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https://www.readbyqxmd.com/read/29134543/bayesian-inference-for-psychology-part-iii-parameter-estimation-in-nonstandard-models
#1
Dora Matzke, Udo Boehm, Joachim Vandekerckhove
We demonstrate the use of three popular Bayesian software packages that enable researchers to estimate parameters in a broad class of models that are commonly used in psychological research. We focus on WinBUGS, JAGS, and Stan, and show how they can be interfaced from R and MATLAB. We illustrate the use of the packages through two fully worked examples; the examples involve a simple univariate linear regression and fitting a multinomial processing tree model to data from a classic false-memory experiment. We conclude with a comparison of the strengths and weaknesses of the packages...
November 13, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29131522/when-do-two-stage-processes-outperform-one-stage-processes
#2
Steffen Klamt, Radhakrishnan Mahadevan, Oliver Hädicke
Apart from product yield and titer, volumetric productivity is a key performance indicator for many biotechnological processes. Due to the inherent trade-off between the production of biomass as catalyst and of the actual target product, yield and volumetric productivity cannot be optimized simultaneously. Therefore, in combination with genetic techniques for dynamic regulation of metabolic fluxes, two-stage fermentations (TSFs) with separated growth and production phase have recently gained much interest because of their potential to improve the productivity of bioprocesses while still allowing high product yields...
November 13, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/29119715/glabridin-inhibits-the-activation-of-myofibroblasts-in-human-fibrotic-buccal-mucosal-fibroblasts-through-tgf-%C3%AE-smad-signaling
#3
Ping-Hui Lee, Pei-Ming Chu, Pei-Ling Hsieh, Hui-Wen Yang, Pin Ju Chueh, Yu-Feng Huang, Yi-Wen Liao, Cheng-Chia Yu
Oral submucous fibrosis (OSF) has been recognized as one of the oral potentially malignant disorders. Areca nut chewing is implicated in this pathological fibrosis, and it causes chronic inflammation and persistent activation of myofibroblasts. As yet, existing treatments only provide temporary symptomatic relief and there is a lack of an effective intervention to cure OSF. Therefore, development of approaches to ameliorate myofibroblast activities becomes a crucial objective to prevent the malignant progression of OSF...
November 9, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28986385/the-role-of-halofuginone-in-fibrosis-more-to-be-explored
#4
REVIEW
Yin Luo, Xiaoyan Xie, Di Luo, Yuan Wang, Yijun Gao
Fibrosis, which can be defined as an abnormal or excessive accumulation of extracellular matrix (ECM), particularly fibrillar collagens, is a key driver of progressive organ dysfunction in many inflammatory and metabolic diseases, including idiopathic pulmonary fibrosis (IPF), cirrhosis, nephropathy, and oral submucous fibrosis (OSF). It has been estimated to contribute to ∼45% of deaths in the developed world. Therefore, agents that target specific fibrotic pathways, with the consequence of slowing, arresting, or even reversing the progression of tissue fibrogenesis, are urgently needed...
October 6, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28984080/inhibitory-effect-of-gmi-an-immunomodulatory-protein-from-ganoderma-microsporum-on-myofibroblast-activity-and-proinflammatory-cytokines-in-human-fibrotic-buccal-mucosal-fibroblasts
#5
Ping-Hui Lee, Pei-Ling Hsieh, Yi-Wen Liao, Cheng-Chia Yu
Oral submucous fibrosis (OSF) has been indicated as one of the oral potentially malignant disorders. Epidemiological studies have attributed this pathological fibrosis to the habit of areca nuts chewing, which causes chronic inflammation and persistent activation of myofibroblasts in the oral cavity. Hence, it is crucial to find an effective intervention to ameliorate inflammation in order to prevent the malignant progression of OSF. In this study, we assessed the anti-inflammatory effect of the immunomodulatory protein, GMI, extracted from Ganoderma microsporum on the expression proinflammatory cytokines and the myofibroblast characteristics in human fibrotic buccal mucosal fibroblasts (fBMFs)...
October 6, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28977942/periostin-promotes-epithelial-mesenchymal-transition-via-the-mapk-mir-381-axis-in-lung-cancer
#6
Wei-Wei Hu, Po-Chun Chen, Jun-Ming Chen, Yue-Ming Wu, Po-Yi Liu, Chih-Hao Lu, Yu-Feng Lin, Chih-Hsin Tang, Chia-Chia Chao
Periostin (POSTN, PN, or osteoblast-specific factor OSF-2) is a multifunctional cytokine that signals between the cell and the extracellular matrix. Periostin plays an important role in tumor development and is involved in carcinoma cell epithelial-mesenchymal transition (EMT), whereby mature epithelial cells undergo phenotypic morphological changes and become invasive, motile cells. Here, we discuss the molecular mechanisms involved in periostin-induced promotion of EMT in lung cancer cells. Online TCGA datasets demonstrate the prognostic relevance of periostin in lung cancer; a higher periostin level correlates with poor overall survival...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28971118/data-on-eye-behavior-during-idea-generation-and-letter-by-letter-reading
#7
Sonja Walcher, Christof Körner, Mathias Benedek
This article includes the description of data information from an idea generation task (alternate uses task, (Guilford, 1967) [1]) and a letter-by-letter reading task under two background brightness conditions with healthy adults as well as a baseline measurement and questionnaire data (SIPI (Huba et al., 1981) [2]; DDFS (Singer and Antrobus, 1972) [3], 1963; RIBS (Runco et al., 2001) [4]). Data are hosted at the Open Science Framework (OSF): https://osf.io/fh66g/ (Walcher et al., 2017) [5]. There you will find eye tracking data, task performance data, questionnaires data, analyses scripts (in R, R Core Team, 2017 [6]), eye tracking paradigms (in the Experiment Builder (SR Research Ltd...
December 2017: Data in Brief
https://www.readbyqxmd.com/read/28963857/prevalence-and-severity-of-eating-disorders-a-comparison-of-dsm-iv-and-dsm-5-among-german-adolescents
#8
Verena Ernst, Arne Bürger, Florian Hammerle
OBJECTIVE: Changes in the DSM-5 eating disorders criteria sought to increase the clarity of the diagnostic categories and to decrease the preponderance of nonspecified eating disorders. The first objective of this study was to analyze how these revisions affect threshold and EDNOS/OSFED eating disorder diagnoses in terms of prevalence, sex ratios, and diagnostic distribution in a student sample. Second, we aimed to compare the impairment levels of participants with a threshold, an EDNOS/OSFED and no diagnosis using both DSM-IV and DSM-5...
September 30, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28877246/prosthetic-rehabilitation-of-oral-submucous-fibrosis-patients-a-systematic-review-of-published-case-reports-and-case-series
#9
REVIEW
Shankargouda Patil, Sachin Chakradhar Sarode, Gargi S Sarode, Shilpa Bhandi, Kamran Habib Awan, Marco Ferrari
BACKGROUND: Oral submucous fibrosis (OSF) is an insidious chronic condition characterized by restricted mouth opening. Prosthetic rehabilitation is challenging for OSF patients as obtaining a good impression requires adequate mouth opening. The aim of the present review is to systematically present the data from case reports published in the English-language literature. METHOD: A comprehensive search of the literature databases (PubMed, Medline, SCOPUS, Web of Science and Google Scholar) along with the references of published articles on prosthetic rehabilitation in OSF patients published to date was conducted...
2017: PloS One
https://www.readbyqxmd.com/read/28861457/data-and-material-of-the-safe-range-inventory-an-assistance-tool-helping-to-improve-the-charging-infrastructure-for-electric-vehicles
#10
Claus-Christian Carbon, Fabian Gebauer
The Safe-Range-Inventory (SRI) was constructed in order to help public authorities to improve the charging infrastructures for electric vehicles [1; 10.1016/j.trf.2017.04.011]. Specifically, the impact of fast (vs slow) charging stations on people's range anxiety was examined. Ninety-seven electric vehicle users from Germany (81 male; Mage=46.3 years, SD=12.1) were recruited to participate in the experimental design. Statistical analyses were conducted using ANOVA for repeated measures to test for interaction effects of available charging stations and remaining range with the dependent variable range anxiety...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28855201/intersectoral-approaches-and-integrated-services-in-achieving-the-right-to-health-for-refugees-upon-resettlement-a-scoping-review-protocol
#11
Dena Javadi, Etienne V Langlois, Shirley Ho, Peter Friberg, Göran Tomson
INTRODUCTION: Global insecurity and climate change are exacerbating the need for improved management of refugee resettlement services. International standards hold states responsible for the protection of the right of non-citizens to an adequate standard of physical and mental health while recognising the importance of social determinants of health. However, programmes to protect refugees' right to health often lack coordination and monitoring. This paper describes the protocol for a scoping review to explore barriers and facilitators to the integration of health services for refugees; the content, process and actors involved in protecting refugee health; and the extent to which intersectoral approaches are leveraged to protect refugees' right to health on resettlement, especially for vulnerable groups such as women and children...
August 30, 2017: BMJ Open
https://www.readbyqxmd.com/read/28853214/long-term-evaluation-of-osteotome-sinus-floor-elevation-and-simultaneous-placement-of-implants-without-bone-grafts-10-year-radiographic-and-clinical-follow-up
#12
Janusz Caban, Robert Fermergård, Jahan Abtahi
BACKGROUND: Insertion of an implant in the edentulous posterior maxilla is a challenging procedure because of poor bone quality and increased pneumatization of the maxillary sinus after tooth extraction. To increase the amount of bone, several surgical bone grafting techniques have been used-with considerable morbidity for patients. Osteotome sinus floor elevation (OSFE) is a less invasive technique. The clinical and radiographic outcome of 53 implants placed with this technique without bone graft has been reported previously...
August 29, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28821582/identification-of-%C3%AE-enolase-as-a-prognostic-and-diagnostic-precancer-biomarker-in-oral-submucous-fibrosis
#13
Swarnendu Bag, Debabrata Dutta, Amrita Chaudhary, Bidhan Chandra Sing, Mousumi Pal, Ajoy Kumar Ray, Rita Banerjee, Ranjan Rashmi Paul, Amit Basak, Amit Kumar Das, Jyotirmoy Chatterjee
AIMS: Diagnostic ambiguities regarding the malignant potentiality of oral submucous fibrosis (OSF), an oral precancerous condition having dysplastic and non-dysplastic isoforms are the major failure for early intervention of oral squamous cell carcinoma (OSCC) patients. Our goal is to identify proteomic signatures from biopsies that can be used as precancer diagnostic marker for patient suffering from OSF. METHODS: The high throughput techniques adopting de novo peptide sequencing (1D SDS-PAGE coupled nanoLC MALDI tandem mass spectrometry (MS/MS)-based peptide mass fingerprint), immunohistochemistry (IHC), Western blot (WB) and real-time PCR (RT-PCR) analysis are considered for such biomarker identification and multilevel validations...
August 18, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28816025/aromatic-interactions-at-the-ligand-protein-interface-implications-for-the-development-of-docking-scoring-functions
#14
Michal Brylinski
The ability to design and fine-tune non-covalent interactions between organic ligands and proteins is indispensable to rational drug development. Aromatic stacking has long been recognized as one of the key constituents of ligand-protein interfaces. In this communication, we employ a two-parameter geometric model to conduct a large-scale statistical analysis of aromatic contacts in the experimental and computer-generated structures of ligand-protein complexes, considering various combinations of aromatic amino acid residues and ligand rings...
August 17, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28815252/-expression-of-ptprz1-in-oral-squamous-cell-carcinoma-originated-from-oral-submucous-fibrosis-and-its-clinical-significance
#15
Rong Zhu, Xin-Chun Jian, De-Yu Liu, Chao Zhou, Yuan Wang
PURPOSE: This study was aimed to detect the expression of PTPRZ1 in oral squamous cell carcinoma (OSCC) originated from oral submucous fibrosis (OSF), and discuss its role in the development and progression of OSCC originating from OSF as well as its clinical significance. METHODS: Immunohistochemisty (IHC) and Western blot (WB) for the expression and distribution of PTPRZ1 were carried out in 36 cases of OSF transforming into OSCC, 23 cases of OSCC and 21 cases of healthy controls...
April 2017: Shanghai Kou Qiang Yi Xue, Shanghai Journal of Stomatology
https://www.readbyqxmd.com/read/28803085/palliative-care-in-south-africa
#16
Cornelia Drenth, Zodwa Sithole, Esme Pudule, Sheryl Wüst, Nicola GunnClark, Liz Gwyther
The Hospice Palliative Care Association (HPCA) was established in 1987 by hospices in South Africa who felt the need for a national body to share best practices and to promote palliative care services in South Africa. HPCA supports member hospices in providing palliative care to people of any age with a life-limiting condition. HPCA has the further aim to ensure access to palliative care in settings other than member hospices. Many projects were launched over the years to influence policy, and to educate medical practitioners, nurses, social workers, theologians, and community caregiver; and to develop services...
August 9, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28797860/palliative-care-for-tuberculosis
#17
Stephen R Connor
In 2014, 1.5 million people died of tuberculosis (TB) worldwide including 400,000 co-infected with HIV. TB remains a major cause of death and suffering globally, in spite of the fact that it is supposed to be a curable disease. Drug resistant forms of TB have developed as a result of poor treatment compliance including multi-drug and extreme drug resistant forms that take longer to treat and have higher likelihoods of treatment failure. In 2010, at the initiation of the TB community, a partnership was formed between the WHO Stop TB Program, the Worldwide Hospice Palliative Care Alliance, and the Open Society Foundation's International Palliative Care Initiative (OSF/IPCI) to explore how to improve the ability of TB professionals to deliver palliative care to their patients...
August 7, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28797853/european-association-for-palliative-care-forging-a-vision-of-excellence-in-palliative-care-in-central-and-eastern-european-and-former-sovjet-union-countries-cee-fsu
#18
Lukas Radbruch, Julie Ling, Katalin Hegedus, Philip Larkin
The European Association for Palliative Care (EAPC) represents many thousands of health care workers and volunteers working in or with an interest in palliative care. In 2016, the EAPC has individual members from 48 nations across the world, and collective members from 57 national palliative care associations in 32 European Countries. Throughout its history, the EAPC has produced guidance on a range of palliative care issues. The biennial congresses and research congresses and the comprehensive website (www...
August 7, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28781930/coronal-and-heliospheric-magnetic-flux-circulation-and-its-relation-to-open-solar-flux-evolution
#19
Mike Lockwood, Mathew J Owens, Suzanne M Imber, Matthew K James, Emma J Bunce, Timothy K Yeoman
Solar cycle 24 is notable for three features that can be found in previous cycles but which have been unusually prominent: (1) sunspot activity was considerably greater in the northern/southern hemisphere during the rising/declining phase; (2) accumulation of open solar flux (OSF) during the rising phase was modest, but rapid in the early declining phase; (3) the heliospheric current sheet (HCS) tilt showed large fluctuations. We show that these features had a major influence on the progression of the cycle...
June 2017: Journal of Geophysical Research. Space Physics
https://www.readbyqxmd.com/read/28767421/periostin-promotes-epithelial-mesenchymal-transition-via-the-mapk-mir-381-axis-in-lung-cancer
#20
Wei-Wei Hu, Po-Chun Chen, Jun-Ming Chen, Yue-Ming Wu, Po-Yi Liu, Chih-Hao Lu, Yu-Feng Lin, Chih-Hsin Tang, Chia-Chia Chao
Periostin (POSTN, PN, or osteoblast-specific factor OSF-2) is a multifunctional cytokine that signals between the cell and the extracellular matrix. Periostin plays an important role in tumor development and is involved in carcinoma cell epithelial-mesenchymal transition (EMT), whereby mature epithelial cells undergo phenotypic morphological changes and become invasive, motile cells. Here, we discuss the molecular mechanisms involved in periostin-induced promotion of EMT in lung cancer cells. Online TCGA datasets demonstrate the prognostic relevance of periostin in lung cancer; a higher periostin level correlates with poor overall survival...
July 15, 2017: Oncotarget
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