Kenyaita M Hodge, Vasyl Zhabotynsky, Amber A Burt, Brian S Carter, Rebecca C Fry, Jennifer Helderman, Julie A Hofheimer, Elisabeth C McGowan, Charles R Neal, Steven L Pastyrnak, Lynne M Smith, Sheri A DellaGrotta, Lynne M Dansereau, Barry M Lester, Carmen J Marsit, T Michael O'Shea, Todd M Everson
BACKGROUND: Bronchopulmonary dysplasia (BPD), a common morbidity among very preterm infants, is associated with chronic disease and neurodevelopmental impairments. A hypothesized mechanism for these outcomes lies in altered glucocorticoid (GC) activity. We hypothesized that BPD and its treatments may result in epigenetic differences in the hypothalamic-pituitary-adrenal (HPA) axis, which is modulated by GC, and could be ascertained using an established GC risk score and DNA methylation (DNAm) of HPA axis genes...
March 13, 2024: Pediatric Research