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Hamilton Depression

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https://www.readbyqxmd.com/read/29035935/prevalence-and-correlations-between-suicide-attempt-depression-substance-use-and-functionality-among-patients-with-limb-amputations
#1
Pedro I Arias Vázquez, Rosa G Castillo Avila, Mayra Del C Dominguez Zentella, Yazmín Hernández-Díaz, Thelma B González-Castro, Carlos A Tovilla-Zárate, Isela E Juárez-Rojop, María L López-Narváez, Ana Frésan
Most patients undergoing limb amputations suffer significant emotional changes. The aim of this study was to estimate the prevalence of suicide attempts and depression in a sample of Mexican patients with limb amputations and, second, to determine whether the patients' functionality correlates with the presence of depression. We studied 40 patients who had undergone a limb amputation. The suicide attempt was evaluated using the Suicide Intent Scale. The depression was assessed using the Hamilton Depression Rating Scale, whereas the functionality of the patients was measured using the Functional Independence Measure...
October 13, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/29033859/multi-watt-near-infrared-phototherapy-for-the-treatment-of-comorbid-depression-an-open-label-single-arm-study
#2
Theodore A Henderson, Larry D Morries
BACKGROUND: The treatment of depression has been hampered by low efficacy of antidepressant medications and safety concerns with alternative modalities. Recent work demonstrated that multi-Watt transcranial near-infrared light therapy (NILT) can effectively treat traumatic brain injury (TBI). The current objective is to explore multi-Watt NILT efficacy in a proof-of-concept study as a treatment for depression. METHODS: Thirty-nine sequential patients treated for TBI between March 2013 and May 2017 provided depression self-assessment data and/or were administered the Hamilton depression rating scale...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29033569/associations-among-depression-severity-painful-physical-symptoms-and-social-and-occupational-functioning-impairment-in-patients-with-major-depressive-disorder-a-3-month-prospective-observational-study
#3
Eiji Harada, Yoichi Satoi, Atsushi Kuga, Hirofumi Tokuoka, Toshiaki Kikuchi, Koichiro Watanabe, Levent Alev, Masaru Mimura
PURPOSE: To investigate associations among depression severity, painful physical symptoms (PPS), and social and occupational functioning impairment in patients with major depressive disorder (MDD) who had achieved complete remission (CR) or partial remission (PR) after acute treatment. PATIENTS AND METHODS: This was a 12-week, multicenter, prospective, observational study. Patients with MDD treated with an antidepressant medication for the previous 12 weeks (±3 weeks) who had achieved CR (defined as a 17-item Hamilton Rating Scale for Depression [HAM-D17] score ≤7) or PR (HAM-D17 score ≥8 and ≤18) were enrolled...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29033483/the-impact-of-antidepressant-treatment-on-brain-derived-neurotrophic-factor-level-an-evidence-based-approach-through-systematic-review-and-meta-analysis
#4
Vijayakumar Arumugam, Vini Susan John, Nisha Augustine, Taniya Jacob, Sagar Maliakkal Joy, Suchandra Sen, Tuhinadri Sen
OBJECTIVES: Antidepressant treatment alters brain-derived neurotrophic factor (BDNF) levels, but it is not well established whether BDNF can be used as a marker to prove the efficacy of antidepressant treatment. The present systematic review and meta-analysis aim at assessing the influence of antidepressant treatment on BDNF level and the Hamilton Depression Rating Scale (HDRS) score, thereby to establish the rationale of utilizing BDNF as a predictive biomarker and HDRS score as an indicator for antidepressant treatment efficacy...
May 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29031182/translating-the-ham-d-into-the-madrs-and-vice-versa-with-equipercentile-linking
#5
Stefan Leucht, Hein Fennema, Rolf R Engel, Marion Kaspers-Janssen, Armin Szegedi
BACKGROUND: The Hamilton Depression Rating Scale (HAM-D) and the Montgomery Asberg Depression Rating Scale (MADRS) are scales used frequently to rate the symptoms of depression. There are many situations in which it is important to know what a given total score or a percent reduction from baseline score of one scale means in relation to the other scale. METHOD: We used the equipercentile linking method to identify corresponding scores of simultaneous HAM-D and MADRS ratings in 4388 patients from 31 mirtazapine trials in major depressive disorder...
September 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29028593/genetic-variations-in-the-p11-tpa-bdnf-pathway-are-associated-with-post-stroke-depression
#6
Jinfeng Liang, Yingying Yue, Haitang Jiang, Deqin Geng, Jun Wang, Jianxin Lu, Shenghua Li, Kezhong Zhang, Aiqin Wu, Yonggui Yuan
BACKGROUND: The effects of BDNF on post stroke depression (PSD) may be influenced by genetic variations in intracellular signal transduction pathways, such as the p11/tPA/BDNF pathway. In this study, we aimed to determine the association of polymorphisms in candidate genes of the gene transduction pathway with PSD, as well as the effects of the interactions between genes in our Chinese sample. METHODS: Two-hundred-fifty-four Chinese samples with acute ischaemic stroke included 122 PSD patients and 132 nonPSD patients...
September 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29026789/the-impact-of-the-predictive-nursing-education-process-on-degree-of-comfort-and-quality-of-life-for-patients-in-the-oncology-department
#7
Yan Yu, Lijuan Hu, Xingu Chen, Mei Ge, Huijuan Zhu, Yusheng Yan
BACKGROUND: We investigated the application of a predictive nursing education process on the degree of comfort and quality of life for cancer patients. METHODS: A total of 168-cancer patient in Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China between June 2014 and June 2016 were enrolled and admitted for surgery or radiotherapy/chemotherapy treatment. Patients were randomly divided into control and observation groups, each containing 84 cases...
September 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29021442/the-relationship-between-the-serum-oxytocin-levels-disease-activity-the-adls-and-the-qol-in-patients-with-rheumatoid-arthritis
#8
Yusuke Miwa, Hidekazu Furuya, Ryo Yanai, Tsuyoshi Kasama, Kenji Sanada
Objective To investigate the factors associated with depression, including the serum oxytocin (OXT) levels, disease activity, activities of daily living (ADLs) and quality of life (QOL), and their effects on rheumatoid arthritis (RA). Methods This study included 42-RA-patients. We measured the following variables before and after 6 months of treatment with biological disease-modifying anti rheumatic drugs (bDMARDs): the baseline characteristics (including age, sex, disease duration, smoking, and body mass index), the doses of prednisolone and methotrexate, the serum level of matrix metalloprotease-3, the erythrocyte sedimentation rate and the C-reactive protein level...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29017589/randomized-trial-of-telephone-versus-in-person-delivery-of-a-brief-psychosocial-intervention-in-post-stroke-depression
#9
Catherine J Kirkness, Kevin C Cain, Kyra J Becker, David L Tirschwell, Ann M Buzaitis, Pamela L Weisman, Sylvia McKenzie, Linda Teri, Ruth Kohen, Richard C Veith, Pamela H Mitchell
BACKGROUND: A psychosocial behavioral intervention delivered in-person by advanced practice nurses has been shown effective in substantially reducing post-stroke depression (PSD). This follow-up trial compared the effectiveness of a shortened intervention delivered by either telephone or in-person to usual care. To our knowledge, this is the first of current behavioral therapy trials to expand the protocol in a new clinical sample. 100 people with Geriatric Depression Scores ≥ 11 were randomized within 4 months of stroke to usual care (N = 28), telephone intervention (N = 37), or in-person intervention (N = 35)...
October 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28992587/aberrant-resting-state-cerebellar-blood-flow-in-major-depression
#10
Malte S Depping, Nadine D Wolf, Nenad Vasic, Zrinka Sosic-Vasic, Mike M Schmitgen, Fabio Sambataro, Robert C Wolf
BACKGROUND: Abnormal cortical cerebral blood flow and gray matter volume have been frequently reported in patients with major depressive disorder (MDD). In contrast, although the role of the cerebellum in MDD pathophysiology has attracted considerable interest more recently, studies investigating both functional and structural aspects of cerebellar integrity are scarce. METHODS: In this study, we used structural and functional magnetic resonance imaging (MRI) to investigate cerebellar volume and regional cerebellar blood flow (rCBF) at rest in clinically acute MDD patients (n = 22) and healthy controls (n = 18)...
September 28, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28992526/improved-efficacy-with-targeted-pharmacogenetic-guided-treatment-of-patients-with-depression-and-anxiety-a-randomized-clinical-trial-demonstrating-clinical-utility
#11
Paul Bradley, Michael Shiekh, Vishaal Mehra, Keith Vrbicky, Stacey Layle, Marilyn C Olson, Alejandra Maciel, Ali Cullors, Jorge A Garces, Andrew A Lukowiak
The objective of this study was to evaluate the effect of pharmacogenetics-guided treatment on patients diagnosed with depression and/or anxiety, in a diverse set of clinical settings, as compared to the standard of care. The trial design followed a prospective, randomized, subject- and rater-blinded approach enrolling 685 patients from clinical providers specializing in Psychiatry, Internal Medicine, Obstetrics & Gynecology, and Family Medicine. The NeuroIDgenetix(®) test uses a genetic variant panel of ten genes, along with concomitant medications, to make medication management recommendations based on gene-drug and drug-drug interactions for over 40 medications used in the treatment of depression and anxiety...
September 23, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28988547/systematic-review-of-the-efficacy-of-non-pharmacological-interventions-in-people-with-lewy-body-dementia
#12
Hamilton Morrin, Ton Fang, Donald Servant, Dag Aarsland, Anto P Rajkumar
BACKGROUND: Pharmacological interventions for Lewy body dementia (LBD), especially for its non-cognitive symptoms, are limited in their efficacy and tolerability. Clinicians are often uncertain about non-pharmacological interventions and their efficacy in managing cognitive and non-cognitive symptoms of LBD. Therefore, we aimed to systematically review the existing literature on non-pharmacological interventions for people with LBD. METHODS: We carried out a systematic search using six databases...
October 9, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28985587/cerebrospinal-fluid-d-serine-concentrations-in-major-depressive-disorder-negatively-correlate-with-depression-severity
#13
Sayuri Ishiwata, Kotaro Hattori, Daimei Sasayama, Toshiya Teraishi, Tomoko Miyakawa, Yuuki Yokota, Ryo Matsumura, Toru Nishikawa, Hiroshi Kunugi
BACKGROUND: D-serine is an endogenous co-agonist of N-methyl-D-aspartate receptor (NMDAR) and plays an important role in glutamate neurotransmission. Several studies suggested the possible involvement of D-serine related in the pathophysiology of psychiatric disorders including major depression disorders (MDD). We tried to examine whether cerebrospinal fluid (CSF) or plasma D-serine concentrations are altered in MDD and whether D-serine concentrations correlated with disease severity...
September 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28982121/short-term-efficacy-and-tolerability-of-venlafaxine-extended-release-in-adults-with-generalized-anxiety-disorder-without-depression-a-meta-analysis
#14
Xinyuan Li, Lijun Zhu, Yingying Su, Shaokuan Fang
BACKGROUND: Although efficacy of venlafaxine extended release (XR) for generalized anxiety disorder (GAD) has been reported in previous analyses in 2002 and 2004, the sample size was rather small and estimate of safety or tolerability was not clear. The present analysis had the advantage of large sample size and provided evidence for tolerability. METHODS: Literature databases were searched, including Pubmed, Embase, Cochrane Central Register of Controlled Trials, Web of science and clinical trials...
2017: PloS One
https://www.readbyqxmd.com/read/28977521/the-impact-of-bdnf-polymorphisms-on-suicidality-in-treatment-resistant-major-depressive-disorder-a-european-multicenter-study
#15
Alexandra Schosser, Laura Carlberg, Raffaella Calati, Alessandro Serretti, Isabel Massat, Christoph Spindelegger, Sylvie Linotte, Julien Mendlewicz, Daniel Souery, Joseph Zohar, Stuart Montgomery, Siegfried Kasper
Background: Numerous studies have reported associations between the brain-derived neurotrophic factor (BDNF) gene and psychiatric disorders, including suicidal behavior, although with conflicting results. Methods: A total of 250 major depressive disorder patients were collected in the context of a European multicenter resistant depression study and treated with antidepressants at adequate doses for at least 4 weeks. Suicidality was assessed using the Mini International Neuropsychiatric Interview and Hamilton Rating Scale for Depression, and treatment response using the HAM-D...
October 1, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28974247/the-long-term-effect-of-acupuncture-for-patients-with-chronic-tension-type-headache-study-protocol-for-a-randomized-controlled-trial
#16
Lingyun Lu, Hui Zheng, Qianhua Zheng, Xinyu Hao, Siyuan Zhou, Shusen Zhang, Tao Wei, Tao Gao, Duoxi Duan, Ling Zhao, Ning Li, Ying Li
BACKGROUND: The effectiveness of acupuncture for patients with chronic tension-type headache (CTTH) is controversial. In this article, we report the protocol for a randomized controlled trial aiming to evaluate the long-term effect of acupuncture for CTTH, in comparison with superficial acupuncture. DESIGN: A two-armed, parallel-design, patient-assessor blind, randomized controlled trial is underway in China. A total of 218 participants with CTTH will be randomly assigned to the treatment group or the control group in a 1:1 ratio...
October 3, 2017: Trials
https://www.readbyqxmd.com/read/28969487/brain-structural-network-topological-alterations-of-the-left-prefrontal-and-limbic-cortex-in-psychogenic-erectile-dysfunction
#17
Jianhuai Chen, Yun Chen, Qingqiang Gao, Guotao Chen, Yutian Dai, Zhijian Yao, Qing Lu
Despite increasing understanding of the cerebral functional changes and structural abnormalities in erectile dysfunction, alterations in the topological organization of brain networks underlying psychogenic erectile dysfunction (pED) remain unclear. Here, based on the diffusion tensor image data of 25 pED patients and 26 healthy controls, we investigated the topological organization of brain structural networks and its correlations with the clinical variables using the graph theoretical analysis. Psychogenic ED displayed a preserved overall small-world organization and exhibited a less connectivity strength in the left inferior frontal gyrus, amygdale and the right inferior temporal gyrus...
October 2, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28969441/the-effect-of-a-single-dose-of-intravenous-ketamine-on-suicidal-ideation-a-systematic-review-and-individual-participant-data-meta-analysis
#18
Samuel T Wilkinson, Elizabeth D Ballard, Michael H Bloch, Sanjay J Mathew, James W Murrough, Adriana Feder, Peter Sos, Gang Wang, Carlos A Zarate, Gerard Sanacora
OBJECTIVE: Suicide is a public health crisis with limited treatment options. The authors conducted a systematic review and individual participant data meta-analysis examining the effects of a single dose of ketamine on suicidal ideation. METHOD: Individual participant data were obtained from 10 of 11 identified comparison intervention studies that used either saline or midazolam as a control treatment. The analysis included only participants who had suicidal ideation at baseline (N=167)...
October 3, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28969439/improving-the-efficiency-of-psychotherapy-for-depression-computer-assisted-versus-standard-cbt
#19
Michael E Thase, Jesse H Wright, Tracy D Eells, Marna S Barrett, Stephen R Wisniewski, G K Balasubramani, Paul McCrone, Gregory K Brown
OBJECTIVE: The authors evaluated the efficacy and durability of a therapist-supported method for computer-assisted cognitive-behavioral therapy (CCBT) in comparison to standard cognitive-behavioral therapy (CBT). METHOD: A total of 154 medication-free patients with major depressive disorder seeking treatment at two university clinics were randomly assigned to either 16 weeks of standard CBT (up to 20 sessions of 50 minutes each) or CCBT using the "Good Days Ahead" program...
October 3, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28969438/adjunctive-bright-light-therapy-for-bipolar-depression-a-randomized-double-blind-placebo-controlled-trial
#20
Dorothy K Sit, James McGowan, Christopher Wiltrout, Rasim Somer Diler, John Jesse Dills, James Luther, Amy Yang, Jody D Ciolino, Howard Seltman, Stephen R Wisniewski, Michael Terman, Katherine L Wisner
OBJECTIVE: Patients with bipolar disorder have recurrent major depression, residual mood symptoms, and limited treatment options. Building on promising pilot data, the authors conducted a 6-week randomized double-blind placebo-controlled trial to investigate the efficacy of adjunctive bright light therapy at midday for bipolar depression. The aims were to determine remission rate, depression symptom level, and rate of mood polarity switch, as well as to explore sleep quality. METHOD: The study enrolled depressed adults with bipolar I or II disorder who were receiving stable dosages of antimanic medication (excluding patients with hypomania or mania, mixed symptoms, or rapid cycling)...
October 3, 2017: American Journal of Psychiatry
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