Felix Gövert, Ligia Abrante, Jos Becktepe, Bettina Balint, Christos Ganos, Ulrich Hofstadt-van Oy, Christos Krogias, James Varley, Sarosh R Irani, Sofija Paneva, Maarten J Titulaer, Juna M de Vries, Agnita J W Boon, Marco W J Schreurs, Bastien Joubert, Jerome Honnorat, Alberto Vogrig, Helena Ariño, Lidia Sabater, Josep Dalmau, Sangeeta Scotton, Saiju Jacob, Nico Melzer, Christian G Bien, Christian Geis, Jan Lewerenz, Harald Prüss, Klaus-Peter Wandinger, Günther Deuschl, Frank Leypoldt
Autoimmune encephalitis can be classified into antibody-defined subtypes, which can manifest with immunotherapy-responsive movement disorders sometimes mimicking non-inflammatory aetiologies. In the elderly, anti-LGI1 and contactin associated protein like 2 (CASPR2) antibody-associated diseases compose a relevant fraction of autoimmune encephalitis. Patients with LGI1 autoantibodies are known to present with limbic encephalitis and additionally faciobrachial dystonic seizures may occur. However, the clinical spectrum of CASPR2 autoantibody-associated disorders is more diverse including limbic encephalitis, Morvan's syndrome, peripheral nerve hyperexcitability syndrome, ataxia, pain and sleep disorders...
February 13, 2023: Brain