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https://www.readbyqxmd.com/read/27895488/advances-in-the-management-of-heart-failure-the-role-of-ivabradine
#1
REVIEW
Ursula Müller-Werdan, Georg Stöckl, Karl Werdan
A high resting heart rate (≥70-75 b.p.m.) is a risk factor for patients with heart failure (HF) with reduced ejection fraction (EF), probably in the sense of accelerated atherosclerosis, with an increased morbidity and mortality. Beta-blockers not only reduce heart rate but also have negative inotropic and blood pressure-lowering effects, and therefore, in many patients, they cannot be given in the recommended dose. Ivabradine specifically inhibits the pacemaker current (funny current, If) of the sinoatrial node cells, resulting in therapeutic heart rate lowering without any negative inotropic and blood pressure-lowering effect...
2016: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/27886711/eeg-epochs-with-less-alpha-rhythm-improve-discrimination-of-mild-alzheimer-s
#2
Paulo A M Kanda, Eliezyer F Oliveira, Francisco J Fraga
BACKGROUND AND OBJECTIVE: Eyes-closed-awake electroencephalogram (EEG) is a useful tool in the diagnosis of Alzheimer's. However, there is eyes-closed-awake EEG with dominant or rare alpha rhythm. In this paper, we show that random selection of EEG epochs disregarding the alpha rhythm will lead to bias concerning EEG-based Alzheimer's Disease diagnosis. METHODS: We compared EEG epochs with more than 30% and with less than 30% alpha rhythm of mild Alzheimer's Disease patients and healthy elderly...
January 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/27881788/brain-network-mechanisms-underlying-motor-enhancement-by-transcranial-entrainment-of-gamma-oscillations
#3
Marius Moisa, Rafael Polania, Marcus Grueschow, Christian C Ruff
: Gamma and beta oscillations are routinely observed in motor-related brain circuits during movement preparation and execution. Entrainment of gamma or beta oscillations via transcranial alternating current stimulation (tACS) over primary motor cortex (M1) has opposite effects on motor performance, suggesting a causal role of these brain rhythms for motor control. However, it is largely unknown which brain mechanisms characterize these changes in motor performance brought about by tACS...
November 23, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27857215/taurine-treatment-modulates-circadian-rhythms-in-mice-fed-a-high-fat-diet
#4
Ana Lucia C Figueroa, Hugo Figueiredo, Sandra A Rebuffat, Elaine Vieira, Ramon Gomis
Close ties have been made among certain nutrients, obesity, type 2 diabetes and circadian clocks. Among nutrients, taurine has been documented as being effective against obesity and type 2 diabetes. However, the impact of taurine on circadian clocks has not been elucidated. We investigated whether taurine can modulate or correct disturbances in daily rhythms caused by a high-fat diet in mice. Male C57BL/6 mice were divided in four groups: control (C), control + taurine (C+T), high-fat diet (HFD) and HFD + taurine (HFD+T)...
November 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27846465/perioperative-atrial-fibrillation-is-associated-with-increased-one-year-mortality-in-elderly-patients-after-repair-of-hip-fracture
#5
David Leibowitz, Chen Abitbol, Ronny Alcalai, Gurion Rivkin, Leonid Kandel
BACKGROUND: Hip fracture repair is commonly performed in elderly adults and is associated with high mortality. Limited data address the significance of perioperative atrial fibrillation (AF) and its subsequent treatment in emergent orthopedic surgery in the elderly. This study aimed to determine whether newly diagnosed AF among patients initially in sinus rhythm undergoing hip fracture repair is predictive of one-year mortality and whether medical therapy of AF attenuated this finding...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27821966/effects-of-neurofeedback-training-on-the-brain-wave-of-adults-with-forward-head-posture
#6
Hyun-Ju Oh, Gui-Bin Song
[Purpose] The purpose of the present study was to examine the effects of neurofeedback training on electroencephalogram changes in the cervical spine in adults with forward head posture through x-ray. [Subjects and Methods] The subjects of the study were 40 college students with forward head posture, randomly divided into a neurofeedback training group (NFTG, n=20) and a control group (CG, n=20). The neurofeedback training group performed six sessions of pottery and archery games, each for two minutes, three times per week for four weeks, while using the neurofeedback system...
October 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27821482/toward-an-attention-based-diagnostic-tool-for-patients-with-locked-in-syndrome
#7
Damien Lesenfants, Dina Habbal, Camille Chatelle, Andrea Soddu, Steven Laureys, Quentin Noirhomme
Electroencephalography (EEG) has been proposed as a supplemental tool for reducing clinical misdiagnosis in severely brain-injured populations helping to distinguish conscious from unconscious patients. We studied the use of spectral entropy as a measure of focal attention in order to develop a motor-independent, portable, and objective diagnostic tool for patients with locked-in syndrome (LIS), answering the issues of accuracy and training requirement. Data from 20 healthy volunteers, 6 LIS patients, and 10 patients with a vegetative state/unresponsive wakefulness syndrome (VS/UWS) were included...
November 7, 2016: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/27803121/new-onset-atrial-fibrillation-after-anatomic-lung-resection-predictive-factors-treatment-and-follow-up-in-a-uk-thoracic-centre
#8
Megan Garner, Tom Routledge, Juliet E King, John E Pilling, Lukacs Veres, Karen Harrison-Phipps, Andrea Bille, Leanne Harling
OBJECTIVES: Postoperative atrial fibrillation (POAF) increases morbidity, hospital stay and healthcare expenditure. This study aims to determine the perioperative factors correlating with POAF as well as to evaluate both treatment strategies and AF persistence beyond discharge. METHODS: The records of all patients undergoing anatomical lung resection over a 1-year period were retrospectively reviewed. Patients with a history of arrhythmia were excluded. POAF was defined by clinical diagnosis and electrocardiography...
November 1, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/27799677/clinical-usefulness-of-brain-computer-interface-controlled-functional-electrical-stimulation-for-improving-brain-activity-in-children-with-spastic-cerebral-palsy-a-pilot-randomized-controlled-trial
#9
Tae-Woo Kim, Byoung-Hee Lee
[Purpose] Evaluating the effect of brain-computer interface (BCI)-based functional electrical stimulation (FES) training on brain activity in children with spastic cerebral palsy (CP) was the aim of this study. [Subjects and Methods] Subjects were randomized into a BCI-FES group (n=9) and a functional electrical stimulation (FES) control group (n=9). Subjects in the BCI-FES group received wrist and hand extension training with FES for 30 minutes per day, 5 times per week for 6 weeks under the BCI-based program...
September 2016: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/27796320/orexin-signaling-regulates-both-the-hippocampal-clock-and-the-circadian-oscillation-of-alzheimer-s-disease-risk-genes
#10
Zhixiong Ma, Weiliang Jiang, Eric Erquan Zhang
Alzheimer's disease (AD) is a circadian clock-related disease. However, it is not very clear whether pre-symptomatic AD leads to circadian disruption or whether malfunction of circadian rhythms exerts influence on development of AD. Here, we report a functional clock that exists in the hippocampus. This oscillator both receives input signals and maintains the cycling of the hippocampal Per2 gene. One of the potential inputs to the oscillator is orexin signaling, which can shorten the hippocampal clock period and thereby regulate the expression of clock-controlled-genes (CCGs)...
October 31, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27795702/motor-imagery-classification-using-mu-and-beta-rhythms-of-eeg-with-strong-uncorrelating-transform-based-complex-common-spatial-patterns
#11
Youngjoo Kim, Jiwoo Ryu, Ko Keun Kim, Clive C Took, Danilo P Mandic, Cheolsoo Park
Recent studies have demonstrated the disassociation between the mu and beta rhythms of electroencephalogram (EEG) during motor imagery tasks. The proposed algorithm in this paper uses a fully data-driven multivariate empirical mode decomposition (MEMD) in order to obtain the mu and beta rhythms from the nonlinear EEG signals. Then, the strong uncorrelating transform complex common spatial patterns (SUTCCSP) algorithm is applied to the rhythms so that the complex data, constructed with the mu and beta rhythms, becomes uncorrelated and its pseudocovariance provides supplementary power difference information between the two rhythms...
2016: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/27790169/large-scale-functional-brain-networks-underlying-temporal-integration-of-audio-visual-speech-perception-an-eeg-study
#12
G Vinodh Kumar, Tamesh Halder, Amit K Jaiswal, Abhishek Mukherjee, Dipanjan Roy, Arpan Banerjee
Observable lip movements of the speaker influence perception of auditory speech. A classical example of this influence is reported by listeners who perceive an illusory (cross-modal) speech sound (McGurk-effect) when presented with incongruent audio-visual (AV) speech stimuli. Recent neuroimaging studies of AV speech perception accentuate the role of frontal, parietal, and the integrative brain sites in the vicinity of the superior temporal sulcus (STS) for multisensory speech perception. However, if and how does the network across the whole brain participates during multisensory perception processing remains an open question...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27718535/the-rhythm-of-the-executive-gate-of-speech-subthalamic-low-frequency-oscillations-increase-during-verbal-generation
#13
Lars Wojtecki, Saskia Elben, Jan Vesper, Alfons Schnitzler
We investigated neurophysiological mechanisms of subthalamic nucleus involvement in verbal fluency by means of a verbal generation task. The subthalamic nucleus is thought to act as a behavioural go/no-go instance by means of oscillatory communication in theta band with the prefrontal cortex. Because subthalamic alpha-theta frequency stimulation has been shown to exert beneficial effects on verbal fluency in Parkinson's disease, we hypothesized that an alpha-theta oscillatory network involving the subthalamic nucleus underlies verbal generation task performance as a gating instance for speech execution...
October 8, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27713698/stress-assessment-by-prefrontal-relative-gamma
#14
Jesus Minguillon, Miguel A Lopez-Gordo, Francisco Pelayo
Stress assessment has been under study in the last years. Both biochemical and physiological markers have been used to measure stress level. In neuroscience, several studies have related modification of stress level to brain activity changes in limbic system and frontal regions, by using non-invasive techniques such as functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). In particular, previous studies suggested that the exhibition or inhibition of certain brain rhythms in frontal cortical areas indicates stress...
2016: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/27634039/histone-deacetylase-sirt1-controls-proliferation-circadian-rhythm-and-lipid-metabolism-during-liver-regeneration-in-mice
#15
Marina Maria Bellet, Selma Masri, Giuseppe Astarita, Paolo Sassone-Corsi, Maria Agnese Della Fazia, Giuseppe Servillo
Liver regeneration offers a distinctive opportunity to study cell proliferation in vivo Mammalian silent information regulator 1 (SIRT1), a NAD(+)-dependent histone deacetylase, is an important regulator of various cellular processes, including proliferation, metabolism, and circadian rhythms. In the liver, SIRT1 coordinates the circadian oscillation of clock-controlled genes, including genes that encode enzymes involved in metabolic pathways. We performed partial hepatectomy in WT and liver-specific Sirt1-deficient mice and analyzed the expression of cell cycle regulators in liver samples taken at different times during the regenerative process, by real time PCR, Western blotting analysis, and immunohistochemistry...
October 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27613569/the-relationship-between-baseline-eeg-spectra-power-and-memory-performance-in-older-african-americans-endorsing-cognitive-concerns-in-a-community-setting
#16
Voyko Kavcic, Bojan Zalar, Bruno Giordani
The finding that some older individuals report declines in aspects of cognitive functioning is becoming a frequently used criteria to identify elderly at risk for mild cognitive impairment (MCI) and dementia. Once concerns are identified in a community setting, however, effective means are necessary to pinpoint those individuals who should go on to more complex and costly diagnostic evaluations (e.g., functional imaging). We tested 44 African American volunteers endorsing cognitive concerns (37 females, 7 males) age≥65years with CogState battery subtests and recorded resting-state EEG, with eyes closed...
November 2016: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/27590966/3d-hand-motion-trajectory-prediction-from-eeg-mu-and-beta-bandpower
#17
A Korik, R Sosnik, N Siddique, D Coyle
A motion trajectory prediction (MTP) - based brain-computer interface (BCI) aims to reconstruct the three-dimensional (3D) trajectory of upper limb movement using electroencephalography (EEG). The most common MTP BCI employs a time series of bandpass-filtered EEG potentials (referred to here as the potential time-series, PTS, model) for reconstructing the trajectory of a 3D limb movement using multiple linear regression. These studies report the best accuracy when a 0.5-2Hz bandpass filter is applied to the EEG...
2016: Progress in Brain Research
https://www.readbyqxmd.com/read/27557313/rate-control-or-rhythm-control-for-atrial-fibrillation-after-heart-surgery
#18
LETTER
Sergiu P Darabant, Irwin Hoffman
No abstract text is available yet for this article.
August 25, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27557312/rate-control-or-rhythm-control-for-atrial-fibrillation-after-heart-surgery
#19
LETTER
Alexander Sorisky
No abstract text is available yet for this article.
August 25, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27557311/rate-control-or-rhythm-control-for-atrial-fibrillation-after-heart-surgery
#20
LETTER
Jesus A Barea-Mendoza, Renata García-Gigorro, Emilio Renes-Carreño
No abstract text is available yet for this article.
August 25, 2016: New England Journal of Medicine
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