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https://www.readbyqxmd.com/read/29161802/the-impact-of-surgical-timing-on-pathologic-tumor-response-after-short-course-and-long-course-preoperative-chemoradiation-for-locally-advanced-rectal-adenocarcinoma
#1
Sea-Won Lee, Jong Hoon Lee, In Kyu Lee, Seong Taek Oh, Dae Yong Kim, Tae Hyun Kim, Jae Hwan Oh, Ji Yeon Baek, Hee Jin Chang, Hee Chul Park, Hee Cheol Kim, Eui Kyu Chie, Taek-Keun Nam, Hong Seok Jang
Purpose: A pooled analysis of multi-institutional trials was performed to analyze the effect of surgical timing on tumor response by comparing short course concurrent chemoradiotherapy (CCRT) with long course CCRT followed by delayed surgery in locally advanced rectal cancer. Materials and Methods: Three hundred patients with cT3-4N0-2 rectal adenocarcinoma were included. Long course patients from KROG 14-12 (n=150) were matched 1:1 to 150 short course patients from KROG 10-01 (NCT01129700) and KROG 11-02 (NCT01431599) according to stage, age, and other risk factors...
November 21, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29161783/cancer-treatment-and-management-for-elderly-patients-80-years-of-age-or-older-with-malignant-solid-tumors
#2
Mao Matsubayashi, Fumihiro Oshita, Natsuki Kawata, Takafumi Yanagibashi, Satoshi Tanaka, Yoshiteru Hao, Yuichi Kurakami, Keisuke Iwabuchi, Yohsuke Kunishi, Mitsuyasu Ohta, Yuki Nakamura, Kohichiro Yoshie
We retrospectively analyzed the backgrounds, treatment and nursing care for 96 patients aged 80 years or more with malignant tumors. Twenty of them were hospitalized on an emergency basis. Sixty patients were male and 36 were female, with a median age of 83 years (range: 80-94 years). Twenty-seven had a PS of 3 or 4, and 41 were rated as not independent based on analysis of autonomy at hospitalization. Forty-seven patients had clinical stage III or IV malignancies. The proportions of patients with disease complications were 33...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29161775/the-influence-of-different-peptide-combinations-to-increase-the-immunogenicity-of-the-gonadotrophin-releasing-hormone-vaccine-for-prostate-cancer-treatment
#3
Franklin Fuentes Aguilar, Jesús Junco Barranco, Lesvia Calzada Aguilera, Eddy Bover Fuentes, Jose André Serradelo Leal, Eduardo Hernández López, Eulogio Pimentel Vázquez, Roberto Basulto Baker, Osvaldo Reyes Acosta, Hilda Garay Pérez, Gerardo Guillén Nieto
Purpose: Therapeutic vaccines, specifically the Gonadotrophin Releasing Hormone (GnRH) vaccine, are considered an additional therapeutic option for advanced stage prostate cancer. Our work showed amplification of the immune response when combining two peptides with and without the Very Small Size Proteoliposomes (VSSP). VSSP is a potent adjuvant for dendritic cells activation and Th1 differentiation. as enhanced immune response. Methods: The test was carried out in Copenhagen rats as animal model...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29161448/prenatal-famine-exposure-adulthood-obesity-patterns-and-risk-of-type-2-diabetes
#4
Ruogu Meng, Jun Lv, Canqing Yu, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Hui Zhang, Xiaofang Chen, Junshi Chen, Zhengming Chen, Lu Qi, Liming Li
Background: Prenatal exposure to famine and adulthood obesity have been independently related to the risk of type 2 diabetes; however, little is known about the joint effects of these risk factors at different stages of life on adulthood diabetes risk. Methods: The analysis included 88 830 participants of the China Kadoorie Biobank, who were born around the time of the Chinese Great Famine and without diabetes, cardiovascular diseases, or cancer at baseline. We defined famine exposure subgroups as nonexposed (born between 1 October 1962 and 30 September 964), fetal-exposed (born between 1 October 1959 and 30 September 1961) and early-childhood exposed (born between 1 October 1956 and 30 September 1958)...
November 17, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29161337/age-at-diagnosis-and-prostate-cancer-treatment-and-prognosis-a-population-based-cohort-study
#5
A Pettersson, D Robinson, H Garmo, L Holmberg, P Stattin
Background: Old age at prostate cancer diagnosis has been associated with poor prognosis in several studies. We aimed to investigate the association between age at diagnosis and prognosis, and if it is independent of tumor characteristics, primary treatment, year of diagnosis, mode of detection and comorbidity. Patients and methods: We conducted a nation-wide cohort study including 121,392 Swedish men aged 55-95 years in Prostate Cancer data Base Sweden (PCBaSe) 3...
November 17, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29161283/prognostic-significance-of-promoter-dna-hypermethylation-of-the-cysteine-dioxygenase-1-cdo1-gene-in-primary-gallbladder-cancer-and-gallbladder-disease
#6
Kazuharu Igarashi, Keishi Yamashita, Hiroshi Katoh, Keita Kojima, Yosuke Ooizumi, Nobuyuki Nishizawa, Ryo Nishiyama, Hiroshi Kawamata, Hiroshi Tajima, Takashi Kaizu, Yusuke Kumamoto, Masahiko Watanabe
BACKGROUND: Aberrant promoter DNA methylation of the cysteine dioxygenase 1 (CDO1) gene is found in various human cancers and is associated with clinical outcome. In this study, we assessed for the first time the clinicopathological significance of CDO1 methylation in primary gallbladder cancer (GBC) in comparison with non-malignant gallbladder disease. METHODS: CDO1 DNA methylation was quantified using quantitative TaqMan methylation specific PCR (Q-MSP) in 99 primary GBC patients together with the 78 corresponding non-tumor tissues and 26 benign gallbladder disease (including 7 patients with xanthogranulomatous cholecystitis) who underwent surgical resection between 1986 and 2014...
2017: PloS One
https://www.readbyqxmd.com/read/29161240/rapid-nodal-staging-of-head-and-neck-cancer-surgical-specimens-with-flow-cytometric-analysis
#7
Valtteri Häyry, Åsa Kågedal, Eric Hjalmarsson, Pedro Farrajota Neves da Silva, Cecilia Drakskog, Gregori Margolin, Susanna Kumlien Georén, Eva Munck-Wikland, Ola Winqvist, Lars Olaf Cardell
BACKGROUND: Detection of metastatic spread of head and neck cancer to cervical lymph nodes is essential for optimal design of therapy. Undetected metastases lead to mortality, which can be prevented by better detection methods. METHODS: We analysed 41 lymph nodes from 19 patients with oral squamous cell carcinoma (OSCC). Each lymph node was divided in two, one half processed for histopathology and the other half dissociated into single-cell suspension, stained for the carcinoma cell markers cytokeratin 5/8 (CK5/8), epithelial cell adhesion molecule (EpCAM) and epithelial mucin (MUC-1), and analysed with flow cytometry...
November 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29161205/imbalance-between-clinical-and-pathologic-staging-in-the-updated-american-joint-commission-cancer-staging-system-for-human-papillomavirus-positive-oropharyngeal-cancer
#8
Carole Fakhry, Jose P Zevallos, David W Eisele
No abstract text is available yet for this article.
November 21, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29160897/social-integration-and-survival-after-diagnosis-of-colorectal-cancer
#9
Elizabeth A Sarma, Ichiro Kawachi, Elizabeth M Poole, Shelley S Tworoger, Edward L Giovannucci, Charles S Fuchs, Ying Bao
BACKGROUND: Although larger social networks have been associated with lower all-cause mortality, few studies have examined whether social integration predicts survival outcomes among patients with colorectal cancer (CRC). The authors examined the association between social ties and survival after CRC diagnosis in a prospective cohort study. METHODS: Participants included 896 women in the Nurses' Health Study who were diagnosed with stage I, II, or III CRC between 1992 and 2012...
November 21, 2017: Cancer
https://www.readbyqxmd.com/read/29160382/lung-cancer-changes-in-histology-gender-and-age-over-the-last-30-years-in-brazil
#10
Maria Teresa Ruiz Tsukazan, Álvaro Vigo, Vinícius Duval da Silva, Carlos Henrique Barrios, Jayme de Oliveira Rios, José Antônio de Figueiredo Pinto
OBJECTIVE: To describe the trends in tumor histology, gender and age among patients with non-small cell lung cancer (NSCLC) treated with lung resection. The histology of lung cancer has changed in developed countries, and there is still little information available on the topic for developing countries. METHODS: This was a retrospective study of 1,030 patients with NSCLC treated with lung resection between 1986 and 2015 at a university hospital in southern Brazil...
September 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29160171/recent-pregnancy-is-not-associated-with-high-risk-pathological-features-of-well-differentiated-thyroid-cancer
#11
Angela J Chen, Masha J Livhits, Lin Du, James X Wu, Eric James Kuo, Michael W Yeh, Angela M Leung
BACKGROUND: Thyroid cancer is commonly diagnosed in the first postpartum year, supporting the theory that high levels of estrogen may stimulate progression of hormone-mediated thyroid cancer. The aim of this study was to assess the effect of recent pregnancy on histopathologic disease characteristics of well-differentiated thyroid cancer (WDTC). METHODS: Cases of WDTC (1999-2012) were identified from the California Cancer Registry and linked to data from the Office of Statewide Health Planning and Development...
November 21, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29160154/staging-neck-dissection-and-transoral-robotic-surgery-treatment-algorithm-in-palatine-tonsil-cancer
#12
Joseph Spellman, Ryan Sload, Paul Kim, Peter Martin, Gabriel Calzada
Objective This study introduces a treatment algorithm based on staging neck dissection to identify patients with palatine tonsil squamous cell carcinoma who can be effectively treated with single-modality transoral robotic surgery while maintaining quality of life. Study Design Retrospective case series. Setting Kaiser Permanente Southern California Medical Group from 2012 to 2017. Subjects and Methods Patients with early-stage (T1/2) palatine tonsil squamous cell carcinoma with clinically and radiographically N0 necks underwent staging neck dissection...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29159951/prevalence-of-sun-protection-behaviors-in-hispanic-youth-residing-in-a-high-ultraviolet-light-environment
#13
Lisa Altieri, Kimberly A Miller, Jimi Huh, David H Peng, Jennifer B Unger, Jean L Richardson, Martin W Allen, Myles Cockburn
Although rates of late-stage melanoma are rising in Hispanics, particularly those living in high ultraviolet light environments, little is known about the prevalence of sun protective behaviors in Hispanic children. We analyzed baseline data including frequency of sunburn, sun protective behaviors, level of U.S. acculturation, and skin phototype from a cross-sectional survey of 2003 Hispanic elementary school children in Los Angeles, California, who participated in a skin cancer prevention intervention. Although the Hispanic children reported frequently engaging in some sun protective behaviors, they also had a high rate of sunburn (59%) that exceeded previous national estimates for non-Hispanic white children (43%)...
November 21, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29159910/patients-with-advanced-hepatocellular-carcinoma-need-a-personalized-management-a-lesson-from-clinical-practice
#14
Edoardo G Giannini, Laura Bucci, Francesca Garuti, Matteo Brunacci, Barbara Lenzi, Matteo Valente, Eugenio Caturelli, Giuseppe Cabibbo, Fabio Piscaglia, Roberto Virdone, Martina Felder, Francesca Ciccarese, Francesco Giuseppe Foschi, Rodolfo Sacco, Gianluca Svegliati Baroni, Fabio Farinati, Gian Lodovico Rapaccini, Andrea Olivani, Antonio Gasbarrini, Maria Di Marco, Filomena Morisco, Marco Zoli, Alberto Masotto, Franco Borzio, Luisa Benvegnù, Fabio Marra, Antonio Colecchia, Gerardo Nardone, Mauro Bernardi, Franco Trevisani
The Barcelona Clinic Liver Cancer advanced stage (BCLC C) of hepatocellular carcinoma (HCC) includes a heterogeneous population, where sorafenib alone is the recommended treatment. In this study our aim was to assess treatment and overall survival (OS) of BCLC C patients sub-classified according to clinical features (Performance Status [PS], macro-vascular invasion [MVI], extra-hepatic spread [EHS] or MVI+EHS) determining their allocation to this stage. From the Italian Liver Cancer database, we analysed 835 consecutive BCLC C patients diagnosed between 2008 and 2014...
November 21, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29159866/administration-of-adjuvant-chemotherapy-for-stage-ii-iii-colon-cancer-patients-a-european-population-based-study
#15
Masoud Babaei, Yesilda Balavarca, Lina Jansen, Valery Lemmens, Felice N van Erning, Liesbet van Eycken, Evelien Vaes, Annika Sjövall, Bengt Glimelius, Cornelia M Ulrich, Petra Schrotz-King, Hermann Brenner
The advantage of adjuvant chemotherapy (ACT) for treating stage III colon cancer patients is well established and widely accepted. However, many patients with stage III colon cancer do not receive ACT. Moreover, there are controversies around the effectiveness of ACT for stage II patients. We investigated the administration of ACT and its association with overall survival in resected stage II (overall and stratified by low-/high-risk) and stage III colon cancer patients in three European countries including The Netherlands (2009-2014), Belgium (2009-2013), and Sweden (2009-2014)...
November 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29159834/linc00473-antagonizes-the-tumour-suppressor-mir-195-to-mediate-the-pathogenesis-of-wilms-tumour-via-ikk%C3%AE
#16
Shibo Zhu, Wen Fu, Liyu Zhang, Kai Fu, Jinhua Hu, Wei Jia, Guochang Liu
OBJECTIVES: Although dramatic improvements of overall survival has achieved in patients with favourable histology Wilms tumour, disease recurrence is still the main cause of cancer-related death in childhood. Long non-coding RNAs (lncRNAs) as oncogenes or tumour suppressors are dysregulated during carcinogenesis. However, the role of lncRNAs in the pathogenesis of Wilms tumour is unknown. Here, an lncRNA LINC00473 signature that functioned as oncogene was identified in Wilms tumour. METHODS: Wilms tumour (n = 15) and relative normal tissues were collected...
November 20, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29159773/japan-society-of-gynecologic-oncology-guidelines-2015-for-the-treatment-of-vulvar-cancer-and-vaginal-cancer
#17
Toshiaki Saito, Tsutomu Tabata, Hitoshi Ikushima, Hiroyuki Yanai, Hironori Tashiro, Hitoshi Niikura, Takeo Minaguchi, Toshinari Muramatsu, Tsukasa Baba, Wataru Yamagami, Kazuya Ariyoshi, Kimio Ushijima, Mikio Mikami, Satoru Nagase, Masanori Kaneuchi, Nobuo Yaegashi, Yasuhiro Udagawa, Hidetaka Katabuchi
BACKGROUND: Vulvar cancer and vaginal cancer are relatively rare tumors, and there had been no established treatment principles or guidelines to treat these rare tumors in Japan. The first version of the Japan Society of Gynecologic Oncology (JSGO) guidelines for the treatment of vulvar cancer and vaginal cancer was published in 2015 in Japanese. OBJECTIVE: The JSGO committee decided to publish the English version of the JSGO guidelines worldwide, and hope it will be a useful guide to physicians in a similar situation as in Japan...
November 20, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29159744/treatment-and-outcome-of-synchronous-colorectal-carcinomas-a-nationwide-study
#18
A C R K Bos, R A Matthijsen, F N van Erning, M G H van Oijen, H J T Rutten, V E P P Lemmens
BACKGROUND: Synchronous colorectal carcinomas (CRC) occur in 1-8% of patients diagnosed with CRC. This study evaluated treatment patterns and patient outcomes in synchronous CRCs compared with solitary CRC patients. METHODS: All patients diagnosed with primary CRC between 2008 and 2013, who underwent elective surgery, were selected from the Netherlands Cancer Registry. Using multivariable regressions, the effects of synchronous CRC were assessed for both short-term outcomes (prolonged postoperative hospital admission, anastomotic leakage, postoperative 30-day mortality, administration of neoadjuvant or adjuvant treatment), and 5-year relative survival (RS)...
November 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29159572/comparison-of-positron-emission-tomography-computed-tomography-and-magnetic-resonance-imaging-for-posttherapy-evaluation-in-patients-with-advanced-cervical-cancer-receiving-definitive-concurrent-chemoradiotherapy
#19
Tzu-Pei Su, Gigin Lin, Yu-Ting Huang, Feng-Yuan Liu, Chun-Chieh Wang, Angel Chao, Hung-Hsueh Chou, Tzu-Chen Yen, Chyong-Huey Lai
PURPOSE: Our purpose was to assess the diagnostic performance of positron emission tomography/computed tomography (PET/CT) and pelvic/abdominal magnetic resonance imaging (MRI) after concurrent chemoradiotherapy (CCRT) for posttherapy evaluation in patients with advanced cervical cancer. METHODS: Patients with cervical squamous cell carcinoma, either with advanced FIGO stage or with positive pelvic or para-aortic lymph node (PALN), received PET/CT using [(18)F]fluorodeoxyglucose and MRI including diffusion-weighted imaging between 2 and 3 months after CCRT completion...
November 20, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29159318/young-donor-white-blood-cell-immunotherapy-induces-extensive-tumor-necrosis-in-advanced-stage-solid-tumors
#20
Dipnarine Maharaj, Pedro G Vianna, Wendy Ward, Anthony J Messina, Trevor Rayborn, Jacqueline V Gouvea, Richard D Hammer, Zheng Cui
Background: In the past decade, a variety of immunotherapy approaches focused predominantly on the adaptive immune system have shown unprecedented responses in patients with advanced-stage malignancies. However, studies in spontaneous regression/complete resistance (SR/CR) mice and humans have shown a novel innate cancer-killing activity mediated by granulocytes, which is completely transferable for prevention or therapy against established malignancies. Methods: Three patients with advanced, relapsed or refractory solid tumors for which no standard therapy was available or was refused were enrolled into this ongoing combined phase I/II open label clinical trial testing the safety, dose tolerance, and possible antineoplastic efficacy of sequential infusions of HLA-mismatched non-irradiated allogeneic white cells (68-91% granulocytes) collected by leukapheresis from young, healthy donors (age 18-35) following mobilization with granulocyte colony stimulating factor (G-CSF) and dexamethasone...
October 2017: Heliyon
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