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https://www.readbyqxmd.com/read/28109180/the-intrauterine-renin-angiotensin-system-sex-specific-effects-on-the-prevalence-of-spontaneous-preterm-birth
#1
Kirsty G Pringle, Tamas Zakar, Eugenie R Lumbers
Preterm birth (PTB) is the single largest cause of death in infants and young children. The rate of PTB is significantly higher in male infants, particularly those that are born very preterm. Here we present evidence to suggest that the decidual renin-angiotensin system may play a role in inhibiting inflammation and maintaining the integrity of the fetal membranes during pregnancy, and that sex-specific alterations in the intrauterine RAS could contribute to the increased risk of PTB in male babies. Women carrying female fetuses have high levels of expression of decidual prorenin at term...
January 21, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28109006/attitudes-towards-non-invasive-prenatal-diagnosis-among-obstetricians-in-pakistan-a-developing-islamic-country
#2
Shenaz Ahmed, Hussain Jafri, Yasmin Rashid, Gerald Mason, Yasmin Ehsan, Mushtaq Ahmed
OBJECTIVES: Stakeholders' views are essential for informing implementation strategies for non-invasive prenatal testing (NIPT). Little is known about such views in developing countries. We explored attitudes toward NIPT among obstetricians in Pakistan, a developing Islamic country. METHODS: A 35-item questionnaire was distributed and collected at eight events (a national conference and seven workshops in five cities) for obstetric professionals on advances in fetal medicine...
January 20, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28109003/eradication-of-hcv-and-non-liver-related-non-aids-related-events-in-hiv-hcv-coinfection
#3
Juan Berenguer, Elena Rodríguez-Castellano, Ana Carrero, Miguel A Von Wichmann, Marta Montero, María J Galindo, Josep Mallolas, Manuel Crespo, María J Téllez, Carmen Quereda, José Sanz, Carlos Barros, Cristina Tural, Ignacio Santos, Federico Pulido, Josep M Guardiola, Rafael Rubio, Enrique Ortega, María L Montes, Juan J Jusdado, Gabriel Gaspar, Herminia Esteban, José M Bellón, Juan González-García
: We assessed non-liver-related non-AIDS-related (NLR-NAR) events and mortality in a cohort of HIV/HCV-coinfected patients treated with interferon and ribavirin between 2000 and 2008. The censoring date was May 31, 2014. Cox regression analysis was performed to assess the adjusted hazard rate (HR) of overall death in responders and non-responders. Fine and Gray regression analysis was conducted to determine the adjusted sub-hazard rate (sHR) of NLR deaths and NLR-NAR events considering death as the competing risk...
January 21, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28108922/association-between-heavy-metal-and-metalloid-levels-in-topsoil-and-cancer-mortality-in-spain
#4
Olivier Núñez, Pablo Fernández-Navarro, Iván Martín-Méndez, Alejandro Bel-Lan, Juan F Locutura Rupérez, Gonzalo López-Abente
Spatio-temporal cancer mortality studies in Spain have revealed patterns for some tumours which display a distribution that is similar across the sexes and persists over time. Such characteristics would be common to tumours that shared risk factors, including the geochemical composition of the soil. The aim of this study was to assess the possible association between heavy metal and metalloid levels in topsoil (upper soil horizon) and cancer mortality in mainland Spain. Ecological cancer mortality study at a municipal level, covering 861,440 cancer deaths (27 different tumour locations) in 7917 Spanish mainland towns, from 1999 to 2008...
January 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28108855/causes-of-poor-outcome-in-patients-admitted-with-good-grade-subarachnoid-haemorrhage
#5
Vladimír Beneš, Lubomír Jurák, Radim Brabec, Nina Nechanická, Miroslav Šercl, Ladislav Endrych, Pavel Buchvald, Petr Suchomel
BACKGROUND: Surgical risk in patients with unruptured aneurysms is well known. The relative impact of surgery and natural history of subarachnoid haemorrhage (SAH) on patients in good clinical condition (World Federation of Neurological Surgeons [WFNS] grades 1 and 2) is less well quantified. The aim of this study was to determine causes of poor outcome in patients admitted in good grade SAH. METHODS: A retrospective study of prospectively collected data among WFNS-1 and -2 patients: demographics, SAH and aneurysm-related data, surgical complications and outcome as assesed by the Glasgow Outcome Scale (GOS)...
January 20, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28108702/is-rectal-douching-and-sharing-douching-equipment-associated-with-anorectal-chlamydia-and-gonorrhoea-a-cross-sectional-study-among-men-who-have-sex-with-men
#6
Rca Achterbergh, J J van der Helm, W van den Boom, T Heijman, I G Stolte, M S van Rooijen, Hjc de Vries
INTRODUCTION: Men who have sex with men (MSM) are at high risk for anorectal chlamydia and gonorrhoea infections. Many MSM use rectal douches in preparation for sex, which might break down the mucosal barrier function and facilitate the acquisition of STI. We determined whether rectal douching or sharing douching equipment was associated with anorectal chlamydia and gonorrhoea. METHODS: In a cross-sectional study among 994 MSM attending the STI outpatient clinic of Amsterdam between February and April 2011, data were collected on rectal douching, sexual behaviour and STI...
January 20, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28108639/prevalence-of-epilepsy-seizures-as-a-comorbidity-of-neurologic-disorders-in-nursing-homes
#7
Angela K Birnbaum, Ilo E Leppik, Kenneth Svensden, Lynn E Eberly
OBJECTIVE: To determine the prevalence of epilepsy/seizure (epi/sz) comorbid with other neurologic disorders in elderly nursing home residents and to examine demographic and regional variability and associations with clinical characteristics. METHODS: We studied 5 cross-sectional cohorts of all residents in any Medicare/Medicaid-certified nursing home in the United States on July 15 of each year from 2003 to 2007. Epi/sz was identified by ICD-9 codes (345.xx or 780...
January 20, 2017: Neurology
https://www.readbyqxmd.com/read/28108332/sex-dependent-effects-of-early-life-inflammatory-pain-on-sucrose-intake-and-sucrose-associated-hippocampal-arc-expression-in-adult-rats
#8
Yoko O Henderson, Rebecca Nalloor, Almira Vazdarjanova, Anne Z Murphy, Marise B Parent
We hypothesize that dorsal hippocampal (dHC) neurons, which are critical for episodic memory, form a memory of a meal and inhibit the initiation of the next meal and the amount ingested during that meal. In support, we showed previously that (1) consuming a sucrose meal induces expression of the synaptic plasticity marker activity-regulated cytoskeleton-associated protein (Arc) in dHC neurons and (2) reversible inactivation of these neurons immediately following a sucrose meal accelerates the onset of the next meal and increases the size of that meal...
January 17, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28108227/cerebral-blood-flow-autoregulation-is-impaired-in-schizophrenia-a-pilot-study
#9
Hsiao-Lun Ku, Jiunn-Kae Wang, Hsin-Chien Lee, Timothy Joseph Lane, I-Chao Liu, Yung-Chan Chen, Yao-Tung Lee, I-Cheng Lin, Chia-Pei Lin, Chaur-Jong Hu, Nai-Fang Chi
Patients with schizophrenia have a higher risk of cardiovascular diseases and higher mortality from them than does the general population; however, the underlying mechanism remains unclear. Impaired cerebral autoregulation is associated with cerebrovascular diseases and their mortality. Increased or decreased cerebral blood flow in different brain regions has been reported in patients with schizophrenia, which implies impaired cerebral autoregulation. This study investigated the cerebral autoregulation in 21 patients with schizophrenia and 23 age- and sex-matched healthy controls...
January 17, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28108066/does-a-similar-procedure-result-in-similar-survival-for-women-and-men-undergoing-isolated-coronary-artery-bypass-grafting
#10
Tamer Attia, Colleen G Koch, Penny L Houghtaling, Eugene H Blackstone, Ellen Mayer Sabik, Joseph F Sabik
OBJECTIVES: To (1) identify sex-related differences in risk factors and revascularization strategies for patients undergoing coronary artery bypass grafting (CABG), (2) assess whether these differences influenced early and late survival, and (3) determine whether clinical effectiveness of the same revascularization strategy was influenced by sex. METHODS: From January 1972 to January 2011, 57,943 adults-11,009 (19%) women-underwent primary isolated CABG. Separate models for long-term mortality were developed for men and women, followed by assessing sex-related differences in strength of risk factors (interaction terms)...
November 21, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28108044/relationship-of-muscle-mass-determined-by-dexa-with-spirometric-results-in-healthy-individuals
#11
Rafael Martín Holguera, Ana Isabel Turrión Nieves, Rosa Rodríguez Torres, María Concepción Alonso
INTRODUCTION: Muscle mass maybe a determining factor in the variability of spirometry results in individuals of the same sex and age who have similar anthropometric characteristics. The aim of this study was to determine the association between spirometric results from healthy individuals and their muscle mass assessed by dual energy X-ray absorptiometry (DEXA). METHODS: A sample of 161 women and 144 men, all healthy non-smokers, was studied. Ages ranged from18 to77years...
January 17, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28107900/quality-of-sleep-in-renal-transplant-recipients-and-patients-on-hemodialysis
#12
Paraskevi G Liaveri, Dimitris Dikeos, Ioannis Ilias, Eirini P Lygkoni, Ioannis N Boletis, Chryssanthi Skalioti, Thomas Paparrigopoulos
BACKGROUND: Sleep disorders are very common in patients with chronic kidney disease and they may not always subside after kidney transplantation. AIM AND METHODS: The aim of this cross-sectional study was to evaluate the self-reported quality of sleep, insomnia problems in particular, and examine the factors that disturb sleep of kidney transplant recipients (KTx: n=152) in comparison to age- and sex-matched patients on dialysis (HD: n=67) and participants with normal renal function (NOR: n=49), through the administration of the Athens Insomnia Scale (AIS) at least six months after transplantation...
February 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28107888/anxiety-and-anger-immediately-prior-to-myocardial-infarction-and-long-term-mortality-characteristics-of-high-risk-patients
#13
Loes Smeijers, Elizabeth Mostofsky, Geoffrey H Tofler, James E Muller, Willem J Kop, Murray A Mittleman
OBJECTIVE: Acute high levels of anger and anxiety are associated with an elevated risk of myocardial infarction (MI) in the following two hours. MIs preceded by these acute negative emotions may also have a poor long-term prognosis, but information about high-risk patients is lacking. We examined whether young age and female sex are associated with MIs that are preceded by negative emotions and whether age and sex moderate the subsequent increased mortality risk following MI preceded by negative emotions...
February 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28107869/measles-outbreaks-in-the-kyeongin-area-of-the-republic-of-korea-2013-2014-a-single-center-experience-in-a-country-of-measles-elimination
#14
Sun Hyoung Park, Dong Hun Lee, Jang Yong Jin, Young-Lim Shin, Meeyong Shin, Sung Shin Kim, Won Suk Suh, Jae Ock Park, Yong Hee Hong
OBJECTIVE: To identify the source of infection and determine the clinical features and laboratory finding of measles infection. METHODS: In 27 measles patients, except for 3 adult patients, the rest of 24 pediatric measles cases were analyzed with regard to age, sex, immunization status, transmission routes and molecular genotyping of measles virus. Eighteen measles patients who admitted in isolation ward were set apart to investigate clinical findings and its correlation with laboratory characteristics...
January 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28107717/diclofenac-can-exhibit-estrogenic-modes-of-action-in-male-xenopus-laevis-and-affects-the-hypothalamus-pituitary-gonad-axis-and-mating-vocalizations
#15
Norah Johanna Efosa, Wibke Kleiner, Werner Kloas, Frauke Hoffmann
Diclofenac (DCF) is a non-steroidal analgesic and antiphlogistic. Due to its tremendous use, DCF can be found in the environment, especially in sewage, but also surface waters, ground and drinking water. Previous studies indicated that DCF can modulate the reproductive physiology of fish by altering the expression of important key enzymes of the hypothalamus-pituitary-gonad-axis (HPG-axis) and might act as an estrogenic endocrine disrupting chemical (EDC). Other studies, however, demonstrated that DCF does not exhibit any estrogenicity...
January 6, 2017: Chemosphere
https://www.readbyqxmd.com/read/28107506/association-between-increased-gastric-juice-acidity-and-sliding-hiatal-hernia-development-in-humans
#16
Hiroshi Kishikawa, Kayoko Kimura, Asako Ito, Kyoko Arahata, Sakiko Takarabe, Shogo Kaida, Takanori Kanai, Soichiro Miura, Jiro Nishida
OBJECTIVES: Several clinical factors; overweight, male gender and increasing age, have been implicated as the etiology of hiatal hernia. Esophageal shortening due to acid perfusion in the lower esophagus has been suggested as the etiological mechanism. However, little is known about the correlation between gastric acidity and sliding hiatus hernia formation. This study examined whether increased gastric acid secretion is associated with an endoscopic diagnosis of hiatal hernia. METHODS: A total of 286 consecutive asymptomatic patients (64 were diagnosed as having a hiatal hernia) who underwent upper gastrointestinal endoscopy were studied...
2017: PloS One
https://www.readbyqxmd.com/read/28107456/social-inequalities-and-depressive-symptoms-in-adults-the-role-of-objective-and-subjective-socioeconomic-status
#17
Jens Hoebel, Ulrike E Maske, Hajo Zeeb, Thomas Lampert
BACKGROUND: There is substantial evidence that lower objective socioeconomic status (SES)-as measured by education, occupation, and income-is associated with a higher risk of depression. Less is known, however, about associations between perceptions of social status and the prevalence of depression. This study investigated associations of both objective SES and subjective social status (SSS) with depressive symptoms among adults in Germany. METHODS: Data were obtained from the 2013 special wave of the German Health Update study, a national health survey of the adult population in Germany...
2017: PloS One
https://www.readbyqxmd.com/read/28107391/recreational-drug-use-among-chinese-msm-and-transgender-individuals-results-from-a-national-online-cross-sectional-study
#18
Peizhen Zhao, Songyuan Tang, Cheng Wang, Ye Zhang, John Best, Thitikarn May Tangthanasup, Shujie Huang, Bin Yang, Chongyi Wei, Joseph D Tucker, Weiming Tang
BACKGROUND: Recreational drug use has increased considerably among Chinese men who have sex with men (MSM). The phenomenon has the potentially to increase HIV transmission among Chinese MSM. The aims of this study were: 1) to investigate the prevalence of recreational drug use among Chinese MSM, and 2) to explore the correlation between gay smartphone based sex-seeking applications (gay apps), HIV/STIs testing, group sex, commercial sex, sexual roles and poppers use among Chinese MSM...
2017: PloS One
https://www.readbyqxmd.com/read/28107362/population-muscle-strength-predicts-olympic-medal-tallies-evidence-from-20-countries-in-the-pure-prospective-cohort-study
#19
Darryl P Leong, Martin McKee, Salim Yusuf
BACKGROUND: National sporting achievement at the Olympic Games is important for national pride and prestige, and to promote participation in sport. Summer Olympic Games medal tallies have been associated with national wealth, and also social development and healthcare expenditure. It is uncertain however, how these socioeconomic factors translate into Olympic success. The objective of this study was therefore to examine the relationship between population muscle strength and Olympic medal tallies...
2017: PloS One
https://www.readbyqxmd.com/read/28107351/high-concentrations-of-angiopoietin-like-protein-4-detected-in-serum-from-patients-with-rheumatoid-arthritis-can-be-explained-by-non-specific-antibody-reactivity
#20
Elena Makoveichuk, Toralph Ruge, Solveig Nilsson, Anna Södergren, Gunilla Olivecrona
Angiopoietin-like protein 4 (ANGPTL4) is suggested to be a master regulator of plasma triglyceride metabolism. Our aim was to study whether the previously reported high levels of ANGPTL4 detected in serum from patients with rheumatoid arthritis (RA) by ELISA was due to any specific molecular form of this protein (oligomers, monomers or fragments). ANGPTL4 levels were first determined in serum from 68 RA patients and 43 age and sex matched control subjects and the mean values differed by a factor of 5.0. Then, ANGPTL4 was analyzed after size exclusion chromatography (SEC) of serum samples...
2017: PloS One
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