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https://www.readbyqxmd.com/read/29793154/juvenile-treatment-with-mglur2-3-agonist-prevents-schizophrenia-like-phenotypes-in-adult-by-acting-through-gsk3%C3%AE
#1
Bo Xing, Genie Han, Min-Juan Wang, Melissa A Snyder, Wen-Jun Gao
Prodromal memory deficits represent an important marker for the development of schizophrenia (SZ), in which glutamatergic hypofunction occurs in the prefrontal cortex (PFC). The mGluR2/3 agonist LY379268 (LY37) attenuates excitatory N-methyl-D-aspartate receptor (NMDAR)-induced neurotoxicity, a central pathological characteristic of glutamatergic hypofunction. We therefore hypothesized that early treatment with LY37 would rescue cognitive deficits and confer benefits for SZ-like behaviors in adults. To test this, we assessed whether early intervention with LY37 would improve learning outcomes in the Morris Water Maze for rats prenatally exposed to methylazoxymethanol acetate (MAM), a neurodevelopmental SZ model...
May 14, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29792180/screening-for-congenital-fetal-anomalies-in-low-risk-pregnancy-the-kenyatta-national-hospital-experience
#2
Callen Kwamboka Onyambu, Norah Mukiri Tharamba
BACKGROUND: Congenital malformations contribute significantly to the disease burden among children globally. A study conducted in Kenya on understanding the burden of surgical congenital anomalies, highlights the need for Kenyan health systems to go beyond the medical dimensions of illness. This could be achieved by linking knowledge of the severe congenital anomalies (CAs) and their impact of varying disability to the delivery of local health services and public health program planning...
May 23, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29788465/factfinders-for-patient-safety-risk-of-bleeding-with-nonaspirin-nonsteroidal-anti-inflammatory-drugs-before-spine-procedures
#3
Zachary L McCormick, Adrian Popescu, Clark Smith
No abstract text is available yet for this article.
May 16, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29786884/bone-morbidity-and-recovery-in-children-with-acute-lymphoblastic-leukemia-results-of-a-six-year-prospective-cohort-study
#4
Leanne M Ward, Jinhui Ma, Bianca Lang, Josephine Ho, Nathalie Alos, Mary Ann Matzinger, Nazih Shenouda, Brian Lentle, Jacob L Jaremko, Beverly Wilson, David Stephure, Robert Stein, Anne Marie Sbrocchi, Celia Rodd, Victor Lewis, Sara Israels, Ronald M Grant, Conrad V Fernandez, David B Dix, Elizabeth A Cummings, Robert Couch, Elizabeth Cairney, Ronald Barr, Sharon Abish, Stephanie A Atkinson, John Hay, Frank Rauch, David Moher, Kerry Siminoski, Jacqueline Halton
Osteoporotic fractures are a significant cause of morbidity in acute lymphoblastic leukemia (ALL). Our objective was to determine the incidence and predictors of fractures and recovery from osteoporosis in pediatric ALL over 6 years following glucocorticoid initiation. Vertebral fractures (VF) and vertebral body reshaping were assessed on annual spine radiographs, low-trauma non-VF were recorded at regular intervals and spine bone mineral density (BMD) was captured every 6 months for 4 years and then annually...
May 22, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29784570/research-gaps-in-wilderness-medicine
#5
Daniel Tritz, Kody Dormire, Travis Brachtenbach, Joshua Gordon, Donald Sanders, David Gearheart, Julia Crawford, Matt Vassar
INTRODUCTION: Wilderness medicine involves the treatment of individuals in remote, austere environments. Given the high potential for injuries as well as the unique treatment modalities required in wilderness medicine, evidence-based clinical practice guidelines are necessary to provide optimal care. In this study, we identify evidence gaps from low-quality recommendations in wilderness medicine clinical practice guidelines and identify new/ongoing research addressing them. METHODS: We included relevant clinical practice guidelines from the Wilderness Medical Society and obtained all 1C or 2C level recommendations...
May 18, 2018: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/29776411/a-study-of-the-factors-associated-with-cervical-spinal-disc-degeneration-with-a-focus-on-bone-metabolism-and-amino-acids-in-the-japanese-population-a-cross-sectional-study
#6
Kanichiro Wada, Toshihiro Tanaka, Gentaro Kumagai, Hitoshi Kudo, Toru Asari, Daisuke Chiba, Seiya Ota, Keita Kamei, On Takeda, Shigeyuki Nakaji, Yasuyuki Ishibashi
BACKGROUND: The physical and biochemical factors responsible for cervical disc degeneration, and resulting in various spinal disorders, remain unclear. This study aimed to evaluate the correlation between cervical spinal canal stenosis and degeneration of intervertebral discs, and to analyze the factors related to disc degeneration in the Japanese population. METHODS: Three hundred and forty-four Japanese general residents underwent investigations, including magnetic resonance imaging of the cervical spine, in our health check project...
May 17, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29767782/factfinders-for-patient-safety-are-gadolinium-based-contrast-media-safe-alternatives-to-iodinated-contrast-agents-for-the-safe-performance-of-spinal-injection-procedures
#7
Adrian Popescu, Jaymin Patel, Zachary L McCormick, Timothy P Maus, Meghan Rodes, David R Walega, Clark C Smith
No abstract text is available yet for this article.
May 14, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29766142/improving-life-expectancy-a-broken-neck-doesn-t-have-to-be-a-terminal-diagnosis-for-the-elderly
#8
Laura N Godat, Leslie M Kobayashi, David C Chang, Raul Coimbra
Background: Elderly patients with cervical spine fractures require optimal care. Treatment with a cervical collar or halo instead of surgical fixation may increase mortality. This investigation intends to describe the life expectancy after injury and evaluate the impact of surgical intervention on mortality. Methods: Patients ≥65 years, with traumatic cervical spine fractures without cord injury were identified in the 1995-2009 California Office of Statewide Health and Planning database...
2018: Trauma surgery & acute care open
https://www.readbyqxmd.com/read/29765179/is-early-treatment-for-mild-adolescent-idiopathic-scoliosis-superior-over-the-traditional-watch-wait-approach-a-case-report-with-long-term-follow-up
#9
Paul A Oakley
[Purpose] To present a case of the complete correction of mild suspected adolescent idiopathic scoliosis in support of the argument that early aggressive treatment is superior to the traditional 'watch & wait' approach. [Subject and Methods] A 9-year-old female presented with a 14° thoracic curve indicative of early adolescent idiopathic scoliosis. The parents consented to immediate and early treatment with the SpineCor dynamic and corrective scoliosis brace. The brace was worn 20 hours per day and check-ups were performed every three months...
May 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29760878/chiropractic-treatment-including-instrument-assisted-manipulation-for-non-specific-dizziness-and-neck-pain-in-community-dwelling-older-people-a-feasibility-randomised-sham-controlled-trial
#10
Julie C Kendall, Simon D French, Jan Hartvigsen, Michael F Azari
Background: Dizziness in older people is a risk factor for falls. Neck pain is associated with dizziness and responds favourably to neck manipulation. However, it is unknown if chiropractic intervention including instrument-assisted manipulation of the neck in older people with neck pain can also improve dizziness. Methods: This parallel two-arm pilot trial was conducted in Melbourne, Australia over nine months (October 2015 to June 2016). Participants aged 65-85 years, with self-reported chronic neck pain and dizziness, were recruited from the general public through advertisements in local community newspapers and via Facebook...
2018: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/29756457/descriptive-analysis-of-associated-factors-for-urgent-versus-nonurgent-inpatient-spine-transfers-to-a-tertiary-care-hospital
#11
Gregory D Schroeder, James C McKenzie, David S Casper, Seth Stake, Joseph Buchholz, Chris Kepler, Jeffery A Rihn, Barret I Woods, Kris E Radcliff, I David Kaye, Kristen Nicholson, D Greg Anderson, Alan S Hilibrand, Alexander R Vaccaro, Safdar Khan, Mark F Kurd
Patients with spine-associated symptoms are transferred regularly to higher levels of care for operative intervention. It is unclear what factors lead to the transfer of patients with spine pathology to level I care facilities, and which transfers are indicated. All patients with isolated spinal pathology who were transferred from 2011 to 2015 were reviewed. Patients were divided into urgent transfers, defined as anyone who required operative intervention, and nonurgent transfers. Two hundred twenty-seven patients were transferred for isolated spinal pathology over 51 months; 109 (48...
May 1, 2018: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/29755230/scoliosis-conservative-treatment-a-review-of-literature
#12
REVIEW
Mohammad Taghi Karimi, Timon Rabczuk
Background: Scoliosis is defined as lateral curvature of the spine which is also associated with a change in the curves in sagittal plane and vertebral rotation. Various types of conservative treatment approaches have been recommended for the patients with scoliosis. The aim of this review article was to introduce the various methods of conservative treatment which can be used for the patients with scoliosis. Methods: A search was done in some databases including PubMed, ISI Web of knowledge, Google scholar, Ebsco, Embasco, and Scopus...
January 2018: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29752520/mucopolysaccharidoses-overview-of-neuroimaging-manifestations
#13
Manal Nicolas-Jilwan, Moeenaldeen AlSayed
The mucopolysaccharidoses are a heterogeneous group of inherited lysosomal storage disorders, characterized by the accumulation of undegraded glycosaminoglycans in various organs, leading to tissue damage. Mucopolysaccharidoses include eight individual disorders (IS [Scheie syndrome], IH [Hurler syndrome], II, III, IV, VI, VII and IX). They have autosomal-recessive transmission with the exception of mucopolysaccharidosis II, which is X-linked. Each individual disorder has a wide spectrum of phenotypic variation, depending on the specific mutation, from very mild to very severe...
May 11, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29752238/robotic-spine-exoskeleton-rose-characterizing-the-3-d-stiffness-of-the-human-torso-in-the-treatment-of-spine-deformity
#14
Joon-Hyuk Park, Paul R Stegall, David P Roye, Sunil K Agrawal
Spine deformity is typically treated with a brace that fits around the torso and hips to correct the abnormal curve of the spine. While bracing has been shown to curtail progression of abnormal spine curves, current braces impose several limitations due to their rigid, static, and sensor-less designs: (1) forces and moments exerted by the brace cannot be measured or modulated and (2) the 3-D stiffness of the human torso has not been characterized-these may be important factors to be considered in bracing treatment...
May 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29749918/operative-and-consultative-proportions-of-neurosurgical-disease-worldwide-estimation-from-the-surgeon-perspective
#15
Michael C Dewan, Abbas Rattani, Ronnie E Baticulon, Serena Faruque, Walter D Johnson, Robert J Dempsey, Michael M Haglund, Blake C Alkire, Kee B Park, Benjamin C Warf, Mark G Shrime
OBJECTIVE The global magnitude of neurosurgical disease is unknown. The authors sought to estimate the surgical and consultative proportion of diseases commonly encountered by neurosurgeons, as well as surgeon case volume and perceived workload. METHODS An electronic survey was sent to 193 neurosurgeons previously identified via a global surgeon mapping initiative. The survey consisted of three sections aimed at quantifying surgical incidence of neurological disease, consultation incidence, and surgeon demographic data...
May 11, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29746965/spine-and-lower-extremity-kinematics-during-gait-in-cervical-spondylotic-myelopathy-patients
#16
Ram Haddas, Sujal Patel, Raj Arakal, Akwasi Boah, Theodore Belanger, Kevin L Ju
BACKGROUND CONTEXT: CSM typically manifests with a slow, progressive stepwise decline in neurologic function, including hand clumsiness and balance difficulties. Gait disturbances are frequently seen in CSM patients, with more advanced cases exhibiting a stiff, spastic gait. PURPOSE: To evaluate the spatiotemporal parameters and spine and lower extremity kinematics during the gait cycle of adult cervical spondylotic myelopathy (CSM) patients prior to surgical intervention...
May 7, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29745626/train-the-brain-immediate-sensorimotor-effects-of-mentally-performed-flexor-exercises-in-patients-with-neck-pain-a-pilot-study
#17
Konstantin Beinert, Marc Sofsky, Jörg Trojan
BACKGROUND: Sensorimotor tests, like cranio- cervical flexion and cervical joint position sense tests, share a strong cognitive component during their execution. However, cognitive training for those tests has not been investigated so far. AIM: To compare mental and physical exercises for improving the sensorimotor function of the cervical spine. DESIGN: A within-subject design with 16 participants. SETTING: Outpatient physiotherapy centre...
May 9, 2018: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29744453/studies-on-the-cytocompatibility-mechanical-and-antimicrobial-properties-of-3d-printed-poly-methyl-methacrylate-beads
#18
David K Mills, Uday Jammalamadaka, Karthik Tappa, Jeffery Weisman
Osteomyelitis is typically a bacterial infection (usually from Staphylococcus) or, more rarely, a fungal infection of the bone. It can occur in any bone in the body, but it most often affects the long bones (leg and arm), vertebral (spine), and bones of the foot. Microbial success in osteomyelitis is due to their ability to form biofilms which inhibit the wound healing process and increases resistance to anti-infective agents. Also, biofilms do not allow easy penetration of antibiotics into their matrix making clinical treatment a challenge...
June 2018: Bioactive Materials
https://www.readbyqxmd.com/read/29742889/intraoperative-neurophysiological-monitoring-a-review-of-techniques-used-for-brain-tumor-surgery-in-children
#19
REVIEW
Keewon Kim, Charles Cho, Moon-Suk Bang, Hyung-Ik Shin, Ji-Hoon Phi, Seung-Ki Kim
Intraoperative monitoring (IOM) utilizes electrophysiological techniques as a surrogate test and evaluation of nervous function while a patient is under general anesthesia. They are increasingly used for procedures, both surgical and endovascular, to avoid injury during an operation, examine neurological tissue to guide the surgery, or to test electrophysiological function to allow for more complete resection or corrections. The application of IOM during pediatric brain tumor resections encompasses a unique set of technical issues...
May 2018: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29741744/fact-finders-for-patient-safety-intra-articular-corticosteroid-injections-and-hyperglycemia
#20
Jaymin Patel, Byron J Schneider, Clark C Smith
No abstract text is available yet for this article.
May 1, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
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