keyword
https://read.qxmd.com/read/38534970/sars-cov-2-infection-is-an-independent-risk-factor-for-decompensation-in-cirrhosis-patients
#1
JOURNAL ARTICLE
Mark Ayoub, Julton Tomanguillo, Carol Faris, Nadeem Anwar, Harleen Chela, Ebubekir Daglilar
BACKGROUND: SARS-CoV-2 causes varied gastrointestinal symptoms. Cirrhosis patients face higher mortality rates from it, especially those with decompensated cirrhosis. This study examines SARS-CoV-2's impact on decompensation in previously compensated cirrhotic patients. METHODS: We analyzed the Global Collaborative Network, comprising 98 healthcare organizations across sixteen countries, using TriNetX's deidentified research database. Compensated cirrhosis patients were split into two groups: one with SARS-CoV-2-positive patients and another testing negative...
February 25, 2024: Diseases (Basel)
https://read.qxmd.com/read/38527522/acute-kidney-injury-in-patients-with-cirrhosis-acute-disease-quality-initiative-adqi-and-international-club-of-ascites-ica-joint-multidisciplinary-consensus-meeting
#2
REVIEW
Mitra K Nadim, John A Kellum, Lui Forni, Claire Francoz, Sumeet K Asrani, Marlies Ostermann, Andrew S Allegretti, Javier A Neyra, Jody C Olson, Salvatore Piano, Lisa B VanWagner, Elizabeth C Verna, Ayse Akcan-Arikan, Paolo Angeli, Justin M Belcher, Scott W Biggins, Akash Deep, Guadalupe Garcia-Tsao, Yuri S Genyk, Pere Gines, Patrick S Kamath, Sandra L Kane-Gill, Manish Kaushik, Nuttha Lumlertgul, Etienne Macedo, Rakhi Maiwall, Sebastian Marciano, Raimund H Pichler, Claudio Ronco, Puneeta Tandon, Juan-Carlos Q Velez, Ravindra L Mehta, François Durand
Patients with cirrhosis are prone to develop acute kidney injury (AKI), a complication associated with a markedly increased in-hospital morbidity and mortality, along with a risk of progression to chronic kidney disease. Whereas patients with cirrhosis are at increased risk of developing any phenotype of AKI, hepatorenal syndrome (HRS), a specific form of AKI (HRS-AKI) in patients with advanced cirrhosis and ascites, carries an especially high mortality risk. Early recognition of HRS-AKI is crucial since administration of splanchnic vasoconstrictors may reverse the AKI and serve as a bridge to liver transplantation, the only curative option...
March 23, 2024: Journal of Hepatology
https://read.qxmd.com/read/38526935/association-of-left-ventricular-diastolic-dysfunction-with-inflammatory-activity-renal-dysfunction-and-liver-related-mortality-in-patients-with-cirrhosis-and-ascites
#3
JOURNAL ARTICLE
Georgios Kalambokis, Maria Christaki, Ilias Tsiakas, Grigorios Despotis, Lampros Lakkas, Spiridon Tsiouris, Xanthi Xourgia, Georgios S Markopoulos, Lefkothea Dova, Haralampos Milionis
Left ventricular diastolic dysfunction (LVDD) is the predominant cardiac abnormality in cirrhosis. We investigated the association of LVDD with systemic inflammation and its impact on renal function, occurrence of hepatorenal syndrome (HRS) and survival in patients with cirrhosis and ascites. We prospectively enrolled 215 patients with cirrhosis and ascites. We evaluated the diagnosis and grading of LVDD by Doppler echocardiography, inflammatory markers, systemic hemodynamics, vasoactive factors, radioisotope-assessed renal function and blood flow, HRS development and liver-related mortality...
March 19, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38526023/review-article-recent-advances-in-ascites-and-acute-kidney-injury-management-in-cirrhosis
#4
REVIEW
Danielle Adebayo, Florence Wong
BACKGROUND: Better understanding of disease pathophysiology has led to advances in managing ascites and its associated complications including hepatorenal syndrome-acute kidney Injury (HRS-AKI), especially medicinal and interventional advances. AIM: To review the latest changes in the management of ascites and HRS-AKI. METHODS: A literature search was conducted in Pubmed, using the keywords cirrhosis, ascites, renal dysfunction, acute kidney injury, hepatorenal syndrome, beta-blockers, albumin, TIPS and vasoconstrictors, including only publications in English...
March 25, 2024: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/38525611/factors-influencing-in-hospital-mortality-for-salvage-percutaneous-transjugular-intrahepatic-portosystemic-shunting-in-cirrhotic-patients-with-recalcitrant-variceal-bleeding-after-failed-endoscopic-intervention
#5
JOURNAL ARTICLE
J E J Krige, E G Jonas, M Setshedi, S J Beningfield, U K Lotze, M M Bernon, S Burmeister, J C Kloppers
BACKGROUND: Endoscopic therapy is the first-line treatment of choice for control of acute variceal bleeding (AVB). In high-risk patients with persistent AVB despite pharmacological treatment and endoscopic intervention, percutaneous transjugular intrahepatic portosystemic shunting (TIPS) provides a minimally invasive salvage method to reduce portal pressure and control bleeding. OBJECTIVES: To evaluate factors influencing in-hospital mortality after salvage TIPS (sTIPS) in patients with exsanguinating variceal bleeding despite medical treatment and endoscopic intervention...
December 31, 2023: South African Medical Journal
https://read.qxmd.com/read/38524032/chilaiditi-s-syndrome-mimicking-crohn-s
#6
Sandres Aodish, Vincent Chang, Alexander Callow
Chilaiditi's sign (colonic interposition) is a rare anomaly due to an abnormally located portion of the colon that is interposed in between the liver and the diaphragm. This rare anomaly is often incidentally seen on chest or abdominal radiographs. Chilaiditi's radiographic sign is usually asymptomatic, whereas the medical condition accompanied by clinical symptoms is termed Chilaiditi's syndrome. Possible causes of the syndrome include a long and mobile colon, scarring of the liver (cirrhosis), ascites, long-standing lung disease, as well as laxity of the falciform ligament...
February 2024: Curēus
https://read.qxmd.com/read/38522854/comparison-of-glecaprevir-pibrentasvir-and-sofosbuvir-ledipasvir-in-patients-with-hepatitis-c-virus-genotype-1-and-2-in-south-korea
#7
JOURNAL ARTICLE
Hyun Deok Shin, Il Han Song, Sae Hwan Lee, Hong Soo Kim, Tae Hee Lee, Hyuk Soo Eun, Seok Hyun Kim, Byung Seok Lee, Hee Bok Chae, Seok Hwan Kim, Myung Joon Song, Soon Yeong Ko, Suk Bae Kim
BACKGROUND/AIMS: This study compared the effectiveness and safety of glecaprevir/pibrentasvir (GLE/PIB) and sofosbuvir/ledipasvir (SOF/LDV) in real-life clinical practice. METHODS: The data from genotype 1 or 2 chronic hepatitis C patients treated with GLE/PIB or sofosbuvir + ribavirin or SOF/LDV in South Korea were collected retrospectively. The analysis included the treatment completion rate, sustained virologic response at 12 weeks (SVR12) test rate, treatment effectiveness, and adverse events...
March 25, 2024: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://read.qxmd.com/read/38517600/study-of-prevalence-risk-factors-for-acute-kidney-injury-and-mortality-in-liver-cirrhosis-patients
#8
JOURNAL ARTICLE
Pooja Basthi Mohan, Shankar Prasad Nagaraju, Balaji Musunuri, Siddheesh Rajpurohit, Ganesh Bhat, Shiran Shetty
INTRODUCTION: Acute kidney injury (AKI) occurs frequently in patients with end-stage liver disease and cirrhosis and is associated with increased short-term mortality. This study aims to study the prevalence and risk factors associated with AKI development and mortality in cirrhosis of liver patients. METHODOLOGY: In the current prospective study, hospitalized patients with liver cirrhosis from October 2021 to March 2023 were recruited. Demographic, clinical, and laboratory data were collected, which included, the etiology of cirrhosis, comorbidities, severity of liver disease, and relevant biochemical parameters...
March 22, 2024: Irish Journal of Medical Science
https://read.qxmd.com/read/38512249/vibration-controlled-transient-elastography-scores-to-predict-liver-related-events-in-steatotic-liver-disease
#9
JOURNAL ARTICLE
Huapeng Lin, Hye Won Lee, Terry Cheuk-Fung Yip, Emmanuel Tsochatzis, Salvatore Petta, Elisabetta Bugianesi, Masato Yoneda, Ming-Hua Zheng, Hannes Hagström, Jérôme Boursier, José Luis Calleja, George Boon-Bee Goh, Wah-Kheong Chan, Rocio Gallego-Durán, Arun J Sanyal, Victor de Lédinghen, Philip N Newsome, Jian-Gao Fan, Laurent Castéra, Michelle Lai, Stephen A Harrison, Céline Fournier-Poizat, Grace Lai-Hung Wong, Grazia Pennisi, Angelo Armandi, Atsushi Nakajima, Wen-Yue Liu, Ying Shang, Marc de Saint-Loup, Elba Llop, Kevin Kim-Jun Teh, Carmen Lara-Romero, Amon Asgharpour, Sara Mahgoub, Mandy Sau-Wai Chan, Clemence M Canivet, Manuel Romero-Gomez, Seung Up Kim, Vincent Wai-Sun Wong
IMPORTANCE: Metabolic dysfunction-associated steatotic liver disease (MASLD) is currently the most common chronic liver disease worldwide. It is important to develop noninvasive tests to assess the disease severity and prognosis. OBJECTIVE: To study the prognostic implications of baseline levels and dynamic changes of the vibration-controlled transient elastography (VCTE)-based scores developed for the diagnosis of advanced fibrosis (Agile 3+) and cirrhosis (Agile 4) in patients with MASLD...
March 21, 2024: JAMA
https://read.qxmd.com/read/38504842/pulmonary-dysfunction-in-patients-with-cirrhosis-of-the-liver-a-study-of-pulmonary-function-tests-and-arterial-blood-gases
#10
JOURNAL ARTICLE
Bhumika Vaishnav, Dasaradha Ramu Barla, Pailla Ruchitha, Aniruddh N Wadivkar, Tushar Tonde, Saish Mondkar
BACKGROUND AND AIM: Respiratory complications in liver cirrhosis can occur due to various mechanisms, such as ascites causing restricted lung expansion and opening of intrapulmonary vascular shunts due to high portal pressures. We aimed to study the effects of the liver dysfunction on the lungs by evaluating arterial blood gas (ABG) and pulmonary function test (PFT) of all study subjects. SUBJECTS AND METHODS: A cross-sectional study was done between August 2020 and September 2022...
2024: International Journal of Applied and Basic Medical Research
https://read.qxmd.com/read/38486673/novel-nurse-led-early-postdischarge-clinic-is-associated-with-fewer-readmissions-and-lower-mortality-following-hospitalisation-with-decompensated-cirrhosis
#11
JOURNAL ARTICLE
Benjamin Giles, Kirsty Fancey, Karen Gamble, Zeshan Riaz, Joanna K Dowman, Andrew J Fowell, Richard J Aspinall
OBJECTIVE: Patients hospitalised with decompensated cirrhosis have high rates of early unplanned readmission. Many readmissions are avoidable with secondary preventative strategies, but patients are often readmitted prior to outpatient review. To address this, we established a novel, nurse-led early postdischarge (EPD) clinic delivering goal-directed care for cirrhosis complications and evaluated the impact. METHODS: Retrospective cohort study comparing outcomes in 78 patients seen in the EPD clinic with 91 phenotypically matched controls receiving standard, consultant hepatologist care...
March 2024: Frontline Gastroenterology
https://read.qxmd.com/read/38486668/quality-improvement-project-demonstrating-a-sustained-increase-in-the-assessment-and-sampling-of-ascites-for-hospitalised-patients-with-cirrhosis
#12
JOURNAL ARTICLE
Elizabeth L Herrle, Monica Thim, Matthew S Buttarazzi, Jenna Ptaschinski, Victoria Molina, Natalie Channell, Lesley B Gordon
OBJECTIVE: Using quality improvement techniques, we aimed to improve the rate of assessment and sampling of ascitic fluid for the purpose of diagnosing spontaneous bacterial peritonitis in patients with cirrhosis admitted to the hospitalist service of our institution. DESIGN/METHODS: Based on stakeholder needs assessment, we implemented interventions targeting provider knowledge, procedure workflows and clinical decision support. We analysed key metrics during preintervention (September-December 2020), intervention roll-out (January-April 2021), postintervention (May-September 2021) and sustainability (September-December 2022) periods for admissions of patients with cirrhosis to our hospitalist service at Maine Medical Center, a 700-bed tertiary-care academic hospital in Portland, Maine, USA...
March 2024: Frontline Gastroenterology
https://read.qxmd.com/read/38478755/safety-and-efficacy-of-off-label-bulevirtide-monotherapy-in-hdv-patients-with-decompensated-child-b-cirrhosis-a-real-world-case-series
#13
JOURNAL ARTICLE
Christopher Dietz-Fricke, Elisabetta Degasperi, Mathias Jachs, Benjamin Maasoumy, Florian P Reiter, Andreas Geier, Julia M Grottenthaler, Christoph P Berg, Kathrin Sprinzl, Stefan Zeuzem, Juliana Gödiker, Bernhard Schlevogt, Toni Herta, Johannes Wiegand, Roberta Soffredini, Heiner Wedemeyer, Katja Deterding, Thomas Reiberger, Pietro Lampertico
BACKGROUND AIMS: Chronic hepatitis D is the most debilitating form of viral hepatitis frequently progressing to cirrhosis and subsequent decompensation. However, the HDV entry inhibitor bulevirtide is only approved for antiviral treatment of patients with compensated disease. We aimed for the analysis of real-world data on the off-label use of bulevirtide in the setting of decompensated liver cirrhosis. APPROACH RESULTS: We conducted a retrospective study in HDV-patients with decompensated liver disease at German, Austrian and Italian centers...
March 13, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38474048/human-amniotic-msc-response-in-lps-stimulated-ascites-from-patients-with-cirrhosis-foxo1-gene-and-th17-activation-in-enhanced-antibacterial-activation
#14
JOURNAL ARTICLE
Mariangela Pampalone, Nicola Cuscino, Gioacchin Iannolo, Giandomenico Amico, Camillo Ricordi, Giampiero Vitale, Claudia Carcione, Salvatore Castelbuono, Simone Dario Scilabra, Claudia Coronnello, Salvatore Gruttadauria, Giada Pietrosi
Spontaneous bacterial peritonitis (SBP) is a severe complication in patients with decompensated liver cirrhosis and is commonly treated with broad spectrum antibiotics. However, the rise of antibiotic resistance requires alternative therapeutic strategies. As recently shown, human amnion-derived mesenchymal stem cells (hA-MSCs) are able, in vitro, to promote bacterial clearance and modulate the immune and inflammatory response in SBP. Our results highlight the upregulation of FOXO1, CXCL5, CXCL6, CCL20, and MAPK13 in hA-MSCs as well as the promotion of bacterial clearance, prompting a shift in the immune response toward a Th17 lymphocyte phenotype after 72 h treatment...
February 28, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38471790/health-related-quality-of-life-and-frailty-in-liver-cirrhosis
#15
JOURNAL ARTICLE
Yangyang Hui, Han Wang, Gaoyue Guo, Wanting Yang, Xiaoyu Wang, Binxin Cui, Xiaofei Fan, Chao Sun
BACKGROUND AND OBJECTIVES: There is limited evidence concerning the predictive value of health-related quality of life (HRQoL) on the presence of frailty in the context of cirrhosis. We aimed to elucidate the relationship between HRQoL and multidimensional frailty and to determine which HRQoL dimension independently impacted frail phenotype in our established cohort. METHODS: This was a prospective observational study by consecutively enrolling 355 patients with cirrhotic with decompensated signs in China...
March 12, 2024: BMJ Supportive & Palliative Care
https://read.qxmd.com/read/38465021/a-case-of-non-cirrhotic-portal-hypertension-with-antiphospholipid-syndrome
#16
Mili Shah, Razia Gill, Priya Hotwani, Hamsika Moparty, Naresh Kumar, Dhir Gala, Vikash Kumar
Nodular regenerative hyperplasia (NRH) and obliterative portal venopathy (OPV) are two causes of non-cirrhotic portal hypertension (NCPH), which is a vascular liver disease wherein clinical signs of portal hypertension (PHT), such as esophageal varices, ascites, and splenomegaly develop in the absence of cirrhosis and portal vein thrombosis. The etiology often remains unidentified, but herein we present the case of a 56-year-old male with NCPH and refractory ascites who underwent liver biopsy confirming NRH and OPV...
February 2024: Curēus
https://read.qxmd.com/read/38463355/development-of-a-new-cox-model-for-predicting-long-term-survival-in-hepatitis-cirrhosis-patients-underwent-transjugular-intrahepatic-portosystemic-shunts
#17
JOURNAL ARTICLE
Yi-Fan Lv, Bing Zhu, Ming-Ming Meng, Yi-Fan Wu, Cheng-Bin Dong, Yu Zhang, Bo-Wen Liu, Shao-Li You, Sa Lv, Yong-Ping Yang, Fu-Quan Liu
BACKGROUND: Transjugular intrahepatic portosystemic shunt (TIPS) placement is a procedure that can effectively treat complications of portal hypertension, such as variceal bleeding and refractory ascites. However, there have been no specific studies on predicting long-term survival after TIPS placement. AIM: To establish a model to predict long-term survival in patients with hepatitis cirrhosis after TIPS. METHODS: A retrospective analysis was conducted on a cohort of 224 patients who underwent TIPS implantation...
February 27, 2024: World Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38463353/correlation-between-serum-markers-and-transjugular-intrahepatic-portosystemic-shunt-prognosis-in-patients-with-cirrhotic-ascites
#18
JOURNAL ARTICLE
Xiao-Gang Hu, Xiao-Xian Yang, Jun Lu, Gang Li, Jian-Ji Dai, Jia-Min Wang, Yi Deng, Rui Feng
BACKGROUND: Individuals with refractory ascites in the context of liver cirrhosis typically face an adverse prognosis. The transjugular intrahepatic portosystemic shunt (TIPS) is an efficacious intervention, but there is a lack of reliable tools for postoperative prognosis assessment. Previously utilized clinical biochemical markers, such as the serum albumin concentration (Alb), sodium (Na+ ) concentration, and serum creatinine (Scr), have limited predictive value. Therefore, the quest for novel, specific biomarkers to evaluate the post-TIPS prognosis in patients with liver cirrhosis and refractory ascites holds significant practical importance...
February 27, 2024: World Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38460715/clinical-biochemical-and-histological-features-related-to-treatment-response-and-prognosis-in-autoimmune-hepatitis
#19
JOURNAL ARTICLE
Ludmila Resende Guedes, Guilherme Grossi Lopes Cançado, Bruno Campos Santos, Luma Dos Santos Jacomassi, Mateus Jorge Nardelli, Fernanda Maria Farage Osório, Luciana Costa Faria, Cláudia Alves Couto
INTRODUCTION AND OBJECTIVES: Autoimmune hepatitis (AIH) is a rare disease with a complex and not fully understood pathogenesis. Prognostic factors that might influence treatment response, relapse rates, and transplant-free survival are not well established. This study investigates clinical and biochemical markers associated with response to immunosuppression in patients with AIH. MATERIALS AND METHODS: This retrospective cohort study included 101 patients with AIH treated with immunosuppressants and followed at the Federal University of Minas Gerais, Brazil, from 1990 to 2018...
March 7, 2024: Annals of Hepatology
https://read.qxmd.com/read/38455627/co-incidence-of-covid-19-and-hepatocellular-carcinoma-during-pregnancy-double-punches-to-disease-severity-and-mortality
#20
JOURNAL ARTICLE
Azzaki Abubakar, Fauzi Yusuf, Sarah Firdausa, Desi Maghfirah, Andrie Gunawan, Cut M Yeni, Fitrah Sari
Hepatocellular carcinoma (HCC), a considerable leading cause of cancer-related deaths worldwide, is the most common primary liver cancer with poor prognosis and outcome. Many advances in prevention, screening, and new technologies in diagnostics and therapy have been achieved, but its incidence and mortality remain increasing. Co-infection of another viral disease in HCC patients with pregnancy might exacerbate the condition and double the mortality rate. The aim of this case report was to describe the co-infection of coronavirus disease 2019 (COVID-19) in an HCC patient during pregnancy...
December 2023: Narra J
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