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Hamilton Depression

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https://www.readbyqxmd.com/read/28635540/reduced-serum-vgf-levels-were-reversed-by-antidepressant-treatment-in-depressed-patients
#1
Haitang Jiang, Suzhen Chen, Na Lu, Yingying Yue, Yingying Yin, Yuqun Zhang, Wenhao Jiang, Jinfeng Liang, Yonggui Yuan
OBJECTIVES: VGF, a non-acronymic neuropeptide, is important in the pathogenesis of major depressive disorder (MDD) and in the functioning and efficacy of some antidepressant drugs. In this study we assessed whether serum VGF levels change in MDD patients and if antidepressant treatments can restore these changes. METHODS: We measured serum VGF concentrations using sandwich ELISA in drug-free MDD patients before treatment began (n = 26) and at 8 weeks after antidepressant treatment (n = 26) with escitalopram and duloxetine, two common antidepressants...
September 22, 2016: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28631869/lateralized-hippocampal-volume-increase-following-high-frequency-left-prefrontal-repetitive-transcranial-magnetic-stimulation-in-patients-with-major-depression
#2
Shunsuke Hayasaka, Motoaki Nakamura, Yoshihiro Noda, Takuji Izuno, Takashi Saeki, Hideo Iwanari, Yoshio Hirayasu
AIM: Repetitive transcranial magnetic stimulation (rTMS) has been applied as a treatment for patients with treatment-resistant depression in recent years, and a large body of evidence has demonstrated its therapeutic efficacy through stimulating neuronal plasticity. The aim of this study was to investigate structural alterations in the hippocampus (HIPP) and amygdala (AM) following conventional rTMS in patients with depression. METHODS: Twenty-eight patients with depression underwent 10 daily 20-Hz left prefrontal rTMS over 2 weeks...
June 20, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28631695/-chronic-stress-and-mental-disorders-in-patients-with-systemic-scleroderma-results-of-an-interdisciplinary-study
#3
O F Seravina, T A Lisitsyna, M N Starovoytova, O V Desinova, O B Kovalevskaya, D Yu Veltishchev
AIM: To analyze of the prevalence of stressful factors and mental disorders (MDs), as well as their clinical psychopathological and clinical psychological characteristics to improve the comprehensive diagnosis and treatment of systemic scleroderma (SSD). SUBJECTS AND METHODS: Examinations were performed in 110 patients (predominantly women (n=97 (88.2%); mean age, 49.9±2.47 years) with a documented diagnosis of SSD (its mean duration, 7.25±0.42 years). 62 (56...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28629742/statistical-differences-in-the-white-matter-tracts-in-subjects-with-depression-by-using-different-skeletonized-voxel-wise-analysis-approaches-and-dti-fitting-procedures
#4
Maurizio Bergamino, Madison Farmer, Hung-Wen Yeh, Elisabeth Paul, J Paul Hamilton
Major depressive disorder (MDD) is one of the most significant contributors to the global burden of illness. Diffusion tensor imaging (DTI) is a procedure that has been used in several studies to characterize abnormalities in white matter (WM) microstructural integrity in MDD. These studies, however, have provided divergent findings, potentially due to the large variety of methodological alternatives available in conducting DTI research. In order to determine the importance of different approaches to coregistration of DTI-derived metrics to a standard space, we compared results from two different skeletonized voxel-wise analysis approaches: the standard TBBS pipeline and the Advanced Normalization Tools (ANTs) approach incorporating a symmetric image normalization (SyN) algorithm and a group-wise template (ANTs TBSS)...
June 16, 2017: Brain Research
https://www.readbyqxmd.com/read/28629293/clinical-efficacy-and-safety-of-the-shugan-jieyu-capsule-in-patients-with-acute-myocardial-infarction-and-depression
#5
Wei Liu, Jun Qin
Objective The aim is to comparatively study Shugan Jieyu capsule and sertraline for non-inferiority in the treatment of patients with acute myocardial infarction and depression (observing the curative effects and safety) by the randomized controlled experiment. Methods A total of 149 patients with acute myocardial infarction and depression were randomly divided into two groups, the Shugan Jieyu group (76 cases) and the sertraline group (73 cases), and received treatments for 24 weeks. Depression states were assessed by the rote diagnostic checklist, and effects were evaluated by the Hamilton depression scale...
August 2016: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/28629284/anxiety-leads-to-up-regulation-of-cd36-on-the-monocytes-of-chronic-hepatitis-b-infected-patients
#6
Mohammad Hosein Bakhshi Aliabad, Elham Jafari, Mansoureh Karimi Kakh, Reza Nosratababadi, Hamid Bakhshi, Mohammad Hassan Sheikhha, Reza Bidaki, Azade Askari, Mohammad Kazemi Arababadi
Introduction It has been hypothesized that mental disorders including depression and anxiety can affect immune responses. The study was done to evaluate the relation between depression and anxiety and expression levels of CD36, CD68, and CD9 on peripheral blood monocytes of chronic hepatitis B (CHB) patients. Methods Sixty CHB patients were selected with various ranges of depression and anxiety. Depression and anxiety were evaluated using a standard questionnaire by an expert psychiatrist according to BECK's Depression Inventory II and Hamilton Anxiety Rating Scale, respectively...
July 2016: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/28627912/cognitive-behavioral-versus-psychodynamic-therapy-for-major-depression-secondary-outcomes-of-a-randomized-clinical-trial
#7
Ellen Driessen, Henricus L Van, Jaap Peen, Frank J Don, Jos W R Twisk, Pim Cuijpers, Jack J M Dekker
OBJECTIVE: In a randomized clinical trial, we compared the efficacy of cognitive-behavioral therapy (CBT) and psychodynamic therapy for adult outpatient depression on measures of psychopathology, interpersonal functioning, pain, and quality of life. METHOD: There were 341 Dutch adults (70.1% female, mean age = 38.9, SD = 10.3) meeting Diagnostic and Statistical Manual for Mental Disorders-Fourth Edition (DSM-IV) criteria for a major depressive episode and with a Hamilton Depression Rating Scale (HAM-D) score ≥14, who were randomized to 16 sessions of individual manualized CBT or short-term psychodynamic supportive psychotherapy...
July 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28627776/the-comt-val-108-158-met-genetic-polymorphism-can-not-be-recommended-as-a-biomarker-of-prediction-of-venlafaxine-efficacy-in-patients-treated-in-psychiatric-settings
#8
Adela Taranu, Khalil El Asmar, Romain Colle, Florian Ferreri, Mircea Polosan, Denis David, Laurent Becquemont, Emmanuelle Corruble, Céline Verstuyft
The antidepressant venlafaxine is known to increase the turn-over of cerebral monoamines, which are catabolized by the cathecol-O-methyltransferase (COMT). The COMT (Val108/158Met, rs4680) genetic polymorphism affects the cerebral COMT activity. But whether this genetic polymorphism is associated with response to venlafaxine remains unclear. We assessed the impact of the COMT Val(108/158)Met, rs4680 genetic polymorphism on the efficacy of venlafaxine in depressed patients. This study was nested in the METADAP cohort, a real-world naturalistic treatment study in psychiatric settings...
June 19, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28626097/-visceral-sensitivity-gut-barrier-function-and-autonomic-nerve-function-in-patients-with-diarrhea-predominant-irritable-bowel-syndrome
#9
Xiaojuan Xu, Liang Liu, Shukun Yao, Yanli Zhang
To evaluate visceral sensitivity, gut barrier function and autonomic nerve function (ANF) in patients with diarrhea-predominant irritable bowel syndrome (IBS-D), and to explore their roles in IBS-D pathophysiology.
 Methods: A total of 46 IBS-D patients (IBS-D group) were selected from the Department of Gastroenterology of China-Japan Friendship Hospital from October 2015 to March 2016, and 20 healthy volunteer were served as a control group (HC group). Clinical and psychological symptoms were evaluated by questionnaire, and visceral sensitivity to rectal balloon distention, gut barrier function and autonomic nerve function (ANF) were examined...
May 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28622208/duloxetine-plasma-concentrations-and-its-effectiveness-in-the-treatment-of-nonorganic-chronic-pain-in-the-orofacial-region
#10
Yuka Kobayashi, Wataru Nagashima, Tatsuya Tokura, Keizo Yoshida, Eri Umemura, Tomoya Miyauchi, Munetaka Arao, Mikiko Ito, Hiroyuki Kimura, Kenichi Kurita, Norio Ozaki
OBJECTIVE: The purpose of this study was to examine the relationship between the pain-relieving effects of duloxetine and its plasma concentrations in patients with burning mouth syndrome and atypical odontalgia characterized by chronic nonorganic pain in the orofacial region. METHODS: We administered duloxetine to 77 patients diagnosed as having burning mouth syndrome or atypical odontalgia for 12 weeks. The initial dose of duloxetine was established as 20 mg/d and was increased to 40 mg/d after week 2...
June 16, 2017: Clinical Neuropharmacology
https://www.readbyqxmd.com/read/28619476/brexanolone-sage-547-injection-in-post-partum-depression-a-randomised-controlled-trial
#11
Stephen Kanes, Helen Colquhoun, Handan Gunduz-Bruce, Shane Raines, Ryan Arnold, Amy Schacterle, James Doherty, C Neill Epperson, Kristina M Deligiannidis, Robert Riesenberg, Ethan Hoffmann, David Rubinow, Jeffrey Jonas, Steven Paul, Samantha Meltzer-Brody
BACKGROUND: Post-partum depression is a serious mood disorder in women that might be triggered by peripartum fluctuations in reproductive hormones. This phase 2 study investigated brexanolone (USAN; formerly SAGE-547 injection), an intravenous formulation of allopregnanolone, a positive allosteric modulator of γ-aminobutyric acid (GABAA) receptors, for the treatment of post-partum depression. METHODS: For this double-blind, randomised, placebo-controlled trial, we enrolled self-referred or physician-referred female inpatients (≤6 months post partum) with severe post-partum depression (Hamilton Rating Scale for Depression [HAM-D] total score ≥26) in four hospitals in the USA...
June 12, 2017: Lancet
https://www.readbyqxmd.com/read/28617831/depression-in-dementia-with-lewy-bodies-a-comparison-with-alzheimer-s-disease
#12
Pai-Yi Chiu, Chein-Wei Wang, Chun-Tang Tsai, Shin-Hua Li, Chih-Li Lin, Te-Jen Lai
BACKGROUND: Depression is highly associated with dementia, and this study will compare the frequencies, severity, and symptoms of depression between dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). METHODS: Frequency of depression was determined according to the DSM-IV criteria for major depression or the National Institute of Mental Health criteria for depression in AD (NIMH-dAD). Severity of depression were assessed using the Hamilton Depression Rating Scale, the Cornell Scale for Depression in Dementia, and the depression subscale in Neuropsychiatric Inventory...
2017: PloS One
https://www.readbyqxmd.com/read/28617544/the-relationship-between-quality-of-life-and-clinical-phenotype-in-patients-with-treatment-resistant-and-non-treatment-resistant-depression
#13
J Qiao, L-J Qian, H-F Zhao, G-H Gong, D-Q Geng
OBJECTIVE: The purpose of this investigation is to determine the differences in quality of life (QOL) and clinical phenotype between patients with treatment resistant (TRD) and non-treatment resistant depression (NTRD). PATIENTS AND METHODS: The severity, QOL, and cognitive function of 107 TRD and 173 NTRD patients were evaluated and calculated by the Hamilton Depression Scale-17 (HAMD-17), the 36-Item Short Form Health Survey (SF-36), and the P300 component of event-related potentials (ERP), respectively...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28615771/comparative-study-of-psychiatric-manifestations-among-type-i-and-type-ii-diabetic-patients
#14
Rupesh Chaudhary, Pankaj Kumar, Akhil Chopra, Sandeep Chabbra, Parminder Singh
BACKGROUND: Anxiety and depressive disorders belong to the most common psychiatric disorders worldwide. They are generally seen in individuals who suffer from chronic diseases, such as diabetes mellitus (DM). The prevalence of depression among diabetics ranges from 8.5% to 32.5%, while that for anxiety it is up to 30%. In this study, we try to compare the mental health problems faced by those with Type I and Type II DM. MATERIALS AND METHODS: Fifty patients diagnosed with Type I diabetes (T1D) and Type II diabetes each presenting to Medicine and Endocrinology Department were assessed with Hamilton Depression Rating Scale (HAM-D) for depression and Hamilton Anxiety Rating Scale (HAM-A) for anxiety...
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28614492/clinical-improvement-in-patients-with-borderline-personality-disorder-after-treatment-with-repetitive-transcranial-magnetic-stimulation-preliminary-results
#15
Julian Reyes-López, Josefina Ricardo-Garcell, Gabriela Armas-Castañeda, María García-Anaya, Iván Arango-De Montis, Jorge J González-Olvera, Francisco Pellicer
Objective: Current treatment of borderline personality disorder (BPD) consists of psychotherapy and pharmacological interventions. However, the use of repetitive transcranial magnetic stimulation (rTMS) could be beneficial to improve some BPD symptoms. The objective of this study was to evaluate clinical improvement in patients with BPD after application of rTMS over the right or left dorsolateral prefrontal cortex (DLPFC). Method: Twenty-nine patients with BPD from the National Institute of Psychiatry, Mexico, were randomized in two groups to receive 15 sessions of rTMS applied over the right (1 Hz, n=15) or left (5 Hz, n=14) DLPFC...
June 12, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28610254/three-new-macropsini-hemiptera-cicadellidae-leafhopper-species-from-australia
#16
Liyuan Yang, Christopher H Dietrich, Yalin Zhang
Three new species, Macropsella recta, Toropsis minuspina and Varicopsella apecurvata spp. nov. are described and illustrated from Australia.       Leafhoppers of the subfamily Macropsinae are found abundantly in the Holarctic, Oriental and Australian regions (Linnavuori, 1978) and have been collected from around the world, except for Antarctica, Oceania and South America (Hamilton, 1980). Both Hamilton (1980) and Evans (1966) suggested that there were likely a myriad of uncollected and undescribed species in Australia alone and Evans (1971) commented that the Macropsinae are possibly more abundant in Australia than anywhere else in the world...
June 2, 2017: Zootaxa
https://www.readbyqxmd.com/read/28606500/is-there-a-specific-psychiatric-background-or-personality-profile-in-functional-dystonia
#17
Aleksandra Tomić, Igor Petrović, Danilo Pešić, Marija Mitković Vončina, Marina Svetel, Nataša Dragašević Mišković, Aleksandra Potrebić, Dušica Lečić Toševski, Vladimir S Kostić
OBJECTIVE: The aim of this cross-sectional study was to identify if there was a specific difference between patients with functional dystonia (DysF) and those with adult-onset, isolated idiopathic ("primary") dystonia (DysP) in terms of psychiatric disorders, psychological stressor, dissociation correlates, and personality traits. METHODS: Thirty-nine clinically definite DysF and 30 DysP patients matched by age, gender and dystonia distribution underwent psychiatric interview based on DSM-5 criteria and additional testings for global cognitive and psychiatric functions (Mini-Mental State Examination, Hamilton Depression and Hamilton Anxiety Rating Scale, Apathy Scale, Somatoform Dissociation Questionnaire-20, Dissociative Experiences Scale II, and the five-dimensional Revised Neuroticism-Extroversion-Openness Personality Inventory)...
June 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28605527/effect-of-transcranial-direct-current-stimulation-of-the-motor-cortex-on-visceral-pain-in-patients-with-hepatocellular-carcinoma
#18
Nagwa Mostafa Ibrahim, Khaled Mohamed Abdelhameed, Shereen Mamdouh Mohamed Kamal, Eman Mohamed Hussein Khedr, Hassan Ibrahim Mohamed Kotb
Objective. : Hepatocellular carcinoma (HCC) is frequently associated with visceral pain. Transcranial direct current stimulation (tDCS) has been proven to reduce chronic pain; however, its effectiveness in malignant visceral pain is unknown. This study aimed to investigate the effects of tDCS in patients with visceral pain due to HCC. Design. : This is a randomized, sham-controlled, double-blind, prospective study. Forty patients with visceral pain due to HCC were enrolled and randomly assigned into two groups: a real and a sham group; tDCS was applied over the primary motor area (M1) for 10 consecutive days (2 mA, 30 minutes)...
June 12, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28601589/sharpsports-mental-health-awareness-research-project-prevalence-and-risk-factors-of-depressive-symptoms-and-life-stress-in-elite-athletes
#19
Sarah Beable, Mark Fulcher, Arier C Lee, Bruce Hamilton
OBJECTIVES: Our study aims to estimate the prevalence of symptoms of depression and daily life hassles in elite athletes. DESIGN: A cross-sectional prospective epidemiological study design. METHODS: An online anonymous survey was administered during a 2-month period from May to July 2015. Athletes 18 years of age (or older) who were members of the High Performance Sport New Zealand programme were invited to participate. Of 370 potential participants, 187 completed responses were received (51%)...
May 17, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28600189/effect-of-high-dose-simvastatin-on-cognitive-neuropsychiatric-and-health-related-quality-of-life-measures-in-secondary-progressive-multiple-sclerosis-secondary-analyses-from-the-ms-stat-randomised-placebo-controlled-trial
#20
Dennis Chan, Sophie Binks, Jennifer M Nicholas, Chris Frost, M Jorge Cardoso, Sebastien Ourselin, David Wilkie, Richard Nicholas, Jeremy Chataway
BACKGROUND: In the 24-month MS-STAT phase 2 trial, we showed that high-dose simvastatin significantly reduced the annualised rate of whole brain atrophy in patients with secondary progressive multiple sclerosis (SPMS). We now describe the results of the MS-STAT cognitive substudy, in which we investigated the treatment effect on cognitive, neuropsychiatric, and health-related quality-of-life (HRQoL) outcome measures. METHODS: We did a secondary analysis of MS-STAT, a 24-month, double-blind, controlled trial of patients with SPMS done at three neuroscience centres in the UK between Jan 28, 2008, and Nov 4, 2011...
June 6, 2017: Lancet Neurology
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