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https://www.readbyqxmd.com/read/28339677/development-of-a-food-allergy-knowledge-test-for-parents
#1
Amy L Hahn, Lynnda M Dahlquist, Jessica L Hoehn, Mary Elizabeth Bollinger
Objective : To create a measure of food allergy (FA) knowledge for parents of children with FA. The food allergy knowledge test (FAKT) was developed following rigorous test-construction guidelines. The preliminary 110-item pool content was developed in consultation with FA experts. After cognitive interviews and revisions, an 88-item preliminary version was administered to 370 parents of children with FA who were recruited online and from an allergy clinic. After item difficulty, discrimination, item-scale correlations analyses, and assessment of internal consistency, a revised 57-item version was administered to a new clinic-based sample (77 parents)...
February 19, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/28337267/exploration-of-the-effect-of-probiotics-supplementation-on-intestinal-microbiota-of-food-allergic-mice
#2
Bo Yang, Liang Xiao, Sheng Liu, Xiaoyu Liu, Yan Luo, Qiongmei Ji, Pingchang Yang, Zhigang Liu
Environmental factor-induced alterations in intestinal microbiota have been demonstrated to be associated with increasing prevalence of food allergy. However, it is not clear to what extent oral administration of probiotics can affect gut microbiota composition, thus inhibiting food allergy development. Using ovalbumin (OVA)-sensitized murine model, it was demonstrated that probiotics ameliorated allergic symptoms, including reducing OVA specific-IgE, and -IgG1 levels in the serum, Th2 cytokines release in spleen, and occurrence of diarrhea...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28337229/allergic-enteritis-in-children
#3
REVIEW
Mieczysława Czerwionka-Szaflarska, Ewa Łoś-Rycharska, Julia Gawryjołek
The gastrointestinal form of food allergy is very common in children. The most frequently observed types are allergic proctitis and proctocolitis. In most cases the symptoms subside within the first 2 months of life. The babies seem healthy, and the only abnormality is a small amount of blood in stool. Symptoms can also include small intestine inflammation and colitis. Patients may present with irritability, abdominal pain, flatulence, colic, postprandial vomiting, chronic diarrhoea, and hindered physical development...
2017: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/28328103/characterization-of-maize-chitinase-a-a-tough-allergenic-molecule
#4
Mariateresa Volpicella, Claudia Leoni, Immacolata Fanizza, Marco Distaso, Guido Leoni, Laura Farioli, Todd Naumann, Elide Pastorello, Luigi Ruggiero Ceci
BACKGROUND: Food allergies are recognized as an increasing health concern. They are caused by specific proteins called food allergens. Proteins commonly identified as food allergens tend to have one of about 30 different biochemical activities. This leads to the assumption that food allergens must have specific structural features which causes their allergenicity. But these structural features are not completely understood. Uncovering the structural basis of allergenicity would allow improved diagnosis and therapy of allergies and would provide insights for safer food production...
March 22, 2017: Allergy
https://www.readbyqxmd.com/read/28326616/high-prevalence-of-sensitization-to-gibberellin-regulated-protein-peamaclein-in-fruit-allergies-with-negative-immunoglobulin-e-reactivity-to-bet-v-1-homologs-and-profilin-clinical-pattern-causative-fruits-and-cofactor-effect-of-gibberellin-regulated-protein
#5
Naoko Inomata, Mami Miyakawa, Michiko Aihara
Gibberellin-regulated protein (GRP) is a new allergen in peach allergy, with an amino acid sequence very well conserved through several botanical species. We investigated the allergenicity of GRP in fruit allergies other than peaches and identified the clinical characteristics of fruit allergy patients with GRP sensitization. One hundred consecutive Japanese patients with fruit allergies were enrolled in the present study. To identify the features of GRP sensitization, we selected patients with negative ImmunoCAP results for Bet v 1 homologs and profilin, which are marker allergens for pollen-food allergy syndrome (PFAS), or lipid transfer protein...
March 22, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28323676/impact-of-elimination-diets-on-nutrition-and-growth-in-children-with-multiple-food-allergies
#6
Carina Venter, Alessandra Mazzocchi, Kate Maslin, Carlo Agostoni
PURPOSE OF REVIEW: Growth and nutritional intake of children with cows' milk allergy and other food allergens has been thoroughly investigated in recent years across many different countries and age groups. An impaired growth in atopic children should not be attributed only to a high number of allergens and foods to be avoided, but to a general condition of 'sub-inflammation', which unfavorably affects the absorption and utilization of fuel and substrates. Atopic study participants may represent a good target for personalized nutrition and in this review we sought to outline many of the issues that should be taken into account when dietitians advise patients regarding food avoidance and expected effects on growth...
March 18, 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28321292/low-percentage-of-clinically-relevant-pistachio-nut-and-mango-co-sensitisation-in-cashew-nut-sensitised-children
#7
J P M van der Valk, R El Bouche, R Gerth van Wijk, H de Groot, H J Wichers, A E J Dubois, N W de Jong
BACKGROUND: Cashew nut, pistachio nut and mango belong to the Anacardiaceae family and are botanically related. Therefore, cashew nut sensitised children are frequently advised to eliminate cashew nuts and pistachio nuts from their diet. The 'Improvement of Diagnostic mEthods for ALlergy assessment (IDEAL trial number NTR3572) study showed that cashew nut sensitised children were co-sensitised to pistachio nut in 98% of cases and to mango in 21% of cases. The aim of this follow-up study to IDEAL is to assess the clinical relevance of co-sensitisation to pistachio nut and mango in cashew nut sensitised children...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28320170/evaluating-the-association-of-allergies-with-multiple-sclerosis-susceptibility-risk-and-disease-activity-in-a-pediatric-population
#8
Theresa Bourne, Michael Waltz, T C Casper, K Kavak, G Aaen, A Belman, L Benson, M Candee, T Chitnis, J Graves, B Greenberg, M Gorman, Y Harris, L Krupp, T Lotze, S Mar, J Ness, C Olsen, S Roalstad, M Rodriguez, J Rose, J Rubin, T Schreiner, J M Tillema, I Kahn, A Waldman, L Barcellos, E Waubant, B Weinstock-Guttman
BACKGROUND: Multiple sclerosis (MS) and allergies are both considered to be related to imbalanced Th1 and Th2 immune responses. Previous studies evaluating the relationship between MS and allergies provide conflicting results. OBJECTIVE: To assess allergies and asthma as risk factors for MS and as predictors of MS relapses in a pediatric cohort. METHODS: The environment and genetic risk factors for pediatric MS study is a national case-control project with 16 participating US sites...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319482/immunotherapy-for-food-allergy
#9
William R Reisacher, Wesley Davison
PURPOSE OF REVIEW: The current review discusses strategies for administering specific immunotherapy (SIT) for the treatment of food allergy. It focuses on three delivery routes for food allergens, immunomodulatory adjuvants and allergen modifications. RECENT FINDINGS: Interest in SIT for food allergy has been increasing significantly. Sublingual immunotherapy is effective for desensitization with a very favorable adverse event profile. Epicutaneous immunotherapy is also effective, most notably in younger children, with a high rate of local reactions...
March 17, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/28318190/successful-administration-of-measles-rubella-mumps-vaccine-by-graded-challenge-in-a-case-with-anaphylaxis-after-prior-vaccination
#10
Tuba Tuncel, Ozlem Sancakli, Ece Ozdogru
Egg allergy is one of the most common food allergies during childhood along with cow's milk allergy. The measles-mumpsrubella (MMR) vaccine is included in the pediatric immunization schedule and contains egg protein. The currently accepted opinion is that the MMR vaccination should be done in a single dose under medical observation in patients with egg allergy. Although it is reported that the MMR vaccine is safe for that patients, there are some patients who developed anaphylaxis. Generally, the development of anaphylaxis after the previous vaccination is reported as a contraindication...
April 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28318108/neonatal-mono-colonization-of-germ-free-mice-with-lactobacillus-casei-enhances-casein-immunogenicity-after-oral-sensitization-to-cow-s-milk
#11
Matieny Aicha Maiga, Stéphanie Morin, Hervé Bernard, Sylvie Rabot, Karine Adel -Patient, Stéphane Hazebrouck
SCOPE: Food allergy is an increasing global health problem and perinatal administration of probiotic bacteria is currently under investigation in order to prevent the development of allergic diseases. Here, we investigated the impact of neonatal mono-colonization of mice with Lactobacillus casei BL23 on an oral sensitization to cow's milk. METHODS AND RESULTS: Mono-colonized (LC) mice were obtained by inoculating L. casei to germ-free (GF) parents. Nine-week-old GF, LC and conventional (CV) mice were orally sensitized to cow's milk with cholera toxin as adjuvant...
March 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28317623/food-allergy-what-we-know-now
#12
REVIEW
Lindsey E Moore, Patricia H Stewart, Richard D deShazo
Food allergy is an adverse immune reaction that occurs reproducibly on exposure to a given food. Prevalence rates of food allergy continue to increase worldwide, sparking continual research efforts in finding a suitable and safe cure. Food avoidance, the current standard of care, can be difficult to achieve. This review aims to provide a broad overview of immunoglobulin E-mediated food allergy, highlighting its epidemiology, masqueraders, immunopathophysiology, clinical presentation, diagnostic work-up and available preventative and treatment strategies...
April 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28315886/update-on-timing-and-source-of-allergenic-foods
#13
Debra J Palmer
As the prevalence of food allergies in many communities continues to rise, the question of when in infancy to introduce any solid foods, or specific 'more allergenic' foods, as a food allergy prevention strategy has been debated. Observational studies have found that introducing any solid foods prior to 4 months of age was associated with an increased risk of allergic disease. Hence, the current allergy prevention consensus recommendation is that the introduction of any solid foods should commence after 4 months of age...
2017: Nestlé Nutrition Institute Workshop Series
https://www.readbyqxmd.com/read/28315226/recent-advances-in-the-detection-of-allergens-in-foods
#14
Silvia de la Cruz, Inés López-Calleja, Rosario Martín, Isabel González, Marcos Alcocer, Teresa García
Food allergy is a public health issue that has significantly increased worldwide in the past decade affecting consumers' quality of life and making increasing demands on health service resources. Despite recent advances in many areas of diagnosis and treatment, our general knowledge of the basic mechanisms of the disease remained limited, i.e., not at pace with the exponential number of new cases and the explosion of the new technologies. For sensitized individuals, the only effective way to prevent allergic reactions is the strict avoidance of the offending food...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28315221/t-cell-proliferation-assay-determination-of-immunodominant-t-cell-epitopes-of-food-allergens
#15
Madhan Masilamani, Mariona Pascal, Hugh A Sampson
Characterization of allergen-specific T cells is critical to understand their contribution to disease pathogenesis. The identification of immunodominant T-cell epitopes is crucial for development of T-cell-based vaccines. Peptide-specific T-cell proliferation studies are usually performed in a library of short synthetic peptides (15mer or 20mer) with 3 or 5 offset spanning the entire length of the allergen. T-cell peptide epitopes lack the primary and tertiary structure of the native protein to cross-link IgE, but retain the ability to stimulate T cells...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28315220/ige-epitope-mapping-using-peptide-microarray-immunoassay
#16
Jing Lin, Hugh A Sampson
IgE epitope mapping has the potential to become an additional tool for food allergy diagnosis/prognosis and to lead to a better understanding of the pathogenesis and tolerance induction of food allergy. Due to its ability to screen thousands of targets in parallel using small volumes of sample, peptide microarray has greatly facilitated large-scale IgE epitope mapping. In the past 10 years, we have developed and optimized a reliable and sensitive peptide microarray immunoassay, which has been successfully applied for IgE epitope mapping of many food allergens in our lab...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28315219/assessment-of-ige-reactivity-of-%C3%AE-casein-by-western-blotting-after-digestion-with-simulated-gastric-fluid
#17
Sara Benedé, Rosina López-Fandiño, Elena Molina
Cow's milk allergy is defined as an immunologically mediated adverse reaction to cow's milk proteins and it is usually, along with hen's egg allergy, the first food allergy identified in childhood.One of the main aspects to consider when evaluating the allergenic potential of food proteins is the effect of gastric digestion. It is known that allergens are usually able to survive the harsh acidic environment of the stomach, tolerate the presence of surfactants, and resist digestion by pepsin. They might also be digested into high molecular weight peptide fragments, which retain the same, or sometimes increased, IgE-binding...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28315218/use-of-humanized-rs-atl8-reporter-system-for-detection-of-allergen-specific-ige-sensitization-in-human-food-allergy
#18
Eman Ali Ali, Ryosuke Nakamura, Franco H Falcone
Allergen-specific Immunoglobulin E (IgE) determination lies at the heart of diagnosis of sensitization to food and other allergens. In the past few years, reporter systems capable of detecting the presence of allergen-specific IgE have been developed by several labs. These rely on humanized rat basophil leukemia cell lines stably transfected with reporter genes such as firefly luciferase. In this chapter, we describe protocols for the use of the RS-ATL8 cell line (IgE cross-linking-induced luciferase expression; EXiLE) in 96-well and 384-well formats...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28315217/basophil-degranulation-assay
#19
Madhan Masilamani, Mohanapriya Kamalakannan, Hugh A Sampson
Basophil degranulation assay has gained importance over the last decade in both diagnosis of food allergy and evaluation of progression of immunotherapy. This assay involves the identification and quantification of the expression of CD63 molecule on basophil membrane. CD63 is a marker of multivesicular bodies that is exposed to cell membrane during the process of degranulation in which the contents of basophil granules are released. This chapter describes the methodology for performing this assay.
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28315213/enzyme-linked-immunosorbent-assay-elisa
#20
George N Konstantinou
Food allergy is a public health concern especially after recognizing its constantly increased prevalence and severity. Despite careful reading of food ingredient statements, food allergic individuals may experience reactions caused by "hidden", "masked", or "contaminated" proteins that are known major allergens. Many techniques have been developed to detect even small traces of food allergens, for clinical or laboratory purposes. Enzyme-linked immunosorbent assay (ELISA) is one of the best validated and most routinely used immunoassay in allergy research, in allergy diagnosis in allergy-related quality control in various industries...
2017: Methods in Molecular Biology
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