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Cognitive remediation

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https://www.readbyqxmd.com/read/29045770/treatment-to-enhance-cognition-in-bipolar-disorder-trec-bd-efficacy-of-a-randomized-controlled-trial-of-cognitive-remediation-versus-active-control
#1
Kathryn E Lewandowski, Sarah H Sperry, Bruce M Cohen, Lesley A Norris, Garrett M Fitzmaurice, Dost Ongur, Matcheri S Keshavan
OBJECTIVE: Cognitive dysfunction is a core symptom dimension in bipolar disorder and a strong predictor of functional outcomes. Cognitive remediation (CR) produces moderate, durable effects on cognition in patients with schizophrenia; however, studies of CR in patients with bipolar disorder are sparse and findings have been mixed. Thus, the aim of this study was to evaluate the effects of CR versus active control in patients with bipolar disorder with psychosis. METHODS: Patients with a DSM-IV diagnosis of bipolar disorder with psychosis (n = 75) were randomized to a 70-hour computerized CR program or a dose-matched computer control using a parallel design with 1:1 allocation between July 2011 and November 2015...
October 17, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29021765/enhancing-neuroplasticity-to-augment-cognitive-remediation-in-schizophrenia
#2
REVIEW
Carol Jahshan, Yuri Rassovsky, Michael F Green
There is a burgeoning need for innovative treatment strategies to improve the cognitive deficits in schizophrenia. Cognitive remediation (CR) is effective at the group level, but the variability in treatment response is large. Given that CR may depend on intact neuroplasticity to produce cognitive gains, it is reasonable to combine it with strategies that harness patients' neuroplastic potential. In this review, we discuss two non-pharmacological approaches that can enhance neuroplasticity and possibly augment the effects of CR in schizophrenia: physical exercise and transcranial direct current stimulation (tDCS)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29020472/effect-of-transcranial-direct-current-stimulation-combined-with-cognitive-training-on-cognitive-functioning-in-older-adults-with-hiv-a-pilot-study
#3
Pariya L Fazeli, Adam J Woods, Caitlin N Pope, David E Vance, Karlene K Ball
The objective of this study was to examine combination speed of processing (SOP) cognitive remediation therapy (CRT) and transcranial direct stimulation (tDCS) as neurorehabilitation in older HIV+ adults. Thirty-three HIV+ adults aged 50+ completed neurocognitive testing and were randomized to either active (n = 17) or sham (n = 16) tDCS. Both conditions received 10 1-hour sessions of SOP CRT, with either active or sham tDCS for the first 20 minutes. Participants then completed a posttest assessment...
October 11, 2017: Applied Neuropsychology. Adult
https://www.readbyqxmd.com/read/28993740/pharmacological-augmentation-of-psychosocial-and-remediation-training-efforts-in-schizophrenia
#4
REVIEW
Philip D Harvey, Michael Sand
Pharmacological approaches to cognitive enhancement have received considerable attention but have not had considerable success in improving their cognitive and functional targets. Other intervention strategies, such as cognitive remediation therapy (CRT), have been shown to enhance cognitive performance but have not been found to improve functional outcomes without additional psychosocial interventions. Recently, several studies have attempted to enhance the effects of CRT by adding pharmacological interventions to the CRT treatments...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28967441/using-visual-processing-training-to-enhance-standard-cognitive-remediation-outcomes-in-schizophrenia-a-pilot-study
#5
Natalia A Contreras, Eric J Tan, Stuart J Lee, David J Castle, Susan L Rossell
Approaches to cognitive remediation (CR) that address sensory perceptual skills before higher cognitive skills, have been found to be effective in enhancing cognitive performance in schizophrenia. To date, however, most of the conducted trials have concentrated on auditory processing. The aim of this study was to explore whether the addition of visual processing training could enhance standard cognitive remediation outcomes in a schizophrenia population. Twenty participants were randomised to either receive 20h of computer-assisted cognitive remediation alone or 20h of visual processing training modules and cognitive remediation training...
September 14, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28965777/white-matter-microstructure-and-cognitive-remediation-outcomes-in-schizophrenia
#6
Sinead M Kelly, Shaun M Eack
No abstract text is available yet for this article.
September 28, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28958607/evidenced-based-cognitive-rehabilitation-for-persons-with-multiple-sclerosis-an-updated-review-of-the-literature-from-2007-2016
#7
REVIEW
Y Goverover, N D Chiaravalloti, A O'Brien, J DeLuca
OBJECTIVE: To update the clinical recommendations for cognitive rehabilitation of people with Multiple Sclerosis (MS), based on a systematic review of the literature from 2007 through 2016. DATA SOURCES: Searches of Medline, PsychInfo, and CINAHL with a combinations of the following terms: attention, awareness, cognition, cognitive, communication, executive, executive function, language, learning, memory, perception, problem solving, reasoning, rehabilitation, remediation, training, processing speed, and working memory, were conducted...
September 25, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28954595/subjective-objective-sleep-discrepancy-in-older-adults-with-mci-and-subsyndromal-depression
#8
Elizabeth A DiNapoli, Marie Anne Gebara, Terry Kho, Meryl A Butters, Ariel G Gildengers, Steven M Albert, Mary Amanda Dew, Kirk I Erickson, Charles F Reynolds, Jordan F Karp
BACKGROUND/OBJECTIVES: We investigated the prevalence and correlates of discrepancies between self-reported sleep quality (Pittsburgh Sleep Quality Index) and objective sleep efficiency (actigraphy) in older adults with mild cognitive impairment (MCI) and subsyndromal depression. METHODS: This was a secondary analysis of a clincial trial with 59 adults aged 60 years and older with MCI and subsyndromal depression. We included baseline data on participants' subjective sleep quality, objective sleep efficiency, depressive symptoms, insomnia diagnosis, and cognitive functioning...
January 1, 2017: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/28953781/is-there-an-optimal-cognitive-application-to-be-used-for-cognitive-remediation-in-clinical-psychiatric-practice
#9
Avriel McDonnell, Mark Agius, Yuliya Zaytseva
Cognitive dysfunction is a common characteristic across a number of psychiatric conditions. With growing technological advances, application based cognitive remediation (cognitive apps) is becoming steadily popular due to its accessibility, ease of use and minimal interference with the activities of daily life. However, despite a number of benefits that application based cognitive training possesses, it is not clear, whether the utilisation of these apps is a reliable approach that can be recommended in clinical psychiatric practice in order to restore cognition...
September 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/28952154/assessment-and-conceptual-remediation-of-basic-calculation-skills-in-elementary-school-students
#10
Elen S Karakonstantaki, Panagiotis G Simos, Vamvukas Michalis, Sifis Micheloyannis
The specific domain model for math disabilities postulates a core number deficit which presents a prime target for remedial interventions. This longitudinal study identified two groups of Grade 3 students based on their basic calculation abilities: students with persistent difficulties through Grade 4 (PD group) and students whose performance improved into the average range (IP group). Baseline data revealed a distinct cognitive profile for students in the PD group featuring predominant deficits in symbolic number processing...
September 26, 2017: British Journal of Developmental Psychology
https://www.readbyqxmd.com/read/28950781/blockade-of-dopamine-d1-family-receptors-attenuates-the-mania-like-hyperactive-risk-preferring-and-high-motivation-behavioral-profile-of-mice-with-low-dopamine-transporter-levels
#11
Morgane Milienne-Petiot, Lucianne Groenink, Arpi Minassian, Jared W Young
BACKGROUND: Patients with bipolar disorder mania exhibit poor cognition, impulsivity, risk-taking, and goal-directed activity that negatively impact their quality of life. To date, existing treatments for bipolar disorder do not adequately remediate cognitive dysfunction. Reducing dopamine transporter expression recreates many bipolar disorder mania-relevant behaviors (i.e. hyperactivity and risk-taking). The current study investigated whether dopamine D1-family receptor blockade would attenuate the risk-taking, hypermotivation, and hyperactivity of dopamine transporter knockdown mice...
October 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28943708/executive-functioning-deficits-increase-kindergarten-children-s-risk-for-reading-and-mathematics-difficulties-in-first-grade
#12
Paul L Morgan, Hui Li, George Farkas, Michael Cook, Wik Hung Pun, Marianne M Hillemeier
Whether executive functioning deficits result in children experiencing learning difficulties is presently unclear. Yet evidence for these hypothesized causal relations has many implications for early intervention design and delivery. We used a multi-year panel design, multiple criterion and predictor variable measures, extensive statistical control for potential confounds including autoregressive prior histories of both reading and mathematics difficulties, and additional epidemiological methods to preliminarily examine these hypothesized relations...
July 2017: Contemporary Educational Psychology
https://www.readbyqxmd.com/read/28941093/staging-in-bipolar-disorder-from-theoretical-framework-to-clinical-utility
#13
Michael Berk, Robert Post, Aswin Ratheesh, Emma Gliddon, Ajeet Singh, Eduard Vieta, Andre F Carvalho, Melanie M Ashton, Lesley Berk, Susan M Cotton, Patrick D McGorry, Brisa S Fernandes, Lakshmi N Yatham, Seetal Dodd
Illness staging is widely utilized in several medical disciplines to help predict course or prognosis, and optimize treatment. Staging models in psychiatry in general, and bipolar disorder in particular, depend on the premise that psychopathology moves along a predictable path: an at-risk or latency stage, a prodrome progressing to a first clinical threshold episode, and one or more recurrences with the potential to revert or progress to late or end-stage manifestations. The utility and validity of a staging model for bipolar disorder depend on its linking to clinical outcome, treatment response and neurobiological measures...
October 2017: World Psychiatry: Official Journal of the World Psychiatric Association (WPA)
https://www.readbyqxmd.com/read/28937497/cognitive-skills-training-for-homeless-transition-age-youth-feasibility-and-pilot-efficacy-of-a-community-based-randomized-controlled-trial
#14
Alice Medalia, Alice M Saperstein, Yanlan Huang, Seonjoo Lee, Elizabeth J Ronan
Cognitive impairments are common in homeless youth and negatively impact academic and vocational outcomes. We examined the feasibility and efficacy of cognitive interventions provided to 18- to 22-year-old homeless youth living in urban supportive housing. Ninety-one homeless youth were randomized to receive either targeted cognitive training (cognitive remediation) or general cognitive activation (computer skills training). Cognitive and psychological outcomes were assessed at baseline, after 13 and 26 sessions, and 1 month postintervention...
September 20, 2017: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/28933314/effectiveness-of-a-low-support-remotely-accessible-cognitive-remediation-training-programme-for-chronic-psychosis-cognitive-functional-and-cortical-outcomes-from-a-single-blind-randomised-controlled-trial
#15
G Donohoe, R Dillon, A Hargreaves, O Mothersill, M Castorina, E Furey, A J Fagan, J F Meaney, B Fitzmaurice, B Hallahan, C McDonald, T Wykes, A Corvin, I H Robertson
BACKGROUND: Cognitive remediation (CR) training has emerged as a promising approach to improving cognitive deficits in schizophrenia and related psychosis. The limited availability of psychological services for psychosis is a major barrier to accessing this intervention however. This study investigated the effectiveness of a low support, remotely accessible, computerised working memory (WM) training programme in patients with psychosis. METHODS: Ninety patients were enrolled into a single blind randomised controlled trial of CR...
September 21, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28931500/web-based-cognitive-remediation-improves-supported-employment-outcomes-in-severe-mental-illness-randomized-controlled-trial
#16
Anthony Wf Harris, Tanya Kosic, Jean Xu, Chris Walker, William Gye, Antoinette Redoblado Hodge
BACKGROUND: Finding work is a top priority for most people; however, this goal remains out of reach for the majority of individuals with a severe mental illness (SMI) who remain on benefits or are unemployed. Supported employment (SE) programs aimed at returning people with a severe mental illness to work are successful; however, they still leave a significant number of people with severe mental illness unemployed. Cognitive deficits are commonly found in SMI and are a powerful predictor of poor outcome...
September 20, 2017: JMIR Mental Health
https://www.readbyqxmd.com/read/28931460/brief-executive-function-training-for-individuals-with-severe-mental-illness-effects-on-eeg-synchronization-and-executive-functioning
#17
Michael W Best, Daniel Gale, Tanya Tran, Mashal K Haque, Christopher R Bowie
BACKGROUND: Executive Functioning (EF) is an important factor for community functioning for people with severe mental illness. Cognitive remediation programs often improve EF, but do so by using multiple therapeutic techniques. Little is known regarding how individual treatment elements promote cognitive improvement. Oscillatory brain activity is a potential neurophysiological mechanism that may change as a result of targeted training on computerized exercises. The current study aimed to examine the effects of a brief EF training program on EEG and neurocognitive measures...
September 18, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28925573/achieving-recovery-in-patients-with-schizophrenia-through-psycho-social-interventions-a-retrospective-study
#18
Mariachiara Buonocore, Marta Bosia, Maria Alice Baraldi, Margherita Bechi, Marco Spangaro, Federica Cocchi, Laura Bianchi, Carmelo Guglielmino, Antonella Rita Mastromatteo, Roberto Cavallaro
AIM: Recovery, or functional remission represents the ultimate treatment goal in schizophrenia. Despite its importance, a standardized definition of remission is still lacking, thus reported rates significantly vary across studies. Moreover, the effects of rehabilitative interventions on recovery are still poorly investigated. This study aims to evaluate recovery in a sample of patients with chronic schizophrenia engaged in rehabilitation programs and to explore contributing factors, with a focus on of socio-cognitive rehabilitative interventions...
September 19, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28919130/the-nuts-and-bolts-of-cognitive-remediation-exploring-how-different-training-components-relate-to-cognitive-and-functional-gains
#19
Matteo Cella, Til Wykes
BACKGROUND: Cognitive Remediation (CR) is an evidence based treatment targeting cognitive and functional difficulties in people with psychosis. Despite the large number of effectiveness studies, only limited evidence exists for the active ingredients of this therapy. This study begins to fill this gap by exploring the relationship between CR ingredients, including alliance with a therapist, and therapy outcomes. METHOD: This is a secondary analysis based on data from a published randomised controlled trial comparing CR+treatment-as-usual (TAU) to TAU alone...
September 14, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28912154/inhibition-of-p25-cdk5-attenuates-tauopathy-in-mouse-and-ipsc-models-of-frontotemporal-dementia
#20
Jinsoo Seo, Oleg Kritskiy, L Ashley Watson, Scarlett J Barker, Dilip Dey, Waseem K Raja, Yuan-Ta Lin, Tak Ko, Sukhee Cho, Jay Penney, M Catarina Silva, Steven D Sheridan, Diane Lucente, James F Gusella, Bradford C Dickerson, Stephen J Haggarty, Li-Huei Tsai
Increased p25, a proteolytic fragment of the regulatory subunit p35, is known to induce aberrant activity of cyclin-dependent kinase 5 (Cdk5), which is associated with neurodegenerative disorders including Alzheimer's disease (AD). Previously, we showed that replacing endogenous p35 with the non-cleavable mutant p35 (Δp35) attenuated amyloidosis and improved cognitive function in a familial AD mouse model. Here, to address the role of p25/Cdk5 in tauopathy, we generated double transgenic mice by crossing mice overexpressing mutant human tau (P301S) with Δp35KI mice...
September 14, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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