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https://www.readbyqxmd.com/read/28925594/pharyngoesophageal-diverticula-simulating-thyroid-nodules-an-unusual-occurrence-with-unique-features
#1
Karen K Nauschuetz, Lorna L Ogden, Cherry E Starling, Mohammad J Saleh, Allan C Golding, S Thomas Traweek
Pharyngoesophageal diverticula (PED) of the Zenker's and Killian-Jamieson types arise in close proximity to the thyroid gland, and may rarely be confused with a thyroid nodule on ultrasonography. In this brief report, we detail the cytologic, clinical, and radiologic findings of three PED that were thought to be thyroid nodules, and were subjected to fine-needle aspiration (FNA). The patients were females with an age range of 51-64 years. All three patients had multiple thyroid nodules, and two patients reported symptoms attributable to the diverticulum...
September 19, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28922378/relationships-of-orientation-discrimination-threshold-and-visual-acuity-with-macular-lesions-in-age-related-macular-degeneration
#2
Haojie Fu, Bin Zhang, Jianliang Tong, Harold Bedell, Hecheng Zhang, Yating Yang, Chaochao Nie, Yingdong Luo, Xiaoling Liu
PURPOSE: To measure visual acuity and metamorphopsia in patients with age-related macular degeneration (AMD) and to explore their relationship with macular lesions. METHODS: In this cross-sectional study, a total of 32 normal subjects (32 eyes) and 35 AMD patients (35 eyes) were recruited. They were categorized into 4 groups: normal, dry AMD, non-active wet AMD, and active wet AMD. Best-corrected visual acuity (BCVA) was measured using the Early Treatment Diabetic Retinopathy Study protocol...
2017: PloS One
https://www.readbyqxmd.com/read/28919342/mothers-adverse-childhood-experiences-and-their-young-children-s-development
#3
Jing Sun, Falguni Patel, Ruth Rose-Jacobs, Deborah A Frank, Maureen M Black, Mariana Chilton
INTRODUCTION: This study examined how mothers' Adverse Childhood Experiences (ACEs) relate to their children's developmental risk and assessed how the association is mediated through mothers' depressive symptoms and fair/poor health. METHODS: Mothers of children aged between 4 months and 4 years were recruited from the emergency department of a children's hospital between March 2012 and June 2015 and interviewed about ACEs, mothers' depressive symptoms and health status, and children's developmental risk (screened via Parents' Evaluations of Developmental Status [PEDS])...
September 14, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28915634/dna-methylation-signature-of-long-noncoding-rna-genes-during-human-pre-implantation-embryonic-development
#4
Jingyu Li, Wei Han, Xiaoli Shen, Shubiao Han, Hong Ye, Guoning Huang
DNA methylation have crucial roles in regulating the expression of developmental genes during mammalian pre-implantation embryonic development (PED). However, the DNA methylation dynamic pattern of long noncoding RNA (lncRNA) genes, one type of epigenetic regulators, in human PED have not yet been demonstrated. Here, we performed a comprehensive analysis of lncRNA genes in human PED based on public reduced representation bisulphite sequencing (RRBS) data. We observed that both lncRNA and protein-coding genes complete the major demethylation wave at the 2-cell stage, whereas the promoters of lncRNA genes show higher methylation level than protein-coding genes during PED...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28912285/predictors-of-incomplete-occlusion-following-pipeline-embolization-of-intracranial-aneurysms-is-it-less-effective-in-older-patients
#5
N Adeeb, J M Moore, M Wirtz, C J Griessenauer, P M Foreman, H Shallwani, R Gupta, A A Dmytriw, R Motiei-Langroudi, A Alturki, M R Harrigan, A H Siddiqui, E I Levy, A J Thomas, C S Ogilvy
BACKGROUND AND PURPOSE: Flow diversion with the Pipeline Embolization Device (PED) for the treatment of intracranial aneurysms is associated with a high rate of aneurysm occlusion. However, clinical and radiographic predictors of incomplete aneurysm occlusion are poorly defined. In this study, predictors of incomplete occlusion at last angiographic follow-up after PED treatment were assessed. MATERIALS AND METHODS: A retrospective analysis of consecutive aneurysms treated with the PED between 2009 and 2016, at 3 academic institutions in the United States, was performed...
September 14, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28906028/graft-outcomes-following-diagnosis-of-posttransplant-lymphoproliferative-disease-in-pediatric-kidney-recipients-a-retrospective-study
#6
Nele K Kanzelmeyer, Britta Maecker-Kolhoff, Henriette Zierhut, Christian Lerch, Murielle Verboom, Dieter Haffner, Lars Pape
Data related to graft outcomes following posttransplant lymphoproliferative disease (PTLD) in pediatric kidney transplantation are scarce. Data were analyzed retrospectively from 12 children (8 boys) for three years after diagnosis of PTLD, with a loss of follow-up after 2 years in 2/12. In all cases, intensity of immunosuppressive therapy was reduced, with switch from calcineurin inhibitor to a mammalian target of rapamcyin (mTOR) inhibitor in 6 cases. Nine children were treated with 6 doses of rituximab according to the PED-PTLD-2005 protocol, with additional treatment in one child as per protocol...
September 14, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28895632/-oct-angiography-in-exudative-amd-with-detachment-of-vascularised-retinal-pigment-epithelium
#7
Frederic Gunnemann, Kai Rothaus, Marie-Louise Farecki, Henrik Faatz, Benedikt Book, Albrecht Lommatzsch, Daniel Pauleikoff
Background The aim of the following extended case study was to analyse whether choroidal neovascularisation (CNV) in vascularised epithelial detachments (PED) in OCT angiography (OCT-A) can be better visualised in OCT-A than in the established angiographic methods during the course of anti-VEGF therapy and if possible used to quantify the CNV size and flow area. These findings were compared with other SD-OCT characteristics of the lesion (PED height, retinal thickness). Patients and Methods 8 patients with PED and associated CNV were diagnosed with multimodal imaging and additionally OCT angiography was performed...
September 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28892948/microperimetry-a-new-tool-for-assessing-retinal-sensitivity-in-macular-diseases
#8
Memota Laishram, Krishnagopal Srikanth, A R Rajalakshmi, Swathi Nagarajan, G Ezhumalai
INTRODUCTION: Macular disease is the leading cause of low vision in the Western world. Drusen and pigmentary irregularities are common among the rural Northern Indian population. The disease process leads to loss of central vision, metamorphopsia, macropsia or micropsia and colour vision defect. AIM: To study the retinal sensitivity changes in macular diseases using microperimetry. MATERIALS AND METHODS: It was an observational study, conducted in the Department of Ophthalmology at a rural tertiary care hospital...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28891028/the-use-of-optical-coherence-tomography-angiography-in-pachychoroid-spectrum-diseases-a-concurrent-comparison-with-dye-angiography
#9
Sibel Demirel, Özge Yanık, Hilal Nalcı, Figen Batıoğlu, Emin Özmert
PURPOSE: The study objective was to compare dye angiography and optical coherence tomography angiography (OCTA) in detecting choroidal neovascuarization (CNV) in patients presenting with pachychoroid features and flat irregular pigment epithelial detachment (PED). METHODS: Nineteen eyes of 17 patients, presenting with flat PED and pachychoroid features, and without age-related macular degeneration or any other degenerative change, were analyzed. Fuorescein angiography (FA)/Indocyanine green angiography (ICGA) and OCTA were performed during the same visit...
September 11, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28883628/virulence-of-current-german-pedv-strains-in-suckling-pigs-and-investigation-of-protective-effects-of-maternally-derived-antibodies
#10
S Leidenberger, Ch Schröder, L Zani, A Auste, M Pinette, A Ambagala, V Nikolin, H de Smit, M Beer, S Blome
Porcine epidemic diarrhea (PED) has caused tremendous losses to the United States pig industry since 2013. From 2014, outbreaks were also reported from Central Europe. To characterize the Central European PEDV strains regarding their virulence in suckling piglets, and to assess the protective effect of maternally derived antibodies (MDA), four trial groups were randomly assigned, each consisting of two pregnant sows and their litter. To induce MDA in a subset of piglets, two sows received a cell culture-adapted PEDV strain, and another two sows were inoculated with field material from German PED outbreaks...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28875350/enantioconvergent-hydrolysis-of-racemic-styrene-oxide-at-high-concentration-by-a-pair-of-novel-epoxide-hydrolases-into-r-phenyl-1-2-ethanediol
#11
Rui Wang, Die Hu, Xuncheng Zong, Jinping Li, Lei Ding, Minchen Wu, Jianfang Li
OBJECTIVES: To prepare (R)-phenyl-1,2-ethanediol ((R)-PED) with high enantiomeric excess (ee p) and yield from racemic styrene oxide (rac-SO) at high concentration by bi-enzymatic catalysis. RESULTS: The bi-enzymatic catalysis was designed for enantioconvergent hydrolysis of rac-SO by a pair of novel epoxide hydrolases (EHs), a Vigna radiata EH3 (VrEH3) and a variant (AuEH2(A250I)) of Aspergillus usamii EH2. The simultaneous addition mode of VrEH3 and AuEH2(A250I), exhibiting the highest average turnover frequency (aTOF) of 0...
September 5, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28872046/racial-and-ethnic-differences-in-antibiotic-use-for-viral-illness-in-emergency-departments
#12
Monika K Goyal, Tiffani J Johnson, James M Chamberlain, T Charles Casper, Timothy Simmons, Evaline A Alessandrini, Lalit Bajaj, Robert W Grundmeier, Jeffrey S Gerber, Scott A Lorch, Elizabeth R Alpern
BACKGROUND AND OBJECTIVES: In the primary care setting, there are racial and ethnic differences in antibiotic prescribing for acute respiratory tract infections (ARTIs). Viral ARTIs are commonly diagnosed in the pediatric emergency department (PED), in which racial and ethnic differences in antibiotic prescribing have not been previously reported. We sought to investigate whether patient race and ethnicity was associated with differences in antibiotic prescribing for viral ARTIs in the PED...
September 5, 2017: Pediatrics
https://www.readbyqxmd.com/read/28866409/intermolecular-vibrational-modes-and-h-bond-interactions-in-crystalline-urea-investigated-by-terahertz-spectroscopy-and-theoretical-calculation
#13
Yonghong Zhao, Zhi Li, Jianjun Liu, Cong Hu, Huo Zhang, Binyi Qin, Yifang Wu
The characteristic absorption spectra of crystalline urea in 0.6-1.8 THz region have been measured by terahertz time-domain spectroscopy at room temperature experimentally. Five broad absorption peaks were observed at 0.69, 1.08, 1.27, 1.47 and 1.64 THz respectively. Moreover, density functional theory (DFT) calculation has been performed for the isolated urea molecule, and there is no infrared intensity in the region below 1.8 THz. This means that single molecule calculations are failure to predict the experimental spectra of urea crystals...
August 25, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28866335/predictors-of-outcomes-and-refractoriness-in-status-epilepticus-a-prospective-study
#14
Murat Mert Atmaca, Nerses Bebek, Betül Baykan, Ayşen Gökyiğit, Candan Gürses
OBJECTIVE: The objective of this study was to determine the predictors of outcomes and refractoriness in status epilepticus (SE). METHODS: This is a prospective study of 59 adult patients with SE who were admitted to the Emergency Department between February 2012 and December 2013. The effects of clinical, demographic, and electrophysiologic features of patients with SE were evaluated. To evaluate outcome in SE, STESS, mSTESS, and EMSE scales were used. RESULTS: Logistic regression analysis showed that being aged ≥65years (p=0...
August 31, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28863286/flow-diversion-with-the-pipeline-embolization-device-for-patients-with-intracranial-aneurysms-and-antiplatelet-therapy-a-systematic-literature-review
#15
REVIEW
Pavlos Texakalidis, Kimon Bekelis, Elias Atallah, Stavropoula Tjoumakaris, Robert H Rosenwasser, Pascal Jabbour
Flow diversion with the Pipeline Embolization Device (PED) is reported as a safe and efficient treatment for patients with intracranial aneurysms; however, literature discussing the antiplatelet (APT) regimen used before and after the PED is limited. Our aim was to systematically review and summarize available data regarding the APT regimen and the platelet function test (PFT) that was used. We also sought to provide an overview of the aneurysm morphologies and adverse event rates associated with the PED use...
August 18, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28862426/digitally-controlled-procedure-for-assembling-fully-drawn-paper-based-electroanalytical-platforms
#16
Nicolò Dossi, Stefano Petrazzi, Rosanna Toniolo, Franco Tubaro, Fabio Terzi, Evandro Piccin, Rossella Svigelj, Gino Bontempelli
A simple, reliable, and low-cost fabrication method is proposed here for assembling paper-based electrochemical devices (PEDs) using a commercial desktop digitally controlled plotter/cutter, together with ordinary writing tools. Permanent markers (tips of 1 mm) were used to create effective hydrophobic barriers on paper, while micromechanical pencils (mounting 4B graphite leads, 0.5 mm in diameter) were adopted for automatically drawn precise reference, counter, and working carbon electrodes. Fabrication parameters, such as writing pressure and speed, were first optimized, and the electrochemical performance of these devices was then evaluated by using potassium hexacyanoferrate(II) as redox probe...
September 13, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28858042/yield-of-anaerobic-blood-cultures-in-pediatric-emergency-department-patients
#17
Itai Gross, Oren Gordon, Wiessam Abu Ahmad, Shmuel Benenson, Ben Simon Piatkowski, Smadar Eventov-Friedman, Saar Hashavya
BACKGROUND AND OBJECTIVES: Anaerobic bacteremia is rare in children and current recommendations advocate against the routine use of anaerobic cultures in children. However, the incidence of anaerobic bacteremia and the utility of anaerobic blood cultures in children have not been assessed in recent years. Our pediatric emergency department (PED) policy still supports the use of both aerobic and anaerobic blood cultures in all cases of suspected bacteremia. This allowed us to re-evaluate the yield of anaerobic cultures in PED settings...
August 26, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28846977/structural-and-vibrational-study-of-a-neurotransmitter-molecule-dopamine-4-2-aminoethyl-benzene-1-2-diol
#18
Omkant Jha, T K Yadav, R A Yadav
Structural and vibrational studies for the most stable conformer of dopamine {4-(2-Aminoethyl) benzene-1, 2-diol} have been carried out at the DFT/B3LYP/6-311++G** level using the Gaussian 09 software. The IR and Raman spectra have been recorded and analyzed in light of the computed vibrational parameters using the DFT and the PEDs computed with the help of the GAR2PED software. Some of the fundamentals have considerably changed frequencies in going from benzene to dopamine. Except the rocking and wagging modes of the NH2 group the other four modes are pure group modes...
August 2, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28844913/analysis-of-predictors-and-probability-of-aneurysm-occlusion-in-the-ica-after-treatment-with-pipeline-embolization-device
#19
Leonardo B C Brasiliense, Pedro Aguilar-Salinas, David A Miller, Rabih G Tawk, Eric A Sauvageau, Ricardo A Hanel
BACKGROUND: Although the PED has proven to be an excellent option for ICA aneurysms, the rate of occlusion remains difficult to predict and factors associated with aneurysm occlusion are not well elucidated. This study aimed to investigate predictors and the rate of occlusion for aneurysms along the ICA. METHODS: 117 saccular ICA aneurysms treated with the PED were studied. Occlusion rates were divided among 4 groups. Group A [lesions > 10 mm in the proximal ICA (petrous to the superior hypophyseal segments)]...
August 24, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28843485/a-novel-transfer-of-care-sign-out-assessment-tool-in-a-pediatric-emergency-department
#20
Ara Festekjian, Ameer P Mody, Todd P Chang, Nurit Ziv, Alan L Nager
OBJECTIVE: Transfer of care sign-outs (TOCS) for admissions from a Pediatric Emergency Department (PED) have unique challenges. Standardized and reliable assessment tools for TOCS remain elusive. We describe the development, reliability, and validity of a TOCS assessment tool. METHODS: Video recordings of resident TOCS were assessed to capture four domains: completeness, synopsis, foresight, and professionalism. In phase one, 56 TOCS were used to modify the tool and improve reliability...
August 23, 2017: Academic Pediatrics
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