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https://www.readbyqxmd.com/read/29668120/cytomegalovirus-infection-in-living-donor-liver-transplant-recipients-significantly-impacts-the-early-post-transplant-outcome-a-single-center-experience
#1
Sanjay Kumar Yadav, Sanjiv Saigal, Narendra Singh Choudhary, Sujeet Saha, Jayant Kumar Sah, Neeraj Saraf, Naveen Kumar, Sanjay Goja, Amit Rastogi, Prashant Bhangui, A S Soin
BACKGROUND: Cytomegalovirus (CMV) is the most common viral infection in liver transplant recipients that influences the outcomes of liver transplantation. However, its impact on early outcomes following living donor liver transplantation (LDLT) is not fully defined in the Indian subcontinent. This study was done to assess the impact of CMV infection on early post-transplant outcomes in LDLT recipients. METHODS: Out of 272 LDLTs performed from January 2012 to April 2013, 151 recipients underwent CMV viral load analysis in plasma within 90 days post LDLT based on clinical suspicion...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29667813/a-sensitive-water-soluble-reversible-optical-probe-for-hg-2-detection
#2
Sayani Das, Anindita Sarkar, Ananya Rakshit, Ankona Datta
We report the serendipitous discovery of an optical mercury sensor while trying to develop a water-soluble manganese probe. The sensor is based on a pentaaza macrocycle conjugated to a hemicyanine dye. The pentaaza macrocycle earlier designed in our group was used to develop photoinduced electron transfer (PET)-based "turn-on" fluorescent sensors for manganese. (1) In an attempt to increase the water-solubility of the manganese sensors we changed the dye from BODIPY to hemicyanine. The resultant molecule qHCM afforded a distinct reversible change in the absorption features and a concomitant visible color change upon binding to Hg2+ ions, leading to a highly water-soluble mercury sensor with a 10 ppb detection limit...
April 18, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29665076/life-threatening-or-nearly-life-threatening-complications-in-living-liver-donors
#3
Asim Onur, Sami Akbulut, Abuzer Dirican, Burak Isik, Sezai Yilmaz
OBJECTIVE: To determine the relationship between a transplant center's experience and life-threatening or nearly life-threatening complications during living donor hepatectomy (LDH). METHODS: The medical records of 1140 patients who underwent LDH were analyzed. In order to determine the relationship between life-threatening complications and a transplant center's experience, the following comparisons between LDH cases were done: first 100 vs subsequent 100; first 100 vs subsequent 1040; first 200 vs subsequent 940; right hepatectomy vs left hepatectomy, and first 5 years of experience vs subsequent 5 years...
April 17, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29664201/rare-blood-donor-needed
#4
Richard R Gammon, Harold Alvarez, Nancy Benitez
BACKGROUND: Here, we describe a 14-year-old male with leukocyte adhesion deficiency type 2 who was transferred to a university hospital with anemia (hemoglobin 6 g/dL) and multiple singular abscesses refractory to antimicrobials. CASE REPORT: As leukocyte adhesion deficiency type 2 is associated with Bombay phenotype, the patient's red blood cells (RBCs) were tested with commercial anti-H lectin Ulex europaeus. An allogeneic adsorption with phenotype-matched cells was performed...
April 17, 2018: Transfusion
https://www.readbyqxmd.com/read/29663565/risk-factors-for-early-invasive-fungal-infections-in-pediatric-liver-transplant-recipients
#5
Yehonatan Pasternak, Shiri Rubin, Efraim Bilavsky, Yael Mozer-Glassberg, Itzhak Levy, Elhanan Nahum, Eran Rom, Michael Gurevich, Haim Ben-Zvi, Liat Ashkenazi-Hoffnung
BACKGROUND: Invasive fungal infections (IFIs) post-liver transplantation are a frequent cause of morbidity and mortality;however, studies reporting on these infections in the pediatric population are scarce. OBJECTIVE: To investigate the incidence and risk factors of IFIs in pediatric liver transplant recipients during the early post-transplantation period (≤3 months). MATERIALS AND METHODS: Data were collected for all pediatric liver transplant recipients registered in a national transplantation center from 2004-2014...
April 17, 2018: Mycoses
https://www.readbyqxmd.com/read/29663498/hand-assisted-laparoscopic-retroperitoneal-donor-nephrectomy-a-single-institution-experience-of-over-500-cases-operative-technique-and-clinical-outcomes
#6
Sanjaya Kumar, Russell G Witt, Stefan G Tullius, Sayeed K Malek
OBJECTIVE: Although there are several variations of laparoscopic living donor nephrectomies, there is no consensus as to the best technique. Our objective was to describe our technique and assess the outcomes of our approach to hand-assisted laparoscopic retroperitoneal donor nephrectomies. METHODS: From July 2001 to October 2015, 507 consecutive hand-assisted laparoscopic retroperitoneal donor nephrectomies were performed. Their clinical information was retrospectively reviewed including warm ischemia time, skin incision to kidney ready time, estimated blood loss, adverse intraoperative events, and postoperative complications...
April 17, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29662679/validation-of-living-donor-nephrectomy-codes
#7
Ngan N Lam, Krista L Lentine, Scott Klarenbach, Manish M Sood, Paul J Kuwornu, Kyla L Naylor, Gregory A Knoll, S Joseph Kim, Ann Young, Amit X Garg
Background: Use of administrative data for outcomes assessment in living kidney donors is increasing given the rarity of complications and challenges with loss to follow-up. Objective: To assess the validity of living donor nephrectomy in health care administrative databases compared with the reference standard of manual chart review. Design: Retrospective cohort study. Setting: 5 major transplant centers in Ontario, Canada...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29661466/endobronchial-topical-amphotericin-b-instillation-for-pulmonary-chromomycosis-after-lung-transplantation-a-case-report
#8
H Mitomo, A Sakurada, Y Matsuda, H Notsuda, T Watanabe, H Oishi, H Niikawa, S Maeda, M Noda, T Sado, T Amemiya, Y Yoshida, T Kikuchi, K Kamei, Y Okada
We report a very rare case of pulmonary chromomycosis caused by Scedosporium prolificans that developed after lung transplantation and was successfully treated with endobronchial topical amphotericin B instillation. The subject was a woman in her 50s with a history of bilateral lobar lung transplantation from living donors for idiopathic pulmonary hypertension. Eight years after the lung transplantation, chest radiography X-ray and computed tomography showed an abnormal shadow in the right lung. Bronchoscopic findings showed obstruction by a fungal component at the laterobasal bronchus B9...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29661461/urgent-living-donor-liver-transplantation-in-a-patient-with-concurrent-active-tuberculosis-a-case-report
#9
B-H Jung, J-I Park, S-G Lee
BACKGROUND: Although active tuberculosis (TB) is considered a contraindication for liver transplantation (LT), this is the only treatment in patients with liver failure and concurrent active TB. We report a case with successful urgent living-donor LT for irreversible liver failure in the presence of active TB. CASE PRESENTATION: A 48-year-old man, with a history of decompensated alcoholic liver cirrhosis, was presented with stupor. At admission, his consciousness had deteriorated to semi-coma, and his renal function also rapidly deteriorated to hepatorenal syndrome...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29661433/better-selection-criteria-with-prognostic-factors-for-liver-transplantation
#10
L S Nacif, R S Pinheiro, V Rocha-Santos, V M Barbosa, A P de Moura Dias, R B Martino, R A Macedo, L Ducatti, L Haddad, F Galvão, W Andraus, L Carneiro D' Albuquerque
BACKGROUND: Liver transplantation has evolved significantly in recent years, with each advancement part of the effort toward increasing patient and graft survival as well as quality of life. The objective of this study was to evaluate the prognostic factors and selection criteria for liver transplantation. METHODS: Our study was a statistical analysis, logistic regression, and survival evaluation of a total of 80 liver transplants that were performed between June 1, 2016 and September 24, 2016...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29661425/soluble-cd30-acute-rejection-and-graft-survival-pre-and-6-month-post-transplant-determinations-when-is-the-best-time-to-measure
#11
M I de Holanda, T Matuck, D D B M de Carvalho, E M F L Domingues, R Curvo, D S Glasberg, A M G Santos, Á M Borela, L C Pôrto
BACKGROUND: Pretransplantation soluble CD30 (sCD30) has been shown to be a good predictor of acute rejection (AR) and graft loss. This study aimed to evaluate the effectiveness of sCD30 measured pretransplant and up to 6 months after transplantation as a predictor of AR, graft loss, and survival at 5 years post-transplantation. Subjects were patients receiving living donor renal transplants at Bonsucesso Federal Hospital (Rio de Janeiro) in 2006 and between August 2010 and May 2011. METHODS: sCD30 was analyzed in samples collected pretransplantation and 7, 14, and 21, 28 days and 3, 4, 5, and 6 months post-transplantation from 73 kidney recipients...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29661423/living-donor-kidney-transplantation-donor-recipient-function-correlation
#12
I Godinho, J Guerra, M J Melo, M Neves, J Gonçalves, M A Santana, A Gomes da Costa
BACKGROUND: With the rising prevalence of living-donor kidney transplantation, evaluation of factors correlated with renal function in the donor-recipient pair constitutes a main goal for kidney transplantation clinicians. Our objective was to analyze the more relevant donor characteristics that contribute to donor and recipient estimated glomerular filtration rates (eGFR) after 1 year. METHODS: We evaluated 48 consecutive donor-recipient pairs from our unit. RESULTS: Mean donor age was 46 ± 11 years, with 71% being women...
April 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29659397/scintigraphic-and-sonographic-findings-of-subcapsular-cortical-necrosis-in-a-transplanted-kidney
#13
Bulent Yazici, Emrah Gunay, Aysegül Akgün, Sait Sen, Suha Sureyya Ozbek
Renal transplant scintigraphy, performed in a 23-year-old man who had renal graft from a living donor, showed nearly normal perfusion and moderately low function of the graft. But the margins of the graft were blurred, and it was interestingly appearing enlarged late in the study. Ultrasound demonstrated a hypoechoic rim surrounding the whole kidney. Biopsy revealed necrosis besides normal cortical tissue. Necrosis was thought to be limited to the subcapsular cortical area. It should be considered that these scintigraphic findings could be due to greatly reduced and delayed perfusion of edematous subcapsular necrotic area of the graft even in normal perfusion images...
April 13, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29658916/microdissection-of-primary-renal-tissue-segments-and-incorporation-with-novel-scaffold-free-construct-technology
#14
Chase A Arbra, Satish N Nadig, Sarah Grace Dennis, Sanket Pattanaik, Heather A Bainbridge, J Matthew Rhett, Stephen A Fann, Carl Atkinson, Michael J Yost
Kidney transplantation is now a mainstream therapy for end-stage renal disease. However, with approximately 96,000 people on the waiting list and only one-fourth of these patients achieving transplantation, there is a dire need for alternatives for those with failing organs. In order to decrease the harmful consequences of dialysis along with the overall healthcare costs it incurs, active investigation is ongoing in search of alternative solutions to organ transplantation. Implantable tissue-engineered renal cellular constructs are one such feasible approach to replacing lost renal functionality...
March 27, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29652887/ethnicity-matching-and-outcomes-after-kidney-transplantation-in-the-united-kingdom
#15
Bhavini Pisavadia, Adam Arshad, Imogen Chappelow, Peter Nightingale, Benjamin Anderson, Jay Nath, Adnan Sharif
BACKGROUND: Kidneys from non-white donors have inferior outcomes, but it is unclear if ethnicity matching between donors and recipients achieves better post kidney transplant outcomes. METHODS: We undertook a retrospective, population cohort study utilising UK Transplant Registry data. The cohort comprised adult, kidney-alone, transplant recipients receiving their first kidney transplant between 2003-2015, with data censored at 1st October 2016. We included 27,970 recipients stratified into white (n = 23,215), black (n = 1,679) and south Asian (n = 3,076) ethnicity, with median post-transplant follow-up of 1,676 days (IQR 716-2,869 days)...
2018: PloS One
https://www.readbyqxmd.com/read/29651486/coexistence-of-distinct-intramolecular-electron-transfer-pathways-in-polyoxometalate-based-molecular-triads
#16
Yusen Luo, Maria Wächtler, Kevin Barthelmes, Andreas Winter, Ulrich S Schubert, Benjamin Dietzek
Polyoxometalate (POM)-associated charge-separated states, formed by the photoinduced oxidation of a covalently attached photosensitizer and reduction of the POM, have attracted much attention due to the remarkable catalytic properties of the reduced POMs. However, short lifetimes of the POM-associated charge-separated state, which in some cases lead to the backward electron transfer being more rapid than the formation of the charge-separated state itself, are generally observed. Recently, we reported on the first example of a relative long-lived (τ = 470 ns) charge-separated state in a Ru(ii) bis(terpyridine)-POM molecular dyad...
April 13, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29651422/-aspergillus-induced-superoxide-production-by-cystic-fibrosis-phagocytes-is-associated-with-disease-severity
#17
Shan F Brunel, Janet A Willment, Gordon D Brown, Graham Devereux, Adilia Warris
Aspergillus fumigatus infects up to 50% of cystic fibrosis (CF) patients and may play a role in progressive lung disease. As cystic fibrosis transmembrane conductance regulator is expressed in cells of the innate immune system, we hypothesised that impaired antifungal immune responses play a role in CF-related Aspergillus lung disease. Peripheral blood mononuclear cells, polymorphonuclear cells (PMN) and monocytes were isolated from blood samples taken from CF patients and healthy volunteers. Live-cell imaging and colorimetric assays were used to assess antifungal activity in vitro ...
April 2018: ERJ Open Research
https://www.readbyqxmd.com/read/29650376/trapezius-muscle-transfer-for-restoration-of-elbow-extension-in-a-traumatic-brachial-plexus-injury
#18
Hamza M Alrabai, Martin G Gesheff, Ahmed I Hammouda, Janet D Conway
Voluntary elbow extension is essential for optimal upper limb positioning required for daily living activities, particularly above-shoulder maneuvers. The authors present a case of traumatic brachial plexus injury in which paralysis of the musculature selectively supplied by the posterior cord was based on magnetic resonance imaging and nerve conduction studies. An attempt at a radial nerve graft at another center was not effective. Ipsilateral hand function improved after multiple local tendon transfers were performed...
April 9, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29649828/risk-analysis-for-invasive-fungal-infection-after-living-donor-liver-transplantation-which-patient-needs-potent-prophylaxis
#19
Masashi Utsumi, Yuzo Umeda, Takahito Yagi, Takeshi Nagasaka, Susumu Shinoura, Ryuich Yoshida, Daisuke Nobuoka, Takashi Kuise, Tomokazu Fuji, Kosei Takagi, Akinobu Takaki, Toshiyoshi Fujiwara
BACKGROUND: Invasive fungal infection (IFI) is associated with high mortality after living donor liver transplant (LDLT). The aim of this study was to identify the risk factors for post-LDLT IFI for early diagnosis and improvement of antifungal treatment outcome. METHODS: Risk analysis data were available for all 153 patients who underwent LDLT between January 2005 and April 2012. RESULTS: During the follow-up period (1,553 ± 73 days, range 20-2,946 days), 15 patients (9...
April 12, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29649725/production-of-live-fish-derived-from-frozen-germ-cells-via-germ-cell-transplantation
#20
Goro Yoshizaki, Seungki Lee
The conservation of endangered fish is an urgent issue. Although cryo-banking of fish gametes might ultimately help conserve endangered fish, cryopreservation of fish eggs or embryos is still not possible due to their large size and high yolk content. Therefore, as an alternative, we focused on undifferentiated germ cells, such as primordial germ cells, spermatogonia, and oogonia, as materials for cryopreservation. Transplantation of cryopreserved germ cells into the body cavity of allogeneic or xenogeneic recipients sterilized by triploidization or endogenous germ cell ablation resulted in migration of the transplanted germ cells toward the recipient genital ridges, where they were eventually incorporated...
April 3, 2018: Stem Cell Research
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