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https://www.readbyqxmd.com/read/28445056/superior-plasticity-and-tabletability-of-theophylline-monohydrate
#1
Shao-Yu Chang, Changquan Calvin Sun
A theophylline monohydrate (THm) powder, with particle size and shape substantially similar to a theophylline anhydrate powder, was prepared by vapor mediated phase conversion. The elimination of possible contributions by particle size and shape to tableting properties made it possible to unambiguously identify the role of bonding area and bonding strength on powder tableting performance. It was also shown that accurate true density is essential for correct analysis and understanding of tableting behavior of THm...
April 26, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28439790/evaluating-fidelity-to-a-modified-niatx-process-improvement-strategy-for-improving-hiv-services-in-correctional-facilities
#2
Jennifer Pankow, Jennifer Willett, Yang Yang, Holly Swan, Richard Dembo, William M Burdon, Yvonne Patterson, Frank S Pearson, Steven Belenko, Linda K Frisman
In a study aimed at improving the quality of HIV services for inmates, an organizational process improvement strategy using change teams was tested in 14 correctional facilities in 8 US states and Puerto Rico. Data to examine fidelity to the process improvement strategy consisted of quantitative ratings of the structural and process components of the strategy and qualitative notes that explicate challenges in maintaining fidelity to the strategy. Fidelity challenges included (1) lack of communication and leadership within change teams, (2) instability in team membership, and (3) issues with data utilization in decision-making to implement improvements to services delivery...
April 24, 2017: Journal of Behavioral Health Services & Research
https://www.readbyqxmd.com/read/28438197/anti-malarial-landscape-in-myanmar-results-from-a-nationally-representative-survey-among-community-health-workers-and-the-private-sector-outlets-in-2015-2016
#3
Si Thu Thein, Hnin Su Su Khin, Aung Thi
BACKGROUND: In 2015/2016, an ACTwatch outlet survey was implemented to assess the anti-malarial and malaria testing landscape in Myanmar across four domains (Eastern, Central, Coastal, Western regions). Indicators provide an important benchmark to guide Myanmar's new National Strategic Plan to eliminate malaria by 2030. METHODS: This was a cross-sectional survey, which employed stratified cluster-random sampling across four regions in Myanmar. A census of community health workers (CHWs) and private outlets with potential to distribute malaria testing and/or treatment was conducted...
April 25, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28438146/correlates-associated-with-participation-in-physical-activity-among-adults-a-systematic-review-of-reviews-and-update
#4
Jaesung Choi, Miyoung Lee, Jong-Koo Lee, Daehee Kang, Ji-Yeob Choi
BACKGROUND: Understanding which factors influence participation in physical activity is important to improve the public health. The aim of the present review of reviews was to summarize and present updated evidence on personal and environmental factors associated with physical activity. METHODS: MEDLINE and EMBASE were searched for reviews published up to 31 Jan. 2017 reporting on potential factors of physical activity in adults aged over 18 years. The quality of each review was appraised with the Assessing the Methodological Quality of Systematic Reviews (AMSTAR) checklist...
April 24, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28437171/psychological-benefits-of-yoga-for-female-inmates
#5
Yoika Danielly, Colin Silverthorne
Female inmates involved in the Yoga Prison Project at two correctional facilities in South Carolina served as subjects. Inmates were selected from those who applied to participate in a ten-week trauma-focused yoga program. To create control and experimental groups, inmates who requested to participate were randomly assigned to be in the class (Treatment Group, n = 33) or a waitlist (Control Group, n = 17). Inmates on the waitlist subsequently joined the next class, so all who applied and were eligible participated in a yoga class...
April 24, 2017: International Journal of Yoga Therapy
https://www.readbyqxmd.com/read/28433885/electric-fields-within-clay-materials-how-to-affect-the-adsorption-of-metal-ions
#6
Xiong Li, Hang Li, Gang Yang
Electric fields exist ubiquitously in chemical and biological systems while how to affect the interfacial adsorption processes remain elusive. Here, molecular dynamics simulations are used to understand at a molecular level the adsorption of metal ions at the interface of aqueous solutions and clay materials that are generally endowed with strong electric fields. In absence of electric fields, even Cs(+), one of the strongest adsorbed metal ions, is facile to detach from solvated clay surfaces. Electric fields are critical to construct stable inner-sphere complexes and enhance pronouncedly the adsorption strengths of both inner- and outer-sphere complexes...
April 13, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28432993/chemical-biological-and-dna-markers-for-tracing-slaughterhouse-effluent
#7
P J Harvey, M P Taylor, H K Handley, S Foster, M R Gillings, A J Asher
Agricultural practices, if not managed correctly, can have a negative impact on receiving environments via waste disposal and discharge. In this study, a chicken slaughter facility on the rural outskirts of Sydney, Australia, has been identified as a possible source of persistent effluent discharge into a peri-urban catchment. Questions surrounding the facility's environmental management practices go back more than four decades. Despite there having never been a definitive determination of the facility's impact on local stream water quality, the New South Wales Environment Protection Authority (NSW EPA) has implemented numerous pollution reduction requirements to manage noise and water pollution at the slaughter facility...
April 19, 2017: Environmental Research
https://www.readbyqxmd.com/read/28429375/patient-characteristics-and-outcomes-related-to-successful-outpatient-competency-restoration
#8
Amy J Mikolajewski, Gina M Manguno-Mire, Kelly L Coffman, Sarah M Deland, John W Thompson
Criminal defendants have a fundamental right to a fair and speedy trial. However, individuals found incompetent to stand trial are unable to move forward in the adjudication process and are often mired in protracted legal proceedings. If competency restoration is statutorily permissible and can be conducted in the outpatient setting, we propose that it should be considered based on burgeoning empirical data. We present data from an outpatient forensic clinic in which individuals are conditionally released to receive competency restoration in the community...
April 20, 2017: Behavioral Sciences & the Law
https://www.readbyqxmd.com/read/28429325/gravitaxis-in-euglena
#9
Donat-P Häder, Ruth Hemmersbach
Motile microorganisms utilize a number of responses to external stimuli including light, temperature, chemicals as well as magnetic and electric fields. Gravity is a major clue to select a niche in their environment. Positive gravitaxis leads an organism down into the water column and negative gravitaxis brings it to the surface. In Euglena the precision of gravitaxis is regulated by an internal rhythm entrained by the daily light/dark cycle. This and the cooperation with phototaxis bring the cells into an optimal position in the water column...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28427371/inside-the-nation-s-largest-mental-health-institution-a-prevalence-study-in-a-state-prison-system
#10
Tala Al-Rousan, Linda Rubenstein, Bruce Sieleni, Harbans Deol, Robert B Wallace
BACKGROUND: The United States has the highest incarceration rate in the world which has created a public health crisis. Correctional facilities have become a front line for mental health care. Public health research in this setting could inform criminal justice reform. We determined prevalence rates for mental illnesses and related comorbidities among all inmates in a state prison system. METHODS: Cross-sectional study using the Iowa Corrections Offender Network which contains health records of all inmates in Iowa...
April 20, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28427337/treatment-seeking-behaviour-in-low-and-middle-income-countries-estimated-using-a-bayesian-model
#11
Victor A Alegana, Jim Wright, Carla Pezzulo, Andrew J Tatem, Peter M Atkinson
BACKGROUND: Seeking treatment in formal healthcare for uncomplicated infections is vital to combating disease in low- and middle-income countries (LMICs). Healthcare treatment-seeking behaviour varies within and between communities and is modified by socio-economic, demographic, and physical factors. As a result, it remains a challenge to quantify healthcare treatment-seeking behaviour using a metric that is comparable across communities. Here, we present an application for transforming individual categorical responses (actions related to fever) to a continuous probabilistic estimate of fever treatment for one country in Sub-Saharan Africa (SSA)...
April 20, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28422499/development-of-a-18f-labeled-radiotracer-with-improved-brain-kinetics-for-positron-emission-tomography-imaging-of-translocator-protein-18-kda-in-ischemic-brain-and-glioma
#12
Masayuki Fujinaga, Rui Luo, Katsushi Kumata, Yiding Zhang, Akiko Hatori, Tomoteru Yamasaki, Lin Xie, Wakana Mori, Yusuke Kurihara, Masanao Ogawa, Nobuki Nengaki, Feng Wang, Ming-Rong Zhang
We designed four novel acetamidobenzoxazolone compounds 7a-d as candidates of positron emission tomography (PET) radiotracers for imaging translocator protein (18 kDa, TSPO) in ischemic brain and glioma. Among these compounds, 2-(5-(6-fluoropyridin-3-yl)-2-oxobenzo[d]oxazol-3(2H)-yl)-N-methyl-N-phenylacetamide (7d) exhibited high binding affinity (Ki = 13.4 nM) with TSPO and moderate lipophilicity (LogD: 1.92). [18F]7d was radiosynthesized by [18F]fluorination of the bromopyridine precursor 7h with [18F]F- at 12 ± 3% radiochemical yield (n = 6, decay-corrected)...
April 19, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28421890/inmate-health-care-provided-in-an-emergency-department
#13
Lindsey Koester, Jay M Brenner, Aimee Goulette, Susan M Wojcik, William Grant
The United States has the highest rate of incarceration in the world. Many correctional facilities have outsourced the medical care for this population that often presents with complex health issues. This study evaluates the reasons that inmates present to an emergency department (ED) and compares them to the general population ED visits. The most common presenting complaints were trauma (16.8%), abdominal pain (13.5%), chest pain (9.0%), and self-injury (8.7%). These presenting complaints differed significantly from those of the general population (abdominal pain [8...
April 2017: Journal of Correctional Health Care
https://www.readbyqxmd.com/read/28421654/short-term-outcomes-of-small-incision-cataract-surgery-provided-by-a-regional-population-in-the-pacific
#14
Riyaz Bhikoo, Hans Vellara, Salome Lolokabaira, Neil Murray, Biu Sikivou, Charles McGhee
BACKGROUND: To describe patient demographics, visual and surgical outcomes of a cohort undergoing Small Incision Cataract Surgery (SICS) at a Pacific regional ophthalmic training facility. DESIGN: Prospective, longitudinal study conducted at the Pacific Eye Institute, Fiji. PARTICIPANTS: 156 patients underwent SICS. METHODS: Preoperatively, a complete ophthalmic examination, including pachymetry and macular Optical Coherence Tomography (OCT) performed by two independent investigators...
April 19, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28416016/variation-in-rates-of-icu-readmissions-and-post-icu-in-hospital-mortality-and-their-association-with-icu-discharge-practices
#15
Nelleke van Sluisveld, Ferishta Bakhshi-Raiez, Nicolette de Keizer, Rebecca Holman, Gert Wester, Hub Wollersheim, Johannes G van der Hoeven, Marieke Zegers
BACKGROUND: Variation in intensive care unit (ICU) readmissions and in-hospital mortality after ICU discharge may indicate potential for improvement and could be explained by ICU discharge practices. Our objective was threefold: (1) describe variation in rates of ICU readmissions within 48 h and post-ICU in-hospital mortality, (2) describe ICU discharge practices in Dutch hospitals, and (3) study the association between rates of ICU readmissions within 48 h and post-ICU in-hospital mortality and ICU discharge practices...
April 17, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28414415/ultrasonography-for-confirmation-of-gastric-tube-placement
#16
REVIEW
Hiraku Tsujimoto, Yasushi Tsujimoto, Yukihiko Nakata, Mai Akazawa, Yuki Kataoka
BACKGROUND: Gastric tubes are commonly used for the administration of drugs and tube feeding for people who are unable to swallow. Feeding via a tube misplaced in the trachea can result in severe pneumonia. Therefore, the confirmation of tube placement in the stomach after tube insertion is important. Recent studies have reported that ultrasonography provides good diagnostic accuracy estimates in the confirmation of appropriate tube placement. Hence, ultrasound could provide a promising alternative to X-rays in the confirmation of tube placement, especially in settings where X-ray facilities are unavailable or difficult to access...
April 17, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28410398/do-people-who-experience-incarceration-age-more-quickly-exploratory-analyses-using-retrospective-cohort-data-on-mortality-from-ontario-canada
#17
Fiona G Kouyoumdjian, Evgeny M Andreev, Rohan Borschmann, Stuart A Kinner, Andres McConnon
OBJECTIVES: We aimed to explore whether mortality data are consistent with the view that aging is accelerated for people with a history of incarceration compared to the general population, using data on mortality rates and life expectancy for persons in Ontario, Canada. METHODS: We obtained data from the Ontario Ministry of Community Safety and Correctional Services on all adults admitted to provincial correctional facilities in Ontario in 2000, and linked these data with death records from provincial vital statistics between January 1, 2000 and December 31, 2012...
2017: PloS One
https://www.readbyqxmd.com/read/28406525/an-improved-radiosynthesis-of-o-2-18-f-fluoroethyl-o-p-nitrophenyl-methylphosphonate-a-first-in-class-cholinesterase-pet-tracer
#18
Kiel D Neumann, Charles M Thompson, Joseph E Blecha, John M Gerdes, Henry F VanBrocklin
O-(2-Fluoroethyl)-O-(p-nitrophenyl) methylphosphonate 1 is an organophosphate (OP) cholinesterase inhibitor, which creates a phosphonyl-serine covalent adduct at the enzyme active site blocking cholinesterase activity in vivo. The corresponding radiolabeled O-(2-[(18) F]fluoroethyl)-O-(p-nitrophenyl) methylphosphonate, [(18) F]1, has been previously prepared and found to be an excellent positron emission tomography (PET) imaging tracer for assessment of cholinesterases in live brain, peripheral tissues and blood...
April 12, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28403350/improving-reproducibility-and-external-validity-the-role-of-standardization-and-data-reporting-of-laboratory-rat-husbandry-and-housing
#19
José Luiz Fontoura-Andrade, Rivadávio Fernandes Batista de Amorim, João Batista de Sousa
Purpose: To identify the most relevant flaws in standardization in husbandry practices and lack of transparency to report them. This review proposes some measures in order to improve transparency, reproducibility and eventually external validity in experimental surgery experiments with rat model. Methods: We performed a search of scientific articles in PUBMED data base. The survey was conducted from august 2016 to January 2017. The keywords used were "reproducibility", "external validity", "rat model", "rat husbandry", "rat housing", and the time frame was up to January 2017...
March 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28402169/delta-check-practices-and-outcomes-a-q-probes-study-involving-49-health-care-facilities-and-6541-delta-check-alerts
#20
Ron B Schifman, Michael Talbert, Rhona J Souers
CONTEXT: - Delta checks serve as a patient-based quality control tool to detect testing problems. OBJECTIVE: - To evaluate delta check practices and outcomes. DESIGN: - Q-Probes participants provided information about delta check policies and procedures. Information about investigations, problems, and corrective actions was prospectively collected for up to 100 testing episodes involving delta check alerts. RESULTS: - Among 4505 testing episodes involving 6541 delta check alerts, the median frequencies of actions taken among 49 laboratories were clinical review, 38...
April 12, 2017: Archives of Pathology & Laboratory Medicine
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