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https://www.readbyqxmd.com/read/29783682/heat-shock-gene-inactivation-and-protein-aggregation-with-links-to-chronic-diseases
#1
Ian James Martins
The heat shock response involved in protein misfolding is linked to the formation of toxic immunogenic proteins with heat shock proteins (HSP) as regulators of amyloid beta aggregation. The defective amyloid beta trafficking between different intracellular compartments is now relevant to HSPs and autoimmunity. Overnutrition, temperature dysregulation, and stress repress the heat shock gene Sirtuin 1 with the induction of HSP regulated amyloid beta aggregation involved in the autoimmune response. Defective circadian rhythm alterations are connected to inactivation of the peripheral sink amyloid beta clearance pathway and related to insulin resistance, protein aggregation, and autoimmune disease in non-alcoholic fatty liver disease (NAFLD) and various neurodegenerative diseases such as Alzheimer's disease...
May 18, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29765476/developmental-trends-of-theta-beta-interelectrode-power-correlation-during-resting-state-in-normal-children
#2
Ernesto Buiza, Elena I Rodríguez-Martínez, Catarina I Barriga-Paulino, Antonio Arjona, Carlos M Gómez
The possibility that power-to-power (theta-beta) frequency coupling increases during development was analyzed. Three minutes of spontaneous EEG in an open eyes condition were recorded in a sample of 160 subjects ranging from 6 to 26 years old. Theta (4-7 Hz) and beta band (15-20 Hz) power was calculated in a trial-by-trial basis. Inter-electrode power correlations (IPC) were computed in each subject as the correlation between the power of two frequency bands recorded in two electrodes. An increase in theta-beta IPC with age was obtained...
June 2018: Cognitive Neurodynamics
https://www.readbyqxmd.com/read/29762768/emergence-of-mature-cortical-activity-in-wakefulness-and-sleep-in-healthy-pre-term-and-full-term-infants
#3
Kimberley Whitehead, Pureza Laudiano-Dray, Judith Meek, Lorenzo Fabrizi
Study Objectives: Cortical activity patterns develop rapidly over the equivalent of the last trimester of gestation, in parallel with the establishment of sleep architecture. However, the emergence of mature cortical activity in wakefulness compared to sleep states in healthy pre-term infants is poorly understood. Methods: To investigate whether cortical activity has a different developmental profile in each sleep-wake state, we recorded 11-channels EEG, EOG and respiratory movement for one hour from 115 infants 34-43 weeks corrected age, with 0...
May 14, 2018: Sleep
https://www.readbyqxmd.com/read/29755291/transcription-factor-co-expression-networks-of-adipose-rna-seq-data-reveal-regulatory-mechanisms-of-obesity
#4
Ruta Skinkyte-Juskiene, Lisette J A Kogelman, Haja N Kadarmideen
Background: Transcription Factors (TFs) control actuation of genes in the genome and are key mediators of complex processes such as obesity. Master Regulators (MRs) are the genes at the top of a regulation hierarchy which regulate other genes. Objective: To elucidate clusters of highly co-expressed TFs (modules), involved pathways, highly inter-connected TFs (hub-TFs) and MRs leading to obesity and leanness, using porcine model for human obesity. Methods: We identified 817 expressed TFs in RNA-Sequencing dataset representing extreme degrees of obesity (DO; lean, obese)...
May 2018: Current Genomics
https://www.readbyqxmd.com/read/29754666/a-genotype-directed-comparative-effectiveness-trial-of-bucindolol-and-metoprolol-succinate-for-prevention-of-symptomatic-atrial-fibrillation-atrial-flutter-in-patients-with-heart-failure-rationale-and-design-of-the-genetic-af-trial
#5
Jonathan P Piccini, Stuart J Connolly, William T Abraham, Jeff S Healey, Benjamin A Steinberg, Hussein R Al-Khalidi, Patricia Dignacco, Dirk J van Veldhuisen, William H Sauer, Michel White, Stephen B Wilton, Inder S Anand, Christopher Dufton, Debra A Marshall, Ryan G Aleong, Gordon W Davis, Richard L Clark, Laura L Emery, Michael R Bristow
BACKGROUND: Few therapies are available for the safe and effective treatment of atrial fibrillation (AF) in patients with heart failure. Bucindolol is a non-selective beta-blocker with mild vasodilator activity previously found to have accentuated antiarrhythmic effects and increased efficacy for preventing heart failure events in patients homozygous for the major allele of the ADRB1 Arg389Gly polymorphism (ADRB1 Arg389Arg genotype). The safety and efficacy of bucindolol for the prevention of AF or atrial flutter (AFL) in these patients has not been proven in randomized trials...
May 2018: American Heart Journal
https://www.readbyqxmd.com/read/29752227/a-novel-signal-modeling-approach-for-classification-of-seizure-and-seizure-free-eeg-signals
#6
Anubha Gupta, Pushpendra Singh, Mandar Karlekar
This paper presents a signal modeling-based new methodology of automatic seizure detection in EEG signals. The proposed method consists of three stages. First, a multirate filterbank structure is proposed that is constructed using the basis vectors of discrete cosine transform. The proposed filterbank decomposes EEG signals into its respective brain rhythms: delta, theta, alpha, beta, and gamma. Second, these brain rhythms are statistically modeled with the class of self-similar Gaussian random processes, namely, fractional Brownian motion and fractional Gaussian noises...
May 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29740300/spectral-spatial-differentiation-of-brain-activity-during-mental-imagery-of-improvisational-music-performance-using-meg
#7
Jared Boasen, Yuya Takeshita, Shinya Kuriki, Koichi Yokosawa
Group musical improvisation is thought to be akin to conversation, and therapeutically has been shown to be effective at improving communicativeness, sociability, creative expression, and overall psychological health. To understand these therapeutic effects, clarifying the nature of brain activity during improvisational cognition is important. Some insight regarding brain activity during improvisational music cognition has been gained via functional magnetic resonance imaging (fMRI) and electroencephalography (EEG)...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29737585/no-changes-in-parieto-occipital-alpha-during-neural-phase-locking-to-visual-quasi-periodic-theta-alpha-and-beta-band-stimulation
#8
Christian Keitel, Christopher S Y Benwell, Gregor Thut, Joachim Gross
Recent studies have probed the role of the parieto-occipital alpha rhythm (8 - 12 Hz) in human visual perception through attempts to drive its neural generators. To that end, paradigms have used high-intensity strictly-periodic visual stimulation that created strong predictions about future stimulus occurrences and repeatedly demonstrated perceptual consequences in line with an entrainment of parieto-occipital alpha. Our study, in turn, examined the case of alpha entrainment by non-predictive low-intensity quasi-periodic visual stimulation within theta- (4 - 7 Hz), alpha- (8 - 13 Hz) and beta (14 - 20 Hz) frequency bands, i...
May 8, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29736384/a-technology-developed-from-concept-of-acupuncture-and-meridian-system-the-clinical-effect-of-bioceramic-resonance-on-psychological-related-sleep-disturbance-with-findings-on-questionnaire-eeg-and-fmri
#9
Lei Zhang, Paul Chan, Zhong Min Liu, Yi Li Tseng, C Will Chen, Ming Tse Lin, Wing P Chan, Ting-Kai Leung
Under the concept of meridian channels that belongs to traditional Chinese medicine, BIOCERAMIC Resonance (BR) has already been applied to many clinical medical research projects with functions mimicking of traditional acupuncture. Forty-five patients were recruited with chronic sleep disorders; 36 patients were given, applied to the device with BIOCERAMIC material and sound rhythm on chest skin surface; 9 patients were included as controls. All study participants completed a sleep pattern and quality of life questionnaire (assessment on psychological and physical causes of sleep disturbances), which was repeated before, during and after treatment...
April 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29735880/-the-effects-of-neurofeedback-training-on-physical-psychoemotional-stress-response-and-self-regulation-for-late-adolescence-a-non-randomized-trial
#10
Moon Ji Choi, Wan Ju Park
PURPOSE: The aim of this study was to analyze the effects of neurofeedback training for reducing stress and enhancing self-regulation in late adolescence to identify the possibility of use for nursing intervention. METHODS: A nonequivalent control group pre-post quasi-experimental design was used. Participants were 78 late adolescents assigned to the experimental group (n=39) that received the neurofeedback training and the control group (n=39). Data were collected on heart rate variability (HRV) and skin conductance level (SCL) to assess stress-biomarker response...
April 2018: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/29723683/beyond-the-length-and-look-of-repolarization-defining-the-non-qtc-electrocardiographic-profiles-of-patients-with-congenital-long-qt-syndrome
#11
Conor M Lane, J Martijn Bos, Ram K Rohatgi, Michael J Ackerman
BACKGROUND: Little is known about the spectrum and prevalence of ECG features beyond the length and morphology of repolarization in patients with congenital long QT syndrome (LQTS). OBJECTIVE: To characterize the full ECG phenotype of LQTS patients and evaluate differences by age and LQTS genotype. METHODS: Retrospective review of 943 patients with LQTS (57% female, median age 25 years; IQR 9 - 34 years) was performed. Comprehensive analysis of their initial evaluation ECG was performed using definitions outlined in Heart Rhythm Society guidelines...
April 30, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29705848/how-to-monitor-the-neuroimmune-biological-response-in-patients-affected-by-immune-alteration-related-systemic-diseases
#12
Paolo Lissoni, Franco Rovelli, Luigi Vigorè, Giusy Messina, Arianna Lissoni, Giorgio Porro, Giuseppe Di Fede
The clinical management of patients affected by systemic diseases, including cancer and autoimmune diseases, is generally founded on the evaluation of the only markers related to the single disease rather than the biological immuno-inflammatory response of patients, despite the fundamental role of cytokine network in the pathogenesis of cancer and autoimmunity is well known. Cancer progression has appeared to be associated with a progressive decline in the blood levels of the main antitumor cytokines, including IL-2 and IL-12, in association with an increase in those of inflammatory cytokines, including IL-6, TNF-alpha, and IL-1-beta, and immunosuppressive cytokines, namely TGF-beta and IL-10...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29680274/suppression-of-eeg-mu-rhythm-during-action-observation-corresponds-with-subsequent-changes-in-behavior
#13
Nadav Aridan, Ori Ossmy, Batel Buaron, Daniel Reznik, Roy Mukamel
Movement is intrinsically linked to perception such that observing an action induces in the observer behavioral changes during execution of similar actions. Electroencephalogram (EEG) studies have revealed that at the group level, action observation suppresses oscillatory power in mu (8-12Hz) and beta (15-25Hz) bands over the sensorimotor cortex - a phenomenon associated with increased excitability of cortical neurons. However, it is unclear whether differences in suppression level across individuals is linked with individual differences in subsequent behavioral changes...
April 19, 2018: Brain Research
https://www.readbyqxmd.com/read/29678369/impaired-corticomuscular-and-interhemispheric-cortical-beta-oscillation-coupling-in-amyotrophic-lateral-sclerosis
#14
Malcolm Proudfoot, Freek van Ede, Andrew Quinn, Giles L Colclough, Joanne Wuu, Kevin Talbot, Michael Benatar, Mark W Woolrich, Anna C Nobre, Martin R Turner
OBJECTIVES: The neural activity of the primary motor cortex is variably synchronised with contralateral peripheral electromyographic signals, which is thought to facilitate long-range communication through the motor system. Such corticomuscular coherence (CMC) is typically observed in the beta-band (15-30 Hz) range during steady force production. We aimed to measure pathological alteration to CMC resulting from ALS. METHODS: CMC was appraised during a forearm grip task in 17 ALS patients contrasted against age-matched healthy controls...
April 6, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29670516/the-effects-of-fluency-enhancing-conditions-on-sensorimotor-control-of-speech-in-typically-fluent-speakers-an-eeg-mu-rhythm-study
#15
Tiffani Kittilstved, Kevin J Reilly, Ashley W Harkrider, Devin Casenhiser, David Thornton, David E Jenson, Tricia Hedinger, Andrew L Bowers, Tim Saltuklaroglu
Objective : To determine whether changes in sensorimotor control resulting from speaking conditions that induce fluency in people who stutter (PWS) can be measured using electroencephalographic (EEG) mu rhythms in neurotypical speakers. Methods : Non-stuttering (NS) adults spoke in one control condition (solo speaking) and four experimental conditions (choral speech, delayed auditory feedback (DAF), prolonged speech and pseudostuttering). Independent component analysis (ICA) was used to identify sensorimotor μ components from EEG recordings...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29666633/the-eeg-activity-during-binocular-depth-perception-of-2d-images
#16
Marsel Fazlyyyakhmatov, Nataly Zwezdochkina, Vladimir Antipov
The central brain functions underlying a stereoscopic vision were a subject of numerous studies investigating the cortical activity during binocular perception of depth. However, the stereo vision is less explored as a function promoting the cognitive processes of the brain. In this work, we investigated a cortical activity during the cognitive task consisting of binocular viewing of a false image which is observed when the eyes are refocused out of the random-dot stereogram plane (3D phenomenon). The power of cortical activity before and after the onset of the false image perception was assessed using the scull EEG recording...
2018: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/29624593/work-routines-moderate-the-association-between-eveningness-and-poor-psychological-well-being
#17
Felipe Gutiérrez Carvalho, Camila Morelatto de Souza, Maria Paz Loayza Hidalgo
Well-being is a useful screening method for the detection of mood disorders. Evidence associating psychological well-being with sleep-wake patterns exists, as well as associations with sleep-wake patterns, work-related parameters, and perceived self-efficacy. Despite the growing research regarding the relationship between these factors and mental health, there are few studies that analyze them together. OBJECTIVE: To investigate if the association between sleep-wake patterns and psychological well-being is mediated or moderated by perceived self-efficacy, work flexibility and work routines...
2018: PloS One
https://www.readbyqxmd.com/read/29622423/optimization-of-heart-rate-lowering-therapy-in-hospitalized-patients-with-heart-failure-insights-from-the-optimize-heart-failure-care-program
#18
Yuri M Lopatin, Martin R Cowie, Anna A Grebennikova, Hamayak S Sisakian, Zurab M Pagava, Hamlet G Hayrapetyan, Timur A Abdullaev, Leonid G Voronkov, Anna I Chesnikova, Vira I Tseluyko, Ekaterina I Tarlovskaya, Gülnaz M Dadashova, Salim F Berkinbaev, Maria G Glezer, Natalia A Koziolova, Amina G Rakisheva, Zviad V Kipiani, Alena K Kurlyanskaya
BACKGROUND: Hospitalization is an opportunity to optimize heart failure (HF) therapy. As optimal treatment for hospitalized HF patients in sinus rhythm with heart rate≥70bpm is unclear, we investigated the impact of combined beta-blocker (BB) and ivabradine versus BBs alone on short and longer term mortality and rehospitalization. METHODS AND RESULTS: A retrospective analysis was performed on 370 hospitalized HF patients with heart rate≥70bpm (150 BB+ivabradine, 220 BB alone) in the Optimize Heart Failure Care Program in Armenia, Azerbaijan, Belarus, Georgia, Kazakhstan, Russia, Ukraine, and Uzbekistan, from October 2015 to April 2016...
June 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29615853/exploring-eeg-features-in-cross-subject-emotion-recognition
#19
Xiang Li, Dawei Song, Peng Zhang, Yazhou Zhang, Yuexian Hou, Bin Hu
Recognizing cross-subject emotions based on brain imaging data, e.g., EEG, has always been difficult due to the poor generalizability of features across subjects. Thus, systematically exploring the ability of different EEG features to identify emotional information across subjects is crucial. Prior related work has explored this question based only on one or two kinds of features, and different findings and conclusions have been presented. In this work, we aim at a more comprehensive investigation on this question with a wider range of feature types, including 18 kinds of linear and non-linear EEG features...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29615848/decoding-imagined-3d-hand-movement-trajectories-from-eeg-evidence-to-support-the-use-of-mu-beta-and-low-gamma-oscillations
#20
Attila Korik, Ronen Sosnik, Nazmul Siddique, Damien Coyle
Objective: To date, motion trajectory prediction (MTP) of a limb from non-invasive electroencephalography (EEG) has relied, primarily, on band-pass filtered samples of EEG potentials i.e., the potential time-series model. Most MTP studies involve decoding 2D and 3D arm movements i.e., executed arm movements. Decoding of observed or imagined 3D movements has been demonstrated with limited success and only reported in a few studies. MTP studies normally use EEG potentials filtered in the low delta (~1 Hz) band for reconstructing the trajectory of an executed or an imagined/observed movement...
2018: Frontiers in Neuroscience
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