keyword
https://read.qxmd.com/read/38254870/prediction-of-subclinical-and-clinical-multiple-organ-failure-dysfunction-in-breast-cancer-patients-a-review-using-ai-tools
#1
REVIEW
Andreea-Iuliana Ionescu Miron, Dimitrie-Ionut Atasiei, Radu-Tudor Ionescu, Flavia Ultimescu, Andrei-Alexandru Barnonschi, Alexandra-Valentina Anghel, Cătălin-Alexandru Anghel, Ionuț-Lucian Antone-Iordache, Ruxandra Mitre, Alexandra Maria Bobolocu, Andreea Zamfir, Horia-Dan Lișcu, Simona Coniac, Florica Șandru
This review explores the interconnection between precursor lesions of breast cancer (typical ductal hyperplasia, atypical ductal/lobular hyperplasia) and the subclinical of multiple organ failure syndrome, both representing early stages marked by alterations preceding clinical symptoms, undetectable through conventional diagnostic methods. Addressing the question "Why patients with breast cancer exhibit a tendency to deteriorate", this study investigates the biological progression from a subclinical multiple organ failure syndrome, characterized by insidious but indisputable lesions, to an acute (clinical) state resembling a cascade akin to a waterfall or domino effect, often culminating in the patient's demise...
January 16, 2024: Cancers
https://read.qxmd.com/read/37284712/clinical-experience-of-the-magseed-%C3%A2-magnetic-marker-to-localize-non-palpable-breast-lesions-a-cohort-study-of-100-consecutive-cases
#2
JOURNAL ARTICLE
Julie Crèvecoeur, Véronique Jossa, Julien Di Bella, Michel Coibion, André Crèvecoeur
BACKGROUND: The aim of this study was to report on a cohort of 100 patients where the Magseed® paramagnetic marker was used to localize non-palpable breast lesions. METHODS: Data were collected from a cohort of 100 patients with non-palpable breast lesions, who underwent localization using the Magseed® marker. This marker consists of a paramagnetic seed that can be seen on mammography or ultrasound and intraoperatively detected with the use of the Sentimag® probe...
May 30, 2023: Gland Surgery
https://read.qxmd.com/read/37173933/efficacity-of-deep-inspiration-breath-hold-and-intensity-modulated-radiotherapy-in-preventing-perfusion-defect-for-left-sided-breast-cancer-edipe-a-prospective-cohort-study-protocol
#3
JOURNAL ARTICLE
Jordan Eber, Cyrille Blondet, Martin Schmitt, David G Cox, Claire Vit, Clara Le Fèvre, Delphine Antoni, Fabrice Hubele, Georges Noel
Breast radiotherapy can lead to radiation-induced cardiac disease, particularly in left breast cancers. Recent studies have shown that subclinical cardiac lesions, such as myocardial perfusion deficits, may occur early after radiotherapy. The primary method for irradiating breast cancer, known as opposite tangential field radiotherapy, can cause the anterior interventricular coronary artery to receive a high dose of radiation during left breast irradiation. To explore alternative approaches that could reduce the risk of myocardial perfusion defects in patients with left breast cancer, we plan to conduct a prospective single-center study using a combination of deep inspiration breath hold radiotherapy and intensity modulated radiation therapy...
April 25, 2023: Cancers
https://read.qxmd.com/read/36238889/adaptive-image-rescaling-for-weakly-contrast-enhanced-lesions-in-dedicated-breast-ct-a-phantom-study
#4
JOURNAL ARTICLE
Bitbyeol Kim, Ho Kyung Kim, Jinsung Kim, Yongkan Ki, Ji Hyeon Joo, Hosang Jeon, Dahl Park, Wontaek Kim, Jiho Nam, Dong Hyeon Kim
Purpose: Dedicated breast CT is an emerging volumetric X-ray imaging modality for diagnosis that does not require any painful breast compression. To improve the detection rate of weakly enhanced lesions, an adaptive image rescaling (AIR) technique was proposed. Materials and Methods: Two disks containing five identical holes and five holes of different diameters were scanned using 60/100 kVp to obtain single-energy CT (SECT), dual-energy CT (DECT), and AIR images...
November 2021: Taehan Yŏngsang Ŭihakhoe chi
https://read.qxmd.com/read/35815973/in-vivo-imaging-to-measure-spontaneous-lung-metastasis-of-orthotopically-injected-breast-tumor-cells
#5
JOURNAL ARTICLE
Saahil Sanon, Paula D Bos
Metastasis remains the primary cause of cancer-related death. The succession of events that characterize the metastatic cascade presents multiple opportunities for therapeutic intervention, and the ability to accurately model them in mice is critical to evaluate their effects. Here, a step-by-step protocol is presented for the establishment of orthotopic primary breast tumors and the subsequent monitoring of the establishment and growth of metastatic lesions in the lung using in vivo bioluminescence imaging...
June 23, 2022: Journal of Visualized Experiments: JoVE
https://read.qxmd.com/read/35740602/a-fibrosis-biomarker-early-predicts-cardiotoxicity-due-to-anthracycline-based-breast-cancer-chemotherapy
#6
JOURNAL ARTICLE
Ana de la Fuente, Marta Santisteban, Josep Lupón, José Manuel Aramendía, Agnes Díaz, Ana Santaballa, Amparo Hernándiz, Pilar Sepúlveda, Germán Cediel, Begoña López, José María López Picazo, Manuel M Mazo, Gregorio Rábago, Juan José Gavira, Ignacio García-Bolao, Javier Díez, Arantxa González, Antoni Bayés-Genís, Susana Ravassa
Anthracycline-based cancer chemotherapy (ACC) causes myocardial fibrosis, a lesion contributing to left ventricular dysfunction (LVD). We investigated whether the procollagen-derived type-I C-terminal-propeptide (PICP): (1) associates with subclinical LVD (sLVD) at 3-months after ACC (3m-post-ACC); (2) predicts cardiotoxicity 1-year after ACC (12m-post-ACC) in breast cancer patients (BC-patients); and (3) associates with LVD in ACC-induced heart failure patients (ACC-HF-patients). Echocardiography, serum PICP and biomarkers of cardiomyocyte damage were assessed in two independent cohorts of BC-patients: CUN ( n = 87) at baseline, post-ACC, and 3m and 12m ( n = 65)-post-ACC; and HULAFE ( n = 70) at baseline, 3m and 12m-post-ACC...
June 14, 2022: Cancers
https://read.qxmd.com/read/34334143/axillary-paget-disease-with-a-visible-satellite-a-case-report-and-literature-review
#7
REVIEW
Wu-Yang Ji, Bin Luo, Xue-Wei Wang, Ying Xiao, Jin-Yi Tian
BACKGROUND: Extramammary Paget disease (EMPD) is an uncommon malignancy affecting apocrine gland-bearing skin, such as vulvar, perianal, axillary and penoscrotal areas. Paget cells are sometimes detected outside clinical border in a phenomenon called subclinical extension. Satellite is one of the patterns of subclinical extension which is likely to be invisible. The standard management strategy for EMPD without distant metastasis is a complete surgical removal, sometimes called wide local excision...
August 1, 2021: Diagnostic Pathology
https://read.qxmd.com/read/33434176/aldosterone-and-cortisol-cosecreting-adrenal-adenoma-ovarian-hyperthecosis-and-breast-cancer
#8
JOURNAL ARTICLE
John J Orrego, Joseph A Chorny
Summary: We describe a 56-year-old postmenopausal woman with hypertension, hypokalemia and severe alopecia who was found to have a 4.5-cm lipid-poor left adrenal mass on CT scan performed to evaluate her chronic right-sided abdominal pain. Hormonal studies revealed unequivocal evidence of primary aldosteronism and subclinical hypercortisolemia of adrenal origin. Although a laparoscopic left adrenalectomy rendered her normotensive, normokalemic and adrenal insufficient for 2.5 years, her alopecia did not improve and she later presented with facial hyperpigmentation acne, worsening hirsutism, clitoromegaly, and an estrogen receptor-positive breast cancer...
September 23, 2020: Endocrinology, Diabetes & Metabolism Case Reports
https://read.qxmd.com/read/32661665/spatial-location-of-local-recurrences-after-mastectomy-a-systematic-review
#9
REVIEW
Orit Kaidar-Person, Philip Poortmans, Birgitte Vrou Offersen, Sabine Siesling, Miri Sklair-Levy, Icro Meattini, Dirk de Ruysscher, Thorsten Kühn, Liesbeth J Boersma
PURPOSE: We performed a systematic review to document the spatial location of local recurrences (LR) after mastectomy. METHODS: A PubMed search was conducted in August 2019 for the following terms: breast [Title/Abstract] AND cancer [Title/Abstract] AND recurrence [Title/Abstract] AND mastectomy [Title/Abstract]. The search was filtered for English language. Exclusion criteria included studies that did not specify the LR location or studies reporting LR associated with inflammatory breast cancer, or other breast cancers such as phyllodes tumours, lymphoma or associated with sarcoma/angiosarcoma...
September 2020: Breast Cancer Research and Treatment
https://read.qxmd.com/read/31767605/recurrent-metastatic-breast-cancer-presenting-with-portal-hypertension-and-pseudocirrhosis
#10
JOURNAL ARTICLE
Maciej Adler, Ivan Tang, Michael William Gach, George MacFaul
We present a case of a 63-year-old woman with an acute history of abdominal distension and shortness of breath. She had no risk factors for liver disease though her prior medical history was positive for breast carcinoma, in remission for 14 years. Examination and investigations were initially consistent with decompensated cirrhosis, thought to be due to subclinical autoimmune hepatitis. Imaging revealed hepatic contour irregularity, atrophy of the liver parenchyma and numerous lesions highly suggestive for multifocal hepatocellular carcinoma...
November 24, 2019: BMJ Case Reports
https://read.qxmd.com/read/31699706/a-multistage-murine-breast-cancer-model-reveals-long-lived-premalignant-clones-refractory-to-parity-induced-protection
#11
JOURNAL ARTICLE
Shuo Li, Shelley A Gestl, Edward J Gunther
Breast cancers evolve in a multistage process that can span decades after a carcinogenic exposure. It follows that long-lived precursor breast lesions persist in a subclinical state prior to completing malignant transformation, yet widely-used breast cancer models lack an experimental framework for targeting premalignant disease. Inspired by classic multistage skin carcinogenesis protocols, we combined chemical carcinogenesis with transgenic mouse modeling to resolve mouse mammary carcinogenesis into discrete initiation and progression stages...
November 7, 2019: Cancer Prevention Research
https://read.qxmd.com/read/30915855/temporal-characterization-of-wooden-breast-myopathy-woody-breast-severity-and-correlation-with-growth-rate-and-lymphocytic-phlebitis-in-three-commercial-broiler-strains-and-a-random-bred-broiler-strain
#12
JOURNAL ARTICLE
Laura R Chen, M Mitsu Suyemoto, Albarra H Sarsour, H Alejandro Cordova, Edgar O Oviedo-Rondón, Michael Wineland, H John Barnes, Luke B Borst
Wooden breast myopathy (WBM), or "woody breast" or "wooden breast" affects modern, rapidly growing, high breast-yield broiler chickens. Decreased meat quality due to undesirable organoleptic properties and condemnation of affected breast meat cause economic losses. The pathogenesis of WBM remains unknown. In this study, WBM lesion development was determined in three modern broiler strains and Athens Canadian Random Bred (ACRB) broilers, a 1950s unselected broiler chicken. Correlations between WBM severity and incubation temperature profile, sex, strain, body weight, and lymphocytic phlebitis were also determined...
August 2019: Avian Pathology: Journal of the W.V.P.A
https://read.qxmd.com/read/30544617/biological-aggressiveness-of-subclinical-no-mass-ductal-carcinoma-in-situ-dcis-can-be-reflected-by-the-expression-profiles-of-epithelial-mesenchymal-transition-triggers
#13
JOURNAL ARTICLE
Bartlomiej Szynglarewicz, Piotr Kasprzak, Piotr Donizy, Przemyslaw Biecek, Agnieszka Halon, Rafal Matkowski
Epithelial-mesenchymal transitions (EMTs) have been recently implicated in the process of cancer progression. The aim of this study was to assess how the preoperative expression patterns of EMT biomarkers correlate with the risk of postoperative invasion in ductal carcinoma in situ (DCIS) found on stereotactic breast biopsies. N-cadherin, Snail1, and secreted protein acidic and rich in cysteine (SPARC) immunoreactivity was observed in 8%, 62%, and 38% of tumors, respectively. Snail1 and SPARC expressions were significantly related to N-cadherin expression and to each other...
December 7, 2018: International Journal of Molecular Sciences
https://read.qxmd.com/read/30274965/early-detection-of-cardiovascular-changes-after-radiotherapy-for-breast-cancer-protocol-for-a-european-multicenter-prospective-cohort-study-medirad-early-heart-study
#14
JOURNAL ARTICLE
Valentin Walker, Anne Crijns, Johannes Langendijk, Daan Spoor, Rozemarijn Vliegenthart, Stephanie E Combs, Michael Mayinger, Arantxa Eraso, Ferran Guedea, Manuela Fiuza, Susana Constantino, Radia Tamarat, Dominique Laurier, Jean Ferrières, Elie Mousseaux, Elisabeth Cardis, Sophie Jacob
BACKGROUND: Breast cancer is the most common cancer among women, and radiotherapy plays a major role in its treatment. However, breast cancer radiotherapy can lead to incidental irradiation of the heart, resulting in an increased risk for a variety of heart diseases arising many years after radiotherapy. Therefore, identifying breast cancer patients at the highest risk for radiation-induced cardiac complications is crucial for developing strategies for primary and secondary prevention, which may contribute to healthy aging...
October 1, 2018: JMIR Research Protocols
https://read.qxmd.com/read/29453232/a-randomized-multicenter-phase-ii-study-of-docosahexaenoic-acid-in-patients-with-a-history-of-breast-cancer-premalignant-lesions-or-benign-breast-disease
#15
JOURNAL ARTICLE
Ayca Gucalp, Xi K Zhou, Elise D Cook, Judy E Garber, Katherine D Crew, Julie R Nangia, Priya Bhardwaj, Dilip D Giri, Olivier Elemento, Akanksha Verma, Hanhan Wang, J Jack Lee, Lana A Vornik, Carrie Mays, Diane Weber, Valerie Sepeda, Holly O'Kane, Margaret Krasne, Samantha Williams, Patrick G Morris, Brandy M Heckman-Stoddard, Barbara K Dunn, Clifford A Hudis, Powel H Brown, Andrew J Dannenberg
Obesity, a cause of subclinical inflammation, is a risk factor for the development of postmenopausal breast cancer and is associated with poorer cancer outcomes. Docosahexaenoic acid (DHA), an omega-3 fatty acid, possesses anti-inflammatory properties. We hypothesized that treatment with DHA would reduce the expression of proinflammatory genes and aromatase, the rate-limiting enzyme for estrogen biosynthesis, in benign breast tissue of overweight/obese women. A randomized, placebo-controlled, double-blind phase II study of DHA given for 12 weeks to overweight/obese women with a history of stage I-III breast cancer, DCIS/LCIS, Paget's disease, or proliferative benign breast disease was carried out...
April 2018: Cancer Prevention Research
https://read.qxmd.com/read/29357842/breast-magnetic-resonance-imaging-for-surveillance-of-women-with-a-personal-history-of-breast-cancer-outcomes-stratified-by-interval-between-definitive-surgery-and-surveillance-mr-imaging
#16
JOURNAL ARTICLE
Vivian Youngjean Park, Eun-Kyung Kim, Min Jung Kim, Hee Jung Moon, Jung Hyun Yoon
BACKGROUND: Women with a personal history of breast cancer are at increased risk of future breast cancer events, and may benefit from supplemental screening methods that could enhance early detection of subclinical disease. However, current literature on breast magnetic resonance (MR) imaging surveillance is limited. We investigated outcomes of surveillance breast magnetic resonance (MR) imaging in women with a personal history of breast cancer. METHODS: We reviewed 1053 consecutive breast MR examinations that were performed for surveillance in 1044 women (median age, 53 years; range, 20-85 years) previously treated for breast cancer between August 2014 and February 2016...
January 22, 2018: BMC Cancer
https://read.qxmd.com/read/28262606/adjuvant-therapy-in-patients-with-ductal-carcinoma-in-situ-of-the-breast-the-pandora-s-box
#17
REVIEW
Matteo Lazzeroni, Barbara K Dunn, Giancarlo Pruneri, Barbara Alicja Jereczek-Fossa, Roberto Orecchia, Bernardo Bonanni, Andrea DeCensi
Most patients with ductal carcinoma in situ of the breast (DCIS) are eligible for breast conservation treatment. The key management decision is whether to add radiotherapy and/or endocrine therapy to minimize the risk of a subsequent recurrence. Recent analyses indicating a lack of benefit in terms of breast cancer-associated mortality have suggested that more conservative approaches, omitting adjuvant therapy or even surgery, may be advisable in selected patients. These mortality observations are directly influenced by widespread use of mammographic screening which has opened a Pandora's box of subclinical DCIS and early invasive lesions...
April 2017: Cancer Treatment Reviews
https://read.qxmd.com/read/27056179/early-detection-and-prediction-of-cardiotoxicity-after-radiation-therapy-for-breast-cancer-the-baccarat-prospective-cohort-study
#18
JOURNAL ARTICLE
Sophie Jacob, Atul Pathak, Denis Franck, Igor Latorzeff, Gaelle Jimenez, Olivier Fondard, Matthieu Lapeyre, Daniel Colombier, Eric Bruguiere, Olivier Lairez, Benoit Fontenel, Fabien Milliat, Radia Tamarat, David Broggio, Sylvie Derreumaux, Marianne Ducassou, Jean Ferrières, Dominique Laurier, Marc Benderitter, Marie-Odile Bernier
BACKGROUND: Radiotherapy (RT) for breast cancer presents a benefit in terms of reducing local recurrence and deaths resulting from breast cancer but it can lead to secondary effects due to the presence of neighboring cardiac normal tissues within the irradiation field. Breast RT has been shown to be associated with long-term increased risk of heart failure, coronary artery disease, myocardial infarction and finally cardiovascular death more than 10 years after RT. However, there is still a lack of knowledge for early cardiotoxicity induced by breast RT that can appear long before the onset of clinically significant cardiac events...
April 7, 2016: Radiation Oncology
https://read.qxmd.com/read/26675118/breast-ultrasound-scans-surgeons-expectations
#19
REVIEW
Piotr Bednarski, Katarzyna Dobruch-Sobczak, Eryk Chrapowicki, Wiesław Jakubowski
Recent years have witnessed a dynamic development of mammary gland imaging techniques, particularly ultrasonography and magnetic resonance imaging. A challenge related to these studies is the increase in the precision of the anatomical assessment of breast, particularly for early detection of subclinical lesions, performance of ultrasound- guided biopsy procedures, and accurate preoperative location of pathological lesions so as to optimize the surgical treatment. Ultrasound imaging is a primary and baseline diagnostic procedure the patient with suspected pathological lesions within breast is referred to by the surgeon...
June 2015: Journal of Ultrasonography
https://read.qxmd.com/read/25559803/prevalence-of-cerebral-small-vessel-disease-in-long-term-breast-cancer-survivors-exposed-to-both-adjuvant-radiotherapy-and-chemotherapy
#20
JOURNAL ARTICLE
Vincent Koppelmans, Meike W Vernooij, Willem Boogerd, Caroline Seynaeve, M Arfan Ikram, Monique M B Breteler, Sanne B Schagen
PURPOSE: Adjuvant radiotherapy and chemotherapy for breast cancer have been related to transient ischemic attacks and stroke. To date, no studies have investigated the relationship between these adjuvant therapies and subclinical cerebral small-vessel disease in survivors of breast cancer. We compared white matter lesion (WML) volume and prevalence of brain infarctions and cerebral microbleeds (CMBs) between breast cancer survivors exposed to adjuvant radiotherapy and chemotherapy (aRCeBCSs) for primary disease and a population-based reference group...
February 20, 2015: Journal of Clinical Oncology
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