Matthew Dankner, Sarah M Maritan, Neibla Priego, Georgia Kruck, Andriniaina Nkili-Meyong, Javad Nadaf, Rebecca Zhuang, Matthew G Annis, Dongmei Zuo, Alexander Nowakowski, Marco Biondini, Alexander Kiepas, Caitlyn Mourcos, Phuong Le, Francois Charron, Yanis Inglebert, Paul Savage, Louis Théret, Marie-Christine Guiot, R Anne McKinney, William J Muller, Morag Park, Manuel Valiente, Kevin Petrecca, Peter M Siegel
BACKGROUND: Compared to minimally invasive brain metastases (MI BrM), highly invasive (HI) lesions form abundant contacts with cells in the peritumoral brain parenchyma and are associated with poor prognosis. Reactive astrocytes (RAs) labeled by phosphorylated STAT3 (pSTAT3) have recently emerged as a promising therapeutic target for BrM. Here, we explore whether BrM invasion pattern is influenced by pSTAT3+ RAs and may serve as a predictive biomarker for STAT3 inhibition. METHODS: We used immunohistochemistry to identify pSTAT3+ RAs in HI and MI human and patient-derived xenograft (PDX) BrM...
January 25, 2024: Neuro-oncology