHODS: Data from two randomized, parallel, double-blind, placebo-controlled short-term agomelatine trials conducted by the manufacturer, one in adult and one in older patients, that evaluated the effect on social functioning, were pooled. The short term effect of agomelatine on social functioning was assessed using the Sheehan Disability Scale (SDS), according to SDS total and sub-item scores, as well as on functional response and remission rates...
May 29, 2018: Journal of Affective Disorders
Jun Tu, Ling-Xiao Wang, Hong-Feng Wen, Yi-Cheng Xu, Pei-Fu Wang
The aim of this study was to investigate post-stroke depression (PSD) and cognitive impairments in patients with different types of cerebral infarction.A total of 110 patients with cerebral infarction treated in our hospital from January 2015 to February 2016 were included in present study. Forty-seven patients were PSD patients and 63 patients were non-PSD patients. The Hamilton Depression Rating Scale (HAMD) and Mini-Mental State Examination (MMSE) were employed to assess depression and cognition of patientsAmong PSD patients, the proportion of patients with partial anterior circulation infarction (PACI, 68...
June 2018: Medicine (Baltimore)
Pilar Cristancho, Nicholas T Trapp, Shan H Siddiqi, David Dixon, J Philip Miller, Eric J Lenze
Clinical trials using left-sided repetitive transcranial magnetic stimulation (rTMS) report remission rates of 14% to 32.6%. A large percentage of patients would not achieve remission with standard rTMS treatment. The question of what clinicians should do when a patient is not responding to standard high-frequency (HF) left-sided rTMS remains unanswered. This prospective case series examines whether crossover to bilateral stimulation enhances antidepressant outcomes in patients not responding to unilateral rTMS...
June 5, 2018: Journal of ECT
Danijela Vojtikiv-Samoilovska, Anita Arsovska
BACKGROUND: A depression following a stroke (Post Stoke Depression-PSD) is the most common complication of a stroke that has a negative effect on the result after the stroke. A better definition of the risk factors of the disease will provide for better prediction and treatment. AIM: To research identification of the risk factors for PSD, typical for the Macedonian population, which will help in early prediction, timely diagnosis and treatment of the disease? MATERIAL AND METHODS: We carried out a prospective study in order to determine the prevalence and the risk factors of PSD in 100 patients treated at the hospital in Tetovo...
May 20, 2018: Open Access Macedonian Journal of Medical Sciences
Danijela Vojtikiv-Samoilovska, Anita Arsovska
BACKGROUND: Although post-stroke depression (PSD) is the most common neuro-psychiatric consequence after a stroke there is still some obscurity regarding its aetiology and risk factors, which complicates its management. A better knowledge of the predictors will enable better prevention and treatment. AIM: The aim of this work was the identification of the risk factors for PSD, typical for the Macedonian population, which will help in early prediction, timely diagnosis and treatment of the disease...
May 20, 2018: Open Access Macedonian Journal of Medical Sciences
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