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https://www.readbyqxmd.com/read/28632510/itraq-based-quantitative-proteomic-analysis-of-lungs-in-murine-polymicrobial-sepsis-with-hydrogen-gas-treatment
#1
Yingxue Bian, Chao Qin, Yuchang Xin, Yang Yu, Hongguang Chen, Guolin Wang, Keliang Xie, Yonghao Yu
Sepsis-associated acute lung injury (ALI), which carries a high morbidity and mortality in patients, has no effective therapeutic strategies to date. Our group have already reported that hydrogen gas (H2) exerts a protective effect against sepsis in mice. However, the molecular mechanisms underlying H2 treatment are not fully understood. This study investigated the effects of H2 on lung injuries in septic mice through the iTRAQ-based quantitative proteomic analysis. Male ICR mice used in this study were subjected to cecal ligation and puncture (CLP) or sham operation...
June 19, 2017: Shock
https://www.readbyqxmd.com/read/28629818/corydalis-hendersonii-hemsl-protects-against-myocardial-injury-by-attenuating-inflammation-and-fibrosis-via-nf-%C3%AE%C2%BAb-and-jak2-stat3-signaling-pathways
#2
Ruifeng Bai, Xu Yin, Xiao Feng, Yuan Cao, Yan Wu, Zhixiang Zhu, Chun Li, Pengfei Tu, Xingyun Chai
ETHNOPHARMACOLOGICAL RELEVANCE: Corydalis hendersonii Hemsl. (CH) with heat clearing and detoxifying effects are well described in Tibetan folk medicine. It has been used for centuries in China largely for the treatment of high altitude polycythemia, a pathophysiological condition referred to "plethora" in Tibetan medicine, hypertension, hepatitis, edema, gastritis, and other infectious diseases. AIM OF THE STUDY: To investigate the cardioprotective effects of Corydalis hendersonii extract in an ICR mouse model of myocardial ischemic injury...
June 16, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28628308/molecular-insights-into-the-transformation-of-dissolved-organic-matter-in-landfill-leachate-concentrate-during-biodegradation-and-coagulation-processes-using-esi-ft-icr-ms
#3
Ziwen Yuan, Chen He, Quan Shi, Chunming Xu, Zhenshan Li, Chengzhai Wang, Huazhang Zhao, Jinren Ni
Landfill leachate concentrate is a type of refractory organic wastewater with high environmental risk. Identification of refractory components and insights into the molecular transformations of the organics are essential for the development of efficient treatment process. In this report, molecular compositions of dissolved organic matter (DOM) in leachate concentrate, as well as changes after anaerobic/aerobic biodegradation and coagulation with salts, were characterized using electrospray ionization (ESI) coupled with Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS)...
June 19, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28627592/triptolide-exerts-protective-effects-against-fibrosis-following-ileocolonic-anastomosis-by-mechanisms-involving-the-mir-16-1-hsp70-pathway-in-il-10-deficient-mice
#4
Hong-Wei Hou, Jin-Min Wang, Dong Wang, Rong Wu, Zhen-Ling Ji
Surgeries, particularly ileocecal resection (ICR), are often required in the treatment of Crohn's disease (CD). However, recurrences are common for patients who undergo ICR, and anastomotic fibrosis is the main cause of re-operation. The present study aimed to investigate the therapeutic effects of triptolide (TPL) in ameliorating fibrosis following ileocolonic anastomosis. A model of IL‑10‑/‑ mice undergoing ICR was used to study postsurgical inflammation and fibrosis of anastomosis. For this purpsose, interleukin (IL)‑10‑/‑ mice were randomly divided into 3 groups as follows: the control group, the saline‑treated group subjected to ICR (ST‑ICR) and the TPL‑treated group subjected to ICR (TT‑ICR)...
June 9, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28626167/a-human-glucagon-like-peptide-1-albumin-recombinant-protein-with-prolonged-hypoglycemic-effect-provides-efficient-and-beneficial-control-of-glucose-metabolism-in-diabetic-mice
#5
Caina Li, Miaomiao Yang, Guojiang Hou, Shuainan Liu, Yi Huan, Dongan Yu, Sujuan Sun, Quan Liu, Shousheng Yan, Zhufang Shen
GW002 is a recombinant protein engineered by fusing the C-terminal region of human glucagon-like peptide-1 (GLP-1) to the N-terminal region of human serum albumin (HSA) with a peptide linker. This study aims to evaluate its anti-diabetic effects both in vitro and vivo. The GLP-1 receptor-dependent luciferase reporter plasmid was transiently transfected in NIT-1 cells to calculate the half-maximal concentration (EC50) for GLP-1 receptor activation, and normal ICR mice and diabetic KKAy mice were acutely injected with GW002 (1, 3 and 9 mg/kg) subcutaneously to evaluate the hypoglycemic action, while the diabetic KKAy and db/db mice were treated with GW002 once daily for 7 weeks to evaluate the effects on glucose metabolism...
June 17, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28626157/protein-restriction-does-not-affect-body-temperature-pattern-in-female-mice
#6
Goro A Kato, Hiroki Shichijo, Toshihiro Takahashi, Akio Shinohara, Tetsuo Morita, Chihiro Koshimoto
Daily torpor is a physiological adaptation in mammals and birds characterized by a controlled reduction of metabolic rate and body temperature during the resting phase of circadian rhythms. In laboratory mice, daily torpor is induced by dietary caloric restriction. However, it is not known which nutrients are related to daily torpor expression. To determine whether dietary protein is a key factor in inducing daily torpor in mice, we fed mice a protein-restricted (PR) diet that included only one-quarter of the amount of protein but the same caloric level as a control (C) diet...
June 13, 2017: Experimental Animals
https://www.readbyqxmd.com/read/28624941/does-static-electric-field-from-ultra-high-voltage-direct-current-transmission-lines-affect-male-reproductive-capacity-evidence-from-a-laboratory-study-on-male-mice
#7
Sixia Wu, Guoqing Di, Zhengguang Li
With the development of ultra-high-voltage direct-current (UHVDC) transmission technology and increase in transmission voltage, the issue of environmental static electric field (SEF) pollution is standing out and its possible health effects have caused much public attention. In this study, the effects of chronic exposure to SEF on reproductive capacity of male mice were investigated. Twenty Institute of Cancer Research (ICR) mice were exposed to SEF (56.3 ± 1.4 kV/m, 49 days) generated by a high-voltage device...
June 17, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28622435/single-port-laparoscopic-ileocaecal-resection-for-crohn-s-disease-a-multicentre-comparison-with-multi-port-laparoscopy
#8
Michele Carvello, E Joline de Groof, Anthony de Buck van Overstraeten, Matteo Sacchi, Albert M Wolthuis, Christianne J Buskens, André D'Hoore, Willem A Bemelman, Antonino Spinelli
BACKGROUND AND AIMS: Single port (SP) ileocecal resection (ICR) is an established technique but there are no large studies comparing SP and multi-port (MP) laparoscopic surgery in Crohn's disease (CD). The aim of this study was to compare postoperative pain scores and analgesia requirements after SP and MP laparoscopic ICR for CD. METHODS: This was a retrospective study of patients undergoing SP or MP ICR for CD in three tertiary referral centres from February 1999-October 2014...
June 16, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28621481/metal-free-room-temperature-oxygen-atom-transfer-in-the-n%C3%A2-o-co-redox-couple-as-catalyzed-by-si%C3%A2-ox-%C3%A2-x-2-5
#9
Xiaoyan Sun, Shaodong Zhou, Lei Yue, Maria Schlangen, Helmut Schwarz
The thermal reduction of N₂O by CO mediated by the metal-free cluster cations [Si₂Ox]*+ (x = 2-5) has been examined in the gas phase using Fourier transform-ion cyclotron resonance (FT-ICR) mass spectrometry in conjunction with quantum chemical calculations. Three successive oxidation/reduction steps occur starting from [Si₂O₂]*+ and N₂O to form eventually [Si₂O₅]*+; the latter as well as the intermediate oxide cluster ions react sequentially with CO molecules to regenerate [Si₂O₂]*+. Thus, full catalytic cycles occur at ambient conditions in the gas phase...
June 16, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28617322/chondroitin-sulfate-rich-extract-of-skate-cartilage-attenuates-lipopolysaccharide-induced-liver-damage-in-mice
#10
Yeong Ok Song, Mijeong Kim, Minji Woo, Jang-Mi Baek, Keon-Hee Kang, Sang-Ho Kim, Seong-Soo Roh, Chan Hum Park, Kap-Seop Jeong, Jeong-Sook Noh
The protective effects of a chondroitin sulfate-rich extract (CSE) from skate cartilage against lipopolysaccharide (LPS)-induced hepatic damage were investigated, and its mechanism of action was compared with that of chondroitin sulfate (CS) from shark cartilage. ICR mice were orally administrated 200 mg/kg body weight (BW) of CS or 400 mg/kg BW of CSE for 3 consecutive days, followed by a one-time intraperitoneal injection of LPS (20 mg/kg BW). The experimental groups were vehicle treatment without LPS injection (NC group), vehicle treatment with LPS injection (LPS group), CS pretreatment with LPS injection (CS group), and CSE pretreatment with LPS injection (CSE group)...
June 15, 2017: Marine Drugs
https://www.readbyqxmd.com/read/28616452/datasets-on-the-genomic-positions-of-the-mll1-morphemes-the-zfp57-binding-site-and-zfbs-morph-overlaps-in-the-build-mm9-of-the-mouse-genome
#11
Minou Bina, Phillip Wyss, Xiaohui C Song
While MLL1 activates gene expression in most tissues, ZFP57 represses transcription. MLL1 selectively interacts with a group of nonmethylated DNA sequences known as the MLL1 morphemes. ZFP57 associates with a methylated hexamer (ZFBS), dispersed in the genomic DNA segments known as Imprinted Control Regions (ICRs) and germline Differentially Methylated Regions (gDMRs), to maintain allele-specific gene repression. We have identified a set of composite DNA elements (ZFBS-Morph overlaps) that provides the sequence context of ZFBS in the canonical ICRs/gDMRs...
August 2017: Data in Brief
https://www.readbyqxmd.com/read/28614919/-effects-of-developmental-exposure-to-dehp-on-learning-and-memory-of-mice
#12
D J Wu, B B Luo, Q W Feng, Q N Wang
Objective: To investigate the effects of developmental exposure to DEHP on learning and memory of mice. Methods: Male littermates of ICR mice randomly assigned to five experimental groups (n=14 for each condition) on PND4 to receive distilled water, vehicle and 10, 50 and 200 mg/ (kg·d) DEHP from PND5 to PND38 by gavage, weighing and recording body weight of mice. Open field task were conducted on PND 26 and Morris water maze task were begun from PND30 to PND 37 to evaluate spontaneous exploration activity and emotion, spatial learning and memory performance of pubertal mice, respectively...
April 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
https://www.readbyqxmd.com/read/28610480/induced-re-differentiation-of-human-chondrocytes-from-articular-cartilage-lesion-in-alginate-bead-culture-after-monolayer-de-differentiation-an-alternative-cell-source-for-cell-based-therapies
#13
Matthias Aurich, Gunther O Hofmann, Norman Best, Bernd Rolauffs
Human chondrocytes isolated from articular cartilage lesions as an alternative cell source to the standard non-weight-bearing notch biopsy site may hold clinical potential for cell-based therapies. The aim was to characterize human AC lesion site chondrocytes, compare them to notch chondrocytes, and to evaluate their re-differentiation potential after monolayer expansion and subsequent 3D alginate bead culture. Lesion chondrocytes from knee joints of 20 patients with ICRS grade 3 and 4 cartilage defects were analyzed ex vivo or cultured in primary alginate bead culture, monolayer expansion, or were re-differentiated in alginate culture following monolayer expansion...
June 13, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28608030/intracorneal-ring-segment-depth-in-keratoconus-patients-a-long-term-follow-up-study
#14
Saied Shahhoseini, Hassan Hashemi, Soheila Asgari
PURPOSE: To compare the actual depth of the tunnel created with femtosecond laser for intracorneal ring segment (ICRS) implantation with the target depth in keratoconus patients. METHODS: In this mix design study, eligible keratoconus patients were identified through chart review. The inclusion criterion was a history of ICRS implantation with femtosecond laser more than 6 months prior to enrollment. Participants underwent anterior segment optical coherence tomography using Spectralis (Heidelberg Engineering GmbH, Heidelberg, Germany) for depth measurement defined as the distance from the anterior corneal surface to anterior rim of the ring...
June 12, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28602296/comprehensive-qualification-and-quantification-of-triacylglycerols-with-specific-fatty-acid-chain-composition-in-horse-adipose-tissue-human-plasma-and-liver-tissue
#15
Ming Guan, Dongsheng Dai, Lin Li, Jinchao Wei, Hui Yang, Shilei Li, Yangyang Zhang, Yu Lin, Shaoxiang Xiong, Zhenwen Zhao
High levels of triacylglycerols (TGs) have been linked to cardiovascular disease and liver diseases. Comprehensively analyzing TGs is helpful to understand the TGs functions in these diseases. However, due to the existence of a large number of isomers TGs and the lack of commercial standards, precise analysis of individual triacylglycerol (TG) with specific fatty acid chain composition is full of challenge. In this work, ultra-performance liquid chromatography (UPLC) coupled with electrospray ionization (ESI) mass spectrometry (MS) were employed for comprehensive qualification and quantification of TGs with specific fatty acid chain composition in horse adipose tissue, human plasma and liver tissues including hepatocellular carcinoma (HCC) and para-carcinoma tissues...
September 1, 2017: Talanta
https://www.readbyqxmd.com/read/28599077/protective-efficacy-of-recombinant-cryptosporidium-parvum-cpprp1-sushi-domain-against-c-tyzzeri-infection-in-mice
#16
Y Huang, W Cao, K Shi, R Mi, K Lu, X Han, Z Chen
Until now there are no completely effective parasite-specific pharmaceuticals or immunotherapies for treatment against the zoonotic cryptosporidiosis. Sushi domain (CpSushi) is an important functional domain in Cryptosporidium parvum putative rhoptry protein-1 (CpPRP1) which is the only reported C. parvum rhoptry protein and may play key role in the course of invasion. Here, a 708 bp fragment encoding the CpSushi domain was amplified and expressed in E. coli. Immunofluorescence detection showed that CpSushi was located on the surface of C...
June 9, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28596540/preparation-and-in-vivo-characterization-of-51-mncl2-as-pet-tracer-of-ca-2-channel-mediated-transport
#17
Stephen A Graves, Reinier Hernandez, Hector F Valdovinos, Paul A Ellison, Jonathan W Engle, Todd E Barnhart, Weibo Cai, Robert J Nickles
Manganese has long been employed as a T1-shortening agent in magnetic resonance imaging (MRI) applications, but these techniques are limited by the biotoxicity of bulk-manganese. Positron emission tomography (PET) offers superior contrast sensitivity compared with MRI, and recent preclinical PET studies employing (52g)Mn (t1/2: 5.6 d, β(+): 29%) show promise for a variety of applications including cell tracking, neural tract tracing, immunoPET, and functional β-cell mass quantification. The half-life and confounding gamma emissions of (52g)Mn are prohibitive to clinical translation, but the short-lived (51)Mn (t1/2: 46 min, β(+): 97%) represents a viable alternative...
June 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28596048/impact-of-antigens-adjuvants-and-strains-on-sexually-dimorphic-antibody-response-to-vaccines-in-mice
#18
Xin Li, Sheng Guo, Lei Yang, Li Hua, Zhiqin Li, Xu Hao, Yongli Yu, Wei Sun, Liying Wang
Sexually dimorphic antibody response to vaccines has long been noticed. In addition to sex hormones, other factors such as antigens, adjuvants and strains of mice, as shown by indirect evidence, could also impact the sexual dimorphism. To clarify this, we immunized both gender mice of distinct strains with inactivated FMDV or HBsAg with or without adjuvants, and detected the specific antibody response of the mice. We found that in absence of adjuvants, the recombinant HBsAg but not the inactivated FMDV induced enhanced IgG antibody response in the female BALB/c mice...
June 5, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28590038/effects-of-estrogen-and-cimicifuga-racemosa-on-the-cardiac-norepinephrine-pathway-of-ovariectomized-rats
#19
Yao Liu, Jing Zhang, Shuya Liu, Wenjuan Wang, Xing Chen, Hai Jiang, Junlei Li, Ke Wang, Wenpei Bai, Haicheng Zhang, Lihua Qin
This study aimed to investigate the effects of estrogen and Cimicifuga racemosa on the stellate ganglion, cardiac norepinephrine pathway, and Ca(2+) /calmodulin-dependent protein kinase II (CaMK II). Forty adult female Sprague Dawley rats were randomly divided into four groups: SHAM, ovariectomized (OVX), ovariectomized with estrogen treatment (E2), and ovariectomized with Cimicifuga racemosa treatment (iCR). After 4 weeks of treatment, norepinephrine (NE) content was determined by high-performance liquid chromatography, and dopamine beta-hydroxylase (DBH) and norepinephrine transporter (NET) expression was detected by immunohistochemistry...
June 7, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28589876/short-term-results-after-arthroscopic-resection-of-synovial-plicae-in-the-radiohumeral-joint-a-case-series-of-64-procedures
#20
Jens Brahe Pedersen, Pia Kjær Kristensen, Peter Mønsted, Theis Muncholm Thillemann
INTRODUCTION: Painful Synovial Plicae (SP) in the posterolateral corner of the radiohumeral joint may be confused with lateral epicondylitis. The SP may impinge between the radial head and the humeral capitellum causing pain and snapping. The aim of this study was to evaluate the short-term results after arthroscopic plica resection of the elbow. METHODS: In this case series, we included a consecutive series of 64 arthroscopies (60 patients) with arthroscopic plica resection of the elbow...
2017: SICOT-J
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