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https://www.readbyqxmd.com/read/28228305/clinical-presentation-management-and-outcomes-in-the-indian-heart-rhythm-society-atrial-fibrillation-ihrs-af-registry
#1
A Vora, A Kapoor, M Nair, Y Lokhandwala, C Narsimhan, A G Ravikishore, S K Dwivedi, N Namboodiri, R Hygriv, A Saxena, A Nabar, S Garg, N Bardoloi, R Yadav, A Nambiar, U Pandurangi, D Jhala, A Naik, Nagmallesh, S Rajagopal, R Selvaraj, V Arora, A Thachil, J Thomas, G Panicker
AIM: A national atrial fibrillation (AF) registry was conducted under the aegis of the Indian Heart Rhythm Society (IHRS), to capture epidemiological data-type of AF, clinical presentation and comorbidities, current treatment practices, and 1-year follow-up outcomes. METHODS: A total of 1537 patients were enrolled from 24 sites in India in the IHRS-AF registry from July 2011 to August 2012. Their baseline characteristics and follow-up data were recorded in case report forms and subsequently analyzed...
January 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28226795/soft-drink-effects-on-sensorimotor-rhythm-brain-computer-interface-performance-and-resting-state-spectral-power
#2
John Mundahl, Jianjun Meng, Jeffrey He, Bin He, John Mundahl, Jianjun Meng, Jeffrey He, Bin He, Jeffrey He, Jianjun Meng, John Mundahl, Bin He
Brain-computer interface (BCI) systems allow users to directly control computers and other machines by modulating their brain waves. In the present study, we investigated the effect of soft drinks on resting state (RS) EEG signals and BCI control. Eight healthy human volunteers each participated in three sessions of BCI cursor tasks and resting state EEG. During each session, the subjects drank an unlabeled soft drink with either sugar, caffeine, or neither ingredient. A comparison of resting state spectral power shows a substantial decrease in alpha and beta power after caffeine consumption relative to control...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225010/beta-phase-synchronization-in-the-frontal-temporal-cerebellar-network-during-auditory-to-motor-rhythm-learning
#3
Kouki Edagawa, Masahiro Kawasaki
Rhythm is an essential element of dancing and music. To investigate the neural mechanisms underlying how rhythm is learned, we recorded electroencephalographic (EEG) data during a rhythm-reproducing task that asked participants to memorize an auditory stimulus and reproduce it via tapping. Based on the behavioral results, we divided the participants into Learning and No-learning groups. EEG analysis showed that error-related negativity (ERN) in the Learning group was larger than in the No-learning group. Time-frequency analysis of the EEG data showed that the beta power in right and left temporal area at the late learning stage was smaller than at the early learning stage in the Learning group...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28223926/frontal-functional-connectivity-of-electrocorticographic-delta-and-theta-rhythms-during-action-execution-versus-action-observation-in-humans
#4
Claudio Babiloni, Claudio Del Percio, Susanna Lopez, Giancarlo Di Gennaro, Pier P Quarato, Luigi Pavone, Roberta Morace, Andrea Soricelli, Giuseppe Noce, Vincenzo Esposito, Vittorio Gallese, Giovanni Mirabella
We have previously shown that in seven drug-resistant epilepsy patients, both reaching-grasping of objects and the mere observation of those actions did desynchronize subdural electrocorticographic (ECoG) alpha (8-13 Hz) and beta (14-30) rhythms as a sign of cortical activation in primary somatosensory-motor, lateral premotor and ventral prefrontal areas (Babiloni et al., 2016a). Furthermore, that desynchronization was greater during action execution than during its observation. In the present exploratory study, we reanalyzed those ECoG data to evaluate the proof-of-concept that lagged linear connectivity (LLC) between primary somatosensory-motor, lateral premotor and ventral prefrontal areas would be enhanced during the action execution compared to the mere observation due to a greater flow of visual and somatomotor information...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28216627/layer-specific-optogenetic-activation-of-pyramidal-neurons-causes-beta-gamma-entrainment-of-neonatal-networks
#5
Sebastian H Bitzenhofer, Joachim Ahlbeck, Amy Wolff, J Simon Wiegert, Christine E Gee, Thomas G Oertner, Ileana L Hanganu-Opatz
Coordinated activity patterns in the developing brain may contribute to the wiring of neuronal circuits underlying future behavioural requirements. However, causal evidence for this hypothesis has been difficult to obtain owing to the absence of tools for selective manipulation of oscillations during early development. We established a protocol that combines optogenetics with electrophysiological recordings from neonatal mice in vivo to elucidate the substrate of early network oscillations in the prefrontal cortex...
February 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28193169/eeg-correlates-of-working-memory-performance-in-females
#6
Yuri G Pavlov, Boris Kotchoubey
BACKGROUND: The study investigates oscillatory brain activity during working memory (WM) tasks. The tasks employed varied in two dimensions. First, they differed in complexity from average to highly demanding. Second, we used two types of tasks, which required either only retention of stimulus set or retention and manipulation of the content. We expected to reveal EEG correlates of temporary storage and central executive components of WM and to assess their contribution to individual differences...
February 13, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28192762/neural-mass-models-describing-possible-origin-of-the-excessive-beta-oscillations-correlated-with-parkinsonian-state
#7
Chen Liu, Yulin Zhu, Fei Liu, Jiang Wang, Huiyan Li, Bin Deng, Chris Fietkiewicz, Kenneth A Loparo
In Parkinson's disease, the enhanced beta rhythm is closely associated with akinesia/bradykinesia and rigidity. An increase in beta oscillations (12-35 Hz) within the basal ganglia (BG) nuclei does not proliferate throughout the cortico-basal ganglia loop in uniform fashion; rather it can be subdivided into two distinct frequency bands, i.e. the lower beta (12-20 Hz) and upper beta (21-35 Hz). A computational model of the excitatory and inhibitory neural network that focuses on the population properties is proposed to explore the mechanism underlying the pathological beta oscillations...
January 30, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28179556/distinct-oscillatory-frequencies-underlie-excitability-of-human-occipital-and-parietal-cortex
#8
Jason Samaha, Olivia Gosseries, Bradley R Postle
Transcranial magnetic stimulation (TMS) of human occipital and posterior parietal cortex can give rise to visual sensations called phosphenes. We used near-threshold TMS with concurrent electroencephalography (EEG) recordings to measure how oscillatory brain dynamics covary, on single trials, with the perception of phosphenes following occipital and parietal TMS. Prestimulus power and phase, predominantly in the alpha band (8-13 Hz), predicted occipital TMS phosphenes, whereas higher frequency beta-band (13-20 Hz) power (but not phase) predicted parietal TMS phosphenes...
February 8, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28179479/impaired-auditory-to-motor-entrainment-in-parkinson-s-disease
#9
Erik S Te Woerd, Robert Oostenveld, Floris Pieter De Lange, Peter Praamstra
Several electrophysiological studies suggest that PD patients have a reduced tendency to entrain to regular environmental patterns. Here we investigate whether this reduced entrainment concerns a generalized deficit or is confined to movement-related activity, leaving sensory entrainment intact. Magnetoencephalography (MEG) was recorded during a rhythmic auditory target detection task in 14 PD patients and 14 control subjects. Participants were instructed to press a button when hearing a target tone amidst an isochronous sequence of standard tones...
February 8, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28161453/rhythms-dysregulation-a-new-perspective-for-understanding-ptsd
#10
Jacques Dayan, Géraldine Rauchs, Bérengère Guillery-Girard
Post-traumatic stress disorder (PTSD) is a complex syndrome that may occur after exposure to one or more traumatic events. It associates physiological, emotional, and cognitive changes Brain and hormonal modifications contribute to some impairments in learning, memory, and emotion regulation. Some of these biological dysfunctions may be analyzed in terms of rhythms dysregulation that would be expressed through endocrine rhythmicity, sleep organization, and temporal synchrony in brain activity. In the first part of this article, we report studies on endocrine rhythmicity revealing that some rhythms abnormalities are frequently observed, although not constantly, for both cortisol and sympathetic nervous system (SNS) activity...
February 1, 2017: Journal of Physiology, Paris
https://www.readbyqxmd.com/read/28154537/odor-induced-neuronal-rhythms-in-the-olfactory-bulb-are-profoundly-modified-in-ob-ob-obese-mice
#11
Yan Chelminski, Christophe Magnan, Serge H Luquet, Amandine Everard, Nicolas Meunier, Hirac Gurden, Claire Martin
Leptin, the product of the Ob(Lep) gene, is a peptide hormone that plays a major role in maintaining the balance between food intake and energy expenditure. In the brain, leptin receptors are expressed by hypothalamic cells but also in the olfactory bulb, the first central structure coding for odors, suggesting a precise function of this hormone in odor-evoked activities. Although olfaction plays a key role in feeding behavior, the ability of the olfactory bulb to integrate the energy-related signal leptin is still missing...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28121174/the-role-of-beta-adrenergic-receptors-in-the-regulation-of-circadian-intraocular-pressure-rhythm-in-mice
#12
Shunsuke Tsuchiya, Tomomi Higashide, Kazunori Toida, Kazuhisa Sugiyama
PURPOSE: To investigate whether the elimination of β1- and β2-adrenergic receptors alters the diurnal intraocular pressure (IOP) rhythm in mice. MATERIALS AND METHODS: β1-/β2-adrenergic receptor double-knockout and C57BL/6J mice were anesthetized intraperitoneally, with their IOPs measured via microneedle method. After entrainment to a 12-h light-dark (LD) cycle (light phase 6:00-18:00), IOPs were measured every 3 h from 9:00 to 24:00 (group 1, β1-/β2-adrenergic receptor double-knockout mice, n = 11; C57BL/6J, n = 15)...
January 25, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28105938/the-influence-of-pro-longevity-gene-gclc-overexpression-on-the-age-dependent-changes-in-drosophila-transcriptome-and-biological-functions
#13
Alexey Moskalev, Mikhail Shaposhnikov, Ekaterina Proshkina, Alexey Belyi, Alexander Fedintsev, Svetlana Zhikrivetskaya, Zulfiya Guvatova, Asiya Sadritdinova, Anastasia Snezhkina, George Krasnov, Anna Kudryavtseva
BACKGROUND: Transcriptional changes that contribute to the organism's longevity and prevent the age-dependent decline of biological functions are not well understood. Here, we overexpressed pro-longevity gene encoding glutamate-cysteine ligase catalytic subunit (Gclc) and analyzed age-dependent changes in transcriptome that associated with the longevity, stress resistance, locomotor activity, circadian rhythmicity, and fertility. RESULTS: Here we reproduced the life extension effect of neuronal overexpression of the Gclc gene and investigated its influence on the age-depended dynamics of transcriptome and biological functions such as fecundity, spontaneous locomotor activity and circadian rhythmicity, as well as on the resistance to oxidative, proteotoxic and osmotic stresses...
December 28, 2016: BMC Genomics
https://www.readbyqxmd.com/read/28072877/motor-cortex-theta-and-gamma-architecture-in-young-adult-appsweps1de9-alzheimer-mice
#14
Anna Papazoglou, Julien Soos, Andreas Lundt, Carola Wormuth, Varun Raj Ginde, Ralf Müller, Christina Henseler, Karl Broich, Kan Xie, Britta Haenisch, Dan Ehninger, Marco Weiergräber
Alzheimer's disease (AD) is a multifactorial disorder leading to progressive memory loss and eventually death. In this study, an APPswePS1dE9 AD mouse model has been analyzed for motor cortex theta, beta and gamma frequency alterations using computerized 3D stereotaxic electrode positioning and implantable video-EEG radiotelemetry to perform long-term M1 recordings from both genders considering age, circadian rhythm and activity status of experimental animals. We previously demonstrated that APPswePS1dE9 mice exibit complex alterations in hippocampal frequency power and another recent investigation reported a global increase of alpha, beta and gamma power in APPswePS1dE9 in females of 16-17 weeks of age...
2017: PloS One
https://www.readbyqxmd.com/read/28067203/long-term-prognostic-impact-of-left-atrial-volumes-and-emptying-fraction-in-a-community-based-cohort
#15
Pär Hedberg, Jonas Selmeryd, Jerzy Leppert, Egil Henriksen
OBJECTIVE: We hypothesised that left atrial emptying fraction (LAEF) would predict long-term cardiovascular outcome in the general population and better so than left atrial (LA) volumes. METHODS: A community-based sample (n=740) in sinus rhythm prospectively underwent clinical evaluation, echocardiography and blood analyses including N-terminal pro B-type natriuretic peptide (NTproBNP). The LA maximum (LAVmax) and minimum volumes (LAVmin) were indexed to body surface area (LAVImax and LAVImin, respectively)...
November 9, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28039987/a-neural-mass-model-of-basal-ganglia-nuclei-simulates-pathological-beta-rhythm-in-parkinson-s-disease
#16
Fei Liu, Jiang Wang, Chen Liu, Huiyan Li, Bin Deng, Chris Fietkiewicz, Kenneth A Loparo
An increase in beta oscillations within the basal ganglia nuclei has been shown to be associated with movement disorder, such as Parkinson's disease. The motor cortex and an excitatory-inhibitory neuronal network composed of the subthalamic nucleus (STN) and the external globus pallidus (GPe) are thought to play an important role in the generation of these oscillations. In this paper, we propose a neuron mass model of the basal ganglia on the population level that reproduces the Parkinsonian oscillations in a reciprocal excitatory-inhibitory network...
December 2016: Chaos
https://www.readbyqxmd.com/read/28012089/orexin-and-alzheimer-s-disease
#17
Claudio Liguori
Alzheimer's disease (AD) is the most frequent age-related dementia. It prevalently causes cognitive decline, although it is frequently associated with secondary behavioral disturbances. AD neurodegeneration characteristically produces a remarkable destruction of the sleep-wake cycle, with diurnal napping, nighttime arousals, sleep fragmentation, and REM sleep impairment. It was recently hypothesized that the orexinergic system was involved in AD pathology. Accordingly, recent papers showed the association between orexinergic neurotransmission dysfunction, sleep impairment, and cognitive decline in AD...
December 24, 2016: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/27984253/does-heart-rate-really-matter-to-patients-with-heart-failure
#18
Robert J H Miller, Jonathan G Howlett
PURPOSE OF REVIEW: Measurement of heart rate (HR) and rhythm is used to identify patients at increased risk of disease progression, guide selection of treatments and gauge response to therapy. RECENT FINDINGS: Lowering HR with a pure HR lowering agent (ivabradine) in heart failure with reduced ejection fraction (HFrEF) and sinus rate more than 70 beats/min despite beta blockade has been shown to improve outcomes. Additionally, coadministration of ivabradine and beta blockade may enhance symptoms and HR control...
March 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/27981356/chronomedicine-and-type-2-diabetes-shining-some-light-on-melatonin
#19
REVIEW
Andrew C Forrestel, Susanne U Miedlich, Michael Yurcheshen, Steven D Wittlin, Michael T Sellix
In mammals, the circadian timing system drives rhythms of physiology and behaviour, including the daily rhythms of feeding and activity. The timing system coordinates temporal variation in the biochemical landscape with changes in nutrient intake in order to optimise energy balance and maintain metabolic homeostasis. Circadian disruption (e.g. as a result of shift work or jet lag) can disturb this continuity and increase the risk of cardiometabolic disease. Obesity and metabolic disease can also disturb the timing and amplitude of the clock in multiple organ systems, further exacerbating disease progression...
December 16, 2016: Diabetologia
https://www.readbyqxmd.com/read/27974045/cumulative-subgroup-analysis-to-reduce-waste-in-clinical-research-for-individualised-medicine
#20
Fujian Song, Max O Bachmann
BACKGROUND: Although subgroup analyses in clinical trials may provide evidence for individualised medicine, their conduct and interpretation remain controversial. METHODS: Subgroup effect can be defined as the difference in treatment effect across patient subgroups. Cumulative subgroup analysis refers to a series of repeated pooling of subgroup effects after adding data from each of related trials chronologically, to investigate the accumulating evidence for subgroup effects...
December 15, 2016: BMC Medicine
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