Maria Regato-Herbella, Isabel Morhenn, Daniele Mantione, Giuseppe Pascuzzi, Antonela Gallastegui, Ana Beatriz Caribé Dos Santos Valle, Sergio E Moya, Miryam Criado-Gonzalez, David Mecerreyes
Reactive oxygen species (ROS) play a key role in several biological functions like regulating cell survival and signaling; however, their effect can range from beneficial to nondesirable oxidative stress when they are overproduced causing inflammation or cancer diseases. Thus, the design of tailor-made ROS-responsive polymers offers the possibility of engineering hydrogels for target therapies. In this work, we developed thioether-based ROS-responsive difunctional monomers from ethylene glycol/thioether acrylate (EG n SA) with different lengths of the EG n chain ( n = 1, 2, 3) by the thiol-Michael addition click reaction...
February 13, 2024: Chemistry of Materials: a Publication of the American Chemical Society