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https://www.readbyqxmd.com/read/29778077/selection-of-plants-for-phytoremediation-of-barium-polluted-flooded-soils
#1
Paulo Roberto Cleyton de Castro Ribeiro, Douglas Gomes Viana, Fábio Ribeiro Pires, Fernando Barboza Egreja Filho, Robson Bonomo, Alberto Cargnelutti Filho, Luiz Fernando Martins, Leila Beatriz Silva Cruz, Mauro César Pinto Nascimento
The use of barite (BaSO4) in drilling fluids for oil and gas activities makes barium a potential contaminant in case of spills onto flooded soils, where low redox conditions may increase barium sulfate solubility. In order to select plants able to remove barium in such scenarios, the following species were evaluated on barium phytoextraction capacity: Brachiaria arrecta, Cyperus papyrus, Eleocharis acutangula, E. interstincta, Nephrolepsis cf. rivularis, Oryza sativa IRGA 424, O. sativa BRS Tropical, Paspalum conspersum, and Typha domingensis...
May 10, 2018: Chemosphere
https://www.readbyqxmd.com/read/29773050/the-importance-of-complying-with-vaccination-protocols-in-developed-countries-anti-vax-hysteria-and-the-spread-of-severe-preventable-diseases
#2
Franco Pandolfi, Laura Franza, Laura Todi, Valentina Carusi, Michele Centrone, Alessandro Bonomo, Estelle E Newton, Domenico Schiavino, Eleonora Nucera
BACKGROUND: Vaccines are very effective medical tools for disease prevention and life span increase. Controversies have raised concern about their safety, from autism to polio vaccine contamination with simian virus 40 (SV-40). Hysteria surrounding vaccine-associated risks has resulted in a declining number of vaccinations in developed countries. Outbreaks of vaccine-preventable diseases (e.g. measles) have occurred in Europe and North America, causing also some causalities. OBJECTIVES: In this review, data on safety and efficacy of vaccines are discussed, showing that the benefits of vaccines far outweigh the risks and that it is important to comply with vaccination protocols, to avoid spreading of severe, preventable diseases...
May 17, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29759570/re-irradiation-as-salvage-treatment-in-recurrent-glioblastoma-a-comprehensive-literature-review-to-provide-practical-answers-to-frequently-asked-questions
#3
REVIEW
Silvia Scoccianti, Giulio Francolini, Giulio Alberto Carta, Daniela Greto, Beatrice Detti, Gabriele Simontacchi, Luca Visani, Muhammed Baki, Linda Poggesi, Pierluigi Bonomo, Monica Mangoni, Isacco Desideri, Stefania Pallotta, Lorenzo Livi
The primary aim of this review is to provide practical recommendations in terms of fractionation, dose, constraints and selection criteria to be used in the daily clinical routine. Based on the analysis of the literature reviewed, in order to keep the risk of severe side effects ≤3,5%, patients should be stratified according to the target volume. Thus, patients should be treated with different fractionation and total EQD2 (<12.5 ml: EQD2 < 65 Gy with radiosurgery; >12.5 ml and <35 ml: EQD2 < 50 Gy with hypofractionated stereotactic radiotherapy; >35 ml and <50 ml: EQD2 < 36 Gy with conventionally fractionated radiotherapy)...
June 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29756964/a%C3%A3-ai-improves-non-alcoholic-fatty-liver-disease-nafld-induced-by-fructose
#4
Mayara Medeiros de Freitas Carvalho, Larissa Lélis Teixeira Reis, Juliana Márcia Macedo Lopes, Nara Nunes Lage, Joyce Ferreira da Costa Guerra, Helena Porto Zago, Larissa De Freitas Bonomo, Renata Rebeca Pereira, Wanderson Geraldo de Lima, Marcelo Eustáquio Silva, Maria Lucia Pedrosa
INTRODUCTION: the excessive consumption of fructose can cause liver damage, characteristic of non-alcoholic fatty liver disease (NAFLD) associated with changes in lipid metabolism and antioxidant defenses. Açai, the fruit of Euterpe oleraceaMart., has demonstrated numerous biological activities, including anti-inflammatory, antioxidant, and lipid metabolism modulating action. OBJECTIVE: we evaluated the benefits of açai supplementation on liver damage caused by replacing starch with fructose in rats...
February 16, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29748534/activated-dendritic-cells-modulate-proliferation-and-differentiation-of-human-myoblasts
#5
Leandro Ladislau, Débora M Portilho, Tristan Courau, Alhondra Solares-Pérez, Elisa Negroni, Jeanne Lainé, David Klatzmann, Adriana Bonomo, Yves Allenbach, Olivier Benveniste, Ingo Riederer, Wilson Savino, Vincent Mouly, Gillian Butler-Browne, Claudia F Benjamim
Idiopathic Inflammatory Myopathies (IIMs) are a heterogeneous group of autoimmune diseases affecting skeletal muscle tissue homeostasis. They are characterized by muscle weakness and inflammatory infiltration with tissue damage. Amongst the cells in the muscle inflammatory infiltration, dendritic cells (DCs) are potent antigen-presenting and key components in autoimmunity exhibiting an increased activation in inflamed tissues. Since, the IIMs are characterized by the focal necrosis/regeneration and muscle atrophy, we hypothesized that DCs may play a role in these processes...
May 10, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29744859/prescription-opioid-use-in-pregnancy
#6
REVIEW
Julie Blandthorn, Laura Leung, Yuan Loke, D Martyn Lloyd-Jones, Robin Thurman, Ellen Bowman, Yvonne Bonomo
Prescription medications, including opioid analgesics, are increasingly prescribed in Australia and internationally. More women are presenting in pregnancy with prescription opioid use which can potentially cause harm to the mother and fetus. This article outlines the different types of prescription opioids, defines how prescription opioid use disorder presents clinically and suggests a rational clinical approach to assess and manage patients in the context of pregnancy and their infants.
May 10, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29718108/the-antiepileptic-drug-lamotrigine-inhibits-the-cyp17a1-lyase-reaction-in-vitro
#7
Cecilie Hurup Munkboel, Lise Rudbæk Christensen, Julie Islin, Silvia Bonomo, Lars Olsen, Flemming Steen Jørgensen, Bjarne Styrishave
The potential endocrine disrupting effects of the commonly prescribed anti-epileptic drug lamotrigine (LAM) was investigated using the H295R steroidogenic in vitro assay and computational chemistry methods. The H295R cells were exposed to different concentrations of LAM and a multi-steroid LC-MS/MS method was applied to quantify the amount of secreted steroid hormones. LAM affected several steroid hormones in the steroidogenesis at therapeutic concentrations. All progestagens as well as 11-deoxycorticosterone and corticosterone increased 100-200% with increasing concentrations of LAM suggesting a selective inhibitory effect of LAM on CYP17A1, in particular on the lyase reaction...
April 26, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29716256/a-comparison-of-three-geoacoustic-models-using-bayesian-inversion-and-selection-techniques-applied-to-wave-speed-and-attenuation-measurements
#8
Anthony L Bonomo, Marcia J Isakson
Many geoacoustic models have been developed to study sandy sediments. In this work, Bayesian inference techniques are used to compare three such models: the VGS(λ) model, the most recent of Buckingham's viscous grain-shearing models, the Biot-Stoll poroelastic model, and an extension to the Biot-Stoll model proposed by Chotiros called the corrected and reparametrized extended Biot (CREB) model. First, Bayesian inversion is applied to wave speed and attenuation measurements previously made in the laboratory to determine the degree to which each of the model input parameters can be resolved by wave speed and attenuation data...
April 2018: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/29714662/safety-of-concurrent-adjuvant-radiotherapy-and-chemotherapy-for-locally-advanced-soft-tissue-sarcoma
#9
Daniela Greto, Mauro Loi, Calogero Saieva, Cristina Muntoni, Camilla Delli Paoli, Carlotta Becherini, Cinzia Ciabatti, Marco Perna, Domenico Campanacci, Francesca Terziani, Giovanni Beltrami, Guido Scoccianti, Pierluigi Bonomo, Icro Meattini, Isacco Desideri, Gabriele Simontacchi, Monica Mangoni, Lorenzo Livi
INTRODUCTION: This retrospective study analyzes the safety and feasibility of concurrent chemoradiotherapy (CRT) in adjuvant treatment of soft tissue sarcoma (STS). METHODS: A total of 158 patients with STS were retrospectively analyzed. Anthracycline-based computed tomography was performed in high-risk patients. Acute radiotherapy toxicity and chemotherapy-related toxicity were assessed according to the Common Terminology Criteria for Adverse Events 4.0; late radiotherapy toxicity was recorded according to Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer criteria...
April 1, 2018: Tumori
https://www.readbyqxmd.com/read/29689319/experiences-of-young-adults-with-type-1-diabetes-while-using-alcohol-and-recreational-drugs-an-interpretative-phenomenological-analysis-ipa-of-semi-structured-interviews
#10
Adam Pastor, Casey L O'Brien, Jessie Teng, Jennifer Conn, Margaret Loh, Lisa Collins, Richard MacIsaac, Yvonne Bonomo
AIMS: Alcohol and recreational drug use is common in young adults with type 1 diabetes (T1DM) and may account for increased morbidity and mortality. This study explores the motivations and experiences unique to this population while using alcohol and recreational drugs. METHODS: Semi-structured interviews focusing on substance use were performed with 16 young adults aged 18-35 with T1DM who drink alcohol (at least 50 grams, 5 Australian standard drinks, in a single session) and/or used recreational drugs...
April 21, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29680579/the-continuing-challenge-of-metallo-%C3%AE-lactamase-inhibition-mechanism-matters
#11
REVIEW
Lin-Cheng Ju, Zishuo Cheng, Walter Fast, Robert A Bonomo, Michael W Crowder
Metallo-β-lactamases (MBLs) are a significant clinical problem because they hydrolyze and inactivate nearly all β-lactam-containing antibiotics. These 'lifesaving drugs' constitute >50% of the available contemporary antibiotic arsenal. Despite the global spread of MBLs, MBL inhibitors have not yet appeared in clinical trials. Most MBL inhibitors target active site zinc ions and vary in mechanism from ternary complex formation to metal ion stripping. Importantly, differences in mechanism can impact pharmacology in terms of reversibility, target selectivity, and structure-activity relationship interpretation...
April 18, 2018: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/29675000/exploring-additional-dimensions-of-complexity-in-inhibitor-design-for-serine-%C3%AE-lactamases-mechanistic-and-intra-and-inter-molecular-chemistry-approaches
#12
REVIEW
Focco van den Akker, Robert A Bonomo
As a bacterial resistance strategy, serine β-lactamases have evolved from cell wall synthesizing enzymes known as penicillin-binding proteins (PBP), by not only covalently binding β-lactam antibiotics but, also acquiring mechanisms of deacylating these antibiotics. This critical deacylation step leads to release of hydrolyzed and inactivated β-lactams, thereby providing resistance for the bacteria against these antibiotics targeting the cell wall. To combat β-lactamase-mediated antibiotic resistance, numerous β-lactamase inhibitors were developed that utilize various strategies to inactivate the β-lactamase...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29672670/predicting-influenza-h3n2-vaccine-efficacy-from-evolution-of-the-dominant-epitope
#13
Melia E Bonomo, Michael W Deem
We predict vaccine efficacy with a measure of antigenic distance between influenza A(H3N2) and candidate vaccine viruses based on amino acid substitutions in the dominant epitopes. In 2016-2017, our model predicts 19% efficacy compared to 20% observed. This tool assists candidate vaccine selection by predicting human protection against circulating strains.
April 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29651712/prognostic-impact-of-nodal-relapse-in-definitive-prostate-only-irradiation
#14
Mauro Loi, Luca Incrocci, Isacco Desideri, Pierluigi Bonomo, Beatrice Detti, Gabriele Simontacchi, Daniela Greto, Emanuela Olmetto, Giulio Francolini, Icro Meattini, Lorenzo Livi
BACKGROUND: Whole pelvic irradiation in prostate cancer patients might prevent metastatic spread of cancer cells through lymphatic drainages in patients eligible for definitive radiotherapy, but its use has declined in the last decades in favor of prostate-only irradiation (POI). The aim of our study is to assess the incidence of pelvic lymph nodal relapse and outcome in prostate cancer patients receiving POI. MATERIALS AND METHODS: Data from 207 consecutive patients were collected...
April 12, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29627985/strategic-approaches-to-overcome-resistance-against-gram-negative-pathogens-using-%C3%AE-lactamase-inhibitors-and-%C3%AE-lactam-enhancers-activity-of-three-novel-diazabicyclooctanes-wck-5153-zidebactam-wck-5107-and-wck-4234
#15
Krisztina M Papp-Wallace, Nhu Q Nguyen, Michael R Jacobs, Christopher R Bethel, Melissa D Barnes, Vijay Kumar, Saralee Bajaksouzian, Susan D Rudin, Philip N Rather, Satish Bhavsar, Tadiparthi Ravikumar, Prasad K Deshpande, Vijay Patil, Ravindra Yeole, Sachin S Bhagwat, Mahesh V Patel, Focco van den Akker, Robert A Bonomo
Limited treatment options exist to combat infections caused by multidrug-resistant (MDR) Gram-negative bacteria possessing broad-spectrum β-lactamases. The design of novel β-lactamase inhibitors is of paramount importance. Here, three novel diazabicyclooctanes (DBOs), WCK 5153, zidebactam (WCK 5107), and WCK 4234 (compounds 1-3, respectively), were synthesized and biochemically characterized against clinically important bacteria. Compound 3 inhibited class A, C, and D β-lactamases with unprecedented k2 / K values against OXA carbapenemases...
April 20, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29618394/comparison-of-predictors-and-mortality-between-bloodstream-infections-caused-by-esbl-producing-escherichia-coli-and-esbl-producing-klebsiella-pneumoniae
#16
Oded Scheuerman, Vered Schechner, Yehuda Carmeli, Belen Gutiérrez-Gutiérrez, Esther Calbo, Benito Almirante, Pier-Luigy Viale, Antonio Oliver, Patricia Ruiz-Garbajosa, Oriol Gasch, Monica Gozalo, Johann Pitout, Murat Akova, Carmen Peña, Jose Molina, Alicia Hernández-Torres, Mario Venditti, Nuria Prim, Julia Origüen, German Bou, Evelina Tacconelli, Maria Tumbarello, Axel Hamprecht, Ilias Karaiskos, Cristina de la Calle, Federico Pérez, Mitchell J Schwaber, Joaquin Bermejo, Warren Lowman, Po-Ren Hsueh, Carolina Navarro-San Francisco, Robert A Bonomo, David L Paterson, Alvaro Pascual, Jesus Rodríguez-Baño
OBJECTIVETo compare the epidemiology, clinical characteristics, and mortality of patients with bloodstream infections (BSI) caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (ESBL-EC) versus ESBL-producing Klebsiella pneumoniae (ESBL-KP) and to examine the differences in clinical characteristics and outcome between BSIs caused by isolates with CTX-M versus other ESBL genotypesMETHODSAs part of the INCREMENT project, 33 tertiary hospitals in 12 countries retrospectively collected data on adult patients diagnosed with ESBL-EC BSI or ESBL-KP BSI between 2004 and 2013...
April 5, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29610205/relebactam-is-a-potent-inhibitor-of-the-kpc-2-%C3%AE-lactamase-and-restores-the-susceptibility-of-imipenem-against-kpc-producing-enterobacteriaceae
#17
Krisztina M Papp-Wallace, Melissa D Barnes, Jim Alsop, Magdalena A Taracila, Christopher R Bethel, Scott A Becka, David van Duin, Barry N Kreiswirth, Keith S Kaye, Robert A Bonomo
The imipenem-relebactam combination is in development as a potential treatment regimen for infections caused by Enterobacteriaceae possessing complex β-lactamase backgrounds. Relebactam is a β-lactamase inhibitor that possesses the diazabicyclooctane core similar to avibactam, however relebactam's R1 side chain also includes a piperidine ring compared to the carboxyamide of avibactam. Here, we investigated the inactivation of Klebsiella pneumoniae carbapenemase (KPC-2), the most widespread class A carbapenemase, by relebactam and performed susceptibility testing with imipenem-relebactam using KPC-producing clinical isolates of Enterobacteriaceae...
April 2, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29594250/anti-pd-l1-durvalumab-combined-with-cetuximab-and-radiotherapy-in-locally-advanced-squamous-cell-carcinoma-of-the-head-and-neck-a-phase-i-ii-study-ducro
#18
Pierluigi Bonomo, Isacco Desideri, Mauro Loi, Monica Mangoni, Mariangela Sottili, Livia Marrazzo, Cinzia Talamonti, Daniela Greto, Stefania Pallotta, Lorenzo Livi
Introduction and background: Head and neck squamous cell carcinoma (HNSCC) has been increasingly recognized as an immune suppressive malignancy. The efficacy of immune checkpoint inhibitors (ICI's) in the context of recurrent/metastatic (R/M) setting anticipates the possible integration of immunotherapy into the therapeutic armamentarium of locally advanced disease. Durvalumab (DUR) is a humanized monoclonal IgG1, anti-PD-L1 antibody with promising data in R/M HNSCC. The aim of our study is to test the antitumor activity of a combined regimen incorporating an immune checkpoint inhibitor into a conventional bio-radiation strategy for the cure of unfavorable locally advanced HNSCC...
February 2018: Clinical and translational radiation oncology
https://www.readbyqxmd.com/read/29582320/soft-tissue-sarcomas-new-opportunity-of-treatment-with-parp-inhibitors
#19
Monica Mangoni, Mariangela Sottili, Giulia Salvatore, Domenico Campanacci, Guido Scoccianti, Giovanni Beltrami, Camilla Delli Paoli, Luca Dominici, Virginia Maragna, Emanuela Olmetto, Icro Meattini, Isacco Desideri, Pierluigi Bonomo, Daniela Greto, Lorenzo Livi
BACKGROUND: Poly(ADP-ribose) polymerases (PARP) are a large family of enzymes involved in several cellular processes, including DNA single-strand break repair via the base-excision repair pathway. PARP inhibitors exert antitumor activity by both catalytic PARP inhibition and PARP-DNA trapping, moreover PARP inhibition represents a potential synthetic lethal approach against cancers with specific DNA-repair defects. Soft tissue sarcoma (STSs) are a heterogeneous group of mesenchymal tumors with locally destructive growth, high risk of recurrence and distant metastasis...
March 26, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29573977/triple-negative-apocrine-carcinomas-as-a-distinct-subtype-of-triple-negative-breast-cancer-a-case-control-study
#20
Icro Meattini, Donato Pezzulla, Calogero Saieva, Marco Bernini, Lorenzo Orzalesi, Luis Jose Sanchez, Isacco Desideri, Giulio Francolini, Pierluigi Bonomo, Daniela Greto, Mauro Loi, Monica Mangoni, Alessio Bruni, Jacopo Nori, Vania Vezzosi, Simonetta Bianchi, Lorenzo Livi
BACKGROUND: Invasive triple negative apocrine carcinoma (TNAC) of the breast is a rare type of triple negative breast cancer. Several studies reported significantly distinct prognosis for TNAC when compared with most of the non-apocrine triple negative (NATN) tumors. This is a case-control study reporting onoutcomes from our long-term single-center experience. PATIENTS AND METHODS: We analyzed the clinicopathologic features of a series of 46 TNAC tumors treated in a 15-year period...
March 2, 2018: Clinical Breast Cancer
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