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https://www.readbyqxmd.com/read/29148855/effects-of-virtual-reality-based-training-with-bts-nirvana-on-functional-recovery-in-stroke-patients-preliminary-considerations
#1
Rosaria De Luca, Margherita Russo, Antonino Naro, Provvidenza Tomasello, Simona Leonardi, Floriana Santamaria, Latella Desireè, Alessia Bramanti, Giuseppe Silvestri, Placido Bramanti, Rocco Salvatore Calabrò
AIM OF THE STUDY: cognitive impairment occurs frequently in post-stroke patients. This study aimed to determine the effects of a virtual reality training (VRT) with BTs-Nirvana (BTsN) on the recovery of cognitive functions in stroke patients, using the Interactive-Semi-Immersive Program (I-SIP). MATERIALS AND METHODS: We enrolled 12 subjects (randomly divided into two groups: experimental group -EG; and control group -CG), who attended the Laboratory of Robotic and Cognitive Rehabilitation of IRCCS Neurolesi of Messina from January to June 2016...
November 17, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29147068/the-italian-version-of-the-five-word-test-a-simple-diagnostic-test-for-dementia-due-to-alzheimer-s-disease-in-routine-clinical-practice
#2
Luca Rozzini, Anna Ceraso, Marina Zanetti, Silvia Pelizzari, Evita Tomasoni, Vivian Accardo, Alessandro Padovani
Background: The five-word test (FWT) is a neuropsychological tool (derived from the Grober and Buschke paradigm), measuring hippocampal memory trace consolidation. The study aimed to validate the test for the Italian language and to verify its ability to discriminate patients affected by mild cognitive impairment and dementia due to Alzheimer's disease from healthy matches. Methods: 217 subjects (127 controls, 47 MCI due to AD, and 43 AD) underwent neuropsychological evaluation...
2017: Behavioural Neurology
https://www.readbyqxmd.com/read/29143869/peripheral-endocannabinoid-concentrations-are-not-associated-with-verbal-memory-impairment-during-mdma-intoxication
#3
E Haijen, M Farre, R de la Torre, A Pastor, E Olesti, N Pizarro, J G Ramaekers, K P C Kuypers
BACKGROUND: Preclinical data have suggested involvement of the endocannabinoid (eCB) system in MDMA-induced memory impairment. Clinical research has shown that blockade of the 5-HT2 receptor nulls memory impairment during MDMA intoxication. Interestingly, studies have demonstrated that the eCB and the 5-HT system interact. It was hypothesized that MDMA would cause an increase in eCB concentrations together with a decrease in memory performance, and that combining MDMA with a 5-HT2 receptor blocker ketanserin would lead to a counteraction of the MDMA effects on eCB concentrations and memory...
November 16, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29142396/antioxidant-and-cholinesterase-inhibitory-activities-of-ethyl-acetate-extract-of-terminalia-chebula-cell-free-in-vitro-and-in-silico-studies
#4
Mohamed Asik Rajmohamed, Suganthy Natarajan, Premkumar Palanisamy, Akbarsha Mohammad Abdulkader, Archunan Govindaraju
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder clinically characterized by memory loss and impaired cognitive function. Cholinergic enzyme deficiency and oxidative stress are the two major factors implicated in the pathogenesis of AD. The symptomatic treatment, as of now, is the use of cholinesterase inhibitors toward cholinergic "downturn." Therefore, there is a search for compounds that will be useful in focused therapies. There has been suggestion that Terminalia chebula fruit would be a potential source...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29141793/information-processing-deficits-as-a-driving-force-for-memory-impairment-in-ms-a-cross-sectional-study-of-memory-functions-and-mri-in-early-and-late-stage-ms
#5
Wolfgang Köhler, Martin Fischer, Peter Bublak, Jürgen H Faiss, Frank Hoffmann, Annett Kunkel, Michael Sailer, Matthias Schwab, Erhard Stadler, Uwe K Zettl, Iris-Katharina Penner
BACKGROUND: Memory impairment (MI) is a common symptom of MS. Previous studies were conflicting in respect to the possible existence of early MI and the role of hippocampal atrophy. The objective of this study was to investigate MI and structural MRI correlates in homogenous groups of early and late MS, controlling for a potential information-processing speed (IPS) deficit, and utilizing multiple memory test paradigms. METHODS: 152 individually matched subjects were recruited: early MS (EMS, N = 25, disease duration 1...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29133030/20-s-protopanaxadiol-ppd-alleviates-scopolamine-induced-memory-impairment-via-regulation-of-cholinergic-and-antioxidant-systems-and-expression-of-egr-1-c-fos-and-c-jun-in-mice
#6
Cong Lu, Liming Dong, Jingwei Lv, Yan Wang, Bei Fan, Fengzhong Wang, Xinmin Liu
20(S)-protopanaxadiol (PPD) possesses various biological properties, including anti-inflammatory, antitumor and anti-fatigue properties. Recent studies found that PPD functioned as a neurotrophic agent to ameliorate the sensory deficit caused by glutamate-induced excitotoxicity through its antioxidant effects and exhibited strong antidepressant-like effects in vivo. The objective of the present study was first to investigate the effect of PPD in scopolamine (SCOP)-induced memory deficit in mice and the potential mechanisms involved...
November 10, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29132782/midterm-outcomes-after-postoperative-delirium-on-cognition-and-mood-in-patients-after-cardiac-surgery
#7
Quyen Nguyen, Kelsey Uminski, Brett M Hiebert, Navdeep Tangri, Rakesh C Arora
OBJECTIVE: Delirium is a common neurologic complication after cardiac surgery. Our primary objective was to determine the impact of delirium on self-reported problems with midterm cognitive functioning and mood postcardiac surgery. METHODS: A single-center, prospective cohort study was conducted, enrolling 197 patients undergoing coronary artery bypass grafting or valve replacement. Baseline cognition and mood were assessed preoperatively in elective patients as a part of routine care using the Montreal Cognitive Assessment and Patient Health Questionnaire 9, respectively...
October 20, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29129545/predicting-progression-of-amnesic-mci-the-integration-of-episodic-memory-impairment-with-perfusion-spect
#8
Davide Quaranta, Guido Gainotti, Daniela Di Giuda, Maria Gabriella Vita, Fabrizio Cocciolillo, Giordano Lacidogna, Valeria Guglielmi, Carlo Masullo, Alessandro Giordano, Camillo Marra
The present study aimed at assessing if the ability to predict progression from amnesic Mild Cognitive Impairment (aMCI) to dementia is improved by considering the presence at the baseline of Single Photon Emission Computed Tomography (SPECT) perfusion abnormalities in addition to a defect of long term memory. The Episodic Memory Score (EMS), a global index which integrates results obtained in subtests of the Rey's Verbal Learning Test and the Rey-Osterrieth Figure recall, were taken into account to evaluate defects of long term memory...
October 24, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29126981/therapeutic-effect-of-adjunctive-n-acetyl-cysteine-nac-on-symptoms-of-chronic-schizophrenia-a-double-blind-randomized-clinical-trial
#9
Zahra Sepehrmanesh, Mahsa Heidary, Negar Akasheh, Hossein Akbari, Mahshid Heidary
BACKGROUND: Schizophrenia is one of the most disabling psychiatric syndromes with the prevalence of 1% in the general population. Despite availability of various antipsychotics, negative symptoms and cognitive impairment are difficult to treat. In addition antipsychotic monotherapy is not effective in most of these patients. Current evidence indicates the roles of glutamatergic system in this disorder. N-acetyl cysteine (NAC) also increases extracellular glutamate. This study was conducted to evaluate the clinical effects of oral NAC as an add-on to maintenance medication for the treatment of chronic schizophrenia...
November 7, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29126669/what-can-dti-tell-about-early-cognitive-impairment-differentiation-between-mci-subtypes-and-healthy-controls-by-diffusion-tensor-imaging
#10
Gyula Gyebnár, Ádám Szabó, Enikő Sirály, Zsuzsanna Fodor, Anna Sákovics, Pál Salacz, Zoltán Hidasi, Éva Csibri, Gábor Rudas, Lajos R Kozák, Gábor Csukly
Mild cognitive impairment (MCI) gained a lot of interest recently, especially that the conversion rate to Alzheimer Disease (AD) in the amnestic subtype (aMCI) is higher than in the non-amnestic subtype (naMCI). We aimed to determine whether and how diffusion-weighted MRI (DWI) using the diffusion tensor model (DTI) can differentiate MCI subtypes from healthy subjects. High resolution 3D T1W and DWI images of patients (aMCI, n = 18; naMCI, n = 20; according to Petersen criteria) and controls (n = 27) were acquired at 3T and processed using ExploreDTI and SPM...
October 31, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29125488/comparison-between-fcsrt-and-lassi-l-to-detect-early-stage-alzheimer-s-disease
#11
Jordi A Matias-Guiu, María Nieves Cabrera-Martín, Rosie E Curiel, María Valles-Salgado, Teresa Rognoni, Teresa Moreno-Ramos, José Luis Carreras, David A Loewenstein, Jorge Matías-Guiu
BACKGROUND: The Free and Cued Selective Reminding Test (FCSRT) is the most accurate test for the diagnosis of prodromal Alzheimer's disease (AD). Recently, a novel cognitive test, the Loewenstein-Acevedo Scale for Semantic Interference and Learning (LASSI-L), has been developed in order to provide an early diagnosis. OBJECTIVE: To compare the diagnostic accuracy of the FCSRT and the LASSI-L for the diagnosis of AD in its preclinical and prodromal stages using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) as a reference...
November 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29125199/evaluation-of-message-communication-strategy-combined-with-group-reminiscence-therapy-on-elders-with-mild-cognitive-impairment-in-long-term-care-facilities
#12
Huan-Huan Zhang, Peng-Cheng Liu, Jie Ying, Ying Shi, Shou-Qi Wang, Mei-Ling Zhang, Jiao Sun
OBJECTIVE: This study aims to evaluate combined effects of MESSAGE communication strategy and group reminiscence therapy (GRT) on elders with mild cognitive impairment (MCI) in long-term care facilities in Changchun, China. METHODS: This study is a nonrandomized controlled trial. Subjects included 60 elders with MCI. Participants were divided into intervention (MESSAGE communication strategy combined with GRT) and control groups (without any intervention). Primary outcomes comprised cognitive function and quality of life of elderly people, as measured by the Beijing version of the Montreal Cognitive Assessment and the Chinese (mainland) version of Short-Form 36 Health Survey assessment...
November 10, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29119540/discrimination-of-stroke-related-mild-cognitive-impairment-and-vascular-dementia-using-eeg-signal-analysis
#13
Noor Kamal Al-Qazzaz, Sawal Hamid Bin Mohd Ali, Siti Anom Ahmad, Mohd Shabiul Islam, Javier Escudero
Stroke survivors are more prone to developing cognitive impairment and dementia. Dementia detection is a challenge for supporting personalized healthcare. This study analyzes the electroencephalogram (EEG) background activity of 5 vascular dementia (VaD) patients, 15 stroke-related patients with mild cognitive impairment (MCI), and 15 control healthy subjects during a working memory (WM) task. The objective of this study is twofold. First, it aims to enhance the discrimination of VaD, stroke-related MCI patients, and control subjects using fuzzy neighborhood preserving analysis with QR-decomposition (FNPAQR); second, it aims to extract and investigate the spectral features that characterize the post-stroke dementia patients compared to the control subjects...
November 8, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29119313/the-effect-of-emotional-state-on-the-processing-of-morphosyntactic-and-semantic-reversal-anomalies-in-japanese-evidence-from-event-related-brain-potentials
#14
Masataka Yano, Yui Suzuki, Masatoshi Koizumi
The present study examined the locus responsible for the effect of emotional state on sentence processing in healthy native speakers of Japanese, using event-related brain potentials. The participants were induced into a happy, neutral, or sad mood and then subjected to electroencephalogram recording during which emotionally neutral sentences, including grammatical sentences (e.g. window-NOM close vi, 'The window closes.'), morphosyntactically-violated sentences (e.g. window-ACC close vi, Lit. 'Close the window...
November 8, 2017: Journal of Psycholinguistic Research
https://www.readbyqxmd.com/read/29113642/prefrontal-thalamic-anatomical-connectivity-and-executive-cognitive-function-in-schizophrenia
#15
Monica Giraldo-Chica, Baxter P Rogers, Stephen M Damon, Bennett A Landman, Neil D Woodward
BACKGROUND: Executive cognitive functions, including working memory, cognitive flexibility, and inhibition, are impaired in schizophrenia. Executive functions rely on coordinated information processing between the prefrontal cortex (PFC) and thalamus, particularly the mediodorsal nucleus. This raises the possibility that anatomical connectivity between the PFC and mediodorsal thalamus may be 1) reduced in schizophrenia and 2) related to deficits in executive function. The current investigation tested these hypotheses...
September 28, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29111025/orthostatic-hypotension-associated-with-executive-dysfunction-in-mild-cognitive-impairment
#16
Christian Bocti, François Pépin, Maxime Tétreault, Philippe Cossette, Francis Langlois, Hélène Imbeault, Nadia Duval, Guy Lacombe, Tamas Fulop
INTRODUCTION: Midlife hypertension is associated with dementia in longitudinal studies while chronic hypotension in the elderly is associated with dementia onset. Orthostatic hypotension could influence cognitive performance in the elderly. The objective of this study was to assess the relationship between orthostatic hypotension and cognitive functions. METHODS: Consecutive participants with complete neuropsychological evaluation from a Memory Clinic were included...
November 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29110615/effects-of-molecular-hydrogen-assessed-by-an-animal-model-and-a-randomized-clinical-study-on-mild-cognitive-impairment
#17
Kiyomi Nishimaki, Takashi Asada, Ikuroh Ohsawa, Etsuko Nakajima, Chiaki Ikejima, Takashi Yokota, Naomi Kamimura, Shigeo Ohta
BACKGROUND: Oxidative stress is one of the causative factors in the pathogenesis of neurodegenerative diseases including mild cognitive impairment (MCI) and dementia. We previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive antioxidant. OBJECTIVE: We assess the effects of drinking H2-water (water infused with H2) on oxidative stress model mice and subjects with MCI. METHODS: Transgenic mice expressing a dominant-negative form of aldehyde dehydrogenase 2 were used as a dementia model...
November 6, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/29108712/cognitive-functioning-in-dyskinetic-cerebral-palsy-its-relation-to-motor-function-communication-and-epilepsy
#18
Júlia Ballester-Plané, Olga Laporta-Hoyos, Alfons Macaya, Pilar Póo, Mar Meléndez-Plumed, Esther Toro-Tamargo, Francisca Gimeno, Ana Narberhaus, Dolors Segarra, Roser Pueyo
BACKGROUND: Cerebral palsy (CP) is a disorder of motor function often accompanied by cognitive impairment. There is a paucity of research focused on cognition in dyskinetic CP and on the potential effect of related factors. AIM: To describe the cognitive profile in dyskinetic CP and to assess its relationship with motor function and associated impairments. METHOD: Fifty-two subjects with dyskinetic CP (28 males, mean age 24 y 10 mo, SD 13 y) and 52 typically-developing controls (age- and gender-matched) completed a comprehensive neuropsychological assessment...
October 24, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29108479/time-perception-impairment-following-thalamic-stroke-a-case-study
#19
Joe Mole, Jill Winegardner, Donna Malley, Jessica Fish
Impaired time perception is considered to be a relatively unusual and poorly understood consequence of brain injury. This paper presents a case study of altered time perception in JB, a 50-year-old woman who in 2011 had a small thalamic stroke affecting the right anteromedian region. We report on her subjective experience and present results from studies of retrospective timing (i.e., estimating how much time has passed and the clock time) and prospective timing (i.e., producing and reproducing intervals). The results showed that relative to neurologically healthy and brain-injured controls, JB had impaired retrospective timing and impaired prospective time reproduction...
November 6, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/29107702/intra-nasal-dopamine-alleviates-cognitive-deficits-in-tgdisc1-rats-which-overexpress-the-human-disc1-gene
#20
An-Li Wang, Benedetta Fazari, Owen Y Chao, Susanne Nikolaus, Svenja V Trossbach, Carsten Korth, Fernando J Sialana, Gert Lubec, Joseph P Huston, Claudia Mattern, Maria Angelica de Souza Silva
The Disrupted-in-Schizophrenia 1 (DISC1) gene has been associated with mental illnesses such as major depression and schizophrenia. The transgenic DISC1 (tgDISC1) rat, which overexpresses the human DISC1 gene, is known to exhibit deficient dopamine (DA) homeostasis. To ascertain whether the DISC1 gene also impacts cognitive functions, 14-15 months old male tgDISC1 rats and wild-type controls were subjected to the novel object preference (NOP) test and the object-based attention test (OBAT) in order to assess short-term memory (1 h), long-term memory (24 h), and attention...
October 28, 2017: Neurobiology of Learning and Memory
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