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https://www.readbyqxmd.com/read/28633681/copewell-a-conceptual-framework-and-system-dynamics-model-for-predicting-community-functioning-and-resilience-after-disasters
#1
Jonathan M Links, Brian S Schwartz, Sen Lin, Norma Kanarek, Judith Mitrani-Reiser, Tara Kirk Sell, Crystal R Watson, Doug Ward, Cathy Slemp, Robert Burhans, Kimberly Gill, Tak Igusa, Xilei Zhao, Benigno Aguirre, Joseph Trainor, Joanne Nigg, Thomas Inglesby, Eric Carbone, James M Kendra
OBJECTIVE: Policy-makers and practitioners have a need to assess community resilience in disasters. Prior efforts conflated resilience with community functioning, combined resistance and recovery (the components of resilience), and relied on a static model for what is inherently a dynamic process. We sought to develop linked conceptual and computational models of community functioning and resilience after a disaster. METHODS: We developed a system dynamics computational model that predicts community functioning after a disaster...
June 21, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28633385/timiner-ngs-data-mining-pipeline-for-cancer-immunology-and-immunotherapy
#2
Elias Tappeiner, Francesca Finotello, Pornpimol Charoentong, Clemens Mayer, Dietmar Rieder, Zlatko Trajanoski
Summary: Recently, a number of powerful computational tools for dissecting tumor-immune cell interactions from next-generation sequencing (NGS) data have been developed. However, the assembly of analytical pipelines and execution of multi-step workflows are laborious and involve a large number of intermediate steps with many dependencies and parameter settings. Here we present TIminer, an easy-to-use computational pipeline for mining tumor-immune cell interactions from NGS data. TIminer enables integrative immunogenomic analyses, including: human leukocyte antigens typing, neoantigen prediction, characterization of immune infiltrates, and quantification of tumor immunogenicity...
June 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28632449/prevalence-of-essential-hypertension-and-its-complications-among-chinese-population-at-high-altitude
#3
Le Yue, Zhiqing Fan, Lin Sun, Wei Feng, Jingjie Li
Yue Le, Zhiqing Fan, Lin Sun, Wei Feng, and Jingjie Li. Prevalence of essential hypertension and its complications among Chinese population at high altitude. High Alt Med Biol. 18:140-144, 2017. OBJECTIVES: This study examined the prevalence of essential hypertension (EH) and its complications among Chinese population at different altitude regions in Qinghai province. METHODS: This cross-sectional analysis used data from 2000 residents living in the area with two different latitudes for more than 20 years, using 1:1 pairing mode...
June 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28632286/consort-extension-for-chinese-herbal-medicine-formulas-2017-recommendations-explanation-and-elaboration-traditional-chinese-version
#4
Chung-Wah Cheng, Tai-Xiang Wu, Hong-Cai Shang, You-Ping Li, Douglas G Altman, David Moher, Zhao-Xiang Bian
Editors' Note: This article is the traditional Chinese version of the CONSORT Extension for Chinese Herbal Medicine Formulas 2017: Recommendations, Explanation, and Elaboration. (Cheng C, Wu T, Shang H, Li, Y, Altman D, Moher D; CONSORT-CHM Formulas 2017 Group. CONSORT Extension for Chinese Herbal Medicine Formulas 2017: Recommendations, Explanation, and Elaboration. Ann Intern Med. 2017. [Epub 27 June 2017]. doi:10.7326/M16-2977).
June 27, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28632281/consort-extension-for-chinese-herbal-medicine-formulas-2017-recommendations-explanation-and-elaboration-simplified-chinese-version
#5
Chung-Wah Cheng, Tai-Xiang Wu, Hong-Cai Shang, You-Ping Li, Douglas G Altman, David Moher, Zhao-Xiang Bian
Editors' Note: This article is the simplified Chinese version of the CONSORT Extension for Chinese Herbal Medicine Formulas 2017: Recommendations, Explanation, and Elaboration. (Cheng C, Wu T, Shang H, Li, Y, Altman D, Moher D; CONSORT-CHM Formulas 2017 Group. CONSORT Extension for Chinese Herbal Medicine Formulas 2017: Recommendations, Explanation, and Elaboration. Ann Intern Med. 2017. [Epub 27 June 2017]. doi:10.7326/M16-2977).
June 27, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28631945/vildagliptin-any-effect-on-non-alcoholic-fatty-liver-disease-and-serum-uric-acid-re-shelbaya-s-rakha-s-effectiveness-and-safety-of-vildagliptin-and-vildagliptin-add-on-to-metformin-in-real-world-settings-in-egypt-results-from-the-guard-study-curr-med-res-opin
#6
https://www.readbyqxmd.com/read/28631853/high-sensitivity-mr-acoustic-radiation-force-imaging-using-transition-band-balanced-steady-state-free-precession
#7
Yuan Zheng, Michael Marx, G Wilson Miller, Kim Butts Pauly
PURPOSE: MR acoustic radiation force imaging (MR-ARFI) provides a method to visualize the focal spot of a focused ultrasound (FUS) beam without introducing a significant temperature rise. With conventional spoiled MR-ARFI pulse sequences, the ARFI phase always equals the motion-encoded phase. In this work, MR-ARFI using transition band balanced steady-state free precession (bSSFP) is presented, which improves the sensitivity of MR-ARFI with high acquisition speed. THEORY AND METHODS: Motion-encoding gradients (MEG) are inserted into bSSFP sequences for MR-ARFI...
June 20, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28631337/a-method-to-assess-the-loss-of-a-dipole-antenna-for-ultra-high-field-mri
#8
Gang Chen, Christopher M Collins, Daniel K Sodickson, Graham C Wiggins
PURPOSE: To describe a new bench measurement based on quality (Q) factors to estimate the coil noise relative to the sample noise of dipole antennas at 7 T. METHODS: Placing a dipole antenna close to a highly conductive sample surrogate (HCSS) greatly reduces radiation loss, and using QHCSS gives a more accurate estimate of coil resistance than Qunloaded . Instead of using the ratio of unloaded and sample-loaded Q factors, the ratio of HCSS-loaded and sample-loaded Q factors should be used at ultra-high fields...
June 19, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28630565/efficacy-of-various-scoring-systems-for-predicting-the-28-day-survival-rate-among-patients-with-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-requiring-emergency-intensive-care
#9
Zhihong Feng, Tao Wang, Ping Liu, Sipeng Chen, Han Xiao, Ning Xia, Zhiming Luo, Bing Wei, Xiuhong Nie
We aimed to investigate the efficacy of four severity-of-disease scoring systems in predicting the 28-day survival rate among patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) requiring emergency care. Clinical data of patients with AECOPD who required emergency care were recorded over 2 years. APACHE II, SAPS II, SOFA, and MEDS scores were calculated from severity-of-disease indicators recorded at admission and compared between patients who died within 28 days of admission (death group; 46 patients) and those who did not (survival group; 336 patients)...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28628884/proteomics-profiling-reveals-inflammatory-biomarkers-of-antidepressant-treatment-response-findings-from-the-co-med-trial
#10
Bharathi S Gadad, Manish K Jha, Bruce D Grannemann, Taryn L Mayes, Madhukar H Trivedi
Animal and human studies suggest an association between depression and aberrant immune response. Further, common inflammatory markers may change during the course of antidepressant treatment in patients. The objective of this study was to evaluate changes in inflammatory markers and clinical outcomes from subjects enrolled in the Combining Medications to Enhance Depression Outcome (CO-MED) trial. At baseline and week 12 (treatment completion), plasma samples of 102 participants were analyzed via a multiplex assay comprised of inflammatory markers using a 27-plex standard assay panel plus a 4-plex human acute phase xMAP technology based platform...
May 26, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28628341/observational-study-of-neural-respiratory-drive-during-sleep-at-high-altitude
#11
Joerg Steier, Nic Cade, Ben Walker, John Moxham, Caroline Jolley
Steier, Joerg, Nic Cade, Ben Walker, John Moxham, and Caroline Jolley. Observational study of neural respiratory drive during sleep at high altitude. High Alt Med Biol. 16:000-000, 2017. AIMS: Ventilation at altitude changes due to altered levels of pO2, pCO2 and the effect on blood pH. Nocturnal ventilation is particularly exposed to these changes. We hypothesized that an increasing neural respiratory drive (NRD) is associated with the severity of sleep-disordered breathing at altitude...
June 19, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28627037/quantitative-gd-dota-uptake-from-cerebrospinal-fluid-into-rat-brain-using-3d-vfa-spgr-at-9-4t
#12
Hedok Lee, Kristian Mortensen, Simon Sanggaard, Palle Koch, Hans Brunner, Bjørn Quistorff, Maiken Nedergaard, Helene Benveniste
PURPOSE: We propose a quantitative technique to assess solute uptake into the brain parenchyma based on dynamic contrast-enhanced MRI (DCE-MRI). With this approach, a small molecular weight paramagnetic contrast agent (Gd-DOTA) is infused in the cerebral spinal fluid (CSF) and whole brain gadolinium concentration maps are derived. METHODS: We implemented a 3D variable flip angle spoiled gradient echo (VFA-SPGR) longitudinal relaxation time (T1) technique, the accuracy of which was cross-validated by way of inversion recovery rapid acquisition with relaxation enhancement (IR-RARE) using phantoms...
June 19, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28626999/presence-of-time-dependent-diffusion-in-the-brachial-plexus
#13
Zaid B Mahbub, Andrew M Peters, Penny A Gowland
PURPOSE: This work describes the development of a method to measure the variation of apparent diffusion coefficient (ADC) with diffusion time (Δ) in the brachial plexus, as a potential method of probing microstructure. METHODS: Diffusion-weighted MRI with body signal suppression was used to highlight the nerves from surrounding tissues, and sequence parameters were optimized for sensitivity to change with diffusion time. A porous media-restricted diffusion model based on the Latour-Mitra equation was fitted to the diffusion time-dependent ADC data from the brachial plexus nerves and cord...
June 19, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28626998/large-coverage-black-bright-blood-interleaved-imaging-sequence-labbi-for-3d-dynamic-contrast-enhanced-mri-of-vessel-wall
#14
Haikun Qi, Feng Huang, Zechen Zhou, Peter Koken, Niranjan Balu, Bida Zhang, Chun Yuan, Huijun Chen
PURPOSE: To propose a large coverage black-bright blood interleaved imaging sequence (LaBBI) for 3D dynamic contrast-enhanced MRI (DCE-MRI) of the vessel wall. METHODS: LaBBI consists of a 3D black-blood stack-of-stars golden angle radial acquisition with high spatial resolution for vessel wall imaging and a 2D bright-blood Cartesian acquisition with high temporal resolution for arterial input function estimation. The two acquisitions were performed in an interleaved fashion within a single scan...
June 19, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28626964/impact-of-prior-distributions-and-central-tendency-measures-on-bayesian-intravoxel-incoherent-motion-model-fitting
#15
Oscar Gustafsson, Mikael Montelius, Göran Starck, Maria Ljungberg
PURPOSE: Bayesian model fitting has been proposed as a robust alternative for intravoxel incoherent motion (IVIM) model-fitting parameter estimation. However, consensus regarding choice of prior distribution and posterior distribution central tendency measure is needed. The aim of this study was to compare the quality of IVIM parameter estimates produced by different prior distributions and central tendency measures, and to gain knowledge about the effect of these choices. METHODS: Three prior distributions (uniform, reciprocal, and lognormal) and two measures of central tendency (mean and mode) found in the literature were studied using simulations and in vivo data from a tumor mouse model...
June 19, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28626962/three-dimensional-motion-corrected-sensitivity-encoding-reconstruction-for-multi-shot-multi-slice-mri-application-to-neonatal-brain-imaging
#16
Lucilio Cordero-Grande, Emer J Hughes, Jana Hutter, Anthony N Price, Joseph V Hajnal
PURPOSE: To introduce a methodology for the reconstruction of multi-shot, multi-slice magnetic resonance imaging able to cope with both within-plane and through-plane rigid motion and to describe its application in structural brain imaging. THEORY AND METHODS: The method alternates between motion estimation and reconstruction using a common objective function for both. Estimates of three-dimensional motion states for each shot and slice are gradually refined by improving on the fit of current reconstructions to the partial k-space information from multiple coils...
June 19, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28625702/national-trends-in-the-frequency-of-bladder-catheterization-and-physician-diagnosed-catheter-associated-urinary-tract-infections-results-from-the-medicare-patient-safety-monitoring-system
#17
Mark L Metersky, Noel Eldridge, Yun Wang, Eric M Mortensen, Jennifer Meddings
BACKGROUND: It is unclear if bladder catheterization and catheter-associated urinary tract infection (CAUTI) rates have changed since the implementation of public reporting in 2011. METHODS: We analyzed data from the Medicare Patient Safety Monitoring System, a national, chart abstraction-based surveillance system, for hospitalized adults with a principal discharge diagnosis of heart failure (HF), acute myocardial infarction (AMI), or pneumonia and patients who had undergone certain major surgeries...
June 15, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28625441/the-protective-effects-of-dexmedetomidine-on-ischemic-brain-injury-a-meta-analysis
#18
REVIEW
Lianxiang Jiang, Meizhu Hu, Yan Lu, Ya Cao, Yan Chang, Zeping Dai
BACKGROUND: Intracranial lesions, trauma or surgery-related damage activate immune inflammation and neuroendocrine responses, causing ischemic brain injury. Studies have shown that inflammatory cascade mediated by neuroendocrine hormones and proinflammatory mediators is implicated in the pathophysiology of ischemic brain injury. Alpha2-adrenoceptor agonists, dexmedetomidine, is widely used as neuroprotectants in anesthesia practice. However, it is still lack of a comprehensive meta-analysis to evaluate the neuroprotection of dexmedetomidine against ischemic brain injury via suppressing these two physiological responses...
August 2017: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/28625230/health-care-student-knowledge-and-willingness-to-work-in-infectious-disease-outbreaks
#19
Rima Patel, Kapil Wattamwar, Jaya Kanduri, Meghan Nahass, Jennifer Yoon, Justin Oh, Parth Shukla, Clifton R Lacy
OBJECTIVE: Health care workers are critical first responders. Understanding which factors motivate their willingness to work (WTW) during infectious disease outbreaks may guide improvements in preparedness. The perspective of health care students, the future workforce, remains largely unexplored. This study compared factors influencing WTW among medical, nursing, and pharmacy students. METHODS: A printed survey was administered to 631 medical, nursing, and pharmacy students...
June 19, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28625229/mass-gathering-medical-care-in-electronic-dance-music-festivals
#20
Kathleen M FitzGibbon, Jose V Nable, Benjamin Ayd, Benjamin J Lawner, Angela C Comer, Richard Lichenstein, Matthew J Levy, Kevin G Seaman, Ian Bussey
Introduction Electronic dance music (EDM) festivals represent a unique subset of mass-gathering events with limited guidance through literature or legislation to guide mass-gathering medical care at these events. Hypothesis/Problem Electronic dance music festivals pose unique challenges with increased patient encounters and heightened patient acuity under-estimated by current validated casualty predication models. METHODS: This was a retrospective review of three separate EDM festivals with analysis of patient encounters and patient transport rates...
June 19, 2017: Prehospital and Disaster Medicine
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