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https://www.readbyqxmd.com/read/29166605/l-type-voltage-gated-ca-2-channels-regulate-synaptic-activity-triggered-recycling-endosome-fusion-in-neuronal-dendrites
#1
Brian G Hiester, Ashley M Bourke, Brooke L Sinnen, Sarah G Cook, Emily S Gibson, Katharine R Smith, Matthew J Kennedy
The repertoire and abundance of proteins displayed on the surface of neuronal dendrites are tuned by regulated fusion of recycling endosomes (REs) with the dendritic plasma membrane. While this process is critical for neuronal function and plasticity, how synaptic activity drives RE fusion remains unexplored. We demonstrate a multistep fusion mechanism that requires Ca(2+) from distinct sources. NMDA receptor Ca(2+) initiates RE fusion with the plasma membrane, while L-type voltage-gated Ca(2+) channels (L-VGCCs) regulate whether fused REs collapse into the membrane or reform without transferring their cargo to the cell surface...
November 21, 2017: Cell Reports
https://www.readbyqxmd.com/read/29165328/transformation-of-a-thermostable-g-quadruplex-structure-into-dna-duplex-driven-by-reverse-gyrase
#2
Dawei Li, Qiang Wang, Yun Liu, Kun Liu, Qiang Zhuge, Bei Lv
Reverse gyrase is a topoisomerase that can introduce positive supercoils to its substrate DNA. It is demonstrated in our studies that a highly thermal stable G-quadruplex structure in a mini-plasmid DNA was transformed into its duplex conformation after a treatment with reverse gyrase. The structural difference of the topoisomers were verified and analyzed by gel electrophoresis, atomic force microscopy examination, and endonuclease digestion assays. All evidence suggested that the overwinding structure of positive supercoil could provide a driven force to disintegrate G-quadruplex and reform duplex...
November 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29165160/a-review-of-vietnam-s-healthcare-reform-through-the-direction-of-healthcare-activities-doha
#3
REVIEW
Kyoko Takashima, Koji Wada, Ton Thanh Tra, Derek R Smith
OBJECTIVE: This article provides a comprehensive review of the healthcare reform process driven by the Vietnamese Ministry of Health's Direction of Healthcare Activities (DOHA) scheme. METHODS: We reviewed policy documents relating to DOHA, along with historical literature and background information describing its formation. RESULTS: DOHA (Chỉ đạo tuyến in Vietnamese) literally means guidance line or level in English. It requires healthcare facilities at higher government administration levels to support those at lower levels (the four levels being central, provincial, district, and commune), to help lower level hospitals to provide medical services for local communities in primary care settings and reduce the number of patients in higher level (central and provincial) hospitals...
October 30, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29164544/-construction-and-application-of-innovative-education-technology-strategies-in-nursing
#4
Li-Fen Chao, Hsiang-Ping Huang, Lee-Fen Ni, Chia-Lan Tsai, Tsuey-Yuan Huang
The evolution of information and communication technologies has deeply impacted education reform, promoted the development of digital-learning models, and stimulated the development of diverse nursing education strategies in order to better fulfill needs and expand in new directions. The present paper introduces the intelligent-learning resources that are available for basic medical science education, problem-based learning, nursing scenario-based learning, objective structured clinical examinations, and other similar activities in the Department of Nursing at Chang Gung University of Science and Technology...
December 2017: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29164093/application-of-the-intervention-mapping-framework-to-develop-an-integrated-twenty-first-century-core-curriculum-part-three-curriculum-implementation-and-evaluation
#5
Jaime A Corvin, Rita DeBate, Kate Wolfe-Quintero, Donna J Petersen
Public health professionals have been challenged to radically reform public health training to meet evolving demands of twenty-first century public health. Such a transformation requires a systems thinking approach with an interdisciplinary focus on problem solving, leadership, management and teamwork, technology and information, budgeting and finance, and communication. This article presents processes for implementing and evaluating a revised public health curriculum and outlines lessons learned from this initiative...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29163903/hydrogen-generation-from-methanol-at-near-room-temperature
#6
Yangbin Shen, Yulu Zhan, Shuping Li, Fandi Ning, Ying Du, Yunjie Huang, Ting He, Xiaochun Zhou
As a promising hydrogen storage medium methanol has many advantages such as a high hydrogen content (12.5 wt%) and low-cost. However, conventional methanol-water reforming methods usually require a high temperature (>200 °C). In this research, we successfully designed an effective strategy to fully convert methanol to hydrogen for at least 1900 min (∼32 h) at near-room temperature. The strategy involves two main procedures, which are CH3OH → HCOOH → H2 and CH3OH → NADH → H2. HCOOH and the reduced form of nicotinamide adenine dinucleotide (NADH) are simultaneously produced through the dehydrogenation of methanol by the cooperation of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH)...
November 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29162326/identifying-perceptions-of-academic-reform-in-pharmacy-using-a-four-frame-organizational-change-model
#7
Dalia Bajis, Betty Chaar, Iman A Basheti, Rebekah Moles
BACKGROUND: In an ever-changing environment, pharmacy education is in the race to catch up and excel to produce competent pharmacists. Examining academic institutions, including schools of pharmacy, their internal systems and framework, it seems appropriate to view these institutions using multiple lenses. Bolman and Deal conceptualized a method to examine organizations using four constructs (structural, human resource, political, and symbolic). The Eastern Mediterranean Region (EMR), with deep-rooted pharmacy education and practice was the setting for this research...
November 10, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/29161393/quality-safety-and-outcomes-in-anaesthesia-what-s-to-be-done-an-international-perspective
#8
C J Peden, M Campbell, G Aggarwal
This article reviews of some of the key topics and challenges in quality, safety, and the measurement and improvement of outcomes in anaesthesia. The topics were selected based on the perspective of an individual with quality and safety expertise and recent experience of the specialty in both the UK and USA. The review does not seek to be exhaustive or systematic, but to highlight current areas of concern and potential solutions. The topic is subdivided into sections where the system of health care is viewed from different levels...
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29160985/emergency-medicine-stakeholders-voice-priorities-for-healthcare-reform-urge-individual-clinicians-to-get-involved
#9
Rebecca Parker, Karen Wiley
No abstract text is available yet for this article.
April 2017: ED Management: the Monthly Update on Emergency Department Management
https://www.readbyqxmd.com/read/29159768/the-impact-of-dealing-with-the-late-effects-of-national-socialist-terror-on-west-german-psychiatric-care
#10
Felicitas Söhner, Gerhard Baader
Health damages and the late effects of NS trauma were largely ignored in German-speaking countries. This paper describes how dealing with the late effects of Nazi terror influenced post-war psychiatry in West Germany and thus the development of the psychiatric reform. As part of a greater overview study of the impulses and framework conditions of the reform-orientated development of post-war psychiatry in West Germany, this analysis is based on a thorough literary and documentary analysis. The sources show that publications by Helmut Paul and Herberg [81] as well as Baeyer et al...
November 21, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/29159217/data-on-strategically-located-land-and-spatially-integrated-urban-human-settlements-in-south-africa
#11
Walter Musakwa
In developing countries like South Africa processed geographic information systems (GIS) data on land suitability, is often not available for land use management. Data in this article is based on a published article "The strategically located land index support system for humans settlements land reform in South Africa" (Musakwa et al., 2017) [1]. This article utilities data from Musakwa et al. (2017) [1] and it goes on a step further by presenting the top 25th percentile of areas in the country that are strategically located and suited to develop spatially integrated human settlements...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/29158421/urban-rural-comparisons-in-hospital-admission-treatments-and-outcomes-for-st-segment-elevation-myocardial-infarction-in-china-from-2001-to-2011-a-retrospective-analysis-from-the-china-peace-study-patient-centered-evaluative-assessment-of-cardiac-events
#12
Xi Li, Karthik Murugiah, Jing Li, Frederick A Masoudi, Paul S Chan, Shuang Hu, John A Spertus, Yongfei Wang, Nicholas S Downing, Harlan M Krumholz, Lixin Jiang
BACKGROUND: In response to urban-rural disparities in healthcare resources, China recently launched a healthcare reform with a focus on improving rural care during the past decade. However, nationally representative studies comparing medical care and patient outcomes between urban and rural areas in China during this period are not available. METHODS AND RESULTS: We created a nationally representative sample of patients in China admitted for ST-segment-elevation myocardial infarction in 2001, 2006, and 2011, using a 2-stage random sampling design in 2 urban and 3 rural strata...
November 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/29157566/is-health-care-payment-reform-impacting-nurses-work-settings-roles-and-education-preparation
#13
Mary Val Palumbo, Betty Rambur, Vicki Hart
This study explores nurses' work settings and educational preparation in the five years before passage of the Affordable Care Act (ACA) and five years after ACA passage, with the aim of identifying areas for nurse educators' attention. The study setting was one small state undergoing rapid transition away from fee-for-service service and thus provided the ideal laboratory to assess the impact of health reform on the nursing workforce. A secondary analysis of data gathered during relicensure compared the nursing workforce at an interval of one decade, with surveys in 2005 (n=4075; 65% response rate) and in 2015 (n=6723; 97% response rate)...
November 2017: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
https://www.readbyqxmd.com/read/29157515/legal-capacity-of-persons-with-disabilities-in-ethiopia-the-need-to-reform-existing-legal-frameworks
#14
Mohammed Hamza Marishet
The Convention on the Rights of Persons with Disabilities (CRPD) prohibited deprivation legal capacity of persons with disability based on assessment of mental capacity. The assertion is that, persons with disabilities shall exercise their legal capacity in all aspects of life without any restrictions that are based on mental incapacity (such as, unsoundness of mind, deficit in mental capacity, dotage, etc. This approach signifies a shift from substituted decision making, where another person act on behalf of persons with mental disabilities, to supported decision making where the person with mental disability is assisted in decision making...
November 2017: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/29157512/the-closing-of-forensic-psychiatric-hospitals-in-italy-determinants-current-status-and-future-perspectives-a-scoping-review
#15
REVIEW
Claudio Di Lorito, Luca Castelletti, Ilaria Lega, Barbara Gualco, Franco Scarpa, Birgit Vӧllm
INTRODUCTION: Italy is the only country in the world to have closed forensic psychiatric hospitals and converted to fully-residential services. The international interest around this reform has not been matched by research. This scoping review aims to report the determinants of the reform, the most updated information on how the system operates, its benefits and its challenges. We further aim to discuss the implications for policy, research and practice. METHODS: 1...
November 2017: International Journal of Law and Psychiatry
https://www.readbyqxmd.com/read/29157274/evaluating-implementation-of-the-world-health-organization-s-strategic-approach-to-strengthening-sexual-and-reproductive-health-policies-and-programs-to-address-unintended-pregnancy-and-unsafe-abortion
#16
Shusmita Rashid, Julia E Moore, Caitlyn Timmings, Joshua P Vogel, Bela Ganatra, Dina N Khan, Radha Sayal, A Metin Gülmezoglu, Sharon E Straus
BACKGROUND: We conducted a process evaluation to assess how the World Health Organization's (WHO) Strategic Approach to strengthening sexual and reproductive health policies and programs ("the SA") was used in 15 countries that requested WHO's technical support in addressing unintended pregnancy and unsafe abortion. The SA is a three-stage planning, policy, and program implementation process. We used the social ecological model (SEM) to analyze the contextual factors that influenced SA implementation...
November 21, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29156809/adipose-derived-stem-cells-seeded-bladder-acellular-matrix-graft-silk-fibroin-enhances-bladder-reconstruction-in-a-rat-model
#17
Dongdong Xiao, Qiong Wang, Hao Yan, Xiangguo Lv, Yang Zhao, Zhe Zhou, Ming Zhang, Qian Sun, Kang Sun, Wei Li, Mujun Lu
The unfavourable clinical outcomes of host cell-seeded scaffolds for bladder augmentation warrant improved bioactive biomaterials. This study aimed to examine the feasibility of adipose-derived stem cells (ASCs)-seeded bilayer bladder acellular matrix graft (BAMG)-silk fibroin (SF) scaffold in enhancing bladder reconstruction. Sprague Dawley rats were randomly divided into three groups: the BAMG-SF-ASCs group, the acellular BAMG-SF group and the cystotomy group. The BAMG-SF-ASCs group was sampled at 2, 4 and 12 weeks, and compared with the other groups at 12 weeks...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156276/formation-and-degradation-of-n-oxide-venlafaxine-during-ozonation-and-biological-post-treatment
#18
Ines Zucker, Hadas Mamane, Alon Riani, Igal Gozlan, Dror Avisar
While ozonation is considered an efficient treatment to eliminate trace organic compounds (TrOCs) from secondary wastewater effluents, the presence and persistence of transformation products (TPs) resulting from ozonation of TrOCs is a major concern that should be assessed prior to effluent discharge to the environment. Venlafaxine (VLX), an environmentally relevant tertiary amine-containing TrOC, was chosen as the model for this study. TP analysis confirmed that the lone electron pair of the non-protonated amine are the predominant site of oxidant attack, and therefore strongly affected by pH value and VLX speciation...
November 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29155786/isolation-and-cultivation-of-adult-rat-cardiomyocytes
#19
Franziska Nippert, Rolf Schreckenberg, Klaus-Dieter Schlüter
In an intact heart, adjacent cells influence adult cardiomyocytes. With the method of isolation and cultivation of adult cardiomyocytes, a precise investigation of the behavior of these cells under specific treatments and environments is possible. This manuscript presents a protocol for successful isolation and cultivation of adult rat ventricular cardiomyocytes (ARVC). The rat is sacrificed by cervical dislocation under deep anesthesia. Then, the heart is extracted and the aorta is uncovered. Subsequently, perfusion on the Langendorff perfusion system with calcium depletion and collagenase treatment is performed...
October 19, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29155612/health-reform-and-utilization-of-high-volume-hospitals-for-complex-cancer-operations
#20
Andrew P Loehrer, David C Chang, Zirui Song, George J Chang
PURPOSE: Underinsured patients are less likely to receive complex cancer operations at hospitals with high surgical volumes (high-volume hospitals, or HVHs), which contributes to disparities in care. To date, the impact of insurance coverage expansion on site of complex cancer surgery remains unknown. METHODS: Using the 2006 Massachusetts coverage expansion as a natural experiment, we searched the Hospital Cost and Utilization Project state inpatient databases for Massachusetts and control states (New York, New Jersey, and Florida) between 2001 and 2011 to evaluate changes in the utilization of HVHs for resections of bladder, esophageal, stomach, pancreatic, rectal, or lung cancer after the expansion of insurance coverage...
November 20, 2017: Journal of Oncology Practice
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