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Pediatric IBD

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https://www.readbyqxmd.com/read/28533922/correlation-of-rapid-point-of-care-vs-send-out-fecal-calprotectin-monitoring-in-pediatric-inflammatory-bowel-disease
#1
Alexis Rodriguez, Lauren Yokomizo, Megan Christofferson, Danielle Barnes, Nasim Khavari, K T Park
AIM: To assess the correlation between the send-out enzyme-linked immuno sorbent assay (ELISA) and the point-of-care (POC) calprotectin test in pediatric inflammatory bowel disease (IBD) patients. METHODS: We prospectively collected stool samples in pediatric IBD patients for concomitant send-out ELISA analysis and POC calprotectin testing using the Quantum Blue(®) (QB) Extended immunoassay. Continuous results between 17 to 1000 μg/g were considered for comparison...
May 6, 2017: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28533920/inflammatory-bowel-disease-efficient-remission-maintenance-is-crucial-for-cost-containment
#2
REVIEW
Giovanni C Actis, Rinaldo Pellicano
The inflammatory bowel diseases (IBD) are chronic incurable inflammatory disorders of the gut. Some 10% run a downhill course, requiring emergency medical support and often surgery; another small subset are monogenic, and, threatening pediatric patients, are the challenge of these days. The majority of the IBDs, however, are polygenic low-penetrance diseases, running a lifetime waxing-and-waning course. The prevalent trend is towards a slow worsening and steady cost increase. Each and all drugs of the available arsenal exhibit strengths and weaknesses: Mesalamines are chiefly effectively for mild-moderate colitis, and do not work in Crohn's; steroids do not control some 40% of the ulcerative colitis cases, and are not indicated for Crohn's; thiopurines are effective in the maintenance of the IBDs but do not prevent relapses on withdrawal; biologics are still being used empirically (not monitored) causing further increase of their cost over that of hospitalization...
May 6, 2017: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28508156/pulse-wave-velocity-measurement-as-a-marker-of-arterial-stiffness-in-pediatric-inflammatory-bowel-disease-a-pilot-study
#3
Eberhard Lurz, Eliane Aeschbacher, Nicholas Carman, Susanne Schibli, Christiane Sokollik, Giacomo D Simonetti
In adults with inflammatory bowel disease (IBD), the incidence of cardiovascular events is increased, leading to long-term morbidity. Arterial stiffness (AS) measured by pulse wave velocity (PWV) is a validated early precursor of cardiovascular disease (CVD), and measurement of PWV was shown to be a feasible test in children. The aim of this study was to assess AS in children with IBD. In this prospective study, we determined PWV between the carotid and femoral artery (PWVcf) in 25 children and adolescents with IBD (11 females, median age 14...
May 15, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28507982/the-role-of-carrageenan-and-carboxymethylcellulose-in-the-development-of-intestinal-inflammation
#4
REVIEW
John Vincent Martino, Johan Van Limbergen, Leah E Cahill
Although the exact pathophysiology remains unknown, the development of inflammatory bowel disease (IBD) is influenced by the interplay between genetics, the immune system, and environmental factors such as diet. The commonly used food additives, carrageenan and carboxymethylcellulose (CMC), are used to develop intestinal inflammation in animal models. These food additives are excluded from current dietary approaches to induce disease remission in Crohn's disease such as exclusive enteral nutrition (EEN) using a polymeric formula...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28502439/pediatric-inflammatory-bowel-disease
#5
REVIEW
Máire A Conrad, Joel R Rosh
Inflammatory bowel disease (IBD), including Crohn disease, ulcerative colitis, and IBD-unspecified, is a chronic immune-mediated condition of the gastrointestinal tract in which the goal of treatment is to induce and maintain durable remission. In pediatrics, there is a wide spectrum of presenting symptoms, but esophagogastroduodenoscopy and colonoscopy are imperative to confirming the diagnosis. Treatment goals include achieving mucosal healing of the gastrointestinal tract, reaching growth potential, limiting medication toxicities, and optimizing quality of life for all patients...
June 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/28491862/comparison-of-fecal-calprotectin-methods-for-predicting-relapse-of-pediatric-inflammatory-bowel-disease
#6
Saranya Kittanakom, Md Sharif Shajib, Kristine Garvie, Joceline Turner, Dan Brooks, Sufian Odeh, Robert Issenman, V Tony Chetty, Joseph Macri, Waliul I Khan
Background. Pediatric inflammatory bowel disease (IBD) is on the rise worldwide. Endoscopies are necessary for IBD assessment but are invasive, expensive, and inconvenient. Recently, fecal calprotectin (FCal) was proposed as a noninvasive and specific marker of gut inflammation. We evaluated the analytical performance of three FCal assays and their clinical performance in predicting relapse in pediatric IBD. Methods. This study used 40 pediatric IBD and 40 random non-IBD patients' fecal samples. Two automated ELISAs (Bühlmann and PhiCal® Calprotectin-EIA) and an EliA (Phadia 250 EliA-Calprotectin) were used to evaluate the analytical performance...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28480654/vitamin-d-status-and-bone-mineral-density-in-children-with-inflammatory-bowel-disease-compared-to-those-with-functional-abdominal-pain
#7
Jenny Sohn, Eun Jae Chang, Hye Ran Yang
Low vitamin D has been implicated in reduced bone mineral density (BMD) in children with inflammatory bowel disease (IBD). Our study aimed to evaluate differences in serum 25-hydroxyvitamin D (25[OH]D) and total body less head (TBLH) BMD z-scores in children with Crohn's disease (CD), ulcerative colitis (UC), and those with abdominal pain-related functional gastrointestinal disorder (AP-FGID) as the control group. We also examined the correlation between serum 25(OH)D and TBLH BMD z-score, and factors that affect each of these parameters...
June 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28472874/associations-of-seasonal-patterns-and-vitamin-d-levels-with-onset-and-flares-of-pediatric-inflammatory-bowel-disease
#8
Yael Brandvayman, Firas Rinawi, Raanan Shamir, Amit Assa
BACKGROUND: As inflammatory bowel disease (IBD) might be associated with environmental factors such as seasonal patterns and low vitamin D levels we aimed to assess their association with IBD onset and flares in a large cohort of children. METHODS: The records of 623 pediatric onset IBD patients were reviewed retrospectively including age at onset, gender, severity indices, month of first symptom, and vitamin D levels at diagnosis. For a subgroup of patients, data included date of first flare and vitamin D levels during flare and remission...
May 4, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28462785/-children-with-inflammatory-bowel-disease-assessment-of-the-transition-from-the-pediatric-to-the-adult-care-unit
#9
A Gerfaud, L Bridoux-Henno, J-F Bretagne, L Siproudhis, G Bouguen, A Dabadie
AIM: Assess the transition of children followed for inflammatory bowel disease (IBD) to the adult gastroenterology care unit and the development of joint medical visits (JMVs). PATIENTS AND METHOD: This study was conducted at the Rennes University Hospital (Brittany, France). All patients with IBD and relayed to an adult gastroenterologist (GE) between 2000 and 2014 were included. The following medical data were collected: age, gender, clinical status, disease activity, type of follow-up (freelance or at hospital), medical history, disease locations, and treatments received...
April 24, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28462126/reactive-oxygen-species-and-antioxidant-defense-in-human-gastrointestinal-diseases
#10
REVIEW
Peter Patlevič, Janka Vašková, Pavol Švorc, Ladislav Vaško, Pavol Švorc
Crohn's disease and ulcerative colitis, known together as inflammatory bowel diseases (IBDs), and celiac disease are the most common disorders affecting not only adults but also children. Both IBDs and celiac disease are associated with oxidative stress, which may play a significant role in their etiologies. Reactive oxygen species (ROS) such as superoxide radicals (O2•(-)), hydroxyl radicals (•OH), hydrogen peroxide (H2O2), and singlet oxygen ((1)O2) are responsible for cell death via oxidation of DNA, proteins, lipids, and almost any other cellular constituent...
December 2016: Integr Med Res
https://www.readbyqxmd.com/read/28430891/development-and-validation-of-diagnostic-criteria-for-ibd-subtypes-with-an-emphasis-on-ibd-unclassified-in-children-a-multicenter-study-from-the-pediatric-ibd-porto-group-of-espghan
#11
Liron Birimberg-Schwartz, David M Zucker, Amichay Akriv, Salvatore Cucchiara, Fiona L Cameron, David C Wilson, Iza Lazowska, Lambri Yianni, Siba Prosad Paul, Claudio Romano, Sanja Kolacek, Stephan Buderus, Anders Pærregaard, Richard K Russell, Johanna C Escher, Dan Turner
Background: The revised Porto criteria identify subtypes of pediatric inflammatory bowel diseases: ulcerative colitis (UC), atypical UC, Inflammatory Bowel Disease Unclassified (IBDU), and Crohn's disease (CD). In continuation of the Porto criteria, we aimed to derive and validate criteria for standardizing the classification of the IBD subtypes. Methods: This was a multicenter retrospective longitudinal study from 23 centers affiliated with the Porto-group of ESPGHAN...
April 18, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28426457/race-differences-in-initial-presentation-early-treatment-and-1-year-outcomes-of-pediatric-crohn-s-disease-results-from-the-improvecarenow-network
#12
Jennifer L Dotson, Michele Cho, Josh Bricker, Michael D Kappelman, Deena J Chisolm, Gitit Tomer, Wallace V Crandall
BACKGROUND: Racially disparate care has been shown to contribute to suboptimal health care outcomes for minorities. Using the ImproveCareNow network, we investigated differences in management and outcomes of pediatric patients with Crohn's disease at diagnosis and 1-year postdiagnosis. METHODS: ImproveCareNow is a learning health network for pediatric inflammatory bowel disease. It contains prospective, longitudinal data from outpatient encounters. This retrospective study included all patients with Crohn's disease ≤21 years, September 2006 to October 2014, with the first recorded encounter ≤90 days from date of diagnosis and an encounter 1 year ±60 days...
May 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28422189/exome-analysis-of-rare-and-common-variants-within-the-nod-signaling-pathway
#13
Gaia Andreoletti, Valentina Shakhnovich, Kathy Christenson, Tracy Coelho, Rachel Haggarty, Nadeem A Afzal, Akshay Batra, Britt-Sabina Petersen, Matthew Mort, R Mark Beattie, Sarah Ennis
Pediatric inflammatory bowel disease (pIBD) is a chronic heterogeneous disorder. This study looks at the burden of common and rare coding mutations within 41 genes comprising the NOD signaling pathway in pIBD patients. 136 pIBD and 106 control samples underwent whole-exome sequencing. We compared the burden of common, rare and private mutation between these two groups using the SKAT-O test. An independent replication cohort of 33 cases and 111 controls was used to validate significant findings. We observed variation in 40 of 41 genes comprising the NOD signaling pathway...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28417994/trends-in-epidemiology-of-pediatric-inflammatory-bowel-disease-in-canada-distributed-network-analysis-of-multiple-population-based-provincial-health-administrative-databases
#14
Eric I Benchimol, Charles N Bernstein, Alain Bitton, Matthew W Carroll, Harminder Singh, Anthony R Otley, Maria Vutcovici, Wael El-Matary, Geoffrey C Nguyen, Anne M Griffiths, David R Mack, Kevan Jacobson, Nassim Mojaverian, Divine Tanyingoh, Yunsong Cui, Zoann J Nugent, Janie Coulombe, Laura E Targownik, Jennifer L Jones, Desmond Leddin, Sanjay K Murthy, Gilaad G Kaplan
OBJECTIVES: The incidence of pediatric-onset inflammatory bowel disease (IBD) is increasing worldwide. We used population-based health administrative data to determine national Canadian IBD incidence, prevalence, and trends over time of childhood-onset IBD. METHODS: We identified children <16 years (y) diagnosed with IBD 1999-2010 from health administrative data in five provinces (Alberta, Manitoba, Nova Scotia, Ontario, Quebec), comprising 79.2% of the Canadian population...
April 18, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28394807/patient-health-communication-mediating-effects-between-gastrointestinal-symptoms-and-gastrointestinal-worry-in-pediatric-inflammatory-bowel-disease
#15
James W Varni, Robert J Shulman, Mariella M Self, Shehzad A Saeed, Ashish S Patel, Samuel Nurko, Deborah A Neigut, Miguel Saps, George M Zacur, Chelsea V Dark, Cristiane B Bendo, John F Pohl
BACKGROUND: To investigate the effects of patient health communication regarding their inflammatory bowel disease (IBD) to their health care providers and significant others in their daily life as a mediator in the relationship between gastrointestinal symptoms and gastrointestinal worry in pediatric patients. METHODS: The Pediatric Quality of Life Inventory Gastrointestinal Symptoms, Gastrointestinal Worry, and Communication Scales, and Pediatric Quality of Life Inventory 4...
May 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28394806/immunogenicity-of-pertussis-booster-vaccination-in-children-and-adolescents-with-inflammatory-bowel-disease-a-controlled-study
#16
Aleksandra Banaszkiewicz, Agnieszka Gawronska, Beata Klincewicz, Anna Kofla-Dłubacz, Urszula Grzybowska-Chlebowczyk, Ewa Toporowska-Kowalska, Ilona Malecka, Joanna Stryczynska-Kazubska, Wojciech Feleszko, Izabella Lazowska-Przeorek, Katarzyna Karolewska-Bochenek, Jarosław Walkowiak, Janusz Slusarczyk, Andrzej Radzikowski, Urszula Demkow, Piotr Albrecht
BACKGROUND: There are limited data on antibody response to vaccination in patients with inflammatory bowel disease (IBD). In this study, we aimed to assess the immunogenicity of a booster dose of pertussis vaccine in pediatric patients with IBD and to compare their response with healthy controls. METHODS: We performed a multicenter, prospective, and controlled trial. Eligible for inclusion were children and adolescents (11-18 year olds), with no history of pertussis booster immunization after the age of 6 years or history of pertussis...
May 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28390159/the-natural-history-of-primary-sclerosing-cholangitis-in-781-children-a-multicenter-international-collaboration
#17
Mark R Deneau, Wael El-Matary, Pamela L Valentino, Reham Abdou, Khaled Alqoaer, Mansi Amin, Achiya Z Amir, Marcus Auth, Fateh Bazerbachi, Annemarie Broderick, Albert Chan, Jillian Cotter, Sylvia Doan, Mounif El-Youssef, Federica Ferrari, Katryn N Furuya, Madeleine Gottrand, Frederic Gottrand, Nitika Gupta, Matjaz Homan, Binita M Kamath, Kyung Mo Kim, Kaija-Leena Kolho, Anastasia Konidari, Bart Koot, Raffaele Iorio, Oren Ledder, Cara Mack, Mercedes Martinez, Tamir Miloh, Parvathi Mohan, Niamh O'Cathain, Alexandra Papadopoulou, Amanda Ricciuto, Lawrence Saubermann, Pushpa Sathya, Eyal Shteyer, Vratislav Smolka, Atushi Tanaka, Raghu Varier, Veena Venkat, Bernadette Vitola, Miriam B Vos, Marek Woynarowski, Jason Yap, M K Jensen
BACKGROUND: There are limited data on the natural history of primary sclerosing cholangitis (PSC) in children. We aimed to describe the disease characteristics and long-term outcomes of pediatric PSC. METHODS: We retrospectively collected all pediatric PSC cases from 36 participating institutions and conducted a survival analysis from the date of PSC diagnosis to dates of diagnosis of portal hypertensive or biliary complications, cholangiocarcinoma, liver transplantation, or death...
April 8, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28378134/pediatric-short-bowel-syndrome-and-subsequent-development-of-inflammatory-bowel-disease-an-illustrative-case-and-literature-review
#18
Katherine J Baxter, Jahnavi K Srinivasan, Thomas R Ziegler, Tanvi Dhere, Richard R Ricketts, Megan M Durham
Short bowel syndrome (SBS) in neonates is an uncommon but highly morbid condition. As SBS survival increases, physiologic complications become more apparent. Few reports in the literature elucidate outcomes for adults with a pediatric history of SBS. We present a case report of a patient, born with complicated gastroschisis resulting in SBS at birth, who subsequently developed symptoms and pathologic changes of inflammatory bowel disease (IBD) as an adult. The patient lived from age 7, after a Bianchi intestinal lengthening procedure, to age 34 independent of parenteral nutrition (PN), but requiring hydration fluid via G-tube...
June 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28373409/activation-of-tgf-%C3%AE-activated-kinase-1-promotes-colon-mucosal-pathogenesis-in-inflammatory-bowel-disease
#19
Zhiwei Liu, Fansheng Kong, Jefferson E Vallance, Eleana Harmel-Laws, Surya Amarachintha, Kris A Steinbrecher, Michael J Rosen, Sandip Bhattacharyya
The etiology and mechanisms for inflammatory bowel disease (IBD) are incompletely known. Determination of new, clinically important mechanisms for intestinal inflammation is imperative for developing effective therapies to treat IBD We sought to define a widespread mechanism for colon mucosal inflammation via the activation of TGF-β activated Kinase 1 (TAK1), a central regulator of cellular inflammatory actions. Activation of TAK1 and the downstream inflammatory signaling mediators was determined in pediatric patients with ulcerative colitis (UC) or Crohn's disease (CD) as well as in DSS-induced and spontaneous IBD in mice...
April 2017: Physiological Reports
https://www.readbyqxmd.com/read/28368365/mind-body-interventions-for-pediatric-inflammatory-bowel-disease
#20
REVIEW
Ann Ming Yeh, Anava Wren, Brenda Golianu
Pediatric inflammatory bowel disease is an autoimmune disease that causes chronic inflammation of the gastrointestinal mucosa. There is emerging evidence that the brain-gut connection affects inflammatory bowel disease (IBD) patients more than previously thought. This is evidenced by comorbid mood disorders, irritable bowel symptoms concurrent with quiescent IBD, and the potential of psychosocial stressors to trigger IBD flares. Mind-body interventions such as psychotherapy, relaxation, mindfulness, biofeedback, yoga, and clinical hypnosis offer an adjunct to standard medical treatment for IBD...
April 3, 2017: Children
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