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https://www.readbyqxmd.com/read/28079158/aryl-hydrocarbon-receptor-ahr-dependent-regulation-of-pulmonary-mirna-by-chronic-cigarette-smoke-exposure
#1
Sarah Rogers, Angela Rico de Souza, Michela Zago, Matthew Iu, Necola Guerrina, Alvin Gomez, Jason Matthews, Carolyn J Baglole
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor historically known for its toxic responses to man-made pollutants such as dioxin. More recently, the AhR has emerged as a suppressor of inflammation, oxidative stress and apoptosis from cigarette smoke by mechanisms that may involve the regulation of microRNA. However, little is known about the AhR regulation of miRNA expression in the lung in response to inhaled toxicants. Therefore, we exposed Ahr(-/-) and Ahr(+/-) mice to cigarette smoke for 4 weeks and evaluated lung miRNA expression by PCR array...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28076456/propofol-inhibits-lung-cancer-cell-viability-and-induces-cell-apoptosis-by-upregulating-microrna-486-expression
#2
N Yang, Y Liang, P Yang, T Yang, L Jiang
Propofol is a frequently used intravenous anesthetic agent. Recent studies show that propofol exerts a number of non-anesthetic effects. The present study aimed to investigate the effects of propofol on lung cancer cell lines H1299 and H1792 and functional role of microRNA (miR)-486 in these effects. H1299 and/or H1792 cells were treated with or without propofol and transfected or not with miR-486 inhibitor, and then cell viability and apoptosis were analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and flow cytometry...
January 5, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28075475/mir-134-suppresses-the-migration-and-invasion-of-non%C3%A2-small-cell-lung-cancer-by-targeting-itgb1
#3
Qin Qin, Furong Wei, Jianbo Zhang, Baosheng Li
Most cancer-related deaths are caused by the development of metastatic disease. Thus, investigation of the underlying mechanisms of metastasis is urgent to design more effective targeted drugs and to treat metastatic disease more effectively. MicroRNAs (miRNAs) have emerged as potential targets for cancer treatment. In the present study, we aimed to identify the roles of miR-134 in non-small cell lung cancer (NSCLC) cell migration and invasion. We demonstrated that overexpression of miR-134 inhibited migration and invasion of A549 and H1299 cells...
January 3, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28075452/a-novel-pathway-in-nsclc-cells-mir%C3%A2-191-targeting-nfia-is-induced-by-chronic-hypoxia-and-promotes-cell-proliferation-and-migration
#4
Jia Zhao, Cheng-Rui Qiao, Zheng Ding, Yin-Liang Sheng, Xiang-Nan Li, Yang Yang, Deng-Yan Zhu, Chun-Yang Zhang, Dong-Lei Liu, Kai Wu, Song Zhao
MicroRNAs (miRs) have emerged as being important in cancer biology. miR‑191 is a conserved miRNA, which has been investigated in detail and is reported to be induced by hypoxia-inducible factor (HIF)‑1α and has an contributory action in the progression of breast, hepatic and pancreatic cancer. However, the effects of miR‑191 in the progression of lung cancer are a subject of debate. In the present study, it was found that the expression of miR-191 was significantly upregulated in non‑small cell lung cancer (NSCLC) cells in patients in vivo...
January 4, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28073028/multiplexed-detection-of-lung-cancer-biomarkers-in-patients-serum-with-cmos-compatible-silicon-nanowire-arrays
#5
Anran Gao, Xun Yang, Jing Tong, Lin Zhou, Yuelin Wang, Jianlong Zhao, Hongju Mao, Tie Li
In this work, a real-time assay for highly sensitive, label-free, multiplexed electrical detection of lung cancer biomarkers was developed by using silicon nanowire field-effect (SiNW-FET) devices. Highly responsive SiNW arrays were fabricated using a CMOS-compatible anisotropic self-stop etching technique with mass reproducibility and low cost character. The SiNW nanosensor was integrated with PDMS microfluidic device, which allows rapid analyte delivery, makes the analysis to be conducted using exceedingly small samples and enables potential multiplexed detection...
January 3, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28070693/micrornas-expression-as-novel-genetic-biomarker-for-early-prediction-and-continuous-monitoring-in-pulmonary-cancer
#6
REVIEW
Razvan Nitu, Alexandru Florin Rogobete, Fuat Gundogdu, Sonia Tanasescu, Ovidiu Boruga, Adriana Sas, Sonia Elena Popovici, Delia Hutanu, Ciprian Pilut, Cristian Andrei Sarau, Adrian Constantin Candea, Adrian Tudor Stan, Liviu Marius Moise
One of the main causes of death in the world is lung cancer. According to the World Health Organization, the annual incidence of lung cancer increases significantly. Moreover, lung cancer accounts for one of the highest mortality rates, mainly due to late detection. Numerous studies have been conducted in order to identify new biomarkers for early diagnosis and for monitoring and evaluation of lung cancer stages. An ideal biomarker candidate is represented by the analysis of microRNAs expression. In this paper, we want to summarize microRNAs expressions in lung cancer...
January 9, 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/28067164/curcumin-and-lung-cancer-the-role-of-micrornas
#7
Diana Lelli, Claudio Pedone, Muhammed Majeed, Amirhosssein Sahebkar
BACKGROUND: Lung cancer is one of the most common types of cancer worldwide and is characterized by a poor prognosis, related both to late diagnosis and lack of effective treatments. In the last years, microRNAs (miRNAs) have been demonstrated to have an important role in tumor microenvironment and immune regulation. These RNAs can be categorized into tumor-suppressor genes, such as let-7 family and miR-34, and oncogenes such as miR-221 and miR-222. Curcumin is a bioactive polyphenol that is documented to have promising anti-cancer activity, and to be well tolerated in humans...
January 9, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28063900/smoker-extracellular-vesicles-influence-status-of-human-bronchial-epithelial-cells
#8
Amélie Héliot, Yann Landkocz, Françoise Roy Saint-Georges, Pierre Gosset, Sylvain Billet, Pirouz Shirali, Dominique Courcot, Perrine J Martin
Cigarette smoking is a habit that has spread all over the world and is a significant risk factor for many diseases including cardiovascular disease, chronic obstructive pulmonary disease (COPD), asthma and lung cancer. Evaluation and understanding of tobacco health effects are of major interest worldwide and answer to important societal concerns. Identification of new biomarkers of exposure to tobacco smoke potentially implicated in COPD or lung carcinogenesis would allow a better observation of tobacco exposed population, thanks to screening establishment at reversible stages of pathological processes...
December 30, 2016: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28057758/down-regulation-of-claudin-2-expression-and-proliferation-by-epigenetic-inhibitors-in-human-lung-adenocarcinoma-a549-cells
#9
Asami Hichino, Miki Okamoto, Saeko Taga, Risa Akizuki, Satoshi Endo, Toshiyuki Matsunaga, Akira Ikari
Claudin-2 is highly expressed in lung adenocarcinoma tissues and increases proliferation in adenocarcinoma cells. The chemicals which reduce claudin-2 expression may have anti-cancer effect, but such therapeutic medicines have not been developed. We found that azacitidine (AZA), a DNA methylation inhibitor, and trichostatin A (TSA) and sodium butyrate (NaB), histone deacetylase (HDAC) inhibitors, decrease claudin-2 levels. The effect of AZA was mediated by the inhibition of phosphorylated Akt and NFκB. LY-294002, an inhibitor of phosphatidyl inositol-3 kinase (PI3K), and BAY 11-7082, an NF-κB inhibitor, decreased claudin-2 levels...
January 5, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28055956/circulating-exosomal-micrornas-as-prognostic-biomarkers-for-non-small-cell-lung-cancer
#10
Qingyun Liu, Zubin Yu, Shuai Yuan, Weijia Xie, Chengying Li, Zeyao Hu, Ying Xiang, Na Wu, Long Wu, Li Bai, Yafei Li
Exosomal miRNAs are proposed as excellent candidate biomarkers for clinical applications. However, little is known about their potential roles as prognostic biomarkers in lung cancer. In this study, we explored the prognostic value of plasma exosomal microRNAs (miRNAs) for non-small-cell lung cancer (NSCLC). Using a quantitative polymerase chain reaction (qPCR) array panel, we analyzed 84 plasma exosomal miRNAs in 10 lung adenocarcinoma patients and 10 matched healthy controls. The qPCR array showed 30 aberrantly expressed exosomal miRNAs...
December 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/28054302/microrna-761-induces-aggressive-phenotypes-in-triple-negative-breast-cancer-cells-by-repressing-trim29-expression
#11
Guang-Cheng Guo, Jia-Xiang Wang, Ming-Li Han, Lian-Ping Zhang, Lin Li
PURPOSE: Despite advances that have been made in systemic chemotherapy, the prognosis of advanced triple-negative breast cancer (TNBC) patients is still poor. The identification of key factors governing TNBC development is considered imperative for the development of novel effective therapeutic approaches. Previously, it has been reported that microRNA (miR)-761 may act as either a tumor suppressor or as an oncogene in different types of cancer. Here, we aimed at assessing the biological role of this miRNA in TNBC...
January 4, 2017: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/28047826/we-ab-207b-02-a-bayesian-network-approach-for-joint-prediction-of-tumor-control-and-radiation-pneumonitis-rp-in-non-small-cell-lung-cancer-nsclc
#12
Y Luo, D McShan, M Matuszak, S Hobson, S Jolly, R Ten Haken, I El Naqa
PURPOSE: NSCLC radiotherapy treatment is a trade-off between controlling the tumor while limiting radiation-induced toxicities. Here we identify hierarchical biophysical relationships that could simultaneously influence both local control (LC) and RP by using an integrated Bayesian Networks (BN) approach. METHODS: We studied 79 NSCLC patients treated on prospective protocol with 56 cases of LC and 21 events of RP. Beyond dosimetric information, each patient had 193 features including 12 clinical factors, 60 circulating blood cytokines before and during radiotherapy, 62 microRNAs, and 59 single-nucleotide polymorphisms (SNPs)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042945/minicircle-orip-mir-31-as-a-novel-ebna1-specific-mirna-therapy-approach-for-nasopharyngeal-carcinoma
#13
Jiang-Xue Wu, Xin Tan, Jiaxin Lin, Luping Yuan, Jiemin Chen, Lin Qiu, Wen-Lin Huang
MicroRNAs (miRNAs) are important post-transcriptional regulators that control cancer development and progression. However, the application of miRNA therapy in cancer has been hampered by a lack of an efficient and targeted delivery system. In our previous studies, an oriP promoter-based minicircle system successfully mediated targeted foreign gene expression in EBNA1-positive nasopharyngeal carcinoma (NPC). However, it remains to be evaluated whether this system can be applied for tumor miRNA therapy. miR-31-5p, a tumor suppressive miRNA involved in the tumorigenesis of EBV-positive NPC, was selected as the therapeutic miRNA to be transferred...
January 2, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28035947/non-coding-rnas-in-lung-cancer-contribution-of-bioinformatics-analysis-to-the-development-of-non-invasive-diagnostic-tools
#14
REVIEW
Meik Kunz, Beat Wolf, Harald Schulze, David Atlan, Thorsten Walles, Heike Walles, Thomas Dandekar
Lung cancer is currently the leading cause of cancer related mortality due to late diagnosis and limited treatment intervention. Non-coding RNAs are not translated into proteins and have emerged as fundamental regulators of gene expression. Recent studies reported that microRNAs and long non-coding RNAs are involved in lung cancer development and progression. Moreover, they appear as new promising non-invasive biomarkers for early lung cancer diagnosis. Here, we highlight their potential as biomarker in lung cancer and present how bioinformatics can contribute to the development of non-invasive diagnostic tools...
December 26, 2016: Genes
https://www.readbyqxmd.com/read/28035073/microrna-expression-profiles-and-clinicopathological-implications-in-lung-adenocarcinoma-according-to-egfr-kras-and-alk-status
#15
Hyojin Kim, Jeong Mi Yang, Yan Jin, Sanghoon Jheon, Kwhanmien Kim, Choon Taek Lee, Jin-Haeng Chung, Jin Ho Paik
Lung adenocarcinoma has distinctive clinicopathological features that are related to specific genetic alterations, including EGFR and KRAS mutations and ALK rearrangement. MicroRNAs are small non-coding RNAs that post-transcriptionally regulate many important biological processes and influence cancer phenotypes. This study retrospectively investigated microRNA expression profiles, and their clinicopathological implications, in lung adenocarcinoma according to genetic status (EGFR, KRAS, ALK, and triple negative)...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28026121/circulating-exosomal-microrna-96-promotes-cell-proliferation-migration-and-drug-resistance-by-targeting-lmo7
#16
Hao Wu, Jingcheng Zhou, Shanshan Mei, Da Wu, Zhimin Mu, Baokun Chen, Yuancai Xie, Yiwang Ye, Jixian Liu
Detection and treatment of lung cancer still remain a clinical challenge. This study aims to validate exosomal microRNA-96 (miR-96) as a serum biomarker for lung cancer and understand the underlying mechanism in lung cancer progression. MiR-96 expressions in normal and lung cancer patients were characterized by qPCR analysis. Changes in cell viability, migration and cisplatin resistance were monitored after incubation with isolated miR-96-containing exosomes, anti-miR-96 and anti-miR negative control (anti-miR-NC) transfections...
December 27, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28025999/mir-200a-3p-promotes-the-proliferation-of-human-esophageal-cancer-cells-by-post-transcriptionally-regulating-cytoplasmic-collapsin-response-mediator-protein-1
#17
Yanzi Zang, Yong Tai, Baoluo Wan, Xiaodong Jia
The dysregulation of cytoplasmic collapsin response mediator protein 1 (CRMP1) has been reported in lung cancer, medulloblastoma and esophageal cancer. However, the role of CRMP1 and its regulatory mechanisms in esophageal cancer remain unclear. In this study, we demonstrated that CRMP1 expression was downregulated in esophageal cancer tissues and that there were differences in its expression levels in different esophageal cancer cell lines. We found that CRMP1 overexpression inhibited the proliferation of esophageal cancer cells, whereas the silencing of CRMP1 promoted cell proliferation...
November 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28004116/mir-592-functions-as-a-tumor-suppressor-in-human-non-small-cell-lung-cancer-by-targeting-sox9
#18
Zhihong Li, Bai Li, Liang Niu, Liang Ge
A growing body of evidence suggests that microRNA-592 (miR-592) may be involved in the initiation and progression of cancer by targeting various molecules in several human cancers. However, the function and underlying molecular mechanism of miR-592 in non-small cell lung cancer (NSCLC) remains unclear. In the present study, we found that miR-592 was significantly downregulated in NSCLC cell lines and tissues by real-time quantitative RT-PCR (qRT-PCR), and that lower miR-592 expression was negatively associated with advanced tumor/nodes/metastasis (TNM) classification stages (P<0...
January 2017: Oncology Reports
https://www.readbyqxmd.com/read/28002496/exosomal-mirs-in-lung-cancer-a-mathematical-model
#19
Xiulan Lai, Avner Friedman
Lung cancer, primarily non-small-cell lung cancer (NSCLC), is the leading cause of cancer deaths in the United States and worldwide. While early detection significantly improves five-year survival, there are no reliable diagnostic tools for early detection. Several exosomal microRNAs (miRs) are overexpressed in NSCLC, and have been suggested as potential biomarkers for early detection. The present paper develops a mathematical model for early stage of NSCLC with emphasis on the role of the three highest overexpressed miRs, namely miR-21, miR-205 and miR-155...
2016: PloS One
https://www.readbyqxmd.com/read/28000891/expression-of-mir%C3%A2-26a-exhibits-a-negative-correlation-with-hmga1-and-regulates-cancer-progression-by-targeting-hmga1-in-lung-adenocarcinoma-cells
#20
Noboru Sekimoto, Ayako Suzuki, Yutaka Suzuki, Sumio Sugano
Lung cancer is the most common cause of cancer‑associated mortality worldwide, and the number of cases is increasing annually. Several studies have shown that microRNAs (miRNAs) control proliferation, differentiation, and apoptosis in various cell types, and increasing evidence indicates the presence of aberrant miRNA expression profiles and unique miRNA signaling pathways in several types of cancer. The present study aimed to identify miRNAs, which correlated specifically with the progression of lung cancer through the analysis of 57,100 transcripts and 1,341 small RNA expression profiles in 26 lung adenocarcinoma cell lines using next‑generation sequencing...
December 15, 2016: Molecular Medicine Reports
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