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https://www.readbyqxmd.com/read/28732399/analysis-of-emerging-organic-contaminants-in-water-fish-and-suspended-particulate-matter-spm-in-the-joint-danube-survey-using-solid-phase-extraction-followed-by-uhplc-ms-ms-and-gc-ms-analysis
#1
Robert Loos, Simona Tavazzi, Giulio Mariani, Gert Suurkuusk, Bruno Paracchini, Gunther Umlauf
In the third Joint Danube Survey (JDS3), emerging organic contaminants were analysed in the dissolved water phase of samples from the Danube River and its major tributaries. Analyses were performed using solid-phase extraction (SPE) followed by ultra-high-pressure liquid chromatography triple-quadrupole mass spectrometry (UHPLC-MS-MS) and gas chromatography-mass spectrometry (GC-MS). The polar organic compounds analysed by UHPLC-MS-MS were 1H-benzotriazole, methylbenzotriazoles, carbamazepine, 10,11-dihydro-10,11-dihydroxy-carbamazepine, diclofenac, sulfamethox-azole, 2,4-D (2,4-dichlorophenoxyacetic acid), MCPA (2-methyl-4-chlorophenoxyacetic acid), metolachlor, cybutryne (irgarol), terbutryn, DEET (N,N-diethyl-m-toluamide), and several perfluoroalkyl acids (C6-C9; C8=perfluorooctanoic acid (PFOA)) and perfluorooctansulfonic acid (PFOS)...
July 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28732239/effects-of-antiepileptic-drugs-on-mitochondrial-functions-morphology-kinetics-biogenesis-and-survival
#2
REVIEW
Josef Finsterer, Fulvio A Scorza
OBJECTIVES: Antiepileptic drugs (AEDs) exhibit adverse and beneficial effects on mitochondria, which have a strong impact on the treatment of patients with a mitochondrial disorder (MID) with epilepsy (mitochondrial epilepsy). This review aims at summarizing and discussing recent findings concerning the effect of AEDs on mitochondrial functions and the clinical consequences with regard to therapy of mitochondrial epilepsy and of MIDs in general. METHODS: Literature review...
July 13, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28731977/interventions-for-neuropathic-pain-an-overview-of-systematic-reviews
#3
Svjetlana Dosenovic, Antonia Jelicic Kadic, Maja Miljanovic, Marina Biocic, Krste Boric, Marija Cavar, Nikolina Markovina, Katarina Vucic, Livia Puljak
Numerous interventions for neuropathic pain (NeuP) are available, but its treatment remains unsatisfactory. We systematically summarized evidence from systematic reviews (SRs) of randomized controlled trials on interventions for NeuP. Five electronic databases were searched up to March 2015. Study quality was analyzed using A Measurement Tool to Assess Systematic Reviews. The most common interventions in 97 included SRs were pharmacologic (59%) and surgical (15%). The majority of analyzed SRs were of medium quality...
August 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28729910/drug-induced-gingival-hyperplasia-a-retrospective-study-using-spontaneous-reporting-system-databases
#4
Haruna Hatahira, Junko Abe, Yuuki Hane, Toshinobu Matsui, Sayaka Sasaoka, Yumi Motooka, Shiori Hasegawa, Akiho Fukuda, Misa Naganuma, Tomofumi Ohmori, Yasutomi Kinosada, Mitsuhiro Nakamura
BACKGROUND: Drug-induced gingival hyperplasia (DIGH) causes problems with chewing, aesthetics, and pronunciation, and leads to the deterioration of the patient's quality of life (QOL). Thus, the aim of this study was to evaluate the incidence of DIGH using spontaneous reporting system (SRS) databases. METHODS: We analyzed reports of DIGH from SRS databases and calculated the reporting odds ratios (RORs) of suspected drugs (immunosuppressants, calcium channel blockers, and anticonvulsants)...
2017: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/28729328/comparative-safety-of-antiepileptic-drugs-for-neurological-development-in-children-exposed-during-pregnancy-and-breast-feeding-a-systematic-review-and-network-meta-analysis
#5
Areti Angeliki Veroniki, Patricia Rios, Elise Cogo, Sharon E Straus, Yaron Finkelstein, Ryan Kealey, Emily Reynen, Charlene Soobiah, Kednapa Thavorn, Brian Hutton, Brenda R Hemmelgarn, Fatemeh Yazdi, Jennifer D'Souza, Heather MacDonald, Andrea C Tricco
OBJECTIVES: Compare the safety of antiepileptic drugs (AEDs) on neurodevelopment of infants/children exposed in utero or during breast feeding. DESIGN AND SETTING: Systematic review and Bayesian random-effects network meta-analysis (NMA). MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials were searched until 27 April 2017. Screening, data abstraction and quality appraisal were completed in duplicate by independent reviewers. PARTICIPANTS: 29 cohort studies including 5100 infants/children...
July 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28728838/kcnq2-encephalopathy-a-case-due-to-a-de-novo-deletion
#6
Carlotta Spagnoli, Grazia Gabriella Salerno, Alessandro Iodice, Daniele Frattini, Francesco Pisani, Carlo Fusco
KCNQ2 encephalopathy is characterized by severely abnormal EEG, neonatal-onset epilepsy and developmental delay. It is caused by mutations (typically missense) in the KCNQ2 gene, encoding the voltage gated potassium channel Kv7.2 and leading to a negative-dominant effect. We present one case experiencing recurrent neonatal seizures with changing hemispheres of origin, reminiscent of epilepsy of infancy with migrating focal seizures. At 9months of age the patient is still seizure-free on carbamazepine, although he is developing a spastic-dystonic tetraplegia with severe dysphagia...
July 17, 2017: Brain & Development
https://www.readbyqxmd.com/read/28726694/characteristic-numbers-of-granular-activated-carbon-for-the-elimination-of-micropollutants-from-effluents-of-municipal-wastewater-treatment-plants
#7
F Benstoem, J Pinnekamp
Adsorption on granular activated carbon (GAC) is a promising step to extend existing treatment trains in municipal wastewater treatment plants (WWTPs) and, thus, to reduce the concentration of micropollutants (MPs) (e.g. pharmaceuticals) in wastewater. It is common practice to use characteristic numbers when choosing GAC for a specific application. In this study, characteristic numbers were correlated for five different GACs, with measured adsorption capacities of these carbons for three pharmaceutical MPs (carbamazepine, diclofenac and sulfamethoxazole) and dissolved organic carbon of a WWTP effluent...
July 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28722356/hansen-solubility-parameters-for-assay-method-optimization-of-simvastatin-ramipril-atenolol-hydrochlorothiazide-and-aspirin-in-human-plasma-using-liquid-chromatography-with-tandem-mass-spectrometry
#8
Murali Mohan Reddy Devalapalli, Hanumanth Srikanth Cheruvu, Thejaswi Yertha, Vijaya Bhaskar Veeravalli, Sunitha Sampathi, Savithri Shivakumar
A simple, specific, sensitive validated method was developed using liquid chromatography with tandem mass spectrometry with electrospray ionization of human plasma for the simultaneous estimation of drugs (simvastatin, ramipril, atenolol, hydrochlorothiazide and aspirin) of Polycap(TM) capsule used in cardiovascular therapy. The interaction of these actives including internal standards between the stationary and mobile phase were investigated using Hansen solubility parameters. Chromatographic separation was performed on Phenomenex Synergi Polar-RP (30 × 2 mm, 4 μm) column with a gradient mobile phase composition of acetonitrile and 5 mM ammonium formate for positive mode and 0...
July 19, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28721930/pharmacoresistant-epileptic-eyelid-twitching-in-a-child-with-a-mutation-in-syngap1
#9
Tetsuya Okazaki, Yoshiaki Saito, Rika Hiraiwa, Shinji Saitoh, Masachika Kai, Kaori Adachi, Yoko Nishimura, Eiji Nanba, Yoshihiro Maegaki
SYNGAP1 gene mutation has been associated with epilepsy which is often drug resistant, with seizure types including eyelid myoclonia. However, detailed descriptions, including ictal video-EEG, have not been reported. We report the case of a 4-year-old boy who developed recurrent epileptic eyelid twitching at 1 year and 5 months of age. Seizures gradually increased in frequency to more than 50 times per day and manifested with upward eye deviation, motion arrest, loss of consciousness, and eyelid twitching lasting for five seconds...
July 19, 2017: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/28718873/clinical-features-of-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome-a-study-of-25-patients-in-korea
#10
Jin Y Lee, Suh-Young Lee, Ji E Hahm, Jae W Ha, Chul W Kim, Sang S Kim
BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare adverse drug reaction. This study aimed to evaluate the incidence of association with individual drugs, clinical manifestations, disease course, and outcomes of DRESS. METHODS: Using the criteria of the European Registry of Severe Cutaneous Adverse Reactions (RegiSCAR), the medical records of 25 patients diagnosed with DRESS between 2006 and 2015 were retrospectively reviewed...
July 18, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28718026/solid-phase-extraction-of-multi-class-pharmaceuticals-from-environmental-water-samples-onto-modified-multi-walled-carbon-nanotubes-followed-by-lc-ms-ms
#11
Bojana Lalović, Tatjana Đurkić, Marija Vukčević, Ivona Janković-Častvan, Ana Kalijadis, Zoran Laušević, Mila Laušević
In this paper, pristine and chemically treated multi-walled carbon nanotubes (MWCNTs) were employed as solid-phase extraction sorbents for the isolation and enrichment of multi-class pharmaceuticals from the surface water and groundwater, prior to liquid chromatography-tandem mass spectrometry analysis. Thirteen pharmaceuticals that belong to different therapeutical classes (erythromycin, azithromycin, sulfamethoxazole, diazepam, lorazepam, carbamazepine, metoprolol, bisoprolol, enalapril, cilazapril, simvastatin, clopidogrel, diclofenac) and two metabolites of metamizole (4-acetylaminoantipyrine and 4-formylaminoantipyrine) were selected for this study...
July 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28717415/chronic-antiepileptic-drug-use-and-functional-network-efficiency-a-functional-magnetic-resonance-imaging-study
#12
Tamar M van Veenendaal, Dominique M IJff, Albert P Aldenkamp, Richard H C Lazeron, Paul A M Hofman, Anton J A de Louw, Walter H Backes, Jacobus F A Jansen
AIM: To increase our insight in the neuronal mechanisms underlying cognitive side-effects of antiepileptic drug (AED) treatment. METHODS: The relation between functional magnetic resonance-acquired brain network measures, AED use, and cognitive function was investigated. Three groups of patients with epilepsy with a different risk profile for developing cognitive side effects were included: A "low risk" category (lamotrigine or levetiracetam, n = 16), an "intermediate risk" category (carbamazepine, oxcarbazepine, phenytoin, or valproate, n = 34) and a "high risk" category (topiramate, n = 5)...
June 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28714604/antidepressants-antipsychotics-and-mood-stabilizers-in-pregnancy-what-do-we-know-and-how-should-we-treat-pregnant-women-with-depression
#13
REVIEW
Asher Ornoy, Liza Weinstein-Fudim, Zivanit Ergaz
Depression is generally treated with antidepressants, but may often need antipsychotics and mood stabilizers. We discuss the updated data regarding the safety in pregnancy of antidepressants and antipsychotics, except selective serotonin reuptake inhibitors, and their possible impact on the long-term development of the offspring. Several earlier studies demonstrated a slight increase in the rate of major anomalies following maternal tricyclic antidepressant treatment, but most current literature shows their relative safety in pregnancy...
July 17, 2017: Birth defects research
https://www.readbyqxmd.com/read/28713031/an-lc-ms-ms-based-candidate-reference-method-for-the-quantification-of-carbamazepine-in-human-serum
#14
Judith Taibon, Rupert Schmid, Stephanie Lucha, Stephan Pongratz, Kirill Tarasov, Christoph Seger, Christian Timm, Roland Thiele, Joachim Mark Herlan, Uwe Kobold
A validated LC-MS/MS-based candidate reference measurement procedure for the quantification of carbamazepine is presented in order to be used for standardization and harmonization of routine assays applied for therapeutic drug monitoring. Sample preparation was based on protein precipitation using acetonitrile followed by sample dilution. Since the previously listed certified reference material (CRM) SRM 1599 (anticonvulsant drug level assay standard) is no longer available, an ISO certified calibration material was used in this assay...
July 14, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28706399/comparative-effect-of-divided-doses-of-adult-solid-and-liquid-oral-formulations-of-antiepileptic-drugs-in-the-management-of-pediatric-epilepsy
#15
Ravi Prasad Nidanapu, Bascarane Tamijarassy, Subramanian Mahadevan, Batmanabane Gitanjali
OBJECTIVE: To compare the differences in the efficacy and safety of the commonly prescribed AEDs in the management of epilepsy in children when using divided doses of adult solid oral formulations (DDSF) with the liquid oral formulations (LFs). MATERIALS AND METHODS: Patients who had one or more seizures per month and prescribed with DDSF were recruited. Initially the patients were continued on DDSF for 4 months following which they were switched over to LF for the subsequent 4 months...
April 2017: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/28704661/direct-and-indirect-photolysis-of-seven-micropollutants-in-secondary-effluent-from-a-wastewater-lagoon
#16
Yufei Wang, Felicity A Roddick, Linhua Fan
The photodegradation of seven micropollutants commonly found in municipal wastewater, namely caffeine, carbamazepine, diuron, simazine, sulfamethoxazole, triclosan and 2,4-D, was investigated in pure water and secondary effluent to understand the direct and indirect photolysis of these compounds under natural sunlight irradiation. Sulfamethoxazole and triclosan were readily photodegraded with half-lives of 5.8 and 1.8 h, respectively, whilst the others were relatively resistant towards sunlight irradiation...
June 29, 2017: Chemosphere
https://www.readbyqxmd.com/read/28698728/association-of-25-hydroxyvitamin-d-deficiency-in-pediatric-epileptic-patients
#17
Jaydip Ray Chaudhuri, Kandadai Rukmini Mridula, Chakrala Rathnakishore, Banda Balaraju, Vcs Srinivasarao Bandaru
OBJECTIVE: Epilepsy is a chronic neurological disorder requiring long-term therapy using antiepileptic medications. Reports have incriminated long-term antiepileptic drugs use in deficiency of vitamin D and bone diseases in all age groups. We aimed to investigate the association between serum 25-hydroxyvitamin D levels and pediatric epilepsy in Indian patients. MATERIALS & METHODS: We prospectively recruited 100 pediatric epilepsy patients, on monotherapy for minimum one-year duration, and 50 age and sex matched controls...
2017: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/28698724/hla-b-1502-in-iranian-children-with-anticonvulsant-drugs-induced-skin-reactions
#18
Seyed Hasan Tonekaboni, Narjes Jafari, Mahboubeh Mansouri, Sayena Jabbehdari, Rahil Eftekhari, Zahra Chavoshzadeh, Fatemeh Abdollah Gorji, Mehrnaz Mesdaghi
OBJECTIVE: Anticonvulsant drugs can cause various forms of skin drug reactions, ranging from exanthema to severe blistering reactions. An association between HLA-B*1502 allele and severe skin reactions have been reported. MATERIALS & METHODS: Fifteen patients with severe skin reactions following treatment with anticonvulsant drugs (Carbamazepine, lamotrigine, phenobarbital, primidone) and 15 controls (age-matched epileptic patients taking similar anticonvulsants without drug eruption) were included...
2017: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/28697991/carbamazepine-effects-on-pain-management-and-serum-il-6-il-10-evaluation-in-addicted-patients-undergoing-surgery
#19
Alireza Salimi, Masoumeh Sabetkasaei, Hanna Raisi, Farzaneh Labibi, Haleh Ameli, Yalda Khazaei-Poul, Kamran Mottaghi, Farhad Safari, Ali Nazem-Bokaei, Seyed-Amir Mohajerani, Malek Zarei, Taraneh Moini-Zanjani
Postoperative pain control remains an important issue in the field of surgery. Assessing and managing patients with acute pain who are addicted to opioids are often challenging. It has been shown that, addicted patients are less tolerant to pain. There is limited evidence to guide the management of acute pain in these patients. Here we studied the effect of preemptive use of carbamazepine on pain behavior and serum IL-6, IL-10 levels in the addicted patients. 90 male patients (25-45 years, BMI 20-27), were divided into 3 group of 30 patients: 1- control, 2- addicted, 3- addicted patients receiving carbamazepine 400mg before surgery...
July 8, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28693900/biodegradation-of-pharmaceuticals-and-endocrine-disruptors-with-oxygen-nitrate-manganese-iv-iron-iii-and-sulfate-as-electron-acceptors
#20
Natalie Schmidt, Declan Page, Andreas Tiehm
Biodegradation of pharmaceuticals and endocrine disrupting compounds was examined in long term batch experiments for a period of two and a half years to obtain more insight into the effects of redox conditions. A mix including lipid lowering agents (e.g. clofibric acid, gemfibrozil), analgesics (e.g. diclofenac, naproxen), beta blockers (e.g. atenolol, propranolol), X-ray contrast media (e.g. diatrizoic acid, iomeprol) as well as the antiepileptic carbamazepine and endocrine disruptors (e.g. bisphenol A, 17α-ethinylestradiol) was analyzed in batch tests in the presence of oxygen, nitrate, manganese (IV), iron (III), and sulfate...
June 27, 2017: Journal of Contaminant Hydrology
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