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https://www.readbyqxmd.com/read/28079175/interstitial-atoms-enable-joint-twinning-and-transformation-induced-plasticity-in-strong-and-ductile-high-entropy-alloys
#1
Zhiming Li, Cemal Cem Tasan, Hauke Springer, Baptiste Gault, Dierk Raabe
High-entropy alloys (HEAs) consisting of multiple principle elements provide an avenue for realizing exceptional mechanical, physical and chemical properties. We report a novel strategy for designing a new class of HEAs incorporating the additional interstitial element carbon. This results in joint activation of twinning- and transformation-induced plasticity (TWIP and TRIP) by tuning the matrix phase's instability in a metastable TRIP-assisted dual-phase HEA. Besides TWIP and TRIP, such alloys benefit from massive substitutional and interstitial solid solution strengthening as well as from the composite effect associated with its dual-phase structure...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28077828/-hospital-arrival-rate-within-golden-time-and-factors-influencing-prehospital-delays-among-patients-with-acute-myocardial-infarction
#2
Hye Mi Ahn, Hyeongsu Kim, Kun Sei Lee, Jung Hyun Lee, Hyo Seon Jeong, Soung Hoon Chang, Kyeong Ryong Lee, Sung Hea Kim, Eun Young Shin
PURPOSE: This research was done to identify the hospital arrival rate and factors related to prehospital delay in arriving at an emergency medical center within the golden time after symptom onset in patients with acute myocardial infarction (AMI). METHODS: Data used in the research was from the National Emergency Department Information System of the National Emergency Medical Center which reported that in 2014, 9,611 patients went to emergency medical centers for acute myocardial infarction...
December 2016: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28064067/simultaneous-determination-of-imperatorin-and-its-metabolite-xanthotoxol-in-rat-plasma-and-urine-by-lc-ms-ms-and-its-application-to-pharmacokinetic-studies
#3
Lien Ngo, Phuong Tran, Seong-Ho Ham, Jung-Hee Cho, Hea-Young Cho, Yong-Bok Lee
An accurate, precise, selective, and sensitive liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination of imperatorin (IMP) and its metabolite, xanthotoxol (XAN), in rat plasma and urine samples. The analytes, along with psoralen as an internal standard, were determined by multiple reaction monitoring (MRM) operated in the positive electrospray ionization (ESI) mode. Chromatographic separation was performed on an Acquity UPLC BEH C18 column (50mm×2...
December 28, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28063438/ground-state-properties-of-weakly-bound-helium-alkali-trimers
#4
P Stipanović, L Vranješ Markić, D Zarić, J Boronat
Weakly bound triatomic molecules consisting of two helium atoms and one alkali metal atom are studied by means of the diffusion Monte Carlo method. We determined the stability of (4)He2A, (4)He(3)HeA, and (3)He2A, where A is one of the alkali atoms Li, Na, K, Rb, or Cs. Some of the trimers with (3)He are predicted to be self-bound for the first time, but this is observed to be dependent on the He-A interaction potential model. In addition to the ground-state energy of the trimers, we determined their density, radial, and angular distributions...
January 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28061469/diagnosis-of-cytomegalovirus-pneumonia-by-quantitative-polymerase-chain-reaction-using-bronchial-washing-fluid-from-patients-with-hematologic-malignancies
#5
Hwa Young Lee, Chin Kook Rhee, Joon Young Choi, Hea Yon Lee, Jong Wook Lee, Dong Gun Lee
BACKGROUND: The incidence of cytomegalovirus (CMV) pneumonia is increasing in patients diagnosed with hematologic malignancies. The utility of CMV-DNA viral load measurement has not been standardized, and viral cut-off values have not been established. This study was designed to investigate the utility of CMV quantitative real-time PCR (qRT-PCR) using bronchial washing fluid. METHODS: We retrospectively reviewed the microbiologic and pathologic results of bronchial washing fluid and biopsy specimens in addition to the patients' clinical characteristics...
January 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28059106/the-effect-of-electronic-structure-on-the-phases-present-in-high-entropy-alloys
#6
Zhaoyuan Leong, Jan S Wróbel, Sergei L Dudarev, Russell Goodall, Iain Todd, Duc Nguyen-Manh
Multicomponent systems, termed High Entropy Alloys (HEAs), with predominantly single solid solution phases are a current area of focus in alloy development. Although different empirical rules have been introduced to understand phase formation and determine what the dominant phases may be in these systems, experimental investigation has revealed that in many cases their structure is not a single solid solution phase, and that the rules may not accurately distinguish the stability of the phase boundaries. Here, a combined modelling and experimental approach that looks into the electronic structure is proposed to improve accuracy of the predictions of the majority phase...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28052796/genetic-variants-of-the-gasdermin-b-gene-associated-with-the-development-of-aspirin-exacerbated-respiratory-diseases
#7
Lyoung Hyo Kim, HunSoo Chang, Suhg Namgoong, Ji On Kim, Hyun Sub Cheong, Seo-Gyeong Lee, Jong Sook Park, Ae Rin Baek, So-My Koo, Inseon S Choi, Mi-Kyeong Kim, Hea-Sim Park, Choon-Sik Park, Hyoung Doo Shin
BACKGROUND: Aspirin-exacerbated respiratory disease (AERD) is characterized by a severe and sudden asthma attack after aspirin ingestion in patients with asthma. We studied associations with six common single nucleotide polymorphisms (SNP) of the gasdermin B gene (GSDMB). OBJECTIVE: DNA obtained from 572 patients with asthma (with AERD, n = 165; and with aspirin-tolerant asthma, n = 407) and 391 normal controls was subjected to genotyping of six SNPs of GSDMB. METHODS: An association analysis between GSDMB variants and AERD, with a fall rate of the forced expiratory volume in the first second of expiration (FEV1), was performed by using logistic and regression models...
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28051186/parametric-study-of-amorphous-high-entropy-alloys-formation-from-two-new-perspectives-atomic-radius-modification-and-crystalline-structure-of-alloying-elements
#8
Q Hu, S Guo, J M Wang, Y H Yan, S S Chen, D P Lu, K M Liu, J Z Zou, X R Zeng
Chemical and topological parameters have been widely used for predicting the phase selection in high-entropy alloys (HEAs). Nevertheless, previous studies could be faulted due to the small number of available data points, the negligence of kinetic effects, and the insensitivity to small compositional changes. Here in this work, 92 TiZrHfM, TiZrHfMM, TiZrHfMMM (M = Fe, Cr, V, Nb, Al, Ag, Cu, Ni) HEAs were prepared by melt spinning, to build a reliable and sufficiently large material database to inspect the robustness of previously established parameters...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28024908/hyp-17-a-novel-voltage-gated-sodium-channel-blocker-relieves-inflammatory-and-neuropathic-pain-in-rats
#9
Jee Youn Lee, Yoo Lim Kam, Jungae Oh, Dong Hyun Kim, Jin-Sung Choi, Hae Young Choi, Sungmin Han, Inchan Youn, Hea-Young Park Choo, Tae Young Yune
Clinical and experimental studies suggest that voltage-gated sodium channels (VGSCs) play a key role in the pathogenesis of neuropathic pain and that blocking agents against these channels can be potentially therapeutic. In the current study, we investigated whether a novel compound, (-)-2-Amino-1-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)-propan-1-one(HYP-17), binds to VGSCs and evaluated its inhibitory effect on Na(+) currents of the rat dorsal root ganglia (DRG) sensory neurons and its analgesic effect on inflammatory and neuropathic pain...
December 24, 2016: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/28017900/the-95-%C3%AE-g-mutation-in-the-5-untranslated-region-of-the-nora-gene-increases-efflux-activity-in-staphylococcus-epidermidis-isolates
#10
Elizabeth García-Gómez, Marcos E Jaso-Vera, Marco A Juárez-Verdayes, María D Alcántar-Curiel, Juan C Zenteno, Gabriel Betanzos-Cabrera, Humberto Peralta, Sandra Rodríguez-Martínez, Mario E Cancino-Díaz, Janet Jan-Roblero, Juan C Cancino-Diaz
In the Staphylococcus aureus ATCC25923 strain, the flqB mutation in the 5'untranslated region (5'UTR) of the norA gene causes increased norA mRNA expression and high efflux activity (HEA). The involvement of the norA gene 5'UTR in HEA has not been explored in S. epidermidis; therefore, we examined the function of this region in S. epidermidis clinical isolates. The selection of isolates with HEA was performed based on ethidium bromide (EtBr) MIC values and efflux efficiency (EF) using the semi-automated fluorometric method...
December 23, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27996975/gene-expression-profiles-and-physiological-data-from-mice-fed-resveratrol-enriched-rice-dj526
#11
Hea-Jong Chung, Heui-Kwan Lee, Hyeon-Jin Kim, So-Hyeon Baek, Seong-Tshool Hong
The molecular mechanism underlying lifespan extension by resveratrol remains widely discussed. To help study this mechanism, we previously created resveratrol-enriched rice, DJ526, by transferring the resveratrol biosynthesis gene into Dongjin rice. DJ526 accumulates 1.4-1.9 μg g(-1) of resveratrol in its grain and can ameliorates age-related deterioration in mice, as compared to control animals, based on assessments of motor coordination, physical strength and cutaneous tissue aging. Here, we present raw data sets, deposited in public repositories, from microarray analysis and physiological data of mice fed with DJ526 and Dongjin rice and treated with resveratrol...
December 20, 2016: Scientific Data
https://www.readbyqxmd.com/read/27996291/is-the-prevalence-of-atopic-dermatitis-in-korean-children-decreasing-analysis-of-the-national-statistics-data-2009-2014
#12
Ji Young Lee, Hea-Kyoung Yang, Minji Kim, Jihyun Kim, Kangmo Ahn
BACKGROUND: The prevalence of atopic dermatitis (AD) in children is increasing in many developing countries. OBJECTIVE: This study aimed to explore trends in the prevalence of AD in Korean children. METHODS: We analyzed data from the Korean National Health Insurance Service from 2009 to 2014. Data for the estimated populations were collected from the Statistics Korea. The annual prevalence of AD was obtained by dividing the number of patients by the estimated population each year...
December 12, 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/27990758/factor-analysis-of-recurrent-biliary-events-in-long-term-follow-up-of-gallstone-pancreatitis
#13
Ji Min Lee, Woo Chul Chung, Hea Jung Sung, Yeon-Ji Kim, Gun Jung Youn, Yun Duk Jung, Sooa Choi, Eun Jung Jeon
OBJECTIVE: Recurrent attacks after acute gallstone pancreatitis (GSP) are a substantial problem with associated morbidity and mortality. The recommended therapies for recurrent attacks are cholecystectomy and endoscopic sphincterotomy (EST). This study aimed to evaluate the long-term results of cholecystectomy and EST after clinical improvement of GSP. METHODS: A consecutive series of patients who were admitted with GSP between January 2003 to December 2014 were analyzed...
December 18, 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27986316/heavy-metals-removal-using-hydrogel-supported-nanosized-hydrous-ferric-oxide-synthesis-characterization-and-mechanism
#14
Yipin Zhang, Zhengkui Li
A new polymer-supported hybrid adsorbent (HFO-P(TAA/HEA)) for highly efficient removal of Pb(2+), Cu(2+), Cd(2+) and Ni(2+) from wastewater was developed by supporting hydrous ferric oxide (HFO) nanoparticles onto a porous poly(trans-Aconitic acid/2-hydroxyethyl acrylate) hydrogel (P(TAA/HEA)) with in situ precipitation method. Swelling kinetics, scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD), thermo-gravimetric analysis (TGA), Fourier transform infrared spectra (FTIR) and X-ray photoelectron spectroscopy (XPS) were used for characterization of the prepared HFO-P(TAA/HEA)...
December 13, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27965271/different-mechanisms-of-na-uptake-and-ammonia-excretion-by-the-gill-and-yolk-sac-epithelium-of-early-life-stage-rainbow-trout
#15
Alex M Zimmer, Jonathan M Wilson, Patricia A Wright, Junya Hiroi, Chris M Wood
In rainbow trout, the dominant site of Na(+) uptake (J(Na)in) and ammonia excretion (Jamm) shifts from the skin to the gills over development. Post-hatch (PH; 7 days post-hatch) larvae utilize the yolk sac skin for physiological exchange, whereas by complete yolk sac absorption (CYA; 30 days post-hatch), the gill is the dominant site. At the gills, J(Na)in and Jamm occur via loose Na(+)/NH4(+) exchange, but this exchange has not been examined in the skin of larval trout. Based on previous work, we hypothesized that, contrary to the gill model, J(Na)in by the yolk sac skin of PH trout occurs independently of Jamm Following a 12-h exposure to high environmental ammonia (HEA; 0...
December 13, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27951623/clinical-significance-of-positive-pneumocystis-jirovecii-polymerase-chain-reaction-in-non-human-immunodeficiency-virus-immunocompromised-patients-in-a-real-practice
#16
Hea Yon Lee, Hye Seon Kang, Hwa Young Lee, Chin Kook Rhee, Sook Young Lee, Seok Chan Kim, Seung Joon Kim, Yeon Joon Park, Young Kyoon Kim, Ji Young Kang
Background/Aims: Pneumocystis jirovecii polymerase chain reaction (PCR) can be helpful in diagnosing Pneumocystis pneumonia (PCP); however it has limitations. We evaluated the prevalence of positive P. jirovecii PCR from non-human immunodeficiency virus (HIV) immunocompromised patients and tried to determine the risk of PCP development. Methods: Between May 2009 and September 2012, P. jirovecii PCR was performed in bronchoscopic specimens from 1,231 adult non-HIV immunocompromised patients suspected of respiratory infection...
December 13, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27941997/primary-cilia-negatively-regulate-melanogenesis-in-melanocytes-and-pigmentation-in-a-human-skin-model
#17
Hyunjung Choi, Ji Hyun Shin, Eun Sung Kim, So Jung Park, Il-Hong Bae, Yoon Kyung Jo, In Young Jeong, Hyoung-June Kim, Youngjin Lee, Hea Chul Park, Hong Bae Jeon, Ki Woo Kim, Tae Ryong Lee, Dong-Hyung Cho
The primary cilium is an organelle protruding from the cell body that senses external stimuli including chemical, mechanical, light, osmotic, fluid flow, and gravitational signals. Skin is always exposed to the external environment and responds to external stimuli. Therefore, it is possible that primary cilia have an important role in skin. Ciliogenesis was reported to be involved in developmental processes in skin, such as keratinocyte differentiation and hair formation. However, the relation between skin pigmentation and primary cilia is largely unknown...
2016: PloS One
https://www.readbyqxmd.com/read/27934498/naphthoquinone-oxindole-alkaloids-coprisidins-a-and-b-from-a-gut-associated-bacterium-in-the-dung-beetle-copris-tripartitus
#18
Soohyun Um, Duc-Hiep Bach, Bora Shin, Chan-Hong Ahn, Seong-Hwan Kim, Hea-Son Bang, Ki-Bong Oh, Sang Kook Lee, Jongheon Shin, Dong-Chan Oh
Coprisidins A and B (1 and 2) were isolated from a gut-associated Streptomyces sp. in the dung beetle Copris tripartitus. Using a combination of spectroscopic techniques, the structures of the compounds were determined to be the first examples of natural naphthoquinone-oxindole alkaloids. Coprisidin A was found to inhibit the action of Na(+)/K(+)-ATPase, and coprisidin B showed activity for the induction of NAD(P)H:quinone oxidoreductase 1.
November 18, 2016: Organic Letters
https://www.readbyqxmd.com/read/27928111/treatment-outcomes-of-patients-treated-for-pulmonary-tuberculosis-after-undergoing-gastrectomy
#19
In Young Jung, Moo Hyun Kim, Woo Yong Jeong, Mi Young Ahn, Yong Duk Jeon, Hea Won Ahn, Jin Young Ahn, Je Eun Song, Dong Hyun Oh, Yong Chan Kim, Eun Jin Kim, Su Jin Jeong, Nam Su Ku, June Myung Kim, Jun Yong Choi
Gastrectomy is a proxy of malnutrition, which may lead to increased risk for developing pulmonary tuberculosis (TB). Malabsorption in gastrectomy patients could lead to low serum levels of rifampicin, which may be related to higher treatment failure. However, there is limited information on treatment outcomes of TB in patients who have undergone gastrectomy. This study aims to determine treatment outcomes and adverse effects in patients treated for TB after undergoing gastrectomy for gastric cancer. During the study period, 112 patients were treated for active TB that developed after gastrectomy for gastric cancer...
2016: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/27918585/the-association-of-family-history-of-premature-cardiovascular-disease-or-diabetes-mellitus-on-the-occurrence-of-gestational-hypertensive-disease-and-diabetes
#20
Dong-Ju Choi, Chang-Hwan Yoon, Heesun Lee, So-Yeon Ahn, Kyung Joon Oh, Hyun-Young Park, Hea Young Lee, Myeong Chan Cho, Ick-Mo Chung, Mi-Seung Shin, Sung-Ji Park, Chi Young Shim, Seong Woo Han, In-Ho Chae
BACKGROUND: Gestational hypertensive diseases (GHD) and gestational diabetes mellitus (GDM) increase the risk of cardiovascular disease (CVD) later in life. However, the association between gestational medical diseases and familial history of CVD has not been investigated to date. In the present study, we examined the association between familial history of CVD and GHD or GDM via reliable questionnaires in a large cohort of registered nurses. METHODS: The Korean Nurses' Survey was conducted through a web-based computer-assisted self-interview, which was developed through consultation with cardiologists, gynecologists, and statisticians...
2016: PloS One
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