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https://www.readbyqxmd.com/read/28323759/hypercapnia-caused-by-a-therapeutic-dosage-of-pregabalin-in-a-tetraplegic-patient-with-cervical-spinal-cord-injury
#1
Kyung Hee Do, Eun Jung Choi, Min Cheol Chang, Hea-Eun Yang
Pregabalin is often used for the treatment of neuropathic pain in patients with spinal cord injury (SCI). We reported a patient with C5 [S(C5/C6)] ASIA Impairment Scale C SCI due to cervical myelopathy who presented CO2 retention when taking a therapeutic dosage of pregabalin. An 88-year-old patient with cervical SCI was transferred to the department of physical medicine and rehabilitation. When he had transferred, his neuropathic pain had been treated with 150-mg pregabalin per day (75 mg twice a day); however, he still exhibited severe neuropathic pain with a Numeric Pain Rating Scale score of 7 to 8...
March 20, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28316019/population-pharmacokinetic-analysis-of-rebamipide-in-healthy-korean-subjects-with-the-characterization-of-atypical-complex-absorption-kinetics
#2
Lien Ngo, Hee-Doo Yoo, Phuong Tran, Hea-Young Cho, Yong-Bok Lee
In this study, the population pharmacokinetic (PK) analysis of rebamipide (Reba) in healthy male Korean subjects was analyzed using the nonlinear mixed effects modeling method. The possible effects of physiological covariates and the multidrug resistance (MDR1) gene 3435C>T polymorphism on PK parameters were also investigated. Data were collected from a bioequivalence study, in which 26 subjects who participated in the study were administered a single oral dose of 100 mg Reba; only data from the reference formulation were used...
March 18, 2017: Journal of Pharmacokinetics and Pharmacodynamics
https://www.readbyqxmd.com/read/28296758/the-incidence-and-clinical-characteristics-by-gender-differences-in-patients-with-kikuchi-fujimoto-disease
#3
In Young Jung, Hea Won Ann, Jung Ju Kim, Se Ju Lee, Jinnam Kim, Hye Seong, Dong Hyun Oh, Yong Chan Kim, Eun Jin Kim, Su Jin Jeong, Nam Su Ku, Jun Yong Choi, Young Goo Song, June Myung Kim
Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting disorder that typically affects the cervical lymph nodes (LNs). Although initially described in young women, KFD also occurs in men. There are no reports on the clinical manifestations and characteristics of male KFD patients. Therefore, this study was conducted to assess the incidence of KFD among males, as well as the most frequent clinical characteristics of these patients. A retrospective, cross-sectional study was performed at a tertiary hospital of patients pathologically confirmed as having KFD from LN biopsy specimens...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28275826/lower-jump-power-rather-than-muscle-mass-itself-is-associated-with-vertebral-fracture-in-community-dwelling-elderly-korean-women
#4
Eun Young Lee, Su Jin Lee, Kyoung Min Kim, Da Hea Seo, Seung Won Lee, Han Sol Choi, Hyeon Chang Kim, Yoosik Youm, Chang Oh Kim, Yumie Rhee
Sarcopenia is considered to be a risk factor for osteoporotic fracture, which is a major health problem in elderly women. In this study, we aimed to investigate the association of sarcopenia, with regard to muscle mass and function, with prevalent vertebral fracture in community-dwelling elderly women. We recruited 1281 women aged 64 to 87 years from the Korean Urban Rural Elderly cohort study. Muscle mass and function were measured using bioimpedance analysis and jumping mechanography. Skeletal muscle index (SMI) and jump power were used as an indicator of muscle mass and function, respectively...
March 9, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28272250/oxycodone-versus-fentanyl-for-intravenous-patient-controlled-analgesia-after-laparoscopic-supracervical-hysterectomy-a-prospective-randomized-double-blind-study
#5
Nan Seol Kim, Jeong Seok Lee, Su Yeon Park, Aeli Ryu, Hea Rim Chun, Ho Soon Chung, Kyou Sik Kang, Jin Hun Chung, Kyung Taek Jung, Seong Taek Mun
BACKGROUND: Oxycodone, a semisynthetic thebaine derivative opioid, is widely used for the relief of moderate to severe pain. The aim of this study was to compare the efficacy and side effects of oxycodone and fentanyl in the management of postoperative pain by intravenous patient-controlled analgesia (IV-PCA) in patients who underwent laparoscopic supracervical hysterectomy (LSH). METHODS: The 127 patients were randomized to postoperative pain treatment with either oxycodone (n = 64, group O) or fentanyl group (n = 63, group F)...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28263819/cortisol-plays-a-role-in-the-high-environmental-ammonia-associated-suppression-of-the-immune-response-in-zebrafish
#6
A F Gonçalves, J V Neves, J Coimbra, P Rodrigues, M M Vijayan, J M Wilson
Exposure to high environmental ammonia (HEA) levels increases the vulnerability of fishes to parasitic, viral and bacterial diseases. We tested the hypothesis that elevated plasma cortisol levels play a role in the HEA-mediated immunosuppression in fishes. To this end, we tested the effect of exogenous cortisol treatment on the lipopolysaccharide (LPS)-induced immune response in zebrafish (Danio rerio). Also, to test whether glucocorticoid receptor (GR) signaling is involved in HEA-mediated immunosuppression, zebrafish were treated with mifepristone, a GR antagonist, and the LPS-induced immune response assessed after HEA exposure...
March 2, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28260151/the-effects-of-acute-copper-and-ammonia-challenges-on-ammonia-and-urea-excretion-by-the-blue-crab-callinectes-sapidus
#7
Alex M Zimmer, Marianna Basso Jorge, Chris M Wood, Camila M G Martins, Adalto Bianchini
Copper (Cu) is a persistent environmental contaminant that elicits several physiological disturbances in aquatic organisms, including a disruption in ammonia regulation. We hypothesized that exposure to Cu in a model crustacean (blue crab, Callinectes sapidus) acclimated to brackish water (2 ppt) would lead to hyperammonemia by stimulating an increase in ammonia production and/or by inhibiting ammonia excretion. We further hypothesized that urea production would represent an ammonia detoxification strategy in response to Cu...
April 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28247994/a-novel-soft-sensor-approach-for-estimating-individual-biomass-in-mixed-cultures
#8
Kyle A Stone, Devarshi Shah, Min Hea Kim, Nathan R M Roberts, Q Peter He, Jin Wang
Due to many advantages associated with mixed cultures, the application of mixed cultures in biotechnology has expanded rapidly in recent years. At the same time, many challenges remain for effective mixed culture applications. One obstacle is how to efficiently and accurately monitor the individual cell populations. The current approaches on individual cell mass quantification are suitable for off-line, infrequent characterization. In this work, we propose a fast and accurate 'soft sensor' approach for estimating individual cell concentrations in mixed cultures...
March 1, 2017: Biotechnology Progress
https://www.readbyqxmd.com/read/28243443/health-education-and-activity-lessening-the-inequalities-in-mental-health-hea-lti-mental-health
#9
Georgia Richmond, Conor Kenny, Jabed Ahmed, Lucy Stephenson, Jamie Lindsay, Patrick Earls, Donncha Mullin, Howard Ryland
Patients suffering from mental health illness have considerably more physical health disease burden than the rest of the population and are more likely to die 10 to 20 years younger compared with their peers. Diabetes, cardiovascular and respiratory disease have been recognised as contributing factors to premature death. Furthermore patients with severe mental illness undertake lower levels of physical activity. The aim of the project was therefore to address the inequalities in physical health that affect patients with mental health illness through designing and implementing a sustainable, transferable, patient-centred education and activity intervention...
2017: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/28242536/importance-of-chemical-binding-type-between-as-and-iron-oxide-on-bioaccessibility-in-soil-test-with-synthesized-two-line-ferrihydrite
#10
Seulki Jeong, Kyung Yang, Eun Hea Jho, Kyoungphile Nam
Bioaccessible concentrations of As associated with Fe oxide as different chemical binding types were determined in soils using the in vitro Physiologically Based Extraction Test (PBET). When compared to the five-step sequential extraction data, most of the As extracted by in vitro PBET originated from the amorphous Fe oxide-bound fraction, and more importantly, the bioaccessibility of As ranged from 0 to 58.8% in 24 soil samples. Two batches of ferrihydrite were synthesized separately. For one batch, As was adsorbed onto the ferrihydrite after synthesis; for the other one, As was added while synthesizing ferrihydrite to co-precipitate...
February 7, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28235639/transcriptomic-analysis-of-liver-from-grass-carp-ctenopharyngodon-idellus-exposed-to-high-environmental-ammonia-reveals-the-activation-of-antioxidant-and-apoptosis-pathways
#11
Jiali Jin, Yao Wang, Zhixin Wu, Abeer Hergazy, Jiangfeng Lan, Lijuan Zhao, Xiaoling Liu, Nan Chen, Li Lin
High concentration of ammonia in aquatic system leads to detrimental effects on the health of aquatic animals. However, the mechanism underlying ammonia-induced toxicity is still not clear. To better understand the mechanism of ammonia toxicity effects on fish, juvenile grass carp was employed in the present study. RNA high-throughput sequencing technique was applied to analyze the total RNAs extracted from the liver of fish after 8 h post exposure to the water containing 2 mM NH4HCO3 which experimentally mimicked the high environmental ammonia (HEA)...
February 22, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28210000/high-velocity-deformation-of-al0-3cocrfeni-high-entropy-alloy-remarkable-resistance-to-shear-failure
#12
Z Li, S Zhao, H Diao, P K Liaw, M A Meyers
The mechanical behavior of a single phase (fcc) Al0.3CoCrFeNi high-entropy alloy (HEA) was studied in the low and high strain-rate regimes. The combination of multiple strengthening mechanisms such as solid solution hardening, forest dislocation hardening, as well as mechanical twinning leads to a high work hardening rate, which is significantly larger than that for Al and is retained in the dynamic regime. The resistance to shear localization was studied by dynamically-loading hat-shaped specimens to induce forced shear localization...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28209986/nf-%C3%AE%C2%BAb-signaling-regulates-cell-autonomous-regulation-of-cxcl10-in-breast-cancer-4t1-cells
#13
Won Jong Jin, Bongjun Kim, Darong Kim, Hea-Young Park Choo, Hong-Hee Kim, Hyunil Ha, Zang Hee Lee
The chemokine CXCL10 and its receptor CXCR3 play a role in breast cancer metastasis to bone and osteoclast activation. However, the mechanism of CXCL10/CXCR3-induced intracellular signaling has not been fully investigated. To evaluate CXCL10-induced cellular events in the mouse breast cancer cell line 4T1, we developed a new synthetic CXCR3 antagonist JN-2. In this study, we observed that secretion of CXCL10 in the supernatant of 4T1 cells was gradually increased during cell growth. JN-2 inhibited basal and CXCL10-induced CXCL10 expression and cell motility in 4T1 cells...
February 17, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28203258/electroacupuncture-at-st36-protects-icc-networks-via-mscf-kit-etv1-signaling-in-the-stomach-of-diabetic-mice
#14
Lugao Tian, Beibei Zhu, Shi Liu
Background. Electroacupuncture (EA) at ST36 has been used to regulate gastric motility and effectively improve gastric emptying in diabetic patients. Nevertheless, the specific mechanisms underlying the efficacy of this treatment remain unknown. The aim of this study was to assess the variations of interstitial cells of Cajal (ICC) and explore the changes in mSCF/KIT-ETV1 signaling in the antrum and corpus of diabetic mice after treatment with EA. Methods. Male C57BL/6 mice were randomized into five groups: control group, diabetic group (DM), diabetic-plus-sham EA group (SEA), diabetic-plus-low-frequency EA group (LEA), and diabetic-plus-high-frequency EA group (HEA)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28185828/the-role-of-molecular-typing-and-perfect-match-transfusion-in-sickle-cell-disease-and-thalassaemia-an-innovative-transfusion-strategy
#15
Rossana Putzulu, Nicola Piccirillo, Nicoletta Orlando, Giuseppina Massini, Maddalena Maresca, Fernando Scavone, Bianca Maria Ricerca, Gina Zini
Chronic red blood cell transfusions remain an essential part of supportive treatment in patients with thalassaemia and sickle cell disease (SCD). Red blood cell (RBC) transfusions expose patients to the risk of developing antibodies: RBC alloimmunization occurs when the immune system meets foreign antigens. We created a register of extensively genotyped donors to achieve a better matched transfusion in order to reduce transfusion alloimmunization. Extended RBC antigen typing was determined and confirmed by molecular biology techniques using Human Erythrocyte Antigen (HEA) BeadChip (BioArray Solutions Ltd...
January 23, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28183676/tizrnbtamo-high-entropy-alloy-designed-for-orthopedic-implants-as-cast-microstructure-and-mechanical-properties
#16
Shao-Ping Wang, Jian Xu
Combining the high-entropy alloy (HEA) concept with property requirement for orthopedic implants, we designed a Ti20Zr20Nb20Ta20Mo20 equiatomic HEA. The arc-melted microstructures, compressive properties and potentiodynamic polarization behavior in phosphate buffer solution (PBS) were studied in detail. It was revealed that the as-cast TiZrNbTaMo HEA consisted of dual phases with bcc structure, major bcc1 and minor bcc2 phases with the lattice parameters of 0.3310nm and 0.3379nm, respectively. As confirmed by nanoindentation tests, the bcc1 phase is somewhat harder and stiffer than the bcc2 phase...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28181426/site-specific-difference-of-bone-geometry-indices-in-hypoparathyroid-patients
#17
Hye Sun Park, Da Hea Seo, Yumie Rhee, Sung Kil Lim
BACKGROUND: Hypoparathyroid patients often have a higher bone mineral density (BMD) than the general population. However, an increase in BMD does not necessarily correlate with a solid bone microstructure. This study aimed to evaluate the bone microstructure of hypoparathyroid patients by using hip structure analysis (HSA). METHODS: Ninety-five hypoparathyroid patients >20 years old were enrolled and 31 of them had eligible data for analyzing bone geometry parameters using HSA...
February 8, 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28177534/laboratory-diagnosis-of-clostridium-difficile-infection-comparison-of-techlab-c-diff-quik-chek-complete-xpert-c-difficile-and-multistep-algorithmic-approach
#18
Ja Young Seo, Ji Hun Jeong, Kyung Hee Kim, Jeong-Yeal Ahn, Pil-Whan Park, Yiel-Hea Seo
BACKGROUND: Clostridium difficile is a major pathogen responsible for nosocomial infectious diarrhea. We explored optimal laboratory strategies for diagnosis of C. difficile infection (CDI) in our clinical settings, a 1400-bed tertiary care hospital. METHODS: Using 191 fresh stool samples from adult patients, we evaluated the performance of Xpert C. difficile (Xpert CD), C. diff Quik Chek Complete (which simultaneously detects glutamate dehydrogenase [GDH] and C...
February 8, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28169371/novel-benzoxazole-derivatives-dcpab-and-hpab-attenuate-th1-cell-mediated-inflammation-through-t-bet-suppression
#19
Yeon Ji Oh, Darong Kim, Sera Oh, Eun Jung Jang, Hee Yeon Won, Hana Jeong, Mi Gyeong Jeong, Hea-Young Park Choo, Eun Sook Hwang
Interferon-γ (IFN-γ), a critical inflammatory cytokine, is primarily produced by T helper 1 (Th1) cells and accelerates the pathogenesis of inflammatory colitis. Pharmacological suppression of IFN-γ production attenuates dysregulated inflammatory responses and may be beneficial for treating inflammatory disease. In this study, we aimed to discover potent anti-inflammatory compounds that suppress IFN-γ production and found that the novel benzoxazole derivatives, 2-((3,4-dichlorophenyl) amino) benzo[d]xazol-5-ol (DCPAB) and 2-((3,4-hydroxyphenyl) amino) benzo[d]xazol-5-ol (HPAB), suppressed IFN-γ production by T cells...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28144641/gene-expression-of-aromatases-steroid-receptor-gnrh-and-gths-in-the-brain-during-the-formation-of-ovarian-cavity-in-red-spotted-grouper-epinephelus-akaara
#20
Hyun Kyu Kim, Jung-Hyun Kim, Hea Ja Baek, Joon Yeong Kwon
Red spotted grouper, Epinephelus akaara, is a popular aquaculture species and a protogynous hermaphrodite. Induction of artificial sex change at the time of primary sex differentiation is of interest but has not been successful due to the lack of necessary basic information. To find out the potential neuroendocrine influence on the primary sex differentiation, the expression of key genes in the brain was investigated during the formation of ovarian cavity. Expression of cyp19a1b, esr1, gnrhr1, fsh, lh and cga in the brain was positively associated with the formation of ovarian cavity, showing gradual increase as the formation proceeds...
December 2016: Balsaeng'gwa Saengsig
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