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https://www.readbyqxmd.com/read/29474972/risk-factors-for-fecal-urgency-among-individuals-with-and-without-diarrhea-based-on-data-from-the-national-health-and-nutrition-examination-survey
#1
Vikram Rangan, Shuji Mitsuhashi, Prashant Singh, Sarah Ballou, William Hirsch, Thomas Sommers, Judy Nee, Johanna Iturrino, Anthony Lembo
BACKGROUND & AIMS: Fecal urgency is a common symptom among patients with gastrointestinal disorders, but can also occur in healthy individuals with normal bowel habits. There have been few studies of fecal urgency in the general population. We performed a cross-sectional analysis of data from the National Health and Nurition Examination Survey (NHANES) to analyze the prevalence of and risk factors for this symptom. METHODS: We analyzed data from 4,676 persons who completed the Bowel Health Questionnaire from the NHANES, from 2009 through 2010...
February 20, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29474804/use-of-fibers-in-childhood-constipation-treatment-systematic-review-with-meta-analysis
#2
REVIEW
Patricia P Mello, Diego A Eifer, Elza D Mello
OBJECTIVE: To gather current evidence on the use of fiber for constipation treatment in pediatric patients. SOURCE OF DATA: Systematic review with meta-analysis of studies identified through Pubmed, Embase, LILACS and Cochrane databases published up to 2016. INCLUSION CRITERIA: Randomized controlled trials; patients aged between 1 and 18 years and diagnosed with functional constipation receiving or not drug treatment for constipation; articles published in Portuguese, English, Spanish, French, and German in journals accessible to the researchers...
February 20, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29471989/the-relationship-between-intradialytic-nutrition-and-gastrointestinal-symptoms-using-a-modified-version-of-the-gastrointestinal-symptom-rating-scale
#3
Brandon M Kistler, Annabel Biruete, Karen Chapman-Novakofski, Kenneth R Wilund
OBJECTIVE: Intradialytic nutrition has been shown to improve nutritional status in maintenance hemodialysis (HD) patients but remains controversial due in part to concerns over hemodynamic stability and gastrointestinal (GI) distress. There are limited data on the relationship between intradialytic nutrition and GI symptoms, possibly due to the lack of a validated tool. Therefore, we intended to validate a questionnaire to measure GI symptoms associated with a single HD treatment and determine the relationship between intradialytic nutrition and GI symptoms...
March 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29471018/rotenone-induces-gastrointestinal-pathology-and-microbiota-alterations-in-a-rat-model-of-parkinson-s-disease
#4
Michaela E Johnson, Andrea Stringer, Larisa Bobrovskaya
While people are often aware of the motor symptoms in Parkinson's disease (PD), few know of the many non-motor symptoms, which patients report have a greater impact on their quality of life. Gastrointestinal (GI) dysfunction is one of the most common non-motor symptoms, which can occur at any stage of PD, even years prior to diagnosis, and can affect all sections along the GI tract causing a range of symptoms including drooling, gastroparesis and constipation. We have investigated whether a neurotoxin model of PD- rotenone, a mitochondrial complex I inhibitor, is capable of reproducing the GI dysfunction seen clinically...
February 19, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/29470731/sacral-neuromodulation-versus-personalized-conservative-treatment-in-patients-with-idiopathic-slow-transit-constipation-study-protocol-of-the-no-2-trial-a-multicenter-open-label-randomized-controlled-trial-and-cost-effectiveness-analysis
#5
S C M Heemskerk, A H Rotteveel, M A Benninga, C I M Baeten, A A M Masclee, J Melenhorst, S M J van Kuijk, C D Dirksen, S O Breukink
PURPOSE: The evidence regarding the (cost-)effectiveness of sacral neuromodulation (SNM) in patients with therapy-resistant idiopathic slow-transit constipation is of suboptimal quality. The Dutch Ministry of Health, Welfare and Sports has granted conditional reimbursement for SNM treatment. The objective is to assess the effectiveness, cost-effectiveness, and budget impact of SNM compared to personalized conservative treatment (PCT) in patients with idiopathic slow-transit constipation refractory to conservative treatment...
February 22, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29470689/the-nutritional-and-health-attributes-of-kiwifruit-a-review
#6
REVIEW
David P Richardson, Juliet Ansell, Lynley N Drummond
PURPOSE: To describe the nutritional and health attributes of kiwifruit and the benefits relating to improved nutritional status, digestive, immune and metabolic health. The review includes a brief history of green and gold varieties of kiwifruit from an ornamental curiosity from China in the 19th century to a crop of international economic importance in the 21st century; comparative data on their nutritional composition, particularly the high and distinctive amount of vitamin C; and an update on the latest available scientific evidence from well-designed and executed human studies on the multiple beneficial physiological effects...
February 22, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29470292/rectal-picking-masquerading-as-inflammatory-bowel-disease-in-prader-willi-syndrome
#7
Parisa Salehi, Dale Lee, Lusine Ambartsumyan, Natalie Sikka, Ann O Scheimann
Prader-Willi syndrome (PWS) is a genetic syndrome in which individuals have multisystem medical challenges. Gastroenterological difficulties in the syndrome include decreased vomiting, constipation, delayed gastric emptying, delayed colonic transit, dysphagia, increased choking, and increased risk of gastric dilation and rupture. In addition, self-injurious behavior such as rectal picking may be present and severe enough to lead to rectal ulceration and bleeding. Many patients have extensive gastroenterological workup and treatment before their ultimate diagnosis of severe rectal picking...
February 21, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29468835/gastrointestinal-symptoms-in-patients-receiving-dialysis-a-systematic-review
#8
REVIEW
J Zuvela, C Trimingham, R Le Leu, R Faull, P Clayton, S Jesudason, A Meade
AIM: To describe the prevalence of all Gastrointestinal (GI) symptoms reported by dialysis patients, as well as the tools being used for diagnosis. BACKGROUND: GI symptoms are commonly reported in patients having haemodialysis (HD) and peritoneal dialysis (PD), but there are multiple definitions and assessment tools reported in the literature. METHODS: A comprehensive systematic review was undertaken using five databases (Embase, Medline, CINAHL, Psycinfo and Web of Science) between 1996 and 2017...
February 22, 2018: Nephrology
https://www.readbyqxmd.com/read/29467147/alectinib-for-advanced-alk-positive-non-small-cell-lung-cancer
#9
REVIEW
Ashley C Ly, Jacqueline L Olin, Morgan B Smith
PURPOSE: The pharmacology, pharmacokinetics, clinical efficacy, safety and tolerability, dosage and administration, and place in therapy of alectinib for treatment of patients with non-small-cell lung cancer (NSCLC) are reviewed. SUMMARY: In patients with NSCLC driven by mutations of ALK , the gene coding for anaplastic lymphoma kinase (ALK), treatment with the ALK inhibitor crizotinib has been found to provide median progression-free survival (PFS) of 10.9 months; however, therapeutic failures and tumor progression to brain metastases are common with crizotinib use, prompting research to find more potent and tolerable ALK inhibitors that target major oncogenic drivers of NSCLC...
February 21, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29466417/epinephrine-modulates-na-k-atpase-activity-in-caco-2-cells-via-src-p38mapk-erk-and-pge2
#10
Layla El Moussawi, Mohamed Chakkour, Sawsan I Kreydiyyeh
Epinephrine, a key stress hormone, is known to affect ion transport in the colon. Stress has been associated with alterations in colonic functions leading to changes in water movements manifested as diarrhea or constipation. Colonic water movement is driven by the Na+-gradient created by the Na+/K+-ATPase. Whether epinephrine acts via an effect on the Na+/K+-ATPase hasn't been studied before. The aim of this work was to investigate the effect of epinephrine on the Na+/K+-ATPase and to elucidate the signaling pathway involved using CaCo-2 cells as a model...
2018: PloS One
https://www.readbyqxmd.com/read/29464583/intestinal-involvement-in-systemic-sclerosis-a-clinical-review
#11
REVIEW
Lazaros I Sakkas, Theodora Simopoulou, Dimitrios Daoussis, Stamatis-Nick Liossis, Spyros Potamianos
Systemic sclerosis (SSc) is a chronic systemic disease characterized by microvasculopathy, autoantibodies, and extensive fibrosis. Intestinal involvement is frequent in SSc and represents a significant cause of morbidity. The pathogenesis of intestinal involvement includes vascular damage, nerve dysfunction, smooth muscle atrophy, and fibrosis, causing hypomotility, which leads to small intestinal bacterial overgrowth (SIBO), malabsorption, malnutrition, diarrhea, pseudo-obstruction, constipation, pneumatosis intestinalis, and fecal incontinence...
February 21, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29464374/heterogeneous-pattern-of-autonomic-dysfunction-in-parkinson-s-disease
#12
Laurène Leclair-Visonneau, Laurent Magy, Christelle Volteau, Thomas Clairembault, Séverine Le Dily, Cécile Préterre, Arnaud Peyre, Philippe Damier, Michel Neunlist, Yann Péréon, Pascal Derkinderen
Dysautonomic symptoms are frequent non-motor complaints in patients with Parkinson's disease. Numerous neuropathological studies have shown that Lewy bodies and neurites, the pathological hallmarks of Parkinson's disease, are widely distributed throughout the peripheral autonomic nervous systems and across end organs. However, few investigations integrally explored the symptoms and physiology of dysautonomia in Parkinson's disease. We, therefore, performed a comprehensive evaluation of the autonomic function in a prospective group of 45 patients with idiopathic Parkinson's disease...
February 20, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29464227/childhood-constipation
#13
Michelle Waterham, Jonathan Kaufman, Susan Gibb
BACKGROUND: Constipation is best defined as difficulty passing stools that may be infrequent (≤2 per week), painful and associated with stool retention. Childhood constipation is common, with a prevalence of 3-30% worldwide. Most constipation in children is functional and related to behavioural withholding after an unpleasant stool event. Successful diagnosis and management can occur in primary care, and specialist referral is only needed for refractory cases or concerns regarding organic pathology...
December 2017: Australian Family Physician
https://www.readbyqxmd.com/read/29459985/when-do-%C3%AE-synucleinopathies-start-an-epidemiological-timeline-a-review
#14
Rodolfo Savica, Boeve F Bradley, Michelle M Mielke
Importance: This article reviews the epidemiological evidence of features of α-synucleinopathies that precede clinical onset of disease, proposes a clinical timeline, and attempts to define the different premotor and clinical phenotypes associated with α-synucleinopathies. Observations: The pathological hallmarks of the α-synucleinopathies (Parkinson disease, Parkinson disease dementia, dementia with Lewy bodies, and multisystem atrophy) begin years before a clinical diagnosis...
February 19, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29459618/irritable-bowel-syndrome-is-it-rare-in-children
#15
M Rukunuzzaman, A B Karim, M Nurullah, M W Mazumder, K Sultana, F Hussain, F Sultana
Irritable bowel syndrome (IBS) is one of the most common and best studied disorders among the group of functional gastrointestinal disorders. It is a functional bowel disorder in which abdominal pain or discomfort is associated with defecation or a change in bowel habit. Visceral hypersensitivity and increased GIT motility are the main patho-physiological mechanism for developing IBS. IBS present with diarrhea and constipation or both. Investigation is least needed for diagnosis of IBS rather done to exclude differential diagnosis...
January 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29458938/effects-of-tongue-cleaning-on-ayurvedic-digestive-power-and-oral-health-related-quality-of-life-a-randomized-cross-over-study
#16
A Tokinobu, T Yorifuji, M Sasai, H Doi, T Tsuda
OBJECTIVES: The effect of tongue cleaning on digestive power is mentioned in Ayurvedic information sources. However, no study has yet evaluated this. We aimed to evaluate the effects of tongue cleaning on digestive power from Ayurvedic viewpoint, and on oral health-related quality of life (OHRQoL) in healthy adults. DESIGN: Randomized cross-over. INTERVENTIONS: We recruited healthy adults aged 20-60 years. After randomization, the immediate intervention group started tongue cleaning with a tongue scraper every morning for 4 weeks, and then waited for 4 weeks...
February 2018: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29456933/pediatricians-lack-knowledge-for-the-diagnosis-and-management-of-functional-constipation-in-children-over-6-mo-of-age
#17
Ariani Widodo, Badriul Hegar, Yvan Vandenplas
AIM: To assess the knowledge of general pediatricians througout Indonesia about the diagnosis and treatment of childhood constipation. METHODS: A comprehensive questionnaire was distributed to general pediatricians from several teaching hospitals and government hospitals all over Indonesia. RESULTS: Data were obtained from 100 pediatricians, with a mean of 78.34 ± 18.00 mo clinical practice, from 20 cities throughout Indonesia. Suspicion of constipation in a child over 6 mo of age arises when the child presents with a decreased frequency of bowel movements (according to 87% of participants) with a mean of one bowel movement per 3...
February 8, 2018: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/29455410/can-patients-with-symptomatic-tarlov-cysts-be-differentiated-from-patients-with-specific-low-back-pain-based-on-comprehensive-history-taking
#18
Maria Anna Hulens, Wim Dankaerts, Ricky Rasschaert, Frans Bruyninckx, Marie-Laure Willaert, Charlotte Vereecke, Greet Vansant
BACKGROUND: Tarlov cysts (TCs) are expanded nerve root sheaths that occur near the dorsal root ganglion and result from increased intraspinal hydrostatic pressure. TCs most frequently affect the lumbosacral plexus and therefore may cause specific symptoms such as perineal pain and neurogenic bladder, bowel, and sphincter problems. It has been estimated that 1% of the population has symptomatic Tarlov cysts (STCs). However, STCs appear to be underdiagnosed, with the pain reported by patients commonly attributed to degenerative alterations seen on MRI...
February 17, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29454662/fecal-markers-of-intestinal-inflammation-and-intestinal-permeability-are-elevated-in-parkinson-s-disease
#19
Andreas Schwiertz, Jörg Spiegel, Ulrich Dillmann, David Grundmann, Jan Bürmann, Klaus Faßbender, Karl-Herbert Schäfer, Marcus M Unger
BACKGROUND/OBJECTIVE: Intestinal inflammation and increased intestinal permeability (both possibly fueled by dysbiosis) have been suggested to be implicated in the multifactorial pathogenesis of Parkinson's disease (PD). The objective of the current study was to investigate whether fecal markers of inflammation and impaired intestinal barrier function corroborate this pathogenic aspect of PD. METHODS: In a case-control study, we quantitatively analyzed established fecal markers of intestinal inflammation (calprotectin and lactoferrin) and fecal markers of intestinal permeability (alpha-1-antitrypsin and zonulin) in PD patients (n = 34) and controls (n = 28, group-matched for age) by enzyme-linked immunosorbent assay...
February 12, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29453699/unusual-intestinal-involvement-by-paracoccidioidomycosis-diagnosed-after-oral-manifestation
#20
Rodrigo Neves-Silva, Patrícia Maria Fernandes, Alan Roger Santos-Silva, Pablo Agustin Vargas, Ricardo de Souza Cavalcante, Marcio Ajudarte Lopes
Paracoccidioidomycosis is a common deep fungus infection in South America, particularly in Brazil. It is acquired through inhalation and primary involvement of lungs. Subsequently, dissemination may occur and oral mucosa is frequently affected and actually, in most of the cases the diagnosis is established because of the oral lesions. Thus, the role of the dentist is fundamental to correct diagnosis. However, the involvement of intestine is rarely reported. The current case describes a 36-year-old man who presented abdominal pain and intestinal constipation, being suspected and then confirmed as paracoccidioidomycosis after already be diagnosed with this disease by a dentist through oral manifestations...
February 16, 2018: Mycopathologia
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