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https://www.readbyqxmd.com/read/27910776/molecular-pathology-of-malignant-transformation-of-oral-submucous-fibrosis
#1
Amit Chattopadhyay, Jay Gopal Ray
Oral submucous fibrosis (OSF) is prevalent mostly in Southeast Asia, particularly in the Indian subcontinent. Chewing betel nuts and betel leaves, with or without tobacco, has been associated with OSF. Betel quid contents including guvacine, arecoline, guvacoline, arecaidine, and chavibetol are considered to play an important part in the occurrence of OSF. Transformation of OSF to squamous cell carcinoma (SCC) is variable, but up to 13% conversion of OSF to SCC has been reported. Various genetic and molecular mechanisms impact the malignant transformation of OSF, causing changes in the cell cycle, DNA, keratinocytes, and keratin; tumor-cell proliferation and survival; angiogenesis; fibrosis through epithelial-mesenchymal transitions (EMTs), and tissue hypoxia...
2016: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/27869455/an-interference-model-of-visual-working-memory
#2
Klaus Oberauer, Hsuan-Yu Lin
The article introduces an interference model of working memory for information in a continuous similarity space, such as the features of visual objects. The model incorporates the following assumptions: (a) Probability of retrieval is determined by the relative activation of each retrieval candidate at the time of retrieval; (b) activation comes from 3 sources in memory: cue-based retrieval using context cues, context-independent memory for relevant contents, and noise; (c) 1 memory object and its context can be held in the focus of attention, where it is represented with higher precision, and partly shielded against interference...
November 21, 2016: Psychological Review
https://www.readbyqxmd.com/read/27851781/characterization-of-a-novel-dermal-fibrosis-model-induced-by-areca-nut-extract-that-mimics-oral-submucous-fibrosis
#3
Min-Hsuan Chiang, Ping-Ho Chen, Yuk-Kwan Chen, Chia-Hsin Chen, Mei-Ling Ho, Yan-Hsiung Wang
Oral submucous fibrosis (OSF) is an oral potentially malignant disorder and areca quid chewing is the main etiological factor. However, the molecular mechanism underlying OSF remains unclear, partly due to the lack of an appropriate animal model. The present study aimed to establish and characterize an animal model of areca nut extract (ANE)-induced skin fibrosis that mimics OSF. Mice were divided into 4 groups: the control group; the bleomycin group; and the ANE10 and ANE20 groups, which received 10mg/ml and 20mg/ml subcutaneous (SC) injection of ANE, respectively...
2016: PloS One
https://www.readbyqxmd.com/read/27845370/aberrant-ssea-4-upregulation-mediates-myofibroblast-activity-to-promote-pre-cancerous-oral-submucous-fibrosis
#4
Cheng-Chia Yu, Chuan-Hang Yu, Yu-Chao Chang
Oral submucous fibrosis (OSF), regarded as a precancerous condition, is characterized by juxta-epithelial inflammatory reaction followed by fibro-elastic change in the lamina properia and epithelial atrophy. The pathologic mechanisms of OSF still need to be further clarified. In the study, we investigated the functional expression of SSEA-4, which is a well-known stemness marker, in myofibroblast activity and the clinical significance in OSF tissues. The expression of SSEA-4 in OSF was evaluated by immunohistochemical staining...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27779604/the-prediction-and-prevention-of-dysphagia-after-occipitospinal-fusion-by-use-of-the-s-line-swallowing-line
#5
Shuichi Kaneyama, Masatoshi Sumi, Masato Takabatake, Koichi Kasahara, Aritetsu Kanemura, Hiroaki Hirata, Bruce V Darden
STUDY DESIGN: Clinical case series and risk factor analysis of dysphagia after occipitospinal fusion (OSF). OBJECTIVE: To develop new criteria to avoid postoperative dysphagia by analyzing the relationship among the craniocervical alignment, the oropharyngeal space and the incidence of dysphagia after OSF. SUMMARY OF BACKGROUND DATA: Craniocervical malalignment after OSF is considered to be one of the primary triggers of postoperative dysphagia...
October 24, 2016: Spine
https://www.readbyqxmd.com/read/27777969/a-study-to-analyze-different-patterns-of-quid-usage-among-subjects-with-oral-submucous-fibrosis-in-mangalore-population
#6
Vidya A Holla, L K Chatra, Prashanth Shenai, Devika Shetty, Ashwini Baliga
Aim and Objectives. Oral submucous fibrosis (OSF) is a potentially malignant disorder associated with the usage of areca nut. Usage of processed forms of areca nut is popular among the youth and its carcinogenic effects are not well known. Due to large immigrant population, various patterns of areca nut usage are seen. The aim of this study is to assess the various quid chewing patterns and their association with severity of OSF. Materials and Methods. A cross-sectional study was carried out with 250 cases clinically and histologically diagnosed as having OSF lesion that were selected and subjected to a detailed habit history which was recorded through preformed questionnaire...
2016: Advances in Medicine
https://www.readbyqxmd.com/read/27769912/expression-of-fibrosis-related-molecules-in-the-oral-mucosa-of-six-animal-species-a-reference-for-selecting-animal-models
#7
Guoliang Sa, Xuepeng Xiong, Jiangang Ren, Yifang Zhao, Sangang He
Several animal models have been used in studies associated with oral submucous fibrosis (OSF); however, an appropriate model based on the histopathological characteristics of OSF is still needed. This study aimed to provide histological references for selecting a potential model. The expression intensities of collagen type I (Col I), type III (Col III), type IV (Col IV), fibronectin (FN), transforming growth factors β (TGF-β), and connective tissue growth factor (CCN2) in the oral mucosa of the human and six non-human animal species were measured by immunohistochemistry...
October 18, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27750161/nanomechanical-signatures-of-oral-submucous-fibrosis-in-sub-epithelial-connective-tissue
#8
Anji Anura, Debanjan Das, Mousumi Pal, Ranjan Rashmi Paul, Soumen Das, Jyotirmoy Chatterjee
Oral sub-mucous fibrosis (OSF), a potentially malignant disorder, exhibits extensive remodeling of extra-cellular matrix in the form of sub-epithelial fibrosis which is a possible sequel of assaults from different oral habit related irritants. It has been assumed that micro/nanobio-mechanical imbalance experienced in the oral mucosa due to fibrosis may be deterministic for malignant potential (7-13%) of this pathosis. Present study explores changes in mechanobiological attributes of sub-epithelial connective tissue of OSF and the normal counterpart...
September 20, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27743497/limited-mouth-opening-in-oral-submucous-fibrosis-reasons-ramifications-and-remedies
#9
Mohit Sharma, Raghu Radhakrishnan
Limited mouth opening (LMO) in Oral Submucous Fibrosis (OSF) has been attributed to both the submucosal and muscle fibrosis (MF). While, reflectory trismus was proposed before as an auxiliary mechanism by another group; the stretch mediated muscle damage (MSD), histopathological changes in blood vessels (like endothelial dysfunction, endothelial hypertrophy and endarteritis obliterans) and upregulated anaerobic isoforms of lactate dehydrogenase (LDH), have been proposed by us as complementary events leading to MF...
October 15, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27739057/increased-chondrogenic-potential-of-mesenchymal-cells-from-adipose-tissue-versus-bone-marrow-derived-cells-in-osteoarthritic-in-vitro-models
#10
Stefania Pagani, Veronica Borsari, Francesca Veronesi, Andrea Ferrari, Simona Cepollaro, Paola Torricelli, Giuseppe Filardo, Milena Fini
OBJECTIVES: Primarily, to compare the behavior of human mesenchymal stem cells (MSCs) derived from bone marrow (hBMSCs) and adipose tissue (hADSCs) in an osteoarthritic (OA) microenvironment; secondly, to investigate the reaction of these cell types in two alternative in vitro culture systems, obtained by using TNFα and/or IL1β as inflammation mediators, or by using synovial fluid harvested by OA patients (OSF) to simulate the complex inflamed knee microenvironment. METHODS: 3D micromass cultures of hBMSCs or hADSCs were grown in chondrogenic medium (CTR), in the presence of TNFα and/or IL1β, or synovial fluid from OA patients...
October 14, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27722225/implants-inserted-with-graftless-osteotome-sinus-floor-elevation-a-5-year-post-loading-retrospective-study
#11
Alexander Zill, Clarissa Precht, Benedicta Beck-Broichsitter, Susanne Sehner, Ralf Smeets, Max Heiland, Carsten Rendenbach, Anders Henningsen
PURPOSE: To report the outcome of graftless osteotome sinus floor elevation (OSFE) in order to evaluate whether apical bone gain depends on the initial residual bone height and whether the initial residual bone height has an influence on the amount of marginal bone loss. Furthermore the study aimed to assess if perforations of the Schneiderian membrane or residual bone height are potential predictors of implant survival. MATERIALS AND METHODS: In this retrospective study all patients were included who were treated between 2001 and 2010 and received dental implants in combination with OSFE in a private practice...
2016: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/27719707/-expression-of-secreted-frizzled-related-protein-1-in-patient-with-oral-submucous-fibrosis
#12
F Y Lyu, H F Wang, C J Xu, Z Xu, D M Li, Y T Chi
Objective: To investigate the concentrations and clinical significance of secreted frizzled-related protein-1(SFRP1) insaliva and gingival crevicular fluid of patients with oral submucous fibrosis (OSF) as well as the expression of SFRP1 in patients' OSF buccal mucosa. Methods: Twenty OSF patients aged 20 to 40 years old were recruited and randomly divided into two experimental groups, of which were triamcinolone acetonide group and combined triamcinolone acetonide and salvia miltiorrhiza group, respectively...
October 9, 2016: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/27716298/collaborative-assessment-and-management-of-suicidality-cams-compared-to-treatment-as-usual-tau-for-suicidal-patients-study-protocol-for-a-randomized-controlled-trial
#13
Wenche Ryberg, Roar Fosse, Per Henrik Zahl, Inge Brorson, Paul Møller, Nils Inge Landrø, David Jobes
BACKGROUND: Collaborative Assessment and Management of Suicidality (CAMS) is a therapeutic framework that appears promising to reduce suicidal ideation and suicidal cognition. CAMS has not previously been evaluated in a standard specialized mental health care setting for patients with suicidal problems in general. In this pragmatic randomized controlled trial (RCT) we will investigate if CAMS is more effective than treatment as usual (TAU) in reducing suicidal thoughts and behaviors. Effects will also be investigated on mental health and symptom relief in general and upon readmissions to inpatient units...
October 3, 2016: Trials
https://www.readbyqxmd.com/read/27708346/role-of-areca-nut-induced-jnk-atf2-jun-axis-in-the-activation-of-tgf-%C3%AE-pathway-in-precancerous-oral-submucous-fibrosis
#14
Ila Pant, S Girish Rao, Paturu Kondaiah
Oral submucous fibrosis (OSF) is potentially premalignant with progressive and irreversible extracellular matrix deposition accompanied by epithelial atrophy and like other fibrotic disorders, is primarily a TGF-β driven disease. OSF is caused by prolonged chewing of areca nut. Our previous studies reported a pivotal role for TGF-β activation and its effects contributing to OSF. However, the mechanism for activation of TGF-β signaling in OSF is still unknown. In this study we demonstrate activation of TGF-β signaling with sub-cytotoxic dose of areca nut in epithelial cells and discovered a key role for pJNK in this process...
October 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27642309/in-vitro-characterization-and-oral-bioavailability-of-organic-solvent-free-solid-dispersions-containing-telmisartan
#15
Yue Cao, Li-Li Shi, Qing-Ri Cao, Mingshi Yang, Jing-Hao Cui
Poorly water-soluble drugs often suffer from limited or irreproducible clinical response due to their low solubility and dissolution rate. In this study, organic solvent-free solid dispersions (OSF-SDs) containing telmisartan (TEL) were prepared using polyvinylpyrrolidone K30 (PVP K30) and polyethylene glycol 6000 (PEG 6000) as hydrophilic polymers, sodium hydroxide (NaOH) as an alkalizer, and poloxamer 188 as a surfactant by a lyophilization method. In-vitro dissolution rate and physicochemical properties of the OSF-SDs were characterized using the USP I basket method, differential scanning calorimetry (DSC), X-ray diffractometry (XRD) and fourier transform-infrared (FT-IR) spectroscopy...
2016: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/27628043/idgenerator-unique-identifier-generator-for-epidemiologic-or-clinical-studies
#16
Matthias Olden, Rolf Holle, Iris M Heid, Klaus Stark
BACKGROUND: Creating study identifiers and assigning them to study participants is an important feature in epidemiologic studies, ensuring the consistency and privacy of the study data. The numbering system for identifiers needs to be random within certain number constraints, to carry extensions coding for organizational information, or to contain multiple layers of numbers per participant to diversify data access. Available software can generate globally-unique identifiers, but identifier-creating tools meeting the special needs of epidemiological studies are lacking...
2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27624188/association-between-electronic-cigarette-use-and-changes-in-quit-attempts-success-of-quit-attempts-use-of-smoking-cessation-pharmacotherapy-and-use-of-stop-smoking-services-in-england-time-series-analysis-of-population-trends
#17
Emma Beard, Robert West, Susan Michie, Jamie Brown
OBJECTIVES:  To estimate how far changes in the prevalence of electronic cigarette (e-cigarette) use in England have been associated with changes in quit success, quit attempts, and use of licensed medication and behavioural support in quit attempts. DESIGN:  Time series analysis of population trends. PARTICIPANTS:  Participants came from the Smoking Toolkit Study, which involves repeated, cross sectional household surveys of individuals aged 16 years and older in England...
2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27601808/dental-informatics-tool-sofpro-for-the-study-of-oral-submucous-fibrosis
#18
Dinesh Masajirao Erlewad, Kalpana Anandrao Mundhe, Vinay K Hazarey
BACKGROUND: Dental informatics is an evolving branch widely used in dental education and practice. Numerous applications that support clinical care, education and research have been developed. However, very few such applications are developed and utilized in the epidemiological studies of oral submucous fibrosis (OSF) which is affecting a significant population of Asian countries. AIMS AND OBJECTIVES: To design and develop an user friendly software for the descriptive epidemiological study of OSF...
May 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27596341/-target-regulation-of-micro-rna-203-to-the-expression-of-collagen-type-%C3%A2-alpha-4-and-its-role-in-oral-submucous-fibrosis
#19
J Chen, B J Liu, C Du, Q Cao, M Li, H Feng
OBJECTIVE: To explore the effect of microRNA-203(miR-203) on the expression of collagen type IV alpha 4(COL4A4) and its role in oral submucous fibrosis(OSF). METHODS: It has been revealed that COL4A4 is the putative target of miR-203 by retrieving a variety of bioinformatics software tools. The expression of COL4A4 protein in the indicated tissues was examined by Western blotting analysis and the potential binding sites of miR-203 and COL4A4-3'UTR was analyzed by using bioinformatics...
September 2016: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/27573908/reassessment-of-patients-with-eating-disorders-after-moving-from-dsm-iv-towards-dsm-5-a-retrospective-study-in-a-clinical-sample
#20
Malvina Gualandi, Marzia Simoni, Emilia Manzato, Giovanni Scanelli
PURPOSE: To compare the relative prevalence of eating disorders moving from DSM-IV to DSM-5, and to reassess the overall medical impairment in the revised diagnostic classes. METHODS: We applied DSM-5 to 206 patients (age 15-56 years) previously studied and classified according to DSM-IV. Medical impairment was classified as low, medium, or high, based on a cumulative score of clinical severity (SCS), computed as the sum of specific weights assigned to different pathological conditions and their ascertained prognostic impact...
August 29, 2016: Eating and Weight Disorders: EWD
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