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https://www.readbyqxmd.com/read/29220407/respiratory-resistance-and-reactance-in-adults-with-sickle-cell-anemia-correlation-with-functional-exercise-capacity-and-diagnostic-use
#1
Cirlene de Lima Marinho, Maria Christina Paixão Maioli, Jorge Luis Machado do Amaral, Agnaldo José Lopes, Pedro Lopes de Melo
BACKGROUND: The improvement in sickle cell anemia (SCA) care resulted in the emergence of a large population of adults living with this disease. The mechanisms of lung injury in this new population are largely unknown. The forced oscillation technique (FOT) represents the current state-of-the-art in the assessment of lung function. The present work uses the FOT to improve our knowledge about the respiratory abnormalities in SCA, evaluates the associations of FOT with the functional exercise capacity and investigates the early detection of respiratory abnormalities...
2017: PloS One
https://www.readbyqxmd.com/read/29220363/self-organization-in-a-diversity-induced-thermodynamics
#2
Alessandro Scirè, Valerio Annovazzi-Lodi
In this work we show how global self-organized patterns can come out of a disordered ensemble of point oscillators, as a result of a deterministic, and not of a random, cooperative process. The resulting system dynamics has many characteristics of classical thermodynamics. To this end, a modified Kuramoto model is introduced, by including Euclidean degrees of freedom and particle polarity. The standard deviation of the frequency distribution is the disorder parameter, diversity, acting as temperature, which is both a source of motion and of disorder...
2017: PloS One
https://www.readbyqxmd.com/read/29218453/energy-depletion-and-not-ros-formation-is-a-crucial-step-of-glucolipotoxicity-gltx-in-pancreatic-beta-cells
#3
Morgana Barroso Oquendo, Nikolas Layer, Rebecca Wagner, Peter Krippeit-Drews, Gisela Drews
We have shown previously that genetic or pharmacological deletion of KATP channels protect against beta cell dysfunction induced by reactive oxygen species (ROS). Since it is assumed that glucolipotoxicity (GLTx) causes ROS production, we aimed to evaluate whether suppression of KATP channel activity can also prevent beta cell damage evoked by GLTx. We used an in vitro model of GLTx and measured distinct parameters of stimulus-secretion coupling. GLTx gradually induced disturbances of Ca2+ oscillations over 3 days...
December 7, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29218303/dynamic-regimes-of-el-ni%C3%A3-o-southern-oscillation-and-influenza-pandemic-timing
#4
Olusegun Steven Ayodele Oluwole
El Niño southern oscillation (ENSO) dynamics has been shown to drive seasonal influenza dynamics. Severe seasonal influenza epidemics and the 2009-2010 pandemic were coincident with chaotic regime of ENSO dynamics. ENSO dynamics from 1876 to 2016 were characterized to determine if influenza pandemics are coupled to chaotic regimes. Time-varying spectra of southern oscillation index (SOI) and sea surface temperature (SST) were compared. SOI and SST were decomposed to components using the algorithm of noise-assisted multivariate empirical mode decomposition...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/29217687/role-of-the-axon-initial-segment-in-the-control-of-spontaneous-frequency-of-nigral-dopaminergic-neurons-in-vivo
#5
Rodrigo C Meza, Luciana López-Jury, Carmen C Canavier, Pablo Henny
The spontaneous tonic discharge activity of nigral dopamine neurons plays a fundamental role in dopaminergic signaling. To investigate the role of neuronal morphology and architecture with respect to spontaneous activity in this population, we visualized the 3D structure of the axon initial segment (AIS) along with the entire somatodendritic domain of adult male mouse dopaminergic neurons, previously recorded in vivo We observed a positive correlation of the firing rate with both proximity and size of the AIS...
December 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29217685/scale-free-amplitude-modulation-of-neuronal-oscillations-tracks-comprehension-of-accelerated-speech
#6
Ana Filipa Teixeira Borges, Anne-Lise Giraud, Huibert D Mansvelder, Klaus Linkenkaer-Hansen
Speech comprehension is preserved up to a three-fold acceleration but rapidly deteriorates at higher speeds. Current models posit that perceptual resilience to accelerated speech is limited by the brain's ability to parse speech into syllabic units using delta/theta oscillations. Here, we ask whether the involvement of neuronal oscillations in processing accelerated speech also relates to their scale-free amplitude modulation as indexed by the strength of long-range temporal correlations (LRTC). We recorded magnetoencephalography (MEG) while 24 human subjects (12 females) listened to radio news uttered at different comprehensible rates, at a mostly unintelligible rate, and at this same speed interleaved with silence gaps...
December 6, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29217404/high-density-eeg-characterization-of-brain-responses-to-auditory-rhythmic-stimuli-during-wakefulness-and-nrem-sleep
#7
Caroline Lustenberger, Yogi A Patel, Sankaraleengam Alagapan, Jessica M Page, Betsy Price, Michael R Boyle, Flavio Frohlich
Auditory rhythmic sensory stimulation modulates brain oscillations by increasing phase-locking to the temporal structure of the stimuli and by increasing the power of specific frequency bands, resulting in Auditory Steady State Responses (ASSR). The ASSR is altered in different diseases of the central nervous system such as schizophrenia. However, in order to use the ASSR as biological markers for disease states, it needs to be understood how different vigilance states and underlying brain activity affect the ASSR...
December 4, 2017: NeuroImage
https://www.readbyqxmd.com/read/29217191/tnf-%C3%AE-induces-expression-of-the-circadian-clock-gene-bmal1-via-dual-calcium-dependent-pathways-in-rheumatoid-synovial-cells
#8
Kohsuke Yoshida, Ayako Nakai, Kenta Kaneshiro, Naonori Hashimoto, Kohjin Suzuki, Koto Uchida, Teppei Hashimoto, Yoshiko Kawasaki, Koji Tateishi, Natsuko Nakagawa, Nao Shibanuma, Yoshitada Sakai, Akira Hashiramoto
Tumor necrosis factor (TNF)-α is responsible for expressions of several clock genes and affects joint symptoms of rheumatoid arthritis (RA) with diurnal fluctuation. We tried to determine the mechanism involved in over-expression of Bmal1, induced by TNF-α, in primary cultured rheumatoid synovial cells. Cells were incubated with intra-cellular Ca2+ chelator BAPTA-AM, calcineurin inhibitor FK506 and p300/CBP (CREB binding protein) inhibitor C646, respectively, or transfected with p300 and CBP small interfering RNA (siRNA) before stimulation with TNF-α...
December 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29216239/effects-of-early-afterdepolarizations-on-excitation-patterns-in-an-accurate-model-of-the-human-ventricles
#9
Enid Van Nieuwenhuyse, Gunnar Seemann, Alexander V Panfilov, Nele Vandersickel
Early Afterdepolarizations, EADs, are defined as the reversal of the action potential before completion of the repolarization phase, which can result in ectopic beats. However, the series of mechanisms of EADs leading to these ectopic beats and related cardiac arrhythmias are not well understood. Therefore, we aimed to investigate the influence of this single cell behavior on the whole heart level. For this study we used a modified version of the Ten Tusscher-Panfilov model of human ventricular cells (TP06) which we implemented in a 3D ventricle model including realistic fiber orientations...
2017: PloS One
https://www.readbyqxmd.com/read/29216187/a-thermostable-messenger-rna-based-vaccine-against-rabies
#10
Lothar Stitz, Annette Vogel, Margit Schnee, Daniel Voss, Susanne Rauch, Thorsten Mutzke, Thomas Ketterer, Thomas Kramps, Benjamin Petsch
Although effective rabies virus vaccines have been existing for decades, each year, rabies virus infections still cause around 50.000 fatalities worldwide. Most of these cases occur in developing countries, where these vaccines are not available. The reasons for this are the prohibitive high costs of cell culture or egg grown rabies virus vaccines and the lack of a functional cold chain in many regions in which rabies virus is endemic. Here, we describe the excellent temperature resistance of a non-replicating mRNA based rabies virus vaccine encoding the rabies virus glycoprotein (RABV-G)...
December 7, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29216180/the-ink4a-arf-locus-operates-as-a-regulator-of-the-circadian-clock-modulating-ras-activity
#11
Rukeia El-Athman, Nikolai N Genov, Jeannine Mazuch, Kaiyang Zhang, Yong Yu, Luise Fuhr, Mónica Abreu, Yin Li, Thomas Wallach, Achim Kramer, Clemens A Schmitt, Angela Relógio
The mammalian circadian clock and the cell cycle are two major biological oscillators whose coupling influences cell fate decisions. In the present study, we use a model-driven experimental approach to investigate the interplay between clock and cell cycle components and the dysregulatory effects of RAS on this coupled system. In particular, we focus on the Ink4a/Arf locus as one of the bridging clock-cell cycle elements. Upon perturbations by the rat sarcoma viral oncogene (RAS), differential effects on the circadian phenotype were observed in wild-type and Ink4a/Arf knock-out mouse embryonic fibroblasts (MEFs), which could be reproduced by our modelling simulations and correlated with opposing cell cycle fate decisions...
December 2017: PLoS Biology
https://www.readbyqxmd.com/read/29216145/tailoring-axial-intensity-of-laser-beams-with-a-heart-shaped-hole
#12
Yulong Wang, Lijuan Xie, Jiasheng Ye, Wenfeng Sun, Xinke Wang, Shengfei Feng, Peng Han, Qiang Kan, Yan Zhang
We demonstrated a simple heart-shaped hole to tailor the axial intensity of a collimated laser beam. This hole is transformed from a soft-boundary one, which avoids the difficulty in fabricating the soft-boundary mask designed by the apodization method, as well as the interference problem caused by the pixel structure of the spatial light modulator. When a collimated light passes through this hole, its axial intensity oscillates less than 11% within a certain distance, while the fluctuation after the circular aperture is up to 200%...
December 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/29216137/generation-of-70-fs-pulses-at-2-86%C3%A2-%C3%A2-%C3%AE-m-from-a-mid-infrared-fiber-laser
#13
R I Woodward, D D Hudson, A Fuerbach, S D Jackson
We propose and demonstrate a simple route to few-optical-cycle pulse generation from a mid-infrared fiber laser through nonlinear compression of pulses from a holmium-doped fiber oscillator using a short length of chalcogenide fiber and a grating pair. Pulses from the oscillator with 265-fs duration at 2.86 μm are spectrally broadened through self-phase modulation in step-index As2S3 fiber to 141-nm bandwidth and then re-compressed to 70 fs (7.3 optical cycles). These are the shortest pulses from a mid-infrared fiber system to date, and we note that our system is compact, robust, and uses only commercially available components...
December 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/29216130/third-order-nonlinearity-opo-schmidt-mode-decomposition-and-tripartite-entanglement
#14
C González-Arciniegas, Nicolas Treps, P Nussenzveig
We investigate quantum properties of light in optical parametric oscillators (OPOs) based on four-wave mixing gain in media with third-order nonlinearities. In spite of other competing χ(3) effects such as phase modulation, bipartite and tripartite entanglement is predicted above threshold. These findings are relevant for recent implementations of complementary metal-oxide-semiconductor (CMOS)-compatible on-chip OPOs.
December 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/29216122/delay-line-coherent-pulse-stacking
#15
Henrik Tünnermann, Akira Shirakawa
Ultrafast fiber amplifiers are usually limited in terms of pulse energy and peak power due to fiber damage and nonlinearities. On the other hand, fiber amplifiers are very energy efficient. To take advantage of this efficiency, but still scale the pulse energy, coherent combining and pulse stacking have become the method of choice. Here we show how to directly and symmetrically stack up the pulses from an oscillator chain, using delay lines and phase preshaping of a 48 MHz, 1.5 μm master oscillator. This method avoids the need for high-power low-loss dumpers as in passive stack and dump cavities and, compared to divided pulse amplification (DPA), it eliminates the need for splitting pulses and pulse picking and, thus, optimally utilizes the available seed power...
December 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/29216115/efficient-wavelength-conversion-with-low-operation-power-in-a-ta2o5-based-micro-ring-resonator
#16
Chung-Lun Wu, Jen-Yang Huang, Ding-Hsin Ou, Ting-Wei Liao, Yi-Jen Chiu, Min-Hsiung Shih, Yuan-Yao Lin, Ann-Kuo Chu, Chao-Kuei Lee
The Ta2O5-based micro-ring resonator with an unloaded quality factor of 182,000 has been demonstrated to realize efficient nonlinear wavelength generation. The propagation loss of the resonator is 0.5  cm-1, and the buildup factor of the ring resonator is estimated to be ∼50. With a high buildup factor of the ring structure, the four-wave-mixing (FWM) conversion efficiency of -30  dB is achieved in the resonator with a pump power of 6 mW. Based on power-dependent FWM results, the nonlinear refractive index of Ta2O5 is estimated to be 1...
December 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/29216069/high-energy-stable-single-frequency-ho-yag-ceramic-amplifier-system
#17
Yixuan Zhang, Chunqing Gao, Qing Wang, QuanXin Na, Mingwei Gao, Meng Zhang, Qing Ye, YuJia Wang, Jian Zhang
We demonstrate a 2090 nm single-frequency, high-energy, Q-switched Ho:YAG ceramic master oscillator and power amplifier system that contains two-stage amplifiers. The maximum single-frequency pulse energy is 55.64 mJ at a pulse repetition frequency of 200 Hz. The half-width of the pulse spectrum is measured to be 3.96 MHz by a heterodyne technique. To the best of our knowledge, 55.64 mJ is the highest single-frequency output energy obtained from the Ho:YAG laser.
December 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29215846/-possibilities-of-correction-rheological-blood-svoytv-at-chipped-and-cut-wounds-of-the-breast
#18
V V Masljakov, O A Suhanova, V G Barsukov, K G Kurkin, S A Suhanov
The purpose: research objective: to study influence of electromagnetic oscillations of millimetric range on rheological properties of blood at patients with chipped and cut wounds of a breast for the purpose of their correction. Methods. For the solution of a research objective we have carried out studying of changes of rheological properties of blood at the 22nd patient with the getting chipped and cut wounds of a breast without internal injury during the next postoperative period. All patient has executed primary surgical processing and drainage of a pleural cavity...
April 2017: Patologicheskaia Fiziologiia i èksperimental'naia Terapiia
https://www.readbyqxmd.com/read/29215792/deuterated-molecular-ruby-with-record-luminescence-quantum-yield
#19
Cui Wang, Sven Otto, Matthhias Dorn, Elisabeth Kreidt, Jakob Lebon, Laura Sran, Patrick Di Martino-Fumo, Markus Gerhards, Ute Resch-Genger, Michael Seitz, Katja Heinze
The recently reported luminescent chromium(III) complex [Cr(ddpd)2]3+ shows exceptionally strong near-IR emission in water under ambient conditions (QY 11 %) with a microsecond lifetime. In the absence of energy acceptors such as dioxygen, the remaining decay pathways are energy transfer to high energy solvent and ligand oscillators, namely OH and CH stretching vibrations. Selective deuteration of the solvents and the ddpd ligands probes the efficiency of these oscillators in the excited state deactivation...
December 7, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29215064/self-adaptive-bioinspired-hummingbird-wing-stimulated-triboelectric-nanogenerators
#20
Abdelsalam Ahmed, Islam Hassan, Peiyi Song, Mohamed Gamaleldin, Ali Radhi, Nishtha Panwar, Swee Chuan Tjin, Ahmed Y Desoky, David Sinton, Ken-Tye Yong, Jean Zu
Bio-inspired technologies have remarkable potential for energy harvesting from clean and sustainable energy sources. Inspired by the hummingbird-wing structure, we propose a shape-adaptive, lightweight triboelectric nanogenerator (TENG) designed to exploit the unique flutter mechanics of the hummingbird for small-scale wind energy harvesting. The flutter is confined between two surfaces for contact electrification upon oscillation. We investigate the flutter mechanics on multiple contact surfaces with several free-standing and lightweight electrification designs...
December 7, 2017: Scientific Reports
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