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J Liu, S-K Zhang, J-M Luo, Q-Z Hu, W-Y Ma, S-Z Wu
OBJECTIVE:   To study changes in the cerebrovascular reactivity (CVR) at different altitude area in healthy adults. SUBJECTS AND METHODS: CVR was tested using transcranial Doppler combined with CO2 inhalation, near-infrared spectroscopy (NIRS) was used to detect the regional cerebral oxygen saturation (rScO2). Blood samples were collected, and the vasoactive substances in serum were detected using the enzyme-linked immunosorbent assay. In this study, 59 healthy adults were divided into 3 groups: low altitude group, medium altitude group and high altitude group...
March 2018: European Review for Medical and Pharmacological Sciences
Hiroyuki Yanagisawa, Yukihiko Kudo, Katsuhiro Nakagawa, Haruhiko Miyagawa, Fumitaka Maruyama, Shigehiko Fujimaki
This study was conducted with the aim of achieving the simultaneous screening of various additives in polymer materials by utilizing a solvent-free pyrolyzer/thermal desorption gas chromatography mass spectrometry (Py/TD-GC-MS) method. As a first step to achieve this goal, simultaneous screening has been examined by selecting major substances representing plasticizers and flame retardants, such as short chain chlorinated paraffins (SCCPs), decabromodiphenyl ether (DecaBDE), hexabromocyclododecane (HBCDD), and di(2-ethylhexyl) phthalate (DEHP)...
March 22, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
D Funes-Hernando, M Pelaez-Fernandez, D Winterauer, J-Y Mevellec, R Arenal, T Batten, B Humbert, J L Duvail
This study reports on the plasmon-mediated remote Raman sensing promoted by specially designed coaxial nanowires. This unusual geometry for Raman study is based on the separation, by several micrometres, of the excitation laser spot, on one tip of the nanowire, and the Raman detection at the other tip. The very weak efficiency of Raman emission makes it challenging in a remote configuration. For the proof-of-concept, we designed coaxial nanowires consisting of a gold core to propagate surface plasmon polaritons and a Raman-emitting shell of poly(3,4-ethylene-dioxythiophene)...
March 22, 2018: Nanoscale
Nahed Amri, Tarek Rebai, Neila Jardak, Riadh Badraoui
Our study was designed to evaluate impacts of exposure to pollutants, released by the Gabès-Ghannouche factory complex of phosphate treatment, on biochemical biomarkers and histopathological indices in kidney tissues of Hybrid sparrow (Passer domesticus × Passer hispaniolensis) in Gabès city. Our results show evidence of a pronounced impairment in kidney function which is confirmed by remarkable blood chemical alterations in sparrows living in Ghannouche, the most polluted site. Moreover, superoxide dismutase and catalase activities were found to be decreased in birds sampled from the contaminated site when compared to less polluted areas...
March 21, 2018: Environmental Science and Pollution Research International
De-Ju Cao, Xun Yang, Geng Geng, Xiao-Chun Wan, Ru-Xiao Ma, Qian Zhang, Yue-Gan Liang
A hydroponic experiment was performed to investigate the Cd absorption and subcellular distribution in tea plant, Camellia sinensis. Increased Cd accumulation potential was observed in the tea plant in a Cd-enriched environment, but most of the Cd was absorbed by the roots of C. sinensis. The Cd in all the root fractions was mostly distributed in the soluble fraction, followed by the cell wall fraction. By contrast, the Cd was least distributed in the organelle fraction. The adsorption of Cd onto the C. sinensis roots was described well by the Langmuir isotherm model than the Freundlich isotherm...
March 21, 2018: Environmental Science and Pollution Research International
Soyoung Kwon, Daehoon Han
Experiences of discrimination and mental disorder have been recognized as risks for suicidality. Yet, few studies have examined the direct and indirect effects of discrimination on suicidal ideation through mental disorder among Latino adults in the U.S. This study aimed to examine whether everyday discrimination and racial/ethnic discrimination is associated with suicidal ideation and if mental disorder (i.e., DSM-IV depressive, anxiety, and substance use) mediates the association. Discrimination was operationalized with self-reported discriminatory experience...
March 21, 2018: Journal of Immigrant and Minority Health
Yanghao Shen, Xinyan Zheng, Xiaoyu Wang, Tieshan Wang
Microorganisms play a significant role in uranium(VI) biogeochemistry and influence U(VI) transformation through biomineralization. In the present work, the process of uranium mineralization was investigated by Saccharomyces cerevisiae. The toxicity experiments showed that the viability of cell was not significantly affected by 100 mg L-1 U(VI) under 4 days of exposure time. The batch experiments showed that the phosphate concentration and pH value increased over time during U(VI) adsorption. Meanwhile, thermodynamic calculations demonstrated that the adsorption system was supersaturated with respect to UO2 HPO4 ...
March 21, 2018: Applied Microbiology and Biotechnology
Dino Miraglia, David Ranucci, Massimo Trabalza-Marinucci, Gabriele Acuti, Claudio Forte, Michela Codini, Rossana Roila, Raffaella Branciari
This study aimed at evaluating the effect of Oregano vulgaris extract supplementation of heavy pig diet on the microbiological, chemical-physical and sensory characteristics of Fabriano salami. Fabriano salamis were produced processing meat derived from pigs belonging to two dietary groups of 16 pigs each: CTRL group fed a commercial pelleted feed, and OR group fed the CTRL diet integrated with 0.2% of oregano extract. Ten salamis per group were collected at 0, 7, 20 and 45 days of ripening and analysed for total viable count, enumeration of Enterobacteriaceae , Enterococcus spp, coagulase negative and positive staphylococci, Lactobacillus spp...
October 20, 2017: Italian Journal of Food Safety
Lucie D Cluver, Franziska Meinck, Janina I Steinert, Yulia Shenderovich, Jenny Doubt, Rocio Herrero Romero, Carl J Lombard, Alice Redfern, Catherine L Ward, Sibongile Tsoanyane, Divane Nzima, Nkosiyapha Sibanda, Camille Wittesaele, Sachin De Stone, Mark E Boyes, Ricardo Catanho, Jamie McLaren Lachman, Nasteha Salah, Mzuvukile Nocuza, Frances Gardner
Objective: To assess the impact of 'Parenting for Lifelong Health: Sinovuyo Teen', a parenting programme for adolescents in low-income and middle-income countries, on abuse and parenting practices. Design: Pragmatic cluster randomised controlled trial. Setting: 40 villages/urban sites (clusters) in the Eastern Cape province, South Africa. Participants: 552 families reporting conflict with their adolescents (aged 10-18)...
2018: BMJ Global Health
Soon Woo Park, Young Joong Kang, Huisu Eom, Hyun-Jin Cho, Jungho Ahn, Sang-Gil Lee
Background: The olfactory bulb is anatomically exposed and thus can be directly damaged by external stimulation. This can occur as an occupational injury owing to contact with organic solvents or other causes. We present cases of eight patients who sustained occupation-related exposure to potentially toxic substances and later presented with signs and symptoms of anosmia. We examined the occupational and medical characteristics of the patients and evaluated their work-relatedness. Case presentation: Case 1: A 50-year-old man performed high-frequency heat treatments for approximately 11 years...
2018: Annals of Occupational and Environmental Medicine
Reem Jarrad, Sawsan Hammad, Tagreed Shawashi, Naser Mahmoud
Aim: This study aimed to detect if there were differences in compassion fatigue (CF) among nurses based on substance use and demographic variables of gender, marital status, type of health institution and income. Background: Compassion fatigue is considered an outcome of poorly handled stressful situations in which nurses may respond with self-harming behaviours like substance use. Evidence in this area is critically lacking. Methods: This study used a descriptive design to survey differences in CF of 282 nurses...
2018: Annals of General Psychiatry
Takuya Hirose, Ippei Suzuki, Naoki Takahashi, Toshiyuki Fukada, Prasarn Tangkawattana, Kazushige Takehana
Ehlers-Danlos syndrome (EDS) is a group of hereditary diseases caused by mutation of extracellular matrix-related genes. Recently, spondylodysplastic EDS-Zip13 (spEDS-Zip13: OMIM 612350) was recognized as a new EDS type. This current study could reveal various morphometric differences of collagenous population in the proper substance of cornea between the wild type and spEDS-Zip13-knockout (Zip13-KO) mice. Blockade of Smad-signaling pathway might initiate these alterations. Predilected dissimilarity in level of transcriptional activity probably dictated morphology of keratocyte and shape and electron density of its nucleus...
March 22, 2018: Journal of Veterinary Medical Science
Ichiro Higashikubo, Heihachiro Arito, Kenji Ando, Akihiro Araki, Hidesuke Shimizu, Haruhiko Sakurai
OBJECTIVES: This study aimed to assess workers' exposure to indium and its compounds in 55 indium-handling operations among 13 Japanese plants. The surveyed plants were selected from indium-manufacturing plants whose annual indium production exceeded 500 kg. METHODS: The Control of Substances Hazardous to Health (COSHH) Essentials control banding toolkit, which contains simple scales for hazard levels, quantities in daily use, and "dustiness" characteristics, was used to assess generic risks of indium-handling operations...
March 20, 2018: Journal of Occupational Health
Elke Tatjana Aristizabal Prada, Vera Heinzle, Thomas Knösel, Svenja Nölting, Gerald Spoettl, Julian Maurer, Christine Spitzweg, Martin Angele, Nina Schmidt, Felix Beuschlein, Günter K Stalla, Rainer Blaser, Klaus A Kuhn, Christoph J Auernhammer
Tropomyosin receptor kinase (Trk) inhibitors are investigated as a novel targeted therapy in various cancers. We investigated the in vitro effects of the pan-Trk inhibitor GNF-5837 in human neuroendocrine tumor (NET) cells. The human neuroendocrine pancreatic BON1, bronchopulmonary NCI-H727 and ileal GOT1 cell lines were treated with GNF-5837 alone and in combination with everolimus. Cell viability decreased in a time- and dose-dependent manner in GOT1 cells in response to GNF-5837 treatment, while treatment in BON1 and NCI-H727 cells showed no effect on cellular viability...
March 21, 2018: Endocrine-related Cancer
Zhouyang Li, Yinfang Wu, Haipin Chen, Chen Zhu, Lingling Dong, Yong Wang, Huiwen Liu, Xuchen Xu, Jiesen Zhou, Yanping Wu, Wen Li, Songmin Ying, Huahao Shen, Zhihua Chen
Increasing toxicological and epidemiological studies have demonstrated that ambient particulate matter (PM) could cause adverse health effects including inflammation in the lung. Alveolar macrophages represent a major type of innate immune responses to foreign substances. However, the detailed mechanisms of inflammatory responses induced by PM exposure in macrophages are still unclear. We observed that coarse PM treatment rapidly activated mechanistic target of rapamycin (MTOR) in mouse alveolar macrophages in vivo, and in cultured mouse bone marrow-derived macrophages, mouse peritoneal macrophages, and RAW264...
March 21, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
Kelly K Anderson, Ross Norman, Arlene G MacDougall, Jordan Edwards, Lena Palaniyappan, Cindy Lau, Paul Kurdyak
OBJECTIVE: There is a dearth of information on people with first-episode psychosis who do not access specialized early psychosis intervention (EPI) services. We sought to estimate the proportion of incident cases of nonaffective psychosis that do not access these services and to examine factors associated with EPI admission. METHODS: Using health administrative data, we constructed a retrospective cohort of incident cases of nonaffective psychosis in the catchment area of the Prevention and Early Intervention Program for Psychoses (PEPP) in London, Ontario, between 1997 and 2013...
January 1, 2018: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
Yifu Xu, Bin Yan, Jian Chen, Lei Zeng, Lei Li
BACKGROUND: Dual-energy computed tomography (DECT) has been widely used to improve identification of substances from different spectral information. Decomposition of the mixed test samples into two materials relies on a well-calibrated material decomposition function. OBJECTIVE: This work aims to establish and validate a data-driven algorithm for estimation of the decomposition function. METHODS: A deep neural network (DNN) consisting of two sub-nets is proposed to solve the projection decomposition problem...
March 15, 2018: Journal of X-ray Science and Technology
Marie-Charlotte Gandolphe, Bérénice Lecluyse, Claire Triquet, Emmanuel Brunelle, Jean-Paul Duparcq, Jean-Louis Nandrino
OBJECTIVES: Impairments in social cognition have been described as playing a major role in the maintenance of addictive behavior in substance abusers. This study aimed to investigate the Theory of Mind (ToM) ability of opiate-dependent (OD) patients and to explore whether TOM ability was correlated with length of substance abuse, age at onset of substance abuse and length of abstinence. METHODS: OD patients (N = 29) and non-dependent individuals (NDI) (N = 29) were submitted to the Theory of Mind Assessment Scale (Th...
March 12, 2018: Comprehensive Psychiatry
Biljana K Tubić, Sandra S Vladimirov, Bojan D Marković, Tibor J Sabo
O,O'-diethyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate (DE-EDCP) is novel substance with cytotoxic activity in human leukemic cells. The aim of this study has been to predict in vivo bioavailability of the DE-EDCP and its potential metabolite (S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoic acid (EDCP) by in vitro characterization which includes determination of lipophilicity and passive membrane permeability. There has also been evaluated inter-laboratory reproducibility of the bio-analytical method which was previously developed and validated for non-clinical study of the DE-EDCP and EDCP...
March 2018: Acta Chimica Slovenica
Nancy A Gonzales, Michaeline Jensen, Jenn Yun Tein, Jessie J Wong, Larry E Dumka, Anne Marie Mauricio
Importance: Substance abuse preventive interventions frequently target middle school students and demonstrate efficacy to prevent early onset and use of alcohol and illicit drugs. However, evidence of sustained results to prevent later patterns of alcohol misuse and more serious alcohol abuse disorders has been lacking, particularly for US Latino populations. Objective: To test whether a universal middle school prevention program can reduce the frequency of alcohol misuse and rates of alcohol use disorder 5 years after implementation with a Mexican American sample...
March 21, 2018: JAMA Psychiatry
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