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https://www.readbyqxmd.com/read/28209945/effects-of-static-cold-storage-and-hypothermic-machine-perfusion-on-oxidative-stress-factors-adhesion-molecules-and-zinc-finger-transcription-factor-proteins-before-and-after-liver-transplantation
#1
De-Fang Zhao, Qin Dong, Tong Zhang
BACKGROUND This study aimed to investigate the effects of static cold storage (SCS) and hypothermic machine perfusion (HMP) on the oxidative stress factors (OSF), adhesion molecules (AM), and zinc finger transcription factor (Snail) before and after liver transplantation. MATERIAL AND METHODS Experimental dogs were randomly divided into donor (group A), SCS (group B), and HMP (group C) (n=30) groups. Livers retrieved from group A were transplanted into group B after SCS, and the livers sampled from group B were transplanted into group C after HMP...
February 17, 2017: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/28123989/formulation-development-and-evaluation-of-zolmitriptan-oral-soluble-films-using-2-2-factorial-designs
#2
Poluri Koteswari, G Puja Sravanthi, M Mounika, S K Mohammed Rafi, K Nirosha
OBJECTIVE: The present investigation involves the development of zolmitriptan oral soluble film (OSF) formulations and optimization with quality by design (QBD) using natural polymers and evaluation. MATERIALS AND METHODS: Initially, various natural polymers such as sodium alginate, pectin, and gelatin were screened by casting films using solvent casting technique and the prepared films were evaluated. Based on the physical and mechanical properties, sodium alginate was selected as best film former and zolmitriptan-loaded films were casted...
October 2016: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28104709/utility-of-social-media-and-crowd-sourced-data-for-pharmacovigilance-a-scoping-review-protocol
#3
Andrea C Tricco, Wasifa Zarin, Erin Lillie, Ba Pham, Sharon E Straus
INTRODUCTION: Adverse events associated with medications are under-reported in postmarketing surveillance systems. A systematic review of published data from 37 studies worldwide (including Canada) found the median under-reporting rate of adverse events to be 94% in spontaneous reporting systems. This scoping review aims to assess the utility of social media and crowd-sourced data to detect and monitor adverse events related to health products including pharmaceuticals, medical devices, biologics and natural health products...
January 19, 2017: BMJ Open
https://www.readbyqxmd.com/read/28072989/-clinical-effectiveness-of-salvianolic-acid-b-and-triamcinolone-acetonide-in-treatment-of-oral-submucous-fibrosis
#4
X C Jian, L Zheng, R Zhu, B P Wang, T Zhou, Y X Du
Objective: To evaluate the clinical effectiveness of salvianolic acid B (SA-B) and triamcinolone acetonide (TA) by means of combined intralesional injection in the treatment of oral submucous fibrosis (OSF). Methods: According to clinical findings and symptoms, TA combined with SA-B were consecutively applied intralesionally 1 time weekly for 30 times. Mouth opening degree, color change of the buccal mucosae and numeral increase of the capillary vessels were determined by degree Ⅰ-Ⅳ visual analog scale were evaluated at 12, 24, and 36 months, respectively...
January 9, 2017: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/28027413/omega-3-a-novel-treatment-agent-in-oral-submucous-fibrosis-a-pilot-study
#5
Milanjeet Kaur Raizada, Digamber M Sable, Asha Chowdhery, Mahesh Shivaji Chavan, Ladu Singh Rajpurohit
BACKGROUND: Oral submucous fibrosis (OSF) is a chronic debilitating disease and a premalignant condition of the oral cavity. It is well known for its impervious nature to medical therapy. Omega 3 polyunsaturated fatty acids have been reported to have anti inflammatory properties. However, its role in OSF is still not known. This preliminary study assessed the efficacy of systemic omega 3 in this disease. METHODS: A randomized single blinded controlled trial was designed and a total of 10 clinically confirmed adult patients of OSF were included in the study...
December 27, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27987392/urinary-metabolic-profiling-of-cisplatin-nephrotoxicity-and-nephroprotective-effects-of-orthosiphon-stamineus-leaves-elucidated-by-1-h-nmr-spectroscopy
#6
Raghunath Pariyani, Intan Safinar Ismail, Amalina Azam, Alfi Khatib, Faridah Abas, Khozirah Shaari, Hazilawati Hamza
Orthosiphon stamineus (OS) is a popular medicinal herb used in traditional Chinese medicine as a diuretic agent and for renal system disorders. This study employed (1)H NMR based metabolomics approach to investigate the possible protective activity of OS in cisplatin induced nephrotoxicity owing to its diuretic and antioxidant activities. Aqueous (OSAE) and 50% aqueous ethanolic (OSFE) extracts of OS leaves were orally administered at 400mg/kg BW doses to rats which were then intraperitoneally injected with cisplatin at 5mg/kg BW dose...
December 8, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27982081/a-cloud-based-workflow-to-quantify-transcript-expression-levels-in-public-cancer-compendia
#7
P J Tatlow, Stephen R Piccolo
Public compendia of sequencing data are now measured in petabytes. Accordingly, it is infeasible for researchers to transfer these data to local computers. Recently, the National Cancer Institute began exploring opportunities to work with molecular data in cloud-computing environments. With this approach, it becomes possible for scientists to take their tools to the data and thereby avoid large data transfers. It also becomes feasible to scale computing resources to the needs of a given analysis. We quantified transcript-expression levels for 12,307 RNA-Sequencing samples from the Cancer Cell Line Encyclopedia and The Cancer Genome Atlas...
December 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27965488/rebamipide-to-manage-stomatopyrosis-in-oral-submucous-fibrosis
#8
Joanna Baptist, Shrijana Shakya, Ravikiran Ongole
INTRODUCTION: Oral submucous fibrosis (OSF) causes progressive debilitating symptoms, such as oral burning sensation (stomatopyrosis) and limited mouth opening. The standard of care (SOC) protocol includes habit cessation, intralesional steroid and hyaluronidase injections, and mouth opening exercises. The objective of the study was to evaluate efficacy of rebamipide in alleviating burning sensation of the oral mucosa in OSF in comparison with SOC intralesional steroid injections. MATERIALS AND METHODS: Twenty OSF patients were divided into two groups [rebamipide (100 mg TID for 21 days) and betamethasone (4 mg/mL biweekly for 4 weeks)] of 10 each by random sampling...
December 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27959428/expression-pattern-of-dkk3-dickkopf-wnt-signaling-pathway-inhibitor%C3%A2-3-in-the-malignant-progression-of-oral-submucous-fibrosis
#9
Shanghui Zhou, Yun Zhu, Mubarak Mashrah, Xinyu Zhang, Zhijing He, Zhigang Yao, Chunye Zhang, Feng Guo, Yongjie Hu, Chenping Zhang
Oral squamous cell carcinoma (OSCC) is a common malignant neoplasm of the head and neck. Oral submucous fibrosis (OSF) is one of its pre-cancerous lesions; however, the key molecular events in the tumorigenesis of OSF remain elusive. Dickkopf WNT signaling pathway inhibitor 3 (DKK3) is one of the Wnt antagonists, and its downregulation and methylation have been reported in multiple malignancies, while no report of its expression in the carcinogenesis of OSF exists. In the present study, we investigated DKK3 expression at the protein and mRNA levels by immunochemical staining and semi‑quantitative RT-PCR in normal oral, OSF and OSCC tissues...
February 2017: Oncology Reports
https://www.readbyqxmd.com/read/27910776/molecular-pathology-of-malignant-transformation-of-oral-submucous-fibrosis
#10
REVIEW
Amit Chattopadhyay, Jay Gopal Ray
Oral submucous fibrosis (OSF) is prevalent mostly in Southeast Asia, particularly in the Indian subcontinent. Chewing betel nuts and betel leaves, with or without tobacco, has been associated with OSF. Betel quid contents including guvacine, arecoline, guvacoline, arecaidine, and chavibetol are considered to play an important part in the occurrence of OSF. Transformation of OSF to squamous cell carcinoma (SCC) is variable, but up to 13% conversion of OSF to SCC has been reported. Various genetic and molecular mechanisms impact the malignant transformation of OSF, causing changes in the cell cycle, DNA, keratinocytes, and keratin; tumor-cell proliferation and survival; angiogenesis; fibrosis through epithelial-mesenchymal transitions (EMTs), and tissue hypoxia...
2016: Journal of Environmental Pathology, Toxicology and Oncology
https://www.readbyqxmd.com/read/27869455/an-interference-model-of-visual-working-memory
#11
Klaus Oberauer, Hsuan-Yu Lin
The article introduces an interference model of working memory for information in a continuous similarity space, such as the features of visual objects. The model incorporates the following assumptions: (a) Probability of retrieval is determined by the relative activation of each retrieval candidate at the time of retrieval; (b) activation comes from 3 sources in memory: cue-based retrieval using context cues, context-independent memory for relevant contents, and noise; (c) 1 memory object and its context can be held in the focus of attention, where it is represented with higher precision, and partly shielded against interference...
January 2017: Psychological Review
https://www.readbyqxmd.com/read/27851781/characterization-of-a-novel-dermal-fibrosis-model-induced-by-areca-nut-extract-that-mimics-oral-submucous-fibrosis
#12
Min-Hsuan Chiang, Ping-Ho Chen, Yuk-Kwan Chen, Chia-Hsin Chen, Mei-Ling Ho, Yan-Hsiung Wang
Oral submucous fibrosis (OSF) is an oral potentially malignant disorder and areca quid chewing is the main etiological factor. However, the molecular mechanism underlying OSF remains unclear, partly due to the lack of an appropriate animal model. The present study aimed to establish and characterize an animal model of areca nut extract (ANE)-induced skin fibrosis that mimics OSF. Mice were divided into 4 groups: the control group; the bleomycin group; and the ANE10 and ANE20 groups, which received 10mg/ml and 20mg/ml subcutaneous (SC) injection of ANE, respectively...
2016: PloS One
https://www.readbyqxmd.com/read/27845370/aberrant-ssea-4-upregulation-mediates-myofibroblast-activity-to-promote-pre-cancerous-oral-submucous-fibrosis
#13
Cheng-Chia Yu, Chuan-Hang Yu, Yu-Chao Chang
Oral submucous fibrosis (OSF), regarded as a precancerous condition, is characterized by juxta-epithelial inflammatory reaction followed by fibro-elastic change in the lamina properia and epithelial atrophy. The pathologic mechanisms of OSF still need to be further clarified. In the study, we investigated the functional expression of SSEA-4, which is a well-known stemness marker, in myofibroblast activity and the clinical significance in OSF tissues. The expression of SSEA-4 in OSF was evaluated by immunohistochemical staining...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27779604/the-prediction-and-prevention-of-dysphagia-after-occipitospinal-fusion-by-use-of-the-s-line-swallowing-line
#14
Shuichi Kaneyama, Masatoshi Sumi, Masato Takabatake, Koichi Kasahara, Aritetsu Kanemura, Hiroaki Hirata, Bruce V Darden
STUDY DESIGN: Clinical case series and risk factor analysis of dysphagia after occipitospinal fusion (OSF). OBJECTIVE: To develop new criteria to avoid postoperative dysphagia by analyzing the relationship among the craniocervical alignment, the oropharyngeal space and the incidence of dysphagia after OSF. SUMMARY OF BACKGROUND DATA: Craniocervical malalignment after OSF is considered to be one of the primary triggers of postoperative dysphagia...
October 24, 2016: Spine
https://www.readbyqxmd.com/read/27777969/a-study-to-analyze-different-patterns-of-quid-usage-among-subjects-with-oral-submucous-fibrosis-in-mangalore-population
#15
Vidya A Holla, L K Chatra, Prashanth Shenai, Devika Shetty, Ashwini Baliga
Aim and Objectives. Oral submucous fibrosis (OSF) is a potentially malignant disorder associated with the usage of areca nut. Usage of processed forms of areca nut is popular among the youth and its carcinogenic effects are not well known. Due to large immigrant population, various patterns of areca nut usage are seen. The aim of this study is to assess the various quid chewing patterns and their association with severity of OSF. Materials and Methods. A cross-sectional study was carried out with 250 cases clinically and histologically diagnosed as having OSF lesion that were selected and subjected to a detailed habit history which was recorded through preformed questionnaire...
2016: Advances in Medicine
https://www.readbyqxmd.com/read/27769912/expression-of-fibrosis-related-molecules-in-the-oral-mucosa-of-six-animal-species-a-reference-for-selecting-animal-models
#16
Guoliang Sa, Xuepeng Xiong, Jiangang Ren, Yifang Zhao, Sangang He
Several animal models have been used in studies associated with oral submucous fibrosis (OSF); however, an appropriate model based on the histopathological characteristics of OSF is still needed. This study aimed to provide histological references for selecting a potential model. The expression intensities of collagen type I (Col I), type III (Col III), type IV (Col IV), fibronectin (FN), transforming growth factors β (TGF-β), and connective tissue growth factor (CCN2) in the oral mucosa of the human and six non-human animal species were measured by immunohistochemistry...
January 1, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27750161/nanomechanical-signatures-of-oral-submucous-fibrosis-in-sub-epithelial-connective-tissue
#17
Anji Anura, Debanjan Das, Mousumi Pal, Ranjan Rashmi Paul, Soumen Das, Jyotirmoy Chatterjee
Oral sub-mucous fibrosis (OSF), a potentially malignant disorder, exhibits extensive remodeling of extra-cellular matrix in the form of sub-epithelial fibrosis which is a possible sequel of assaults from different oral habit related irritants. It has been assumed that micro/nanobio-mechanical imbalance experienced in the oral mucosa due to fibrosis may be deterministic for malignant potential (7-13%) of this pathosis. Present study explores changes in mechanobiological attributes of sub-epithelial connective tissue of OSF and the normal counterpart...
January 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27743497/limited-mouth-opening-in-oral-submucous-fibrosis-reasons-ramifications-and-remedies
#18
Mohit Sharma, Raghu Radhakrishnan
Limited mouth opening (LMO) in Oral Submucous Fibrosis (OSF) has been attributed to both the submucosal and muscle fibrosis (MF). While, reflectory trismus was proposed before as an auxiliary mechanism by another group; the stretch mediated muscle damage (MSD), histopathological changes in blood vessels (like endothelial dysfunction, endothelial hypertrophy and endarteritis obliterans) and upregulated anaerobic isoforms of lactate dehydrogenase (LDH), have been proposed by us as complementary events leading to MF...
October 15, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27739057/increased-chondrogenic-potential-of-mesenchymal-cells-from-adipose-tissue-versus-bone-marrow-derived-cells-in-osteoarthritic-in-vitro-models
#19
Stefania Pagani, Veronica Borsari, Francesca Veronesi, Andrea Ferrari, Simona Cepollaro, Paola Torricelli, Giuseppe Filardo, Milena Fini
OBJECTIVES: Primarily, to compare the behavior of human mesenchymal stem cells (MSCs) derived from bone marrow (hBMSCs) and adipose tissue (hADSCs) in an osteoarthritic (OA) microenvironment; secondly, to investigate the reaction of these cell types in two alternative in vitro culture systems, obtained by using TNFα and/or IL1β as inflammation mediators, or by using synovial fluid harvested by OA patients (OSF) to simulate the complex inflamed knee microenvironment. METHODS: 3D micromass cultures of hBMSCs or hADSCs were grown in chondrogenic medium (CTR), in the presence of TNFα and/or IL1β, or synovial fluid from OA patients...
October 14, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27722225/implants-inserted-with-graftless-osteotome-sinus-floor-elevation-a-5-year-post-loading-retrospective-study
#20
Alexander Zill, Clarissa Precht, Benedicta Beck-Broichsitter, Susanne Sehner, Ralf Smeets, Max Heiland, Carsten Rendenbach, Anders Henningsen
PURPOSE: To report the outcome of graftless osteotome sinus floor elevation (OSFE) in order to evaluate whether apical bone gain depends on the initial residual bone height and whether the initial residual bone height has an influence on the amount of marginal bone loss. Furthermore the study aimed to assess if perforations of the Schneiderian membrane or residual bone height are potential predictors of implant survival. MATERIALS AND METHODS: In this retrospective study all patients were included who were treated between 2001 and 2010 and received dental implants in combination with OSFE in a private practice...
2016: European Journal of Oral Implantology
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