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https://www.readbyqxmd.com/read/27917762/revisiting-an-old-foe-the-face-of-psychosis-in-neurosyphilis
#1
Y Moolla, J Abdul
A delusional, agitated middle-aged man presented to hospital with a tenacious psychotic episode. Upon appropriate therapy for neurosyphilis, dramatic resolution of this brief episode ensued, prompting a literature review of psychosis associated with neurosyphilis.
December 1, 2016: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/27860537/use-of-lumbar-punctures-in-the-management-of-ocular-syphilis
#2
Ian Reekie, Yaviche Reddy
PURPOSE: Ocular syphilis has become rare in the developed world, but is a common presentation to ophthalmology departments in South Africa. We investigated the proportion of patients diagnosed with ocular syphilis who went on to receive lumbar punctures, and determined the fraction of these who had cerebrospinal fluid findings suggestive of neurosyphilis. We aimed to determine whether the use of lumbar punctures in ocular syphilis patients was beneficial in picking up cases of neurosyphilis...
November 18, 2016: Seminars in Ophthalmology
https://www.readbyqxmd.com/read/27833967/diagnosing-hiv-associated-cerebral-diseases-the-importance-of-neuropathology-in-understanding-hiv
#3
Ioan Alexandru Diaconu, LaurenŢiu MihăiŢă Stratan, Luciana Nichita, Victoria Aramă, Valentina Ruxandra Moroti Constantinescu, Alexandra Ioana Diaconu, Daniela Adriana Ion
The study aims to compare two aspects concerning the diagnosis of acquired immune deficiency syndrome (AIDS)-associated central nervous system (CNS) pathology (neuroAIDS): clinical diagnoses issued ante mortem with pathology results issued post mortem. The group of 39 human immunodeficiency virus (HIV)-positive patients was created over 23 years and is limited by marked heterogeneity. The enrolled cases were treated at the "Prof. Dr. Matei Bals" National Institute for Infectious Diseases, Bucharest, Romania, deceased due to AIDS-related complications and underwent brain necropsies performed in the Pathology Laboratory at the "Colentina" Clinical Hospital, Bucharest...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27810982/multifocal-neuropathic-arthropathy-in-patient-with-undiagnosed-neurosyphilis-a-case-report
#4
Chang-Wan Kim, Chang-Rack Lee
Although the prevalence of syphilis has decreased significantly, syphilis is still a common cause of neuropathic arthropathy. Tabetic arthropathy means progressive painless joint destruction that is related to neurosensory deficits caused by syphilis. In general, lower limb joints are involved and gradual swelling and instability of the involved joints are observed. Diagnosis of tabetic arthropathy is difficult as its clinical presentation is not specific and differential diagnosis is wide ranging. Hence, diagnosis of tabetic arthropathy requires clinical suspicion and an appropriate serological test...
November 2, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27789545/diagnosing-neurosyphilis-a-case-of-confusion
#5
Josephine Prynn, Andleeb Hussain, Andrew Winnett
A Pakistani man aged 60 years presented with personality change, aggression, paranoid delusions and sexual disinhibition while being treated for severe chest sepsis in intensive care. Collateral history confirmed that these personality changes had been developing over the course of the previous 2 years. He was found to have positive syphilis serology during a routine confusion screen, and the possibility of neurosyphilis was raised. Cerebrospinal fluid examination revealed elevated protein but negative syphilis testing...
October 27, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27779299/-neurosyphilis-in-the-21st-century-a-descriptive-study-in-a-tertiary-hospital-in-madrid
#6
R N Villar-Quiles, J Porta-Etessam
INTRODUCTION: Neurosyphilis can occur at any time following infection by Treponema pallidum and its incidence has increased over recent years. The epidemiological and clinical pattern has undergone a substantial change in the post-antibiotic era. AIMS: To describe and analyse the population of patients diagnosed with neurosyphilis at a tertiary hospital in Madrid from January to May 2015. PATIENTS AND METHODS: A retrospective analysis of the following data was performed: demographic, clinical, complementary tests -serology, cerebrospinal fluid (CSF), neuroimaging- and progression of 28 patients diagnosed between 2008 and 2015...
November 1, 2016: Revista de Neurologia
https://www.readbyqxmd.com/read/27761229/neurosyphilis-with-normal-pressure-hydrocephalus-and-dementia-paralytica-serial-clinical-laboratory-and-radiological-correlations-in-the-21st-century
#7
Kamille Abdool, Karan Seegobin, Kanterpersad Ramcharan, Adrian Alexander, Leandra Julien-Legen, Stanley Lawrence Giddings, Samuel Aboh, Fidel Rampersad
We report a case of a 46-year-old man presenting with a progressive cognitive decline, ataxic gait, urinary incontinence for 4 months and neuroimaging consistent with normal pressure hydrocephalus. The atypical presentation of a progressively worsening dysphasia and a right hemiparesis dismissed as a vascular event 1 month earlier associated with normal pressure hydrocephalus prompted further investigations confirming neurosyphilis also manifesting as dementia paralytica. Treatment using consensus guidelines led to resumption of activities of daily living...
September 30, 2016: Neurology International
https://www.readbyqxmd.com/read/27751728/macrophage-migration-inhibitory-factor-as-a-novel-cerebrospinal-fluid-marker-for-neurosyphilis-among-hiv-negative-patients
#8
Li-Rong Lin, Dan-Hong Lin, Man-Li Tong, Li-Li Liu, Jin-Yi Fan, Xiao-Zhen Zhu, Kun Gao, Mei-Jun Chen, Wei-Hong Zheng, Hui-Lin Zhang, Shu-Lian Li, Hui-Ling Lin, Zhi-Feng Lin, Jian-Jun Niu, Tian-Ci Yang
BACKGROUND: Neurosyphilis (NS) is difficult to diagnose, especially in syphilis patients with negative cerebrospinal fluid (CSF) rapid plasma reagin (RPR) or Venereal Disease Research Laboratory (VDRL) tests. METHODS: We conducted a cross-sectional study and an analysis of macrophage migration inhibitory factor (MIF) in syphilitic patients to identify a novel marker for the diagnosis of NS, with a focus on probable NS (NS with negative VDRL/RPR tests). For this purpose, CSF and serum MIF concentrations were determined in 43 NS and 43 syphilis/non-NS (N-NS) patients at the Zhongshan Hospital of the Medical College of Xiamen University from July 2014 to June 2015...
December 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27745937/-syphilis
#9
N Dupin
Syphilis is back since the beginning of this century. The epidemic affects mainly men having sex with men with a high proportion of HIV-infected patients. The classification of syphilis distinguishes early syphilis where patients are contagious (primary, secondary and early latent of less than one year) and late syphilis where patients are not (or less) contagious (late latent of more than one year and tertiary). The clinical presentation of syphilis has not changed. However, we must insist on the early forms of neurosyphilis, notably ophthalmic syphilis often under-diagnosed, as it affects the treatment...
October 13, 2016: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/27727813/psychiatric-presentation-of-neurosyphilis
#10
M Pavan Kumar Reddy, Bharghav, N Nagaraj, Y J V Reddy, C N K Murthy
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27684568/scanning-electron-microscopy-of-the-adhesion-of-treponema-pallidum-subspecies-pallidum-nichol-strain-to-human-brain-microvascular-endothelial-cells-in-vitro
#11
Fan Wu, Jing-Ping Zhang, Qian-Qiu Wang
Treponema pallidum subspecies pallidum (T. pallidum), the pathogen of syphilis, can invade the central nervous system (CNS) and causes a series of severe diseases collectively termed neurosyphilis (NS).(1) Recently, there are increasing reports of NS cases, especially in HIV-infected syphilis patients.(2,3) Meanwhile, the misdiagnosis rate of NS is high, that of neurosyphilitic ischemic stroke was up to 80.95%.(4) This article is protected by copyright. All rights reserved.
September 29, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27650493/cxcl13-cxcl10-and-cxcl8-as-potential-biomarkers-for-the-diagnosis-of-neurosyphilis-patients
#12
Cuini Wang, Kaiqi Wu, Qian Yu, Sufang Zhang, Zixiao Gao, Yudan Liu, Liyan Ni, Yuanyuan Cheng, Zhifang Guan, Mei Shi, Haikong Lu, Yongliang Lou, Pingyu Zhou
At present, diagnosis for neurosyphilis remains a major clinical challenge. Venereal Disease Research Laboratory (VDRL) titer of the cerebrospinal fluid (CSF) is suboptimally sensitive to diagnose neurosyphilis, which can be negative in neurosyphilis patients, especially in asymptomatic neurosyphilis patients. In the search for biomarkers of neurosyphilis, we investigated the chemokine profile in CSF of neurosyphilis patients and found that the concentrations of CXCL13, CXCL10 and CXCL8 were selectively elevated in neurosyphilis patients and correlated with CSF protein concentration and CSF-VDRL titer...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27648506/pyrotherapy-for-the-treatment-of-psychosis-in-the-21st-century-a-case-report-and-literature-review
#13
Zachary D Zuschlag, Callie J Lalich, Edward B Short, Mark Hamner, David A Kahn
The concept that fevers can improve the condition of patients with certain medical and psychiatric diseases dates back to Hippocrates. Over the centuries, it has been observed that fevers and infectious agents have been beneficial for a broad spectrum of diseases, including neurologic conditions such as epilepsy and psychiatric illnesses including melancholy and psychosis. Interest in the concept of fever as a treatment for disease, termed pyrotherapy or pyretotherapy, peaked in the late 1800s and early 1900s thanks to the Nobel Prize winning work of Julius Wagner-Jauregg for his studies with malaria therapy for general paralysis of the insane, now more commonly referred to as neurosyphilis...
September 2016: Journal of Psychiatric Practice
https://www.readbyqxmd.com/read/27647589/teaching-neuroimages-skull-and-dural-lesions-in-neurosyphilis
#14
Marcos Rosa Júnior, Thalita de Almeida Caçador, Claudia Biasutti, Augusto Meneghelli Galvão Gonçalves, Carlos Urbano Gonçalves Ferreira Júnior
No abstract text is available yet for this article.
September 20, 2016: Neurology
https://www.readbyqxmd.com/read/27646571/-skin-and-mucosal-erosions-revealing-secondary-syphilis-with-otologic-and-eye-disorders
#15
D Guedes de Carvalho, J Bouleau, M Pichenot, S Dive, L Duthoit, E Auxenfants, O Carpentier
BACKGROUND: The clinical polymorphism of syphilis leads to diagnostic issues. We report a case of secondary syphilis revealed by skin and mucosal erosions, and responsible for sensorineural hearing loss and asymptomatic papillitis. PATIENTS AND METHODS: A 55-year-old man presented oral and peri-anal erosions as the initial symptoms of secondary syphilis. He reported hypoacusis and a pure-tone audiogram revealed bilateral sensorineural hearing loss. Ophthalmological investigation revealed isolated right papillitis and superior temporal scotoma with blind-spot enlargement...
September 16, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27622443/characterization-and-six-month-follow-up-on-a-cohort-of-newborns-with-congenital-syphilis
#16
Cristian Vallejo, Yolanda Cifuentes
INTRODUCTION: Congenital syphilis is a preventable disease. However, the incidence in Colombia has increased and reached the figure of 3.28 cases per 1,000 live births in 2011.  OBJECTIVE: To characterize newborns with congenital syphilis and describe follow-up over 6 months following their diagnosis and treatment.  MATERIALS AND METHODS: Between August, 2011, and February, 2012, in Hospital La Victoria, sede Instituto Materno Infantil, newborns with congenital syphilis were identified and treated...
March 3, 2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27585981/clinical-and-biological-characteristics-of-40-patients-with-neurosyphilis-and-evaluation-of-treponema-pallidum-nested-polymerase-chain-reaction-in-cerebrospinal-fluid-samples
#17
Clélia Vanhaecke, Philippe Grange, Nadjet Benhaddou, Philippe Blanche, Dominique Salmon, Perrine Parize, Olivier Lortholary, Eric Caumes, Isabelle Pelloux, Olivier Epaulard, Jérôme Guinard, Nicolas Dupin
BACKGROUND:  Syphilis remains a significant public health problem. We conducted a prospective study to define more precisely the clinical and biological characteristics of patients with neurosyphilis (NS), and we assessed the diagnostic value of nested polymerase chain reaction (PCR) testing for Treponema pallidum in cerebrospinal fluid (CSF) samples. METHODS:  From 2001 to 2013, we included 40 patients (90% men; 45% infected with human immunodeficiency virus) with NS, defined as syphilis with neurological and/or ophthalmological symptoms and CSF abnormalities...
November 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27585980/editorial-commentary-polymerase-chain-reaction-for-the-tpp47-gene-a-new-test-for-neurosyphilis
#18
Daniel M Musher
No abstract text is available yet for this article.
November 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27510644/stroke-in-a-young-patient-with-neurosyphilis-and-hiv
#19
Riddhi Patira, Sarah Smith-Benjamin, Jijo J Wang
Syphilis has long been known as the great imitator. Its heterogeneity can manifest in the form of meningitis, space occupying gummas, vasculitis, strokes, cranial neuropathies, myelopathy, dementia, and seizures. The incidence has been rising with each year, mainly in men who have sex with men accounting for 83% of cases. With the coexistence of immunocompromised states, especially HIV (human immunodeficiency virus), the usually chronic and insidious course of tertiary neurosyphilis can be accelerated. Stroke can occur as a result of neurosyphilis in its meningovascular form, and the likelihood of this increases with HIV co-infection, especially in high-risk groups such as intravenous drug users and men who have sex with men...
August 10, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27495107/a-negative-nontreponemal-and-or-specific-antitreponemal-igm-test-does-not-exclude-active-infectious-syphilis-evidence-from-a-rabbit-infectivity-test-a-case-report
#20
Li-Rong Lin, Man-Li Tong, Kun Gao, Xiao-Zhen Zhu, Jin-Yi Fan, Wei-Hong Zheng, Shu-Lian Li, Hui-Ling Lin, Li-Li Liu, Tian-Ci Yang
BACKGROUND: The diagnostic criteria for active infectious syphilis in the clinic are important matter of controversy and debate. So far, clinicians habitually do use the negative results of the nontreponemal and/or the specific antitreponemal IgM as the evidences of disease-free or active infection-free status. METHOD: We present a case study involving a patient who was admitted to Zhongshan Hospital because of cerebral infarct. Clinical examination indicated he had a history of latent syphilis with negative nontreponemal and specific antitreponemal IgM tests...
August 2016: Medicine (Baltimore)
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