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https://www.readbyqxmd.com/read/28938620/pathological-expression-of-tissue-factor-confers-promising-antitumor-response-to-a-novel-therapeutic-antibody-sc1-in-triple-negative-breast-cancer-and-pancreatic-adenocarcinoma
#1
Xuesai Zhang, Qingrou Li, Hui Zhao, Lanping Ma, Tao Meng, Jianchang Qian, Rui Jin, Jingkang Shen, Ker Yu
The pathological presence of tissue factor (TF) in cancer cells promotes tumor-initiated thrombosis and cancer metastasis. We found that TF is aberrantly present in large percentage of aggressive triple negative breast cancer (TNBC) and pancreatic adenocarcinoma (PaC), two most lethal forms of malignancy that urgently need effective treatment. TF expression in TNBC clustered with higher levels of vimentin, basal-type keratins KRT5/14 and caveolin-1 but lower levels of luminal-type biomarkers. We developed a novel and specific anti-TF therapeutic antibody SC1, which displayed an exceedingly high potency against TF extracellular domain (EC50: 0...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937364/nucleic-acid-amplification-testing-in-indian-blood-banks-a-review-with-perspectives
#2
Kanjaksha Ghosh, Kanchan Mishra
BACKGROUND: Nucleic acid amplification testing (NAT) is restricted to a few blood banks in India since 2008. This review was directed toward understanding NAT yield in different parts of the country and prevalence in the NAT of different types of virus. MATERIALS AND METHODS: English literature was searched from 1990 to 2016 in PubMed, Scopus, Ind med, and Google database using properly constructed key words. Literature was collected and finally the data were synthesized...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28936594/transcatheter-aortic-valve-replacement-outcomes-indications-complications-and-innovations
#3
REVIEW
Michael N Young, Ignacio Inglessis
Transcatheter aortic valve replacement (TAVR) has become the standard of care for the treatment of severe aortic stenosis in individuals who are at prohibitive surgical risk and presents a viable alternative to surgery in selected patients who are at high operative risk. To date, outcomes from the PARTNER (Placement of AoRtic TraNscathetER Valve) and Medtronic CoreValve® US Pivotal trials continue to show the benefits of TAVR in these high-risk subgroups out to 5 and 3 years, respectively (as reported by Mack et al...
September 22, 2017: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28935543/the-effect-of-acute-caffeine-intake-on-insulin-sensitivity-and-glycemic-control-in-people-with-diabetes
#4
REVIEW
Lisa Dewar, Roschelle Heuberger
The prevalence of diabetes is growing globally, and with no current cure for the disease, management is focused on optimizing blood glucose control to limit complications. The purpose of this review was to examine the effect of caffeine intake on blood glucose levels in people with diabetes. Electronic searches were completed using Pub Med, CINAHL, and Web of Science using the search terms "coffee and insulin," "caffeine and insulin," "caffeine and diabetes," "caffeine and type 1 diabetes," "caffeine and type 2 diabetes," and "caffeine and glycemia...
April 23, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28934804/comparison-of-7-surgical-interventions-for-lumbar-disc-herniation-a-network-meta-analysis
#5
Fan Feng, Qianqian Xu, Feifei Yan, Yuanlong Xie, Zhouming Deng, Chao Hu, Xiaobin Zhu, Lin Cai
BACKGROUND: The number of interventions on intervertebral discs rapidly increased and the treatment options for lumbar disc surgery quickly evolved. It is important that the safety and efficacy of all new innovative procedures be compared with currently accepted forms of treatment; however, the previous pairwise meta-analyses could not develop the hierarchy of these treatments. OBJECTIVES: The purpose of the study is to perform a network meta-analysis to evaluate the clinical results of 7 surgical interventions for the treatment of lumbar disc herniation...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28933919/re-chinese-tcm-renaissance-and-the-global-movement-for-integrative-health-and-medicine-by-weeks-j-altern-complement-med-2017-23-79-81
#6
Arthur Yin Fan, Sarah Faggert
No abstract text is available yet for this article.
September 21, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28931973/the-effects-of-place-running-exercises-on-the-pulmonary-function-of-normal-adults
#7
KyoChul Seo, MiSuk Cho
[Purpose] The purpose of this study was to determine whether place running exercises increase the pulmonary function of normal adults. [Subjects and Methods] Thirty normal adults in their 20s were randomly assigned to an experimental group (n=15) or a control group (n=15). Over the course of four weeks, the experimental group participated in place running exercise for 30 minutes five times per week. The control group only participated in moto-med exercise for 30 minutes five times per week. Subjects were assessed pre- and post-test by measuring the tidal volume, inspiratory reserve volume, expiratory reserve volume, and vital capacity...
September 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28930303/mitigation-measures-of-electromagnetic-field-exposure-in-the-vicinity-of-high-frequency-welders
#8
Bartłomiej Zubrzak, Pawel Bieńkowski, Pawel Cała
BACKGROUND: Presented information about the welding process and equipment, focusing on the emission of electromagnetic field (EMF) with levels significant in terms of the labor safety regulations in force in Poland - the ordinances of the Minister of Family, Labour and Social Policy that came into force on June 27, 2016 and June 29, 2016 - emerged due to harmonization with EU directive 2013/35/EU of 26 June 2013 of the European Parliament and the Council. They presented methods of determination of the EMF distribution in the welding machine surroundings and analyzed the background knowledge from the available literature...
September 20, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28930302/-accidental-severe-poisoning-with-methemoglobinogenic-substance-a-case-report
#9
Kinga Rośniak-Bąk, Marek Bąk, Renata Winnicka, Anna Krakowiak
A 45-year-old male patient was admitted to the Regional Poison Center because of poisoning with dimethyloaniline contained in a toxic resin-curing dimethyl aniline-based formulation ingested inadvertently. Intoxication happened at workplace. The patient was then transferred to the Toxicology Clinic, where he stayed for 3 weeks. During the hospitalization, the primary method of treatment involved administration of methylene blue, which is the antidote of choice in such cases. During the intensive care and treatment of the patient massive intravascular hemolysis was seen...
September 20, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28930301/night-shift-work-and-risk-of-compromised-visual-acuity-among-the-workers-in-an-electronics-manufacturing-company
#10
Yu-Cheng Lin, Kuo-Jung Ho
OBJECTIVES: To evaluate the association between night-shift work exposure and visual health, this cross-sectional study utilized visual acuity, a surrogate measure for visual function, as a parameter, and performed an analysis comparing visual acuity between daytime and nighttime employees in an electronics manufacturing company. MATERIAL AND METHODS: Data of personal histories, occupational records, physical examinations and blood tests was obtained from the electronic health records of workers...
September 20, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28930300/assessment-of-shoulder-and-low-back-muscle-activity-of-male-kitchen-workers-using-surface-electromyography
#11
Shankar Subramaniam, Shanmugam Murugesan, Srinivasan Jayaraman
OBJECTIVES: This study aims to assess muscle fatigue for kitchen workers during various tasks in a kitchen. MATERIAL AND METHODS: This study consists of 2 phases: a) surface electromyography (EMG) to determine muscle fatigue of trapezius and erector spinae muscles bilaterally for 12 healthy male volunteers during 30 min of Indian flatbread (chapati) preparation, b) self-administered questionnaire study after 30 min preparation to determine the impact on performance...
September 20, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28929984/developing-a-hospital-disaster-preparedness-plan-for-mass-casualty-incidents-lessons-learned-from-the-downtown-beirut-bombing
#12
Mazen El Sayed, Ali F Chami, Eveline Hitti
Mass casualty incidents (MCIs) are becoming more frequent worldwide, especially in the Middle East where violence in Syria has spilled over to many neighboring countries. Lebanon lacks a coordinated prehospital response system to deal with MCIs; therefore, hospital preparedness plans are essential to deal with the surge of casualties. This report describes our experience in dealing with an MCI involving a car bomb in an urban area of downtown Beirut, Lebanon. It uses general response principles to propose a simplified response model for hospitals to use during MCIs...
September 20, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28926589/meta-analysis-of-promoter-methylation-in-eight-tumor-suppressor-genes-and-its-association-with-the-risk-of-thyroid-cancer
#13
Fatemeh Khatami, Bagher Larijani, Ramin Heshmat, Abbasali Keshtkar, Mahsa Mohammadamoli, Ladan Teimoori-Toolabi, Shirzad Nasiri, Seyed Mohammad Tavangar
Promoter methylation in a number of tumor-suppressor genes (TSGs) can play crucial roles in the development of thyroid carcinogenesis. The focus of the current meta-analysis was to determine the impact of promoter methylation of eight selected candidate TSGs on thyroid cancer and to identify the most important molecules in this carcinogenesis pathway. A comprehensive search was performed using Pub Med, Scopus, and ISI Web of Knowledge databases, and eligible studies were included. The methodological quality of the included studies was evaluated according to the Newcastle Ottawa scale table and pooled odds ratios (ORs); 95% confidence intervals (CIs) were used to estimate the strength of the associations with Stata 12...
2017: PloS One
https://www.readbyqxmd.com/read/28925348/identification-with-terrorist-attack-victims-association-with-television-viewing-and-prior-life-threat
#14
Holly B Herberman Mash, Carol S Fullerton, K Nikki Benevides, Robert J Ursano
OBJECTIVE: A series of sniper attacks in the Washington, DC, area left 10 people dead and 3 wounded. We developed and tested a model that examined the unique and interdependent relationships of sniper-related television viewing, prior life-threatening events, and parental status to identification with attack victims. METHODS: Participants were 1238 residents of the DC area (aged 18-90 years, mean=41.7 years; 51% female; 68% white) who completed an online survey that assessed identification with sniper attack victims, amount of television viewing, and prior life-threatening events...
September 19, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28925344/prehospital-response-time-delays-for-emergency-patients-in-events-of-concurrent-mass-casualty-incidents
#15
Jungeun Kim, Chu Hyun Kim, Sang Do Shin, Ju Ok Park
OBJECTIVE: We investigated the extent of delays in the response time of emergency medical services (EMS) as an impact of mass casualty incidences (MCIs) in the same area. METHODS: We defined an MCI case as an event that resulted in 6 or more patients being transported by EMS, and prehospital response time as the time from the call to arrival at the scene. We matched patients before and after MCIs by dividing them into categories of 3 hours before, 0-1 hour after, 1-2 hours after, and 2-3 hours after the MCIs...
September 19, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28925342/a-study-of-selected-ethnic-affiliations-in-the-development-of-post-traumatic-stress-disorder-and-other-psychopathology-after-a-terrorist-bombing-in-nairobi-kenya
#16
Carol S North, Tatiana Dvorkina, Samuel Thielman, Betty Pfefferbaum, Pushpa Narayanan, David E Pollio
OBJECTIVES: Despite the frequency of disasters in Africa, almost nothing is known about ethnic affiliations in relation to psychopathology after such incidents. This study examined the mental health outcomes of members of 7 major ethnic groups exposed to the 1998 terrorist bombing of the US Embassy in Nairobi, Kenya. METHODS: Approximately 8 to 10 months after the disaster, 229 civilian employees, 99 locally engaged staff workers of the US State Department and the US Agency for International Development, and 64 workers of the Kenyan Red Cross Society (total N=392) were assessed with the Diagnostic Interview Schedule for the Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition)...
September 19, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28923562/intralesional-injection-of-collagenase-clostridium-histolyticum-may-increase-the-risk-of-late-onset-penile-fracture
#17
REVIEW
Jonathan A Beilan, Jared J Wallen, Adam S Baumgarten, Kevin N Morgan, Justin L Parker, Rafael E Carrion
INTRODUCTION: The use of intralesional injection of collagenase Clostridium histolyticum (CCH) has become a valid treatment option in the management of Peyronie's disease (PD). Multiple studies have shown the drug's safety and efficacy. However, sparse literature exists on the utility of the injection protocol's 14-day "observation period," in which patients are instructed to abstain from all sexual activity. AIM: To summarize the contemporary literature and report on our series of patients treated with CCH in an effort to explore the effectiveness of the postinjection observation period...
September 8, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28923561/update-on-the-safety-of-phosphodiesterase-type-5-inhibitors-for-the-treatment-of-erectile-dysfunction
#18
REVIEW
Faysal A Yafi, Ira D Sharlip, Edgardo F Becher
INTRODUCTION: Phosphodiesterase type 5 inhibitors (PDE5Is) have demonstrated efficacy in the treatment of erectile dysfunction (ED). Although historically found to have limited drug-related adverse events, emerging data have suggested that PDE5Is might be associated with melanoma or recurrence of prostate cancer after radical prostatectomy. AIM: To summarize the literature on the safety of PDE5Is. METHODS: A literature review was performed through PubMed from 1990 through 2016 regarding ED...
September 8, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28923310/factors-associated-with-specific-diagnostic-and-statistical-manual-of-mental-disorders-fourth-edition-sexual-dysfunctions-in-breast-cancer-survivors-a-study-of-patients-and-their-partners
#19
Susanna B Hummel, Daniela E E Hahn, Jacques J D M van Lankveld, Hester S A Oldenburg, Eva Broomans, Neil K Aaronson
BACKGROUND: Many women develop sexual problems after breast cancer (BC) treatment. Little is known about BC survivors with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) sexual dysfunction and their partners, and the factors associated with their sexual functioning. AIM: To evaluate (i) patient-related and clinical factors associated with (a) specific DSM-IV sexual dysfunctions and (b) level of sexual functioning and sexual distress as reported by BC survivors and (ii) the association between the sexual functioning of BC survivors and that of their partners...
September 8, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28923309/altered-penile-caveolin-expression-in-diabetes-potential-role-in-erectile-dysfunction
#20
Jay Parikh, Alice Zemljic-Harpf, Johnny Fu, Dimosthenis Giamouridis, Tung-Chin Hsieh, Adam Kassan, Karnam S Murthy, Valmik Bhargava, Hemal H Patel, M Raj Rajasekaran
BACKGROUND: The pathophysiology of increased severity of erectile dysfunction in men with diabetes and their poor response to oral pharmacotherapy are unclear. Defective vascular endothelium and consequent impairment in the formation and action of nitric oxide (NO) are implicated as potential mechanisms. Endothelial NO synthase, critical for NO generation, is localized to caveolae, plasma membrane lipid rafts enriched in structural proteins, and caveolins. Type 2 diabetes mellitus (T2DM)-induced changes in caveolin expression are recognized to play a role in cardiovascular dysfunction...
September 8, 2017: Journal of Sexual Medicine
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