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https://www.readbyqxmd.com/read/29706150/neurosyphilis-mighty-imitator-forays-with-benign-presentation-and-unique-neuroimaging-findings
#1
Harmanpreet Tiwana, Aiesha Ahmed
Background: Common causes of temporal lobe hyper intensities are central nervous system infections like herpes simplex encephalitis, Lyme disease, limbic encephalitis and vascular pathology like Cerebral Autosomal Dominant Arteriopathy with Subcortical infarcts and Leukoencephalopathy. Methods: Personal assessment, laboratory data analysis and neuroimaging for the patient who was admitted to a central Pennsylvania tertiary care referral centre were conducted. Results: A 52-year-old male presented with a 1-year history of diffuse dysesthesia in upper and lower extremities with associated intermittent headaches and neck stiffness...
April 30, 2018: Sexual Health
https://www.readbyqxmd.com/read/29682240/extending-the-range-of-differential-diagnosis-of-chronic-traumatic-encephalopathy-of-the-boxer-insights-from-a-case-report
#2
Leonardo Caixeta, Iron Dangoni, Rafael Dias de Sousa, Pedro Paulo Dias Soares, Andreia Costa Rabelo Mendonça
Sports activities associated with repetitive cranial trauma have become a fad and are popular in gyms and even among children. It is important to consistently characterize the consequences of such sports activities in order to better advise society on the real risks to the central nervous system. We present the case of a former boxer reporting cognitive and behavioral symptoms that began six years after his retirement as a boxer, evolving progressively with parkinsonian and cerebellar features suggestive of probable chronic traumatic encephalopathy (CTE)...
January 2018: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29674128/diagnostic-value-of-cerebrospinal-fluid-cxcl13-for-acute-lyme-neuroborreliosis-a-systemic-review-and-meta-analysis
#3
REVIEW
Tobias Armin Rupprecht, Kirsi Marjaana Manz, Volker Fingerle, Christian Lechner, Matthias Klein, Markus Pfirrmann, Uwe Koedel
OBJECTIVES: The utility of cerebrospinal fluid (CSF) CXCL13 for diagnosis of acute Lyme neuroborreliosis (LNB) has been debated and the test is not yet routinely performed. This study's aim was to evaluate its overall diagnostic accuracy through meta-analysis. METHODS: Electronic searches in PubMed MEDLINE and Web of Science were performed to identify relevant articles published before January 2018. A summary receiver operating characteristic curve and an optimal cut-off were estimated modeling multiple cut-offs...
April 16, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29666731/ischemic-stroke-in-an-hiv-positive-patient-an-initial-presentation-of-neurosyphilis
#4
Kalimullah Jan, Rebecca Hoe Hui Min, Tan Seow Yen, Shekhawat Ravindra Singh
Ischemic stroke occurring in patients with human immunodeficiency virus (HIV) needs to be approached with a vast differential diagnosis in mind. We report a case of middle-aged male patient with immune reconstituted HIV on therapy without known cardiovascular risk factors who had a right middle cerebral artery territory infarct. After a thorough evaluation, he received a final diagnosis of neurosyphilis-associated vasculitis leading to stroke. He recovered without any neurological deficits following treatment with intravenous benzylpenicillin...
2018: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/29624563/different-faces-of-neurosyphilis
#5
Agnieszka Chrząszcz-Włodarczyk, Adam Włodarczyk, Joanna Szarmach
No abstract text is available yet for this article.
April 5, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29620006/electroclinical-and-radiological-observation-of-dysfunctional-zones-in-a-patient-with-neurosyphilis
#6
Katsuya Sakai, Shogo Yazawa, Akiko Sugimoto, Koichi Nakao, Kazuhito Tsuruta, Eiji Ochiai, Yukiko Suzuki, Masao Matsuhashi
We report a 33-year-old Japanese man who suffered from repetitive generalized tonic-clonic seizures which were medically intractable. Neurosyphilis was serologically diagnosed in blood and cerebrospinal fluid, and penicillin G (PcG) was consequently effective. The EEG during PcG pre-treatment showed frequent right occipital spikes and right frontocentral slow waves, which disappeared after treatment. During pre-treatment, positron emission tomography with 18-fluorodeoxyglucose and Tc-99m ethyl cysteinate dimer single-photon emission computed tomography revealed occipital hypermetabolism and hyperperfusion ("hot" area) and fronto-temporo-parietal hypometabolism and hypoperfusion ("cool" area) over the right hemisphere...
April 5, 2018: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/29606102/the-performance-of-rapid-plasma-reagin-rpr-titer-in-hiv-negative-general-paresis-after-neurosyphilis-therapy
#7
Ying Jiang, Ruihui Weng, Yuefeng Zhang, Rong Fan, Yulun Liu, Zhigang Chen, Fuhua Peng, Yong Chen, Xiaohong Chen
BACKGROUND: Repeated nontreponemal serologic test for syphilis titers is recommended to evaluate treatment response. However, it is unknown whether serum rapid plasma reagin (RPR) titer can serve as a surrogate for determining the efficacy of treatment in general paresis (GP) remains unknown. METHODS: We retrospectively reviewed data from 105 GP patients, who were divided into two groups (62 CSF RPR+ patients and 43 CSF RPR- patients) according to reactive RPR test status in CSF...
April 2, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29604973/other-central-nervous-system-infections-cytomegalovirus-mycobacterium-tuberculosis-and-treponema-pallidum
#8
Christina M Marra
Human immunodeficiency virus (HIV)-infected individuals are particularly susceptible to several central nervous system infections: human cytomegalovirus, which may cause encephalitis, ventriculitis, polyradiculitis, or polyradiculomyelitis; Mycobacterium tuberculosis, which can cause meningitis or space-occupying lesions; and Treponema pallidum subspecies pallidum (T. pallidum), which affects the meninges, cerebrospinal fluid, cranial nerves, and vasculature in early neurosyphilis, and additionally the brain and spinal cord parenchyma in late neurosyphilis...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29602529/neurosyphilis-as-a-cause-of-transverse-myelitis-in-a-teenage-girl
#9
Karen Kim Jo Yaphockun, Shannon Wai
BACKGROUND: Syphilis is a sexually transmitted infection that was nearly eradicated in 2001 but is now making a resurgence. It has a wide range of clinical manifestations depending on disease stage. Neurosyphilis is an infrequently seen infectious disease with central nervous system involvement that can occur in either early- or late-stage syphilis. The diagnosis of neurosyphilis is challenging, primarily because Treponema pallidum, the infecting organism, cannot be cultured in vitro...
March 27, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29566376/neurosyphilis-with-bilateral-optic-perineuritis-in-an-immunocompetent-patient
#10
Bruno Niemeyer, Bernardo Muniz, Lana Sayuri Makita, Edson Marchiori
No abstract text is available yet for this article.
March 22, 2018: European Neurology
https://www.readbyqxmd.com/read/29546365/postmortem-histopathologic-analysis-of-neurosyphilis-a-report-of-3-cases-with-clinicopathologic-correlations
#11
Chenhui Mao, Jing Gao, Liri Jin, Bin Peng, Yupu Guo
Neurosyphilis occurs in the late stage of systemic syphilis infection; early diagnosis and treatment are crucial to the prognosis. We review 3 autopsy cases with different subtypes of neurosyphilis, that is cases with meningovascular, general paresis, and a combination of the 2, respectively. We investigated the gross morphology and leptomeninges, vessels, cerebral cortex, white matter, brainstem, cerebellum, olfactory bulb and spinal cord microscopically. We found that meningovascular inflammation exists in both early and late phases of neurosyphilis, not only in the meningovascular subtype...
March 12, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29545440/dilated-tonic-pupils-with-tabes-dorsalis-in-neurosyphilis-as-first-manifestation-of-hiv-aids-a-video-report
#12
Antonio Jose Reyes, Kanterpersad Ramcharan, Samuel Aboh, Stanley Lawrence Giddings
No abstract text is available yet for this article.
March 15, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29528993/biomedical-research-priorities-for-modern-syphilis-clinical-management-diagnosis-and-vaccines-overview-and-commentary-for-unit-1
#13
Ellen N Kersh, Sheila A Lukehart
The first session at the 2016 Syphilis Summit provided an opportunity for laboratory researchers and clinicians to comment on gaps in biomedical knowledge and technologies. Predominant themes in the presentations and discussion included the need for optimization of existing diagnostic tests, commercial availability and FDA approval of nucleic acid amplification tests for primary and secondary syphilis, development of sensitive and specific new blood tests for diagnosis of active (vs. treated) syphilis infection, clarification of the best measures for adequacy of response to treatment, continued study of complications of syphilis including neuro- and ocular syphilis, and development of a safe and effective vaccine that will protect against transmission and complications of disseminated infection (including congenital and neurosyphilis)...
March 9, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29507143/teaching-neuroimages-gummatous-neurosyphilis-an-atypical-presentation-in-a-patient-with-hiv
#14
Helena Sá E Silva, Catarina O Paulo, Frederico Duarte, Ricardo C Abreu, Isabel Neves, Pedro Moniz
No abstract text is available yet for this article.
March 6, 2018: Neurology
https://www.readbyqxmd.com/read/29489672/the-clinical-and-laboratory-features-of-neurosyphilis-in-hiv-infected-patients-a-retrospective-study-in-92-patients
#15
Zhenyan Wang, Li Liu, Yin-Zhong Shen, Ren-Fang Zhang, Tang-Kai Qi, Yang Tang, Wei Song, Jun Chen, Hongzhou Lu
Neurosyphilis (NS) is an important component of central nervous system diseases among HIV-infected patients. However, its characteristics are not very clear. A retrospective analysis of clinical and laboratory findings was performed in 92 NS patients with HIV infection from a tertiary hospital in Shanghai, China. The patients had a median age of 38 years and a median CD4 count of 198 cells/μL. In all, 44.6% (41/92) were diagnosed as asymptomatic NS (ANS), 23.9% (22/92) as syphilitic meningitis, 17.4% (16/92) as cerebrovascular NS, and 14...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29479917/neurosyphilis-in-anglo-american-composers-and-jazz-musicians
#16
REVIEW
Darko Breitenfeld, Davor Kust, Tomislav Breitenfeld, Marin Prpić, Marko Lucijanić, Davor Zibar, Vedran Hostić, Maja Franceschi, Ante Bolanča
Syphilis is a sexually transmitted, systemic disease caused by the spirochete bacterium Treponema pallidum. The most common mechanism of transmission is sexual intercourse. Although there are several hypotheses, the exact origin of the disease remains unknown. Newly published evidence suggests that the hypothesis supporting the theory of the American origin of the disease is the valid one. Among 1500 analyzed pathographies of composers and musicians, data on ten Anglo-American composers and jazz musicians having suffered from neurosyphilis (tertiary stage of the disease) were extracted for this report...
September 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29478035/neurosyphilis-in-patients-with-hiv
#17
REVIEW
Emily Hobbs, Jaime H Vera, Michael Marks, Andrew William Barritt, Basil H Ridha, David Lawrence
Syphilis is a resurgent sexually transmitted infection in the UK that is disproportionately diagnosed in patients living with HIV, particularly in men who have sex with men. Syphilis appears to present differently in patients with HIV, particularly in those with severe immunosuppression. Progression to neurosyphilis is more common in HIV coinfection and can be asymptomatic, often for several years. The presentations of neurosyphilis vary but can include meningitis, meningovascular disease, general paresis and tabes dorsalis...
February 24, 2018: Practical Neurology
https://www.readbyqxmd.com/read/29432047/community-acquired-meningitis-in-hiv-infected-patients-in-the-united-states
#18
Karen J Vigil, Lucrecia Salazar, Rodrigo Hasbun
We conducted a retrospective study of 549 adults admitted with community-acquired meningitis (CAM) to several hospitals in New Orleans, LA and Houston, TX between 1999 and 2014 to characterize the current epidemiology, clinical manifestations, cerebrospinal fluid (CSF) characteristics, and outcomes of CAM between HIV-infected and uninfected patients and to identify risk factors for adverse outcomes in CAM. Bivariate analysis and logistic regression analysis were used to identify prognostic factors. A total of 1022 patients with CAM were screened...
February 2018: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/29420441/neurosyphilis-knowledge-gaps-and-controversies
#19
Susan Tuddenham, Khalil G Ghanem
After reaching a nadir at the turn of the century, syphilis rates in the United States have increased since 2000. Treponema pallidum may disseminate to the central nervous system within hours to days after inoculation. In this review, we focus on knowledge gaps and areas of controversy in neurosyphilis epidemiology, diagnosis, and management. Modern estimates of the prevalence of neurosyphilis are hindered by the lack of consistent reporting data and are based on relatively small retrospective cohort studies...
March 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29415349/management-of-neurosyphilis-time-for-a-new-approach
#20
Olivia C Smibert, Adam W J Jenney, Denis W Spelman
Given the long term sequelae of untreated neurosyphilis and insensitive tests to detect treponemes in the cerebrospinal fluid, questions regarding the utility of a lumbar puncture and cerebrospinal fluid analysis either to confirm or exclude neurosyphilis are raised.
February 2018: Internal Medicine Journal
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