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https://www.readbyqxmd.com/read/28623473/increasing-the-bile-acid-sequestration-performance-of-cationic-hydrogels-by-using-an-advanced-controlled-polymerization-technique
#1
Patrícia V Mendonça, André Matos, Andreia F Sousa, Arménio C Serra, Sérgio Simões, Jorge F J Coelho
PURPOSE: To investigate the influence of the polymerization technique and the content of hydroxyl groups on the performance of new bile acid sequestrants based on PAMPMTA-co-PHEA (PAMPTMA: poly((3-acrylamidopropyl)trimethylammonium chloride); PHEA: poly(2-hydroxyethyl acrylate)) hydrogels. METHODS: PAMPMTA-co-PHEA hydrogels were prepared using either free radical polymerization or supplemental activator and reducing agent atom transfer radical polymerization. The chemical structure and composition of the hydrogels was confirmed by both FTIR and ssNMR...
June 16, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28614303/bacterial-pathogens-a-spoonful-of-sugar-could-be-the-medicine
#2
Hea-Jin Jung, Eric G Pamer
No abstract text is available yet for this article.
June 14, 2017: Nature
https://www.readbyqxmd.com/read/28590527/phase-transformation-ductilization-of-brittle-high-entropy-alloys-via-metastability-engineering
#3
Hailong Huang, Yuan Wu, Junyang He, Hui Wang, Xiongjun Liu, Ke An, Wei Wu, Zhaoping Lu
High-entropy alloys (HEAs) in which interesting physical, chemical, and structural properties are being continuously revealed have recently attracted extensive attention. Body-centered cubic (bcc) HEAs, particularly those based on refractory elements are promising for high-temperature application but generally fail by early cracking with limited plasticity at room temperature, which limits their malleability and widespread uses. Here, the "metastability-engineering" strategy is exploited in brittle bcc HEAs via tailoring the stability of the constituent phases, and transformation-induced ductility and work-hardening capability are successfully achieved...
June 7, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28578428/surface-modification-of-polyvinylidene-fluoride-pvdf-membrane-via-radiation-grafting-novel-mechanisms-underlying-the-interesting-enhanced-membrane-performance
#4
Liguo Shen, Shushu Feng, Jianxi Li, Jianrong Chen, Fengquan Li, Hongjun Lin, Genying Yu
This study provided the first attempt of grafting hydrophobic polyvinylidene fluoride (PVDF) membrane with hydrophilic hydroxyethyl acrylate (HEA) monomer via a radiation grafting method. This grafted membrane showed an enhanced hydrophilicity (10° decrease of water contact angle), water content ratio, settling ability and wettability compared to the control membrane. Interestingly, filtration tests showed an improved dependence of water flux of the grafted membrane on the solution pH in the acidic stage. Atomic force microscopy (AFM) analysis provided in-situ evidence that the reduced surface pore size of the grafted membrane with the solution pH governed such a dependence...
June 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28528531/diversity-and-distribution-of-ticks-from-domestic-ruminants-in-lebanon
#5
Mayssaa Fawaz Dabaja, Maria Tempesta, Ali Bayan, Gesualdo Vesco, Grazia Greco, Grazia Greco, Alessandra Torina, Valeria Blanda, Francesco La Russa, Salvatore Scimeca, Rossella Lelli, Mohamad Ezzedine, Hussein Mortada, Didier Raoult, Pierre Edouard Fournier, Mohamad Mortada
Ticks (Acari: Ixodidae) are ectoparasites infesting livestock in every geographic area in the world and they are vectors of several viral, bacterial, and protozoan pathogens to animals and humans worldwide. A deep knowledge of the geographical distribution of these arthropods would have a key role in the control of tick-borne diseases. Few data are available about tick presence in domestic ruminants in Lebanon. The study aimed at providing an analysis of tick presence and distribution in Lebanon. Ticks were collected from cattle, sheep, and goats farms distributed in 6 Lebanese provinces between June and September 2014...
April 11, 2017: Veterinaria Italiana
https://www.readbyqxmd.com/read/28516149/dataset-for-acrylate-silica-nanoparticles-formulations-and-photocured-composites-viscosity-filler-dispersion-and-bulk-poisson-s-ratio
#6
Hubert Gojzewski, Mariola Sadej, Ewa Andrzejewska, Martyna Kokowska
UV-curable polymer composites are of importance in industry, biomedical applications, scientific fields, and daily life. Outstanding physical properties of polymer composites were achieved with nanoparticles as filler, primarily in enhancing mechanical strength or barrier properties. Structure-property relationships of the resulting nanocomposites are dictated by the polymer-filler molecular architecture, i.e. interactions between polymer matrix and filler, and high surface area to volume ratio of the filler particles...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28515081/flexible-ammonia-handling-strategies-using-both-cutaneous-and-branchial-epithelia-in-the-highly-ammonia-tolerant-pacific-hagfish
#7
Alexander M Clifford, Alyssa M Weinrauch, Susan L Edwards, Michael P Wilkie, Greg G Goss
Hagfish consume carrion, potentially exposing them to hypoxia, hypercarbia, and high environmental ammonia (HEA). We investigated branchial and cutaneous ammonia handling strategies by which Pacific hagfish (Eptatretus stoutii) tolerate and recover from high ammonia loading. Hagfish were exposed to HEA (20 mmol L(-1)) for 48 h to elevate plasma total ammonia (TAmm) levels before placement into divided chambers for a 4 h recovery period in ammonia-free seawater where ammonia excretion (JAmm) was measured independently in the anterior and posterior compartments...
May 17, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28503455/lesion-characteristics-of-chronic-dysphagia-in-patients-with-supratentorial-stroke
#8
Sol Jang, Hea Eun Yang, Hee Seung Yang, Dae Hyun Kim
OBJECTIVE: To analyze the relationship between brain lesion location and type of chronic dysphagia in patients with supratentorial stroke. METHODS: Data from 82 chronic stroke patients who underwent videofluoroscopic swallowing studies at >6 months after an initial stroke event were retrospectively analyzed. Delayed oral transit time, delayed pharyngeal transit time, and the presence of aspiration were extracted. A voxel-based lesion symptom mapping (VLSM) analysis was used to correlate types of dysphagia with specific brain lesions...
April 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28490714/the-seroprevalence-of-bartonella-henselae-in-healthy-adults-in-korea
#9
Hea Yoon Kwon, Jae Hyoung Im, Sun Myoung Lee, Ji Hyeon Baek, Areum Durey, Shin-Goo Park, Jae-Seung Kang, Jin-Soo Lee
BACKGROUND/AIMS: Cat-scratch disease (CSD), caused by Bartonella henselae is one of the most common zoonosis. However, only several cases of B. henselae infection have been reported in Korea. This study investigated the seroprevalence of B. henselae in healthy adults and related risk factors. METHODS: Serum samples from 300 healthy participants were analyzed using an immunoglobulin G immunof luorescence assay (IFA) for B. henselae isolated in Korea. Surveys on the risk factors for B...
May 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28468622/the-impact-of-production-of-extended-spectrum-%C3%AE-lactamases-on-the-28-day-mortality-rate-of-patients-with-proteus-mirabilis-bacteremia-in-korea
#10
Jin Young Ahn, Hea Won Ann, Yongduk Jeon, Mi Young Ahn, Dong Hyun Oh, Yong Chan Kim, Eun Jin Kim, Je Eun Song, In Young Jung, Moo Hyun Kim, Wooyoung Jeong, Nam Su Ku, Su Jin Jeong, Jun Yong Choi, Dongeun Yong, Young Goo Song, June Myung Kim
BACKGROUND: The incidence of Proteus mirabilis antimicrobial resistance, especially that mediated by extended-spectrum β-lactamases (ESBLs), has increased. We investigated the impact of ESBL production on the mortality of patients with P. mirabilis bacteremia in Korea. METHODS: Patients diagnosed with P. mirabilis bacteremia between November 2005 and December 2013 at a 2000-bed tertiary care center in South Korea were included in this study. Phenotypic and molecular analyses were performed to assess ESBL expression...
May 3, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28449424/fecal-microbiota-transplantation-for-refractory-and-recurrent-clostridium-difficile-infection-a-case-series-of-nine-patients
#11
Byoung Wook Bang, Jin Seok Park, Hyung Kil Kim, Yong Woon Shin, Kye Sook Kwon, Hea Yoon Kwon, Ji Hyeon Baek, Jin Soo Lee
Background/Aims: Fecal microbiota transplantation (FMT) is a highly effective therapy for refractory and recurrent Clostridium difficile infection (CDI). Despite its excellent efficacy and recent widespread use, FMT has not been widely used in South Korea thus far. We describe our experience with FMT to treat refractory/recurrent CDI. Methods: We conducted a chart review of patients who underwent FMT for refractory/recurrent CDI at Inha University Hospital, between March 2014 and June 2016...
April 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/28442260/synthesis-of-benzoxazole-derivatives-as-interleukin-6-antagonists
#12
Darong Kim, Hee Yeon Won, Eun Sook Hwang, Young-Kook Kim, Hea-Young Park Choo
A growing number of studies have demonstrated that interleukin (IL)-6 plays pathological roles in the development of chronic inflammatory disease and autoimmune disease by activating innate immune cells and by stimulating adaptive inflammatory T cells. So, suppression of IL-6 function may be beneficial for prevention and treatment of chronic inflammatory disease. This study reports that a series of synthetic derivatives of benzoxazole have suppressive effects on IL-6-mediated signaling. Among 16 synthetic derivatives of benzoxazole, the compounds 4, 6, 11, 15, 17, and 19 showed a strong suppressive activity against IL-6-induced phosphorylation of signal transducer and activator of transcription (STAT) 3 by 80-90%...
April 7, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28425750/modeling-alloantibody-formation-to-high-incidence-red-blood-cell-antigens-in-immune-responders-using-genotypic-data
#13
Patricia A R Brunker, Keerthana Ravindran, R S Shirey
Alloimmunization to red blood cell antigens is unpredictable and poorly understood. Patients who are negative for high-incidence antigens (HIAs) are at risk for developing the corresponding antibodies. Molecular methods can easily predict the lack of an antigen and thus, the risk of an individual to become immunized. We examined the prevalence and risk factors for HIA alloimmunization in patients at risk based on genotyping results. Genotyping using a molecular method (HEA BeadChip™, Immucor, Warren, NJ) was performed on all patient specimens referred for molecular testing over 45 months; serologic and clinical data were analyzed...
January 2017: Immunohematology
https://www.readbyqxmd.com/read/28409524/natural-course-of-untreated-cluster-headache-a-retrospective-cohort-study
#14
Mi Ji Lee, Hyun Ah Choi, Jong Hwa Shin, Hea Ree Park, Chin-Sang Chung
Objective To determine the natural course of cluster headache. Methods We screened patients with cluster headache who were diagnosed at Samsung Medical Center and lost to follow-up for ≥5 years. Eligible patients were interviewed by phone about the longitudinal changes in headache characteristics and disease course. Remission was defined as symptom-free 1) for longer than twice the longest between-bout period and 2) for ≥5 years. Results Forty-two patients lost to follow-up for mean 7.5 (range, 5.0-15.7) years were included...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28391923/evolutionary-processes-and-sources-of-high-nitrate-haze-episodes-over-beijing-spring
#15
Ting Yang, Yele Sun, Wei Zhang, Zifa Wang, Xingang Liu, Pingqing Fu, Xiquan Wang
Rare and consecutive high-nitrate haze pollution episodes were observed in Beijing in spring 2012. We present detailed characterization of the sources and evolutionary mechanisms of this haze pollution, and focus on an episode that occurred between 15 and 26 April. Submicron aerosol species were found to be substantially elevated during haze episodes, and nitrates showed the largest increase and occupation (average: 32.2%) in non-refractory submicron particles (NR-PM1), which did not occur in other seasons as previously reported...
April 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28391505/bacterial-communities-on-facial-skin-of-teenage-and-elderly-thai-females
#16
Naraporn Somboonna, Alisa Wilantho, Chutika Srisuttiyakorn, Anunchai Assawamakin, Sissades Tongsima
The Human Microbiome Project was first established to understand the roles of human-associated microbes to human health and disease. This study presents preliminary findings of Thai female facial skin microbiome using three pooled samples from groups of skin microbiome profiles, namely (1) healthy and (2) acne-prone young adults (teenage.hea and teenage.acn) and (3) healthy elderly adults (elderly.hea) based on standard dermatological criteria. These samples were sequenced using 454-pyrosequencing targeting 16S rRNA (V3-V4 regions)...
April 8, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28389094/monoclonal-antibody-fragment-removal-mediated-by-mixed-mode-resins
#17
Ellen O'Connor, Matthew Aspelund, Frank Bartnik, Mark Berge, Kelly Coughlin, Mutsa Kambarami, David Spencer, Huiming Yan, William Wang
Efforts to increase monoclonal antibody expression in cell culture can result in the presence of fragmented species requiring removal in downstream processing. Capto adhere, HEA Hypercel, and PPA Hypercel anion exchange/hydrophobic interaction mixed mode resins were evaluated for their fragment removal capabilities and found to separate large hinge IgG1 antibody fragment (LHF) from monomer. Removal of greater than 75% of LHF population occurred at pH 8 and low conductivity. The mechanism of fragment removal was investigated in two series of experiments...
April 4, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28384425/ionoregulatory-characteristics-of-non-rio-negro-characiforms-and-cichlids
#18
R J Gonzalez, S L Jones, T V Nguyen
We examined ionoregulatory characteristics of two species of characiform fish and two species of cichlids that are not native to the Rio Negro, an extremely ion-poor, acidic tributary of the Amazon River, in order to gain insight into the origin of the specializations possessed by Rio Negro fish. The two characiform species examined, Congo tetras (Phenacogrammus interruptus) and black neon tetras (Hyphessobrycon herbertaxelrodi), had high-affinity/high-capacity transporters that produce high rates of uptake in dilute water...
May 2017: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/28379062/inhibition-of-microrna-21-by-an-antagomir-ameliorates-allergic-inflammation-in-a-mouse-model-of-asthma
#19
Hwa Young Lee, Hea Yon Lee, Joon Young Choi, Jung Hur, In Kyoung Kim, Young Kyoon Kim, Ji Young Kang, Sook Young Lee
AIM OF THE STUDY: MicroRNA-21 (miR-21) is up-regulated during allergic airway inflammation, reflecting a Th2 immune response. We investigated the effects of an miR-21 antagomir and its mechanism of action in a mouse model of acute bronchial asthma. MATERIALS AND METHODS: BALB/c mice were sensitized and challenged with ovalbumin (OVA). The anti-miR-21 antagomir was administered by intranasal inhalation from the day of sensitization. Changes in cell counts, Th2 cytokine levels in bronchoalveolar (BAL) fluid, and airway hyper-responsiveness (AHR) were examined...
April 2017: Experimental Lung Research
https://www.readbyqxmd.com/read/28371345/the-prostate-metastasis-suppressor-gene-ndrg1-differentially-regulates-cell-motility-and-invasion
#20
Anup Sharma, Janet Mendonca, James Ying, Hea-Soo Kim, James E Verdone, Jelani C Zarif, Michael Carducci, Hans Hammers, Kenneth J Pienta, Sushant Kachhap
Experimental and clinical evidence suggests that N-myc downregulated gene 1 (NDRG1) functions as a suppressor of prostate cancer metastasis. Elucidating pathways that drive survival and invasiveness of NDRG1-deficient prostate cancer cells can help in designing therapeutics to target metastatic prostate cancer cells. However, the molecular mechanisms that lead NDRG1-deficient prostate cancer cells to increased invasiveness remain largely unknown. In this study, we demonstrate that NDRG1-deficient prostate tumors have decreased integrin expression and reduced cell adhesion and motility...
April 2, 2017: Molecular Oncology
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