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https://www.readbyqxmd.com/read/29768636/water-related-mechanisms-proposed-for-storing-and-transmitting-homeopathic-information-putative-links-with-biological-responses
#1
José Roberto Pereira Guedes, Leoni Villano Bonamin, Vera Luiza Capelozzi
INTRODUCTION:  There are two critical pillars of homeopathy that contrast with the dominant scientific approach: the similitude principle and the potentization of serial dilutions. Three main hypotheses about the mechanisms of action are in discussion: nanobubbles-related hormesis; vehicle-related electric resonance; and quantum non-locality. OBJECTIVES:  The aim of this paper is to review and discuss some key points of such properties: the imprint of supramolecular structures based on the nanoparticle-allostatic, cross-adaptation-sensitization (NPCAS) model; the theory of non-molecular electromagnetic transfer of information, based on the coherent water domains model, and relying (like the NPCAS model) on the idea of local interactions; and the hypothesis of quantum entanglement, based on the concept of non-locality...
May 16, 2018: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/29742900/crowding-stabilizes-dmso-water-hydrogen-bonding-interactions
#2
Kwang-Im Oh, Carlos R Baiz
Up to 40% of intracellular water is confined due to the dense packing of macromolecules, ions, and osmolytes. Despite the large body of work concerning the effect of additives on biomolecular structure and stability, the role of crowding and heterogeneity is not well understood. Here, infrared spectroscopy and molecular dynamics simulations are used to describe the mechanisms by which crowding modulates hydrogen bonding interactions between water and dimethyl sulfoxide (DMSO). Specifically, we use formamide and dimethylformamide (DMF) as molecular crowders and show that S=O hydrogen bond populations in aqueous mixtures are increased by both amides...
May 9, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29725040/membrane-depolarization-and-aberrant-lipid-distributions-in-the-neonatal-rat-brain-following-hypoxic-ischaemic-insult
#3
Dominika Luptakova, Ladislav Baciak, Tomas Pluhacek, Anton Skriba, Blanka Sediva, Vladimir Havlicek, Ivo Juranek
Neonatal hypoxic-ischaemic (HI) encephalopathy is among the most serious complications in neonatology. In the present study, we studied the immediate (0 hour), subacute (36 hours) and late (144 hours) responses of the neonatal brain to experimental HI insult in laboratory rats. At the striatal level, the mass spectrometry imaging revealed an aberrant plasma membrane distribution of Na+ /K+ ions in the oedema-affected areas. The failure of the Na+ /K+ gradients was also apparent in the magnetic resonance imaging measurements, demonstrating intracellular water accumulation during the acute phase of the HI insult...
May 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29663711/dilution-of-oral-d-3-creatine-to-measure-creatine-pool-size-and-estimate-skeletal-muscle-mass-development-of-a-correction-algorithm
#4
Mahalakshmi Shankaran, Gregg Czerwieniec, Chancy Fessler, Po-Yin Anne Wong, Salena Killion, Scott M Turner, Marc K Hellerstein, William J Evans
BACKGROUND: Muscle mass can be measured directly in vivo by isotope dilution, using Creatine-(methyl-d3 ) monohydrate (D3 -Cr) by mouth followed by measurement of the steady-state enrichment of D3 -creatinine (D3 -Crn) in urine. Isotope dilution methods require knowledge of the amount of tracer delivered to the pool of interest. In a subset of human subjects, a small amount of orally administered D3 -Cr 'spills' into urine after absorption and prior to transport into skeletal muscle cells...
April 16, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29575414/evidence-for-the-role-of-intracellular-water-lifetime-as-a-tumour-biomarker-by-in-vivo-field-cycling-relaxometry
#5
Maria Rosaria Ruggiero, Simona Baroni, Stefania Pezzana, Gianni Ferrante, Simonetta Geninatti Crich, Silvio Aime
Through access to in vivo T1 measurements at low magnetic fields it was established that tumour cells display proton T1 values that are markedly longer than the those shown by healthy tissue. Moreover, it has been found that the elongation of T1 parallels the aggressiveness of the investigated tumour. The T1-lengthening is associated with an enhanced water exchange rate across the transcytolemmal membrane through an overexpression/upregulation of GLUT1 and Na+/K+ATPase transporters. It follows that the intracellular (IN) water lifetime represents a hallmark of tumour cells that can be easily monitored by measuring T1 at different magnetic field strengths ranging from 0...
March 25, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29574521/could-bioelectric-impedance-spectroscopy-bis-measured-appendicular-intracellular-water-serve-as-a-lean-mass-measurement-in-sarcopenia-definitions-a-pilot-study
#6
E Siglinsky, B Buehring, D Krueger, N Binkley, Y Yamada
DXA lean mass measurement for sarcopenia diagnosis is not always possible. Bioelectric impedance spectroscopy (BIS), a portable technology, is a potential alternative to DXA-measured lean mass. This pilot study explores the possibility and proposes an arbitrarily chosen potential cut-point for appendicular intracellular water corrected by height (aICW/ht2 ). INTRODUCTION: Sarcopenia definitions often include DXA lean mass measurement. However, DXA is not always available. We explored the potential of a less-expensive mobile method, bioelectric impedance spectroscopy (BIS), to assess lean mass for sarcopenia determination...
March 25, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29565159/correlation-between-skinfold-thickness-and-bioelectrical-impedance-analysis-for-the-evaluation-of-body-composition-in-patients-on-dialysis
#7
Ana Laura Flores-García, Carmen Alicia Sánchez-Ramírez, Óscar Alberto Newton-Sánchez, Fabián Rojas-Larios
INTRODUCTION: Patients on dialysis have important changes in body composition. OBJECTIVES: To determine the correlation between skinfold thickness (SKF) and bioimpedance analysis (BIA) for estimating fat mass (FM) and lean body mass (LBM) in patients undergoing hemodialysis (HD) and peritoneal dialysis (PD). METHODS: Cross-sectional study. We included 50 patients under dialysis treatment. To measure SKF, we used the Lange® skinfold caliper (Beta Technology, California, USA) and we carried out the impedance analysis with the Bodystat Quadscan 4000® (Quadscan, Isle of Man, UK)...
January 10, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29535377/bioimpedance-defined-overhydration-predicts-survival-in-end-stage-kidney-failure-eskf-systematic-review-and-subgroup-meta-analysis
#8
Matthew Tabinor, Emma Elphick, Michael Dudson, Chun Shing Kwok, Mark Lambie, Simon J Davies
Both overhydration and comorbidity predict mortality in end-stage kidney failure (ESKF) but it is not clear whether these are independent of one another. We undertook a systematic review of studies reporting outcomes in adult dialysis patients in which comorbidity and overhydration, quantified by whole body bioimpedance (BI), were reported. PubMed, EMBASE, PsychInfo and the Cochrane trial database were searched (1990-2017). Independent reviewers appraised studies including methodological quality (assessed using QUIPS)...
March 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29531529/pre-and-postoperative-body-composition-and-metabolic-characteristics-in-patients-with-acromegaly-a-prospective-study
#9
Xiaopeng Guo, Lu Gao, Xiaodong Shi, Hailong Li, Qiang Wang, Zihao Wang, Wei Chen, Bing Xing
Objective: To investigate the preoperative body composition, metabolic characteristics, and postoperative changes in patients with active acromegaly and analyze the effects of gender and age. Methods: We included 36 patients with untreated acromegaly and 37 patients with nonfunctional pituitary adenomas. Adipose tissue (AT), the visceral fat index (VFI), sclerotin, protein, skeletal muscle, total body water (TBW), intracellular water (ICW), and extracellular water (ECW) were measured using bioelectrical impedance analysis (BIA)...
2018: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29516549/cest-mri-studies-of-cells-loaded-with-lanthanide-shift-reagents
#10
Giuseppe Ferrauto, Enza Di Gregorio, Daniela Delli Castelli, Silvio Aime
PURPOSE: Magnetic resonance imaging has been used extensively to track in vivo implanted cells that have been previously labeled with relaxation enhancers. However, this approach is not suitable to track multiple cell populations, as it may lead to confounding results in case the contrast agent is released from the labeled cells. This paper demonstrates how the use of CEST agents can overcome these issues. After encapsulating paramagnetic lanthanide shift reagents, we may shift the absorption frequency of the intracellular water resonance (δIn ), thus generating frequency-encoding CEST responsive cells that can be visualized in the MR image by applying the proper RF irradiation...
March 7, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29471000/relationship-between-cerebrospinal-fluid-concentrations-of-orexin-a-hypocretin-1-and-body-composition-in-humans
#11
João C P Santiago, Markus Otto, Werner Kern, Paul Christian Baier, Manfred Hallschmid
The hypothalamic neuropeptide orexin A (hypocretin-1) is a key signal in sleep/wake regulation and promotes food intake. We investigated the relationship between cerebrospinal fluid orexin A concentrations and body composition in non-narcoleptic human subjects with a wide range of body weight to gain insight into the role of orexin A in human metabolism. We collected cerebrospinal fluid and blood samples and measured body composition by bioelectric impedance analysis in 36 subjects (16 women and 20 men) with body mass indices between 16...
April 2018: Peptides
https://www.readbyqxmd.com/read/29420149/muscle-glycogen-depletion-does-not-alter-segmental-extracellular-and-intracellular-water-distribution-measured-using-bioimpedance-spectroscopy
#12
Keisuke Shiose, Yosuke Yamada, Keiko Motonaga, Hideyuki Takahashi
Although each gram of glycogen is well known to bind 2.7-4.0 g of water, no studies have been conducted on the effect of muscle glycogen depletion on body water distribution. We investigated changes in extracellular and intracellular water (ECW and ICW) distribution in each body segment in muscle glycogen-depletion and glycogen-recovery condition using segmental bioimpedance spectroscopy technique (BIS). Twelve male subjects consumed 7.0 g.kg body mass-1 of indigestible (glycogen-depleted group) or digestible (glycogen-recovered group) carbohydrate for 24 hours after a glycogen-depletion cycling exercise...
February 8, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29402371/-assessing-nutritional-status-of-severe-malnutrition-patients-by-bioelectrical-impedance-technique-a-multicenter-prospective-study
#13
Qiang Li, Xueni Li, Yuxin Leng, Xi Zhu, Gaiqi Yao
OBJECTIVE: To assess the nutritional status of severe malnutrition patients with anorexia nervosa by multi-frequency bioelectrical impedance technique, and to provide the basis for nutritional support therapy. METHODS: A prospective study was conducted. Twenty-six severe malnutrition patients with anorexia nervosa, body mass index (BMI) ≤ 16 kg/m2 admitted to intensive care unit (ICU) of Peking University Third Hospital and general three ward of Peking University Sixth Hospital from June 1st to September 30th, 2017 were enrolled...
February 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29373702/tissue-specific-changes-in-apoplastic-proteins-and-cell-wall-structure-during-cold-acclimation-of-winter-wheat-crowns
#14
Ian R Willick, Daisuke Takahashi, D Brian Fowler, Matsuo Uemura, Karen K Tanino
The wheat (Triticum aestivum L.) crown is the critical organ of low temperature stress survival over winter. In cold-acclimated crowns, ice formation in the apoplast causes severe tissue disruption as it grows at the expense of intracellular water. While previous crown studies have shown the vascular transition zone (VTZ) to have a higher freezing sensitivity than the shoot apical meristem (SAM), the mechanism behind the differential freezing response is not fully understood. Cooling cold-acclimated crowns to -10 °C resulted in an absence of VTZ tetrazolium chloride staining, whereas the temperatures at which 50% of the SAM stained positive and 50% of plants recovered (LT50) were similar after cold acclimation for 21 (-16 °C) and 42 d (-20 °C) at 4 °C...
January 24, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29370428/the-effect-of-high-volume-online-haemodiafiltration-on-nutritional-status-and-body-composition-the-protein-stores-preservation-peset-study
#15
Pablo Molina, Belén Vizcaíno, Mariola D Molina, Sandra Beltrán, Mercedes González-Moya, Antonio Mora, Cristina Castro-Alonso, Julia Kanter, Ana I Ávila, José L Górriz, Nuria Estañ, Luis M Pallardó, Denis Fouque, Juan J Carrero
Background: Compared with conventional haemodialysis (HD), online haemodiafiltration (OL-HDF) achieves a more efficient removal of uraemic toxins and reduces inflammation, which could favourably affect nutritional status. We evaluate the effect of OL-HDF on body composition and nutritional status in prevalent high-flux HD (HF-HD) patients. Methods: In all, 33 adults with chronic kidney disease (CKD) Stage 5 undergoing maintenance HF-HD were assigned to post-dilution OL-HDF (n = 17) or to remain on HF-HD (n = 16, control group) for 12 months...
January 22, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29338044/probing-the-changes-in-gene-expression-due-to-%C3%AE-crystallin-mutations-in-mouse-models-of-hereditary-human-cataract
#16
Usha P Andley, Eric Tycksen, Brittney N McGlasson-Naumann, Paul D Hamilton
The mammalian eye lens expresses a high concentration of crystallins (α, β and γ-crystallins) to maintain the refractive index essential for lens transparency. Crystallins are long-lived proteins that do not turnover throughout life. The structural destabilization of crystallins by UV exposure, glycation, oxidative stress and mutations in crystallin genes leads to protein aggregation and development of cataracts. Several destabilizing mutations in crystallin genes are linked with human autosomal dominant hereditary cataracts...
2018: PloS One
https://www.readbyqxmd.com/read/29212765/changes-in-the-fluid-volume-balance-between-intra-and-extracellular-water-in-a-sample-of-japanese-adults-aged-15-88-years-old-a-cross-sectional-study
#17
Yasushi Ohashi, Nobuhiko Joki, Keisuke Yamazaki, Takeshi Kawamura, Reibin Tai, Hideyo Oguchi, Rena Yuasa, Ken Sakai
The fluid volume balance between intracellular water (ICW) and extracellular water (ECW) gradually changes with age and various medical conditions. Comprehension of these physiological changes would aid in clinical decision-making related to body fluid assessments. A total of 1,992 individuals (753 men and 1,239 women) aged {greater than or equal to}15 years included in this study had their body composition measurements performed at training gyms in 2014. We developed a regression formula to assess the association of age with the ratio of ECW to ICW in these subjects...
December 6, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29198074/comparison-of-muscle-lean-mass-measurement-methods-correlation-with-functional-and-biochemical-testing
#18
B Buehring, E Siglinsky, D Krueger, W Evans, M Hellerstein, Y Yamada, N Binkley
DXA-measured lean mass is often used to assess muscle mass but has limitations. Thus, we compared DXA lean mass with two novel methods-bioelectric impedance spectroscopy and creatine (methyl-d3) dilution. The examined methodologies did not measure lean mass similarly and the correlation with muscle biomarkers/function varied. INTRODUCTION: Muscle function tests predict adverse health outcomes better than lean mass measurement. This may reflect limitations of current mass measurement methods...
March 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29182426/effects-of-single-set-resistance-training-with-different-frequencies-on-a-cellular-health-indicator-in-older-women
#19
Alex S Ribeiro, Matheus A Nascimento, Brad J Schoenfeld, João Pedro Nunes, Andreo F Aguiar, Edilaine F Cavalcante, Analiza M Silva, Luís B Sardinha, Steven J Fleck, Edilson S Cyrino
The main purpose of this study was compare the effects of resistance training (RT) performed two versus three times per week on phase angle (a cellular health indicator) in older women. Thirty-nine women (69.1±5.5 years) were randomly assigned to perform a RT program two (G2X) or three (G3X) days per week for 12 weeks. The RT was a whole-body program (8 exercises, 1 set, 10-15 repetitions). Phase angle, resistance, reactance, and total body water were assessed by bioimpedance spectroscopy. Intracellular water, reactance, and phase angle increased significantly in G2X (2...
November 28, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/29176686/the-dynamics-of-intracellular-water-constrains-glycolytic-oscillations-in-saccharomyces-cerevisiae
#20
Henrik S Thoke, Sigmundur Thorsteinsson, Roberto P Stock, Luis A Bagatolli, Lars F Olsen
We explored the dynamic coupling of intracellular water with metabolism in yeast cells. Using the polarity-sensitive probe 6-acetyl-2-dimethylaminonaphthalene (ACDAN), we show that glycolytic oscillations in the yeast S. cerevisiae BY4743 wild-type strain are coupled to the generalized polarization (GP) function of ACDAN, which measures the physical state of intracellular water. We analysed the oscillatory dynamics in wild type and 24 mutant strains with mutations in many different enzymes and proteins. Using fluorescence spectroscopy, we measured the amplitude and frequency of the metabolic oscillations and ACDAN GP in the resting state of all 25 strains...
November 24, 2017: Scientific Reports
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