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https://www.readbyqxmd.com/read/28210000/high-velocity-deformation-of-al0-3cocrfeni-high-entropy-alloy-remarkable-resistance-to-shear-failure
#1
Z Li, S Zhao, H Diao, P K Liaw, M A Meyers
The mechanical behavior of a single phase (fcc) Al0.3CoCrFeNi high-entropy alloy (HEA) was studied in the low and high strain-rate regimes. The combination of multiple strengthening mechanisms such as solid solution hardening, forest dislocation hardening, as well as mechanical twinning leads to a high work hardening rate, which is significantly larger than that for Al and is retained in the dynamic regime. The resistance to shear localization was studied by dynamically-loading hat-shaped specimens to induce forced shear localization...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28209986/nf-%C3%AE%C2%BAb-signaling-regulates-cell-autonomous-regulation-of-cxcl10-in-breast-cancer-4t1-cells
#2
Won Jong Jin, Bongjun Kim, Darong Kim, Hea-Young Park Choo, Hong-Hee Kim, Hyunil Ha, Zang Hee Lee
The chemokine CXCL10 and its receptor CXCR3 play a role in breast cancer metastasis to bone and osteoclast activation. However, the mechanism of CXCL10/CXCR3-induced intracellular signaling has not been fully investigated. To evaluate CXCL10-induced cellular events in the mouse breast cancer cell line 4T1, we developed a new synthetic CXCR3 antagonist JN-2. In this study, we observed that secretion of CXCL10 in the supernatant of 4T1 cells was gradually increased during cell growth. JN-2 inhibited basal and CXCL10-induced CXCL10 expression and cell motility in 4T1 cells...
February 17, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28203258/electroacupuncture-at-st36-protects-icc-networks-via-mscf-kit-etv1-signaling-in-the-stomach-of-diabetic-mice
#3
Lugao Tian, Beibei Zhu, Shi Liu
Background. Electroacupuncture (EA) at ST36 has been used to regulate gastric motility and effectively improve gastric emptying in diabetic patients. Nevertheless, the specific mechanisms underlying the efficacy of this treatment remain unknown. The aim of this study was to assess the variations of interstitial cells of Cajal (ICC) and explore the changes in mSCF/KIT-ETV1 signaling in the antrum and corpus of diabetic mice after treatment with EA. Methods. Male C57BL/6 mice were randomized into five groups: control group, diabetic group (DM), diabetic-plus-sham EA group (SEA), diabetic-plus-low-frequency EA group (LEA), and diabetic-plus-high-frequency EA group (HEA)...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28185828/the-role-of-molecular-typing-and-perfect-match-transfusion-in-sickle-cell-disease-and-thalassaemia-an-innovative-transfusion-strategy
#4
Rossana Putzulu, Nicola Piccirillo, Nicoletta Orlando, Giuseppina Massini, Maddalena Maresca, Fernando Scavone, Bianca Maria Ricerca, Gina Zini
Chronic red blood cell transfusions remain an essential part of supportive treatment in patients with thalassaemia and sickle cell disease (SCD). Red blood cell (RBC) transfusions expose patients to the risk of developing antibodies: RBC alloimmunization occurs when the immune system meets foreign antigens. We created a register of extensively genotyped donors to achieve a better matched transfusion in order to reduce transfusion alloimmunization. Extended RBC antigen typing was determined and confirmed by molecular biology techniques using Human Erythrocyte Antigen (HEA) BeadChip (BioArray Solutions Ltd...
January 23, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28183676/tizrnbtamo-high-entropy-alloy-designed-for-orthopedic-implants-as-cast-microstructure-and-mechanical-properties
#5
Shao-Ping Wang, Jian Xu
Combining the high-entropy alloy (HEA) concept with property requirement for orthopedic implants, we designed a Ti20Zr20Nb20Ta20Mo20 equiatomic HEA. The arc-melted microstructures, compressive properties and potentiodynamic polarization behavior in phosphate buffer solution (PBS) were studied in detail. It was revealed that the as-cast TiZrNbTaMo HEA consisted of dual phases with bcc structure, major bcc1 and minor bcc2 phases with the lattice parameters of 0.3310nm and 0.3379nm, respectively. As confirmed by nanoindentation tests, the bcc1 phase is somewhat harder and stiffer than the bcc2 phase...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28181426/site-specific-difference-of-bone-geometry-indices-in-hypoparathyroid-patients
#6
Hye Sun Park, Da Hea Seo, Yumie Rhee, Sung Kil Lim
BACKGROUND: Hypoparathyroid patients often have a higher bone mineral density (BMD) than the general population. However, an increase in BMD does not necessarily correlate with a solid bone microstructure. This study aimed to evaluate the bone microstructure of hypoparathyroid patients by using hip structure analysis (HSA). METHODS: Ninety-five hypoparathyroid patients >20 years old were enrolled and 31 of them had eligible data for analyzing bone geometry parameters using HSA...
February 8, 2017: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28177534/laboratory-diagnosis-of-clostridium-difficile-infection-comparison-of-techlab-c-diff-quik-chek-complete-xpert-c-difficile-and-multistep-algorithmic-approach
#7
Ja Young Seo, Ji Hun Jeong, Kyung Hee Kim, Jeong-Yeal Ahn, Pil-Whan Park, Yiel-Hea Seo
BACKGROUND: Clostridium difficile is a major pathogen responsible for nosocomial infectious diarrhea. We explored optimal laboratory strategies for diagnosis of C. difficile infection (CDI) in our clinical settings, a 1400-bed tertiary care hospital. METHODS: Using 191 fresh stool samples from adult patients, we evaluated the performance of Xpert C. difficile (Xpert CD), C. diff Quik Chek Complete (which simultaneously detects glutamate dehydrogenase [GDH] and C...
February 8, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28169371/novel-benzoxazole-derivatives-dcpab-and-hpab-attenuate-th1-cell-mediated-inflammation-through-t-bet-suppression
#8
Yeon Ji Oh, Darong Kim, Sera Oh, Eun Jung Jang, Hee Yeon Won, Hana Jeong, Mi Gyeong Jeong, Hea-Young Park Choo, Eun Sook Hwang
Interferon-γ (IFN-γ), a critical inflammatory cytokine, is primarily produced by T helper 1 (Th1) cells and accelerates the pathogenesis of inflammatory colitis. Pharmacological suppression of IFN-γ production attenuates dysregulated inflammatory responses and may be beneficial for treating inflammatory disease. In this study, we aimed to discover potent anti-inflammatory compounds that suppress IFN-γ production and found that the novel benzoxazole derivatives, 2-((3,4-dichlorophenyl) amino) benzo[d]xazol-5-ol (DCPAB) and 2-((3,4-hydroxyphenyl) amino) benzo[d]xazol-5-ol (HPAB), suppressed IFN-γ production by T cells...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28144641/gene-expression-of-aromatases-steroid-receptor-gnrh-and-gths-in-the-brain-during-the-formation-of-ovarian-cavity-in-red-spotted-grouper-epinephelus-akaara
#9
Hyun Kyu Kim, Jung-Hyun Kim, Hea Ja Baek, Joon Yeong Kwon
Red spotted grouper, Epinephelus akaara, is a popular aquaculture species and a protogynous hermaphrodite. Induction of artificial sex change at the time of primary sex differentiation is of interest but has not been successful due to the lack of necessary basic information. To find out the potential neuroendocrine influence on the primary sex differentiation, the expression of key genes in the brain was investigated during the formation of ovarian cavity. Expression of cyp19a1b, esr1, gnrhr1, fsh, lh and cga in the brain was positively associated with the formation of ovarian cavity, showing gradual increase as the formation proceeds...
December 2016: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/28137230/proteases-in-mosquito-borne-diseases-new-avenues-in-drug-development
#10
A Pant, R Pasupureddy, V Pande, S Seshadri, R Dixit, K C Pandey
Mosquito borne diseases continue to propagate and cause millions of deaths annually. They are caused either by protozoan parasites such as Plasmodium, Toxoplasma or by flaviviruses including Dengue and Zika. Among the proteome of such parasitic organisms, proteases play essential roles in events such as host invasion, hemoglobin hydrolysis, replication and immune evasion. Plasmepsin V (PMV), an endoplasmic reticulum resident aspartic protease of Plasmodium spp., is involved in the export of ~400 proteins containing the conserved Plasmodium Export Element motif (PEXEL)...
30, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28129766/severe-plasmodium-vivax-infection-in-korea
#11
Jae Hyoung Im, Hea Yoon Kwon, JiHyeon Baek, Seong Wook Park, Areum Durey, Kyung Hee Lee, Moon-Hyun Chung, Jin-Soo Lee
BACKGROUND: Although severe malaria by Plasmodium vivax has been increasingly reported, there are marked variations in the type and rate of the complications by geographic area. This is possibly because of the presence of concurrent falciparum malaria or bacteraemia, and of differences in underlying immune status among the infected subjects. Furthermore, published studies on P. vivax in temperate regions are limited. The present study investigated severe vivax malaria in Korea, where only vivax malaria occurs...
January 28, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28125236/nanocrystalline-high-entropy-alloys-a-new-paradigm-in-high-temperature-strength-and-stability
#12
Yu Zou, Jeffrey M Wheeler, Huan Ma, Philipp Okle, Ralph Spolenak
Metals with nanometer-scale grains or nanocrystalline metals exhibit high strengths at ambient conditions, yet their strengths substantially decrease with increasing temperature, rendering them unsuitable for usage at high temperatures. Here, we show that a nanocrystalline high-entropy alloy (HEA) retains an extraordinarily high yield strength over 5 GPa up to 600 °C, 1 order of magnitude higher than that of its coarse-grained form and 5 times higher than that of its single-crystalline equivalent. As a result, such nanostructured HEAs reveal strengthening figures of merit-normalized strength by the shear modulus above 1/50 and strength-to-density ratios above 0...
February 9, 2017: Nano Letters
https://www.readbyqxmd.com/read/28120568/long-pentraxin-3-as-a-predictive-marker-of-mortality-in-severe-septic-patients-who-received-successful-early-goal-directed-therapy
#13
Sun Bean Kim, Kyoung Hwa Lee, Ji Un Lee, Hea Won Ann, Jin Young Ahn, Yong Duk Jeon, Jung Ho Kim, Nam Su Ku, Sang Hoon Han, Jun Yong Choi, Young Goo Song, June Myung Kim
PURPOSE: Pentraxin 3 (PTX3) has been suggested to be a prognostic marker of mortality in severe sepsis. Currently, there are limited data on biomarkers including PTX3 that can be used to predict mortality in severe sepsis patients who have undergone successful initial resuscitation through early goal-directed therapy (EGDT). MATERIALS AND METHODS: A prospective cohort study was conducted among 83 severe sepsis patients with fulfillment of all EGDT components and the achievement of final goal...
March 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28119831/increased-bolus-volume-effect-on-delayed-pharyngeal-swallowing-response-in-post-stroke-oropharyngeal-dysphagia-a-pilot-study
#14
Jin-Woo Park, Gyu-Jeong Sim, Dong-Chan Yang, Kyoung-Hwan Lee, Ji-Hea Chang, Ki-Yeun Nam, Ho-Jun Lee, Bum-Sun Kwon
OBJECTIVE: To confirm a relationship between the pharyngeal response and bolus volume, and examine whether increasing the fluid bolus volume can improve penetration and aspiration for stroke dysphagic patients. METHODS: Ten stroke patients with a delayed pharyngeal response problem confirmed by a videofluoroscopic swallowing study (VFSS) were enrolled. Each subject completed two swallows each of 2 mL, 5 mL, and 10 mL of barium liquid thinned with water. The pharyngeal delay time (PDT) and penetration-aspiration scale (PAS) were measured and the changes among the different volumes were analyzed...
December 2016: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28079175/interstitial-atoms-enable-joint-twinning-and-transformation-induced-plasticity-in-strong-and-ductile-high-entropy-alloys
#15
Zhiming Li, Cemal Cem Tasan, Hauke Springer, Baptiste Gault, Dierk Raabe
High-entropy alloys (HEAs) consisting of multiple principle elements provide an avenue for realizing exceptional mechanical, physical and chemical properties. We report a novel strategy for designing a new class of HEAs incorporating the additional interstitial element carbon. This results in joint activation of twinning- and transformation-induced plasticity (TWIP and TRIP) by tuning the matrix phase's instability in a metastable TRIP-assisted dual-phase HEA. Besides TWIP and TRIP, such alloys benefit from massive substitutional and interstitial solid solution strengthening as well as from the composite effect associated with its dual-phase structure...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28077828/-hospital-arrival-rate-within-golden-time-and-factors-influencing-prehospital-delays-among-patients-with-acute-myocardial-infarction
#16
Hye Mi Ahn, Hyeongsu Kim, Kun Sei Lee, Jung Hyun Lee, Hyo Seon Jeong, Soung Hoon Chang, Kyeong Ryong Lee, Sung Hea Kim, Eun Young Shin
PURPOSE: This research was done to identify the hospital arrival rate and factors related to prehospital delay in arriving at an emergency medical center within the golden time after symptom onset in patients with acute myocardial infarction (AMI). METHODS: Data used in the research was from the National Emergency Department Information System of the National Emergency Medical Center which reported that in 2014, 9,611 patients went to emergency medical centers for acute myocardial infarction...
December 2016: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/28064067/simultaneous-determination-of-imperatorin-and-its-metabolite-xanthotoxol-in-rat-plasma-and-urine-by-lc-ms-ms-and-its-application-to-pharmacokinetic-studies
#17
Lien Ngo, Phuong Tran, Seong-Ho Ham, Jung-Hee Cho, Hea-Young Cho, Yong-Bok Lee
An accurate, precise, selective, and sensitive liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneous determination of imperatorin (IMP) and its metabolite, xanthotoxol (XAN), in rat plasma and urine samples. The analytes, along with psoralen as an internal standard, were determined by multiple reaction monitoring (MRM) operated in the positive electrospray ionization (ESI) mode. Chromatographic separation was performed on an Acquity UPLC BEH C18 column (50mm×2...
December 28, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28063438/ground-state-properties-of-weakly-bound-helium-alkali-trimers
#18
P Stipanović, L Vranješ Markić, D Zarić, J Boronat
Weakly bound triatomic molecules consisting of two helium atoms and one alkali metal atom are studied by means of the diffusion Monte Carlo method. We determined the stability of (4)He2A, (4)He(3)HeA, and (3)He2A, where A is one of the alkali atoms Li, Na, K, Rb, or Cs. Some of the trimers with (3)He are predicted to be self-bound for the first time, but this is observed to be dependent on the He-A interaction potential model. In addition to the ground-state energy of the trimers, we determined their density, radial, and angular distributions...
January 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28061469/diagnosis-of-cytomegalovirus-pneumonia-by-quantitative-polymerase-chain-reaction-using-bronchial-washing-fluid-from-patients-with-hematologic-malignancies
#19
Hwa Young Lee, Chin Kook Rhee, Joon Young Choi, Hea Yon Lee, Jong Wook Lee, Dong Gun Lee
BACKGROUND: The incidence of cytomegalovirus (CMV) pneumonia is increasing in patients diagnosed with hematologic malignancies. The utility of CMV-DNA viral load measurement has not been standardized, and viral cut-off values have not been established. This study was designed to investigate the utility of CMV quantitative real-time PCR (qRT-PCR) using bronchial washing fluid. METHODS: We retrospectively reviewed the microbiologic and pathologic results of bronchial washing fluid and biopsy specimens in addition to the patients' clinical characteristics...
January 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28059106/the-effect-of-electronic-structure-on-the-phases-present-in-high-entropy-alloys
#20
Zhaoyuan Leong, Jan S Wróbel, Sergei L Dudarev, Russell Goodall, Iain Todd, Duc Nguyen-Manh
Multicomponent systems, termed High Entropy Alloys (HEAs), with predominantly single solid solution phases are a current area of focus in alloy development. Although different empirical rules have been introduced to understand phase formation and determine what the dominant phases may be in these systems, experimental investigation has revealed that in many cases their structure is not a single solid solution phase, and that the rules may not accurately distinguish the stability of the phase boundaries. Here, a combined modelling and experimental approach that looks into the electronic structure is proposed to improve accuracy of the predictions of the majority phase...
January 6, 2017: Scientific Reports
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