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https://www.readbyqxmd.com/read/28930939/preventing-mistransfusions-an-evaluation-of-institutional-knowledge-and-a-response
#1
Nickolas MacDougall, Fanglong Dong, Latoya Broussard, Mark E Comunale
BACKGROUND: Blood product mistransfusions occur when a process error causes transfusion of incompatible blood products. These events are known sources of negative patient outcomes. One such event demonstrated an institutional knowledge gap and an opportunity to reduce this source of transfusion errors. The focus of this study was to evaluate the application of point of care cognitive aids to bridge potentially lethal knowledge gaps in blood product to patient compatibility. METHODS: A patient-donor ABO antigen compatibility grid for red blood cells (RBC) and fresh frozen plasma (FFP) was developed for creation of a cognitive aid and a blood product safety quiz...
September 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28930785/patients-and-clinicians-views-of-the-psychological-components-of-tinnitus-treatment-that-could-inform-audiologists-usual-care-a-delphi-survey
#2
Dean M Thompson, John Taylor, Deborah A Hall, Dawn-Marie Walker, Mary McMurran, Amanda Casey, David Stockdale, Debbie Featherstone, Derek J Hoare
OBJECTIVES: The aim of this study was to determine which components of psychological therapies are most important and appropriate to inform audiologists' usual care for people with tinnitus. DESIGN: A 39-member panel of patients, audiologists, hearing therapists, and psychologists completed a three-round Delphi survey to reach consensus on essential components of audiologist-delivered psychologically informed care for tinnitus. RESULTS: Consensus (≥80% agreement) was reached on including 76 of 160 components...
September 19, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28930760/medical-education-and-health-care-delivery-a-call-to-better-align-goals-and-purposes
#3
David P Sklar, Paul A Hemmer, Steven J Durning
The transformation of the U.S. health care system is under way, driven by the needs of an aging population, rising health care spending, and the availability of health information. However, the speed and effectiveness of the transformation of health care delivery will depend, in large part, upon engagement of the health professions community and changes in clinicians' practice behaviors. Current efforts to influence practice behaviors emphasize changes in the health payment system with incentives to move from fee-for-service to alternative payment models...
September 14, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28930751/dementia-predicting-cognitive-risk-score-and-its-correlation-with-cortical-thickness-in-parkinson-disease
#4
Byoung Seok Ye, Seun Jeon, Jee Hyun Ham, Jae Jung Lee, Jong Min Lee, Hye Sun Lee, Phil Hyu Lee, Young H Sohn
BACKGROUND: We developed a risk score system to predict risks of developing dementia in individual Parkinson disease (PD) patients using baseline neuropsychological tests. METHODS: A total of 216 nondemented PD patients underwent a baseline neuropsychological evaluation and were followed up for a mean of 2.7 (±1.1) years. Univariate Cox regression models controlled for age, gender, and education selected neuropsychological tests individually predicting dementia risk...
September 21, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28930592/choline-the-brain-and-neurodegeneration-insights-from-epigenetics
#5
Rola A Bekdash
  Neurodegenerative disorders are a major public health problem worldwide with huge socioeconomic effect. Recent evidence suggests that neurodegeneration is not only caused by genetic factors but also affected by environmental factors including nutrients. Environmental influences have been shown to cause epigenetic modifications in the brain with long-lasting effects on behavior if they occur in early life. It has been suggested that early nutritional intervention that includes choline, betaine, VitB6, VitB12 and/or folic acid could attenuate decline in cognitive functions...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930544/neural-signatures-of-attention-insights-from-decoding-population-activity-patterns
#6
Panagiotis Sapountzis, Georgia G Gregoriou
Understanding brain function and the computations that individual neurons and neuronal ensembles carry out during cognitive functions is one of the biggest challenges in neuroscientific research. To this end, invasive electrophysiological studies have provided important insights by recording the activity of single neurons in behaving animals. To average out noise, responses are typically averaged across repetitions and across neurons that are usually recorded on different days. However, the brain makes decisions on short time scales based on limited exposure to sensory stimulation by interpreting responses of populations of neurons on a moment to moment basis...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28929971/medisyn-uncertainty-aware-visualization-of-multiple-biomedical-datasets-to-support-drug-treatment-selection
#7
Chen He, Luana Micallef, Zia-Ur-Rehman Tanoli, Samuel Kaski, Tero Aittokallio, Giulio Jacucci
BACKGROUND: Dispersed biomedical databases limit user exploration to generate structured knowledge. Linked Data unifies data structures and makes the dispersed data easy to search across resources, but it lacks supporting human cognition to achieve insights. In addition, potential errors in the data are difficult to detect in their free formats. Devising a visualization that synthesizes multiple sources in such a way that links between data sources are transparent, and uncertainties, such as data conflicts, are salient is challenging...
September 13, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28929833/the-alzheimer-s-disease-metabolic-brain-pattern-in-mild-cognitive-impairment
#8
Sanne K Meles, Marco Pagani, Dario Arnaldi, Fabrizio De Carli, Barbara Dessi, Silvia Morbelli, Gianmario Sambuceti, Cathrine Jonsson, Klaus L Leenders, Flavio Nobili
We investigated the expression of the Alzheimer's disease-related metabolic brain pattern (ADRP) in (18)F-FDG-PET scans of 44 controls, 27 patients with mild cognitive impairment (MCI) who did not convert to Alzheimer's disease (AD) after five or more years of clinical follow-up, 95 MCI patients who did develop AD dementia on clinical follow-up, and 55 patients with mild-to-moderate AD. The ADRP showed good sensitivity (84%) and specificity (86%) for MCI-converters when compared to controls, but limited specificity when compared to MCI non-converters (66%)...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28929475/-mild-behavioural-impairment-as-an-antecedent-of-dementia-presentation-of-the-diagnostic-criteria-and-the-spanish-version-of-the-mbi-c-scale-for-its-evaluation
#9
REVIEW
L F Aguera-Ortiz, J Lopez-Alvarez, L Del Nido-Varo, E Soria Garcia-Rosel, D A Perez-Martinez, Z Ismail
INTRODUCTION: Neuropsychiatric symptoms are common in dementia and also in previous stages such as mild cognitive impairment. Their presence is related to greater conversion to dementia in cognitively healthy people or with mild cognitive impairment compared to those who do not suffer them. AIM: An international working group pertaining to the Alzheimer Association has proposed the concept of 'mild behavioral impairment' (MBI) to identify patients with mild neuropsychiatric symptoms and normal cognition or mild cognitive impairment and to study the further risk of developing dementia from any cause...
October 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28929433/development-and-feasibility-of-a-web-application-to-monitor-patients-cancer-related-pain
#10
Wendy H Oldenmenger, Mathilde A G Baan, Carin C D van der Rijt
BACKGROUND: In the outpatient setting, pain management is often inadequate in patients with cancer-related pain, because of patient- and professional-related barriers in communication and infrequent contacts. The internet may provide new opportunities for monitoring these patients. PURPOSE: The purpose of this study was to investigate whether internet monitoring of cancer-related pain in outpatients was feasible. METHODS: We developed an internet application that contained a pain diary, eConsult, and patient pain education...
September 19, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28929285/genomic-disorders-in-psychiatry-what-does-the-clinician-need-to-know
#11
REVIEW
Chelsea Lowther, Gregory Costain, Danielle A Baribeau, Anne S Bassett
PURPOSE OF REVIEW: The purpose of this review is to summarize the role of genomic disorders in various psychiatric conditions and to highlight important recent advances in the field that are of potential clinical relevance. RECENT FINDINGS: Genomic disorders are caused by large rare recurrent deletions and duplications at certain chromosomal "hotspots" (e.g., 22q11.2, 16p11.2, 15q11-q13, 1q21.1, 15q13.3) across the genome. Most overlap multiple genes, affect development, and are associated with variable cognitive and other neuropsychiatric expression...
September 20, 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28928938/the-elixir-excelerate-train-the-trainer-pilot-programme-empower-researchers-to-deliver-high-quality-training
#12
Sarah L Morgan, Patricia M Palagi, Pedro L Fernandes, Eija Koperlainen, Jure Dimec, Diana Marek, Lee Larcombe, Gabriella Rustici, Teresa K Attwood, Allegra Via
One of the main goals of the ELIXIR-EXCELERATE project from the European Union's Horizon 2020 programme is to support a pan-European training programme to increase bioinformatics capacity and competency across ELIXIR Nodes. To this end, a Train-the-Trainer (TtT) programme has been developed by the TtT subtask of EXCELERATE's Training Platform, to try to expose bioinformatics instructors to aspects of pedagogy and evidence-based learning principles, to help them better design, develop and deliver high-quality training in future...
2017: F1000Research
https://www.readbyqxmd.com/read/28928704/prediction-of-cognitive-decline-from-white-matter-hyperintensity-and-single-photon-emission-computed-tomography-in-alzheimer-s-disease
#13
Ken-Ichi Tabei, Hirotaka Kida, Tetsuo Hosoya, Masayuki Satoh, Hidekazu Tomimoto
BACKGROUND: While several studies support an association of white matter hyperintensity (WMH) volume and regional cerebral blood flow (rCBF) with cognitive decline in Alzheimer's disease (AD), no reports have simultaneously considered the effects of both factors on cognitive decline. OBJECTIVE: The purpose of the present study was to compare WMH volume and rCBF in relation to cognitive function by developing a new software program to fuse magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT) data...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28928681/how-does-l1-and-l2-exposure-impact-l1-performance-in-bilingual-children-evidence-from-polish-english-migrants-to-the-united-kingdom
#14
Ewa Haman, Zofia Wodniecka, Marta Marecka, Jakub Szewczyk, Marta Białecka-Pikul, Agnieszka Otwinowska, Karolina Mieszkowska, Magdalena Łuniewska, Joanna Kołak, Aneta Miękisz, Agnieszka Kacprzak, Natalia Banasik, Małgorzata Foryś-Nogala
Most studies on bilingual language development focus on children's second language (L2). Here, we investigated first language (L1) development of Polish-English early migrant bilinguals in four domains: vocabulary, grammar, phonological processing, and discourse. We first compared Polish language skills between bilinguals and their Polish non-migrant monolingual peers, and then investigated the influence of the cumulative exposure to L1 and L2 on bilinguals' performance. We then examined whether high exposure to L1 could possibly minimize the gap between monolinguals and bilinguals...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28928653/age-related-decline-in-anticipatory-motor-planning-and-its-relation-to-cognitive-and-motor-skill-proficiency
#15
Tino Stöckel, Kathrin Wunsch, Charmayne M L Hughes
Anticipatory motor planning abilities mature as children grow older, develop throughout childhood and are likely to be stable till the late sixties. In the seventh decade of life, motor planning performance dramatically declines, with anticipatory motor planning abilities falling to levels of those exhibited by children. At present, the processes enabling successful anticipatory motor planning in general, as do the cognitive processes mediating these age-related changes, remain elusive. Thus, the aim of the present study was (a) to identify cognitive and motor functions that are most affected by normal aging and (b) to elucidate key (cognitive and motor) factors that are critical for successful motor planning performance in young (n = 40, mean age = 23...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28928634/transcranial-alternating-current-stimulation-tacs-mechanisms-and-protocols
#16
REVIEW
Amir V Tavakoli, Kyongsik Yun
Perception, cognition and consciousness can be modulated as a function of oscillating neural activity, while ongoing neuronal dynamics are influenced by synaptic activity and membrane potential. Consequently, transcranial alternating current stimulation (tACS) may be used for neurological intervention. The advantageous features of tACS include the biphasic and sinusoidal tACS currents, the ability to entrain large neuronal populations, and subtle control over somatic effects. Through neuromodulation of phasic, neural activity, tACS is a powerful tool to investigate the neural correlates of cognition...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28928633/glutaminase-and-mmp-9-downregulation-in-cortex-and-hippocampus-of-lpa1-receptor-null-mice-correlate-with-altered-dendritic-spine-plasticity
#17
Ana Peñalver, José A Campos-Sandoval, Eduardo Blanco, Carolina Cardona, Laura Castilla, Mercedes Martín-Rufián, Guillermo Estivill-Torrús, Raquel Sánchez-Varo, Francisco J Alonso, Mercedes Pérez-Hernández, María I Colado, Antonia Gutiérrez, Fernando Rodríguez de Fonseca, Javier Márquez
Lysophosphatidic acid (LPA) is an extracellular lipid mediator that regulates nervous system development and functions acting through G protein-coupled receptors (GPCRs). Here we explore the crosstalk between LPA1 receptor and glutamatergic transmission by examining expression of glutaminase (GA) isoforms in different brain areas isolated from wild-type (WT) and KOLPA1 mice. Silencing of LPA1 receptor induced a severe down-regulation of Gls-encoded long glutaminase protein variant (KGA) (glutaminase gene encoding the kidney-type isoforms, GLS) protein expression in several brain regions, particularly in brain cortex and hippocampus...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28928348/cross-cultural-adaptation-of-jefferson-scale-of-empathy-health-professions-students-version-an-experience-with-developing-the-tamil-translation
#18
Kathiresan Jeyashree, Soundappan Kathirvel, Muthu K Prathibha
BACKGROUND: Empathy is a key cognitive attribute among healthcare professionals that fosters better patient- healthcare provider relationships. The Jefferson scale of empathy (JSE) measures self-rated empathy among various groups of healthcare professionals-health professionals, medical students and health professions students (HPS). The authors present the experience in translating the JSE-HPS version into an Indian regional language with insights into the issues faced in every step...
May 2017: Education for Health: Change in Training & Practice
https://www.readbyqxmd.com/read/28928299/a-study-on-knowledge-attitude-and-practice-regarding-mental-health-illnesses-in-amdanga-block-west-bengal
#19
Rivu Basu, Arkaprabha Sau, Soham Saha, Souren Mondal, Pradip Kumar Ghoshal, Sourav Kundu
BACKGROUND: The discourse of mental health is getting its due attention after all these years in India. A major threat to the mental health system is the demand side factors, namely, knowledge, attitude, and practice (KAP) of the general population toward this. In spite of growing concern regarding mental health in India, this kind of study to assess the mental health status has been very few in India, more so in West Bengal. OBJECTIVES: With this background, this study was carried out with the objectives to validate the Community Attitude to Mental Illness (CAMI), to assess the different sociodemographic factors among the study population, to assess the KAP regarding mental illness among the study population...
July 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28928195/reach-study-protocol-of-a-randomised-trial-of-rehabilitation-very-early-in-congenital-hemiplegia
#20
Roslyn N Boyd, Jenny Ziviani, Leanne Sakzewski, Iona Novak, Nadia Badawi, Kerstin Pannek, Catherine Elliott, Susan Greaves, Andrea Guzzetta, Koa Whittingham, Jane Valentine, Cathy Morgan, Margaret Wallen, Ann-Christin Eliasson, Lisa Findlay, Robert Ware, Simona Fiori, Stephen Rose
OBJECTIVES: Congenital hemiplegia is the most common form of cerebral palsy (CP). Children with unilateral CP show signs of upper limb asymmetry by 8 months corrected age (ca) but are frequently not referred to therapy until after 12 months ca. This study compares the efficacy of infant-friendly modified constraint-induced movement therapy (Baby mCIMT) to infant friendly bimanual therapy (Baby BIM) on upper limb, cognitive and neuroplasticity outcomes in a multisite randomised comparison trial...
September 18, 2017: BMJ Open
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