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https://www.readbyqxmd.com/read/29696422/mouth-opening-device-as-a-treatment-modality-in-trismus-patients-with-head-and-neck-cancer-and-oral-submucous-fibrosis-a-prospective-study
#1
Yu-Hsuan Li, Wei-Chin Chang, Tien-En Chiang, Chiun-Shu Lin, Yuan-Wu Chen
OBJECTIVES: This study investigated the clinical effectiveness of intervention with an open-mouth exercise device designed to facilitate maximal interincisal opening (MIO) and improve quality of life in patients with head and neck (H&N) cancer and oral submucous fibrosis (OSF). MATERIALS AND METHODS: Sixty patients with H&N cancer, OSF, and trismus (MIO < 35 mm) participated in the functional rehabilitation program. An open-mouth exercise device intervention group and conventional group, each consisting of 20 patients, underwent a 12-week training and exercising program and follow-up...
April 26, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29687243/endorsing-cellular-competitiveness-in-aberrant-epithelium-of-oral-submucous-fibrosis-progression-neighbourhood-analysis-of-immunohistochemical-attributes
#2
Anji Anura, Anees Kazi, Mousumi Pal, Ranjan Rashmi Paul, Sanghamitra Sengupta, Jyotirmoy Chatterjee
Epithelial abnormality during the transformation of oral submucous fibrosis (OSF) into oral squamous cell carcinoma has been well studied and documented. However, the differential contribution of atrophy and hyperplasia for malignant potentiality of OSF is yet to be resolved. Existing diagnostic conjectures lack precise diagnostic attributes which may be effectively resolved by substantiation of specific molecular pathology signatures. Present study elucidates existence of cellular competitiveness in OSF conditions using computer-assisted neighbourhood analysis in quantitative immunohistochemistry (IHC) framework...
April 23, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29672110/-the-empathy-impulse-a-multinomial-model-of-intentional-and-unintentional-empathy-for-pain-correction
#3
(no author information available yet)
Reports an error in "The empathy impulse: A multinomial model of intentional and unintentional empathy for pain" by C. Daryl Cameron, Victoria L. Spring and Andrew R. Todd ( Emotion , 2017[Apr], Vol 17[3], 395-411). In this article, there was an error in the calculation of some of the effect sizes. The w effect size was manually computed incorrectly. The incorrect number of total observations was used, which affected the final effect size estimates. This computing error does not change any of the results or interpretations about model fit based on the G² statistic, or about significant differences across conditions in process parameters...
April 2018: Emotion
https://www.readbyqxmd.com/read/29666597/a-computational-model-of-working-memory-integrating-time-based-decay-and-interference
#4
Benoît Lemaire, Sophie Portrat
There is still a strong debate in the working memory literature about the cause of forgetting, with many articles providing evidence for the existence of temporal decay and as many publications providing evidence compatible with interference being the only mechanism involved in forgetting. In order to reconcile the two views, this article describes TBRS∗ -I (for Time-Based Resource-Sharing∗ -Interference), a computational model of working memory which incorporates an interference-based mechanism to the decay-based implementation TBRS∗ within the TBRS theoretical framework...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29665273/butylidenephthalide-abrogates-the-myofibroblasts-activation-and-mesenchymal-transdifferentiation-in-oral-submucous-fibrosis
#5
Tzu-Rong Su, Yi-Wen Liao, Pei-Ling Hsieh, Lo-Lin Tsai, Chih-Yuan Fang, Taichen Lin, Yu-Hsien Lee, Horng-Jyh Harn, Cheng-Chia Yu
Oral submucous fibrosis (OSF) is a premalignant disorder in the oral cavity, and areca nut chewing habit has been implicated in the persistent activation of myofibroblasts and the subsequent fibrosis. Therefore, it is critical to ameliorate the excessive activities of myofibroblasts prior to the malignant transformation of OSF. In the current study, we evaluated the cytotoxicity of butylidenephthalide (BP), a major phthalide ingredient of Angelica sinensis, in fibrotic buccal mucosal fibroblasts (fBMFs) as well as various myofibroblast hallmarks, including the phenotypical characteristics and fibrosis-related markers...
April 17, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29606916/sayette-group-formation-task-gft-spontaneous-facial-expression-database
#6
Jeffrey M Girard, Wen-Sheng Chu, László A Jeni, Jeffrey F Cohn, Fernando De la Torre, Michael A Sayette
Despite the important role that facial expressions play in interpersonal communication and our knowledge that interpersonal behavior is influenced by social context, no currently available facial expression database includes multiple interacting participants. The Sayette Group Formation Task (GFT) database addresses the need for well-annotated video of multiple participants during unscripted interactions. The database includes 172,800 video frames from 96 participants in 32 three-person groups. To aid in the development of automated facial expression analysis systems, GFT includes expert annotations of FACS occurrence and intensity, facial landmark tracking, and baseline results for linear SVM, deep learning, active patch learning, and personalized classification...
May 2017: Proceedings of the ... International Conference on Automatic Face and Gesture Recognition
https://www.readbyqxmd.com/read/29603708/quality-of-life-related-patient-reported-outcome-measures-in-oral-submucous-fibrosis-patients
#7
Shailesh M Gondivkar, Rahul R Bhowate, Amol R Gadbail, Sachin C Sarode, Rima S Gondivkar, Monal Yuwanati, Shankargouda Patil
AIM: The aim of this study was to explore the patients' perspectives about the impact of oral submucous fibrosis (OSF) on life quality. MATERIALS AND METHODS: Thirty clinically diagnosed OSF patients with a wide degree of disease severity and diverse range of sociodemographic profile were included in this study. Fourteen participants were interviewed and four focus group discussions were conducted in nonclinical settings. The audio recordings were anonymized, transcribed, and translated in English from Marathi language...
March 1, 2018: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29589333/effect-of-response-format-on-cognitive-reflection-validating-a-two-and-four-option-multiple-choice-question-version-of-the-cognitive-reflection-test
#8
Miroslav Sirota, Marie Juanchich
The Cognitive Reflection Test, measuring intuition inhibition and cognitive reflection, has become extremely popular because it reliably predicts reasoning performance, decision-making, and beliefs. Across studies, the response format of CRT items sometimes differs, based on the assumed construct equivalence of tests with open-ended versus multiple-choice items (the equivalence hypothesis). Evidence and theoretical reasons, however, suggest that the cognitive processes measured by these response formats and their associated performances might differ (the nonequivalence hypothesis)...
March 27, 2018: Behavior Research Methods
https://www.readbyqxmd.com/read/29570905/development-validation-of-oral-health-related-quality-of-life-measure-in-oral-submucous-fibrosis
#9
Shailesh M Gondivkar, Rahul R Bhowate, Amol R Gadbail, Rahul N Gaikwad, Rima S Gondivkar, Sachin C Sarode, Gargi S Sarode
OBJECTIVE: The aim of this study was to develop and assess the validity and reliability of disease-specific oral health related quality of life (OHRQoL) instrument for oral submucous fibrosis (OSF). MATERIALS AND METHODS: Items for the OHRQoL-OSF were generated from personal interviews and focus group discussions, the existing questionnaires, reviews of literature and inputs from expert's panel. Item reduction was performed by clinical impact method followed by pretesting of the developed questionnaire...
March 23, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29562901/beliefs-and-attitudes-about-addressing-alcohol-consumption-in-health-care-a-population-survey-in-england
#10
Amy O'Donnell, Latifa Abidi, Jamie Brown, Nadine Karlsson, Per Nilsen, Kerstin Roback, Janna Skagerström, Kristin Thomas
BACKGROUND: Despite robust evidence for their effectiveness, it has proven difficult to translate alcohol prevention activities into routine health care practice. Previous research has identified numerous provider-level barriers affecting implementation, but these have been less extensively investigated in the wider population. We sought to: (1) investigate patients' beliefs and attitudes to being asked about alcohol consumption in health care; and (2) identify the characteristics of those who are supportive of addressing alcohol consumption in health care...
March 21, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29560273/large-scale-computational-drug-repositioning-to-find-treatments-for-rare-diseases
#11
Rajiv Gandhi Govindaraj, Misagh Naderi, Manali Singha, Jeffrey Lemoine, Michal Brylinski
Rare, or orphan, diseases are conditions afflicting a small subset of people in a population. Although these disorders collectively pose significant health care problems, drug companies require government incentives to develop drugs for rare diseases due to extremely limited individual markets. Computer-aided drug repositioning, i.e., finding new indications for existing drugs, is a cheaper and faster alternative to traditional drug discovery offering a promising venue for orphan drug research. Structure-based matching of drug-binding pockets is among the most promising computational techniques to inform drug repositioning...
2018: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/29533182/replication-study-fusobacterium-nucleatum-infection-is-prevalent-in-human-colorectal-carcinoma
#12
John Repass, Elizabeth Iorns, Alexandria Denis, Stephen R Williams, Nicole Perfito, Timothy M Errington
As part of the <ext-link ext-link-type="uri" xlink:href="https://osf.io/e81xl/wiki/home/">Reproducibility Project: Cancer Biology</ext-link>, we published a Registered Report (Repass et al., 2016), that described how we intended to replicate an experiment from the paper ' Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma' (Castellarin et al., 2012). Here we report the results. When measuring Fusobacterium nucleatum DNA by qPCR in colorectal carcinoma (CRC), adjacent normal tissue, and separate matched control tissue, we did not detect a signal for F...
March 13, 2018: ELife
https://www.readbyqxmd.com/read/29523428/differential-expression-of-organic-cation-transporter-3-in-oral-submucous-fibrosis-associated-buccal-squamous-cell-carcinoma
#13
Yue Hu, Yunmei Qian, Lu Lin, Wenxin Chen, Liudi Yang, Xin Hu, Ke Tian, Kun Xia, Tong Su
OBJECTIVE: The aim of this study was to examine the expression of organic cation transporter 3 (OCT3) in patients with oral submucous fibrosis (OSF)-associated buccal squamous cell carcinoma (BSCC) and to explore its clinical significance. STUDY DESIGN: A total of 56 tissue specimens were collected from patients, among which there were 13 specimens with normal buccal mucosa (NBM), 13 with oral submucous fibrosis (OSF), 10 with OSF-associated BSCC (BSCC-OSF), 10 with well-differentiated BSCC (BSCC-I), and 10 with poorly to moderately differentiated BSCC (BSCC-II+III), based on pathologic examination...
March 6, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29523085/comparative-assessment-of-strategies-to-identify-similar-ligand-binding-pockets-in-proteins
#14
Rajiv Gandhi Govindaraj, Michal Brylinski
BACKGROUND: Detecting similar ligand-binding sites in globally unrelated proteins has a wide range of applications in modern drug discovery, including drug repurposing, the prediction of side effects, and drug-target interactions. Although a number of techniques to compare binding pockets have been developed, this problem still poses significant challenges. RESULTS: We evaluate the performance of three algorithms to calculate similarities between ligand-binding sites, APoc, SiteEngine, and G-LoSA...
March 9, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29489008/a-bead-spring-chain-as-a-one-dimensional-polyelectrolyte-gel
#15
Gerald S Manning
The physical principles underlying expansion of a single-chain polyelectrolyte coil caused by Coulomb repulsions among its ionized groups, and the expansion of a cross-linked polyelectrolyte gel, are probably the same. In this paper, we analyze a "one-dimensional" version of a gel, namely, a linear chain of charged beads connected by Hooke's law springs. In the Debye-Hückel range of relatively weak Coulomb strength, where counterion condensation does not occur, the springs are realistically stretched on a nanolength scale by the repulsive interactions among the beads, if we use a spring constant normalized by the inverse square of the solvent Bjerrum length...
February 28, 2018: Soft Matter
https://www.readbyqxmd.com/read/29457855/experimental-study-on-tgf-%C3%AE-1-mediated-cd147-expression-in-oral-submucous-fibrosis
#16
Weiming Wang, Haofeng Xiong, Zhengmao Hu, Rongjuan Zhao, Yue Hu, Wenxin Chen, Ying Han, Liudi Yang, Xin Hu, Can Wang, Ting Mao, Kun Xia, Tong Su
OBJECTIVE: Although previous evidence indicates that CD147 is closely involved in the progression of organ fibrosis and various signaling pathways have been proven to regulate its expression, the role of CD147 in oral submucous fibrosis (OSF) remain largely unknown. METHODS: In the present study, we investigated the expression of CD147 and transforming growth factor β1 (TGF-β1) in human samples of an OSF tissue array by immunohistopathology. Pearson's correlation analysis was conducted to explore the correlation between CD147 and TGF-β1...
February 19, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29440066/data-sharing-and-reanalysis-of-randomized-controlled-trials-in-leading-biomedical-journals-with-a-full-data-sharing-policy-survey-of-studies-published-in-the-bmj-and-plos-medicine
#17
REVIEW
Florian Naudet, Charlotte Sakarovitch, Perrine Janiaud, Ioana Cristea, Daniele Fanelli, David Moher, John P A Ioannidis
OBJECTIVES: To explore the effectiveness of data sharing by randomized controlled trials (RCTs) in journals with a full data sharing policy and to describe potential difficulties encountered in the process of performing reanalyses of the primary outcomes. DESIGN: Survey of published RCTs. SETTING: PubMed/Medline. ELIGIBILITY CRITERIA: RCTs that had been submitted and published by The BMJ and PLOS Medicine subsequent to the adoption of data sharing policies by these journals...
February 13, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29433543/engaging-policy-makers-heath-system-managers-and-policy-analysts-in-the-knowledge-synthesis-process-a-scoping-review
#18
Andrea C Tricco, Wasifa Zarin, Patricia Rios, Vera Nincic, Paul A Khan, Marco Ghassemi, Sanober Diaz, Ba' Pham, Sharon E Straus, Etienne V Langlois
BACKGROUND: It is unclear how to engage a wide range of knowledge users in research. We aimed to map the evidence on engaging knowledge users with an emphasis on policy-makers, health system managers, and policy analysts in the knowledge synthesis process through a scoping review. METHODS: We used the Joanna Briggs Institute guidance for scoping reviews. Nine electronic databases (e.g., MEDLINE), two grey literature sources (e.g., OpenSIGLE), and reference lists of relevant systematic reviews were searched from 1996 to August 2016...
February 12, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29428194/malignant-transformation-of-taiwanese-patients-with-oral-leukoplakia-a-nationwide-population-based-retrospective-cohort-study
#19
Tung-Yuan Wang, Yu-Wei Chiu, Yi-Tzu Chen, Yu-Hsun Wang, Hui-Chieh Yu, Chuan-Hang Yu, Yu-Chao Chang
BACKGROUND/PURPOSE: Oral leukoplakia (OL) is one of the clinically diagnosed oral potentially malignant disorders (OPMDs) with an increased risk of oral cancer development. In this study, we investigated the malignant transformation of OL in Taiwanese population. METHODS: A retrospective cohort study was analyzed from Taiwan's National Health Insurance Research Database. A comparison cohort was randomly frequency-matched with the OL cohort according to age, sex, and index year...
May 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29422478/angiogenesis-and-fibrogenesis-in-oral-submucous-fibrosis-a-viewpoint
#20
Sheetal S Choudhari, Deepak G Kulkarni, Sangeeta Patankar, Supriya M Kheur, Sachin C Sarode, Gargi S Sarode, Shankargouda Patil
Oral submucous fibrosis (OSF) is characterized by excessive fibrosis of submucosa. The degree of vascularity in OSF has always been a matter of debate. Angiogenesis is the key mechanism involved in regeneration and repair. It also plays an important role in various pathologic conditions. Angiogenesis may contribute to the progression of fibrosis in fibrotic disorders. Inhibition of pathological angiogenesis is considered to be a new strategy for the treatment of various fibrotic disorders. In OSF, angiogenesis can be related to progression fibrosis...
February 1, 2018: Journal of Contemporary Dental Practice
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