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Li-Rong Lin, Dan-Hong Lin, Man-Li Tong, Li-Li Liu, Jin-Yi Fan, Xiao-Zhen Zhu, Kun Gao, Mei-Jun Chen, Wei-Hong Zheng, Hui-Lin Zhang, Shu-Lian Li, Hui-Ling Lin, Zhi-Feng Lin, Jian-Jun Niu, Tian-Ci Yang
BACKGROUND: Neurosyphilis (NS) is difficult to diagnose, especially in syphilis patients with negative cerebrospinal fluid (CSF) rapid plasma reagin (RPR) or Venereal Disease Research Laboratory (VDRL) tests. METHODS: We conducted a cross-sectional study and an analysis of macrophage migration inhibitory factor (MIF) in syphilitic patients to identify a novel marker for the diagnosis of NS, with a focus on probable NS (NS with negative VDRL/RPR tests). For this purpose, CSF and serum MIF concentrations were determined in 43 NS and 43 syphilis/non-NS (N-NS) patients at the Zhongshan Hospital of the Medical College of Xiamen University from July 2014 to June 2015...
October 14, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
N Dupin
Syphilis is back since the beginning of this century. The epidemic affects mainly men having sex with men with a high proportion of HIV-infected patients. The classification of syphilis distinguishes early syphilis where patients are contagious (primary, secondary and early latent of less than one year) and late syphilis where patients are not (or less) contagious (late latent of more than one year and tertiary). The clinical presentation of syphilis has not changed. However, we must insist on the early forms of neurosyphilis, notably ophthalmic syphilis often under-diagnosed, as it affects the treatment...
October 13, 2016: La Revue de Médecine Interne
M Pavan Kumar Reddy, Bharghav, N Nagaraj, Y J V Reddy, C N K Murthy
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Fan Wu, Jing-Ping Zhang, Qian-Qiu Wang
Treponema pallidum subspecies pallidum (T. pallidum), the pathogen of syphilis, can invade the central nervous system (CNS) and causes a series of severe diseases collectively termed neurosyphilis (NS).(1) Recently, there are increasing reports of NS cases, especially in HIV-infected syphilis patients.(2,3) Meanwhile, the misdiagnosis rate of NS is high, that of neurosyphilitic ischemic stroke was up to 80.95%.(4) This article is protected by copyright. All rights reserved.
September 29, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Cuini Wang, Kaiqi Wu, Qian Yu, Sufang Zhang, Zixiao Gao, Yudan Liu, Liyan Ni, Yuanyuan Cheng, Zhifang Guan, Mei Shi, Haikong Lu, Yongliang Lou, Pingyu Zhou
At present, diagnosis for neurosyphilis remains a major clinical challenge. Venereal Disease Research Laboratory (VDRL) titer of the cerebrospinal fluid (CSF) is suboptimally sensitive to diagnose neurosyphilis, which can be negative in neurosyphilis patients, especially in asymptomatic neurosyphilis patients. In the search for biomarkers of neurosyphilis, we investigated the chemokine profile in CSF of neurosyphilis patients and found that the concentrations of CXCL13, CXCL10 and CXCL8 were selectively elevated in neurosyphilis patients and correlated with CSF protein concentration and CSF-VDRL titer...
2016: Scientific Reports
Zachary D Zuschlag, Callie J Lalich, Edward B Short, Mark Hamner, David A Kahn
The concept that fevers can improve the condition of patients with certain medical and psychiatric diseases dates back to Hippocrates. Over the centuries, it has been observed that fevers and infectious agents have been beneficial for a broad spectrum of diseases, including neurologic conditions such as epilepsy and psychiatric illnesses including melancholy and psychosis. Interest in the concept of fever as a treatment for disease, termed pyrotherapy or pyretotherapy, peaked in the late 1800s and early 1900s thanks to the Nobel Prize winning work of Julius Wagner-Jauregg for his studies with malaria therapy for general paralysis of the insane, now more commonly referred to as neurosyphilis...
September 2016: Journal of Psychiatric Practice
Marcos Rosa Júnior, Thalita de Almeida Caçador, Claudia Biasutti, Augusto Meneghelli Galvão Gonçalves, Carlos Urbano Gonçalves Ferreira Júnior
No abstract text is available yet for this article.
September 20, 2016: Neurology
D Guedes de Carvalho, J Bouleau, M Pichenot, S Dive, L Duthoit, E Auxenfants, O Carpentier
BACKGROUND: The clinical polymorphism of syphilis leads to diagnostic issues. We report a case of secondary syphilis revealed by skin and mucosal erosions, and responsible for sensorineural hearing loss and asymptomatic papillitis. PATIENTS AND METHODS: A 55-year-old man presented oral and peri-anal erosions as the initial symptoms of secondary syphilis. He reported hypoacusis and a pure-tone audiogram revealed bilateral sensorineural hearing loss. Ophthalmological investigation revealed isolated right papillitis and superior temporal scotoma with blind-spot enlargement...
September 16, 2016: Annales de Dermatologie et de Vénéréologie
Cristian Vallejo, Yolanda Cifuentes
INTRODUCTION: Congenital syphilis is a preventable disease. However, the incidence in Colombia has increased and reached the figure of 3.28 cases per 1,000 live births in 2011.  OBJECTIVE: To characterize newborns with congenital syphilis and describe follow-up over 6 months following their diagnosis and treatment.  MATERIALS AND METHODS: Between August, 2011, and February, 2012, in Hospital La Victoria, sede Instituto Materno Infantil, newborns with congenital syphilis were identified and treated...
2016: Biomédica: Revista del Instituto Nacional de Salud
Clélia Vanhaecke, Philippe Grange, Nadjet Benhaddou, Philippe Blanche, Dominique Salmon, Perrine Parize, Olivier Lortholary, Eric Caumes, Isabelle Pelloux, Olivier Epaulard, Jérôme Guinard, Nicolas Dupin
BACKGROUND:  Syphilis remains a significant public health problem. We conducted a prospective study to define more precisely the clinical and biological characteristics of patients with neurosyphilis (NS), and we assessed the diagnostic value of nested polymerase chain reaction (PCR) testing for Treponema pallidum in cerebrospinal fluid (CSF) samples. METHODS:  From 2001 to 2013, we included 40 patients (90% men; 45% infected with human immunodeficiency virus) with NS, defined as syphilis with neurological and/or ophthalmological symptoms and CSF abnormalities...
November 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Daniel M Musher
No abstract text is available yet for this article.
November 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Riddhi Patira, Sarah Smith-Benjamin, Jijo J Wang
Syphilis has long been known as the great imitator. Its heterogeneity can manifest in the form of meningitis, space occupying gummas, vasculitis, strokes, cranial neuropathies, myelopathy, dementia, and seizures. The incidence has been rising with each year, mainly in men who have sex with men accounting for 83% of cases. With the coexistence of immunocompromised states, especially HIV (human immunodeficiency virus), the usually chronic and insidious course of tertiary neurosyphilis can be accelerated. Stroke can occur as a result of neurosyphilis in its meningovascular form, and the likelihood of this increases with HIV co-infection, especially in high-risk groups such as intravenous drug users and men who have sex with men...
August 10, 2016: International Journal of STD & AIDS
Li-Rong Lin, Man-Li Tong, Kun Gao, Xiao-Zhen Zhu, Jin-Yi Fan, Wei-Hong Zheng, Shu-Lian Li, Hui-Ling Lin, Li-Li Liu, Tian-Ci Yang
BACKGROUND: The diagnostic criteria for active infectious syphilis in the clinic are important matter of controversy and debate. So far, clinicians habitually do use the negative results of the nontreponemal and/or the specific antitreponemal IgM as the evidences of disease-free or active infection-free status. METHOD: We present a case study involving a patient who was admitted to Zhongshan Hospital because of cerebral infarct. Clinical examination indicated he had a history of latent syphilis with negative nontreponemal and specific antitreponemal IgM tests...
August 2016: Medicine (Baltimore)
Liis Sabre, Mark Braschinsky, Pille Taba
BACKGROUND: Neurosyphilis is defined as any involvement of the central nervous system by the bacterium Treponema pallidum. Movement disorders as manifestations of syphilis have been reported quite rarely. CASE PRESENTATION: We report a case of a 42-year-old Russian man living in Estonia with rapidly progressive dementia and movement disorders manifesting as myoclonus, cerebellar ataxia and parkinsonism. The mini mental state examination score was 12/30. After excluding different neurodegenerative causes, further diagnostic testing was consistent with neurosyphilis...
2016: BMC Research Notes
Abhay R Venkat, Jason Wenderoth, Louise Evans, Cecilia Cappelen-Smith
No abstract text is available yet for this article.
July 18, 2016: Medical Journal of Australia
R Steinberg
BACKGROUND: The composer Robert Schumann (1810-1856) spent the last two-and-a-half years of his life in the private psychiatric hospital in Endenich. His medical records emerged in 1991 and were published by Appel in 2006. METHODS: Daily entries by the physicians were analyzed concerning psychopathology and organic signs as well as the illness-related correspondence of the people closest to Schumann. RESULTS: The numerous entries reveal the treatment typical at that time for what was at first considered to be "melancholy with delusions": shielding from stimuli, physical procedures, and a dietary regimen...
July 25, 2016: Der Nervenarzt
Chenlong Yanga, Guang Lib, Jingyi Fangc, Hai Liua, Bao Yanga, Yulun Xua
BACKGROUND: Spinal syphilitic gumma is an unusual presentation of neurosyphilis, with a limited number of cases reported in the literature. Owing to its extreme rarity, the diagnosis and treatment of spinal syphilitic gumma as well as the relevant prognosis have not been outlined. CASE DESCRIPTION: We present a case of a 65-year-old female patient presenting with progressive sensorimotor disturbance of the extremities after a history of neck-shoulder-back pain. Serological tests revealed a presence of syphilis...
July 21, 2016: World Neurosurgery
Francesco Drago, Giulia Ciccarese, Francesco Broccolo, Giulia Sartoris, Paola Stura, Susanna Esposito, Alfredo Rebora, Aurora Parodi
The objective of this study was to evaluate the efficacy of an enhanced treatment regimen for syphilis with the addition of doxycycline and ceftriaxone to the conventional benzathine penicillin G (BPG) treatment. Sixty-nine syphilis patients were recruited and were randomly assigned to two groups: group 1 (38 patients) received standard therapy and group 2 (31 patients) received the enhanced therapy. All patients were followed-up for at least 12 months. Patients underwent physical examination and serology every 6 months as well as echocardiography and neurological examination every year...
June 2016: Journal of Global Antimicrobial Resistance
Monica I Lee, Annie W C Lee, Sean M Sumsion, Julie A Gorchynski
This case describes an emergency department (ED) presentation of ocular syphilis in a human immunodeficiency virus (HIV) infected patient. This is an unusual presentation of syphilis and one that emergency physicians should be aware of. The prevalence of syphilis has reached epidemic proportions since 2001 with occurrences primarily among men who have sex with men (MSM). This is a case of a 24-year-old male who presented to our ED with bilateral painless vision loss. The patient's history and ED workup were notable for MSM, positive rapid plasmin reagin (RPR) and HIV tests and fundus exam consistent with ocular syphilis, specifically uveitis...
July 2016: Western Journal of Emergency Medicine
Grace E Marx, Shireesha Dhanireddy, Jeanne M Marrazzo, Susan A Tuddenham, Anne M Rompalo, Peter A Leone, Charlotte A Gaydos, Cornelis A Rietmeijer
Ocular syphilis, a form of neurosyphilis, has been increasingly diagnosed in the United States. This case series summarizes the course of 6 patients recently diagnosed with ocular syphilis, emphasizing the varied sociodemographic factors and the wide range of symptoms and outcomes that are seen in patients with this disease.
August 2016: Sexually Transmitted Diseases
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