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https://www.readbyqxmd.com/read/28747551/egfr-or-her2-inhibition-modulates-the-tumor-microenvironment-by-suppression-of-pd-l1-and-cytokines-release
#1
Koung Jin Suh, Ji Hea Sung, Jin Won Kim, Song-Hee Han, Hye Seung Lee, Ahrum Min, Mi Hyun Kang, Ji Eun Kim, Ji-Won Kim, Se Hyun Kim, Jeong-Ok Lee, Yu Jung Kim, Keun-Wook Lee, Jee Hyun Kim, Soo-Mee Bang, Seock-Ah Im, Jong Seok Lee
BACKGROUND: Characteristics of tumor microenvironment have been suggested as predictive markers of anti-EGFR or anti-HER2 treatment response. However, the effect of EGFR/HER2 signal blockade on the tumor immune microenvironment is unclear. METHODS: EGFR/HER2 pathway signaling and PD-L1 expression in gastric cancer cell lines were screened by western blot analysis. PD-L1 and HER2 expressions in 251 resected gastric tumors were determined by immunohistochemistry, and changes in EFGR, HER2, and PD-L1 expression in paired specimens between pre- and post-chemotherapy were evaluated...
July 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/28746905/a-pm7-dynamic-residue-ligand-interactions-energy-landscape-of-the-bace1-inhibitory-pathway-by-hydroxyethylamine-compounds-part-i-the-flap-closure-process
#2
Carlos Gueto-Tettay, Alejandro Martinez-Consuegra, Joshua Zuchniarz, Luis Roberto Gueto-Tettay, Juan Carlos Drosos-Ramírez
BACE1 is an enzyme of scientific interest because it participates in the progression of Alzheimer's disease. Hydroxyethylamines (HEAs) are a family of compounds which exhibit inhibitory activity toward BACE1 at a nanomolar level, favorable pharmacokinetic properties and oral bioavailability. The first step in the inhibition of BACE1 by HEAs consists of their entrance into the protease active site and the resultant conformational change in the protein, from Apo to closed form. These two conformations differ in the position of an antiparallel loop (called the flap) which covers the entrance to the catalytic site...
July 14, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28733112/distinctions-in-gene-specific-changes-in-dna-methylation-in-response-to-folic-acid-supplementation-between-women-with-normal-weight-and-obesity
#3
Hea Jin Park, Lynn B Bailey, Deanna C Shade, Dorothy B Hausman, Natalie M Hohos, Richard B Meagher, Gail Pa Kauwell, Richard D Lewis, Alicia K Smith
BACKGROUND/OBJECTIVES: Obesity and maternal folate deficiency are associated with increased risk for neural tube defects (NTDs). Limited knowledge exists on the impact of folate status or obesity on DNA methylation of genes related to NTD risk and folate metabolism. SUBJECTS/METHODS: Women (18-35y) with normal weight (NW; BMI 18.5-24.9kg/m(2); n=12) and obesity (OB; BMI >30kg/m(2); n=6) were provided FA (800μg/d) for 8-weeks. Serum folate concentration and changes in DNA methylation across 2098 CpG sites in 91 genes related to NTD risk and folate metabolism were examined...
July 18, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28702703/transfixing-kirshner-wires-for-fixation-of-intertrochanteric-valgus-osteotomies-in-management-of-pediatric-coxa-vara
#4
Ahmed Shawkat Rizk
BACKGROUND: Coxa vara is a radiological term describing a decrease in the neck-shaft angle to 120° or less. Coxa vara is associated with pathomechanical changes that can manifest clinically. If left untreated, coxa vara can affect the normal development of the pediatric hip. Valgus osteotomy is the standard surgical treatment for coxa vara, but there is no consensus regarding the optimal osteotomy technique and fixation method. The work reported here aimed to highlight transfixing wires as a fixation method for valgus osteotomy applied as treatment for various types of pediatric coxa vara...
July 12, 2017: Journal of Orthopaedics and Traumatology: Official Journal of the Italian Society of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/28700637/contingent-association-between-the-size-of-the-social-support-network-and-osteoporosis-among-korean-elderly-women
#5
Seungwon Lee, Da Hea Seo, Kyoung Min Kim, Eun Young Lee, Hyeon Chang Kim, Chang Oh Kim, Yoosik Youm, Yumie Rhee
OBJECTIVE: To investigate the association between the number of personal ties (or the size of the social support network) and the incidence of osteoporosis among older women in Korea. METHODS: Data from the Korean Urban Rural Elderly Study were used. Bone density was measured by dual-energy X-ray absorptiometry at the lumbar spine (L1-L4) and femur neck. T-score, the standardized bone density compared with what is normally expected in a healthy young adult, was measured and the presence of osteoporosis was determined, if the T-score was < -2...
2017: PloS One
https://www.readbyqxmd.com/read/28677354/prevalence-of-immediate-type-food-allergy-in-korean-schoolchildren-in-2015-a-nationwide-population-based-study
#6
Minji Kim, Ji Young Lee, Hyun Young Jeon, Hea Kyoung Yang, Kee Jae Lee, Youngshin Han, Yang Hee Kim, Jihyun Kim, Kangmo Ahn
PURPOSE: This study aimed to determine the prevalence of immediate-type food allergy (FA) among schoolchildren in Korea. METHODS: A nationwide, cross-sectional study was performed in September 2015. A stratified random sample of 50,000 participants was selected from children and adolescents aged 6-7 years (n=17,500), 9-10 years (n=17,500), 12-13 years (n=7,500), and 15-16 years (n=7,500). Parents were asked to complete a questionnaire on the detailed history of immediate-type FA...
September 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/28675628/a-sensitive-uhplc-ms-ms-method-for-the-simultaneous-quantification-of-three-lignans-in-human-plasma-and-its-application-to-a-pharmacokinetic-study
#7
Sook-Jin Kim, Hwajin Shin, Seong-Moon Cheon, Se-Mi Ko, Seong-Ho Ham, Young-Dal Kwon, Yong-Bok Lee, Hea-Young Cho
The aim of this study was to develop an analytical method to simultaneously analyze schizandrin, schizandrol B, and gomisin N lignans in human plasma using ultra high performance liquid chromatography with tandem mass spectrometry. The three lignans were separated using a mobile phase of water and acetonitrile containing 0.02% acetic acid equipped with a Kinetex C18 column (2.1 mm × 50 mm, 1.7 μm). This analysis was achieved by multiple reaction monitoring mode in an electrospray interface. The mass transitions were m/z 433...
July 4, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28675252/diversity-and-distribution-of-ticks-from-domestic-ruminants-in-lebanon
#8
Mayssaa Fawaz Dabaja, Maria Tempesta, Ali Bayan, Gesualdo Vesco, Gesualdo Vesco, Grazia Greco, Alessandra Torina, Valeria Blanda, Francesco La Russa, Salvatore Scimeca, Mohamad Ezzedine, Hussein Mortada, Didier Raoult, Pierre Edouard Fournier, Mohamad Mortada
Ticks (Acari: Ixodidae) are ectoparasites infesting livestock in every geographic area in the world and they are vectors of several viral, bacterial, and protozoan pathogens to animals and humans worldwide. A deep knowledge of the geographical distribution of these arthropods would have a key role in the control of tick-borne diseases. Few data are available about tick presence in domestic ruminants in Lebanon. The study aimed at providing an analysis of tick presence and distribution in Lebanon. Ticks were collected from cattle, sheep, and goats farms distributed in 6 Lebanese provinces between June and September 2014...
June 30, 2017: Veterinaria Italiana
https://www.readbyqxmd.com/read/28668109/seasonal-variation-and-monthly-patterns-of-skin-symptoms-in-korean-children-with-atopic-eczema-dermatitis-syndrome
#9
Minji Kim, Young-Min Kim, Ji Young Lee, Hea-Kyoung Yang, Hyunmi Kim, Joongbum Cho, Kangmo Ahn, Jihyun Kim
BACKGROUND: There have been controversies about the seasonality in aggravation of atopic eczema/dermatitis syndrome (AEDS) symptoms, although understanding the seasonal patterns of AEDS symptoms is an important step in preventing exacerbation through proactive management. OBJECTIVE: The aim of this study was to evaluate whether there are seasonal variations or monthly patterns of symptoms in children with AEDS. METHODS: A total of 590 children with AEDS (median age, 21 months) were enrolled and were followed up for at least 1 year between August 2012 and March 2015...
July 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28662652/the-korean-study-of-women-s-health-related-issues-k-stori-rationale-and-study-design
#10
Ha Na Cho, Eunji Choi, Da Hea Seo, Mina Suh, Hoo-Yeon Lee, Boyoung Park, Sohee Park, Juhee Cho, Sue Kim, Yeong-Ran Park, Joong-Yeon Lim, Younjihin Ahn, Hyun-Young Park, Kui Son Choi, Yumie Rhee
BACKGROUND: Measures to address gender-specific health issues are essential due to fundamental, biological differences between the sexes. Studies have increasingly stressed the importance of customizing approaches directed at women's health issues according to stages in the female life cycle. In Korea, however, gender-specific studies on issues affecting Korean women in relation to stages in their life cycle are lacking. Accordingly, the Korean Study of Women's Health-Related Issues (K-Stori) was designed to investigate life cycle-specific health issues among women, covering health status, awareness, and risk perceptions...
June 29, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28662413/effects-of-annealing-on-the-microstructural-evolution-and-phase-transition-in-an-alcrcufeni2-high-entropy-alloy
#11
Lin Guo, Wenqian Wu, Song Ni, Zhangwei Wang, Min Song
An AlCrCuFeNi2 high entropy alloy (HEA) was prepared by arc melting, followed by annealing at different temperatures. The elemental distributions, phase formation, morphology and microstructural evolution of the HEA in both the as-cast state and annealed state were investigated. The results indicate that the HEA undergoes elements segregation, precipitation and spinodal decomposition. The as-cast alloy consists of Cr-Fe-Ni rich FCC dendritic (DR) phase and BCC interdendritic (ID) phase. Spherical Fe-Cr rich BCC precipitates were found to disperse in Al-Ni rich B2 (ordered BCC) matrix...
June 21, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/28651157/different-patterns-in-the-risk-of-newly-developed-fatty-liver-and-lipid-changes-with-tamoxifen-versus-aromatase-inhibitors-in-postmenopausal-women-with-early-breast-cancer-a-propensity-score-matched-cohort-study
#12
Namki Hong, Han Gyul Yoon, Da Hea Seo, Seho Park, Seung Il Kim, Joo Hyuk Sohn, Yumie Rhee
BACKGROUND: Management of metabolic complications of long-term adjuvant endocrine therapy in early breast cancer remained an unmet need. We aimed to compare the effects of tamoxifen (TMX) and aromatase inhibitors (AIs) on the risk of fatty liver in conjunction with longitudinal changes in the serum lipid parameters. METHODS: Among 1203 subjects who were taking adjuvant TMX or AI (anastrozole or letrozole) without fatty liver at baseline, those taking TMX or AI were 1:1 matched on the propensity score...
June 23, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28623473/increasing-the-bile-acid-sequestration-performance-of-cationic-hydrogels-by-using-an-advanced-controlled-polymerization-technique
#13
Patrícia V Mendonça, André Matos, Andreia F Sousa, Arménio C Serra, Sérgio Simões, Jorge F J Coelho
PURPOSE: To investigate the influence of the polymerization technique and the content of hydroxyl groups on the performance of new bile acid sequestrants based on PAMPMTA-co-PHEA (PAMPTMA: poly((3-acrylamidopropyl)trimethylammonium chloride); PHEA: poly(2-hydroxyethyl acrylate)) hydrogels. METHODS: PAMPMTA-co-PHEA hydrogels were prepared using either free radical polymerization or supplemental activator and reducing agent atom transfer radical polymerization. The chemical structure and composition of the hydrogels was confirmed by both FTIR and ssNMR...
June 16, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28614303/bacterial-pathogens-a-spoonful-of-sugar-could-be-the-medicine
#14
Hea-Jin Jung, Eric G Pamer
No abstract text is available yet for this article.
June 22, 2017: Nature
https://www.readbyqxmd.com/read/28590527/phase-transformation-ductilization-of-brittle-high-entropy-alloys-via-metastability-engineering
#15
Hailong Huang, Yuan Wu, Junyang He, Hui Wang, Xiongjun Liu, Ke An, Wei Wu, Zhaoping Lu
High-entropy alloys (HEAs) in which interesting physical, chemical, and structural properties are being continuously revealed have recently attracted extensive attention. Body-centered cubic (bcc) HEAs, particularly those based on refractory elements are promising for high-temperature application but generally fail by early cracking with limited plasticity at room temperature, which limits their malleability and widespread uses. Here, the "metastability-engineering" strategy is exploited in brittle bcc HEAs via tailoring the stability of the constituent phases, and transformation-induced ductility and work-hardening capability are successfully achieved...
June 7, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28578428/surface-modification-of-polyvinylidene-fluoride-pvdf-membrane-via-radiation-grafting-novel-mechanisms-underlying-the-interesting-enhanced-membrane-performance
#16
Liguo Shen, Shushu Feng, Jianxi Li, Jianrong Chen, Fengquan Li, Hongjun Lin, Genying Yu
This study provided the first attempt of grafting hydrophobic polyvinylidene fluoride (PVDF) membrane with hydrophilic hydroxyethyl acrylate (HEA) monomer via a radiation grafting method. This grafted membrane showed an enhanced hydrophilicity (10° decrease of water contact angle), water content ratio, settling ability and wettability compared to the control membrane. Interestingly, filtration tests showed an improved dependence of water flux of the grafted membrane on the solution pH in the acidic stage. Atomic force microscopy (AFM) analysis provided in-situ evidence that the reduced surface pore size of the grafted membrane with the solution pH governed such a dependence...
June 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28528531/diversity-and-distribution-of-ticks-from-domestic-ruminants-in-lebanon
#17
Mayssaa Fawaz Dabaja, Maria Tempesta, Ali Bayan, Gesualdo Vesco, Grazia Greco, Grazia Greco, Alessandra Torina, Valeria Blanda, Francesco La Russa, Salvatore Scimeca, Rossella Lelli, Mohamad Ezzedine, Hussein Mortada, Didier Raoult, Pierre Edouard Fournier, Mohamad Mortada
Ticks (Acari: Ixodidae) are ectoparasites infesting livestock in every geographic area in the world and they are vectors of several viral, bacterial, and protozoan pathogens to animals and humans worldwide. A deep knowledge of the geographical distribution of these arthropods would have a key role in the control of tick-borne diseases. Few data are available about tick presence in domestic ruminants in Lebanon. The study aimed at providing an analysis of tick presence and distribution in Lebanon. Ticks were collected from cattle, sheep, and goats farms distributed in 6 Lebanese provinces between June and September 2014...
April 11, 2017: Veterinaria Italiana
https://www.readbyqxmd.com/read/28516149/dataset-for-acrylate-silica-nanoparticles-formulations-and-photocured-composites-viscosity-filler-dispersion-and-bulk-poisson-s-ratio
#18
Hubert Gojzewski, Mariola Sadej, Ewa Andrzejewska, Martyna Kokowska
UV-curable polymer composites are of importance in industry, biomedical applications, scientific fields, and daily life. Outstanding physical properties of polymer composites were achieved with nanoparticles as filler, primarily in enhancing mechanical strength or barrier properties. Structure-property relationships of the resulting nanocomposites are dictated by the polymer-filler molecular architecture, i.e. interactions between polymer matrix and filler, and high surface area to volume ratio of the filler particles...
June 2017: Data in Brief
https://www.readbyqxmd.com/read/28515081/flexible-ammonia-handling-strategies-using-both-cutaneous-and-branchial-epithelia-in-the-highly-ammonia-tolerant-pacific-hagfish
#19
Alexander M Clifford, Alyssa M Weinrauch, Susan L Edwards, Michael P Wilkie, Greg G Goss
Hagfish consume carrion, potentially exposing them to hypoxia, hypercarbia, and high environmental ammonia (HEA). We investigated branchial and cutaneous ammonia handling strategies by which Pacific hagfish (Eptatretus stoutii) tolerate and recover from high ammonia loading. Hagfish were exposed to HEA (20 mmol L(-1)) for 48 h to elevate plasma total ammonia (TAmm) levels before placement into divided chambers for a 4 h recovery period in ammonia-free seawater where ammonia excretion (JAmm) was measured independently in the anterior and posterior compartments...
May 17, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28503455/lesion-characteristics-of-chronic-dysphagia-in-patients-with-supratentorial-stroke
#20
Sol Jang, Hea Eun Yang, Hee Seung Yang, Dae Hyun Kim
OBJECTIVE: To analyze the relationship between brain lesion location and type of chronic dysphagia in patients with supratentorial stroke. METHODS: Data from 82 chronic stroke patients who underwent videofluoroscopic swallowing studies at >6 months after an initial stroke event were retrospectively analyzed. Delayed oral transit time, delayed pharyngeal transit time, and the presence of aspiration were extracted. A voxel-based lesion symptom mapping (VLSM) analysis was used to correlate types of dysphagia with specific brain lesions...
April 2017: Annals of Rehabilitation Medicine
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