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https://www.readbyqxmd.com/read/29783015/extracts-of-compound-muniziqi-granule-suppressed-uterus-contraction-and-ameliorated-oxytocin-inducedprimary-dysmenorrhea
#1
Yue Wei, Tingyun Ma, Hanxue Wang, Jianguo Xing, Yuwen Wang, Zhengyi Gu, Dandan Mu, Qiang Yin, Xuemei Cheng, Changhong Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Compound Muniziqi granule (CMG) is usually used as a traditional Uighur medicine to treat acne, chloasma, skin inflammation, primary dysmenorrhea (PDM), and menopausal syndrome. However, there are no sufficient data to support the clinic uses of CMG in PDM. AIM OF THE STUDY: This work aims to examine the effect of CMG as a treatment for PDM and reveal its possible therapeutic mechanism. MATERIALS AND METHODS: In vivo and in vitro mouse PDM models were utilized in this study...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29780819/a-comprehensive-review-of-the-pharmacologic-management-of-uterine-leiomyoma
#2
REVIEW
Terrence D Lewis, Minnie Malik, Joy Britten, Angelo Macapagal San Pablo, William H Catherino
Uterine leiomyomata are the most common benign tumors of the gynecologic tract impacting up to 80% of women by 50 years of age. It is well established that these tumors are the leading cause for hysterectomy with an estimated total financial burden greater than $30 billion per year in the United States. However, for the woman who desires future fertility or is a poor surgical candidate, definitive management with hysterectomy is not an optimal management plan. Typical gynecologic symptoms of leiomyoma include infertility, abnormal uterine bleeding (AUB)/heavy menstrual bleeding (HMB) and/or intermenstrual bleeding (IMB) with resulting iron-deficiency anemia, pelvic pressure and pain, urinary incontinence, and dysmenorrhea...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29780815/endometriosis-malignant-transformation-epigenetics-as-a-probable-mechanism-in-ovarian-tumorigenesis
#3
REVIEW
Jiaxing He, Weiqin Chang, Chunyang Feng, Manhua Cui, Tianmin Xu
Endometriosis, defined as the presence of ectopic endometrial glands and stroma outside the uterine cavity, is a chronic, hormone-dependent gynecologic disease affecting millions of women across the world, with symptoms including chronic pelvic pain, dysmenorrhea, dyspareunia, dysuria, and subfertility. In addition, there is well-established evidence that, although endometriosis is considered benign, it is associated with an increased risk of malignant transformation, with the involvement of various mechanisms of development...
2018: International Journal of Genomics
https://www.readbyqxmd.com/read/29777846/an-academic-tertiary-referral-center-s-experience-with-a-vascular-surgery-based-uterine-artery-embolization-program
#4
Naiem Nassiri, Adrian Balica, Nolan C Cirillo-Penn, Dustin Tyler Crystal, Gloria A Bachmann
OBJECTIVE: Despite growing endovascular experience within the vascular surgery community, some catheter-based interventions - such as uterine artery embolization (UAE) - remain outside the clinical scope of most vascular surgeons, owing in part to established referral patterns and limited awareness among referring colleagues. We present our experience with a vascular surgery-based, multidisciplinary UAE program at an academic tertiary referral center. METHODS: In a collaborative effort between vascular surgery and gynecology, a Pelvic Vascular Disease Program has been established to provide palliative, prophylactic, and therapeutic embolizations including, but not limited to, UAE...
May 16, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29772407/total-laparoscopic-hysterectomy-for-endometriosis-and-an-arteriovenous-malformation
#5
Emilie Schwartz, Emilie Faller, Chérif Youssef Akladios, Michel Greget, Catherine Roy, Arnaud Wattiez
STUDY OBJECTIVE: Demonstrate a laparoscopic management of an arteriovenous malformation in a patient with deep pelvic endometriosis DESIGN: A step-by-step explanation of the surgery using video (instructive video). SETTING: Hautepierre Universitary Hospital of Strasbourg in France INTERVENTION: We describe the case of a 37 years old patient presenting deep pelvic endometriosis and an uterine arteriovenous malformation. It was during a tubal ligation in 2015, that the deep pelvic endometriosis was diagnosed...
May 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29763921/peptidomic-analysis-of-endometrial-tissue-from-patients-with-ovarian-endometriosis
#6
Yunping Xue, Pengfei Xu, Sujuan Xu, Kai Xue, Lingling Xu, Jie Chen, Juan Xu, Xiaoyan Shi, Qian Li, Lin Gu
BACKGROUND/AIMS: Ovarian endometriosis (OvE) is ovarian cyst that is lined with endometrial tissue. They are found in 17-44% of women with endometriosis. Their clinical manifestations include pelvic pain, dysmenorrhea, dyspareunia, and infertility. Although the incidence of OvE has increased yearly, the exact pathogenesis of OvE is still unclear. We used peptidomics, an emerging branch of proteomics, to identify differentially expressed peptides in order to determine the possible roles of these peptides in the pathogenesis of OvE...
May 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29762822/linc-ror-promotes-endometrial-cell-proliferation-by-activating-the-pi3k-akt-pathway
#7
X-Y Xu, J Zhang, Y-H Qi, M Kong, S-A Liu, J-J Hu
OBJECTIVE: To observe the expressions of Linc-ROR and proteins in the PI3K-Akt pathway in an ectopic lesion of adenomyosis. PATIENTS AND METHODS: The expression of Linc-ROR in the ectopic endometrium, eutopic endometrium, and normal endometrium of adenomyosis was detected by qRT-PCR. Western blot was used to detect the protein expressions of PI3K-Akt in endometriosis and lesion endometriosis. Cell counting kit-8 (CCK-8) assay was utilized to detect cell proliferative activity...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29747214/intestinal-perforation-due-to-deep-infiltrating-endometriosis-during-pregnancy-case-report
#8
Márcia Mendonça Carneiro, Luciana Maria Pyramo Costa, Maria Das Graças Torres, Patrícia Salomé Gouvea, Ivete de Ávila
We report the case of a 33 year-old woman who complained of severe dysmenorrhea since menarche. From 2003 to 2009, she underwent 4 laparoscopies for the treatment of pain associated with endometriosis. After all four interventions, the pain recurred despite the use of gonadotropin-releasing hormone (GnRH) analogues and the insertion of a levonorgestrel intrauterine system (LNG-IUS). Finally, a colonoscopy performed in 2010 revealed rectosigmoid stenosis probably due to extrinsic compression. The patient was advised to get pregnant before treating the intestinal lesion...
April 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29745745/mental-health-and-primary-dysmenorrhea-a-systematic-review
#9
Zahra Bajalan, Farnoosh Moafi, Mohammad MoradiBaglooei, Zainab Alimoradi
Several factors including demographic, reproductive, lifestyle, psychological and social factors can affect incidence and severity of primary dysmenorrhea. This study aimed to systematically review the psychological risk factors associated with primary dysmenorrhea. Embase, ISI web of knowledge, ProQuest, Science Direct, Scopus and PubMed central were searched using keywords related to risk factors and primary dysmenorrhea. Observational studies, published in English after 2000, focusing solely on psychological factors affecting primary dysmenorrhea were included...
May 10, 2018: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29741912/therapeutic-effects-of-standardized-formulation-of-stachys-lavandulifolia-vahl-on-primary-dysmenorrhea-a-randomized-double-blind-crossover-placebo-controlled-pilot-study
#10
Faezeh Monji, Farshad Hashemian, Mohammad-Hossein Salehi Surmaghi, Fatemeh Mohammadyari, Saeid Ghiyaei, Alireza Soltanmohammadi
OBJECTIVES: In Iranian folklore medicine, boiled extract of Stachys lavandulifolia Vahl is reputed to have therapeutic effects in painful disorders. This study evaluated the efficacy of the standardized formulation of S. lavandulifolia Vahl in reducing pain in primary dysmenorrhea, which is known to be a common disorder with significant impact on quality of life. DESIGN: A randomized, double blind, crossover, placebo-controlled pilot study. SETTINGS/LOCATION: Bu-Ali Hospital affiliated with Tehran Medical Branch, Islamic Azad University...
May 9, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/29737300/effect-of-laparoscopy-combined-with-mifepristone-in-the-treatment-of-endometriosis-and-drug-reaction-analysis
#11
Jing Li, Huilin Yang, Jie Song
Endometriosis is a common benign disease of Gynecology, which often causes symptoms of dysmenorrhea, pelvic pain and infertility. In this paper, we analyzed the effect of laparoscopy combined with mifepristone in the treatment of endometriosis. By observing the clinical efficacy and side effects of small dose mifepristone, we explored the feasibility of small dose mifepristone in the treatment of recurrent endometriosis. The results showed that the clinical symptoms of small dose mifepristone group and danazol group were improved to varying degrees...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29735467/effect-of-laparoscopy-combined-with-mifepristone-in-the-treatment-of-endometriosis-and-drug-reaction-analysis
#12
Jing Li, Huilin Yang, Jie Song
Endometriosis is a common benign disease of Gynecology, which often causes symptoms of dysmenorrhea, pelvic pain and infertility. In this paper, we analyzed the effect of laparoscopy combined with mifepristone in the treatment of endometriosis. By observing the clinical efficacy and side effects of small dose mifepristone, we explored the feasibility of small dose mifepristone in the treatment of recurrent endometriosis. The results showed that the clinical symptoms of small dose mifepristone group and danazol group were improved to varying degrees...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29733841/abdominal-skeletal-muscle-activity-precedes-spontaneous-menstrual-cramping-pain-in-primary-dysmenorrhea
#13
Folabomi A Oladosu, Frank F Tu, Saaniya Farhan, Ellen F Garrison, Nicole D Steiner, Genevieve E Roth, Kevin M Hellman
BACKGROUND: Dysmenorrhea is a pervasive pain condition that affects 20-50% of reproductive-aged women. Distension of a visceral organ, such as the uterus, could elicit a viscero-motor reflex resulting in involuntary skeletal muscle activity and referred pain. Although referred abdominal pain mechanisms can contribute to visceral pain, the role of abdominal muscle activity has not yet been investigated within the context of menstrual pain. OBJECTIVE: The goal of this study is to determine if involuntary abdominal muscle activity precedes spontaneous episodes of menstrual cramping pain in dysmenorrheic women and if naproxen administration affects abdominal muscle activity...
May 4, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29729556/effects-of-aromatherapy-on-dysmenorrhea-a-systematic-review-and-meta-analysis
#14
Ji-Ah Song, Mi-Kyoung Lee, Eunsil Min, Mi-Eun Kim, Geraldine Fike, Myung-Haeng Hur
OBJECTIVE: Menstrual pain is not a disease, but it is a problem that periodically makes women uncomfortable during menstrual cycles. There has been a continuing effort to alleviate menstrual cramps in the medical field. Aromatherapy, one of the alternative complementary therapies, has been used as a way to alleviate menstrual cramps, but there is still little evidence of how to use it. Therefore, in this study, we tried to find and provide the evidence of relieving effects of menstrual cramps...
February 2, 2018: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29725285/ovarian-endometriosis-risk-factor-analysis-and-prediction-of-malignant-transformation
#15
YanNa Zhou, Ke-Qin Hua
Introduction: For the prediction of endometriosis associated ovarian carcinoma (EAOC), the risk factors for malignant ovarian endometriosis (MOE) were explored. Material and methods: A group of 104 EAOC patients was compared with a group of 104 ovarian endometrial cyst patients. Using single and multivariate risk analysis of EAOC by calculating the area under the curve (AUC) of receiver-operator characteristics (ROC) curves, risks of MOE transformation were calculated for various burdens of risk factors...
March 2018: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/29708902/the-case-against-endometrial-ablation-for-treatment-of-heavy-menstrual-bleeding
#16
Michelle Louie, Kelly Wright, Matthew Siedhoff
PURPOSE OF REVIEW: Endometrial ablation is a common treatment for heavy menstrual bleeding, but serious limitations and long-term complications exist. Our purpose is to summarize the use of endometrial ablation devices, potential short-term and long-term complications, cost effectiveness, and quality of life in relation to alternative treatments. RECENT FINDINGS: There is insufficient evidence to strongly recommend one endometrial ablation device over another. Providers should consider and discuss with their patients, complications including risk of future pregnancy, endometrial cancer, and hysterectomy for continued bleeding or pain...
April 27, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29708827/big-data-and-dysmenorrhea-what-questions-do-women-and-men-ask-about-menstrual-pain
#17
Chen X Chen, Doyle Groves, Wendy R Miller, Janet S Carpenter
BACKGROUND: Menstrual pain is highly prevalent among women of reproductive age. As the general public increasingly obtains health information online, Big Data from online platforms provide novel sources to understand the public's perspectives and information needs about menstrual pain. The study's purpose was to describe salient queries about dysmenorrhea using Big Data from a question and answer platform. MATERIALS AND METHODS: We performed text-mining of 1.9 billion queries from ChaCha, a United States-based question and answer platform...
April 30, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29704486/identification-of-experimental-bladder-sensitivity-among-dysmenorrhea-sufferers
#18
Kevin M Hellman, Avisek Datta, Nicole D Steiner, Julia N Kane Morlock, Ellen F Garrison, Daniel J Clauw, Frank F Tu
BACKGROUND: Dysmenorrhea is a common risk factor for chronic pain conditions including bladder pain syndrome. Few studies have formally evaluated asymptomatic bladder pain sensitivity in dysmenorrhea, and whether this largely reflects excess pelvic symptom reporting due to comorbid psychological dysfunction. OBJECTIVE: We sought to determine whether bladder hypersensitivity is more common among women reporting moderate or greater dysmenorrhea, without chronic pain elsewhere, after accounting for anxiety and depression...
April 25, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29701050/-clinical-application-of-categorization-by-analogy-in-acupuncture-for-pain-syndromes
#19
Xiaojun Chen
The"categorization by analogy"is one of the most primitive thinking methods for ancient people to explore the world, which has exerted far-reaching impact on the origin and development of TCM. With examples of Sanjian (LI 3) for neck pain, Chize (LU 5) for low back pain and Chengshan (BL 57) for dysmenorrhea, the clinical application of"categorization by analogy"in acupuncture for pain syndromes was discussed, hoping more acupuncturists will pay attention to the guiding role of"categorization by analogy"in acupuncture clinical treatment...
March 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29699636/conservative-surgery-of-diffuse-adenomyosis-with-toua-single-surgeon-experience-of-one-hundred-sixteen-cases-and-report-of-fertility-outcomes
#20
Jae-Young Kwack, Yong-Soon Kwon
The aim of this study is to evaluate the clinical outcomes of conservative adenomyomectomy with TOUA for diffuse uterine adenomyosis and to determine the feasibility and safety. One hundred and sixteen patients with symptomatic diffuse uterine adenomyosis underwent adenomyomectomy with TOUA by a single surgeon at Ulsan University Hospital between May 2011 and March 2016. Surgical outcomes included operative time, intraoperative injury and operative blood loss. We assessed the degree of improvement in dysmenorrhea and menorrhagia at the 7-month follow-up visit after the operation...
May 2018: Kaohsiung Journal of Medical Sciences
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