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https://www.readbyqxmd.com/read/29677524/effectiveness-of-community-based-depression-intervention-programme-comdip-to-manage-women-with-depression-in-primary-care-randomised-control-trial
#1
Pillaveetil Sathyadas Indu, Thekkethayyil Viswanathan Anilkumar, Krishnapillai Vijayakumar, K A Kumar, P Sankara Sarma, Saradamma Remadevi, Chittaranjan Andrade
BACKGROUND: In low and middle income countries where mental health resources are limited, community based depression intervention models, which can be implemented through the existing health system, are extremely relevant. OBJECTIVE: To test the effectiveness of Community based Depression Intervention Programme (ComDIP), newly developed by us, to reduce severity of depression in women, compared to the treatment as usual (TAU). METHODS: An RCT (Trial registration Number: CTRI/2011/08/001978, Clinical Trials Registry -India) was conducted in a primary care setting in Trivandrum, Kerala, South India...
April 3, 2018: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29676694/keyhole-strategy-aiming-at-minimizing-hospital-stay-for-surgical-clipping-of-unruptured-middle-cerebral-artery-aneurysms
#2
Kentaro Mori, Kojiro Wada, Naoki Otani, Arata Tomiyama, Terushige Toyooka, Satoru Takeuchi, Takuji Yamamoto, Yasuaki Nakao, Hajime Arai
OBJECTIVE Aneurysms of the middle cerebral artery (MCA) are still most often treated by clipping through standard craniotomy, but a longer hospital stay is one of the main drawbacks of this treatment. The authors developed a pterional keyhole clipping strategy for unruptured MCA aneurysms with the intention of minimizing hospital stay. In this paper, they report on their experience with this approach and analyze the long-term neurological and radiological outcomes. METHODS A total of 160 relatively small unruptured MCA aneurysms (mean 6...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29674268/frequency-dependent-functional-connectivity-of-the-nucleus-accumbens-during-continuous-transcutaneous-vagus-nerve-stimulation-in-major-depressive-disorder
#3
Zengjian Wang, Jiliang Fang, Jun Liu, Peijing Rong, Kristen Jorgenson, Joel Park, Courtney Lang, Yang Hong, Bing Zhu, Jian Kong
Transcutaneous vagus nerve stimulation (tVNS) may be a promising treatment for major depressive disorder (MDD). In this exploratory study, fMRI scans were acquired during continuous real or sham tVNS from 41 MDD patients. Then, all patients received real or sham tVNS treatment for four weeks. We investigated the functional connectivity (FC) of the nucleus accumbens (NAc) at different frequency bands during real and sham tVNS and explored their associations with depressive symptom changes after one month of treatment...
December 28, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29674090/oscillatory-local-field-potentials-of-the-nucleus-accumbens-and-the-anterior-limb-of-the-internal-capsule-in-heroin-addicts
#4
Shunnan Ge, Xinyi Geng, Xuelian Wang, Nan Li, Lei Chen, Xinjing Zhang, Yongzhi Huang, Yang Li, Yukun Chen, Shouyan Wang, Guodong Gao
OBJECTIVES: The nucleus accumbens (NAc) is known to regulate the motivation and underlie addictive behaviors, and the anterior limb of the internal capsule (ALIC) is involved in several psychiatric disorders. Our study aimed to explore the functions of NAc and ALIC electrophysiologically. METHODS: The local field potentials (LFPs) of the NAc and ALIC were recorded from 7 heroin addicts treated with deep brain stimulation. Correlation analysis was made between LFP powers in various frequency bands and the subjects' neuropsychological test scores; coherence was calculated for the LFPs in NAc and ALIC...
March 30, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29670190/founder-specific-inbreeding-depression-affects-racing-performance-in-thoroughbred-horses
#5
Evelyn T Todd, Simon Y W Ho, Peter C Thomson, Rachel A Ang, Brandon D Velie, Natasha A Hamilton
The Thoroughbred horse has played an important role in both sporting and economic aspects of society since the establishment of the breed in the 1700s. The extensive pedigree and phenotypic information available for the Thoroughbred horse population provides a unique opportunity to examine the effects of 300 years of selective breeding on genetic load. By analysing the relationship between inbreeding and racing performance of 135,572 individuals, we found that selective breeding has not efficiently alleviated the Australian Thoroughbred population of its genetic load...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29669617/does-a-modified-mindfulness-based-cognitive-therapy-mbct-course-have-the-potential-to-reduce-stress-and-burnout-in-nhs-gps-feasibility-study
#6
Kate Hamilton-West, Tracy Pellatt-Higgins, Neil Pillai
AimTo explore, for the first time, whether a modified mindfulness-based cognitive therapy (MBCT) course has the potential to reduce stress and burnout among National Health Service (NHS) General Practitioners. BACKGROUND: There is a crisis of low morale among NHS GPs, with most describing their workload as 'unmanageable'. MBCT has been demonstrated to improve stress and burnout in other populations, but has not yet been evaluated in a cohort of NHS GPs. METHODS: NHS GPs in South East England (n=22) attended a modified version of the MBCT course approved by National Institute for Health and Care Excellence for prevention of depressive relapse...
April 19, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29668746/early-improvement-of-executive-test-performance-during-antidepressant-treatment-predicts-treatment-outcome-in-patients-with-major-depressive-disorder
#7
Stefanie Wagner, Isabella Helmreich, Daniel Wollschläger, Konstantin Meyer, Sabine Kaaden, Julia Reiff, Sibylle C Roll, Dieter Braus, Oliver Tüscher, Florian Müller-Dahlhaus, André Tadić, Klaus Lieb
Executive dysfunctions frequently occur in patients with Major Depressive Disorder and have been shown to improve during effective antidepressant treatment. However, the time course of improvement and its relationship to treatment outcome is unknown. The aim of the study was to assess the test performance and clinical outcome by repetitive assessments of executive test procedures during antidepressant treatment. Executive test performance was assessed in 209 -patients with Major Depressive Disorder (mean age 39...
2018: PloS One
https://www.readbyqxmd.com/read/29664050/association-between-perceived-stressfulness-of-stressful-life-events-and-the-suicidal-risk-in-chinese-patients-with-major-depressive-disorder
#8
Jing-Yu Lin, Yu Huang, Yun-Ai Su, Xin Yu, Xiao-Zhen Lyu, Qi Liu, Tian-Mei Si
Background: Patients with major depressive disorder (MDD) usually have high risk of suicidality. Few studies have investigated the effects of stressful life events (SLEs) on the risk of suicide in Chinese patients who have developed MDD. This study aimed to investigate the impact of SLEs on suicidal risk in Chinese patients with MDD. Methods: In total, 1029 patients with MDD were included from nine psychiatric hospitals to evaluate the impact of SLEs on suicidal risk...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29660637/does-oral-administration-of-ketamine-accelerate-response-to-treatment-in-major-depressive-disorder-results-of-a-double-blind-controlled-trial
#9
Somaye Arabzadeh, Elham Hakkikazazi, Nazila Shahmansouri, Abbas Tafakhori, Alireza Ghajar, Morteza Jafarinia, Shahin Akhondzadeh
BACKGROUND: Major depressive disorder (MDD) exerts a high health and financial burden on society. The conventional pharmacotherapies for MDD are partially effective and the response to medication often starts with some delay. There are recent reports of antidepressant effects for oral ketamine. METHODS: We employed a double-blind controlled trial to examine the time course of the therapeutic effect of ketamine when combined with the conventional administration of sertraline...
February 22, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29659120/patterns-of-depressive-symptom-remission-during-the-treatment-of-seasonal-affective-disorder-with-cognitive-behavioral-therapy-or-light-therapy
#10
Jonah Meyerhoff, Michael A Young, Kelly J Rohan
BACKGROUND: To elucidate mechanisms related to remission in winter seasonal affective disorder (SAD), we explored the course of individual depressive symptom offset across two distinct treatment modalities that show comparable outcomes at treatment endpoint: cognitive-behavioral therapy for SAD (CBT-SAD) and light therapy (LT). METHOD: One hundred seventy-seven adults with SAD in a depressive episode were randomized to 6-weeks of CBT-SAD (n = 88) or LT (n = 89)...
April 16, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29659102/initial-severity-and-antidepressant-efficacy-for-anxiety-disorders-obsessive-compulsive-disorder-and-posttraumatic-stress-disorder-an-individual-patient-data-meta-analysis
#11
Ymkje Anna de Vries, Annelieke M Roest, Johannes G M Burgerhof, Peter de Jonge
BACKGROUND: It has been suggested that antidepressant benefits are smaller for mild than severe depression. Because antidepressants are also used for anxiety disorders, obsessive-compulsive disorder (OCD), and posttraumatic stress disorder (PTSD), we examined the influence of severity for these disorders. METHODS: We used individual patient data of eight trials (3,430 participants) for generalized anxiety disorder (GAD); four trials (1,195 participants) for social anxiety disorder (SAD); four trials (1,132 participants) for OCD; three trials (1,071 participants) for PTSD; and 10 trials (2,151 participants) for panic disorder (PD)...
April 16, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29658378/improvement-of-depressive-symptoms-in-patients-with-moderate-to-severe-psoriasis-treated-with-ustekinumab-an-open-label-trial-validated-using-beck-depression-inventory-hamilton-depression-rating-scale-measures-and-18-fluorodeoxyglucose-fdg-positron-emission
#12
Seong-Jang Kim, Min-Young Park, Kyoungjune Pak, Junhee Han, Gun-Wook Kim, Hoon-Soo Kim, Hyun-Chang Ko, Moon-Bum Kim, Byung-Soo Kim
BACKGROUND: Psoriasis is a chronic skin disease associated with psychiatric co-morbidities, especially depression. Early detection of psychological vulnerability in patients with psoriasis seems to be of great clinical importance and significantly impacts the quality of life of the patients. OBJECTIVES: We sought to clarify the association between psoriasis and depressive symptoms in patients with moderate to severe psoriasis, and to determine the risk factors for depressive symptoms and analyse the effect of ustekinumab on the symptoms...
April 16, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29657870/is-the-serum-oxytocin-level-altered-by-treatment-in-rheumatoid-arthritis-patients-complicated-with-depression
#13
Yusuke Miwa, Hidekazu Furuya, Ryo Yanai, Tsuyoshi Kasama, Kenji Sanada
Objective: The objective of this study was to investigate the factors associated with depression, including serum oxytocin (OXT) levels, disease activity, activities of daily living (ADL), and quality of life (QOL), and their effects on rheumatoid arthritis (RA). Methods: This study included 42 RA patients who received treatment with a biological agent. We measured the following variables before and after 6 months of treatment: baseline characteristics, including age, sex, disease duration, smoking, and body mass index (BMI); prednisolone and methotrexate dose; serum level of matrix metalloproteinase-3 (MMP-3); erythrocyte sedimentation rate (ESR); and C-reactive protein (CRP) level...
March 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29656414/add-on-memantine-treatment-for-bipolar-ii-disorder-comorbid-with-alcohol-dependence-a-12-week-follow-up-study
#14
Sheng-Yu Lee, Tzu-Yun Wang, Shiou-Lan Chen, Yun-Hsuan Chang, Po-See Chen, San-Yuan Huang, Nian-Sheng Tzeng, Liang-Jen Wang, I Hui Lee, Kao Ching Chen, Yen Kuang Yang, Jau-Shyong Hong, Ru-Band Lu
BACKGROUND: Bipolar disorder (BD), especially BD-II, is frequently comorbid with alcohol dependence. Because BD-II and alcohol dependence are neurodegenerative disorders, agents with anti-inflammatory and neurotrophic effects might provide effective therapy. We investigated whether add-on memantine to regular valproate (VPA) treatment ameliorated clinical symptoms, reduced alcohol use and cytokine levels, and increased plasma brain-derived neurotrophic factor (BDNF) in BD-II patients with comorbid alcohol dependence...
April 15, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29653348/increased-oxidative-stress-in-the-mitochondria-isolated-from-lymphocytes-of-bipolar-disorder-patients-during-depressive-episodes
#15
Samira S Valvassori, Daniela V Bavaresco, Gustavo Feier, Kelen Cechinel-Recco, Amanda V Steckert, Roger B Varela, Cenita Borges, Milena Carvalho-Silva, Lara M Gomes, Emílio L Streck, João Quevedo
The present study aims to investigate the oxidative stress parameters in isolated mitochondria, as well as looking at mitochondrial complex activity in patients with Bipolar Disorder (BD) during depressive or euthymic episodes. This study evaluated the levels of mitochondrial complex (I, II, II-III and IV) activity in lymphocytes from BD patients. We evaluated the following oxidative stress parameters: superoxide, thiobarbituric acid reactive species (TBARS) and carbonyl levels in submitochondrial particles of lymphocytes from bipolar patients...
April 4, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29652947/-predictors-of-remission-from-major-depressive-disorder-in-secondary-care
#16
Lilian Salvo, Sandra Saldivia, Carlos Parra, Manuel Cifuentes, Claudio Bustos, Paola Acevedo, Marcela Díaz, Mitza Ormazabal, Ivonne Guerra, Nicol Navarrete, Verónica Bravo, Andrea Castro
Background The knowledge of predictive factors in depression should help to deal with the disease. Aim To assess potential predictors of remission of major depressive disorders (MDD) in secondary care and to propose a predictive model. Material and Methods A 12 month follow-up study was conducted in a sample of 112 outpatients at three psychiatric care centers of Chile, with baseline and quarterly assessments. Demographic, psychosocial, clinical and treatment factors as potential predictors, were assessed. A clinical interview with the checklist of DSM-IV diagnostic criteria, the Hamilton Depression Scale and the List of Threatening Experiences and Multidimensional Scale of Perceived Social Support were applied...
December 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29652307/-therapy-of-asthenoneurotic-syndrome-in-patients-with-focal-muscular-dystonia
#17
V A Suvorova, E A Antipenko
AIM: To analyze the prevalence and structure of asthenoneurotic disorders in patients with focal muscular dystonia and determine an effect of the anxiolytic аdaptol (tetramethyltetraazabicyclooctandion) on asthenic syndrome in muscular dystonia. MATERIAL AND METHODS: Forty patients with focal muscular dystonia were examined. The severity of asthenic syndrome (MFI-20), anxiety (the Hospital scale of anxiety and depression) and depression (the Hamilton Depression Rating Scale) were evaluated...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29652306/-assessment-of-clinical-manifestations-and-treatment-of-post-stroke-depression-in-young-patients-with-ischemic-stroke
#18
M L Chukhlovina, A A Chukhlovin
AIM: To consider clinical manifestations and treatment of post-stroke depression in young patients with carotid ischemic stroke. MATERIAL AND METHODS: Forty patients, 24 women and 16 men, aged from 18 to 45 years old, diagnosed with ICD-10 post-stroke depression were examined. All patients underwent neurological examination, brain MRI and MR-angiography of cerebral vessels. The following psychometric tests were used: MMSE, Hamilton depression scale, CES-D depression scale, a questionnaire on nocturnal sleep assessment, and Epworth Sleepiness Scale...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29649674/are-there-clinical-and-neurophysiologic-predictive-factors-for-a-positive-response-to-hf-rtms-in-patients-with-treatment-resistant-depression
#19
Anna Poleszczyk, Maria Rakowicz, Tadeusz Parnowski, Jakub Antczak, Łukasz Święcicki
Better selection of patients with treatment-resistant depression for high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) would make the procedure more efficient. The objective of this study was to search for clinical and neurophysiologic predictors of therapeutic response with a special focus on the bipolar population. Forty patients (30 bipolar) underwent 20 daily sessions of HF-rTMS. Clinical outcome measures included the 21-item Hamilton Depression Rating Scale, the Beck Depression Inventory, the Clinical Global Impression, and the Patient Global Impression...
April 3, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29643931/remission-in-depression-and-associated-factors-at-different-assessment-times-in-primary-care-in-chile
#20
Veronica Vitriol, Alfredo Cancino, Carlos Serrano, Soledad Ballesteros, Soledad Potthoff
Objective: To determine the factors associated with remission at 3, 6, 9 and 12 months among depressive adult patients in primary care [PHC] in Chile. Methods: This is a one-year naturalistic study that followed 297 patients admitted for treatment of depression in eight primary care clinics in Chile. Initially, patients were evaluated using: the International Mini-Neuropsychiatric Interview [MINI], a screening for Childhood Trauma Events [CTEs], the Life Experiences Survey and a partner violence scale...
2018: Clinical Practice and Epidemiology in Mental Health: CP & EMH
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