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Anthocyanin, regulation

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https://www.readbyqxmd.com/read/29344660/purple-sweet-potato-color-attenuates-high-fat-induced-neuroinflammation-in-mouse-brain-by-inhibiting-mapk-and-nf-%C3%AE%C2%BAb-activation
#1
Jian Li, Zhao Shi, Yongjie Mi
Purple sweet potato color (PSPC) is a natural anthocyanin pigment that is derived from purple sweet potato storage roots. PSPC possesses a variety of biological activities, including antioxidant, anti‑inflammatory and neuroprotective effects; however, the detailed effects of PSPC on high‑fat diet (HFD)‑induced neuroinflammation remain to be determined. The aim of the present study was to investigate whether PSPC has a protective role in HFD‑associated neuroinflammation in the mouse brain and to provide novel insight into the mechanisms of the action...
January 17, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29336479/inhibition-of-glycolytic-metabolism-in-glioblastoma-cells-by-pt3glc-combinated-with-pi3k-inhibitor-via-sirt3-mediated-mitochondrial-and-pi3k-akt-mapk-pathway
#2
Gang Wang, Xing-Li Fu, Jun-Jie Wang, Rui Guan, Yan Sun, Shing-Shun Tony To
Glioblastoma multiforme (GBM) is the most malignant and aggressive glioma with abnormal expression of genes that mediate glycolytic metabolism and tumor cell growth. Petunidin-3-O- glucoside (Pt3glc) is a kind of anthocyanin in the red grape and derived beverages, representing the most common naturally occurring anthocyanins with a reduced incidence of cancer and heart diseases. In this study, whether Pt3glc could effectively regulate glycolysis to inhibit GBM cell was investigated by using the DBTRG-05MG cell lines...
January 16, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29332189/the-arabidopsis-histone-chaperone-fact-is-required-for-stress-induced-expression-of-anthocyanin-biosynthetic-genes
#3
Alexander Pfab, Matthias Breindl, Klaus D Grasser
The histone chaperone FACT is involved in the expression of genes encoding anthocyanin biosynthetic enzymes also upon induction by moderate high-light and therefore contributes to the stress-induced plant pigmentation. The histone chaperone FACT consists of the SSRP1 and SPT16 proteins and associates with transcribing RNAPII (RNAPII) along the transcribed region of genes. FACT can promote transcriptional elongation by destabilising nucleosomes in the path of RNA polymerase II, thereby facilitating efficient transcription of chromatin templates...
January 13, 2018: Plant Molecular Biology
https://www.readbyqxmd.com/read/29329832/effects-of-cluster-thinning-on-vine-photosynthesis-berry-ripeness-and-flavonoid-composition-of-cabernet-sauvignon
#4
Yu Wang, Yan-Nan He, Wei-Kai Chen, Fei He, Wu Chen, Xiao-Dong Cai, Chang-Qing Duan, Jun Wang
Cluster thinning is a common practice for regulating vine yield and grape quality. The effects of cluster thinning on vine photosynthesis, berry ripeness and flavonoid composition of V. vinifera L. Cabernet Sauvignon were evaluated during two seasons. Half of the clusters were removed at pea-size and veraison relative to two controls, respectively. Both cluster thinning treatments significantly increased pruning weight and decreased yield. No effects of cluster thinning on berry growth, ripeness and flavonol composition were observed...
May 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29328429/anthocyanins-inhibit-high-glucose-induced-renal-tubular-cell-apoptosis-caused-by-oxidative-stress-in-db-db-mice
#5
Jinying Wei, Haijiang Wu, Haiqiang Zhang, Fang Li, Shurui Chen, Baohua Hou, Yonghong Shi, Lijuan Zhao, Huijun Duan
Oxidative stress is an important contributory factor resulting the development of kidney injury in patients with diabetes. Numerous in vitro and in vivo studies have suggested that anthocyanins, natural phenols commonly existing in numerous fruits and vegetables, exhibit important antioxidative, anti‑inflammatory and antihyperlipidemic effects; however, their effects and underlying mechanisms on diabetic nephropathy (DN) have not yet been fully determined. In the present study, the regulation of apoptosis metabolism and antioxidative effects exhibited by anthocyanins [grape seed procyanidin (GSPE) and cyanidin‑3‑O‑β‑glucoside chloride (C3G)] were investigated, and the molecular mechanism underlying this process was investigated in vivo and in vitro...
January 10, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29315918/a-peroxisomal-thioesterase-plays-auxiliary-roles-in-plant-%C3%AE-oxidative-benzoic-acid-metabolism
#6
Funmilayo Adebesin, Joshua R Widhalm, Joseph H Lynch, Rachel M McCoy, Natalia Dudareva
Peroxisomal β-oxidative degradation of compounds is a common metabolic theme in eukaryotes. Reported benzoyl-CoA (BA-CoA) thioesterase activity in peroxisomes from petunia flowers suggests that, like mammals and fungi, plants contain auxiliary enzymes mediating β-oxidation. Here, we report identification of Petunia hybrida Thioesterase 1 (PhTE1), which catalyzes hydrolysis of aromatic acyl-CoAs to their corresponding acids in peroxisomes. PhTE1 expression is spatially, developmentally and temporally regulated and exhibits a similar pattern to known benzenoid metabolic genes...
January 6, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29315644/solar-uv-light-regulates-flavonoid-metabolism-in-apple-malus-x-domestica
#7
Rebecca A Henry-Kirk, Blue Plunkett, Miriam Hall, Tony McGhie, Andrew C Allan, Jason J Wargent, Richard V Espley
Ultraviolet-B light (UV-B) is one environmental signal perceived by plants that affects the flavonoid pathway and influences the levels of anthocyanins, flavonols and proanthocyanidins. To understand the mechanisms underlying UV exposure, apple trees were grown under spectral filters that altered transmission of solar UV light. Fruit analysis showed that UV induced changes in physiology, metabolism and gene expression levels during development over a season. These changes were sustained after storage. Under low UV ripening was delayed, fruit size decreased, and anthocyanin and flavonols were reduced...
January 6, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29315208/exogenous-24-epibrassinolide-interacts-with-light-to-regulate-anthocyanin-and-proanthocyanidin-biosynthesis-in-cabernet-sauvignon-vitis-vinifera-l
#8
Yali Zhou, Chunlong Yuan, Shicheng Ruan, Zhenwen Zhang, Jiangfei Meng, Zhumei Xi
Anthocyanins and proanthocyanidins (PAs) are crucial factors that affect the quality of grapes and the making of wine, which were stimulated by various stimuli and environment factors (sugar, hormones, light, and temperature). The aim of the study was to investigate the influence of exogenous 24-Epibrassinolide (EBR) and light on the mechanism of anthocyanins and PAs accumulation in grape berries. Grape clusters were sprayed with EBR (0.4 mg/L) under light and darkness conditions (EBR + L, EBR + D), or sprayed with deionized water under light and darkness conditions as controls (L, D), at the onset of veraison...
January 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29297687/anthocyanin-management-in-fruits-by-fertilization
#9
Mareike Jezek, Christian Zörb, Nikolaus Merkt, Christoph-Martin Geilfus
Anthocyanins are water-soluble vacuolar plant pigments that are mainly synthesized in epidermal layers and the flesh of fruits such as apples, cherries, grapes, and other berries. Because of their attractive red to purple coloration and their health-promoting potential, anthocyanins are significant determinants for the quality and market value of fruits and fruit-derived products. In crops, anthocyanin accumulation in leaves can be caused by nutrient deficiency which is usually ascribed to insufficient nitrogen or phosphorous fertilization...
January 3, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29297327/the-factors-affecting-the-evolution-of-the-anthocyanin-biosynthesis-pathway-genes-in-monocot-and-dicot-plant-species
#10
Olesya Yu Shoeva, Anastasiya Yu Glagoleva, Elena K Khlestkina
BACKGROUND: The available data demonstrate that even in universal metabolic pathways, some species-specific regulatory features of structural genes are present. For instance, in the anthocyanin biosynthesis pathway (ABP), genes may be regulated by ABP-specific regulatory factors, and their expression levels may be strongly associated with anthocyanin pigmentation, or they may be expressed independently of pigmentation. A dataset of orthologous ABP genes (Chs, Chi, F3h, F3'h, Dfr, Ans) from monocot and dicot plant species that have distinct gene regulation patterns and different types of pollination was constructed to test whether these factors affect the evolution of the genes...
December 28, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29278211/engineering-the-nutraceutical-and-cosmeceutical-potential-of-two-cultivars-of-rubus-fruticosus-l-by-different-cultivation-conditions
#11
Maria Papaioanou, Evangelia Chronopoulou, Gheorghii Ciobotari, Rodica Efrose, Liliana Sfichi-Duke, Marianna Chatzikonstantinou, Evangelia Pappa, Ioannis Ganopoulos, Panagiotis Madesis, Irini Nianiou-Obeidat, Taofen Zeng, Nikolaos E Labrou
BACKGROUND: The starting point for the development of new, functional products derived from Rubus fruticosus L. is to determine the optimal cultivation conditions that produce maximal yield of fruits containing desirable bioactive properties. Towards that goal, the effect of soil, soil/peat mixture and light intensity on the nutraceutical and cosmeceutical potential of two cultivars ('Thornfree' and 'Loch Ness') of Rubus fruticosus L. were evaluated. 'Thornfree' cultivar produced fruits in all light conditions, while 'Loch Ness' did not produce fruits in low light conditions...
December 26, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29273740/rna-sequencing-provides-insights-into-the-evolution-of-lettuce-and-the-regulation-of-flavonoid-biosynthesis
#12
Lei Zhang, Wenqing Su, Rong Tao, Weiyi Zhang, Jiongjiong Chen, Peiyao Wu, Chenghuan Yan, Yue Jia, Robert M Larkin, Dean Lavelle, Maria-Jose Truco, Sebastian Reyes Chin-Wo, Richard W Michelmore, Hanhui Kuang
Different horticultural types of lettuce exhibit tremendous morphological variation. However, the molecular basis for domestication and divergence among the different horticultural types of lettuce remains unknown. Here, we report the RNA sequencing of 240 lettuce accessions sampled from the major horticultural types and wild relatives, generating 1.1 million single-nucleotide polymorphisms (SNPs). Demographic modeling indicates that there was a single domestication event for lettuce. We identify a list of regions as putative selective sweeps that occurred during domestication and divergence, respectively...
December 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/29258257/aetmyc1-the-candidate-gene-controlling-the-red-coleoptile-trait-in-aegilops-tauschii-coss-accession-as77
#13
Dong Cao, Guangji Ye, Yuan Zong, Bo Zhang, Wenjie Chen, Baolong Liu, Huaigang Zhang
The red coleoptile trait can help monocotyledonous plants withstand stresses, and key genes responsible for the trait have been isolated from Triticum aestivum, Triticum urartu, and Triticum monococcum, but no corresponding research has been reported for Aegilops tauschii. In this research, transcriptome analysis was performed to isolate the candidate gene controlling the white coleoptile trait in Ae. tauschii. There were 5348 upregulated, differentially-expressed genes (DEGs) and 4761 downregulated DEGs in red coleoptile vs...
December 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29244752/proteomic-analysis-reveals-coordinated-regulation-of-anthocyanin-biosynthesis-through-signal-transduction-and-sugar-metabolism-in-black-rice-leaf
#14
Linghua Chen, Yining Huang, Ming Xu, Zuxin Cheng, Jingui Zheng
Black rice (Oryza sativa L.) is considered to be a healthy food due to its high content of anthocyanins in the pericarp. The synthetic pathway of anthocyanins in black rice grains has been identified, however, the proteomic profile of leaves during grain development is still unclear. Here, isobaric Tags Relative and Absolute Quantification (iTRAQ) MS/MS was carried out to identify statistically significant changes of leaf proteome in the black rice during grain development. Throughout three sequential developmental stages, a total of 3562 proteins were detected and 24 functional proteins were differentially expressed 3-10 days after flowering (DAF)...
December 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29241070/protocatechuic-acid-ameliorates-high-glucose-induced-extracellular-matrix-accumulation-in-diabetic-nephropathy
#15
Yali Ma, Fang Chen, Suxia Yang, Baoping Chen, Jun Shi
Protocatechuic acid (PCA), a phenolic compound of anthocyanins, was reported to possess various pharmacologic properties, including anti-oxidant, anti-inflammatory, anti-apoptosis, anti-diabetic and anti-tumor activities. However, the role of PCA in diabetic nephropathy remains elusive. The present study was conducted to evaluate the effects of PCA on extracellular matrix (ECM) accumulation in high glucose (HG)-induced human mesangial cells (MCs) and explore the possible mechanism. Our results demonstrated that PCA obviously inhibited HG-induced proliferation of MCs in a dose-dependent manner...
December 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29240311/systemic-changes-in-photosynthesis-and-ros-homeostasis-in-shoots-of-arabidopsis-thaliana-infected-with-beet-cyst-nematode-heterodera-schachtii
#16
Mateusz Labudda, Elżbieta Różańska, Weronika Czarnocka, Mirosław Sobczak, Jolanta Maria Dzik
Photosynthetic efficiency and redox homeostasis are important for plant physiological processes during regular development as well as defence responses. The second-stage juveniles of the Heterodera schachtii, induce syncytial feeding sites in host roots. To ascertain whether development of the syncytia alters photosynthesis and metabolism of ROS, chlorophyll a fluorescence measurements and antioxidant responses were studied in Arabidopsis thaliana shoots at the day of inoculation and at 3, 7 and 15 days post-inoculation (dpi)...
December 14, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29235191/the-effect-of-cyanidin-3-o-glucoside-on-uva-induced-damage-in-human-dermal-fibroblasts
#17
Shi Wu, Yunfeng Hu, Zhen Li, Weibin Bai, Jiayi Zhao, Cuiqin Huang, Qin Li, Chongzhu Fan, Liehua Deng, Daxiang Lu
BACKGROUND/PURPOSE: Ultraviolet-A (UVA) radiation can induce photoaging and skin cancer, but means to prevent or treat UVA-induced skin damage require further study. We investigated the effects of cyanidin-3-o-glucoside (C3G), a monomer of anthocyanin, on UVA-induced damage in primary human dermal fibroblasts (HDFs), and we identify possible mechanisms underlying the protective effects of this compound. METHODS: Primary HDFs were pretreated with 80 μM C3G for 2 h and UVA irradiated at 12 J/cm2 ...
December 13, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29232522/molecular-analysis-of-anthocyanin-related-genes-in-ornamental-cabbage
#18
Si-Won Jin, Md Abdur Rahim, Hoy-Taek Kim, Jong-In Park, Jong-Goo Kang, Ill-Sup Nou
Ornamental cabbage (Brassica oleracea var. acephala) is a winter-grown and important decorative plant of the Brassicaceae family, which displays an exceptional coloration in the central leaves of the rosette. Anthocyanins are the key determinant of the red, purple and blue colors of vegetative and reproductive parts of many plant species including ornamental cabbage. Total anthocyanin content was measured spectrophotometrically and the highest anthocyanin content detected in the red followed by light-red and white ornamental cabbage lines...
December 12, 2017: Genome Génome / Conseil National de Recherches Canada
https://www.readbyqxmd.com/read/29230174/pelargonidin-modulates-keap1-nrf2-pathway-gene-expression-and-ameliorates-citrinin-induced-oxidative-stress-in-hepg2-cells
#19
G R Sharath Babu, Tamatam Anand, N Ilaiyaraja, Farhath Khanum, N Gopalan
Pelargonidin chloride (PC) is one of the major anthocyanin found in berries, radish and other natural foods. Many natural chemopreventive compounds have been shown to be potent inducers of phase II detoxification genes and its up-regulation is important for oxidative stress related disorders. In the present study, we investigated the effect of PC in ameliorating citrinin (CTN) induced cytotoxicity and oxidative stress. The cytotoxicity of CTN was evaluated by treating HepG2 (Human hepatocellular carcinoma) cells with CTN (0-150 μM) in a dose dependent manner for 24 h, and the IC50 was determined to be 96...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29228569/the-effects-of-blueberry-anthocyanins-on-histone-acetylation-in-rat-liver-fibrosis
#20
Wei Zhan, Xin Liao, Ru-Jia Xie, Tian Tian, Lei Yu, Xing Liu, Jing Liu, Po Li, Bing Han, Ting Yang, Bei Zhang, Li-Jun Cai, Rui Li, Qin Yang
To determine the effects ofanthocyanins from blueberries on hepatic stellate cell (HSCs-T6) and on histone acetylation during liver fibrosis induced by CCl4 in rats. Fifty male SD rats weighing 180 ± 20g were randomly placed into a control group, a hepatic fibrosis group, a blueberry treatment group, a blueberry intervention group, and a natural recovery group. After the rats were sacrificed, the livers and the liver indexes were measured, and the pathological changes were observed by HE staining and Masson staining...
November 14, 2017: Oncotarget
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