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Yasuyuki Shigematsu, Hiroaki Kanda, Toshiya Nagasaki, Takeaki Ishizawa, Yosuke Inoue, Shunji Takahashi
The clinical course of hepatic eosinophilic abscess (HEA) induced by malignant tumors is not well-known; however, it is considered to be a benign hepatic lesion. HEA is difficult to diagnose by imaging alone and a pathological examination is generally needed, particularly in patients with malignant tumors, because the radiological findings can be similar to those of metastasis. We report a case of multiple HEAs with eosinophilia and sigmoid colon cancer that was difficult to diagnose without a pathological examination...
2018: Internal Medicine
Yan Yan Jin, Parul Singh, Hea-Jong Chung, Seong-Tschool Hong
Alzheimer’s disease (AD), characterized by cognitive decline and devastating neurodegeneration, is the most common age-related dementia. Since AD is a typical example of a complex disease that is affected by various genetic and environmental factors, various factors could be involved in preventing and/or treating AD. Extracellular accumulation of beta-amyloid peptide (Aβ) and intracellular accumulation of tau undeniably play essential roles in the etiology of AD. However, interestingly enough, medications targeting Aβ or tau all failed and the only clinically efficient medications for AD are drugs targeting the cholinergic pathway...
May 4, 2018: Nutrients
Bum Sung Kim, Tae-Hoon Kim, Jeong-Hwan Oh, Chang Hee Kwon, Sung Hea Kim, Hyun-Joong Kim, Heung Kon Hwang, Sang-Man Chung
Objective: Cardiovascular complications contribute to postoperative morbidity and mortality in elderly hip fracture patients. Limited data are available regarding which preoperative risk factors predict cardiovascular course following hip fracture surgery (HFS). We used high sensitive troponin I (hs-TnI) assays and clinical parameters to identify preoperative risk factors associated with major adverse cardiac events (MACE) in elderly hip fracture patients. Method: From August 2014 to November 2016, 575 patients with hip fracture were enrolled in a retrospective, single-center registry...
March 2018: Journal of Geriatric Cardiology: JGC
Bum Sung Kim, Jeong Hoon Yang, Woo Jin Jang, Young Bin Song, Joo-Yong Hahn, Jin-Ho Choi, Ki Hong Choi, Sung-Hea Kim, Woo Jung Chun, Hyeon-Cheol Gwon, Seung-Hyuk Choi
Background: Limited data are available on the efficacy of statin therapy in stable ischemic heart disease with chronic total occlusion (CTO) without revascularization. We investigated whether statin therapy could be beneficial in stable patients with CTO without revascularization. Methods: From March 2003 to February 2012, 2,024 patients with at least one CTO were enrolled in a retrospective, single-center registry; 664 of these patients were managed conservatively without an initial revascularization strategy...
April 30, 2018: Journal of Korean Medical Science
Sun Kyung Hwang, Eun Hea Jho
The removals of heavy metals and sulfate in the synthetic acid mine drainages (AMDs) by Desulfovibrio desulfuricans, sulfate-reducing bacteria (SRB), and the indigenous bacteria isolated from the mine area soil sample were studied to compare the AMD treatment efficiencies. The AMD treatment by the D. desulfuricans grown in the Desulfovibrio medium was used to represent bioaugmentation, while the AMD treatment by the indigenous bacteria grown in the Desulfovibrio medium was used to represent biostimulation. The consumption of lactate and sulfate suggested that the zinc (Zn) removal in the Zn-spiked Desulfovibrio medium by D...
April 23, 2018: Science of the Total Environment
Sook-Jin Kim, Se-Mi Ko, Eun-Jeong Choi, Seong-Ho Ham, Young-Dal Kwon, Yong-Bok Lee, Hea-Young Cho
Coumarins in Cham-dang-gwi, the dried root of Angelica gigas Nakai (AGN), possess pharmacological effects on anemia, pain, infection, and articular rheumatism. The AGN root containes decursin (D), decursinol angelate (DA), nodakenin, and decursinol (DOH), a major metabolite of D and DA. The aim of this study was to develop a simultaneous determination method for these four coumarins in human plasma using ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Chromatographic separation was performed on dual columns (Kinetex® C18 column and Capcell core C18 column) with mobile phase consisting of water and acetonitrile at a flow rate of 0...
April 26, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Andrea C Durant, Andrew Donini
The larvae of the mosquito Aedes aegypti inhabit ammonia rich septic tanks in tropical regions of the world that make extensive use of these systems, explaining the prevalence of disease during dry seasons. Since ammonia (NH3 /[Formula: see text]) is toxic to animals, an understanding of the physiological mechanisms of ammonia excretion permitting the survival of A. aegypti larvae in high ammonia environments is important. We have characterized a novel ammonia transporter, AeAmt2 , belonging to the Amt/MEP/Rh family of ammonia transporters...
2018: Frontiers in Physiology
Parul Singh, Hea-Jong Chung, In-Ah Lee, Roshan D'Souza, Hyeon-Jin Kim, Seong-Tshool Hong
BACKGROUND: Recent experimental evidence showed that lactobacilli could be used as potential therapeutic agents for hyperammonemia. However, lack of understanding on how lactobacilli reduce blood ammonia levels limits application of lactobacilli to treat hyperammonemia. RESULTS: We report the finished and annotated genome sequence of L. amylovorus JBD401 (GenBank accession no. CP012389). L. amylovorus JBD401 reducing blood ammonia levels dramatically was identified by high-throughput screening of several thousand probiotic strains both within and across Lactobacillus species in vitro...
April 25, 2018: BMC Genomics
Yan Long, Kai Su, Jinfu Zhang, Xiaobiao Liang, Haiyan Peng, Xiaozhen Li
A NbMoTaWVTi refractory high entropy alloy (HEA) has been successfully synthesized by mechanical alloying (MA) and spark plasma sintering (SPS). The microstructure and mechanical properties of this alloy are investigated. It is observed that only two types of body-centered cubic (BCC) solid solutions are formed in the powders after ball milling for 40 h. However, a new face-centered cubic (FCC) precipitated phase is observed in the BCC matrix of bulk material consolidated by SPS. The FCC precipitated phase is identified as TiO, due to the introduction of O during the preparing process of HEA...
April 25, 2018: Materials
Gyu-Bong Cho, Hea-Bin Park, Jae-Seung Jeong, Myung-Rang Chae, Yeon-Min Im, Lee Han-Gyeol, Park Sang-Hui, Ki-Won Kim
Ball-milling process was applied to increase sulfur content in sulfur/polyacrylonitrile (SPAN) composites and improve electrochemical properties of Li/S batteries. In contrast to as-received PAN, pre-heated PAN was pulverized by the ball-milling, resulting in the continuous size reduction with increasing the milling time. Sulfur contents in SPAN composites synthesized with a pre-heated and milled PAN were increased with prolonging the milling time and the maximum content reached 44.5% for the milling time of 10 h...
September 1, 2018: Journal of Nanoscience and Nanotechnology
Jong-Woon Ha, Hea Jung Park, Junhoo Park, Inwon Lee, Hyun Park, Hoyoul Kong, Jong Mok Park, Do-Hoon Hwang
A series of polystyrene (PS) copolymers containing 2,3,4,5,6-pentafluorostyrene units with different monomer ratios were prepared for antifouling applications. PS, poly(styrene-co-pentafluorostyrene) (poly(S-co-FS)), and poly(pentafluorostyrene) (PFS) were synthesized by free-radical polymerization and characterized by 1H NMR, Fourier-transform infrared spectroscopy, and gel permeation chromatography. The surface energy of the polymer films decreased with increasing content of fluorinated styrene. Protein adsorption experiments were carried out on the synthesized polymer films using fluorescein isothiocyanate-labeled bovine serum albumin as a fluorescent protein...
September 1, 2018: Journal of Nanoscience and Nanotechnology
Hea Yoon Kwon, Young Kyoung Park, Sun Myoung Lee, Ji Hyeon Baek, Jae-Seung Kang, Moon-Hyun Chung, Eun Ji Kim, Jin-Soo Lee
Bartonella henselae, a gram-negative bacterium, is a common causative agent of zoonotic infections. We report 5 culture-proven cases of B. henselae infection in South Korea. By alignment of the 16S rRNA sequences and multilocus sequencing typing analysis, we identified all isolates as B. henselae Houston-1 strain, which belongs to sequence type 1.
May 2018: Emerging Infectious Diseases
Hea Lin Oh, Jun Ah Lee, Dong Ho Kim, Jung Sub Lim
Background: Ferritin reference values vary by age, gender, and ethnicity. We aimed to determine reference values of serum ferritin (SF) and the percentage of transferrin saturation (TSAT) for Korean children and adolescents. Methods: We analyzed data from 2,487 participants (1,311 males and 1,176 females) aged 10-20 years from the Korea National Health and Nutrition Examination Survey (2010-2012). We calculated age- and gender-stratified means and percentile values for SF and TSAT...
March 2018: Blood Research
Dong-Seok Lee, Sook-Jin Kim, Go-Wun Choi, Yong-Bok Lee, Hea-Young Cho
This study developed the pharmacokinetic (PK)-pharmacodynamic (PD) model of the testosterone-suppressive effect of leuprolide for evaluation of the sustained release (SR) depot and leuprolide solution in rats with or without prostate cancer. Six groups of rats were divided by the routes of administration (intravenous and subcutaneous injection) and kinds of formulation (vehicle, leuprolide solution, and SR depot). The PK profile after subcutaneous injection of leuprolide solution could be well-described by the one-compartment model...
April 15, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Laurent Misery, Julien Seneschal, Ziad Reguiai, Stéphanie Merhand, Stéphane Héas, Flavien Huet, Charles Taïeb, Khaled Ezzedine
No abstract text is available yet for this article.
April 12, 2018: Acta Dermato-venereologica
Hea-Young Cho, Lien Ngo, Sang-Ki Kim, Yoonho Choi, Yong-Bok Lee
OBJECTIVE: This study was conducted to determine whether a fixed-dose combination (FDC) tablet of repaglinide/metformin (2/500 mg) is equivalent to coadministration of equivalent doses of individual (EDI) tablets of repaglinide (2 mg) and metformin (500 mg) in healthy Korean male subjects. MATERIALS AND METHODS: This study was conducted as an open-label, randomized, single-dose, two-period, two-sequence crossover design in 50 healthy Korean male subjects who received an FDC tablet or EDI tablets...
April 12, 2018: International Journal of Clinical Pharmacology and Therapeutics
Ji-Eun Lee, Sihan Song, Eunyoung Cho, Hee Jung Jang, Heeja Jung, Hea-Young Lee, Sue Kim, Oksoo Kim, Jung Eun Lee
OBJECTIVE: We examined the associations between anthropometric measures and uterine leiomyomas. METHODS: We included a total of 5,062 women (median age of 35.5 years) who had experienced pregnancy and, of these women, 210 reported a diagnosis of uterine leiomyomas within the past 2 years in the Korea Nurses' Health Study. Participants were asked about their anthropometric factors. We calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) using logistic regression models...
April 6, 2018: Current Medical Research and Opinion
James Utama Surjadi, Libo Gao, Ke Cao, Rong Fan, Yang Lu
Mechanical metamaterials such as microlattices are an emerging kind of new materials that utilize the combination of structural enhancement effect by geometrical modification and the intrinsic properties of its material constituents. Prior studies have reported the mechanical properties of ceramic or metal-coated composite lattices. However, the scalable synthesis and characterization of high-entropy alloy (HEA) as thin film coating for such cellular materials have not been studied previously. In this work, stereolithography was combined with Radio Frequency (RF) magnetron sputtering to conformally deposit a thin layer (~800 nm) of CrMnFeCoNi HEA film onto a polymer template to produce HEA-coated three-dimensional (3D) core-shell microlattice structures for the first time...
April 3, 2018: Scientific Reports
Lien Ngo, Hea-Young Cho, Yong-Bok Lee
Fixed dose combination (FDC) of valsartan (VAL) and hydrochlorothiazide (HCT) or VAL and amlodipine (AML) has been available in many countries for the treatment of hypertension. Due to drug-drug interaction potentials, in the current study we aimed to evaluate potent effects of HCT and AML on pharmacokinetics (PKs) of VAL when they are orally co-administered as FDC (VAL/HCT at 80/12.5 mg or 160/12.5 mg; and VAL/AML at 160/5 mg or 160/10 mg) products in healthy Korean subjects. Population pharmacokinetic (PK) modeling and analysis were performed by the nonlinear mixed-effects modeling software...
March 28, 2018: European Journal of Pharmaceutical Sciences
Jiao Zhao, Jing An, Shi Liu
Background: The loss of interstitial cells of Cajal (ICC) is observed in diabetic gastroparesis. Electroacupuncture (EA) maintains ICC networks, but the effects and mechanisms of EA on ICC of bone marrow derivation in the stomach have not been investigated. Methods: C57BL/6 mice were randomized into six groups: control, diabetic (DM), bone marrow transplantation (BMT) + DM, BMT + DM + sham EA (SEA), BMT + DM + low-frequency EA (LEA), and BMT + DM + high-frequency (HEA)...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
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