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https://www.readbyqxmd.com/read/28735475/antioxidant-and-antibacterial-activities-of-pelargonium-asperum-and-ormenis-mixta-essential-oils-and-their-synergistic-antibacterial-effect
#1
Wessal Ouedrhiri, Mounyr Balouiri, Samira Bouhdid, El Houssaine Harki, Sandrine Moja, Hassane Greche
In this work, the chemical composition, the antioxidant, and the antibacterial activities of two Moroccan essential oils less studied, extracted from Pelargonium asperum and Ormenis mixta, were investigated. According to the gas chromatography coupled to mass spectrometry analysis, citronellol (25.07%), citronellyl ester (10.52%), geraniol (10.46%), and buthyl anthranilate (5.93%) were found to be the major components of P. asperum, while O. mixta was mainly composed of D-germacrene (11.46%), 1,8-cineole (10...
July 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28735049/in-vitro-activity-of-daptomycin-combinations-with-rifampicin-gentamicin-fosfomycin-and-fusidic-acid-against-mrsa-strains
#2
Gulseren Aktas, Sengul Derbentli
OBJECTIVES: Although new antimicrobial agents designed to treat infections with limited therapeutic options have been introduced in the past few years, resistant Gram positive cocci have continued to emerge and spread. Daptomycin is a cyclic lipopeptide antibiotic that has rapid bactericidal activity against broad spectrum of Gram positive bacteria, including methicillin resistant Staphylococcus aureus (MRSA). Antibiotics are sometimes used in combination in an attempt to prevent or delay the in vivo emergence of drug-resistant subpopulations of pathogenic organisms...
July 19, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28733283/osmotic-compounds-enhance-antibiotic-efficacy-against-acinetobacter-baumannii-biofilm-communities
#3
Azeza Falghoush, Haluk Beyenal, Thomas E Besser, Anders Omsland, Douglas R Call
Biofilm-associated infections are a clinical challenge in part because a hydrated matrix protects the bacterial community from antibiotics. Herein, we evaluated how different osmotic compounds [maltodextrin, sucrose and polyethylene glycol (PEG)] enhance antibiotic efficacy against Acinetobacter baumannii biofilm communities. Established test-tube biofilms (24 h, strain ATCC 17978) were treated with osmotic compounds in the presence or absence of 10X the minimum inhibitory concentration of different antibiotics (50 μg/ml tobramycin, 20 μg/ml ciprofloxacin, 300 μg/ml chloramphenicol, 30 μg/ml nalidixic acid or 100 μg/ml erythromycin)...
July 21, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28733150/seven-new-lignan-glycosides-from-the-branches-of-alangium-kurzii-craib-var-laxifolium
#4
Jie Ren, Yang-Guo Xie, Ying-Ying Huang, Sheng-Lan Zhu, Shi-Kai Yan, Hui-Zi Jin, Wei-Dong Zhang
Seven new lignan glycosides (1-3, 8-10, and 14) and 17 known compounds were isolated from the branches of Alangium kurzii Craib var. laxifolium. Their structures were established by spectroscopic analysis and circular dichroism (CD) and X-ray analysis. The isolated compounds were evaluated for their antibacterial activities against Staphylococcus aureus CI1011, Streptococcus suis CI1608, Salmonella gallinarum CI0912, Enterococcus faecalis CI1304, Aeromonas hydrophila CI1008, Escherichia coli CI151012, Vibrio parahaemolyticus CI150506, Klebsiella pneumoniae CI131216, Pseudomonas aeruginosa CI1011, Staphylococcus epidermidis CI1110, and Streptococcus agalactiae CI1302...
July 18, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28733126/in-vitro-stepwise-selection-of-reduced-susceptibility-to-lipoglycopeptides-in-enterococci
#5
Francis F Arhin, David Lalonde Seguin, Adam Belley, Gregory Moeck
The propensity of oritavancin to select for stably elevated oritavancin minimum inhibitory concentrations (MICs) was studied by serial passaging of strains in broth containing oritavancin for 20days. Seven clinical strains of Enterococcus faecalis and E. faecium were studied; they included vancomycin-susceptible and both VanA and VanB vancomycin-resistant isolates. Stepwise oritavancin selection yielded stably elevated oritavancin MICs in six of the seven strains, with MIC increases ranging from 4-32-fold. By comparison, stepwise selection with comparator agents dalbavancin (4- to >128-fold MIC increases), telavancin (4-8-fold MIC increases) and daptomycin (4-32-fold MIC increases) also yielded selectants with elevated MICs of the respective agents...
July 1, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28733027/isolation-and-characterization-of-metabolites-from-bacillus-licheniformis-mh48-with-antifungal-activity-against-plant-pathogens
#6
Min-Hae Jeong, Yong-Seong Lee, Jeong-Yong Cho, Young-Sang Ahn, Jae-Hak Moon, Hae-Nam Hyun, Gyu-Suk Cha, Kil-Yong Kim
In this study, we isolated Bacillus licheniformis MH48 from rhizosphere soil and demonstrated that this strain shows significant antifungal activity against Rhizoctonia solani, Colletotrichum gloeosporioides, and Phytophthora capsici. Our results showed that a 50% concentration of bacterial cell-free culture filtrate of B. licheniformis MH48 shows strong activity against fungal pathogens. Benzoic acid produced by B. licheniformis MH48 was purified by various chromatographic techniques and identified by nuclear magnetic resonance and gas chromatography-mass spectrometry analysis...
July 18, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28731389/protease-hydrolysates-of-filefish-thamnaconus-modestus-byproducts-effectively-inhibit-foodborne-pathogens
#7
Shaimaa Hatab, Mei-Ling Chen, Wenhua Miao, Jiheng Lin, Dandan Wu, Changyu Wang, Pengxiang Yuan, Shanggui Deng
In this study, novel antimicrobial peptides had been derived by enzymatic hydrolysis of filefish (Thamnaconus modestus) byproduct (HFBP). Different proteases, (papain [P], trypsin [T], neutrase [N], pepsin [PE], and the mixture I [PN] and mixture II [PT]) and different hydrolysis time (60, 120, 180, and 240 min), have been used to generate peptides with different lengths and amino acid sequences. The antimicrobial properties of HFBPs were tested, against Gram-positive and Gram-negative strains, using disc diffusion method...
July 21, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28730719/anticandidal-activity-of-extracts-and-a-novel-compound-amnomopin-isolated-from-petriella-setifera
#8
Amani S Awaad, Nour K Al-Aonazi, Monerah R Al-Othman, Mohamed E Zain, Reham M El-Meligy, Nabil El-Sayed
A novel triterpenoidal compound named 'amnomopin' (3β-diglucoside-5,12-28-oic acid), which is named IUPAC as 3-O-(2' ➔ 1″diglucoside)1,2,3,4,4a,5,6,6a,6b,7,9,10,11,12,12a,12b,13,14b-octadecahydro-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethylpicene-4a-carboxylic acid, was isolated from the extract Petriella setifera. The total alcoholic extract of P. setifera showed a great activity against clinically isolated Candida species, including Candida albicans, Candida dubliniensis, Candida famata, Candida glabrata, Candida inconspicua, Candida kefyr, Candida krusei, Candida norvegensis, Candida parapsilosis and Candida tropicalis...
July 20, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28729865/a-novel-and-validated-protocol-for-performing-mic-tests-to-determine-the-susceptibility-of-piscirickettsia-salmonis-isolates-to-florfenicol-and-oxytetracycline
#9
Sergio Contreras-Lynch, Peter Smith, Paola Olmos, María E Loy, William Finnegan, Claudio D Miranda
This paper presents a validated protocol, using a novel, specifically formulated medium, to perform broth microdilution antimicrobial susceptibility assays of the salmonid bacterial pathogen Piscirickettsia salmonis. The minimum inhibitory concentrations (MIC) for florfenicol and oxytetracycline against 58 P. salmonis isolates recovered from various outbreaks occurred in Chilean salmonid farms were determined using this protocol. Normalized resistance interpretation (NRI) analysis was applied to these data to calculate appropriate protocol-specific epidemiological cut-off values...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28728591/antimicrobial-susceptibility-pattern-of-clinical-isolates-of-burkholderia-pseudomallei-in-bangladesh
#10
Subarna Dutta, Sabah Haq, Mohammad Rokibul Hasan, Jalaluddin Ashraful Haq
BACKGROUND: Melioidosis an infectious disease, caused by a Gram negative bacterium called Burkholderia pseudomallei, is endemic in Bangladesh. This organism is sensitive to limited number of antimicrobial agents and need prolonged treatment. There is no comprehensive data on the antimicrobial susceptibility profile of B. pseudomallei isolated in Bangladesh over last several years. The present study aimed to determine the antimicrobial susceptibility pattern of B. pseudomallei isolated in a tertiary care hospital of Dhaka city from 2009 to 2015...
July 20, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28725151/chemical-constituents-of-helichrysum-italicum-roth-g-don-essential-oil-and-their-antimicrobial-activity-against-gram-positive-and-gram-negative-bacteria-filamentous-fungi-and-candida-albicans
#11
Bouzid Djihane, Nouioua Wafa, Soltani Elkhamssa, De Haro Juan Pedro, Angeles Esteban Maria, Zerroug Mohamed Mihoub
The aerial parts of Helichrysum italicum (Roth) G. Don were subjected to hydrodistillation to obtain essential oils which had been analyzed by gas chromatography and gas chromatography coupled with mass spectrometry and tested for antimicrobial activity against 12 bacteria, two yeasts and four fungi by agar diffusion method. The essential oil yielded 0.44% (v/w) and 67 compounds accounting for 99.24% of the oil were identified with a high content of oxygenated sesquiterpenes (61.42%). The most oxygenated sesquiterpene compounds were α-Cedrene (13...
July 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28724950/nanocapsules-containing-neem-azadirachta-indica-oil-development-characterization-and-toxicity-evaluation
#12
Tatiane Pasquoto-Stigliani, Estefânia V R Campos, Jhones L Oliveira, Camila M G Silva, Natalia Bilesky-José, Mariana Guilger, Johann Troost, Halley C Oliveira, Renata Stolf-Moreira, Leonardo F Fraceto, Renata de Lima
In this study, we prepared, characterized, and performed toxicity analyses of poly(ε-caprolactone) nanocapsules loaded with neem oil. Three formulations were prepared by the emulsion/solvent evaporation method. The nanocapsules showed a mean size distribution around 400 nm, with polydispersity below 0.2 and were stable for 120 days. Cytotoxicity and genotoxicity results showed an increase in toxicity of the oleic acid + neem formulations according to the amount of oleic acid used. The minimum inhibitory concentrations demonstrated that all the formulations containing neem oil were active...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724858/antibacterial-effect-of-azadirachta-indica-neem-or-curcuma-longa-turmeric-against-enterococcus-faecalis-compared-with-that-of-5-sodium-hypochlorite-or-2-chlorhexidine-in-vitro
#13
Dakshita Joy Sinha, Kanwar D S Nandha, Natasha Jaiswal, Agrima Vasudeva, Shashi Prabha Tyagi, Udai Pratap Singh
The purpose of this study was to compare the antibacterial properties of Azadirachta indica (neem) or Curcuma longa (turmeric) against Enterococcus faecalis with those of 5% sodium hypochlorite or 2% chlorhexidine as root canal irrigants in vitro. The activity of neem, chlorhexidine, sodium hypochlorite, or turmeric against E. faecalis was measured on agar plates using the agar diffusion method. The tube dilution method was used to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the irrigants used...
2017: Bulletin of Tokyo Dental College
https://www.readbyqxmd.com/read/28724383/molecular-characterization-and-genetic-relatedness-of-clinically-acinetobacter-baumanii-isolates-conferring-increased-resistance-to-the-first-and-second-generations-of-tetracyclines-in-iran
#14
Zahra Meshkat, Himen Salimizand, Yousef Amini, Mostafa Khakshoor, Davoud Mansouri, Hadi Farsiani, Kiarash Ghazvini, Adel Najafi
BACKGROUND: The increasing resistance of Acinetobacter baumannii to antibiotics has recently been regarded as a notable therapeutic difficulty. Evaluating resistance rates of some A. baumannii isolates to tetracyclines had an impact on understanding the antibiotic resistance dissemination. By comparing genetic characteristics and relatedness of A. baumannii isolates, we are able to determine the transition dynamics of outbreak isolates. METHODS: A total of 72 non-duplicate isolates of A...
July 19, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28724328/smart-tetrazole-based-antibacterial-nanoparticles-as-multifunctional-drug-carriers-for-cancer-combination-therapy
#15
Elham Zakerzadeh, Roya Salehi, Mehrdad Mahkam
Due to multidrug resistance of cancer tissues and immune-suppression of cancerous patients during chemotherapy in one hand and the use of tetrazole derivatives in medicine because of its anticancer, antifungal and antiviral properties, on the other, we were encouraged to design novel smart antibacterial nanocomposites-based polymer of tetrazole as dual anticancer drug delivery systems. The structures of nanocomposites characterized by FTIR, (1)H NMR, FESEM-EDX and TGA analyses and antibacterial activity of smart carriers were evaluated by determination of minimum inhibitory concentration (MIC) values against some bacteria and fungi...
July 20, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28722476/evaluation-of-resazurin-microtiter-plate-assay-and-hplc-photodiode-array-analysis-of-the-roots-of-asparagus-adscendens
#16
Kashif Maqbool Khan, Lutfun Nahar, Abdul Mannan, Muhammad Arfan, Ghazanfar Ali Khan, Glyn Hobbs, Satyajit D Sarker
Asparagus adscendens Roxb. (Asparagaceae), is native to the Himalayas. The present study, for the first time, was undertaken to explore the antimicrobial potential, to determine the minimum inhibitory concentration (MIC) values of the methanol extract of the roots of A. adscendens and its solid-phase extraction (SPE) fractions using resazurin microtitre assay against Gram-positive and negative bacterial-registered strains and to carry out HPLC-photodiode array analysis of the SPE fractions. The methanol extract and all SPE exhibited considerable level of antibacterial potential against Gram-positive bacteria (MIC: 2...
July 19, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28721014/determining-optimal-dosing-regimen-of-oral-administration-of-dicloxacillin-using-monte-carlo-simulation
#17
Wei Yu, Jinru Ji, Tingting Xiao, Chaoqun Ying, Jiaheng Fang, Ping Shen, Yonghong Xiao
BACKGROUND: Dicloxacillin, a semisynthetic isoxazolyl penicillin, exhibits antimicrobial activity against a wide variety of Gram-positive bacteria, as well as stability against penicillinases and low level of toxicity. The objective of this study was to obtain optimal dosing regimen of oral administration of dicloxacillin by analyzing the pharmacokinetic (PK) index in healthy volunteers and in vitro antibacterial activity by using Monte Carlo simulation. MATERIALS AND METHODS: A total of 867 clinical isolates from community-onset infections were collected from 31 secondary hospitals in People's Republic of China...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28720964/antimicrobial-effect-of-black-pepper-petroleum-ether-extract-for-the-morphology-of-listeria-monocytogenes-and-salmonella-typhimurium
#18
Hui Tang, Wenxue Chen, Zu-Man Dou, Ronghao Chen, Yueying Hu, Weijun Chen, Haiming Chen
This study aimed to evaluate the effects of black pepper petroleum extract (BPPE) on pathogenic bacteria. The extraction from black pepper showed intense antimicrobial activity against the Gram-positive Listeria monocytogenes ATCC 19115 and the Gram-negative bacteria Salmonella typhimurium ATCC 14028. The minimum inhibitory concentrations of BPPE against L. monocytogenes and S. typhimurium were 0.625 and 1.25 mg/ml, respectively. Detection of Alkaline phosphatase outside the cell revealed that BPPE treatment destroyed the cell wall integrity...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28719324/susceptibility-of-clinical-isolates-of-burkholderia-pseudomallei-to-a-lipid-a-biosynthesis-inhibitor
#19
Sineenart Sengyee, Natnaree Saiprom, Suporn Paksanont, Direk Limmathurotsakul, Vanaporn Wuthiekanun, Narisara Chantratita
Burkholderia pseudomallei is the causative agent of melioidosis, a serious infection associated with high mortality and relapse. Current antimicrobial therapy using ceftazidime (CAZ) is often ineffective. Inhibitors of LpxC, the enzyme responsible for lipid A biosynthesis, have potential antimicrobial activity against several Gram-negative bacteria in vivo, but their activity against B. pseudomallei is unclear. Herein, we investigated the susceptibility of B. pseudomallei clinical isolates to LpxC-4, an LpxC inhibitor, and LpxC-4 in combination with CAZ...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28717042/modeling-the-kinetics-of-the-permeation-of-antibacterial-agents-into-growing-bacteria-and-its-interplay-with-efflux
#20
Wright W Nichols
A mathematical model of the passive permeation of a novel solute into bacteria is developed that explicitly accounts for intracellular dilution through growth. A bacterial cell envelope permeability coefficient of >10(-8) cm(2)s(-1) approx., is predicted to ensure passive permeation into rapidly replicating bacterial cells. The relative importance of the permeability coefficients of the cytoplasmic and outer membranes of Gram-negative bacteria in determining the overall envelope permeability coefficient is analyzed quantitatively...
July 17, 2017: Antimicrobial Agents and Chemotherapy
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