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Inflammatory bowel

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https://www.readbyqxmd.com/read/29793168/olive-oil-polyphenols-reduce-oxysterols-induced-redox-imbalance-and-pro-inflammatory-response-in-intestinal-cells
#1
Gessica Serra, Alessandra Incani, Gabriele Serreli, Laura Porru, M Paola Melis, Carlo I G Tuberoso, Daniela Rossin, Fiorella Biasi, Monica Deiana
Dietary habits may strongly influence intestinal homeostasis. Oxysterols, the oxidized products of cholesterol present in cholesterol-containing foodstuffs, have been shown to exert pro-oxidant and pro-inflammatory effects, altering intestinal epithelial layer and thus contributing to the pathogenesis of human inflammatory bowel diseases and colon cancer. Extra virgin olive oil polyphenols possess antioxidant and anti-inflammatory properties, and concentrate in the intestinal lumen, where may help in preventing intestinal diseases...
May 16, 2018: Redox Biology
https://www.readbyqxmd.com/read/29792883/plasma-n-glycan-signatures-associate-with-features-of-inflammatory-bowel-diseases
#2
Florent Clerc, Mislav Novokmet, Viktoria Dotz, Karli R Reiding, Noortje de Haan, Guinevere S M Kammeijer, Hans Dalebout, Marco R Bladergroen, Frano Vukovic, Erdmann Rapp, Stephan R Targan, Gildardo Barron, Natalia Manetti, Anna Latiano, Dermot P B McGovern, Vito Annese, Gordan Lauc, Manfred Wuhrer
BACKGROUND & AIMS: Biomarkers are needed for early detection of Crohn's disease (CD) and ulcerative colitis (UC) or to predict patient outcomes. Glycosylation is a common and complex post-translational modification of proteins that affects their structure and activity. We compared plasma N-glycosylation profiles between patients with CD or UC and healthy individuals (controls). METHODS: We analyzed the total plasma N-glycomes of 2635 patients with inflammatory bowel diseases and 996 controls by mass spectrometry with a linkage-specific sialic acid derivatization technique...
May 21, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29792084/lethal-disseminated-tuberculosis-in-patients-under-biological-treatment-two-clinical-cases-and-a-short-review
#3
Elena Dantes, Doina Ecaterina Tofolean, Ariadna Petronela Fildan, Liviu Craciun, Elena Dumea, Ioan Tiberiu Tofolean, Laura Mazilu
Tumour necrosis factor (TNF)-α inhibitors are highly used in Romania for the treatment of autoimmune disorders, such as rheumatoid arthritis (RA), psoriasis, inflammatory bowel diseases, and ankylosing spondylitis. Biological therapy using TNF-α inhibitors is very effective but is associated with an increased risk of opportunistic infections, including active tuberculosis. Here, two cases are presented of patients with RA and psoriasis under biological therapy who developed very aggressive forms of disseminated tuberculosis, with a rapid progression to death...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29791168/impact-of-surgery-on-quality-of-life-in-crohn%C3%A2-s-disease-patients-final-results-of-czech-cohort
#4
Lumír Kunovský, Ladislav Mitas, Filip Marek, Jiri Dolina, Karolina Poredska, Lenka Kucerova, Klara Benesova, Zdeněk Kala
INTRODUCTION: Crohns disease (CD) belongs to chronic diseases that highly affect the patient´s quality of life (QoL). The effect of the disease and impairment of QoL in CD patients is already known. The aim was to assess how surgical treatment influences the patients QoL and determine factors that can affect postoperative QoL. METHODS AND PATIENTS: We compared the QoL before and after surgery in patients who had undergone a bowel resection at our department due to CD between 2010-2016...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29791048/long-term-course-of-inflammatory-bowel-disease-after-the-great-east-japan-earthquake
#5
Teruko Miyazawa, Hisashi Shiga, Yoshitaka Kinouchi, Seiichi Takahashi, Gen Tominaga, Hiroki Takahashi, Sho Takagi, Nobuya Obana, Tatsuya Kikuchi, Shinya Omori, Yuichirou Sato, Shuichiro Takahashi, Ken Umemura, Katsuya Endo, Yoichi Kakuta, Masaki Matsuura, Tomoya Kimura, Masatake Kuroha, Tooru Shimosegawa
BACKGROUND AND AIM: This study analyzed inflammatory bowel disease activity for two years after the Great East Japan Earthquake. METHODS: We compared the relapse rates of patients with ulcerative colitis or Crohn's disease 1 and 2 years after the earthquake with rates immediately after the earthquake. To evaluate continuous disease courses, we also performed multivariate time-to-event analyses from the time of the earthquake to the onset of additional treatments...
May 23, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29790793/increased-arterial-stiffness-similar-findings-in-patients-with-inflammatory-bowel-disease-without-prior-hypertension-or-diabetes-and-in-patients-with-well-controlled-hypertension
#6
Radovan Prijić, Vedran Premužić, Marko Brinar, Željko Krznarić, Bojan Jelaković, Silvija Čuković-Čavka
PURPOSE: Chronic inflammatory diseases are related with earlier onset of atherosclerosis. We hypothesized that inflammatory bowel disease patients with chronic, systemic inflammation have an increased arterial stiffness associated with the disease duration. Also, we wanted to compare arterial stiffness markers between inflammatory bowel disease and well-controlled hypertension patients. MATERIALS AND METHODS: A total of 89 inflammatory bowel disease patients (60 patients with Crohn's disease and 29 patients with ulcerative colitis, age range 20-64 years) without history of arterial hypertension or diabetes were enrolled and age matched with a control group of patients (73 patients, age range 25-69 years, 41 (56...
May 23, 2018: Blood Pressure
https://www.readbyqxmd.com/read/29790024/mechanism-of-activation-of-enteric-nociceptive-neurons-via-interaction-of-tlr4-and-trpv1-receptors
#7
L V Filippova, A V Fedorova, A D Nozdrachev
Evidence obtained by immunohistochemical double labeling and confocal laser scanning microscopy suggests that capsaicin, a ligand of the TRPV1 nociceptive vanilloid receptor, increases the number of TLR4-positive neurons in the rat colon myenteric plexus. In colitis caused by trinitrobenzene sulfonate, an increase in TRPV1 expression was more significant in both plexuses. Specific inhibitor of the TLR4 (C34) pattern-recognition receptor reduces TRPV1 expression in enteric neurons of both intact rats and rats with induced acute colitis...
March 2018: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://www.readbyqxmd.com/read/29789682/the-role-of-diet-in-the-aetiopathogenesis-of-inflammatory-bowel-disease
#8
REVIEW
Hamed Khalili, Simon S M Chan, Paul Lochhead, Ashwin N Ananthakrishnan, Andrew R Hart, Andrew T Chan
Crohn's disease and ulcerative colitis, collectively known as IBD, are chronic inflammatory disorders of the gastrointestinal tract. Although the aetiopathogenesis of IBD is largely unknown, it is widely thought that diet has a crucial role in the development and progression of IBD. Indeed, epidemiological and genetic association studies have identified a number of promising dietary and genetic risk factors for IBD. These preliminary studies have led to major interest in investigating the complex interaction between diet, host genetics, the gut microbiota and immune function in the pathogenesis of IBD...
May 22, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29789648/dalm-rest-in-peace-a-pathologist-s-perspective-on-dysplasia-in-inflammatory-bowel-disease-in-the-post-dalm-era
#9
REVIEW
Kenrry Chiu, Robert H Riddell, David F Schaeffer
There are few abbreviations in surgical pathology that are associated with as much immediate recognition, frustration, and confusion as DALM (dysplasia-associated lesion or mass). DALM is used to describe endoscopically visible dysplastic lesions in the surveillance of patients with inflammatory bowel disease. However, the diagnosis of DALM has been complicated by the inconsistent criteria and use of terminology for describing dysplasia in inflammatory bowel disease, and a tendency to relate DALM with the need for colectomy...
May 22, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29789376/optogenetic-activation-of-colon-epithelium-of-the-mouse-produces-high-frequency-bursting-in-extrinsic-colon-afferents-and-engages-visceromotor-responses
#10
Payal A Makadia, Sarah A Najjar, Jami L Saloman, Peter Adelman, Bin Feng, Joseph F Margiotta, Kathryn M Albers, Brian M Davis
Epithelial cells of the colon provide a vital interface between the internal environment (lumen of the colon) and colon parenchyma. To examine epithelial-neuronal signaling at this interface, we analyzed mice in which channelrhodopsin (ChR2) was targeted to either TRPV1-positive afferents or to villin expressing colon epithelial cells. Expression of a ChR2-EYFP fusion protein was directed to either primary sensory neurons or to colon epithelial cells by crossing Ai32 mice with TRPV1-Cre or villin-Cre mice, respectively...
May 22, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29788876/exploiting-significance-of-physical-exercise-in-prevention-of-gastrointestinal-disorders
#11
Jan Bilski, Agnieszka Mazur-Bialy, Marcin Magierowski, Slawomir Kwiecien, Dagmara Wojcik, Agata Ptak-Belowska, Marcin Surmiak, Aneta Targosz, Katarzyna Magierowska, Tomasz Brzozowski
BACKGROUND: Physical activity can be involved in the prevention of gastrointestinal (GI)-tract diseases, however, the results regarding the volume and the intensity of exercise considered as beneficial for protection of gastrointestinal organs are conflicting. AIMS AND METHODS: The main objective of this review is to provide a comprehensive and updated overview on the beneficial and harmful effects of physical activity on the gastrointestinal tract. We attempted to discuss recent evidence regarding the association between different modes and intensity levels of exercise and physiological functions of the gut and gut pathology...
May 21, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29788675/anti-tumor-necrosis-factor-therapy-in-intestinal-beh%C3%A3-et-s-disease
#12
REVIEW
Jihye Park, Jae Hee Cheon
Intestinal Behçet's disease is a rare, immune-mediated chronic intestinal inflammatory disease; therefore, clinical trials to optimize the management and treatment of patients are scarce. Moreover, intestinal Behçet's disease is difficult to treat and often requires surgery because of the failure of conventional medical treatment. Administration of anti-tumor necrosis factor α, a potential therapeutic strategy, is currently under active clinical investigation, and evidence of its effectiveness for both intestinal Behçet's disease and inflammatory bowel diseases has been accumulating...
May 24, 2018: Gut and Liver
https://www.readbyqxmd.com/read/29788474/umbilical-cord-blood-transplantation-corrects-very-early-onset-inflammatory-bowel-disease-in-chinese-patients-with-il10ra-associated-immune-deficiency
#13
Kaiyue Peng, Xiaowen Qian, Zhiheng Huang, Junping Lu, Yuhuan Wang, Ying Zhou, Huijun Wang, Bingbing Wu, Ying Wang, Lingli Chen, Xiaowen Zhai, Ying Huang
Background: Hematopoietic stem cell transplantation is considered the only curative therapy for very early-onset inflammatory bowel disease with specific immune defects, such as interleukin-10 receptor deficiency. We performed reduced-intensity conditioning before umbilical cord blood transplantation in patients with interleukin-10 receptor-A deficiency. Methods: We enrolled 9 very early-onset inflammatory bowel disease patients with typical manifestations. We diagnosed the patients with interleukin-10 receptor-A deficiency by whole-exome sequencing...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788469/influences-and-impact-of-anxiety-and-depression-in-the-setting-of-inflammatory-bowel-disease
#14
Seyedehsan Navabi, Venkata Subhash Gorrepati, Sanjay Yadav, Jaykrishna Chintanaboina, Sarah Maher, Peter Demuth, Benjamin Stern, August Stuart, Andrew Tinsley, Kofi Clarke, Emmanuelle D Williams, Matthew D Coates
Background: Individuals with inflammatory bowel disease (IBD) are at increased risk of developing anxiety or depression (A&D). Crohn's disease (CD) and ulcerative colitis (UC) with comorbid A&D are both more challenging to manage. IBD providers need to better understand the causes and impact of A&D in order to improve care for IBD patients. We sought to identify clinical factors that influence development of A&D and healthcare utilization in IBD. Methods: This is a retrospective analysis using an IBD natural history registry from a single tertiary care referral center...
May 17, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788416/evaluation-of-rapid-vs-standard-infliximab-infusions-in-the-pediatric-population
#15
Nicole A Rozette, Christina M Hellauer, Chephra McKee, Turaj Vazifedan, Christos A Gabriel, James E Dice, Nancy U Yokois
Background: Rapid 1-hour infliximab infusions have been safely implemented in adults, but studies of these rapid infusions in pediatric patients are limited. This study's primary objective was to determine the safety of 1-hour infliximab infusions compared with standard 2- to 3-hour infusions in children with inflammatory bowel disease and other autoimmune disorders. Methods: We conducted an institutional review board-approved prospective study using an unmatched historical control group at a freestanding children's hospital comparing rapid vs standard infusion rates of infliximab and the use of premedications and immunomodulatory agents on the frequency of early and delayed infusion reactions...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788410/differentiation-between-pediatric-irritable-bowel-syndrome-and-inflammatory-bowel-disease-based-on-fecal-scent-proof-of-principle-study
#16
Sofie Bosch, Nora van Gaal, Roy P Zuurbier, James A Covington, Alfian N Wicaksono, Maarten H Biezeveld, Marc A Benninga, Chris J Mulder, Nanne K H de Boer, Tim G J de Meij
Background: The diagnostic work-up of pediatric irritable bowel syndrome (IBS) and functional abdominal pain-not otherwise specified (FAP-NOS) commonly includes invasive tests for discrimination from inflammatory bowel disease (IBD). As this carries a high burden on patients, an ongoing need exists for development of noninvasive diagnostic biomarkers for IBS and FAP-NOS. Several studies have shown microbiota alterations in IBS/FAP, which are considered to be reflected by fecal volatile organic compounds (VOCs)...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788407/deregulation-of-sgk1-in-ulcerative-colitis-a-paradoxical-relationship-between-immune-cells-and-colonic-epithelial-cells
#17
Rocco Spagnuolo, Vincenzo Dattilo, Lucia D'Antona, Cristina Cosco, Rossana Tallerico, Valeria Ventura, Francesco Conforti, Caterina Camastra, Rosellina M Mancina, Giada Catalogna, Vincenzo Cosco, Rodolfo Iuliano, Ennio Carbone, Nicola Perrotti, Rosario Amato, Patrizia Doldo
Background: Inflammatory bowel disease (IBD) is due to the interaction of genetic and environmental factors that trigger an unbalanced immune response ultimately resulting in the peculiar inflammatory reaction. Experimental models of IBD point to a role of T-cell-derived cytokines (Th17) and to SGK1 as mediator of the Th17 switch. We hypothesize that SGK1, a salt inducible kinase, directs lymphocytic behavior and tissue damage. Methods: Eleven controls and 32 ulcerative colitis (UC) patients were randomized according to endoscopic Mayo score...
May 18, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788391/distinct-histopathologic-and-molecular-alterations-in-inflammatory-bowel-disease-associated-intestinal-adenocarcinoma-c-myc-amplification-is-common-and-associated-with-mucinous-signet-ring-cell-differentiation
#18
Douglas J Hartman, David G Binion, Miguel D Regueiro, Caitlyn Miller, Cameron Herbst, Reetesh K Pai
Background: Chronic idiopathic inflammatory bowel disease (IBD) is a significant risk factor for the development of intestinal adenocarcinoma. The underlying molecular alterations in IBD-associated intestinal adenocarcinoma remain largely unknown. Methods: We compared the clinicopathologic and molecular features of 35 patients with 47 IBD-associated intestinal adenocarcinomas with a consecutive series of 451 patients with sporadic colorectal carcinoma identified at our institution and published data on sporadic colorectal carcinoma...
May 17, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788385/systematic-review-and-meta-analysis-vedolizumab-and-postoperative-complications-in-inflammatory-bowel-disease
#19
Diana E Yung, Nir Horesh, Amy L Lightner, Shomron Ben-Horin, Rami Eliakim, Anastasios Koulaouzidis, Uri Kopylov
Background: Several studies have reported the surgical outcomes of inflammatory bowel disease (IBD) patients exposed to vedolizumab (VDZ) preoperatively, with conflicting results. This meta-analysis aims to evaluate the risk of postoperative complications in IBD patients preoperatively exposed to VDZ in comparison with patients exposed to anti-tumor necrosis factor (anti-TNF) treatment or no biologic therapy. Methods: A systematic review with a meta-analysis of the existing literature was conducted...
May 17, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29788383/assessment-of-quality-of-life-in-chinese-patients-with-inflammatory-bowel-disease-and-their-caregivers
#20
Rui Liu, Anliu Tang, Xiaoyan Wang, Shourong Shen
Background: Chronic diseases such as inflammatory bowel disease (IBD) usually affect the psychological status and health-related quality of life (HRQOL) of patients and their caregivers. The aim of this study was to evaluate the level of anxiety, depression, and HRQOL and find the risk factors predictive of HRQOL in IBD patients and their caregivers in a Chinese population. Methods: One hundred four adult patients with IBD, 102 family caregivers, and 99 healthy controls were enrolled...
May 17, 2018: Inflammatory Bowel Diseases
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