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Cognitive remediation

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https://www.readbyqxmd.com/read/29447133/computerised-training-improves-cognitive-performance-in-chronic-pain-a-participant-blinded-randomised-active-controlled-trial-with-remote-supervision
#1
Katharine S Baker, Nellie Georgiou-Karistianis, Amit Lampit, Michael Valenzuela, Stephen J Gibson, Melita J Giummarra
Chronic pain is associated with reduced efficiency of cognitive performance, and few studies have investigated methods of remediation. We trialled a computerised cognitive training protocol to determine whether it could attenuate cognitive difficulties in a chronic pain sample. Thirty-nine adults with chronic pain (mean age = 43.3, 61.5% females) were randomised to an 8-week online course (3 sessions/week from home) of game-like cognitive training exercises, or an active control involving watching documentary videos...
January 11, 2018: Pain
https://www.readbyqxmd.com/read/29422299/a-randomized-controlled-trial-examining-a-cognitive-behavioral-therapy-intervention-enhanced-with-cognitive-remediation-to-improve-work-and-neurocognition-outcomes-among-persons-with-schizophrenia-spectrum-disorders
#2
Marina Kukla, Morris D Bell, Paul H Lysaker
This single blind, three-armed randomized controlled trial compared cognitive behavioral therapy (CBT) enhanced with cognitive remediation (CBT+CR) to CBT alone and an active control condition on work and neurocognition outcomes for persons with schizophrenia spectrum disorders. Seventy-five adult outpatients with schizophrenia or schizoaffective disorder were randomized to three study conditions (N=25 per group). The CBT intervention was the Indianapolis Vocational Intervention program (IVIP), consisting of weekly group and individual sessions focused on work-related content...
February 5, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29398932/neuropsychological-assessment-in-autism-spectrum-disorder-and-related-conditions
#3
Georg Peter Zwick
Neuropsychological assessment provides a profound analysis of cognitive functioning in people with autism spectrum disorder (ASD). Individuals on the autistic spectrum often show a high level of anxiety and are frequently affected by comorbidities that influence their quality of life. Yet, they also have cognitive strengths that should be identified in order to develop effective support strategies. This article presents an overview of five cognitive areas that are essential for neuropsychological evaluation (ie, intelligence, attention, executive function, social cognition, and praxis) and explores the underlying causes of behavioral problems in persons with ASD...
December 2017: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/29397662/cognitive-deficits-in-schizophrenia-understanding-the-biological-correlates-and-remediation-strategies
#4
REVIEW
Adarsh Tripathi, Sujita Kumar Kar, Rashmi Shukla
Cognitive deficits are one of the core symptoms of schizophrenia that evolve during the course of schizophrenia, after being originated even before the onset of illness. Existing pharmacological and biological treatment modalities fall short to meet the needs to improve the cognitive symptoms; hence, various cognitive remediation strategies have been adopted to address these deficits. Research evidences suggest that cognitive remediation measures improve the functioning, limit disability bettering the quality of life...
February 28, 2018: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29379114/comparison-of-focused-cognitive-training-and-portable-brain-games-on-functional-outcomes-for-vocational-rehabilitation-participants
#5
Morris D Bell, Holly Laws, Brian Pittman, Jason K Johannesen
Cognitive remediation performed in a cognitive laboratory was compared with a sham control using portable brain games to study effects on vocational, neurocognitive, and functional outcomes for participants with psychotic disorders in vocational rehabilitation (VR). Seventy-seven participants (61% schizophrenia, 39% other psychosis) in transitional (45.5%) or supported employment (54.5%) were randomly assigned to 6 months of portable cognitive-games (CG) or cognitive remediation (CR) plus a weekly goal-setting group, and evaluated during training, post-training and at 12 months...
January 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29369487/an-update-on-adjunctive-treatment-options-for-bipolar-disorder
#6
REVIEW
Olivia M Dean, Emma Gliddon, Tamsyn E Van Rheenen, Francesco Giorlando, Sandra K Davidson, Manreena Kaur, Trung T Ngo, Lana J Williams
OBJECTIVES: Bipolar disorder is a complex illness often requiring combinations of therapies to successfully treat symptoms. In recent years, there have been significant advancements in a number of therapies for bipolar disorder. It is therefore timely to provide an overview of current adjunctive therapeutic options to help treating clinicians to inform their patients and work towards optimal outcomes. METHODS: Publications were identified from PubMed searches on bipolar disorder and pharmacotherapy, nutraceuticals, hormone therapy, psychoeducation, interpersonal and social rhythm therapy, cognitive remediation, mindfulness, e-Health and brain stimulation techniques...
January 25, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29360609/a-model-based-quantification-of-action-control-deficits-in-parkinson-s-disease
#7
Mathieu Servant, Nelleke van Wouwe, Scott A Wylie, Gordon D Logan
Basal ganglia dysfunction in Parkinson's disease (PD) is thought to generate deficits in action control, but the characterization of these deficits have been qualitative rather than quantitative. Patients with PD typically show prolonged response times on tasks that instantiate a conflict between goal-directed processing and automatic response tendencies. In the Simon task, for example, the irrelevant location of the stimulus automatically activates a corresponding lateralized response, generating a potential conflict with goal-directed choices...
January 19, 2018: Neuropsychologia
https://www.readbyqxmd.com/read/29352823/neurocognitive-and-self-efficacy-benefits-of-cognitive-remediation-in-schizophrenia-a-randomized-controlled-trial
#8
Shayden D Bryce, Susan L Rossell, Stuart J Lee, Richard J Lawrence, Eric J Tan, Sean P Carruthers, Jennie L Ponsford
OBJECTIVES: The aim of this study was to evaluate the impact of computer-assisted "drill-and-strategy" cognitive remediation (CR) for community-dwelling individuals with schizophrenia on cognition, everyday self-efficacy, and independent living skills. METHODS: Fifty-six people with schizophrenia or schizoaffective disorder were randomized into CR or computer game (CG) playing (control), and offered twenty 1-hr individual sessions in a group setting over 10 weeks...
January 21, 2018: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29351056/remediation-of-radiation-induced-cognitive-dysfunction-through-oral-administration-of-the-neuroprotective-compound-nsi-189
#9
Barrett Allen, Munjal M Acharya, Celine Lu, Erich Giedzinski, Nicole Chmielewski, David Quach, Mike Hefferan, Karl K Johe, Charles L Limoli
Clinical management of primary and secondary central nervous system (CNS) malignancies frequently includes radiotherapy to forestall tumor growth and recurrence after surgical resection. While cranial radiotherapy remains beneficial, adult and pediatric brain tumor survivors suffer from a wide range of debilitating and progressive cognitive deficits. Although this has been recognized as a significant problem for decades, there remains no clinical recourse for the unintended neurocognitive sequelae associated with these types of cancer treatments...
January 19, 2018: Radiation Research
https://www.readbyqxmd.com/read/29346658/potential-for-diet-to-prevent-and-remediate-cognitive-deficits-in-neurological-disorders
#10
Heather M Francis, Richard J Stevenson
The pathophysiology of many neurological disorders involves oxidative stress, neuroinflammation, and mitochondrial dysfunction. There is now substantial evidence that diet can decrease these forms of pathophysiology, and an emerging body of literature relatedly suggests that diet can also prevent or even remediate the cognitive deficits observed in neurological disorders that exhibit such pathology (eg, Alzheimer's disease, multiple sclerosis, age-related cognitive decline, epilepsy). The current review summarizes the emerging evidence in relation to whole diets prominent in the scientific literature-ketogenic, caloric restriction, high polyphenol, and Mediterranean diets-and provides a discussion of the possible underlying neurophysiological mechanisms...
January 15, 2018: Nutrition Reviews
https://www.readbyqxmd.com/read/29345581/premorbid-and-illness-related-social-difficulties-in-eating-disorders-an-overview-of-the-literature-and-treatment-developments
#11
Valentina Cardi, Kate Tchanturia, Janet Treasure
Social difficulties in eating disorders can manifest as predisposing traits and premorbid difficulties, and/or as consequences of the illness. Objective The aim of this paper is to briefly review the evidence for social problems in people with eating disorders and to consider the literature on treatments that target these features. Method A narrative review of the literature was conducted. Results People with eating disorders often manifest traits, such as shyness, increased tendency to submissiveness and social comparison, and problems with peer relationships before illness onset...
January 17, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29341129/diagnosing-crime-and-diagnosing-disease-ii-visual-pattern-perception-and-diagnostic-accuracy
#12
Saty Satya-Murti, Joseph J Lockhart
Previously, we reviewed how general cognitive processes might be susceptible to bias across both forensic and clinical fields, and how interdisciplinary comparisons could reduce error. We discuss several examples of clinical tasks which are heavily dependent on visual processing, comparing them to eyewitness identification (EI). We review the "constructive" nature of visual processing, and how contextual factors influence both medical experts and witnesses in decision making and recall. Overall, studies suggest common cognitive factors uniting these visual tasks, in both their strengths and shortcomings...
January 16, 2018: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/29337277/compensatory-dopaminergic-cholinergic-interactions-in-conflict-processing-evidence-from-patients-with-parkinson-s-disease
#13
REVIEW
Kamin Kim, Nicolaas I Bohnen, Martijn L T M Müller, Cindy Lustig
Executive functions are complex both in the cognitive operations involved and in the neural structures and functions that support those operations. This complexity makes executive function highly vulnerable to the detrimental effects of aging, brain injury, and disease, but may also open paths to compensation. Neural compensation is often used to explain findings of additional or altered patterns of brain activations by older adults or patient populations compared to young adults or healthy controls, especially when associated with relatively preserved performance...
January 11, 2018: NeuroImage
https://www.readbyqxmd.com/read/29306052/celecoxib-prevents-cognitive-impairment-and-neuroinflammation-in-soluble-amyloid-%C3%AE-treated-rats
#14
Emanuela Mhillaj, Maria Grazia Morgese, Paolo Tucci, Anna Furiano, Livio Luongo, Maria Bove, Sabatino Maione, Vincenzo Cuomo, Stefania Schiavone, Luigia Trabace
Recent findings suggest that soluble forms of amyloid-β (sAß) peptide contribute to synaptic and cognitive dysfunctions in early stages of Alzheimer's disease (AD). On the other hand, neuroinflammation and cyclooxygenase-2 (COX-2) enzyme have gained increased interest as key factors involved early in AD, although the signaling pathways and pathophysiologic mechanisms underlying a link between sAß-induced neurotoxicity and inflammation are still unclear. Here, we investigated the effects of selective COX-2 enzyme inhibition on neuropathological alterations induced by sAβ administration in rats...
January 3, 2018: Neuroscience
https://www.readbyqxmd.com/read/29298678/the-brainfit-study-efficacy-of-cognitive-training-and-exergaming-in-pediatric-cancer-survivors-a-randomized-controlled-trial
#15
Valentin Benzing, Noëmi Eggenberger, Janine Spitzhüttl, Valerie Siegwart, Manuela Pastore-Wapp, Claus Kiefer, Nedelina Slavova, Michael Grotzer, Theda Heinks, Mirko Schmidt, Achim Conzelmann, Maja Steinlin, Regula Everts, Kurt Leibundgut
BACKGROUND: Cancer survival comes at a price: pediatric cancer survivors bear a high risk for a wide range of cognitive difficulties. Therefore, interventions targeting these difficulties are required. The aim of the present clinical trial is to extend empirical evidence about efficacy of cognitive and physical training in pediatric cancer survivors. It is hypothesized that early cognitive and physical interventions affect the remediation of pediatric cancer survivors in terms of improved executive functions (primary outcome)...
January 3, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29286586/cognitive-enhancement-therapy-for-adult-autism-spectrum-disorder-results-of-an-18-month-randomized-clinical-trial
#16
Shaun M Eack, Susan S Hogarty, Deborah P Greenwald, Maralee Y Litschge, Shannondora A Porton, Carla A Mazefsky, Nancy J Minshew
Cognitive remediation is a promising approach to treating core cognitive deficits in adults with autism, but rigorously controlled trials of comprehensive interventions that target both social and non-social cognition over a sufficient period of time to impact functioning are lacking. This study examined the efficacy of cognitive enhancement therapy (CET) for improving core cognitive and employment outcomes in adult autism. Verbal adult outpatients with autism spectrum disorder (N = 54) were randomized to an 18-month, single-blind trial of CET, a cognitive remediation approach that integrates computer-based neurocognitive training with group-based training in social cognition, or an active enriched supportive therapy (EST) comparison focused on psychoeducation and condition management...
December 29, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29285052/suppression-of-alzheimer-s-disease-related-phenotypes-by-the-heat-shock-protein-70-inducer-geranylgeranylacetone-in-app-ps1-transgenic-mice-via-the-erk-p38-mapk-signaling-pathway
#17
Yuan Sun, Jiang-Rong Zhang, Shuyan Chen
HSP70 overexpression has a remedying effect in neurodegenerative diseases. In Alzheimer's disease (AD), the suppressive effects of HSP70 overexpression on AD-related phenotypes and the underlying mechanisms are unknown. In the current study, the effect of geranylgeranylacetone (GGA), a non-toxic inducer of heat shock protein (HSP)-70 expression, on cognitive function and other pathological phenotypes were evaluated in APP/PS1 mice. It was observed that all doses of orally administered GGA (200, 400, and 800 mg/kg/day) improved cognitive deficit (P<0...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29284815/rehabilitation-in-schizophrenia-a-brain-behavior-and-psychosocial-perspective
#18
Jamuna Rajeswaran, Aarati Taksal, Sanjeev Jain
Cognitive deficits in patients with schizophrenia have been documented consistently. They are known to contribute to functional impairment in patients. Cognitive remediation has been found to be beneficial in symptoms reduction and functional recovery. CH was a 26/F, completed her graduation, currently pursuing a management course through correspondence, unmarried, currently living with her parents, from Bengaluru, right-handed, Middle socio economic status (MSES). A diagnosis of paranoid schizophrenia was referred for cognitive assessment and rehabilitation...
November 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29282160/emotion-recognition-correlates-with-social-neuropsychiatric-dysfunction-in-huntington-s-disease
#19
Clare L Kempnich, Sophie C Andrews, Fiona Fisher, Dana Wong, Nellie Georgiou-Karistianis, Julie C Stout
OBJECTIVES: People with Huntington's disease (HD) experience poor social quality of life, relationship breakdown, and social withdrawal, which are mediated to some extent by socially debilitating neuropsychiatric symptoms, such as apathy and disinhibition. Social cognitive symptoms, such as impaired emotion recognition, also occur in HD, however, the extent of their association with these socially debilitating neuropsychiatric symptoms is unknown. Our study examined the relationship between emotion recognition and symptom ratings of apathy and disinhibition in HD...
December 28, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29278718/a-randomised-controlled-trial-of-manualized-cognitive-remediation-therapy-in-adult-obesity
#20
Jayanthi Raman, Phillipa Hay, Kate Tchanturia, Evelyn Smith
OBJECTIVE: Research has indicated that individuals with obesity have neurocognitive deficits, especially in cognitive flexibility that may in turn impact on their weight loss and maintenance. Consequently, we examined the efficacy of a manualised face-to-face cognitive remediation therapy for obesity (CRT-O) within a randomised controlled trial, in terms of improving cognitive flexibility, reducing binge eating behavior, improving quality of life and helping with weight loss. METHODS: 80 adults with obesity (body mass index >30 kg/m2), 70% binge eaters, received three weekly sessions of group Behavioural Weight Loss (BWL) and then were randomised to 8 sessions of individual CRT-O or to a no-treatment control group...
December 23, 2017: Appetite
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