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https://www.readbyqxmd.com/read/29243813/antiepileptic-drug-monotherapy-for-epilepsy-a-network-meta-analysis-of-individual-participant-data
#1
REVIEW
Sarah J Nevitt, Maria Sudell, Jennifer Weston, Catrin Tudur Smith, Anthony G Marson
BACKGROUND: Epilepsy is a common neurological condition with a worldwide prevalence of around 1%. Approximately 60% to 70% of people with epilepsy will achieve a longer-term remission from seizures, and most achieve that remission shortly after starting antiepileptic drug treatment. Most people with epilepsy are treated with a single antiepileptic drug (monotherapy) and current guidelines from the National Institute for Health and Care Excellence (NICE) in the United Kingdom for adults and children recommend carbamazepine or lamotrigine as first-line treatment for partial onset seizures and sodium valproate for generalised onset seizures; however a range of other antiepileptic drug (AED) treatments are available, and evidence is needed regarding their comparative effectiveness in order to inform treatment choices...
December 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29242946/clinical-viral-and-genetic-characteristics-of-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-in-shanghai-china
#2
Xiaojin Wu, Fanping Yang, Shengan Chen, Hao Xiong, Qinyuan Zhu, Xudong Gao, Qinghe Xing, Xiaoqun Luo
DRESS is one of the most severe drug reactions. The aim of this retrospective study was to summarize the clinical presentation, genetic predisposition and prognostic factors of DRESS. A total of 52 patients with DRESS, who were inpatients at a medical referral centre in Shanghai, China, from January 2011 to December 2016, were analysed retrospectively. All the patients had skin eruption, 83% had liver involvement, and ≤10% had other organ involvement. Average cost of hospitalization was $5,511±3,050. The 3 most common causative agents were allopurinol (18/52; 35%), salazosulphapyridine (11/52; 21%) and carbamazepine (5/52; 10%)...
December 15, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/29238897/carbamazepine-associated-hypersensitivity-colitis
#3
Wa'el Tuqan, Sarah Lee, Joshua Hanson, Denis McCarthy
No abstract text is available yet for this article.
December 14, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29232752/simultaneous-determination-of-rosuvastatin-rosuvastatin-5%C3%A2-s-lactone-and-n-desmethyl-rosuvastatin-in-human-plasma-by-uplc-ms-ms-and-its-application-to-clinical-study
#4
Xue Bai, Xi-Pei Wang, Guo-Dong He, Bin Zhang, Min Huang, Jia-Li Li, Shi-Long Zhong
Objective A rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) assay was developed and validated for the simultaneous quantification of rosuvastatin (RST), rosuvastatin-5 S-lactone (RSTL), and N-desmethyl rosuvastatin (DM-RST) in human plasma. Methods Sample was prepared by liquid-liquid extraction with ethyl acetate from 100 μL acidulated buffered plasma. Then analytes were chromatographically separated using an Acquity UPLC HSS T3 column (3.0 mm×100 mm, 1...
December 12, 2017: Drug Research
https://www.readbyqxmd.com/read/29232050/affinity-extraction-of-emerging-contaminants-from-water-based-on-bovine-serum-albumin-as-a-binding-agent
#5
Efthimia Papastavros, Rachael A Remmers, Daniel D Snow, David A Cassada, David S Hage
Affinity sorbents using bovine serum albumin as a binding agent were developed and tested for the extraction of environmental contaminants from water. Computer simulations based on a countercurrent distribution model were also used to study the behavior of these sorbents. Several model drugs, pesticides and hormones of interest as emerging contaminants were considered in this work, with carbamazepine being used as a representative analyte when coupling the albumin column on-line with liquid chromatography and tandem mass spectrometry...
December 12, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29231320/-comparative-observation-of-the-efficacy-on-facial-spasm-among-different-therapies
#6
Lili Zhang, Lei Zhao, Ying Bai
OBJECTIVE: To compare the differences in the clinical efficacy on facial spasm among auricular acupuncture, acupuncture and western medication. METHODS: Ninety cases of facial spasm were randomized into an auricular acupuncture group, an acupuncture group and a western medication group, 30 cases in each one. In the auricular acupuncture group, yan (LO5), shenmen (TF4), xin (CO15), gan (CO12), pi (CO13), pizhixia (AT4), chuiqian (LO4), and zhen (AT3) were selected...
January 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29227872/low-levels-of-iron-enhance-uv-h2o2-efficiency-at-neutral-ph
#7
Sydney L Ulliman, Garrett McKay, Fernando L Rosario-Ortiz, Karl G Linden
While the presence of iron is generally not seen as favorable for UV-based treatment systems due to lamp fouling and decreased UV transmittance, we show that low levels of iron can lead to improvements in the abatement of chemicals in the UV-hydrogen peroxide advanced oxidation process. The oxidation potential of an iron-assisted UV/H2O2 (UV254 + H2O2 + iron) process was evaluated at neutral pH using iron levels below USEPA secondary drinking water standards (<0.3 mg/L). Para-chlorobenzoic acid (pCBA) was used as a hydroxyl radical (HO) probe to quantify HO steady state concentrations...
November 21, 2017: Water Research
https://www.readbyqxmd.com/read/29227273/-poisoning-by-psychopharmacological-drugs-in-azerbaijan-the-results-of-8-year-prospective-observation
#8
I Afandiyev, V Azizov
Acute poisoning of chemical etiology is a significant global public health problem. The aim of this study was the analysis of the toxicoepidemiological structure of psychopharmacological drugs poisoning in Azerbaijan. We collected and analyzed the data on all cases of acute poisoning by psychopharmacological drugs (codes of categories T42/T43 ICD-10) undergoing inpatient treatment at the Center of Clinical Toxicology in Baku, Azerbaijan in 2009-2016. The total number of patients with acute intoxication by psychopharmacological drugs was 3,413, which was 48...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29226308/hla-b-1502-haplotype-screening-prior-to-carbamazepine-administration-in-individuals-of-south-east-asian-ancestry-nears-cost-effectiveness-in-preventing-severe-cutaneous-adverse-drug-reactions
#9
Emma Kim, Ian McCrossin, John W Frew
No abstract text is available yet for this article.
December 11, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/29223892/liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-determination-of-six-pharmaceuticals-in-vegetal-biota-uptake-study-in-lavandula-dentata
#10
Sofía Barreales-Suárez, Manuel Callejón-Mochón, Stéphane Azoulay, Miguel Ángel Bello-López, Rut Fernández-Torres
A procedure based on microwave assisted extraction for the determination of 6 pharmaceuticals in samples of Lavandula dentata, Salicornia ramosissima and Juncus sp. by liquid chromatography-quadrupole time of flight mass spectrometry (LC-QTOF/MS) was optimized and validated. Best results were obtained using microwave assisted extraction of 1.0g of homogeneous lyophilized samples and 5mL of a mixture ACN:H2O (1:1 v/v) as extracting solvent. Analytical recoveries ranged from 60 to 107% with relative standard deviation (RSD) lower than 15%...
December 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29221654/numerical-simulation-of-hot-melt-extrusion-processes-for-amorphous-solid-dispersions-using-model-based-melt-viscosity
#11
Esther S Bochmann, Kristina E Steffens, Andreas Gryczke, Karl G Wagner
Simulation of HME processes is a valuable tool for increased process understanding and ease of scale-up. However, the experimental determination of all required input parameters is tedious, namely the melt rheology of the amorphous solid dispersion (ASD) in question. Hence, a procedure to simplify the application of hot-melt extrusion (HME) simulation for forming amorphous solid dispersions (ASD) is presented. The commercial 1D simulation software Ludovic® was used to conduct (i) simulations using a full experimental data set of all input variables including melt rheology and (ii) simulations using model-based melt viscosity data based on the ASDs glass transition and the physical properties of polymeric matrix only...
December 5, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29215383/mood-stabilizing-anticonvulsants-spina-bifida-and-folate-supplementation-commentary
#12
Neil Patel, Adele C Viguera, Ross J Baldessarini
PURPOSE/BACKGROUND: High risks of neural tube defects and other teratogenic effects are associated with exposure in early pregnancy to some anticonvulsants, including in women with bipolar disorder. METHODS/PROCEDURES: Based on a semistructured review of recent literature, we summarized findings pertaining to this topic. FINDINGS/RESULTS: Valproate and carbamazepine are commonly used empirically (off-label) for putative long-term mood-stabilizing effects...
December 6, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29210977/influence-of-comedication-on-levetiracetam-pharmacokinetics
#13
Azucena Aldaz, Natalia Alzueta, César Viteri
BACKGROUND: Evaluate the effect of concomitant antiepileptic therapy on levetiracetam (LEV) pharmacokinetics. METHODS: A 6-year retrospective observational study. Patients were grouped according to the antiepileptic drug (AED) used as concomitant medication: Group A, LEV in monotherapy; Group B, LEV + enzyme-inducing antiepileptic drugs (EIAEDs) and Group C, LEV + non-enzyme-inducing antiepileptic drugs (NEIAEDs). Apparent oral LEV clearance (LEV CL/F) and basal serum LEV concentrations (LEV C0) were compared among the different groups by analysis of variance (ANOVA)...
November 23, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/29209976/do-cemeteries-emit-drugs-a-case-study-from-southern-germany
#14
Sabine Fiedler, Torsten Dame, Matthias Graw
The risk of earth burials for the environment and public health is a matter of controversial debate. The aim of the present study is to characterise the drainage of cemeteries with regard to the concentration of a number of pharmaceuticals and to the soil's hydrochemical properties, and to discuss these data in comparison with data obtained for surface waters located upstream of the cemeteries. Of the 12 drainage samples analysed using LC-ESI-MS/MS, seven contained carbamazepine (< 225 ng l-1), five contained hydrochlorothiazide, one contained metoprolol (23 ng l-1) and one contained traces of ibuprofen...
December 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29207763/carbamazepine-induced-thrombocytopenia
#15
Ruhi Kumar, Sridhar Chivukula, Goutham Reddy Katukuri, U K Chandrasekhar, K N Shivashankar
Antiepileptic Drugs (AEDs) are commonly associated with haematological disorders, including anaemia, thrombocytopenia, neutropenia and even bone marrow failure. Fatal disorders like aplastic anaemia are uncommon. On exploring through the literature, older AEDs are more associated with haematological alterations than newer AEDs, and careful monitoring is warranted especially with phenytoin, carbamazepine and valproate. The exact cause of these alterations is not established, though immune mechanisms and pharmacology of individual drugs are the proposed mechanisms, a further research along this path is underway...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29203420/compound-action-potential-inhibition-produced-by-various-antidepressants-in-the-frog-sciatic-nerve
#16
Ryo Hirao, Tsugumi Fujita, Aiko Sakai, Eiichi Kumamoto
Although an inhibition of action potential conduction in nerve fibers possibly contributes to at least a part of antinociception produced by analgesics and the adjuvants, it has not been fully examined yet how the conduction inhibition differs in extent among their drugs. We investigated the effects of various antidepressants used as analgesic adjuvants on compound action potentials (CAPs) recorded from the frog sciatic nerve by using the air-gap method. The results were compared with those of the other adjuvants that were reported previously...
December 1, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29202707/functional-snp-allele-discovery-fsnpd-an-approach-to-find-highly-penetrant-environmental-triggered-genotypes-underlying-complex-human-phenotypes
#17
Kaitlin Stouffer, Michael Nahorski, Pablo Moreno, Nivedita Sarveswaran, David Menon, Michael Lee, C Geoffrey Woods
BACKGROUND: Significant human diseases/phenotypes exist which require both an environmental trigger event and a genetic predisposition before the disease/phenotype emerges, e.g. Carbamazepine with the rare SNP allele of rs3909184 causing Stevens Johnson syndrome, and aminoglycosides with rs267606617 causing sensory neural deafness. The underlying genotypes are fully penetrant only when the correct environmental trigger(s) occur, otherwise they are silent and harmless. Such diseases/phenotypes will not appear to have a Mendelian inheritance pattern, unless the environmental trigger is very common (>50% per lifetime)...
December 4, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29202555/drug-induced-by-systemic-lupus-erythematosus-presenting-as-recurrent-pericardial-effusion-after-mitral-valve-repair
#18
Aghigh Haydari, Feridoun Sabzi, Samsam Dabiri, Alireza Poormotaabed
We report a patient presented with recurrent pericardial effusion caused by drug-induced systemic lupus Erythematosus (SLE) following mitral valve repair. The surgery was complicated by hemiparesis and convulsion in early postoperative period. The patient had been received carbamazepine for a paroxysmal seizure that occurred following mitral valve repair. The post operative computed tomography showed embolic stroke and its sequel (seizure) that treated with carbamazepine. In the 3rd month of follow-up, however, hemiparesis recovered by physiotherapy but carbamazepine was not discontinued as by request of neurologist...
September 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29202420/detecting-sulfamethoxazole-and-carbamazepine-in-groundwater-is-elisa-a-reliable-screening-tool
#19
Aliesha L Krall, Sarah M Elliott, Melinda L Erickson, Byron A Adams
In recent years, numerous studies have reported the prevalence of organic micropollutants in natural waters. There is an increasing interest in assessing the occurrence and transport of these contaminants in groundwater because a large number of people in the United States rely on groundwater for their drinking water. However, commonly used mass-spectrometry-based analytical methods are expensive and time-consuming. The enzyme-linked immunosorbent assay (ELISA) method offers an inexpensive analytical alternative that provides semi-quantitative results in a relatively quick timeframe...
December 1, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29201285/familial-trigeminal-neuralgia-treated-with-stereotactic-radiosurgery-a-case-report-and-literature-review
#20
Ryan A Denu, Stephen A Rosenberg, Steven P Howard
Background: Trigeminal neuralgia (TN) is a chronic pain condition characterized by brief episodes of lancinating pain in one or more distributions of the trigeminal nerve. Episodes of pain secondary to TN are triggered by certain stimuli, such as chewing, shaving, or touching the face. Although a common cause of TN is compression of the trigeminal nerve root entry zone by an artery or vein, many cases of TN are idiopathic. However, there have been limited reports in the literature of familial TN...
June 2017: Journal of Radiation Oncology
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