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https://www.readbyqxmd.com/read/28936074/syndromes-of-rapidly-progressive-cognitive-decline-our-experience
#1
Sadanandavalli Retnaswami Chandra, Lakshminarayanapuram Gopal Viswanathan, Anupama Ramakanth Pai, Rahul Wahatule, Suvarna Alladi
BACKGROUND: Dementias are fairly slowly progressive degenerative diseases of brain for which treatment options are very less and carry a lot of burden on family and society. A small percentage of them are rapidly progressive and mostly carry a different course outcome. However, there are no definite criteria other than the time line for these patients. AIMS: The aim of this was to identify and categorize the causes and course of rapidly progressive dementias seen in our center...
August 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28931218/aberrant-humoral-immune-responses-in-neurosyphilis-cxcl13-cxcr5-play-a-pivotal-role-for-b-cell-recruitment-to-the-cerebrospinal-fluid
#2
Qian Yu, Yuanyuan Cheng, Yuanyuan Wang, Cuini Wang, Haikong Lu, Zhifang Guan, Jian Huang, Weiming Gong, Mei Shi, Liyan Ni, Juan Wu, Ruirui Peng, Pingyu Zhou
Background: Previous studies documented that humoral immune responses participated in neurological damage in neurosyphilis patients. However, the mechanisms that trigger and maintain humoral immunity involved in neurosyphilis remain unknown. Methods: Using flow cytometry, expression of B cells was measured in neurosyphilis and non-neurosyphilis. Expression of immunoglobulin indices and chemokine ligand CXCL13 was detected by enzyme-linked immunosorbent assay. The migration and inhibition assays were evaluated by modified chamber assays...
September 1, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28928997/neurosyphilis-with-concomitant-cryptococcal-and-tuberculous-meningitis-in-a-patient-with-aids-report-of-a-unique-case
#3
Jose Armando Gonzales Zamora, Luis Alberto Espinoza, Rita N Nwanyanwu
Meningitis in individuals living with acquired immunodeficiency syndrome (AIDS) is most frequently infectious in origin and usually due to opportunistic infections. The most common pathogens are Cryptococcus neoformans and Mycobacterium tuberculosis. Treponema pallidum causes neurosyphilis and can complicate HIV infections at any time after the initial infection. Simultaneous infections of the central nervous system caused by these pathogens are very uncommon even in the setting of severe immunosuppression...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28923897/controlled-human-malaria-infection-applications-advances-and-challenges
#4
Danielle I Stanisic, James S McCarthy, Michael F Good
Controlled Human Malaria Infection (CHMI) entails deliberate infection with malaria parasites either by mosquito bite or direct injection of sporozoites or parasitised erythrocytes. When required, the resulting blood-stage infection is curtailed by the administration of anti-malarial drugs. Inducing a malaria infection via inoculation with infected blood was first used as a treatment (malariotherapy) for neurosyphilis in Europe and the United States in the early 1900s. More recently, CHMI has been applied to the fields of malaria vaccine and drug development where it is used to evaluate products in well-controlled early phase proof-of-concept clinical studies thus facilitating progression of only the most promising candidates for further evaluation in malaria-endemic areas...
September 18, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28876294/reported-cases-of-neurosyphilis-among-early-syphilis-cases-united-states-2009-to-2015
#5
Alex de Voux, Sarah Kidd, Elizabeth A Torrone
The surveillance of neurosyphilis, an uncommon but severe consequence of syphilis, is complex; surveillance classification of neurosyphilis requires a lumbar puncture and cerebrospinal fluid analysis. We examined the prevalence of reported neurosyphilis among primary, secondary, and early latent syphilis cases reported in the United States from 2009 to 2015. Overall, the prevalence of reported neurosyphilis from 2009 to 2015 was low (0.84%); however, this is likely an underestimate of the true burden in the United States...
August 10, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28874252/-neurosyphilis-as-differential-diagnosis-in-psychiatry
#6
Rikke Maria Nielsen, Elena Sadovina
A 46-year-old previously healthy man was referred to a psychiatric department after debuting with persecutory delusions. He had symptoms of Parkinson's disease as well as a significant impairment of memory and cognitive function. Neurological tests detected discrete balance and rigidity problems. Paraclinical tests were normal, and neurologists explained the symptoms as side effects to the antipsychotic medication. A lumbar puncture showed high concentrations of leukocytes and protein, and syphilis screening was positive...
September 4, 2017: Ugeskrift for Laeger
https://www.readbyqxmd.com/read/28867237/-neurosyphilis-a-retrospective-study-of-13-cases-at-strasbourg-university-hospital
#7
X Argemi, Y Hansmann, M Martin, N Lefebvre, N Douiri, D Christmann, J-B Chanson, A Sauer, S De Martino
OBJECTIVE: After a decade of constant decline, the number of syphilis cases has been steadily increasing since the 2000s, particularly in HIV infected patients. Neurosyphilis is a rare manifestation of this sexually transmitted disease for which we performed a retrospective study and analyzed clinical manifestations. PATIENTS AND METHODS: We reviewed retrospectively all the neurosyphilis cases admitted to Strasbourg University Hospital between 2004 and 2014. We included and analyzed 13 patients admitted during this period who met the diagnostic criteria for neurosyphilis...
August 31, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28859081/neurosyphilis-in-africa-a-systematic-review
#8
REVIEW
Michael Marks, Joseph N Jarvis, William Howlett, David C W Mabey
INTRODUCTION: Neurological involvement is one of the most important clinical manifestations of syphilis and neurological disease occurs in both early and late syphilis. The impact of HIV co-infection on clinical neurosyphilis remains unclear. The highest prevalence of both syphilis and HIV is in Africa. Therefore it might be expected that neurosyphilis would be an important and not uncommon manifestation of syphilis in Africa and frequently occur in association with HIV co-infection; yet few data are available on neurosyphilis in Africa...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28855625/serological-response-predicts-normalization-of-cerebrospinal-fluid-abnormalities-at-six-months-after-treatment-in-hiv-negative-neurosyphilis-patients
#9
Yao Xiao, Man-Li Tong, Li-Rong Lin, Li-Li Liu, Kun Gao, Mei-Jun Chen, Hui-Lin Zhang, Wei-Hong Zheng, Shu-Lian Li, Hui-Ling Lin, Zhi-Feng Lin, Tian-Ci Yang, Jian-Jun Niu
This study aimed to determine whether a serological response could predict the normalization of cerebrospinal fluid (CSF) abnormalities at 6 months after treatment in human immunodeficiency virus (HIV)-negative neurosyphilis patients. A total of 123 neurosyphilis patients were recruited at baseline, 58 of these patients undergoing treatment, repeated CSF examinations and serological tests for syphilis at 6 months after treatment were included in the follow-up study. Before treatment, the CSF rapid plasma reagin (RPR) titer, CSF Treponema pallidum particle agglutination (TPPA) titer, CSF leukocyte count, and CSF protein concentration were correlated with both serum RPR and TPPA titers...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28816862/unilateral-optic-neuritis-and-central-retinal-vasculitis-due-to-ocular-syphilis
#10
Murtaza S Khan, Dulanji K Kuruppu, Tanav A Popli, Ramana S Moorthy, Devin D Mackay
PURPOSE: Report a case of concurrent unilateral optic neuritis and central retinal artery occlusion as the presenting signs of syphilis. METHODS: A case report of a 22-year-old man with progressive unilateral vision loss. RESULTS: With no known previous history of syphilis, genital lesions, or other extraocular manifestations, the patient presented with pain with eye movements and decreased color vision. His vision dramatically worsened after a course of oral steroids...
August 14, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28768983/longitudinally-extensive-transverse-myelitis-and-optic-neuropathy-associated-with-syphilitic-meningomyelitis-and-human-immunodeficiency-virus-infection-a-case-report-and-review-of-the-literature
#11
Rie Tohge, Yuya Shinoto, Makio Takahashi
The incidence of co-infection with Treponema pallidum and human immunodeficiency virus (HIV) is increasing in developing and developed countries. The neurological complications of both infections occasionally occur simultaneously during a clinical course. We herein report the case of an HIV carrier with syphilitic meningomyelitis and subclinical optic neuropathy. The patient presumably had latent syphilis and slowly developed longitudinally extensive transverse myelitis (LETM). A cerebrospinal fluid examination confirmed the diagnosis of active neurosyphilis based on an elevated T...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28748060/a-case-of-attempted-bilateral-self-enucleation-in-a-patient-with-bipolar-disorder
#12
Hannah Muniz Castro, John Alvarez, Robert G Bota, Marc Yonkers, Jeremiah Tao
Attempted and completed self-enucleation, or removal of one's own eyes, is a rare but devastating form of self-mutilation behavior. It is often associated with psychiatric disorders, particularly schizophrenia, substance induced psychosis, and bipolar disorder. We report a case of a patient with a history of bipolar disorder who gouged his eyes bilaterally as an attempt to self-enucleate himself. On presentation, the patient was manic with both psychotic features of hyperreligous delusions and command auditory hallucinations of God telling him to take his eyes out...
March 22, 2017: Mental Illness
https://www.readbyqxmd.com/read/28739848/neurosyphilis-mimicking-autoimmune-encephalitis-in-a-52-year-old-man
#13
Adrian Budhram, Michael Silverman, Jorge G Burneo
No abstract text is available yet for this article.
July 24, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/28735562/diagnostic-and-therapeutic-knowledge-and-practices-in-the-management-of-congenital-syphilis-by-pediatricians-in-public-maternity-hospitals-in-brazil
#14
Raquel Rodrigues Dos Santos, Roberta Pereira Niquini, Francisco Inácio Bastos, Rosa Maria Soares Madeira Domingues
The study aimed to assess conformity with Brazil's standard protocol for diagnostic and therapeutic practices in the management of congenital syphilis by pediatricians in public maternity hospitals. A cross-sectional study was conducted in 2015 with 41 pediatricians working in all the public maternity hospitals in Teresina, the capital of Piauí State, Northeast Brazil, through self-completed questionnaires. The study assessed the conformity of knowledge and practices according to the Brazilian Ministry of Health protocols...
January 1, 2017: International Journal of Health Services: Planning, Administration, Evaluation
https://www.readbyqxmd.com/read/28609805/syphilis-in-pregnancy-and-congenital-syphilis-reality-in-a-portuguese-central-university-hospital
#15
Magda Magalhães, Lígia Basto, Ana Luísa Areia, Sofia Franco, Maria Eugénia Malheiro, Maria Eulália Afonso, Paulo Moura
Purpose To evaluate maternal-fetal surveillance and follow-up of infants at risk for congenital syphilis (CS). Methods Retrospective cohort study in a Portuguese Tertiary Referral Hospital. The main inclusion criterion was a positive syphilis serology. The study included all pregnant women that delivered in our hospital between January 2004 and December 2013. The neonates were classified according to their probability of infection based on the Centers for Disease Control and Prevention guidelines. Results Among the 27 pregnancies at risk for CS, 48...
June 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28596468/-the-unitary-psychosis-theory
#16
Hiroki Kikuyama, Tetsufumi Kanazawa, Seiichiro Tarutani, Tatsushi Okayama, Hiroshi Yoneda
Since E. Kraepelin isolated schizophrenia and bipolar disorder as heterogeneous diseases, attempts to categorize mental illnesses have continued to the DSM-5. Meanwhile, cases of psychosis occurring as a result of neurosyphilis have been reported. Whilst in some cases it is useful to divide mental illnesses, in others imposing such classifications may be not be feasible. Since 2008 numerous papers have been published showing that the same genes are related to an increased incidence of several psychiatric diseases including intellectual disorder, autism, ADHD, schizophrenia, bipolar disorder, and depression...
June 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28567314/subacute-hypophysitis-with-panhypopituitarism-as-first-presentation-of-hiv-and-syphilis-coinfection
#17
Rute Alves, Margarida França
Infection by Treponema pallidum still represents a clinical challenge due to its various forms of presentation. HIV coinfection added diversity and changed the natural history of syphilis as a systemic infection. We present a rare case of subacute hypophysitis and panhypopituitarism due to an early active neurosyphilis in a previously unknown HIV coinfected patient.
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28566179/acute-unilateral-peripheral-vestibulopathy-in-neurosyphilis
#18
Allison S Young, Antonia S Carroll, Miriam S Welgampola, Peter J McCluskey, Sebastian J van Hal, Elizabeth O Thompson, Juliet Burn, Michael J Fulham, G Michael Halmagyi
INTRODUCTION: Neurosyphilis producing basal meningitis presenting as sequential transient cranial nerve palsies was well recognized before the antibiotic era. OBJECTIVE: To report two patients presenting with acute unilateral peripheral vestibulopathy due to syphilitic basal meningitis. RESULTS: In Case 1 basal meningitis occurred early in the secondary phase of the infection, in Case 2 in the late latent phase. The diagnosis was not made immediately in either case; in Case 1 after previous presentation with increasing hearing loss and then with facial palsy and then a subsequent presentation with optic neuritis; in Case 2 after investigation for possible lymphoma...
July 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28538242/neuropsychiatric-features-of-neurosyphilis-frequency-relationship-with-the-severity-of-cognitive-impairment-and-comparison-with-alzheimer-disease
#19
Xiaomei Zhong, Haishan Shi, Le Hou, Ben Chen, Qi Peng, Xinru Chen, Zhangying Wu, Yanhua Wang, Naikeng Mai, Xingbing Huang, Yuping Ning
BACKGROUND: The pattern of neuropsychiatric features of patients with neurosyphilis and the impact of the severity of cognitive impairment on neuropsychiatric syndromes are unknown. OBJECTIVE: We aim to assess the neuropsychiatric features of patients with neurosyphilis, and compare the impact of the severity of cognitive impairment on the neuropsychiatric syndromes between neurosyphilis and Alzheimer disease (AD). METHODS: Neuropsychiatric symptoms and the degree of cognitive impairment were assessed in a case-control study of 91 neurosyphilis, 162 AD, 157 mild cognitive impairment, and 139 normal controls by the Neuropsychiatric Inventory (NPI) scale and Clinical Dementia Rating scale, respectively...
2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28532388/erratum-to-novel-predictors-of-neurosyphilis-among-hiv-negative-syphilis-patients-with-neurological-symptoms-an-observational-study
#20
Yao Xiao, Man-Li Tong, Li-Li Liu, Li-Rong Lin, Mei-Jun Chen, Hui-Lin Zhang, Wei-Hong Zheng, Shu-Lian Li, Hui-Ling Lin, Zhi-Feng Lin, Hui-Qin Xing, Jian-Jun Niu, Tian-Ci Yang
No abstract text is available yet for this article.
May 22, 2017: BMC Infectious Diseases
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