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breast cancer surgery, gastric cancer surgery, colorectal cancer surgery

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https://www.readbyqxmd.com/read/27835633/tumor-specific-d-dimer-concentration-ranges-and-influencing-factors-a-cross-sectional-study
#1
Jing Yu, Dongqing Li, Dansheng Lei, Feng Yuan, Feng Pei, Huifeng Zhang, Anming Yu, Kun Wang, Hu Chen, Liang Chen, Xianglei Wu, Xianli Tong, Yefu Wang
D-dimer level in cancer patients is associated with risk of venous thromboembolism and deep venous thrombosis. Most cancer patients have "abnormal" D-dimer levels based on the current normal reference range. To investigate tumor-specific D-dimer reference range, we compared D-dimer levels for nine different tumour types with healthy controls by using simultaneous quantile regression and constructing a median, 5th percentile, and 95th percentile model of normal tumour D-dimer concentration. Associations with tumour primary site, stage, pathological type, and treatment were also explored...
2016: PloS One
https://www.readbyqxmd.com/read/27549784/one-step-nucleic-acid-amplification-osna-where-do-we-go-with-it
#2
Yasuhiro Tamaki
The one-step nucleic acid amplification (OSNA) assay was initially developed for the intraoperative assessment of sentinel lymph node metastases in breast cancer. This assay measures cytokeratin 19 (CK19) mRNA copy number and is widely used in hospitals. The results of the IBCSG 23-01, ACOSOG Z0011, and AMAROS trials demonstrated that no further axillary dissection is required for patients with sentinel lymph nodes that tested positive for cancer, which has led to a decreasing trend in the need for intraoperative assessment of lymph nodes...
August 22, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/26889144/how-effective-are-percutaneous-liver-directed-therapies-in-patients-with-non-colorectal-liver-metastases
#3
REVIEW
Thomas J Vogl, Ahmed Emam, Nagy N Naguib, Katrin Eichler, Stefan Zangos
BACKGROUND: The purpose of this review is to demonstrate the clinical indications, technical developments, and outcome of liver-directed therapies in interventional oncology of non-colorectal liver metastases. METHODS: Liver-directed therapies are classified into vascular transarterial techniques such as chemoperfusion (TACP), chemoembolization (TACE), radioembolization (selective internal radiation therapy (SIRT)), and chemosaturation, as well as thermal ablation techniques like microwave ablation (MWA), radiofrequency ablation (RFA), laser-induced thermotherapy (LITT), cryotherapy, and irreversible electroporation (IRE)...
December 2015: Viszeralmedizin
https://www.readbyqxmd.com/read/26889142/liver-resection-for-non-colorectal-liver-metastases-standards-and-extended-indications
#4
REVIEW
Ulf Kulik, Frank Lehner, Hüseyin Bektas, Jürgen Klempnauer
BACKGROUND: Due to the uncertain benefit of liver resection for non-colorectal liver metastases (NCLM), patient selection for surgery is generally difficult. Therefore, the aim of this article was to propose standard and extended indications for liver resection in this heterogeneous disease collective. METHODS: Review of the literature. RESULTS: The myriad of biologically different primary tumor entities as well as the mostly small and retrospective studies investigating the benefit of surgery for NCLM limits the proposal of general recommendations...
December 2015: Viszeralmedizin
https://www.readbyqxmd.com/read/26284141/golph3l-is-a-novel-prognostic-biomarker-for-epithelial-ovarian-cancer
#5
Yanling Feng, Fan He, Huini Wu, He Huang, Lan Zhang, Xian Han, Jihong Liu
OBJECTIVE: Golgi phosphoprotein 3 (GOLPH3) is a highly conserved membrane protein that is involved in a variety of cancers such as colorectal cancer, gastric cancer, ovarian cancer, and breast cancer. GOLPH3L is a paralog of GOLPH3. Although these proteins share a similar amino acid sequence, much less is known regarding the subcellular functions or effects of GOLPH3L on cancer compared with GOLPH3. The role of GOLPH3L in epithelial ovarian cancer (EOC) has not yet been investigated. METHODS: Using western blot, PCR and immunohistochemical analyses, we studied the clinical significance of GOLPH3L expression in EOC...
2015: Journal of Cancer
https://www.readbyqxmd.com/read/26077887/clinical-significance-of-glycoprotein-nonmetastatic-b-and-its-association-with-her2-in-breast-cancer
#6
Masako Kanematsu, Manabu Futamura, Masafumi Takata, Siqin Gaowa, Atsuko Yamada, Kasumi Morimitsu, Akemi Morikawa, Ryutaro Mori, Hideaki Hara, Kazuhiro Yoshida
Glycoprotein nonmetastatic B (GPNMB) is a potential oncogene that is particularly expressed in melanoma and breast cancer (BC). To clarify its clinical significance in BC, we measured serum GPNMB in vivo and investigated its cross talk with human epidermal growth factor 2 (HER2). GPNMB was expressed in four of six breast cell lines (SK-BR-3, BT-474, MDA-MD-231, and MDA-MD-157), two of six colorectal cell lines, and two of four gastric cancer (GC) cell lines. We established a GPNMB quantification system using enzyme-linked immunosorbent assay (ELISA) for these cell lines...
September 2015: Cancer Medicine
https://www.readbyqxmd.com/read/25247579/brain-metastases-in-gastrointestinal-cancers-is-there-a-role-for-surgery
#7
Johannes Lemke, Jan Scheele, Thomas Kapapa, Silvia von Karstedt, Christian Rainer Wirtz, Doris Henne-Bruns, Marko Kornmann
About 10% of all cancer patients will develop brain metastases during advanced disease progression. Interestingly, the vast majority of brain metastases occur in only three types of cancer: Melanoma, lung and breast cancer. In this review, we focus on summarizing the prognosis and impact of surgical resection of brain metastases originating from gastrointestinal cancers such as esophageal, gastric, pancreatic and colorectal cancer. The incidence of brain metastases is <1% in pancreatic and gastric cancer and <4% in esophageal and colorectal cancer...
2014: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/24058389/cancer-treatment-in-malawi-a-disease-of-palliation
#8
Claire E Kendig, Jonathan C Samuel, Anna F Tyson, Amal L Khoury, Laura P Boschini, Charles Mabedi, Bruce A Cairns, Carlos Varela, Carol G Shores, Anthony G Charles
BACKGROUND: Worldwide, new cancer cases will nearly double in the next 20 years while disproportionately affecting low and middle income countries (LMICs). Cancer outcomes in LMICs also remain bleaker than other regions of the world. Despite this, little is known about cancer epidemiology and surgical treatment in LMICs. To address this we sought to describe the characteristics of cancer patients presenting to the Surgery Department at Kamuzu Central Hospital in Lilongwe, Malawi. METHODS: We conducted a retrospective review of adult (18 years or older) surgical oncology services at Kamuzu Central Hospital in Lilongwe, Malawi from 2007 - 2010...
June 2013: World Journal of Oncology
https://www.readbyqxmd.com/read/23859447/the-influence-of-advanced-age-on-the-morbi-mortality-of-gastric-cancer-after-curative-surgery
#9
Araceli Mayol-Oltra, Roberto Marti-Obiol, Fernando López-Mozos, Gloria Báguena-Requena, Joaquín Ortega-Serrano
INTRODUCTION: gastric cancer (GC) is the fourth leading cause of cancer death in Spain after lung, colorectal, breast and prostate tumours. Surgery remains the only potentially curative treatment in localized gastric cancer. OBJECTIVE: the aim of our study is to evaluate and compare the clinical and surgical aspects, development of postoperative complications and outcomes of patients over 75 years old compared with younger patients in our centre. MATERIAL AND METHODS: comparative retrospective study, from March 2003 to June 2011...
April 2013: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/23815011/-prophylactic-surgery-in-common-hereditary-cancer-syndromes
#10
REVIEW
Catherine Noguès, Emmanuelle Mouret-Fourme
Preventive surgery is a mainstay of treatment for persons with genetic risk factors for cancer The indications of preventive surgery are based on a thorough risk assessment, clinical characteristics of the different hereditary cancer susceptibility syndromes, the types of mutation, and the possibility of watchful waiting for early cancer detection. Preventive surgery may either be recommended or represent one possible option. Bilateral prophylactic mastectomy can reduce the risk of breast cancer by up to 95% in BRCA1/BRCA2 mutation carriers...
October 2012: Bulletin de L'Académie Nationale de Médecine
https://www.readbyqxmd.com/read/23400546/identification-of-ros1-rearrangement-in-gastric-adenocarcinoma
#11
Jeeyun Lee, Seung Eun Lee, So Young Kang, In-Gu Do, Sujin Lee, Sang Yun Ha, Jeonghee Cho, Won Ki Kang, Jiryeon Jang, Sai-Hong Ignatius Ou, Kyoung-Mee Kim
BACKGROUND: Recently, chromosomal rearrangements involving receptor tyrosine kinases (RTKs) have been described in common epithelial malignancies, including nonsmall cell lung cancer (NSCLC), colorectal cancer, and breast cancer. One of these RTKs, c-ros oncogene 1, receptor tyrosine kinase (ROS1), has been identified as a driver mutation in NSCLC, because its inhibition by crizotinib, an anaplastic lymphoma receptor tyrosine kinase (ALK)/met proto-oncogene hepatocyte growth factor receptor (MET)/ROS1 inhibitor, led to significant tumor shrinkage in ROS1-rearranged NSCLC...
May 1, 2013: Cancer
https://www.readbyqxmd.com/read/22759383/ovarian-metastases-resection-from-extragenital-primary-sites-outcome-and-prognostic-factor-analysis-of-147-patients
#12
Wenhua Li, Huaying Wang, Jian Wang, Fangfang L V, Xiaodong Zhu, Zhonghua Wang
BACKGROUND: To explore the outcomes and prognostic factors of ovarian metastasectomy intervention on overall survival from extragenital primary cancer. METHODS: Patients with ovarian metastases from extragenital primary cancer confirmed by laparotomy surgery and ovarian metastases resection were retrospectively collected in a single institution during an 8-year period. A total of 147 cases were identified and primary tumor sites were colorectal region (49.0%), gastric (40...
2012: BMC Cancer
https://www.readbyqxmd.com/read/22582577/-development-of-minimal-residual-cancer-cell-research
#13
REVIEW
Hisae Iinuma, Toshiaki Watanabe
Micrometastases of cancer cells occur during the early stages of cancer or from minimal residual cancer cells with metastatic potential. Recent progress in measuring methods has enabled the detection of minimal residual cancer cells in areas such as circulating tumor cells (CTCs) in peripheral blood, disseminated tumor cells in bone marrow, and free tumor cells in lymph nodes and the peritoneal cavity. Recently, it has been reported that the phenotypes of CTCs are closely related to cancer stem cells, and thus they may be of interest as new biomarkers in cancer patients...
March 2012: Nihon Geka Gakkai Zasshi
https://www.readbyqxmd.com/read/22111334/establishment-of-regional-alliance-clinical-pathways-for-gastrointestinal-cancer-in-tokushima
#14
Shinya Morimoto, Mitsuo Shimada
PURPOSE: The maintenance of regional alliance clinical pathways for five cancers (lung, stomach, liver, large intestine, and breast) has been requested along with a readjustment of specific requirements for a plan to promote cancer control measures based on the Cancer Control Act. The aim of this study was to clarify the usefulness of regional alliance clinical pathways for cancer of the gastrointestinal tract in Tokushima Prefecture. METHODS: Subjects comprised patients with digestive organ cancer who had undergone surgery at Tokushima University Hopsital between April 2009 and March 2010...
September 2011: Fukuoka Igaku Zasshi, Hukuoka Acta Medica
https://www.readbyqxmd.com/read/22017790/decreased-levels-of-serum-glutathione-peroxidase-3-are-associated-with-papillary-serous-ovarian-cancer-and-disease-progression
#15
Deep Agnani, Olga Camacho-Vanegas, Catalina Camacho, Shashi Lele, Kunle Odunsi, Samantha Cohen, Peter Dottino, John A Martignetti
BACKGROUND: Glutathione peroxidase 3 (GPX3) is a selenocysteine-containing antioxidant enzyme that reacts with hydrogen peroxide and soluble fatty acid hydroperoxides, thereby helping to maintain redox balance within cells. Serum levels of GPX3 have been found to be reduced in various cancers including prostrate, thyroid, colorectal, breast and gastric cancers. Intriguingly, GPX3 has been reported to be upregulated in clear cell ovarian cancer tissues and thus may have implications in chemotherapeutic resistance...
2011: Journal of Ovarian Research
https://www.readbyqxmd.com/read/21991871/-radiofrequency-ablation-for-liver-metastases-mini-invasive-therapeutic-option-for-patients-with-unresecable-tumors
#16
C Cirimbei, V Prunoiu, M Marincaş, C Daha, S Cirimbei, I Stefan, C Man, E Brătucu, C Pantiş, S Rădoi, M Romoşan, C Diaconu, C Zamfir, D Nechita, L Coman
UNLABELLED: Radiofrequency ablations (RFA), a new therapeutic option for liver metastases, proceeded by open surgery or laparoscopic approach, provide an acceptable control of local tumor process, involved lower risks than resection surgery. OBJECTIVES: We analyzed this procedure, for classic indication in hepatic metastatic tumors, based on four years experience, focused on perioperative complications, recurrence rate and long distant evolution. METHOD: Between December 2006 and December 2010, 61 patients with liver metastases underwent RFA; 46 cases had metastatic lesions from colo-rectal cancer, 9 cases from breast cancer, 4 cases from gastric cancer and 2 cases from ovarian cancer...
July 2011: Chirurgia
https://www.readbyqxmd.com/read/21812503/targeted-therapies-for-gastric-cancer-current-status
#17
REVIEW
Jaclyn Yoong, Michael Michael, Trevor Leong
Gastric cancer represents one of the most common cancers internationally. Unfortunately the majority of patients still present at an advanced stage, and despite advances in diagnostic and treatment strategies, outcomes still remain poor with high mortality rates despite a decline in incidence. Whilst the utility of classical chemotherapy agents has been explored thoroughly (and continues to be investigated, alone or in various combinations), advances have been slow and the efficacy of these agents has reached a plateau...
July 30, 2011: Drugs
https://www.readbyqxmd.com/read/21461074/clinical-features-of-metastatic-tumors-of-the-pancreas-in-korea-a-single-center-study
#18
Won Jae Yoon, Ji Kon Ryu, Yong-Tae Kim, Yong Bum Yoon, Sun-Whe Kim, Woo Ho Kim
BACKGROUND/AIMS: The purpose of this study was to examine the clinical features of metastatic tumors of the pancreas (MTPs) in Korea. METHODS: A total of 53 cases (31 males) of pathologically proven MTPs were collected. Clinicopathological characteristics and patient outcomes were evaluated. RESULTS: The median age at the diagnosis of the MTP was 60 years. The median interval between the diagnoses of primary malignancy and MTP was 2.2 years...
March 2011: Gut and Liver
https://www.readbyqxmd.com/read/21348412/genetic-testing-and-prevention-of-hereditary-cancer-at-the-mmci-over-10-years-of-experience
#19
REVIEW
L Foretova, K Petrakova, M Palacova, R Kalabova, M Svoboda, M Navratilova, M Schneiderova, K Bolcak, E Krejci, L Drazan, M Mikova, J Hazova, P Vasickova, E Machackova
Hereditary cancer syndromes are frequently seen in young cancer patients and patients with a positive family history. Genetic testing is important for the identification of high-risk individuals, and for the early introduction of specialized preventive care or prophylactic surgeries. High-risk tumour suppressor genes (BRCA1 and BRCA2) and DNA repair genes (MLH1, MSH2 and MSH6) are responsible for a substantial part of hereditary breast, ovarian and colorectal cancer. Other hereditary cancers are seen less frequently, but genetic testing has increased for many other site-specific cancers and complex syndromes...
2010: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/21319152/gastrointestinal-cancer-and-brain-metastasis-a-rare-and-ominous-sign
#20
REVIEW
Pauline H Go, Zachary Klaassen, Michael C Meadows, Ronald S Chamberlain
Metastatic brain tumors represent 20% to 40% of all intracranial neoplasms and are found most frequently in association with lung cancer (50%) and breast cancer (12%). Although brain metastases occur in <4% of all tumors of the gastrointestinal (GI) tract, the incidence of GI brain metastasis is rising in part due to more effective systemic treatments and prolonged survival of patients with GI cancer. Data were collected from 25 studies (11 colorectal, 7 esophageal, 2 gastric, 1 pancreatic, 1 intestinal, 3 all-inclusive GI tract cancer) and 13 case reports (4 pancreatic, 4 gallbladder, and 5 small bowel cancer)...
August 15, 2011: Cancer
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