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Low intensity ultrasound

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https://www.readbyqxmd.com/read/28931989/effect-of-low-intensity-pulsed-ultrasound-therapy-on-a-rat-knee-joint-contracture-model
#1
Masanori Watanabe, Satoshi Kojima, Masahiro Hoso
[Purpose] Histopathological investigation of the effects of low-intensity pulsed ultrasound (LIPUS) on joint components using a rat knee joint contracture model. [Subjects and Methods] Nineteen, 9-week-old Wistar male rats were divided into a control group (n=6) and an experimental group. Rats in the experimental group underwent cast immobilization of the right rear limb for 8 weeks. They were then randomly divided into a non-treatment group (n=6), which was raised under normal conditions for 4 weeks, and a treatment group (n=7), which underwent LIPUS for 4 weeks...
September 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28931908/drug-release-from-core-shell-pva-silk-fibroin-nanoparticles-fabricated-by-one-step-electrospraying
#2
Yang Cao, Fengqiu Liu, Yuli Chen, Tao Yu, Deshuai Lou, Yuan Guo, Pan Li, Zhigang Wang, Haitao Ran
Silk fibroin (SF), a FDA-approved natural protein, is renowned for its great biocompatibility, biodegradability, and mechanical properties. SF-based nanoparticles provide new options for drug delivery with their tunable drug loading and release properties. To take advantage of the features of carrier polymers, we present a one-step electrospraying method that combines SF, polyvinyl alcohol (PVA) and therapeutic drugs without an emulsion process. A distinct core-shell structure was obtained with the PVA core and silk shell after the system was properly set up...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28929363/all-in-one-low-intensity-pulsed-ultrasound-stimulation-system-using-piezoelectric-micromachined-ultrasonic-transducer-pmut-arrays-for-targeted-cell-stimulation
#3
Wonjun Lee, Seungjun Yoo, Joontaek Jung, Woojin Kang, Wei Wang, Cheil Moon, Hongsoo Choi
A novel cell-stimulation system was fabricated using 10 × 29 piezoelectric micromachined ultrasonic transducer (pMUT) arrays for targeted ultrasonic cell stimulation. Both the diameter of a single pMUT element and the edge-to-edge gap were 120 μm, and the size of a pMUT array was 2.27 × 6.84 mm, to be placed at the bottom of a Transwell. The measured resonance frequency of a single pMUT element was 1.48 ± 0.13 MHz and the measured acoustic intensity of the pMUT array was 0.15 ± 0.03 MPa at 1 mm away from the transducer...
September 19, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28929267/increasing-distribution-of-drugs-released-from-in-situ-forming-plga-implants-using-therapeutic-ultrasound
#4
Chawan Manaspon, Christopher Hernandez, Pinunta Nittayacharn, Selva Jeganathan, Norased Nasongkla, Agata A Exner
One of the challenges in developing sustained-release local drug delivery systems is the limited treatment volume that can be achieved. In this work, we examine the effectiveness of using low frequency, high intensity ultrasound to promote the spatial penetration of drug molecules away from the implant/injection site boundary upon release from injectable, phase inverting poly(lactic acid-co-glycolic acid) (PLGA) implants. Fluorescein-loaded PLGA solutions were injected into poly(acrylamide) phantoms, and the constructs were treated daily for 14 days with ultrasound at 2...
September 19, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28928844/inhibitory-effects-of-low-intensity-pulsed-ultrasound-sonication-on-the-proliferation-of-osteosarcoma-cells
#5
Toshihiro Matsuo, Keiji Sato, Takuya Matsui, Shigeyuki Sawada, Yoshitaka Muramatsu, Katsuhisa Kawanami, Masataka Deie
To date, there is limited data on the biological effects of low-intensity pulsed ultrasound (LIPUS) on primary malignant bone tumors. The purpose of the present study was to investigate the antitumor effects of LIPUS on osteosarcoma cells. The effects of LIPUS on cell viability, induction of apoptosis, mitochondrial membrane potential and intracellular signaling molecules in the LM8 osteosarcoma cell line were investigated. LIPUS inhibited cell viability (P=0.0022) and mitochondrial membrane potential (P=0...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28928042/effect-of-high-intensity-focused-ultrasound-hifu-in-conjunction-with-a-nanomedicines-microbubble-complex-for-enhanced-drug-delivery
#6
Hyounkoo Han, Hohyeon Lee, Kwangmeyung Kim, Hyuncheol Kim
Although nanomedicines have been intensively investigated for cancer therapy in the past, poor accumulation of nanomedicines in tumor sites remains a serious problem. Therefore, a novel drug delivery system is required to enhance accumulation and penetration of nanomedicines at the tumor site. Recently, high-intensity focused ultrasound (HIFU) has been highlighted as a non-invasive therapeutic modality, and showed enhanced therapeutic efficacy in combination with nanomedicines. Cavitation effect induced by the combination of HIFU and microbubbles results in transiently enhanced cell membrane permeability, facilitating improved drug delivery efficiency into tumor sites...
September 16, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28926276/polypyrrole-coated-perfluorocarbon-nanoemulsions-as-a-sono-photoacoustic-contrast-agent
#7
David Shicheng Li, Soon Joon Yoon, Ivan Pelivanov, M Frenz, Matthew O'Donnell, Lilo D Pozzo
A new contrast agent for combined photoacoustic and ultrasound imaging is presented. It has a liquid perfluorocarbon (PFC) core of about 250 nm diameter coated by a 30 nm thin polypyrrole (PPy) doped polymer shell emulsion which represents a broadband absorber covering the visible and near-infrared ranges (peak optical extinction at 1050 nm). When exposed to a sufficiently high intensity optical or acoustic pulse, the droplets vaporize to form microbubbles providing a strong increase in imaging sensitivity and specificity...
September 19, 2017: Nano Letters
https://www.readbyqxmd.com/read/28913353/the-effects-of-low-intensity-ultrasound-on-fat-reduction-of-rat-model
#8
Bill Zhou, Benny Yuk Kin Leung, Lei Sun
Nonfocused low-intensity ultrasound is generally believed to be less efficacious than High-Intensity Focused Ultrasound (HIFU) at body fat reduction; nevertheless, this technology has already been widely used clinically for body contouring purposes. This study aimed to evaluate the efficacy and safety of this new technology by applying 1 MHz nonfocused ultrasound at 3 W/cm(2) to the outer-thigh region of rat models. Ultrasonography measurement demonstrated an average reduction of 0.5 mm of subcutaneous fat thickness that persisted for at least three days after treatment...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28910426/optical-coherence-tomography-angiography-features-of-iris-racemose-hemangioma-in-4-cases
#9
Jason L Chien, Kareem Sioufi, Sandor Ferenczy, Emil Anthony T Say, Carol L Shields
Importance: Optical coherence tomography angiography (OCTA) allows visualization of iris racemose hemangioma course and its relation to the normal iris microvasculature. Objective: To describe OCTA features of iris racemose hemangioma. Design, Setting, and Participants: Descriptive, noncomparative case series at a tertiary referral center (Ocular Oncology Service of Wills Eye Hospital). Patients diagnosed with unilateral iris racemose hemangioma were included in the study...
September 14, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28906501/impact-of-cleaning-procedures-on-adhesion-of-living-cells-to-three-abutment-materials
#10
Christian Mehl, Matthias Kern, Anna Zimmermann, Sönke Harder, Steven Huth, Christine Selhuber-Unkel
PURPOSE: To test the adhesion properties of live gingival fibroblasts to three different implant abutment materials after five different cleaning procedures. MATERIALS AND METHODS: Highly polished discs of lithium disilicate (LS), zirconium dioxide (Zr), and titanium alloy (Ti) were fabricated. The specimens were cleaned by one of five different methods: steam (S), argon plasma (AP), ultrasound and disinfection (UD), ultrasound and sterilization in an autoclave (UA), or photofunctionalization with high-intensity ultraviolet light (PF)...
September 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28904322/a-preliminary-study-of-effects-of-low-intensity-pulsed-ultrasound-lipus-irradiation-on-dentoalveolar-ankylosis
#11
Tomoyasu Kiyokawa, Mitsuru Motoyoshi, Mizuki Inaba, Remi Sano, Akari Saiki, Go Torigoe, Masatake Asano, Noriyoshi Shimizu
The purpose of this experiment was to investigate whether low-intensity pulsed ultrasound (LIPUS) irradiation can inhibit dentoalveolar ankylosis in transplanted rat teeth. LIPUS irradiation (the pulsed ultrasound signal had a frequency of 3.0 MHz, a spatial average intensity of 30 mW/cm(2), and a pulse ratio of 1:4) was performed on the face over the re-planted teeth of rats for 4 weeks. After the rats were euthanized, we measured mobility (Periotest value [PTV]) of the transplanted and control teeth using a Periotest...
2017: Journal of Oral Science
https://www.readbyqxmd.com/read/28901969/disorders-of-consciousness-after-severe-brain-injury-therapeutic-options
#12
Caroline Schnakers, Martin M Monti
PURPOSE OF REVIEW: Very few options exist for patients who survive severe traumatic brain injury but fail to fully recover and develop a disorder of consciousness (e.g. vegetative state, minimally conscious state). RECENT FINDINGS: Among pharmacological approaches, Amantadine has shown the ability to accelerate functional recovery. Although with very low frequency, Zolpidem has shown the ability to improve the level of consciousness transiently and, possibly, also in a sustained fashion...
September 9, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28890088/management-of-local-relapse-after-prostate-cancer-radiotherapy-surgery-or-radiotherapy
#13
C Hennequin, J-M Hannoun-Lévi, F Rozet
Isolated local relapse after prostate cancer radiotherapy corresponds to 40% of biochemical failure. The management of these relapses is not well defined. Several strategies are available including surgery, high-intensity focused ultrasounds (HIFU), cryotherapy and reirradiation. Radical prostatectomy is the historical approach; biochemical control is obtained in 50 to 80% at 5 year. However, morbidity is higher after irradiation than as a first line treatment. Some limited series of HIFU and cryotherapy have been published with interesting results, but again the risk of urinary and rectal toxicity is high...
September 7, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28886723/pancreatic-injury-in-children-a-case-report-and-review-of-the-literature
#14
Fayza Haider, Mohammed Amin Al Awadhi, Eizat Abrar, Mooza Al Dossari, Hasan Isa, Husain Nasser, Hakima Al Hashimi, Sharif Al Arayedh
BACKGROUND: Trauma is the main cause of morbidity and mortality in the pediatric population. Blunt trauma to the abdomen accounts for the majority of abdominal injuries in children. Pancreatic injury, although uncommon (2 to 9%), is the fourth most common solid organ injury. Unlike other solid organ injuries, pancreatic trauma may be subtle and difficult to diagnose. Computed tomography currently is the imaging modality of choice. As the incidence of pancreatic injury in children sustaining blunt abdominal trauma is low, management remains a challenge...
September 9, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28884736/-the-application-of-low-frequency-ultrasound-for-the-comprehensive-treatment-and-rehabilitation-of-the-patients-presenting-with-chronic-endometritis
#15
Yu V Kovaleva
The incidence of chronic endometritis remains rather high despite considerable progress in reproductive medicine including the advent of the new methods for assisted reproduction; the pregnancy rate after the treatment of this condition is still unacceptably low. It implies the necessity of the careful preparation of endometrium for the implantation of the embryo especially in women with a history of unsuccessful outcomes of the IVF treatment. It calls for the development of the efficient therapeutic modalities for the management of chronic endometritis and restoration of the normal reproductive function; their introduction into the therapeutic algorithm remains equally relevant...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/28880412/diagnostic-efficiency-of-quantitative-contrast-enhanced-ultrasound-indicators-for-discriminating-benign-from-malignant-solid-thyroid-nodules
#16
Xiaohui Zhou, Ping Zhou, Zheyu Hu, Shuang Ming Tian, Yongfeng Zhao, Wengang Liu, Qiuzi Jin
OBJECTIVES: We aimed to determine the most efficient quantitative parameters to establish a contrast-enhanced ultrasound (US) assessment system for distinguishing between benign and malignant thyroid nodules. METHODS: A total of 167 patients with thyroid solitary nodules had the diagnosis confirmed by surgery or fine-needle aspiration. Quantitative contrast-enhanced US indicators (time to peak, time from peak to one-half, ascend slope, descend slope, peak intensity, and area under the curve [AUC]) were gathered in nodule and perinodule areas...
September 7, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28880170/rapid-spatial-mapping-of-focused-ultrasound-fields-using-a-planar-fabry-p%C3%A3-rot-sensor
#17
Eleanor Martin, Edward Z Zhang, James A Guggenheim, Paul C Beard, Bradley E Treeby
Measurement of high acoustic pressures is necessary in order to fully characterise clinical high-intensity focused ultrasound (HIFU) fields, and for accurate validation of computational models of ultrasound propagation. However, many existing measurement devices are unable to withstand the extreme pressures generated in these fields, and those that can often exhibit low sensitivity. Here, a planar Fabry-Pérot interferometer with hard dielectric mirrors and spacer was designed, fabricated, and characterised and its suitability for measurement of nonlinear focused ultrasound fields was investigated...
September 4, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28876129/relationship-between-occupational-physical-activity-and-subclinical-vascular-damage-in-moderate-altitude-dwellers
#18
Kristian Ujka, Rosa Maria Bruno, Luca Bastiani, Eva Bernardi, Paolo Sdringola, Nenad Dikic, Bikash Basyal, Sanjeeb Sundarshan Bhandari, Buddha Basnyat, Annalisa Cogo, Lorenza Pratali
Ujka, Kristian, Rosa Maria Bruno, Luca Bastiani, Eva Bernardi, Paolo Sdringola, Nenad Dikic, Bikash Basyal, Sanjeeb Sundarshan Bhandari, Buddha Basnyat, Annalisa Cogo, and Lorenza Pratali. Relationship between occupational physical activity and subclinical vascular damage in moderate-altitude dwellers. High Alt Med Biol. 18:249-257, 2017. BACKGROUND: Occupational physical activity (OPA) has been associated with increased cardiovascular (CV) events. The aim of this study was to investigate the association between OPA and markers of subclinical vascular damage among a moderate-altitude population living in the rural village of Chaurikharka (Nepal; 2600 m sea level)...
September 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28872552/pancreatoblastoma-with-metastatic-retroperitoneal-lymph-node-and-pet-ct
#19
Giuseppe Corrias, Monica Ragucci, Olca Basturk, Luca Saba, Lorenzo Mannelli
A previously healthy 4-year-old girl presented with petechial rash and low platelet count. There were no other symptoms. On abdominal ultrasound, a 4.7-cm heterogeneous mass was demonstrated anterior to the left kidney. An abdominal MRI subsequently performed demonstrated a heterogeneously enhancing mass at the same location extending to the pancreas and spleen. A surgical biopsy of the mass was obtained. Pathology reported a malignant epithelioid neoplasm consistent with pancreatoblastoma. The mass demonstrated intense FDG uptake on PET and an FDG avid retrocaval lymph node...
September 1, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28870737/chondrocyte-primary-cilium-is-mechanosensitive-and-responds-to-low-intensity-ultrasound-by-altering-its-length-and-orientation
#20
Anuradha Subramanian, Gaurav Budhiraja, Neety Sahu
The primary cilium has been implicated in mechanotransduction, however, its mechanosensory role in transducing signals under low-intensity ultrasound (LIUS) which has the potential to repair fractures and cartilage, remains uninvestigated. This study examined the impact of continuous-wave US, at the cell resonance frequency of 5.0MHz and pressure amplitude of either 14 or 60kPa, on the incidence, length and orientation of primary cilium in bovine articular chondrocytes. Visualization of primary cilium with acetylated α-tubulin staining demonstrated that the primary cilium was elongated, bent under US and these changes were reversible...
September 8, 2017: International Journal of Biochemistry & Cell Biology
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