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Cognitive remediation

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https://www.readbyqxmd.com/read/29910120/does-social-cognition-training-augment-response-to-computer-assisted-cognitive-remediation-for-schizophrenia
#1
Jean-Pierre Lindenmayer, Anzalee Khan, Susan R McGurk, Mila Kirstie C Kulsa, Isidora Ljuri, Veronica Ozog, Samantha Fregenti, Gianna Capodilupo, Kiara Buccellato, Amod Thanju, Abraham Goldring, Mohan Parak, Benedicto Parker
OBJECTIVES: Cognitive remediation therapy (CRT) has shown significant improvement in cognition in schizophrenia. However, effect sizes of CRT have been reported to be modest raising the issue how to augment the effects of CRT on neurocognition and social cognition. Our aim was to examine whether the addition of computerized social cognition training would enhance the effects on neurocognition and social cognition as compared to CRT alone. METHODS: This is a 12-week, parallel group trial of 131 in- and out-patients with schizophrenia randomized to CRT (COGPACK or Brain Fitness) with computerized social cognition training (MRIGE), or CRT alone for 36 sessions...
June 14, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29907105/implementing-cognitive-remediation-and-social-cognitive-interaction-training-into-standard-psychosis-care
#2
Frances Dark, Meredith Harris, Victoria Gore-Jones, Ellie Newman, Harvey Whiteford
BACKGROUND: To evaluate the planned implementation of group based Cognitive Remediation therapy (CR) and Social Cognitive Interaction Training (SCIT) into routine psychosis care in a mental health service in Australia. METHOD: The study was conducted over 3 years in a mental health service in a metropolitan city in Australia. Participants were 22 program facilitators and 128 patients attending the programs. Implementation outcomes were assessed using administrative data, staff surveys and program audits...
June 15, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29892074/impaired-hippocampal-representation-of-place-in-the-fmr1-knockout-mouse-model-of-fragile-x-syndrome
#3
Tara Arbab, Cyriel M A Pennartz, Francesco P Battaglia
Fragile X syndrome (FXS) is an X-chromosome linked intellectual disability and the most common known inherited single gene cause of autism spectrum disorder (ASD). Building upon demonstrated deficits in neuronal plasticity and spatial memory in FXS, we investigated how spatial information processing is affected in vivo in an FXS mouse model (Fmr1-KO). Healthy hippocampal neurons (so-called place cells) exhibit place-related activity during spatial exploration, and their firing fields tend to remain stable over time...
June 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29885424/common-social-cognitive-impairments-do-not-mean-common-causes-a-commentary-on-cotter-et-al-2018
#4
David Dodell-Feder, Laura T Germine
Many clinical conditions, ranging from psychiatric to neurodegenerative illnesses, are associated with impairment in the processes by which we perceive, interpret, and respond to social information; a suite of abilities known as social cognition. Through a systematic review of meta-analyses, Cotter et al. (2018) present a compelling view of social cognitive deficits as a core phenotype of many clinical conditions. However, we caution against one potential interpretation of their findings, namely, that similar social cognitive outcomes are produced by similar causes...
June 6, 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29883874/radon-and-lung-cancer-what-does-the-public-really-know
#5
REVIEW
Nancy Vogeltanz-Holm, Gary G Schwartz
Radon causes approximately 21,000 deaths annually from lung cancer, making it the second most important cause of lung cancer after smoking. However, the extent of public knowledge about radon is unclear. We systematically reviewed the epidemiologic literature in order to assay the public's understanding about radon and specifically, whether radon is known to cause lung cancer. Radon knowledge has most often been gauged via telephone and in-person responses to the question, "Have you heard about radon?" Our review of 20 such studies reveals that although many individuals have "heard about" radon, many segments of the population, particularly individuals younger than thirty and those with less education, do not know what radon is...
June 5, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29883859/interventions-for-the-treatment-of-theory-of-mind-deficits-in-schizophrenia-systematic-literature-review
#6
REVIEW
Edit Vass, Zita Fekete, Viktória Simon, Lajos Simon
Theory of Mind (ToM) plays a central role in regulating social interactions and its impairment is consistently reported in schizophrenia. Regarding schizophrenia, ToM is usually discussed as a sub-domain of social cognition. Since social cognitive deficits have drawn the attention of researchers, a variety of novel treatment techniques and approaches targeting social cognitive deficits have been developed. Encouraging results have repeatedly been reported on the modifiability of social cognitive impairment through these techniques...
May 22, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29881705/thymoquinone-recovers-learning-function-in-a-rat-model-of-alzheimer-s-disease
#7
Parvin Poorgholam, Parichehreh Yaghmaei, Zahra Hajebrahimi
Objective: Alzheimer's disease is a neurodegenerative disorder characterized by accumulation of amyloid beta in the hippocampus. In recent decades, herbal medicine has been widely used to treat many neurodegenerative disorders,as in comparison to conventional drugs, herbal remedies exert minimal side effects. Here, the effects of thymoquinone, as the main active component of Nigella sativa , on passive avoidance memory in rat model of Alzheimer's disease, were evaluated. Materials and Methods: Hippocampal injection of amyloid beta (Aβ) was used to induce Alzheimer's disease in male Wistar rats, followed by intra peritoneal administrations of 5 and 10 mg/kg thymoquinone on a daily basis for 4 weeks...
May 2018: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/29879231/the-association-of-fatigue-pain-depression-and-anxiety-with-work-and-activity-impairment-in-immune-mediated-inflammatory-diseases
#8
Murray W Enns, Charles N Bernstein, Kristine Kroeker, Lesley Graff, John R Walker, Lisa M Lix, Carol A Hitchon, Renée El-Gabalawy, John D Fisk, Ruth Ann Marrie
Impairment in work function is a frequent outcome in patients with chronic conditions such as immune-mediated inflammatory diseases (IMID), depression and anxiety disorders. The personal and economic costs of work impairment in these disorders are immense. Symptoms of pain, fatigue, depression and anxiety are potentially remediable forms of distress that may contribute to work impairment in chronic health conditions such as IMID. The present study evaluated the association between pain [Medical Outcomes Study Pain Effects Scale], fatigue [Daily Fatigue Impact Scale], depression and anxiety [Hospital Anxiety and Depression Scale] and work impairment [Work Productivity and Activity Impairment Scale] in four patient populations: multiple sclerosis (n = 255), inflammatory bowel disease (n = 248, rheumatoid arthritis (n = 154) and a depression and anxiety group (n = 307), using quantile regression, controlling for the effects of sociodemographic factors, physical disability, and cognitive deficits...
2018: PloS One
https://www.readbyqxmd.com/read/29804303/computerised-working-memory-based-cognitive-remediation-therapy-does-not-affect-reading-the-mind-in-the-eyes-test-performance-or-neural-activity-during-a-facial-emotion-recognition-test-in-psychosis
#9
David Mothersill, Rachael Dillon, April Hargreaves, Marco Castorina, Emilia Furey, Andrew J Fagan, James F Meaney, Brian Fitzmaurice, Brian Hallahan, Colm McDonald, Til Wykes, Aiden Corvin, Ian H Robertson, Gary Donohoe
Working memory based cognitive remediation therapy (CT) for psychosis has recently been associated with broad improvements in performance on untrained tasks measuring working memory, episodic memory and IQ, and changes in associated brain regions. However, it is unclear if these improvements transfer to the domain of social cognition and neural activity related to performance on social cognitive tasks. We examined performance on the Reading the Mind in the Eyes test (Eyes test) in a large sample of participants with psychosis who underwent working memory based CT (N = 43) compared to a Control Group of participants with psychosis (N = 35)...
May 27, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29781173/discourse-and-cognition-in-speakers-with-acquired-brain-injury-abi-a-systematic-review
#10
REVIEW
Elizabeth Hill, Mary Claessen, Anne Whitworth, Mark Boyes, Roslyn Ward
BACKGROUND: Cognitive impairment, particularly of executive functioning, has been implicated in deficits in spoken discourse production following acquired brain injury (ABI). However, due to variation in the methodologies and heterogeneity of findings across studies, the nature and extent of this association is not well understood. AIMS: This review aims to synthesize the literature investigating associations between cognitive deficits and discourse impairment after ABI...
May 20, 2018: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29773015/caffeine-a-potential-protective-agent-against-cognitive-decline-in-alzheimer-s-disease
#11
Azhar Hussain, Elsa S Tabrez, Volodymyr Mavrych, Olena Bolgova, Jagannadha Rao Peela
Over the past few decades, caffeine has been well recognized as a stimulant whose effects can be detected particularly in the central nervous system. A stimulating effect of caffeine has been found useful in treating patients with many neurological disorders, including Alzheimer's disease (AD). AD is reported to be a rapidly increasing public health problem with lack of a remedial treatment. However, the assumed protective effects of caffeine against AD are of huge interest. This study substantiates caffeine's role as a potential prevention agent against AD through several epidemiological studies...
2018: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/29765502/the-phenolic-components-of-gastrodia-elata-improve-prognosis-in-rats-after-cerebral-ischemia-reperfusion-by-enhancing-the-endogenous-antioxidant-mechanisms
#12
Anhuan Shi, Jianming Xiang, Fangyan He, Yanping Zhu, Gongbei Zhu, Yuhan Lin, Ningna Zhou
Pharmacological or spontaneous thrombolysis in ischemic stroke triggers an outbreak of reactive oxygen species and results in neuron death. Nrf2-mediated antioxidation in cells has been proved as a pivotal target for neuroprotection. This research reports that phenolic components of Gastrodia elata Blume (PCGE), a traditional Chinese medicine, can alleviate the pathological lesions in the penumbra and hippocampus by increasing the survival of neurons and astrocytes and improve neurofunction and cognition after reperfusion in a rat model of middle cerebral artery occlusion...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29763648/autism-spectrum-disorder-classification-diagnosis-and-therapy
#13
REVIEW
Samata R Sharma, Xenia Gonda, Frank I Tarazi
Autism Spectrum Disorder (ASD) refers to a group of neurodevelopmental disorders including autism, Asperger's syndrome (AS) and pervasive developmental disorder-not otherwise specified (PDD-NOS). The new diagnostic criteria of ASD focuses on two core domains: social communication impairment and restricted interests/repetitive behaviors. The prevalence of ASD has been steadily increasing over the past two decades, with current estimates reaching up to 1 in 36 children. Hereditary factors, parental history of psychiatric disorders, pre-term births, and fetal exposure to psychotropic drugs or insecticides have all been linked to higher risk of ASD...
May 12, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29759684/how-aging-impacts-the-encoding-of-binaural-cues-and-the-perception-of-auditory-space
#14
REVIEW
Ann Clock Eddins, Erol J Ozmeral, David A Eddins
Over the years, the effect of aging on auditory function has been investigated in animal models and humans in an effort to characterize age-related changes in both perception and physiology. Here, we review how aging may impact neural encoding and processing of binaural and spatial cues in human listeners with a focus on recent work by the authors as well as others. Age-related declines in monaural temporal processing, as estimated from measures of gap detection and temporal fine structure discrimination, have been associated with poorer performance on binaural tasks that require precise temporal processing...
May 5, 2018: Hearing Research
https://www.readbyqxmd.com/read/29751937/beyond-thiamine-treatment-for-cognitive-impairment-in-korsakoff-s-syndrome
#15
REVIEW
Justin M Johnson, Valerie Fox
BACKGROUND: Wernicke's encephalopathy is a condition whose treatment many consultation-liaison psychiatrists know quite well. Less clear, however, is the treatment of its dementia disorder descendent, the Korsakoff's syndrome (KS). OBJECTIVE: This article seeks to review treatment options and provide recommendations for consultation-liaison psychiatrists treating cognitive impairment in KS. METHODS: In this nonsystematic review, we reviewed PubMed, CINAHL Plus, and Google Scholar for published reports and studies regarding treatment of KS...
March 27, 2018: Psychosomatics
https://www.readbyqxmd.com/read/29738943/feasibility-of-group-cognitive-remediation-therapy-in-an-adult-eating-disorder-day-program-in-new-zealand
#16
Marion E Roberts
OBJECTIVE: To explore the feasibility of integrating group Cognitive Remediation Therapy (gCRT) into an eating disorder day program in Auckland, New Zealand. METHOD: A consecutive series of 28 patients took part over an 8-month period in the context of a service audit. Main outcome measures were the Detail and Flexibility Questionnaire (DFlex) and qualitative feedback from patients. RESULTS: Significant shifts in self-report inefficient cognitive style were observed pre/post gCRT with large effect sizes (Cohen's dav ) for both cognitive rigidity and attention to detail outcomes...
May 2, 2018: Eating Behaviors
https://www.readbyqxmd.com/read/29734950/prevalence-and-determinants-of-cognitive-impairment-in-the-euthymic-phase-of-bipolar-disorders-results-from-the-face-bd-cohort
#17
Paul Roux, Bruno Etain, Anne-Sophie Cannavo, Valérie Aubin, Bruno Aouizerate, Jean-Michel Azorin, Frank Bellivier, Raoul Belzeaux, Thierry Bougerol, Iréna Cussac, Philippe Courtet, Jean-Pierre Kahn, Marion Leboyer, Katia M'Bailara, Marion Perrin Payet, Emilie Olié, Chantal Henry, Christine Passerieux
BACKGROUND: Cognitive deficits are a well-established feature of bipolar disorders (BD), even during periods of euthymia, but risk factors associated with cognitive deficits in euthymic BD are still poorly understood. We aimed to validate classification criteria for the identification of clinically significant cognitive impairment, based on psychometric properties, to estimate the prevalence of neuropsychological deficits in euthymic BD, and identify risk factors for cognitive deficits using a multivariate approach...
May 8, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29729278/restoration-of-sensory-input-may-improve-cognitive-and-neural-function
#18
Hanin Karawani, Kimberly Jenkins, Samira Anderson
Age-related hearing loss is one of the most prevalent health conditions among the elderly. Hearing loss may lead to social isolation, depression, and cognitive decline in older adults. The mechanistic basis for the association between hearing loss and decreased cognitive function remains unknown as does the potential for improving cognition through hearing rehabilitation. To that end, we asked whether the restoration of sensory input through the use of hearing aids would improve cognitive and auditory neural function...
May 2, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29728871/psychological-interventions-in-psychosis-in-children-and-adolescents-a-systematic-review
#19
REVIEW
Nefeli Anagnostopoulou, Marinos Kyriakopoulos, Anca Alba
BACKGROUND: Early onset psychosis (EOP), referring to psychosis with onset before the age of 18 years, is a more severe form of psychosis associated with worse prognosis. While medication is the treatment of choice, psychological interventions are also considered to have an important role in the management of symptoms and disability associated with this condition. The present review aimed to explore the effectiveness of such interventions. METHOD: An electronic search was conducted on the Embase, Medline, and PsychInfo databases for papers of randomized controlled trials (RCTs) referring to psychological interventions in EOP...
May 4, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29726749/international-variation-in-programmes-for-assessment-of-children-s-neurodevelopment-in-the-community-understanding-disparate-approaches-to-evaluation-of-motor-social-emotional-behavioural-and-cognitive-function
#20
Philip Wilson, Rachael Wood, Kirsten Lykke, Anette Hauskov Graungaard, Ruth Kirk Ertmann, Merethe Kirstine Andersen, Ole Rikard Haavet, Per Lagerløv, Eirik Abildsnes, Mina P Dahli, Marjukka Mäkelä, Aleksi Varinen, Merja Hietanen
BACKGROUND: Few areas of medicine demonstrate such international divergence as child development screening and surveillance. Many countries have nationally mandated surveillance policies, but the content of programmes and mechanisms for delivery vary enormously. The cost of programmes is substantial but no economic evaluations have been carried out. We have critically examined the history, underlying philosophy, content and delivery of programmes for child development assessment in five countries with comprehensive publicly funded health services (Denmark, Finland, Norway, Scotland and Sweden)...
May 1, 2018: Scandinavian Journal of Public Health
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