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Pediatric IBD

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https://www.readbyqxmd.com/read/28721977/a-cross-sectional-survey-of-saudi-gastroenterologists-transition-strategies-for-adolescents-with-inflammatory-bowel-disease
#1
Elaf Al-Jahdali, Mahmoud Mosli, Omar Saadah
BACKGROUND/AIMS: The transition of adolescents with inflammatory bowel disease (IBD) from pediatric to adult care requires a well-structured standardized protocol to ensure the delivery of optimal healthcare and decrease the risk of nonadherence, hospitalizations, and complications. The aims of this survey are to evaluate current IBD transition practices adopted by gastroenterology services across the Kingdom of Saudi Arabia (KSA) and to identify the major challenges standing in the way of implementing effective transition strategies from the perspectives of pediatric and adult gastroenterologists...
July 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28705682/increased-bone-matrix-mineralization-in-treatment-na%C3%A3-ve-children-with-inflammatory-bowel-disease
#2
Barbara M Misof, Paul Roschger, Klaus Klaushofer, Frank Rauch, Jinhui Ma, David R Mack, Leanne M Ward
Inflammatory bowel disease (IBD) affects many organ systems including the skeleton. In children with IBD, bone mineral density (BMD) and bone turnover are frequently low. Disturbances in bone mineralization density distribution (BMDD) are linked to alterations in bone material strength; however, BMDD has not previously been reported in children with chronic inflammatory disorders. The aim of this study was to characterize BMDD based on quantitative backscatter electron imaging in cancellous (Cn.) and cortical (Ct...
July 10, 2017: Bone
https://www.readbyqxmd.com/read/28704225/intravenous-iron-sucrose-for-treatment-of-iron-deficiency-anemia-in-pediatric-inflammatory-bowel-disease
#3
Ronen E Stein, Kristen Plantz, Elizabeth C Maxwell, Petar Mamula, Robert N Baldassano
OBJECTIVES: Iron deficiency anemia (IDA) is a common complication of pediatric inflammatory bowel disease (IBD), yet the effectiveness of oral iron supplementation is limited. Intravenous iron sucrose is an effective and safe alternative treatment for IDA in adults with IBD, but its role in the treatment of IDA in pediatric IBD is unclear. The primary aim of this study was to evaluate the use of iron sucrose in pediatric IBD subjects with IDA and determine the clinical response as measured by improvement in hemoglobin concentration...
July 12, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28700535/vitamin-d-status-is-associated-with-hepcidin-and-hemoglobin-concentrations-in-children-with-inflammatory-bowel-disease
#4
Sana Syed, Ellen S Michalski, Vin Tangpricha, Supavit Chesdachai, Archana Kumar, Jarod Prince, Thomas R Ziegler, Parminder S Suchdev, Subra Kugathasan
BACKGROUND: Anemia, iron deficiency, and hypovitaminosis D are well-known comorbidities in inflammatory bowel disease (IBD). Epidemiologic studies have linked vitamin D deficiency with increased risk of anemia, and in vitro studies suggest that vitamin D may improve iron recycling through downregulatory effects on hepcidin and proinflammatory cytokines. METHODS: We aimed to investigate the association of vitamin D status with inflammation, iron biomarkers, and anemia in pediatric IBD...
July 11, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28696957/association-of-inflammatory-bowel-disease-and-urolithiasis-in-hospitalized-pediatric-patients
#5
Christopher M Stark, Gregory H Gorman, Cade M Nylund
BACKGROUND: Urolithiasis is rare in pediatric patients. All patients with inflammatory bowel disease (IBD) have an increased risk of urolithiasis, but this risk is poorly quantified in children. The objective of this study is to evaluate the association of IBD with urolithiasis, assess surgical outcomes, and analyze the financial burden for children hospitalized with urolithiasis and comorbid IBD. METHODS: The triennial Healthcare Cost and Utilization Project Kids' Inpatient Database for years 1997 to 2012 was used to evaluate the association between urolithiasis and IBD in hospitalized, nonpregnant children ages 5 to 20 years old...
July 10, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28692447/communicating-the-benefits-and-risks-of-inflammatory-bowel-disease-therapy-to-patients-and-families
#6
Joseph A Picoraro, Joel R Rosh
PURPOSE OF REVIEW: Treatment options for inflammatory bowel disease (IBD) have rapidly expanded as the treatment paradigm has shifted from controlling symptoms to reducing lifetime inflammatory burden. Families are confronted with the actual and perceived risks of this ever-expanding array of choices. We aim to review the shared decision-making process in pediatric IBD to ensure an optimal therapeutic plan for the child and their family. RECENT FINDINGS: Mucosal healing is a critical treatment target in pediatric IBD but it may not coincide with clinical symptoms...
July 7, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28658154/16s-sequencing-and-functional-analysis-of-the-fecal-microbiome-during-treatment-of-newly-diagnosed-pediatric-inflammatory-bowel-disease
#7
James J Ashton, Catherine M Colquhoun, David W Cleary, Tracy Coelho, Rachel Haggarty, Imke Mulder, Akshay Batra, Nadeem A Afzal, R Mark Beattie, Karen P Scott, Sarah Ennis
The human microbiome is of considerable interest to pediatric inflammatory bowel disease (PIBD) researchers with 1 potential mechanism for disease development being aberrant immune handling of the intestinal bacteria. This study analyses the fecal microbiome through treatment in newly diagnosed PIBD patients and compares to cohabiting siblings where possible. Patients were recruited on clinical suspicion of PIBD before diagnosis. Treatment-naïve fecal samples were collected, with further samples at 2 and 6 weeks into treatment...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28652662/inflammatory-bowel-disease-incidence-in-czech-children-a-regional-prospective-study-2000-2015
#8
Jan Schwarz, Josef Sýkora, Dominika Cvalínová, Renáta Pomahačová, Jana Klečková, Martin Kryl, Petr Včelák
AIM: To examine the incidence and trends in pediatric inflammatory bowel diseases (IBDs) over 2000-2015 and project the incidence to 2018. METHODS: A 16-year prospective study of IBD patients < 19 years of age was conducted in the Czech Republic (the Pilsen region). All incident IBD cases within a well-defined geographical area were retrieved from a prospectively collected computerized clinical database. Historical Czech data were used for comparison (1990-2001)...
June 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28644354/development-and-function-of-immune-cells-in-an-adolescent-patient-with-a-deficiency-in-the-interleukin-10-receptor
#9
Sharon Veenbergen, Marieke A van Leeuwen, Gertjan J Driessen, Rogier Kersseboom, Lilian F de Ruiter, Rolien H C Raatgeep, Dicky J Lindenbergh-Kortleve, Ytje Simons-Oosterhuis, Katharina Biermann, Dicky J J Halley, Lissy de Ridder, Johanna C Escher, Janneke N Samsom
OBJECTIVE: Monogenic defects in the interleukin-10 (IL-10) pathway are extremely rare and cause infantile-onset inflammatory bowel disease (IBD)-like pathology. Understanding how immune responses are dysregulated in monogenic IBD-like diseases can provide valuable insight in "classical" IBD pathogenesis. Here, we studied long-term immune cell development and function in an adolescent IL-10 receptor (IL10RA)-deficient patient who presented in infancy with severe colitis and fistulizing perianal disease and is currently treated with immune suppressants...
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28644308/the-use-of-5-aminosalicylic-acid-in-children-and-adolescents-with-inflammatory-bowel-disease
#10
Christiane Sokollik, Nicolas Fournier, David Rizzuti, Christian P Braegger, Andreas Nydegger, Susanne Schibli, Johannes Spalinger
BACKGROUND: In ulcerative colitis (UC) 5-aminosalicylic acid (5-ASA) is recommended as primary therapy for mild to moderate disease. Topical 5-ASA has been proven especially effective. In Crohn's disease (CD) the evidence for a beneficial role of 5-ASA is weak. We investigated the use of topical and systemic 5-ASA therapy in children and adolescents with inflammatory bowel disease. MATERIALS AND METHODS: Data of patients younger than 18 years, registered between April 2008 and December 2015 in the Swiss Inflammatory Bowel Disease Cohort, were analyzed...
June 21, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28644180/mucosal-healing-in-clinical-practice-a-single-center-pediatric-ibd-experience
#11
Savini L Santha, Prabhu R Shankar, Anqi Pan, Bess Schoen, Subra Kugathasan, Cary G Sauer
BACKGROUND: Mucosal healing (MH) is associated with improved clinical outcomes in patients with Crohn's disease (CD) and ulcerative colitis (UC). MH as a target for treatment has been suggested, although there is little pediatric data. The goal of this study was to evaluate MH in clinical practice in pediatric patients with inflammatory bowel disease in clinical remission. METHODS: A retrospective review of electronic health record data was performed on all patients with CD or UC who underwent at least 2 colonoscopies from 2010 through 2016...
August 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28643816/-budd-chiari-syndrome-and-ulcerative-colitis-in-an-adolescent
#12
Federico Marchetti, Martina Mainetti, Michela Giovannini, Cristina Morelli
In patients with inflammatory bowel disease (IBD) there is an increased incidence of thromboembolic events. We report a case of a female, age 14, with a 6 months history of diarrhea with occasional presence of red blood and with a very distended abdomen with evident ascites. The diagnosis was Budd-Chiari syndrome (BCS) in ulcerative colitis (UC). Therapy with subcutaneous low molecular weight heparin, methylprednisolone, mesalazine was started. Clinical and radiological features quickly improved. No thrombophilia abnormality nor other risk factor for thrombosis were detected...
May 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28638582/an-overview-of-inflammatory-bowel-disease-general-consideration-and-genetic-screening-approach-in-diagnosis-of-early-onset-subsets
#13
REVIEW
Shahram Nemati, Shahram Teimourian
Inflammatory bowel disease (IBD) is the consequence of an aberrant hemostasis of the immune cells at the gut mucosal border. Based on clinical manifestation, laboratory tests, radiological studies, endoscopic and histological features, this disease is divided into three main types including Crohn's disease (CD), Ulcerative colitis (UC), and IBDunclassified (IBD-U). IBD is frequently presented in adults, but about 20% of IBD cases are diagnosed during childhood called pediatric IBD (PIBD). Some patients in the latter group emerge the first symptoms during infancy or under 5 years of age named infantile and very early onset IBD (VEO-IBD), respectively...
April 2017: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28612637/treatment-options-for-children-and-adolescents-with-inflammatory-bowel-disease-is-granulomonocytapheresis-an-effective-alternative-to-drug-therapy
#14
Tomotaka Tanaka, Takayuki Yamamoto, Koji Sawada, Rodolfo Sacco
Patients with inflammatory bowel diseases (IBD) require life-long medications, which even if effective have the potential to cause adverse effects as additional morbidity factors. In pediatric patients, drug therapy has more serious limitations, including impaired physical and mental development. A non-drug therapeutic option is believed to be depletion of elevated and activated granulocytes and monocytes known to release inflammatory cytokines, like the CD14+CD16+ monocyte phenotype known to release tumor necrosis factor-α...
June 28, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28611517/urinary-metabolic-insights-into-host-gut-microbial-interactions-in-healthy-and-ibd-children
#15
Francois-Pierre Martin, Ming-Ming Su, Guo-Xiang Xie, Seu Ping Guiraud, Martin Kussmann, Jean-Philippe Godin, Wei Jia, Andreas Nydegger
AIM: To identify metabolic signatures in urine samples from healthy and inflammatory bowel disease (IBD) children. METHODS: We applied liquid chromatography and gas chromatography coupled to targeted mass spectrometry (MS)-based metabolite profiling to identify and quantify bile acids and host-gut microbial metabolites in urine samples collected from 21 pediatric IBD patients monitored three times over one year (baseline, 6 and 12 mo), and 27 age- and gender-matched healthy children...
May 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28611515/transition-of-pediatric-to-adult-care-in-inflammatory-bowel-disease-is-it-as-easy-as-1-2-3
#16
REVIEW
Anita Afzali, Ghassan Wahbeh
Inflammatory bowel disease (IBD) is a heterogeneous group of chronic diseases with a rising prevalence in the pediatric population, and up to 25% of IBD patients are diagnosed before 18 years of age. Adolescents with IBD tend to have more severe and extensive disease and eventually require graduation from pediatric care toadult services. The transition of patients from pediatric to adult gastroenterologists requires careful preparation and coordination, with involvement of all key players to ensure proper collaboration of care and avoid interruption in care...
May 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28606846/agreement-between-home-based-measurement-of-stool-calprotectin-and-elisa-results-for-monitoring-inflammatory-bowel-disease-activity
#17
Anke Heida, Mariska Knol, Anneke Muller Kobold, Josette Bootsman, Gerard Dijkstra, Patrick F van Rheenen
BACKGROUND & AIMS: An increasing number of physicians use repeated measurements of stool calprotectin to monitor intestinal inflammation in patients with inflammatory bowel diseases (IBDs). A lateral flow-based rapid test allows patients to measure their own stool calprotectin values at home. The test comes with a software application (IBDoc; Bühlmann Laboratories AG, Schönenbuch, Switzerland) that turns a smartphone camera into a results reader. We compared results from this method with those from the hospital-based reader (Quantum Blue; Bühlmann Laboratories AG) and enzyme-linked immunosorbent assay (ELISA) analysis...
June 10, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28605483/vedolizumab-in-pediatric-inflammatory-bowel-disease-a-retrospective-multi-center-experience-from-the-paediatric-ibd-porto-group-of-espghan
#18
Oren Ledder, Amit Assa, Arie Levine, Johanna C Escher, Lissy de Ridder, Frank Ruemmele, Neil Shah, Ron Shaoul, Victorien M Wolters, Astor Rodrigues, Holm H Uhlig, Carsten Posovsky, Kaija-Leena Kolho, Christian Jakobsen, Shlomi Cohen, Dror S Shouval, Tim de Meij, Javier Martin-de-Carpi, Lisa Richmond, Jiri Bronsky, Mira Friedman, Dan Turner
Background: Vedolizumab, an anti-integrin antibody, has proven to be effective in adults with Inflammatory Bowel Disease (IBD), but the data in pediatrics are limited. We describe the short-term effectiveness and safety of vedolizumab in a European multi-center pediatric IBD cohort. Method: Retrospective review of children (2-18 years) treated with vedolizumab from 19 centers affiliated with the Paediatric IBD Porto group of ESPGHAN. Primary outcome was week 14 corticosteroid-free remission (CFR)...
June 9, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28604511/incidence-and-risk-factors-for-perianal-disease-in-pediatric-crohn-s-disease-patients-followed-in-cedata-gpge-registry
#19
Annecarin Brückner, Katharina J Werkstetter, Jan de Laffolie, Claudia Wendt, Christine Prell, Tanja Weidenhausen, Klaus P Zimmer, Sibylle Koletzko
BACKGROUND AND AIMS: Perianal disease (PD) with fistula and/or abscess formation is a severe complication in Crohn's disease (CD). We examined prevalence, incidence and risk factors for PD development in a pediatric CD cohort. METHODS: CD patients from the prospective, multi-center registry for inflammatory bowel disease from Germany and Austria (CEDATA-GPGE) were included if diagnosed ≤18 years of age, registered within three months after diagnosis, and having at least two follow-up visits within the first year of registration...
June 9, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28604509/granulocyte-and-monocyte-apheresis-for-induction-of-remission-in-children-with-new-onset-inflammatory-bowel-colitis
#20
Helena Rolandsdotter, Michael Eberhardson, Ulrika L Fagerberg, Yigael Finkel
OBJECTIVE: To study the effect of granulocyte and monocyte apheresis (GMA) with mesalazine for induction of remission in pediatric patients with newly onset chronic inflammatory bowel disease (IBD) colitis. METHODS: Thirteen pediatric patients with newly onset extensive IBD colitis were investigated per the ECCO/ESPGHAN IBD protocol. Of these 13, 12 received ten treatments with Adacolumn (ADA) during a median of 6.25 weeks in combination with low-to-moderate doses of mesalazine, which was continued after apheresis...
June 9, 2017: Journal of Pediatric Gastroenterology and Nutrition
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