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Cognitive remediation

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https://www.readbyqxmd.com/read/29666372/brain-serotonin-synthesis-capacity-in-obsessive-compulsive-disorder-effects-of-cognitive-behavioral-therapy-and-sertraline
#1
Jennifer I Lissemore, Debbie Sookman, Paul Gravel, Alexandre Berney, Amir Barsoum, Mirko Diksic, Thomas E Nordahl, Gilbert Pinard, Igor Sibon, Jean Cottraux, Marco Leyton, Chawki Benkelfat
Cognitive behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs) are both effective treatments for some patients with obsessive-compulsive disorder (OCD), yet little is known about the neurochemical changes related to these treatment modalities. Here, we used positron emission tomography and the α-[11 C]methyl-L-tryptophan tracer to examine the changes in brain regional serotonin synthesis capacity in OCD patients following treatment with CBT or SSRI treatment. Sixteen medication-free OCD patients were randomly assigned to 12 weeks of either CBT or sertraline treatment...
April 18, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29661241/breaking-bad-habits-by-improving-executive-function-in-individuals-with-obesity
#2
Vanessa Allom, Barbara Mullan, Evelyn Smith, Phillipa Hay, Jayanthi Raman
BACKGROUND: Two primary factors that contribute to obesity are unhealthy eating and sedentary behavior. These behaviors are particularly difficult to change in the long-term because they are often enacted habitually. Cognitive Remediation Therapy has been modified and applied to the treatment of obesity (CRT-O) with preliminary results of a randomized controlled trial demonstrating significant weight loss and improvements in executive function. The objective of this study was to conduct a secondary data analysis of the CRT-O trial to evaluate whether CRT-O reduces unhealthy habits that contribute to obesity via improvements in executive function...
April 16, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29661156/synergic-trial-synchronizing-exercises-remedies-in-gait-and-cognition-a-multi-centre-randomized-controlled-double-blind-trial-to-improve-gait-and-cognition-in-mild-cognitive-impairment
#3
Manuel Montero-Odasso, Quincy J Almeida, Amer M Burhan, Richard Camicioli, Julien Doyon, Sarah Fraser, Karen Li, Teresa Liu-Ambrose, Laura Middleton, Susan Muir-Hunter, William McIlroy, José A Morais, Frederico Pieruccini-Faria, Kevin Shoemaker, Mark Speechley, Akshya Vasudev, G Y Zou, Nicolas Berryman, Maxime Lussier, Leanne Vanderhaeghe, Louis Bherer
BACKGROUND: Physical exercise, cognitive training, and vitamin D are low cost interventions that have the potential to enhance cognitive function and mobility in older adults, especially in pre-dementia states such as Mild Cognitive Impairment (MCI). Aerobic and progressive resistance exercises have benefits to cognitive performance, though evidence is somewhat inconsistent. We postulate that combined aerobic exercise (AE) and progressive resistance training (RT) (combined exercise) will have a better effect on cognition than a balance and toning control (BAT) intervention in older adults with MCI...
April 16, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29660304/circadian-rhythm-resynchronization-improved-isoflurane-induced-cognitive-dysfunction-in-aged-mice
#4
Jia Song, Shuaishuai Chu, Yin Cui, Yue Qian, Xiuxiu Li, Fangxia Xu, Xueming Shao, Zhengliang Ma, Tianjiao Xia, Xiaoping Gu
Postoperative cognitive dysfunction (POCD) is a common clinical phenomenon characterized by cognitive deficits in patients after anesthesia and surgery. Advanced age is a significant independent risk factor for POCD. We previously reported that in young mice, sleep-wake rhythm is involved in the isoflurane-induced memory impairment. In present study, we sought to determine whether advanced age increased the risk of POCD through aggravated and prolonged post-anesthetic circadian disruption in the elderly. We constructed POCD model by submitting the mice to 5-h 1...
April 13, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29656823/-association-splitting-versus-cognitive-remediation-in-obsessive-compulsive-disorder-a-randomized-controlled-trial
#5
Lena Jelinek, Marit Hauschildt, Birgit Hottenrott, Michael Kellner, Steffen Moritz
Studies have confirmed the efficacy of the cognitive intervention Association Splitting (AS) in obsessive-compulsive disorder (OCD) when applied as a self-help technique. AS aims to alter symptom-provoking automated cognitive networks of OC-related stimuli by building new or strengthening established but weak neutral associations. The aim of this study was to investigate the acceptance and benefits of therapist-assisted AS as an add-on to cognitive behavioral therapy (CBT). One hundred and nine patients with OCD who were undergoing CBT were randomly assigned to either AS or cognitive remediation (CR)...
March 31, 2018: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29615940/impact-of-cognitive-remediation-therapy-on-neurocognitive-processing-in-anorexia-nervosa
#6
Jenni Leppanen, James Adamson, Kate Tchanturia
Background: Anorexia nervosa (AN) is characterized by severe malnutrition as well as inefficiencies in neurocognitive functioning, which are believed to contribute to the maintenance of disordered eating. The aim of this study was to examine the impact of individual cognitive remediation therapy (CRT) on neurocognition in AN. Methods: A total of 145 adult women from an eating disorders inpatient program took part in the present study. All participants were given individual CRT in addition to treatment as usual...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29607773/acceptability-and-perceived-effectiveness-of-cognitive-remediation-in-clinical-practice
#7
C Soumet-Leman, A Medalia, M D Erlich
No abstract text is available yet for this article.
April 1, 2018: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/29587688/computer-assisted-cognitive-remediation-therapy-increases-hippocampal-volume-in-patients-with-schizophrenia-a-randomized-controlled-trial
#8
Tsubasa Morimoto, Yasuhiro Matsuda, Kiwamu Matsuoka, Fumihiko Yasuno, Emi Ikebuchi, Hiroyuki Kameda, Toshiaki Taoka, Toshiteru Miyasaka, Kimihiko Kichikawa, Toshifumi Kishimoto
BACKGROUND: Cognitive remediation therapy (CRT) effectively reduces neurocognitive impairment in patients with schizophrenia, but few studies have used structural neuroimaging methods to assess its neuroanatomical effects. We investigated these effects, as well as the association between changes in cortical volume and neurocognitive performance. METHOD: Between August 2013 and September 2016, we performed a randomized controlled study comprising a CRT group (16 individuals) and a treatment-as-usual (TAU) group (15 individuals) of patients with schizophrenia...
March 27, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29580264/improving-recovery-and-outcomes-every-day-after-the-icu-improve-study-protocol-for-a-randomized-controlled-trial
#9
Sophia Wang, Jessica Hammes, Sikandar Khan, Sujuan Gao, Amanda Harrawood, Stephanie Martinez, Lyndsi Moser, Anthony Perkins, Frederick W Unverzagt, Daniel O Clark, Malaz Boustani, Babar Khan
BACKGROUND: Delirium affects nearly 70% of older adults hospitalized in the intensive care unit (ICU), and many of those will be left with persistent cognitive impairment or dementia. There are no effective and scalable recovery models to remediate ICU-acquired cognitive impairment and its attendant elevated risk for dementia or Alzheimer disease (AD). The Improving Recovery and Outcomes Every Day after the ICU (IMPROVE) trial is an ongoing clinical trial which evaluates the efficacy of a combined physical exercise and cognitive training on cognitive function among ICU survivors 50 years and older who experienced delirium during an ICU stay...
March 27, 2018: Trials
https://www.readbyqxmd.com/read/29577512/cognitive-remediation-therapy-crt-in-a-specialist-inpatient-eating-disorder-service-for-children-and-adolescents-can-crt-study-protocol-for-a-pilot-randomised-controlled-trial
#10
Lucia Giombini, Sophie Nesbitt, Hannah Cox, Anna Foxall, Teo Sharia, Abigail Easter, Kate Tchanturia
INTRODUCTION: Research on treatments for young people (YP) with anorexia nervosa (AN) is scarce. Evidence supports the use of cognitive remediation therapy (CRT) to improve central coherence and set-shifting, inefficiencies that can negatively impact on prognosis. OBJECTIVE: The study aims to evaluate the feasibility of individual CRT in an inpatient setting for YP aged 10-18 years with AN and to qualitatively examine YP's and their parents experiences. METHOD: In a single-centre, pilot, randomised controlled trial, 80 patients aged 10-18 years with AN will be randomly allocated to the immediate or delayed CRT group, in addition to standard treatment...
March 26, 2018: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/29562853/virtual-remediation-versus-methylphenidate-to-improve-distractibility-in-children-with-adhd-a-controlled-randomized-clinical-trial-study
#11
Stéphanie Bioulac, Jean-Arthur Micoulaud-Franchi, Jenna Maire, Manuel P Bouvard, Albert A Rizzo, Patricia Sagaspe, Pierre Philip
OBJECTIVE: Virtual environments have been used to assess children with ADHD but have never been tested as therapeutic tools. We tested a new virtual classroom cognitive remediation program to improve symptoms in children with ADHD. METHOD: In this randomized clinical trial, 51 children with ADHD (7-11 years) were assigned to a virtual cognitive remediation group, a methylphenidate group, or a psychotherapy group. All children were evaluated before and after therapy with an ADHD Rating Scale, a Continuous Performance Test (CPT), and a virtual classroom task...
March 1, 2018: Journal of Attention Disorders
https://www.readbyqxmd.com/read/29560919/thalamocortical-functional-connectivity-cognitive-impairment-and-cognitive-remediation-in-schizophrenia
#12
Neil D Woodward
No abstract text is available yet for this article.
May 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/29553037/cognitive-impairment-in-patients-with-neuropsychiatric-and-non-neuropsychiatric-systemic-lupus-erythematosus-a-systematic-review-and-meta-analysis
#13
Arantzazu Zabala, Monika Salgueiro, Oihane Sáez-Atxukarro, Javier Ballesteros, Guillermo Ruiz-Irastorza, Rafael Segarra
OBJECTIVES: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease. Its most prevalent manifestation is neuropsychiatric SLE (NP-SLE), which is characterized by increased involvement of the nervous system, with relevant symptoms, such as marked cognitive deficits, which are directly involved in subsequent functional disability. The objective of this study is to identify and compare the profile of cognitive deficits in patients with NP-SLE and patients with non-neuropsychiatric SLE (nonNP-SLE) by means of a systematic review and meta-analysis...
March 19, 2018: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/29544551/the-circuits-study-implementation-of-cognitive-remediation-in-early-intervention-services-protocol-for-a-randomised-controlled-trial
#14
Til Wykes, Eileen Joyce, Tjasa Velikonja, Andrew Watson, Gregory Aarons, Max Birchwood, Matteo Cella, Sue Dopson, David Fowler, Kathy Greenwood, Sonia Johnson, Paul McCrone, Jesus Perez, Andrew Pickles, Clare Reeder, Diana Rose, Swaran Singh, Dominic Stringer, Matthew Taylor, Rumina Taylor, Rachel Upthegrove
BACKGROUND: Cognitive problems in people with schizophrenia predict poor functional recovery even with the best possible rehabilitation opportunities and optimal medication. A psychological treatment known as cognitive remediation therapy (CRT) aims to improve cognition in neuropsychiatric disorders, with the ultimate goal of improving functional recovery. Studies suggest that intervening early in the course of the disorder will have the most benefit, so this study will be based in early intervention services, which treat individuals in the first few years following the onset of the disorder...
March 15, 2018: Trials
https://www.readbyqxmd.com/read/29542258/cognitive-remediation-therapy-for-adolescent-inpatients-with-severe-and-complex-anorexia-nervosa-a-treatment-trial
#15
Amy Harrison, Pamela Stavri, Lynn Ormond, Francine McEnemy, Dilan Akyol, Annum Qureshi, Hind Al-Khairulla
Cognitive remediation therapy (CRT) is a low-intensity treatment adjunct for individuals with severe and complex anorexia nervosa (AN) with difficulties in globally oriented, flexible thinking. Previously trialled in adults, this study investigated whether individual and group CRT was a feasible, acceptable, and beneficial treatment for 125 adolescent inpatients with severe and complex AN. Seventy patients (mean age = 15.22, SD = 1.44) received 10 sessions of individual CRT, and 55 patients (mean age = 14...
March 15, 2018: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/29541534/the-impact-of-cognitive-remediation-on-cerebral-activity-in-schizophrenia-systematic-review-of-the-literature
#16
Laura Bon, Nicolas Franck
Context: cognitive remediation involves either intensive training of impaired functions or implementing strategies to compensate for these impairments. In cases of schizophrenia, both methods have demonstrated benefits in terms of behavior and cerebral activity. However, despite the major differences between these two approaches, their impact has not yet been compared. Method: We searched the PsychInfo, Pubmed, and ScienceDirect databases using the key words "cognitive remediation," "schizophrenia," "cerebral activity," and "magnetic resonance imaging," in order to select studies investigating the effects of cognitive remediation on patients with schizophrenia...
March 2018: Brain and Behavior
https://www.readbyqxmd.com/read/29540913/brief-screening-for-cognitive-impairment-in-addictive-disorders
#17
Arun Gupta, Pratima Murthy, Shobini Rao
Chronic use of mind altering substances can lead to a wide variety of neuropsychological deficits, affecting the domains of attention, learning, memory, reasoning. Executive functions such as working memory, cognitive flexibility and inhibitory control may specifically be impaired. These deficits can impact engagement in effective psychosocial interventions. Mild to moderate cognitive dysfunction may not be picked up in routine clinical examination or through commonly used tests like the mini-mental state examination (MMSE)...
February 2018: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29536121/-schizophrenia-and-bipolar-disorder-treatment-of-cognitive-impairments
#18
REVIEW
P Riedel, M N Smolka, M Bauer
More than half of the patients diagnosed with schizophrenia and a subgroup of patients diagnosed with bipolar disorder show impairment in neurocognitive and social cognitive performance. The degree of impairment varies from person to person. An improvement of cognitive impairment results in increased subjective quality of life and increased psychosocial functioning, to a much greater extent than successful treatment of other symptoms. Therefore, it is reasonable to not only recognize and bear decreased cognitive functioning in mind but also to offer specific treatment of impairments...
March 13, 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29535847/evaluating-web-based-cognitive-affective-remediation-in-recent-trauma-survivors-study-rationale-and-protocol
#19
REVIEW
Naomi B Fine, Michal Achituv, Amit Etkin, Ofer Merin, Arieh Y Shalev
Background : The immediate aftermath of traumatic events is a period of enhanced neural plasticity, following which some survivors remain with post-traumatic stress disorder (PTSD) whereas others recover. Evidence points to impairments in emotional reactivity, emotion regulation, and broader executive functions as critically contributing to PTSD. Emerging evidence further suggests that the neural mechanisms underlying these functions remain plastic in adulthood and that targeted retraining of these systems may enhance their efficiency and could reduce the likelihood of developing PTSD...
2018: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/29527169/-orthosiphon-stamineus-leaf-extract-affects-tnf-%C3%AE-and-seizures-in-a-zebrafish-model
#20
Brandon Kar Meng Choo, Uday P Kundap, Yatinesh Kumari, Seow-Mun Hue, Iekhsan Othman, Mohd Farooq Shaikh
Epileptic seizures result from abnormal brain activity and can affect motor, autonomic and sensory function; as well as, memory, cognition, behavior, or emotional state. Effective anti-epileptic drugs (AEDs) are available but have tolerability issues due to their side effects. The Malaysian herb Orthosiphon stamineus , is a traditional epilepsy remedy and possesses anti-inflammatory, anti-oxidant and free-radical scavenging abilities, all of which are known to protect against seizures. This experiment thus aimed to explore if an ethanolic leaf extract of O...
2018: Frontiers in Pharmacology
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