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Kyung-Ah Cho, Minhwa Park, Yu-Hee Kim, Hea-Young Park Choo, Kyung Ho Lee
Mast cells are central regulators of allergic inflammation that function by releasing various proallergic inflammatory mediators, including histamine, eicosanoids and proinflammatory cytokines. Occasionally, bacterial infections may initiate or worsen allergic inflammation. A number of studies have indicated that activation of lipoxygenase in mast cells positive regulates allergic inflammatory responses by generating leukotrienes and proinflammatory cytokines. In the present study, the effects of benzoxazole derivatives on the lipopolysaccharide (LPS)‑induced expression of proinflammatory cytokines, production of histamine and surface expression of co‑stimulatory molecules on bone marrow-derived mast cells (BMMCs) were studied...
March 9, 2018: Molecular Medicine Reports
Gyu Hyeong Lee, Ja Hea Gu
No abstract text is available yet for this article.
March 5, 2018: Archives of Plastic Surgery
Hea Nam Hong, Ju Hee Shim, You Jin Won, Jong Yoon Yoo, Chang Ho Hwang
BACKGROUND: The objective of this study was to investigate the underlying molecular mechanisms and the therapeutic time window for preventing astrogliosis with erythropoietin (EPO) treatment after in vitro modeled spinal cord injury (SCI). METHODS: Cultured rat spinal cord astrocytes were treated with kainate and scratching to generate an in vitro model of SCI. EPO (100U/mL or 300U/mL) was added immediately or 2, 4, or 8 hours after injury. Some cultures were also treated with AG490, an inhibitor of the EPO-EPO receptor (EpoR) pathway mediator Janus kinase 2 (JAK2)...
March 2018: Medicine (Baltimore)
Lihui Tian, Ming Fu, Wei Xiong
High-entropy alloys (HEAs) are promising structural materials due to their excellent comprehensive performances. The use of mechanically alloyed powders to deposit HEA coatings through atmospheric plasma spraying (APS) is an effective approach that can broaden the application areas of the HEAs. In this paper, a ductility-brittleness AlCoCrFeNiSi system was chosen as an object of study, and the detailed evolution of the surface morphology, particle size distribution, and microstructure of the powder during mechanical alloying was investigated...
February 23, 2018: Materials
M Vandekerckhove, W Van Hecke, M Quirin, J De Mey
Current research on emotion shows an increasing interest in the neuronal correlates of emotion regulation (ER). While previous research on ER has focused on gray matter correlates, this study represents the first exploratory study on white matter integrity and brain networks of ER. Responding to the gap between cognitive and affective approaches of ER, pertaining to some of the daily emotional stressors, the present study investigates a complementary experiential approach such as 'Emotional approach' or the tendency to affectively acknowledge, understand and express emotional experience (cf...
February 15, 2018: Behavioural Brain Research
Gyoung Hwa Jeong, Il-Bok Lee, Donghyun Lee, Hea-Min Lee, Seungmin Baek, O-Phil Kwon, Prashant N Kumta, Songhun Yoon, Sang-Wook Kim
Fabrication of β-CoV3O8 nanorods embedded in graphene sheets and its application as electrochemical charge storage electrodes is reported. From surfactant treatment of raw graphite, graphene was directly prepared and its nanocomposite with β-CoV3O8 nanorods distributed between graphene layers (β-CoV3O8-G) was synthesized by hydrothermal method. When applied as anode in lithium-ion batteries, the β-CoV3O8-G anode exhibits greatly improved charge and discharge capacities of 790 and 627 mAh∙g-1, respectively, with unexpectedly high initial efficiency of 82%...
February 9, 2018: Nanotechnology
Koeun Han, Hea-Young Lee, Na-Young Ro, On-Sook Hur, Joung-Ho Lee, Jin-Kyung Kwon, Byoung-Cheorl Kang
Capsaicinoids are unique compounds produced only in peppers (Capsicum spp.). Several studies using classical quantitative trait loci (QTLs) mapping and genomewide association studies (GWAS) have identified QTLs controlling capsaicinoid content in peppers; however, neither the QTLs common to each population nor the candidate genes underlying them have been identified due to the limitations of each approach used. Here, we performed QTL mapping and GWAS for capsaicinoid content in peppers using two recombinant inbred line (RIL) populations and one GWAS population...
February 6, 2018: Plant Biotechnology Journal
Seongyeon Cho, Sang Min Lee, Ho Yun Shin, Min Su Kim, Yiel Hea Seo, Yong Kyun Cho, Jinwoo Lee, Sang Pyo Lee, Moon Il Kim
Nanomaterials that exhibit enzyme-like characteristics, which are called nanozymes, have recently attracted significant attention due to their potential to overcome the intrinsic limitations of natural enzymes, such as low stability and relatively high cost for preparation and purification. In this study, we report a highly efficient colorimetric allergy detection system based on an immunoassay utilizing the peroxidase-mimicking activity of hierarchically structured platinum nanoparticles (H-Pt NPs). The H-Pt NPs had a diameter of 30 nm, and were synthesized by a seed-mediated growth method, which led to a significant amount of peroxidase-like activity...
February 6, 2018: Analyst
Young-Do Kwon, Hea-Jong Chung, Sun Joo Lee, Sun-Hwa Lee, Byung-Hoon Jeong, Hee-Kwon Kim
Prostate-specific membrane antigen (PSMA) is an important biological target for therapy and diagnosis of prostate cancer. In this study, novel multivalent PSMA inhibitors with glutamate-urea-lysine structures were designed to improve inhibition characteristics. Precursors of the novel inhibitors were prepared from glutamic acid with di-tert-butyl ester. A near-infrared molecular dye, sulfo-Cy5.5, was introduced into the precursors to generate the final PSMA fluorescent inhibitors, compounds 12-14, to visualize prostate cancer...
January 31, 2018: Bioorganic & Medicinal Chemistry Letters
Hea Ree Park, Min Jae Seong, Young-Min Shon, Eun Yeon Joo, Dae-Won Seo, Seung Bong Hong
Ictal automatism with preserved responsiveness (APR) has been reported, particularly in nondominant temporal lobe epilepsy (TLE), but its pathophysiology remains poorly understood. This study sought to investigate the relationship between APRs and increased cerebral blood flow (CBF) using ictal single photon emission computed tomography (SPECT) in TLE. Forty-seven subjects with right mesial TLE (15 with and 32 without APR) were enrolled. Patients with APR (APR+) were subdivided into four groups according to degree of responsiveness during seizures...
January 19, 2018: Epilepsy & Behavior: E&B
Hea-Won Kim, Taekyung Park, Stephanie Quiring, Diana Barrett
PURPOSE: A coalition model is often used to serve victims of human trafficking but little is known about whether the model is adequately meeting the needs of the victims. The purpose of this study was to examine anti-human trafficking collaboration model in terms of its impact and the collaborative experience, including challenges and lessons learned from the service providers' perspective. METHOD: Mixed methods study was conducted to evaluate the impact of a citywide anti-trafficking coalition model from the providers' perspectives...
February 2, 2018: Journal of Evidence-informed Social Work
Bon-Hyeock Koo, Bong-Gu Yi, Myeong-Seon Jeong, Seung-Hea Kwon, Kwang-Lae Hoe, Young-Guen Kwon, Moo-Ho Won, Young-Myeong Kim, Sungwoo Ryoo
Arginase inhibition exhibits beneficial effects in vascular endothelial and smooth muscle cells. In human aortic smooth muscle cells (hAoSMCs), native low-density lipoprotein (nLDL) induced the production of interleukin-8 (IL-8) that is involved in the pathogenesis of cardiovascular diseases. Therefore, we examined the effect of arginase inhibition on IL-8 production and the underlying mechanism. In hAoSMCs, reverse transcription-PCR, western blotting and immunocytochemistry with MitoTracker confirmed that arginase II was confined predominantly to mitochondria...
February 2, 2018: Experimental & Molecular Medicine
Dennis Karlsson, Gustav Ek, Johan Cedervall, Claudia Zlotea, Kasper Trans Møller, Thomas Christian Hansen, Jozef Bednarčík, Mark Paskevicius, Magnus Helgerud Sørby, Torben René Jensen, Ulf Jansson, Martin Sahlberg
A high-entropy alloy (HEA) of HfNbTiVZr was synthesized using an arc furnace followed by ball milling. The hydrogen absorption mechanism was studied by in situ X-ray diffraction at different temperatures and by in situ and ex situ neutron diffraction experiments. The body centered cubic (BCC) metal phase undergoes a phase transformation to a body centered tetragonal (BCT) hydride phase with hydrogen occupying both tetrahedral and octahedral interstitial sites in the structure. Hydrogen cycling of the alloy at 500 °C is stable...
February 1, 2018: Inorganic Chemistry
Seon Goo Kim, Ji Hea Yooun, Dong Eun Kim, Eung-Seok Lee, Taeg Kyu Kwon, Shin Kim, Jong Wook Park
Resistance to anoikis and growth in anchorage-independent conditions are hallmarks of highly metastatic cancer cells. Anoikis is a type of apoptosis induced by inadequate cell/extracellular matrix (ECM) attachment and an attractive anti-cancer therapeutic strategy in cancer chemotherapeutic field. Therefore, the development of anoikis-inducing agents is useful and promising to overcome cancer. When FPDHP, a novel anoikis-inducing agent, was treated within 3h, FPDHP induced massive cell detachment in various human cancer cells, irrespective of apoptosis...
February 1, 2018: Journal of Cellular Biochemistry
Jing Liu, Enkhchimeg Lkhagva, Hea-Jong Chung, Hyeon-Jin Kim, Seong-Tshool Hong
Ammonia is constantly produced as a metabolic waste from amino acid catabolism in mammals. Ammonia, the toxic waste metabolite, is resolved in the liver where the urea cycle converts free ammonia to urea. Liver malfunctions cause hyperammonemia that leads to central nervous system (CNS) dysfunctions, such as brain edema, convulsions, and coma. The current treatments for hyperammonemia, such as antibiotics or lactulose, are designed to decrease the intestinal production of ammonia and/or its absorption into the body and are not effective, besides being often accompanied by side effects...
January 28, 2018: Nutrients
Me-Hea Park, Peerapong Sangwanangkul, Dong-Ryeol Baek
Black tomatoes have a unique color and higher lycopene content than typical red tomatoes. Here, black tomatoes were investigated how maturation stage and storage temperature affected carotenoid and chlorophyll accumulation. Immature fruits were firmer than mature fruits, but failed to develop their distinctive color and contained less lycopene when stored at 8 °C. Hunter a* values of black tomatoes increased with storage temperature and duration; storage of immature fruits at high temperature favored lycopene accumulation...
January 2018: Saudi Journal of Biological Sciences
Trina Horn, Janis Hamilton, Joanne Kosanke, Virginia W Hare, Wendy Kluver, Wendy Beres, Sandra Nance, Margaret A Keller
For patients requiring multiple transfusions and patients with positive direct antiglobulin tests (DATs), an extended red blood cell (RBC) phenotype can provide valuable information and help to determine the risk of forming alloantibodies. In some instances, the phenotype may be used for prophylactic matching. Phenotyping in this patient population is often hindered by the presence of circulating donor cells and/or by a positive DAT. Several methods, such as EDTA glycine acid (EGA) treatment to remove IgG, hypotonic saline wash to separate autologous RBCs, or reticulocyte separation, are often used in these situations to isolate patient RBCs for serologic phenotyping...
December 2017: Immunohematology
Lianne Merchuk-Ovnat, Roi Silberman, Efrat Laiba, Andreas Maurer, Klaus Pillen, Adi Faigenboim, Eyal Fridman
Increasing crop productivity under climate change requires the identification, selection and utilization of novel alleles for breeding. We analyzed the genotype and field phenotype of the barley HEB-25 multi-parent mapping population under well-watered and water-limited (WW and WL) environments for two years. A genome-wide association study (GWAS) for genotype by-environment interactions was performed for ten traits including flowering time (HEA) and plant grain yield (PGY). Comparison of the GWAS for traits per-se to that for QTL-by-environment interactions (QxE), indicates the prevalence of QxE mostly for reproductive traits...
January 20, 2018: Journal of Experimental Botany
Eyal Eshed, Natalya Larianovsky, Alexey Kovalevsky, Vladimir Popov, Igor Gorbachev, Vladimir Popov, Alexander Katz-Demyanetz
Refractory-based high entropy alloys (HEAs) of the 2nd-generation type are new intensively-studied materials with a high potential for structural high-temperature applications. This paper presents investigation results on microstructural evolution and phase formation in as-cast and subsequently heat-treated HEAs at various temperature-time regimes. Microstructural examination was performed by means of scanning electron microscopy (SEM) combined with the energy dispersive spectroscopy (EDS) mode of electron probe microanalysis (EPMA) and qualitative X-ray diffraction (XRD)...
January 23, 2018: Materials
Seo-Hui Gwon, Hyun Kyu Kim, Hea Ja Baek, Young-Don Lee, Joon Yeong Kwon
Survival of embryos largely depends on yolk processing during early development. Proteolytic enzymes, cathepsin B & D (ctsb & ctsd) are known to have some important roles in yolk processing of various fish species. Mature female red spotted groupers were injected with human chorionic gonadotropin (HCG) to induce ovulation. The fertilized eggs and embryos were sampled at 0, 4 and 24 HPF (hours post fertilization). Survivals of each groups of embryos were checked at 24 and 48 HPH (hours post hatching). Transcripts of ctsb & ctsd showed the highest level at 0 HPF and relatively high at 4 HPF, but greatly decreased at 24 HPF...
December 2017: Balsaeng'gwa Saengsig
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