Maria Ubals, Patricia Nadal-Baron, Maider Arando, Ángel Rivero, Adrià Mendoza, Vicent Descalzo Jorro, Dan Ouchi, Clara Pérez-Mañá, Marlene Álvarez, Andrea Alemany, Yannick Hoyos-Mallecot, Ethan Nunley, Nicole A P Lieberman, Alexander L Greninger, Cristina Galván-Casas, Clara Suñer, Camila G-Beiras, Roger Paredes, Alicia Rodríguez-Gascón, Andrés Canut, Vicente García-Patos, Magí Farré, Michael Marks, Lorenzo Giacani, Martí Vall-Mayans, Oriol Mitjà
BACKGROUND: Management of syphilis, a sexually transmitted infection (STI) with increasing incidence, is challenged by drug shortages, scarcity of randomised trial data, an absence of non-penicillin alternatives for pregnant women with penicillin allergy (other than desensitisation), extended parenteral administration for neurosyphilis and congenital syphilis, and macrolide resistance. Linezolid was shown to be active against Treponema pallidum, the causative agent of syphilis, in vitro and in the rabbit model...
January 8, 2024: Lancet Infectious Diseases