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Hamilton Depression

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https://www.readbyqxmd.com/read/28318797/early-symptom-trajectories-as-predictors-of-treatment-outcome-for-citalopram-versus-placebo
#1
Sigal Zilcha-Mano, Steven P Roose, Patrick J Brown, Bret R Rutherford
OBJECTIVES: The high percentage of failed clinical trials for anti-depressant medications, especially in elderly populations, obscures the fact that some patients may benefit greatly from treatment. Early detection of patients who may benefit most from antidepressant medication may improve treatment decisions. We examined whether depressed patients in a large clinical trial exhibit distinct trajectories of early symptom change that predict differential response to medication or placebo...
February 3, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28315621/scales-for-assessment-of-depression-in-schizophrenia-factor-analysis-of-calgary-depression-rating-scale-and-hamilton-depression-rating-scale
#2
Sandeep Grover, Swapnajeet Sahoo, Devakshi Dua, Subho Chakrabarti, Ajit Avasthi
This study aimed to evaluate the factor structure of Calgary depression rating scale (CDSS) and Hamilton Depression Rating Scale (HDRS) among patients with schizophrenia in acute and remission phase of illness by using exploratory factor analysis. For this, 267 patients with schizophrenia were assessed on CDSS and HDRS. Exploratory factor analysis of CDSS yielded 2 factor models for the whole sample, patients in clinical remission and patients not in clinical remission phase of schizophrenia. Factor analysis of HDRS yielded 3 factor models; however, there was significant difference in the factor structure between those in clinical remission and those not in clinical remission phase of schizophrenia...
March 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28299626/efficacy-and-safety-of-escitalopram-in-treatment-of-severe-depression-in-chinese-population
#3
Tianmei Si, Gang Wang, Fude Yang, Yiru Fang, Maosheng Fang, Jijun Li, Jicheng Dong, Xinhua Shen, Jianmin Zhuo, Qing Rui, Jinan Wang, Hu Cuili
Severe depression accounts for one-third of depressed patients. Increasing severity of depression usually hinders patients from achieving remission. This study evaluated the efficacy and safety of escitalopram in acute-phase treatment of severe major depressive disorder (MDD). A total of 225 participants with severe MDD (Diagnostic and Statistical Manual of Mental Disorders, 4th Edition criteria), with a current depressive episode and Montgomery-Asberg Depression Rating Scale (MADRS) score of ≥30 were enrolled...
March 15, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28298261/efficacy-and-safety-of-agomelatine-10-or-25-mg-day-in-non-depressed-out-patients-with-generalized-anxiety-disorder-a-12-week-double-blind-placebo-controlled-study
#4
Dan J Stein, Antti Ahokas, Marek Jarema, Alla S Avedisova, Livia Vavrusova, Oleg Chaban, Céline Gruget, Valérie Olivier, Françoise Picarel-Blanchot, Christian de Bodinat
Agomelatine is efficacious in reducing symptoms and preventing relapse in placebo-controlled trials in generalised anxiety disorder (GAD). Nevertheless, fixed dose studies of agomelatine in GAD have not been undertaken. To determine the minimally effective optimal dose of agomelatine in GAD, the efficacy of two doses of agomelatine (10 and 25mg/day) was investigated in a 12-week, placebo-controlled, double-blind, international study in patients with a primary diagnosis of GAD. The primary outcome measure was the Hamilton Anxiety scale (HAM-A)...
March 12, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28297589/prospective-longitudinal-study-of-predictors-of-postpartum-onset-depression-in-women-with-a-history-of-major-depressive-disorder
#5
Rita Suri, Zachary N Stowe, Lee S Cohen, D Jeffrey Newport, Vivien K Burt, Ana R Aquino-Elias, Bettina T Knight, Jim Mintz, Lori L Altshuler
OBJECTIVE: Risk factors for postpartum depression in euthymic pregnant women with histories of major depressive disorder (MDD) were evaluated. METHODS: From April 2003 to March 2009, 343 pregnant women with a history of Structured Clinical Interview for DSM-IV (SCID)-diagnosed major depressive disorder were prospectively assessed from the third trimester into the postpartum period using the SCID mood module and 17-item Hamilton Depression Rating Scale (HDRS). Data from 300 subjects who completed at least 2 mood module assessments (1 within 60 days before and the other within 60 days after delivery) were analyzed for predictive associations between variables assessed in the third trimester and the development of a postpartum depression...
March 14, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28295762/psychological-impairments-burden-and-spirituality-in-caregivers-of-terminally-ill-cancer-patients
#6
C Lai, M Luciani, C Di Mario, F Galli, E Morelli, P Ginobbi, P Aceto, L Lombardo
The role of spirituality on the psychological health was mostly investigated through studies conducted in terminally ill patients. However, there are not studies investigating the role of religious and spiritual beliefs on psychological state and on burden dimensions in caregivers. The purpose of this study was to investigate the association between spirituality, burden, and psychological state in caregivers of terminally ill cancer patients. Two hundred caregivers of terminally ill patients with cancer were interviewed using Prolonged Grief Disorder 12 (PG-12), Hamilton Anxiety Rating Scale (HAM-A), Hamilton Depression Scale (HAM-D), Caregiver Burden Inventory (CBI) and System of Belief Inventory (SBI-15R)...
March 14, 2017: European Journal of Cancer Care
https://www.readbyqxmd.com/read/28293470/hypothalamic-pituitary-adrenal-axis-and-depression-symptom-effects-of-an-arginine-vasopressin-type-1b-receptor-antagonist-in-a-one-week-randomized-phase-1b-trial
#7
David A Katz, Charles Locke, Nicholas Greco, Wei Liu, Katherine A Tracy
BACKGROUND: Arginine vasopressin 1B receptor (V1B) antagonists may have utility for the treatment of major depressive disorder (MDD). METHODS: The V1B antagonist ABT-436 (N = 31) or matching placebo (N = 20) was administered to MDD subjects for 7 days. The main study objectives were to assess the safety and hypothalamic-pituitary-adrenal axis (HPA) effects of ABT-436 in MDD subjects. MDD symptoms were assessed using the 17-item Hamilton Depression Rating Scale (HAM-D-17) and the subject-rated Mood and Anxiety Symptom Questionnaire (MASQ)...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28293046/efficacy-of-risperidone-augmentation-with-ondansetron-in-the-treatment-of-negative-and-depressive-symptoms-in-schizophrenia-a-randomized-clinical-trial
#8
Roya Samadi, Susan Soluti, Reza Daneshmand, Shervin Assari, Ali Akhoundpour Manteghi
BACKGROUND: Given the potential role of the 5-hydroxytryptamine-3 receptor in the pathogenesis of schizophrenia, this study was performed to determine whether ondansetron plus risperidone could reduce the negative and depressive symptoms in patients with treatment-resistant schizophrenia. METHODS: In a double-blinded, placebo-controlled, randomized trial (IRCT registration # 201112125280N7), in 2012-2013 in Mashhad, Iran, 38 patients with treatment-resistant schizophrenia received risperidone either combined with a fixed dose (4-8 mg/d) of ondansetron (n=18) or with a placebo (n=20) for 12 weeks...
January 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28292331/the-ghent-psychotherapy-study-gps-on-the-differential-efficacy-of-supportive-expressive-and-cognitive-behavioral-interventions-in-dependent-and-self-critical-depressive-patients-study-protocol-for-a-randomized-controlled-trial
#9
Reitske Meganck, Mattias Desmet, Claudi Bockting, Ruth Inslegers, Femke Truijens, Melissa De Smet, Rosa De Geest, Kimberly Van Nieuwenhove, Vicky Hennissen, Goedele Hermans, Tom Loeys, Ufuoma Angelica Norman, Chris Baeken, Stijn Vanheule
BACKGROUND: Major depressive disorder is a leading cause of disease burden worldwide, indicating the importance of effective therapies. Outcome studies have shown overall efficacy of different types of psychotherapy across groups, yet large variability within groups. Although patient characteristics are considered crucial in understanding outcome, they have received limited research attention. This trial aims at investigating the interaction between therapeutic approach (pre-structured versus explorative) and the personality style of patients (dependent versus self-critical), which is considered a core underlying dimension of depressive pathology...
March 14, 2017: Trials
https://www.readbyqxmd.com/read/28291973/activity-of-the-hypothalamic-pituitary-adrenal-axis-and-inflammatory-mediators-in-major-depressive-disorder-with-or-without-metabolic-syndrome
#10
Marko Martinac, Dragan Babić, Milenko Bevanda, Ivan Vasilj, Danijela Bevanda Glibo, Dalibor Karlović, Miro Jakovljević
BACKGROUND: The aim of the present study was to explore the differences in serum CRP, IL-6, TNF-α, ACTH and cortisol among patients with major depressive disorder with or without metabolic syndrome (MS) compared to a healthy control group. SUBJECTS AND METHODS: The MDD study group consisted of 80 patients (mean age of 50.03±9.55 years). The control group was recruited from the hospital personnel and it consisted of 40 examinees (mean age of 47.20±7.99 years)...
March 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28291972/efficacy-safety-and-tolerability-of-augmentative-rtms-in-treatment-of-major-depressive-disorder-mdd-a-prospective-cohort-study-in-croatia
#11
Igor Filipcic, Zeljko Milovac, Strahimir Sucic, Tomislav Gajsak, Ivona Simunovic Filipcic, Ena Ivezic, Vjekoslav Aljinovic, Ivana Orgulan, Sandra Zecevic Penic, Zarko Bajic
BACKGROUND: An increasing body of research suggest that repetitive Transcranial Magnetic Stimulation (rTMS) is effective and safe treatment option for patients with major depressive disorder (MDD). The Psychiatric Hospital "Sveti Ivan" has the first TMS laboratory with rTMS and deep TMS (dTMS) in Croatia. The objective of this study was to assess the efficacy, safety and tolerability of augmentative rTMS treatment vs standard treatment in Croatian patients with major depressive disorder (MDD)...
March 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28291238/polymorphisms-of-5-htt-lpr-and-gn%C3%AE-3-825c-t-and-response-to-antidepressant-treatment-in-functional-dyspepsia-a-study-from-the-functional-dyspepsia-treatment-trial
#12
Yuri A Saito, G Richard Locke, Ann E Almazar, Ernest P Bouras, Colin W Howden, Brian E Lacy, John K DiBaise, Charlene M Prather, Bincy P Abraham, Hashem B El-Serag, Paul Moayyedi, Linda M Herrick, Lawrence A Szarka, Michael Camilleri, Frank A Hamilton, Cathy D Schleck, Katherine E Tilkes, Alan R Zinsmeister, Nicholas J Talley
OBJECTIVES: The Functional Dyspepsia Treatment Trial reported that amitriptyline (AMI) was associated with adequate relief of functional dyspepsia (FD) symptoms, but the pharmacogenetics of antidepressant response in FD are not known. GNβ3 825C>T CC genotype has been previously linked to FD and TT genotype to antidepressant response in depression. The ss genotype of the 5-HTT LPR variant of the serotonin transporter gene (SLC6A4) has been linked to selective serotonin reuptake inhibitor (SSRI) response...
March 14, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28287202/-inflammatory-bowel-disease-and-quality-of-life-psychopathological-variants
#13
Vincenzo Prisco, Teresa Iannaccone
INTRODUCTION: Purpose of the study was to analyze the quality of life and psychiatric symptomatology in patients suffering from Inflammatory Bowel Diseases. METHODS: In this study were enrolled 108 patients: 67 cases (Ulcerative Colitis in 39 patients, Crohn's Disease in 28 cases) and 41 controls (patients suffering from Irritable Bowel Syndrome). Patients were subjected to Self-Report Symptom Inventory-Revised (SCL-90-R) to analyze general psychiatric symptomatology; Hamilton Depression Rating Scale (HAM-D) to analyze depressive symptomatology; Short Form-36 (SF-36) to evaluate the quality of life...
February 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28287201/-depression-anxiety-and-anger-in-patients-with-type-1-diabetes-mellitus
#14
Maria Rosaria Anna Muscatello, Giulia Maria Troili, Gianluca Pandolfo, Carmela Mento, Giuseppa Gallo, Giulia Lanza, Basilio Pintaudi, Giacoma Di Vieste, Antonino Di Benedetto, Rocco Antonio Zoccali, Antonio Bruno
INTRODUCTION: The aim of this study is to evaluate the influence of negative emotions such as depression, anxiety and anger on clinical expression of type 1 diabetes, also assessing possible gender differences. MATERIALS AND METHODS: 75 subjects with type 1 diabetes mellitus afferent to Diabetology Unit of the University Hospital in Messina underwent the following psychodiagnostic tests: Hamilton Rating Scale For Depression (HDRS), State-Trait Anxiety Inventory form Y (STAI-Y), State-Trait Anger Expression Inventory-2 (STAXI-2)...
February 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28286473/neurocognitive-predictors-of-response-in-treatment-resistant-depression-to-subcallosal-cingulate-gyrus-deep-brain-stimulation
#15
Shane J McInerney, Heather E McNeely, Joseph Geraci, Peter Giacobbe, Sakina J Rizvi, Amanda K Ceniti, Anna Cyriac, Helen S Mayberg, Andres M Lozano, Sidney H Kennedy
Background: Deep brain stimulation (DBS) is a neurosurgical intervention with demonstrated effectiveness for treatment resistant depression (TRD), but longitudinal studies on the stability of cognitive parameters following treatment are limited. The objectives of this study are to (i) identify baseline cognitive predictors of treatment response to subcallosal cingulate gyrus (SCG) DBS for unipolar TRD and (ii) compare neurocognitive performance prior to and 12 months after DBS implantation. Methods: Twenty unipolar TRD patients received SCG DBS for 12 months...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28285255/relationships-between-circadian-measures-depression-and-response-to-antidepressant-treatment-a-preliminary-investigation
#16
Leslie M Swanson, Helen J Burgess, Edward D Huntley, Holli Bertram, Ann Mooney, Jennifer Zollars, Richard Dopp, Robert Hoffmann, Roseanne Armitage, J Todd Arnedt
Few studies have examined relationships between circadian rhythms and unipolar major depressive disorder. Further, no study to date has examined circadian markers as predictors of response to depression treatment. In the present study, we examined associations between circadian timing and its alignment with sleep and depression severity in 30 adults with major depressive disorder who completed a randomized controlled trial of two weeks of time in bed (TIB) restriction administered adjunctive to fluoxetine, with a focus on sex differences...
March 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28280987/vestibular-migraine-patients-are-more-anxious-than-migraine-patients-without-vestibular-symptoms
#17
Özge Kutay, Gülden Akdal, Pembe Keskinoğlu, Birgül Dönmez Balcı, Tunç Alkın
The link between vertigo and anxiety is well known. The aim of this study is to compare anxiety disorders in 3 groups: patients with vestibular migraine (VM), patients with migraine but without vertigo (MO) and healthy controls (HC).We performed cross-sectional analysis of following tests: (a) Hamilton Anxiety Rating Scale (HAMA); (b) State-Trait Anxiety Inventory (STAI-X1 and STAI-X2); (c) Beck Depression Inventory (BDI); (d) Panic-Agoraphobic Scale and (e) Penn State Worry Questionnaire (PSWQ). ANOVA, Kruskal-Wallis and Chi-square tests were used for comparisons and least significant difference was used for further post-hoc analysis...
March 9, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28280343/efficacy-and-safety-of-olanzapine-fluoxetine-combination-in-the-treatment-of-treatment-resistant-depression-a-meta-analysis-of-randomized-controlled-trials
#18
Shuxin Luan, Hongquan Wan, Shijun Wang, He Li, Baogang Zhang
BACKGROUND: Whether olanzapine/fluoxetine combination (OFC) is superior to olanzapine or fluoxetine monotherapy in patients with treatment-resistant depression (TRD) remains controversial. Thus, we conducted this meta-analysis of randomized controlled trials (RCTs) to compare the efficacy and safety of OFC with olanzapine or fluoxetine monotherapy for patients with TRD. MATERIALS AND METHODS: RCTs published in PubMed, Embase, Web of Science, and the ClinicalTrials...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28278485/dynamic-multimodal-measurement-of-depression-severity-using-deep-autoencoding
#19
Hamdi Dibeklioglu, Zakia Hammal, Jeffrey F Cohn
Depression is one of the most common psychiatric disorders worldwide, with over 350 million people affected. Current methods to screen for and assess depression depend almost entirely on clinical interviews and self-report scales. While useful, such measures lack objective, systematic, and efficient ways of incorporating behavioral observations that are strong indicators of depression presence and severity. Using dynamics of facial and head movement and vocalization, we trained classifiers to detect three levels of depression severity...
March 2, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28276950/evaluation-of-the-effect-of-spiritual-care-on-patients-with-generalized-anxiety-and-depression-a-randomized-controlled-study
#20
A Sankhe, K Dalal, D Save, P Sarve
The present study was conducted to assess the effect of spiritual care in patients with depression, anxiety or both in a randomized controlled design. The participants were randomized either to receive spiritual care or not and Hamilton anxiety rating scale-A (HAM-A), Hamilton depression rating scale-D (HAM-D), WHO-quality of life-Brief (WHOQOL-BREF) and Functional assessment of chronic illness therapy - Spiritual well-being (FACIT-Sp) were assessed before therapy and two follow-ups at 3 and 6 week. However, with regard to the spiritual care therapy group, statistically significant differences were observed in both HAM-A and HAM-D scales between the baseline and visit 2 (p < 0...
February 8, 2017: Psychology, Health & Medicine
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