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Marc Laine, Franck Paganelli, Laurent Bonello
Antiplatelet therapy is the cornerstone of the therapeutic arsenal in coronary artery disease. Thanks to a better understanding in physiology, pharmacology and pharmacogenomics huge progress were made in the field of platelet reactivity inhibition thus allowing the expansion of percutaneous coronary intervention. Stent implantation requires the combination of two antiplatelet agents acting in a synergistic way. Asprin inhibit the cyclo-oxygenase pathway of platelet activation while clopidogrel is a P2Y12 adenosine diphosphate (ADP)-receptor antagonist...
May 26, 2016: World Journal of Cardiology
Zhanqi Wang, Hongliang Cong, Zheng Li, Lanfang Zhang, Fang Zhang, Xiangxin Li
OBJECTIVE: To investigate the safety of implantation permanent pacemaker (PM) at different times in patients with dual antiplatelet (DAPT) therapy after implantation of drug-eluting stent (DES). METHODS: A total of 105 patients who implanted pacemakers with DAPT therapy (clopidogrel and aspirin) after implantation of DES admitted to our hospital from January 2009 to January 2015 were enrolled in the study. The patients were divided into 3 groups: dual antiplatelet therapy (DAP) group: implanting PM within 3 months after coronary stenting, continuous DAPT during perioperative period; low molecular weight heparin (LMWH) bridging group: implanting PM within 3 to 6 months after coronary stenting, DAPT interruption for 5 days replaced with subcutaneous injection of enoxaparin (1 mg/kg), twice per day, enoxaparin was stopped 12 h before operation; asprin group, implanting PM after coronary stenting 6 months, clopidogrel interruption for 5 days...
May 10, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Xiao-qin Ye, Yan-ming Xie, Yi-huai Zou, Xin-quan Zhao, Jian-hua Han, Xin-zhi Wang, Yun-zhi Ma, Qi Bi, Qin-fan Xie, Jian-jun Zhao, Xiao-lan Cao, Hong-xia Chen, Wang Shi-zhong, Yong-mei Yan, Zu-cheng Han, Dan-hui Yi, Yong-yan Wang
To evaluate the effect of Naoshuantong capsule on the life quality of patients with ischemic stroke in six months of follow-up studies, and observe the adverse events. The results would provide reference for the secondary prevention on the recovery stage of ischemic stroke. 696 patients from 12 Class III Grade I hospitals nationwide were divided into 2 groups by central randomization system. The study group, 344 cases, were treated with Naoshuantong capsule plus Aspirin, and the control group, 352 cases, were treated with Aspirin...
November 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Teng-fei Liu, Jing-wei Zhang, Xia-huan Chen, Xue-ru Feng, Zhong-sheng Bai, Mei-lin Liu
OBJECTIVE: To elucidate the correlation between the single nucleotide polymorphism of CKLF-like MARVEL transmembrane member 5 (CMTM5) gene rs723840 and the occurrence of high on aspirin platelet reactivity (HAPR). METHODS: The present study is a case-control study. A total of 210 hospitalized patients in Peking University First Hospital were enrolled. Aspirin response was assessed by 0.5 g/L arachidonic acid (AA)-induced platelet aggregation ratio (PR), and ≥ 3/4 quartile of PR of the population was defined as HAPR...
December 18, 2015: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
Liaqat Hussain, Muhammad S H Akash, Sabah Naseem, Kanwal Rehman, Kwaja Z Ahmed
BACKGROUND: According to an estimation of the WHO, almost 80% of people globally are treated by traditional medicine. OBJECTIVES: We evaluated the anti-ulcerogenic potential of Salmalia malabarica extract in rats using aspirin-, alcohol- and pylorus ligation-induced ulcer models. MATERIAL AND METHODS: Two different doses (200 and 400 mg/kg body weight) of Salmalia malabarica extract was administered intraperitoneally (i.p.) to all 3 ulcer-induced models for 5 consecutive days...
July 2015: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Shi-Ping Zheng, Wei Han, Hao-Ran Chu, Ying Wang, Ling Zhang, Ling-Ling Zhu, Guo-Qing Zhang, Qian-Qian Cui
OBJECTIVE: The present study aimed at observing the effect of moxibustion pretreatment on the expression of cerebral microRNAs and Aquaporin protein-4 (AQP 4) in rats with cerebral ischemia and reperfusion (CI/R), so as to reveal its mechanism underlying improvement of cerebral infarction. METHODS: A total of 130 Wistar rats were randomly divided into blank control (n = 10), CI/R model (n = 30), electroacupuncture (EA, n = 30), moxibustion (n = 30), Aspirin groups (n = 30)...
April 2015: Zhen Ci Yan Jiu, Acupuncture Research
Amin Polzin, Stefan Richter, Karsten Schrör, Tienush Rassaf, Marc W Merx, Malte Kelm, Thomas Hohlfeld, Tobias Zeus
We have recently shown that dipyrone (metamizole), a non-opioid analgesic, can nullify aspirin (acetylsalicylic acid; ASA) antiplatelet effects in patients with coronary artery disease (CAD). In this study, we analysed the aspirin and dipyrone drug-drug interaction in order to identify strategies to prevent the dipyrone induced inhibition of asprin antiplatelet effects. Platelet function was measured by arachidonic acid-induced light-transmission aggregometry, thromboxane (TX) B2- formation by immunoassay. Dipyrone metabolite plasma levels were determined by high-performance-liquid-chromatography (HPLC)...
July 2015: Thrombosis and Haemostasis
Lilly Baptista Arun, Aarrthy M Arunachalam, Kantha Deivi Arunachalam, Sathesh Kumar Annamalai, Kalaivani Amit Kumar
BACKGROUND: Gymnema sylvestre is a highly valued ethno pharmacologically important medicinal plant used currently in many poly-herbal formulations due to its potential antidiabetic activity and other health benefits. The present study was carried out to analyze the anti-stress, anti-allergic, and antiulcer activity of the bioactive compounds present in Gymnema sylvestre leaves. METHODS: The preliminary phytochemical screening for bioactive compounds from aqueous extracts revealed the presence of alkaloids, triterpenes, flavonoids, steroids, and saponins...
2014: BMC Complementary and Alternative Medicine
Qiang Fu, Shuichi Ishikawa, Naoyuki Yokoyama, Ken Kozuma, Kaoru Takada, Aki Muraki, Takaaki Isshiki
Hemodialysis ("HD") has been suggested as a risk factor for stent thrombosis. However, platelet function in HD patients after coronary stent implantation remains unclear. The aim of this study was to evaluate platelet function following coronary stent implantation in HD patients. A total of 10 HD and 31 non-HD patients who underwent a first coronary stent implantation were studied. All patients received 100 or 200 mg of asprin and thienopiridine (either ticlopidine 200 mg or clopidogel 75 mg) daily. Platelet function was assessed 2-6 weeks (21 ± 8 days) after stent implantation by: (1) platelet maximal aggregation, using light transmittance aggregometry; (2) platelet aggregation threshold index, which was defined as putative concentration of agonist giving 50% maximum aggregation using whole-blood aggregometry; and (3) platelet activation markers (PAC-1 and CD62p), using whole blood flow cytometry...
July 2010: Cardiovascular Intervention and Therapeutics
Demarmels Biasiutti, Kremer Hovinga Strebel
For haemostatic and circulatory reasons pregnancy is associated with an about 6-fold relative increase of thrombotic risk which is further raised by additional risk factors, such as history of thrombosis or acquired and hereditary thrombophilia, respectively. Recently, the thrombophilias have been revealed as risk factors for severe preeclampsia, abruptio placentae, fetal growth retardation, abortion and still birth as well. Thus, there are several situations in which the question for the need of antithrombotic medication is raised in a pregnant woman, either for therapy of acute thromboembolism or for prophylaxis of thrombosis and obstetrical complications, respectively...
January 1, 2003: Therapeutische Umschau. Revue Thérapeutique
S Konstantinides, M Lankeit
Management of acute pulmonary embolism (PE) has advanced considerably in the past year, and progress is expected to continue in 2013. To help determine the optimal management strategy for normotensive patients with intermediate-risk PE, the Pulmonary Embolism Thrombolysis (PEITHO) study completed enrolment of 1006 patients with evidence of right ventricular dysfunction (by echocardiography or computed tomography) plus a positive troponin test. Patients have been randomised to thrombolytic treatment with tenecteplase versus placebo, and the effects on clinical end points (death or haemodynamic collapse) assessed at 7 and 30 days...
2013: Hämostaseologie
Yu-ze Li, Yu-jiao Sun, Bo Zhang, Da-ming Jiang, Yuan Gao, Hai-jie Yu, Guo-xian Qi
OBJECTIVE: To analyze the impact of body mass index (BMI) on the presentation, treatment, and clinical outcomes of patients with ST-segment elevated myocardial infarction (STEMI). METHODS: 1414 patients with STEMI who were admitted to the 20 hospitals in Liaoning region from May 2009 until May 2010 were enrolled. Patients were stratified according to the BMI levels as normal weight group (18.5 kg/m(2) ≤ BMI < 24.0 kg/m(2)) (n = 485), overweight (24.0 kg/m(2) ≤ BMI < 28...
December 2012: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
N Ghazali, J C Collyer, J V Tighe
This report presents the successful management of an advanced and refractory bisphosphonate-related osteonecrosis of the jaws (BRONJ) by hemimandibulectomy and an osteocutaneous fibula flap reconstruction in a patient with polycythaemia rubra vera, a rare haematological condition in which there is increased risk of thrombosis and haemorrhage. Union of the vascularized bone with the mandible depends on obtaining a BRONJ-free margin and rigid fixation of the bony ends. Magnetic resonance imaging can provide accurate delineation of necrotic bone and area of osteomyelitis...
January 2013: International Journal of Oral and Maxillofacial Surgery
Mohammad Asif, Arun Kumar
The antinociceptive activity of ethanolic extract of the plant bark of Dalbergia sissoo (Roxb.) was investigated using tail flick method on Wistar rats. Three different dose levels (300, 500, and 1000 mg/kg) in 0.5% carboxyl methyl cellulose (CMC) were administered by p.o. route. The antinociceptive activities of the all doses were compared with that of the standard drug asprin (300 mg/kg) administered by p.o. route and the results were found to be significant (P < 0.01). At the above doses, the extract exhibited significant and dose-dependent antinociceptive activity...
January 2011: Journal of Natural Science, Biology, and Medicine
Hiromu Sakurai
Copper (Cu) is essential for our daily life and it is found at approximately 110 mg in human adults with the body weight of 70 kg, in which this metal occurs at 46 mg in the bone and 26 mg in the muscle. Although Cu exists in the brain (approximately 5 mg/kg), liver (6 mg/kg), kidney (13 mg/kg), erythrocytes (90 mg/L), bile (6 mg/L) and serum (120 mg/L), its organ-specific distribution is not yet known. In metalloenzymes such as oxidoreductases, Cu is abundantly found and greatly contributes in life functions...
2012: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
Xin-Hua Wang, Dong-Hua Shao, Guo-Wei Liang, Ru Zhang, Qin Xin, Tao Zhang, Qing-Yun Cao
The study was purposed to investigate whether the cyclooxygenase inhibitors from some dietary vegetables can inhibit platelet aggregation function by the arachidonic acid (AA). The vegetable juice was mixed with platelet rich plasma (PRP), and asprin was used as positive control. The maximum ratio of platelet aggregation induced by AA was measured on the aggregometer; heme and cyclooxygenase-1 (COX(1)) or cyclooxygenase-2 (COX(2)) were added to test tubes containing COX reaction buffer, the mixture was vortex-mixed and exposed to aspirin or vegetable juice, followed by addition of AA and then hydrochloric acid (1 mol/L) was added to stop the COX reaction, followed by chemical reduction with stannous chloride solution...
October 2011: Zhongguo Shi Yan Xue Ye Xue za Zhi
Padmamalini Mahendradas, Rohit Shetty, Kavitha Avadhani, Cecil Ross, Anchal Gupta, Bhujang K Shetty
OBJECTIVE: To report a case of acute zonal occult outer retinopathy (AZOOR) caused by Polycythemia and increased levels of Factor VIIIC. DESIGN: Case Report - Interventional. METHODS: We present a 23 year old male with blurring of vision and loss of lower visual fields in both eyes. Ocular examination suggested the possibility of AZOOR that was confirmed with Fluorescein Angiogram, Visual fields and Electroretinogram. Laboratory work up revealed polycythemia with increased Factor VIIIC...
August 2010: Ocular Immunology and Inflammation
Sun-Hee Oh, Se-Min Park, Jong-Sook Park, An-Soo Jang, Yong-Mok Lee, Soo-Taek Uh, Young Hoon Kim, In-Seon Choi, Mi-Kyeong Kim, Byeong Lae Park, Hyoung-Doo Shin, Choon-Sik Park
PURPOSE: Peroxisome proliferator-activated receptors (PPARs) are transcriptional factors activated by ligands of the nuclear hormone receptor superfamily. The activation of PPARgamma regulates inflammation by downregulating the production of Th2 type cytokines and eosinophil function. In addition, a range of natural substances, including arachidonate pathway metabolites such as 15-hydroxyeicosatetranoic acid (15-HETE), strongly promote PPARG expression. Therefore, genetic variants of the PPARG gene may be associated with the development of aspirin-intolerant asthma (AIA)...
October 2009: Allergy, Asthma & Immunology Research
Kong-Sang Wan, Wei-Fong Wu
Eicosanoids belong to a diverse family of bioactive fatty acids that play important roles in regulating airway inflammation and reactivity. They are the key mediators of the pathobiology of asthma. Among the eicosanoids, lipoxins (LXs) were the first agents to be identified and recognized as potential anti-inflammatory endogenous lipid mediators. Lipoxins are biosynthesized in vivo at inflammation sites. They result mainly from the interaction between 5 and 15-lipoxygenases (LOs), which are distinct from leukotrienes (LTs) and prostaglandins (PGs) in structure and function...
November 2007: Acta Paediatrica Taiwanica, Taiwan Er Ke Yi Xue Hui za Zhi
Hong Liu, Shu-zheng Lü, Yun-dai Chen, Fei Yuan, Jing Li
OBJECTIVE: To analyze the reason of coronary artery aneurysmal dilations in patients after sirolimus-eluting stent implantation. METHODS: Late localized aneurysmal dilations post PCI were evidenced in 4 patients (age 69.5 +/- 3.5 years, 3 males) during follow-up (24.8 +/- 1.8 months). Nine stents were implanted into 7 diseased vessels: 5 Cypher select stents in LAD; 2 Firebird stents and 1 Pixel stent in LCX; 1 Cypher select stent in RCA. Clopidogrel (75 mg/d) was used for one year...
January 2007: Zhonghua Xin Xue Guan Bing za Zhi
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