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https://www.readbyqxmd.com/read/29454165/pituitary-gland-shrinkage-in-bipolar-disorder-the-role-of-gender
#1
Giuseppe Delvecchio, Gian Mario Mandolini, Cinzia Perlini, Marco Barillari, Veronica Marinelli, Mirella Ruggeri, A Carlo Altamura, Marcella Bellani, Paolo Brambilla
BACKGROUND: Hyperactivity of the Hypothalamic-Pituitary-Adrenal Axis (HPAA) has been consistently reported in mood disorders. However, only few studies investigated the Pituitary gland (PG) in Bipolar Disorder (BD) and the results are so far contrasting. Therefore, the aim of this study is to explore the integrity of the PG as well as the role of gender and the impact of clinical measurements on this structure in a sample of BD patients compared to healthy controls (HC). METHODS: 34 BD patients and 41 HC underwent a 1...
February 14, 2018: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29454034/add-on-high-frequency-deep-transcranial-magnetic-stimulation-dtms-to-bilateral-prefrontal-cortex-in-depressive-episodes-of-patients-with-major-depressive-disorder-bipolar-disorder-i-and-major-depressive-with-alcohol-use-disorders
#2
Chiara Rapinesi, Georgios D Kotzalidis, Stefano Ferracuti, Nicoletta Girardi, Abraham Zangen, Gabriele Sani, Ruggero N Raccah, Paolo Girardi, Maurizio Pompili, Antonio Del Casale
BACKGROUND: Dorsolateral prefrontal cortex (DLPFC) is critically involved in mood and alcohol use disorders. OBJECTIVE: We aimed to investigate the safety of intervention with add-on bilateral prefrontal high-frequency deep transcranial magnetic stimulation (dTMS) and between-group differences in treatment response in patients with different types of depressive episodes, including major depressive episodes in the course of major depressive disorder (MDD), bipolar disorder, type I (BD-I), and MDD with alcohol use disorder (MDAUD)...
February 14, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29453037/profile-of-psychiatric-symptoms-in-methamphetamine-users-in-china-greater-risk-of-psychiatric-symptoms-with-a-longer-duration-of-use
#3
Jun Ma, Xin-Jun Sun, Ru-Jia Wang, Tong-Yu Wang, Meng-Fan Su, Mo-Xuan Liu, Su-Xia Li, Ying Han, Shi-Qiu Meng, Ping Wu, Jie Shi, Yan-Ping Bao, Lin Lu
Chronic methamphetamine (MA) use is associated with psychiatric symptoms. This study explored pattern of co-occurring psychiatric symptoms in MA users and their relationship to duration of MA use. A cross-sectional study was conducted among MA users at the Shenzhen Compulsory Drug Detoxification Center from April 2012 to October 2015. The Positive and Negative Syndrome Scale, Hamilton Anxiety Scale, and Beck Depression Inventory were used to assess psychiatric symptoms. Among 1277 MA users, 57.6% participants had any type of psychiatric symptoms including depressive, anxiety and psychotic symptoms...
February 5, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29448310/liquid-chromatography-mass-spectrometry-based-plasma-metabolic-profiling-study-of-escitalopram-in-subjects-with-major-depressive-disorder
#4
Raju Bandu, Hyun Jeong Lee, Hyeong Min Lee, Tae Hyon Ha, Heon-Jeong Lee, Se Joo Kim, Kyooseob Ha, Kwang Pyo Kim
Liquid chromatography-mass spectrometry (LC-MS) method revealed the plasma metabolite profiles in major depressive disorder (MDD) patients treated with escitalopram (ECTP) (n=7). Depression severity was assessed according to the 17-item Hamilton Depression Rating Scale (HAMD-17). Metabolic profiles were derived from MDD subject blood samples collected after ECTP treatment. Blood plasma was separated and processed in order to effectively extract metabolites, which were then analyzed using LC-MS. We identified 19 metabolites and elucidated their structures using LC-tandem mass spectrometry (LC-MS/MS) combined with elemental compositions derived from accurate mass measurements...
February 15, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29448238/parsing-the-heterogeneity-of-depression-an-exploratory-factor-analysis-across-commonly-used-depression-rating-scales
#5
Elizabeth D Ballard, Julia S Yarrington, Cristan A Farmer, Marc S Lener, Bashkim Kadriu, Níall Lally, Deonte Williams, Rodrigo Machado-Vieira, Mark J Niciu, Lawrence Park, Carlos A Zarate
BACKGROUND: Due to the heterogeneity of depressive symptoms-which can include depressed mood, anhedonia, negative cognitive biases, and altered activity levels-researchers often use a combination of depression rating scales to assess symptoms. This study sought to identify unidimensional constructs measured across rating scales for depression and to evaluate these constructs across clinical trials of a rapid-acting antidepressant (ketamine). METHODS: Exploratory factor analysis (EFA) was conducted on baseline ratings from the Beck Depression Inventory (BDI), the Hamilton Depression Rating Scale (HAM-D), the Montgomery-Asberg Depression Rating Scale (MADRS), and the Snaith-Hamilton Pleasure Rating Scale (SHAPS)...
February 5, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29445284/efficacy-acceptability-and-safety-of-adjunctive-aripiprazole-in-treatment-resistant-depression-a-meta-analysis-of-randomized-controlled-trials
#6
Shuxin Luan, Hongquan Wan, Lei Zhang, Hua Zhao
Background: Treatment-resistant depression (TRD) is common and potentially life-threatening in adults, and the benefits and risks of adjunctive aripiprazole in these patients remain controversial. Therefore, we conducted a meta-analysis of randomized controlled trials (RCTs) to assess the efficacy, acceptability, safety, and quality of life of adjunctive aripiprazole in patients with TRD. Methods: RCTs published in PubMed, Web of Science, and Embase were systematically reviewed to evaluate the efficacy and safety profiles of TRD patients who were treated with adjunctive aripiprazole...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29436321/effects-of-selective-serotonin-reuptake-inhibitors-on-rating-scale-assessed-suicidality-in-adults-with-depression
#7
Jakob Näslund, Fredrik Hieronymus, Alexander Lisinski, Staffan Nilsson, Elias Eriksson
BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) have been claimed to elicit or aggravate suicidal ideation. Aims To explore the effect of SSRIs on the suicidality item of the Hamilton Rating Scale for Depression (HRSD). METHOD: We undertook a patient-level mega-analysis of adults with depression participating in industry-sponsored studies of sertraline, paroxetine or citalopram, comparing patients on an SSRI (n = 5681) with those on placebo (n = 2581) with respect to HRSD-rated suicidality...
February 5, 2018: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29432501/venlafaxine-and-sertraline-does-not-affect-the-expression-of-genes-regulating-stress-response-in-female-mdd-patients
#8
Ewa Banach, Aleksandra Szczepankiewicz, Anna Leszczyńska-Rodziewicz, Joanna Pawlak, Monika Dmitrzak-Węglarz, Dorota Zaremba, Joanna Twarowska-Hauser
OBJECTIVES: The aim of this study was to analyze the expression of 3 genes involved in the regulation of HPA axis: GR, HSP90 and FKBP5, in patients with major depressive disorder (MDD) before antidepressant treatment and after 8 weeks of pharmacotherapy. Additionally, we analyzed the level of glucocorticoid receptor isoforms before and after treatment. METHODS: The study included 30 female patients (aged 18-60 years), with major depres- sive disorder diagnosed on the basis of the Structured Clinical Interview for DSM-IV (SCID)...
December 30, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29432299/comparative-metaproteomics-analysis-shows-altered-fecal-microbiota-signatures-in-patients-with-major-depressive-disorder
#9
Zhi Chen, Jie Li, Siwen Gui, Chanjuan Zhou, Jianjun Chen, Chuangchuang Yang, Zicheng Hu, Haiyang Wang, Xiaogang Zhong, Li Zeng, Ke Chen, Pengfei Li, Peng Xie
Major depressive disorder (MDD) is a highly prevalent and debilitating mental illness, which is associated with disorder of gut microbiota. However, few studies focusing on detection of the signatures of bacteria in feces of MDD patients using proteomics approach have been carried out. Here, a comparative metaproteomics analysis on the basis of an isobaric tag for relative and absolute quantification coupled with tandem mass spectrometry was carried out to explore the signature of gut microbiota in patients with MDD...
February 9, 2018: Neuroreport
https://www.readbyqxmd.com/read/29432269/corr-insights%C3%A2-floor-effect-of-promis-depression-cat-associated-with-hasty-completion-in-orthopaedic-surgery-patients
#10
David F Hamilton
No abstract text is available yet for this article.
February 8, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29431126/repetitive-transcranial-magnetic-stimulation-for-depression-after-basal-ganglia-ischaemic-stroke-protocol-for-a-multicentre-randomised-double-blind-placebo-controlled-trial
#11
Ying Tang, Aimin Chen, Shuzhen Zhu, Li Yang, Jiyuan Zhou, Suyue Pan, Min Shao, Lianxu Zhao
INTRODUCTION: Studies suggest that repetitive transcranial magnetic stimulation (rTMS) is effective for the treatment of depression and promotes the repair of white matter. This study aims to assess the effectiveness of rTMS in treating depression after basal ganglia ischaemic stroke and to examine whether such effects are related to restoration of white matter integrity. METHODS AND ANALYSIS: Sixty-six participants will be recruited from Zhujiang Hospital, Nanfang Hospital and Sichuan Bayi Rehabilitation Hospital and randomised in a 1:1 ratio to receive active rTMS treatment or sham rTMS treatment in addition to routine supportive treatments...
February 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29427913/l-carnosine-as-an-add-on-to-risperidone-for-treatment-of-negative-symptoms-in-patients-with-stable-schizophrenia-a-double-blind-randomized-placebo-controlled-trial
#12
Alireza Ghajar, Mohammad-Reza Khoaie-Ardakani, Zahara Shahmoradi, Amir-Reza Alavi, Mohsen Afarideh, Mohammad-Reza Shalbafan, Maryam Ghazizadeh-Hashemi, Shahin Akhondzadeh
Since l-carnosine has shown effectiveness in improvement of cognition in patients with schizophrenia, this 8-week, randomized, double-blind, placebo-controlled pilot study was conducted. Sixty-three patients with chronic schizophrenia, who were clinically stable on a stable dose of risperidone, entered the study. The patients were randomly assigned to l-carnosine (2 gr/day in two divided doses) or placebo for eight weeks. The patients were assessed using the positive and negative syndrome scale (PANSS), extrapyramidal symptom rating scale (ESRS), and Hamilton depression rating scale (HDRS) during the study course...
February 3, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29427911/comparing-characteristics-of-suicide-attempters-with-suicidal-ideation-and-those-without-suicidal-ideation-treated-in-the-emergency-departments-of-general-hospitals-in-china
#13
Shengnan Wei, Haiyan Li, Jinglin Hou, Wei Chen, Shanyong Tan, Xu Chen, Xiaoxia Qin
Suicide attempts are more frequent than suicides, and suicidal ideation has been identified as an important precursor of both attempted and completed suicide. In this study, we compare the characteristics of suicide attempters with suicidal ideation and suicide attempters without suicidal ideation who were treated in the emergency departments of general hospitals in China. We identified 166 people as having suicidal ideation and 73 people who did not have suicidal ideation. The suicide attempters with suicidal ideation were more likely to be more depressed, older, have a lower score on life quality, female, divorced and unemployed, report having religious beliefs, have a suicide attempt history and a psychiatric diagnosis, and intend to reduce pain as motives...
February 3, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29427582/increased-plasma-nesfatin-1-levels-may-be-associated-with-corticosterone-il-6-and-crp-levels-in-patients-with-major-depressive-disorder
#14
Qing-Rong Xia, Jun Liang, Yin Cao, Feng Shan, Yang Liu, Ya-Yun Xu
OBJECTIVES: The aim of the present study was to evaluate the plasma nesfatin-1, corticosterone, and inflammatory cytokine (IL-6, CRP, and TNF-α) concentrations cross-sectionally in patients with major depressive disorder. METHODS: Subjects in the patient group were randomly selected from the Anhui Mental Health Center, and subjects in the control group were selected from healthy volunteers. Healthy control subjects were matched in terms of weight and body mass index...
February 7, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29424758/a-6-year-follow-up-study-of-vagus-nerve-stimulation-effect-on-quality-of-life-in-treatment-resistant-depression-a-pilot-study
#15
François Trottier-Duclos, Véronique Desbeaumes Jodoin, Marie-Pierre Fournier-Gosselin, François Richer, Nathalie Desjardins, Sylvie Tieu, Paul Lespérance
OBJECTIVES: Treatment-resistant depression (TRD) carries a major burden on those affected by this disease and significantly impacts their quality of life (QOL). Vagus nerve stimulation (VNS) has showed promising results on symptoms, but its impact on QOL remains underresearched. This study aims to evaluate the long-term effects of VNS on both QOL and clinical symptoms for TRD patients, through a naturalistic 6-year follow-up. METHOD: Outpatients with confirmed TRD were enrolled to receive VNS...
February 7, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29424401/-association-between-adverse-childhood-experiences-with-depression-in-adults-consulting-in-primary-care
#16
Verónica Vitriol, Alfredo Cancino, Marcelo Leiva-Bianchi, Carlos Serrano, Soledad Ballesteros, Soledad Potthoff, Cristián Cáceres, Marcela Ormazábal, Andrea Asenjo
BACKGROUND: Traumatic experiences during childhood may influence the development of mental disorders during adulthood. AIM: To determine clinical and psychosocial variables that are associated with a higher frequency of adverse childhood experiences (ACE) in patients who consult for depression in Primary Health Care clinics in Chile. MATERIAL AND METHODS: A socio-demographic interview, the mini international neuropsychiatric interview (MINI), a screening for ACE, a questionnaire for partner violence (PV), the Life Experiences Survey (LES) and the Hamilton Rating Scale for Depression (HRDS) were applied to 394 patients with major depression (87% women)...
September 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/29421173/effects-of-chlorpromazine-on-sleep-quality-clinical-and-emotional-measures-among-patients-with-schizophrenia
#17
Qingli Meng, Rongqin Li, Feng Hou, Qiulan Zhang
OBJECTIVES: The present study was aimed to examine the effects of chlorpromazine on sleep quality, clinical and emotional measures in people suffering from schizophrenia. PATIENTS AND METHODS: Twenty-five patients with schizophrenia or schizoaffective disorder were enrolled in this study. Our study included a one-week running-in no-treatment period and two-month experimental period. Patients received chlorpromazine during the experimental period. The baseline and treatment outcome were recorded...
February 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29419640/a-mixed-program-of-psychoeducational-and-psychological-rehabilitation-for-patients-with-bipolar-disorder-in-a-day-hospital-setting
#18
Giovanni Camardese, Massimo Vasale, Lucio DʼAlessandris, Marianna Mazza, Riccardo Serrani, Federico Travagliati, Coco Walstra, Leonardo Zaninotto, Beniamino Leone, Marco Di Nicola, Raffaella Franza, Giuseppe Marano, Lucio Rinaldi, Luigi Janiri
The present study describes a new mixed program of psychoeducational and psychological interventions for bipolar patients, applicable during everyday practice. Thirty-two bipolar patients recruited at a psychiatric day-hospital service have been admitted to a program consisting of 30 meetings and 2 follow-ups at 6 and 12 months. The psychoeducational support determined a general improvement of all included patients. At baseline, patients with residual depression had higher Hamilton Depression Rating Scale (HDRS) scores than euthymic patients (mean score ± SD: 21...
February 6, 2018: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29416577/haptoglobin-phenotype-among-arab-patients-with-mental-disorders
#19
Zaher Armaly, Kamal Farhat, Safa Kinaneh, Joseph Farah
Background: Depression, schizophrenia and panic disorder are common mental disorders in the community and hospitalized patients. These mental disorders negatively affect life quality and even expectancy of life. Haptoglobin (Hp) phenotype (Hp 1-1, 1-2, or 2-2) is associated with risk for cardiovascular diseases, but its association with psychiatric disorders, a growing concern in the modern society, has not been studied thoroughly. The aim of the study was to examine whether Hp phenotype is associated with common mental disorders such as depression, schizophrenia, and panic disorder...
March 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29416341/cognitive-behavioral-group-therapy-versus-psychoeducational-intervention-in-parkinson-s-disease
#20
Isabella Berardelli, Maria Carmela Bloise, Matteo Bologna, Antonella Conte, Maurizio Pompili, Dorian A Lamis, Massimo Pasquini, Giovanni Fabbrini
Objective: The aim of the current study was to evaluate whether cognitive behavioral group therapy has a positive impact on psychiatric, and motor and non-motor symptoms in Parkinson's disease (PD). Methods: We assigned 20 PD patients with a diagnosis of psychiatric disorder to either a 12-week cognitive behavioral therapy (CBT) group or a psychoeducational protocol. For the neurological examination, we administered the Unified Parkinson's Disease Rating Scale and the non-motor symptoms scale...
2018: Neuropsychiatric Disease and Treatment
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