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https://www.readbyqxmd.com/read/28730909/dramatic-response-of-acute-disseminated-intravascular-coagulation-to-erlotinib-in-a-patient-with-lung-adenocarcinoma-with-activating-egfr-mutation
#1
Jung Soo Kim, Jeong-Seon Ryu, Sang Hoon Jeon, Hyun-Jung Kim, Hae-Seong Nam, Jae Hwa Cho, Seung Min Kwak, Hong Lyeol Lee
Disseminated intravascular coagulation (DIC) is a commonly encountered clinical situation characterized by thrombotic occlusion or bleeding in patients with lung cancer. DIC in patients with cancer is usually asymptomatic, taking a chronic form as a compensatory mechanism. Although acute DIC in patients with lung cancer is rarely reported, it can be fatal. We herein describe a patient with lung adenocarcinoma with an activating mutation of the epidermal growth factor receptor (EGFR) gene who developed acute DIC after minor surgical excision...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28729640/radiation-induced-liver-disease-current-understanding-and-future-perspectives
#2
REVIEW
Jieun Kim, Youngmi Jung
Although radiotherapy (RT) is used for the treatment of cancers, including liver cancer, radiation-induced liver disease (RILD) has emerged as a major limitation of RT. Radiation-induced toxicities in nontumorous liver tissues are associated with the development of numerous symptoms that may limit the course of therapy or have serious chronic side effects, including late fibrosis. Although the clinical characteristics of RILD patients have been relatively well described, the understanding of RILD pathogenesis has been hampered by a lack of reliable animal models for RILD...
July 21, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28729429/brain-perfusion-imaging-under-acetazolamide-challenge-for-detection-of-impaired-cerebrovascular-reserve-capacity-positive-findings-with-o-15-water-pet-in-patients-with-negative-tc-99m-hmpao-spect
#3
Güliz Acker, Catharina Lange, Imke Schatka, Andreas Pfeifer, Marcus A Czabanka, Peter Vajkoczy, Ralph Buchert
Cerebrovascular reserve capacity (CVRC) is an important parameter for treatment decisions in chronic cerebrovascular diseases. It can be assessed by measuring the acetazolamide-induced change of regional cerebral blood flow using single photon emission computed tomography (SPECT) with Tc-99m-labeled hexamethylpropyleneamine oxime (HMPAO) or positron emission tomography (PET) with O-15-water. Methods: Our database was searched for patients with moyamoya vasculopathy (MMV) or atherosclerotic cerebrovascular disease who had underwent O-15-water PET after normal Tc-99m-HMPAO SPECT with respect to CVRC...
July 20, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28728828/obstruction-of-peritoneal-dialysis-catheter-is-associated-with-catheter-type-and-independent-of-omentectomy-a-comparative-data-analysis-from-a-transplant-surgical-and-a-pediatric-surgical-department
#4
Josephine Radtke, Raphael Schild, Marc Reismann, Robert-Richard Ridwelski, Caroline Kempf, Bjoern Nashan, Karin Rothe, Martina Koch
BACKGROUND: Peritoneal dialysis (PD) catheter occlusion is a common complication with up to 36% of catheter obstructions described in the literature. We present a comparison of complications and outcome after implantation of PD catheters in a transplant surgical and a pediatric surgical department. METHODS: We retrospectively analyzed 154 PD catheters, which were implanted during 2009-2015 by transplant surgeons (TS, University Medical Center Hamburg-Eppendorf, Germany, n=85 catheters) and pediatric surgeons (PS, Charité University Medicine Berlin, Germany, n=69 catheters) in 122 children (median (range) age 3...
July 4, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28724418/improved-recovery-of-regional-left-ventricular-function-after-pci-of-chronic-total-occlusion-in-stemi-patients-a-cardiovascular-magnetic-resonance-study-of-the-randomized-controlled-explore-trial
#5
Joëlle Elias, Ivo M van Dongen, Loes P Hoebers, Dagmar M Ouweneel, Bimmer E P M Claessen, Truls Råmunddal, Peep Laanmets, Erlend Eriksen, René J van der Schaaf, Dan Ioanes, Robin Nijveldt, Jan G Tijssen, Alexander Hirsch, José P S Henriques
BACKGROUND: The Evaluating Xience and left ventricular function in PCI on occlusiOns afteR STEMI (EXPLORE) trial did not show a significant benefit of percutaneous coronary intervention (PCI) of the concurrent chronic total occlusion (CTO) in ST-segment elevation myocardial infarction (STEMI) patients on global left ventricular (LV) systolic function. However a possible treatment effect will be most pronounced in the CTO territory. Therefore, we aimed to study the effect of CTO PCI compared to no-CTO PCI on the recovery of regional LV function, particularly in the CTO territory...
July 19, 2017: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/28722815/influence-of-morphine-and-naloxone-on-pain-modulation-in-rheumatoid-arthritis-chronic-fatigue-syndrome-fibromyalgia-and-controls-a-double-blind-randomized-placebo-controlled-cross-over-study
#6
Linda Hermans, Jo Nijs, Patrick Calders, Luc De Clerck, Greta Moorkens, Guy Hans, Sofie Grosemans, Tine Roman De Mettelinge, Joanna Tuynman, Mira Meeus
BACKGROUND: Impaired pain inhibitory and enhanced pain facilitatory mechanisms are repeatedly reported in patients with central sensitization pain. However, the exact effects of frequently prescribed opioids on central pain modulation are still unknown. METHODS: A randomized, double-blind, placebo-controlled cross-over trial was carried out. Ten CFS/FM patients, 11 RA patients and 20 controls were randomly allocated to the experimental (10 mg morphine or 0.2 mg/ml Naloxone) and placebo (2 ml Aqua) group...
July 19, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28722455/-hidradenitis-suppurativa-symptoms-diagnostics-and-therapy
#7
Monika Arenbergerová, Robert Artur Dahmen, Petr Arenberger
Hidradenitis suppurativa is a chronic skin disorder characterized by recurrent inflammatory nodules, fistulas, abscesses, and scarring mainly in the intertriginous areas with terminal hair and apocrine glands. Hidradenitis suppurativa manifests usually after puberty, in the third life decade and persists for many years. The prevalence of the disease is estimated to be 0,5 % in the Czech Republic. Women are most often affected in the axillary and inguinal parts, while men in the perianal and gluteal areas. The exact pathogenesis is still unknown...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28719802/cerebral-hypoperfusion-is-not-associated-with-an-increase-in-%C3%AE-amyloid-pathology-in-middle-aged-or-elderly-people
#8
O Hansson, S Palmqvist, H Ljung, T Cronberg, D van Westen, R Smith
INTRODUCTION: It is hypothesized that cerebral hypoperfusion promotes the development of Alzheimer pathology. We therefore studied whether longstanding cerebral hypoperfusion is associated with Alzheimer pathology in nondemented humans. METHODS: Cerebral blood flow and β-amyloid ((18)F-Flutemetamol) positron emission tomography retention were assessed in eleven patients with unilateral occlusion of precerebral arteries resulting in chronic and uneven hypoperfusion...
July 15, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28717436/endovascular-management-of-chronic-internal-carotid-occlusion-with-penumbra-system
#9
Masoud Mehrpour
No abstract text is available yet for this article.
January 5, 2017: Iranian Journal of Neurology
https://www.readbyqxmd.com/read/28716335/management-of-chronic-total-coronary-occlusion-in-stable-ischemic-heart-disease-by-percutaneous-coronary-intervention-versus-coronary-artery-bypass-grafting-versus-medical-therapy
#10
Mony Shuvy, Feng Qiu, Alyssandra Chee-A-Tow, John J Graham, Wael Abuzeid, Christopher Buller, Bradley H Strauss, Harindra C Wijeysundera
Coronary chronic total occlusions (CTOs) are found in approximately 20% of angiograms. We sought to assess the variation in the management of patients with CTOs and to compare the clinical outcomes of CTO lesions with those of non-CTO lesions. We conducted a population-based cohort study and included all patients with stable angina who underwent cardiac catheterization from October 1, 2012, to June 30, 2013, in Ontario, Canada. The primary outcome was a composite of mortality and hospitalization for myocardial infarction...
June 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28715608/ticagrelor-mitigates-ischemia-reperfusion-induced-vascular-endothelial-dysfunction-in-healthy-young-males-a-randomised-single-blinded-study
#11
Stefan Weisshaar, Brigitte Litschauer, Matthias Eipeldauer, Eva Luise Hobl, Michael Wolzt
AIM: Animal data suggest that ticagrelor but not clopidogrel protects against tissue injury. It is unclear if this effect of ticagrelor is also detectable in humans. We studied the effect of ticagrelor and clopidogrel at standard clinical doses on endothelial dysfunction in an experimental model of forearm vascular ischemia-reperfusion (IR) injury. METHODS: In a randomised, single-blinded trial 24 subjects underwent forearm blood flow (FBF) measurements in response to the endothelium-dependent vasodilator acetylcholine (ACh) and to glyceryltrinitrate (GTN; endothelium-independent) before and after a 20 min forearm ischemia...
July 17, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28715513/percutaneous-endovascular-treatment-of-infrainguinal-paod-results-of-the-psi-register-study-in-74%C3%A2-german-vascular-centers
#12
C-A Behrendt, F Heidemann, K Haustein, R T Grundmann, E S Debus
BACKGROUND: The percutaneous infrainguinal stent (PSI) register study aimed to collate all percutaneous endovascular procedures for infrainguinal peripheral arterial occlusive disease (PAOD) conducted in 74 German vascular centers between September and November 2015 (3 months). In order to obtain representative results all consecutive treatment procedures had to be submitted by the participating trial centers. MATERIAL AND METHODS: This was a prospective, nonrandomized multicenter study design...
2017: Gefässchirurgie: Zeitschrift Für Vaskuläre und Endovaskuläre Chirurgie
https://www.readbyqxmd.com/read/28711531/transdural-indocyanine-green-videography-for-sta-mca-bypass-technical-note
#13
Hiroshi Yokota, Taiji Yonezawa, Tomonori Yamada, Seisuke Miyamae, Taekyun Kim, Yoshiaki Takamura, Katsuya Masui, Shuta Aketa
BACKGROUND: Neurosurgical application of indocyanine green (ICG) videography prior to performing a dural opening has been reported as transdural ICG videography and used during surgery of meningiomas associated with venous sinuses, as well as cranial and spinal arteriovenous malformations. However, its use for a superficial temporal artery to middle cerebral artery (STA-MCA) bypass has not been reported. METHODS: We performed a retrospective analysis of medical records of patients who underwent a transdural ICG videography technique during STA-MCA bypass procedures performed between January 2012 and March 2015...
July 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28710988/intestinal-fatty-acid-binding-protein-level-as-a-predictor-of-28-day-mortality-and-bowel-ischemia-in-patients-with-septic-shock-a-preliminary-study
#14
Motohiro Sekino, Hiroyuki Funaoka, Shuntaro Sato, Kyoko Okada, Haruka Inoue, Rintaro Yano, Sojiro Matsumoto, Taiga Ichinomiya, Ushio Higashijima, Shuhei Matsumoto, Tetsuya Hara
PURPOSE: We sought to evaluate the levels of intestinal fatty acid-binding protein (I-FABP), a biomarker of enterocyte injury, as a predictor of 28-day mortality and bowel ischemia in septic shock patients. MATERIAL AND METHODS: In this preliminary prospective observational study, 57 adult septic shock patients under mechanical ventilation were enrolled. Serum I-FABP levels and prognostic biomarkers were recorded upon intensive care unit (ICU) admission. RESULTS: The overall 28-day mortality rate of participants was 23% (13/57)...
July 6, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28710306/ruxolitinib-treatment-in-an-infant-with-jak2-polycythaemia-vera-associated-budd-chiari-syndrome
#15
Mehmet Enes Coskun, Sue Height, Anil Dhawan, Nedim Hadzic
Budd-Chiari syndrome (BCS) is caused by hepatic venous outflow obstruction commonly seen with myeloproliferative neoplasms (MPNs). Polycythaemia vera (PV) is a very rare MPN in childhood. This is the youngest reported patient diagnosed with PV and BCS secondary to JAK V617F mutation.A 26-month-old girl was admitted with a 5-month history of abdominal distension, hepatosplenomegaly and ascites. Imaging studies revealed occlusion of the right hepatic vein and marked attenuation of the middle and left hepatic veins...
July 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28707544/differentiation-of-chronic-total-occlusion-and-sub-total-occlusion-of-the-femoropopliteal-artery-role-of-retrograde-flow-sign-and-collateral-circulation-on-ct-angiography-images
#16
Shujun Zhang, Yanfei Su, Haisong Chen
OBJECTIVE: To study the value of a retrograde flow sign and the collateral circulation on computed tomography angiography (CTA) for the differential diagnosis of chronic total occlusion from sub-total occlusion of the femoropopliteal artery (FPA). METHODS: Fifty patients with obstruction of the FPA underwent CTA and digital subtraction angiography (DSA) examinations of the lower limbs. The frequency of a retrograde flow sign and collateral circulation on CTA in chronic total and sub-total occlusion was noted and analyzed, with the results of DSA as a standard to judge total or sub-total occlusion...
July 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28707316/ticagrelor-and-absorb-bioresorbable-vascular-scaffold-implantation-for-recovery-of-vascular-function-after-successful-chronic-total-occlusion-recanalization-tiger-bvs-trial-rationale-and-study-design
#17
Salvatore Brugaletta, Josep Gomez-Lara, Juan Caballero, Luis Ortega-Paz, Luis Teruel, Miriam Jimenez Fernandez, Rafael Romaguera, Vicente Alcalde Martinez, Marcos Ñato, Eduardo Molina Navarro, Joan-Antoni Gomez-Hospital, Concepcion Correa Vilches, Maria Joyera, Angel Cequier, Manel Sabate
OBJECTIVES: To explore the role of ticagrelor versus clopidogrel in coronary blood flow normalization immediately after chronic coronary total occlusion (CTO) recanalization. BACKGROUND: Coronary vascular function of a CTO immediately after recanalization is demonstrated to be poor. METHODS: The TIGER BVS is a prospective, double-randomized, open-label, two parallel-group controlled clinical trial to evaluate efficacy of ticagrelor versus clopidogrel in improving vascular function of coronary segment distal to CTO immediately after CTO recanalization...
July 14, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28707308/baseline-anemia-in-patients-undergoing-percutaneous-coronary-intervention-after-an-acute-coronary-syndrome-a-paradox-of-high-bleeding-risk-high-ischemic-risk-and-complex-coronary-disease
#18
Khaled Yazji, Fairoz Abdul, Senthil Elangovan, Muhammad Z Ul Haq, Nick Ossei-Gerning, Keith Morris, Richard Anderson, Tim Kinnaird
OBJECTIVES: To define more clearly the associations between baseline anemia, bleeding/ischemia risk, coronary disease severity, and outcomes by revascularization completeness. BACKGROUND: Anemia is associated with adverse outcomes in patients presenting with an acute coronary syndrome (ACS). METHODS AND RESULTS: Data was sourced from hospital databases for patients admitted with an ACS to a single center between 2011 and 2014. Using WHO anemia criteria, 468 (26...
July 13, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28705343/-recanalization-procedure-of-the-common-femoral-vein-following-iatrogenic-femoral-chronic-occlusion-3%C3%A2-cases
#19
G Goudot, C Del Giudice, O Pellerin, M C Courtois, A Galloula, E Messas, T Mirault, M Sapoval
Common femoral vein occlusion (CFVO) is frequently found in patients with chronic venous insufficiency. The iatrogenic form, secondary to either central catheter or surgery, is very rare but highly symptomatic. Classical compression therapy barely improves the clinical status of these patients, making them suitable candidates for an interventional procedure for venous recanalization. METHODS: We report here three consecutive cases of iatrogenic CFVO referred to our outpatient clinic because the disease had an impact on daily life activities...
July 2017: J Med Vasc
https://www.readbyqxmd.com/read/28705045/percutaneous-coronary-interventions-of-chronic-total-occlusions-a-review-of-clinical-indications-treatment-strategy-and-current-practice
#20
Johan Bennett, Peter Kayaert, Yoann Bataille, Jo Dens
Chronic total occlusions (CTOs) are commonly encountered in patients undergoing coronary angiography, but percutaneous coronary intervention (PCI) for CTO is currently infrequently performed owing to the perception of limited clinical benefit, high complexity and cost of intervention, and perceived risk of complications. Numerous observational studies have demonstrated that successful CTO revascularization is associated with better cardiovascular outcomes and enhanced quality of life (QOL). However, in the absence of randomized trials, its prognostic benefit remains debated...
July 14, 2017: Acta Cardiologica
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