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Subclinical breast lesions

Ayca Gucalp, Xi K Zhou, Elise D Cook, Judy E Garber, Katherine D Crew, Julie R Nangia, Priya Bhardwaj, Dilip D Giri, Olivier Elemento, Akanksha Verma, Hanhan Wang, J Jack Lee, Lana A Vornik, Carrie Mays, Diane Weber, Valerie Sepeda, Holly O'Kane, Margaret Krasne, Samantha Williams, Patrick G Morris, Brandy M Heckman-Stoddard, Barbara K Dunn, Clifford A Hudis, Powel H Brown, Andrew J Dannenberg
Obesity, a cause of subclinical inflammation, is a risk factor for the development of postmenopausal breast cancer (BC) and is associated with poorer cancer outcomes. Docosahexaenoic acid (DHA), an omega-3 fatty acid, possesses anti-inflammatory properties. We hypothesized that treatment with DHA would reduce the expression of proinflammatory genes and aromatase, the rate-limiting enzyme for estrogen biosynthesis, in benign breast tissue of overweight/obese women. A randomized, placebo-controlled, double-blind phase II study of DHA given for 12 weeks to overweight/obese women with a history of stage I-III BC, DCIS/LCIS, Paget's disease, or proliferative benign breast disease was carried out...
February 16, 2018: Cancer Prevention Research
Vivian Youngjean Park, Eun-Kyung Kim, Min Jung Kim, Hee Jung Moon, Jung Hyun Yoon
BACKGROUND: Women with a personal history of breast cancer are at increased risk of future breast cancer events, and may benefit from supplemental screening methods that could enhance early detection of subclinical disease. However, current literature on breast magnetic resonance (MR) imaging surveillance is limited. We investigated outcomes of surveillance breast magnetic resonance (MR) imaging in women with a personal history of breast cancer. METHODS: We reviewed 1053 consecutive breast MR examinations that were performed for surveillance in 1044 women (median age, 53 years; range, 20-85 years) previously treated for breast cancer between August 2014 and February 2016...
January 22, 2018: BMC Cancer
Matteo Lazzeroni, Barbara K Dunn, Giancarlo Pruneri, Barbara Alicja Jereczek-Fossa, Roberto Orecchia, Bernardo Bonanni, Andrea DeCensi
Most patients with ductal carcinoma in situ of the breast (DCIS) are eligible for breast conservation treatment. The key management decision is whether to add radiotherapy and/or endocrine therapy to minimize the risk of a subsequent recurrence. Recent analyses indicating a lack of benefit in terms of breast cancer-associated mortality have suggested that more conservative approaches, omitting adjuvant therapy or even surgery, may be advisable in selected patients. These mortality observations are directly influenced by widespread use of mammographic screening which has opened a Pandora's box of subclinical DCIS and early invasive lesions...
April 2017: Cancer Treatment Reviews
Sophie Jacob, Atul Pathak, Denis Franck, Igor Latorzeff, Gaelle Jimenez, Olivier Fondard, Matthieu Lapeyre, Daniel Colombier, Eric Bruguiere, Olivier Lairez, Benoit Fontenel, Fabien Milliat, Radia Tamarat, David Broggio, Sylvie Derreumaux, Marianne Ducassou, Jean Ferrières, Dominique Laurier, Marc Benderitter, Marie-Odile Bernier
BACKGROUND: Radiotherapy (RT) for breast cancer presents a benefit in terms of reducing local recurrence and deaths resulting from breast cancer but it can lead to secondary effects due to the presence of neighboring cardiac normal tissues within the irradiation field. Breast RT has been shown to be associated with long-term increased risk of heart failure, coronary artery disease, myocardial infarction and finally cardiovascular death more than 10 years after RT. However, there is still a lack of knowledge for early cardiotoxicity induced by breast RT that can appear long before the onset of clinically significant cardiac events...
April 7, 2016: Radiation Oncology
Piotr Bednarski, Katarzyna Dobruch-Sobczak, Eryk Chrapowicki, Wiesław Jakubowski
Recent years have witnessed a dynamic development of mammary gland imaging techniques, particularly ultrasonography and magnetic resonance imaging. A challenge related to these studies is the increase in the precision of the anatomical assessment of breast, particularly for early detection of subclinical lesions, performance of ultrasound- guided biopsy procedures, and accurate preoperative location of pathological lesions so as to optimize the surgical treatment. Ultrasound imaging is a primary and baseline diagnostic procedure the patient with suspected pathological lesions within breast is referred to by the surgeon...
June 2015: Journal of Ultrasonography
Vincent Koppelmans, Meike W Vernooij, Willem Boogerd, Caroline Seynaeve, M Arfan Ikram, Monique M B Breteler, Sanne B Schagen
PURPOSE: Adjuvant radiotherapy and chemotherapy for breast cancer have been related to transient ischemic attacks and stroke. To date, no studies have investigated the relationship between these adjuvant therapies and subclinical cerebral small-vessel disease in survivors of breast cancer. We compared white matter lesion (WML) volume and prevalence of brain infarctions and cerebral microbleeds (CMBs) between breast cancer survivors exposed to adjuvant radiotherapy and chemotherapy (aRCeBCSs) for primary disease and a population-based reference group...
February 20, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Francesco Bertagna, Giorgio Treglia, Emanuela Orlando, Lodovica Dognini, Luca Giovanella, Ramin Sadeghi, Raffaele Giubbini
This review aims to analyse the published data on the prevalence and clinical significance of breast incidental F18-FDG uptake detected by PET or PET/CT (BIU). A comprehensive computer literature search of the PubMed/MEDLINE, Scopus and Embase databases for studies on BIU published through July 2013 was performed. Pooled prevalence and malignancy risk of BIU were calculated. The literature search revealed 42 articles, and 17 were selected. One study was excluded because of data overlap but four additional studies were found screening the references...
February 2014: Japanese Journal of Radiology
Mary L Disis, Ekram Gad, Daniel R Herendeen, Vy Phan- Lai, Kyong Hwa Park, Denise L Cecil, Megan M O'Meara, Piper M Treuting, Ronald A Lubet
A multiantigen multipeptide vaccine, targeting proteins expressed in preinvasive breast lesions, can stimulate type I CD4(+) T cells which have been shown to be deficient in both patients with breast cancer and mice that develop mammary tumors. Transgenic mice (TgMMTV-neu) were immunized with a multiantigen peptide vaccine specific for neu, insulin-like growth factor-binding protein 2 and insulin-like growth factor receptor-I at a time when some of the animals already had preinvasive lesions (18 weeks of age)...
December 2013: Cancer Prevention Research
Farida Chentli, Chentli Farida, Faiza Belhimer, Belhimer Faiza
Gynecomastia is the most bothersome side effect in men taking antiandrogens. It is exceptionally severe and distressing physically and mentally as in the reported case. A man, aged 63, with a history of a well-treated macroprolactinoma, was referred in 2004 for gynecomastia that appeared after treatment by microsurgery, radiotherapy and flutamide for a lesion suspected to be prostate cancer. Clinical examination was normal except for huge enlargement of the breasts. Mammography and breasts MRI did not show any tumor...
July 2013: Indian Journal of Endocrinology and Metabolism
Maria Dalamaga, George Sotiropoulos, Konstantinos Karmaniolas, Nicolaos Pelekanos, Evangelia Papadavid, Antigoni Lekka
OBJECTIVE: Previous few studies have shown that resistin is significantly elevated in breast cancer (BC) patients. Therefore, we investigated whether serum resistin could be used as a potential diagnostic and prognostic tool for postmenopausal BC (PBC), taking into account clinicopathological features, serum tumor markers, anthropometric, metabolic, and, for the first time, inflammatory parameters. METHODS: Serum resistin, tumor markers (CA 15-3 and CEA), metabolic, anthropometric and inflammatory parameters (TNF-α, IL-6, hsCRP) were determined in 103 postmenopausal women with incident, pathologically confirmed, invasive BC, 103 controls matched on age and time of diagnosis, and 51 patients with benign breast lesions (BBL)...
May 2013: Clinical Biochemistry
Kalyan Das, Diptendra Kumar Sarkar, Rejaul Karim, Asim Kumar Manna
BACKGROUND: Breast cancer is a major cause of cancer-related morbidity and mortality in Indian women. Most cases present late and thus survival in Indian patients is poor compared to the western world. In the absence of a screening, early detection of breast cancer is a challenge in Indian subcontinent. METHOD: Though much is known about management of any palpable lump in breast, clear guidelines in dealing with non-palpable lesions of breast is still obscure. Careful imaging of breast followed by assignment of standard Breast Imaging Reporting and Data Systems (BIRADS) category to the finding can go in a long way to predict chances of malignancy in a non-palpable breast lesion (NPBL)...
April 2010: Indian Journal of Surgery
C Rua, P Lebas, P Michenet, L Ouldamer
PURPOSE: To determine the diagnostic performance of radiological evaluation of the margins of surgical specimens from lumpectomies for subclinical malignant breast lesions. MATERIALS AND METHODS: Retrospective study in two French hospitals including all patients who had a non-palpable in situ (ISDC) or invasive (IDC) ductal carcinoma treated by lumpectomy after radiological localisation. For the analysis, the lesions were divided into two groups depending on the majority component in the definitive histological examination: ISDC or IDC...
November 2012: Diagnostic and Interventional Imaging
Guglielmo Manenti, Tommaso Perretta, Eleonora Gaspari, Chiara A Pistolese, Lia Scarano, Elsa Cossu, Elena Bonanno, Oreste C Buonomo, Giuseppe Petrella, Giovanni Simonetti, Salvatore Masala
OBJECTIVES: To assess the ablative effectiveness, the oncological and cosmetic efficacy of image-guided percutaneous cryoablation in the treatment of single breast nodules with subclinical dimensions after identification with ultrasonography (US), mammography, magnetic resonance (MRI) and characterization by vacuum assisted biopsy. MATERIALS: Fifteen women with a mean age of 73 ± 5 years (range 64-82 years) and lesion diameter of 8 ± 4 mm were undergoing cryotherapy technology with a single probe under US-guidance associated with intra-procedural lymph-node mapping and excision of the sentinel node...
November 2011: European Radiology
Vincenzo Ventrella, Antonio Tufaro, Francesco A Zito, Maria Addante, Baldassarre Stea, Rosalba Dentamaro, Cosimo D'Amico, Angelo Paradiso
BACKGROUND: The new imaging technology made available today allows for an early detection of small subclinical breast lesions which frequently call for guided presurgical micro-histology. PURPOSE: To evaluate the relationship between vacuum-assisted breast biopsy (VABB) histopathological diagnoses and mammographic findings in non-palpable breast lesions. MATERIAL AND METHODS: The breast lesions of 1393 women who had received consecutive screening mammograms between 2001 and 2007 were assessed by VABB...
July 1, 2011: Acta Radiologica
Jing Su, Ming-Xun Chen, Meng-Quan Li
OBJECTIVE: To investigate the value of guide wire location under mammography for a resection of subclinical breast lesions. METHODS: A total of 79 patients presenting with abnormal mammography but unpalpable lesions received a guide wire pre-operative location under mammography. And 82 lesions were successfully located and resected for pathological examination. RESULTS: All 82 lesions were located with a high accuracy. The pathological examination revealed breast fibroma (n = 4), mammary gland hyperplasia with calcification (n = 58), intraductal papilloma (n = 2), fat necrosis with calcification (n = 3), mammary atypical hyperplasia (n = 5), breast inflammation (n = 1) and breast cancer (n = 9)...
January 11, 2011: Zhonghua Yi Xue za Zhi [Chinese medical journal]
C-J Fouché, F Tabareau, P Michenet, P Lebas, E-G Simon
OBJECTIVE: This study aimed to determine the accuracy of specimen radiography in evaluating the surgical margins of impalpable breast carcinoma. DESIGN AND SETTING: Retrospective study from June 2009 to June 2010 in Orleans Hospital Center. PATIENTS AND METHODS: The study involved patients with impalpable in situ breast carcinoma diagnosed by mammography. Only patients with larger in situ carcinoma than invasive carcinoma were included. Patients underwent a breast conserving surgery after preoperative localization of the lesion...
June 2011: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
A Ancona, M Capodieci, A Galiano, F Mangieri, V Lorusso, G Gatta
PURPOSE: This study sought to evaluate the accuracy of vacuum-assisted biopsy (VAB) in the diagnosis of atypical ductal hyperplasia (ADH) by determining the rate of VAB underestimation compared with definitive histology. In addition, an attempt was made to identify parameters that could help determine the most appropriate patient management. MATERIALS AND METHODS: We retrospectively reviewed 1,776 VAB procedures performed between November 1999 and January 2008 for suspicious subclinical breast lesions visible only at mammography...
March 2011: La Radiologia Medica
Elżbieta Skowrońska-Jóźwiak, Kinga Krawczyk-Rusiecka, Zbigniew Adamczewski, Stanisław Sporny, Marek Zadrożny, Marek Dedecjus, Jan Brzeziński, Andrzej Lewiński
INTRODUCTION: Metastatic cancer is rarely found in the thyroid (only 2-3% of malignant tumours found in that gland); primary sources usually including breast, kidney, and lung tumours. CASES REPORTS: Two cases of advanced breast cancer with thyroid metastases in female patients are presented. The similarities between these two cases included: 1) postmenopausal age; 2) diagnosis based on result of FNAB (numerous groups of cells with epithelial phenotype strongly implying metastatic breast cancer); 3) thyroid function - overt hyperthyroidism in the first woman and subclinical hyperthyroidism in the second one; 4) the presence of nodular goitre in clinical examination, the occurrence of many nodular solid normoechogenic lesions with calcifications in both thyroid lobes in US; and 5) negative antithyroid antibodies...
September 2010: Endokrynologia Polska
Annemarie C Schmitz, Maurice A A J van den Bosch, Claudette E Loo, Willem P Th M Mali, Harry Bartelink, Maria Gertenbach, Roland Holland, Johannes L Peterse, Emiel J Th Rutgers, Kenneth G Gilhuijs
BACKGROUND: Magnetic resonance imaging (MRI) is more often considered to guide, evaluate or select patients for partial breast irradiation (PBI) or minimally invasive therapy. Safe treatment margins around the MRI-visible lesion (MRI-GTV) are needed to account for surrounding subclinical occult disease. PURPOSE: To precisely compare MRI findings with histopathology, and to obtain detailed knowledge about type, rate, quantity and distance of occult disease around the MRI-GTV...
November 2010: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
S Oden, S Thureau, M Baron, C Hanzen
PURPOSE: The main objective was to assess contributions and limits of surgical clips combined with computed tomography to define the tumor bed after conservative treatment of breast cancer. This retrospective observational study enrolled 16 patients treated by lumpectomy with surgical clips placed in the tumor bed. PATIENTS AND METHODS: We assessed the difficulties in localizing the tumour bed based on collected data (i.e. clinical description, mammography, ultrasound examination, surgical procedure and pathology data)...
April 2010: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
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