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https://www.readbyqxmd.com/read/28815219/conventional-nk-cells-and-ilc1-are-partially-ablated-in-the-livers-of-ncr1-icre-tbx21-fl-fl-mice
#1
Antonia O Cuff, Victoria Male
Mouse liver contains both Eomes-dependent conventional natural killer (cNK) cells and Tbet-dependent liver-resident type I innate lymphoid cells (ILC1). In order to better understand the role of ILC1, we attempted to generate mice that would lack liver ILC1, while retaining cNK, by conditional deletion of Tbet in NKp46+ cells. Here we report that the Ncr1 (iCre)Tbx21 (fl/fl) mouse has a roughly equivalent reduction in both the cNK and ILC1 compartments of the liver, limiting its utility for investigating the relative contributions of these two cell types in disease models...
2017: Wellcome Open Research
https://www.readbyqxmd.com/read/28814403/oxidized-low-density-lipoprotein-induced-microparticles-promote-endothelial-monocyte-adhesion-via-intercellular-adhesion-molecule-1
#2
Zhiwei Fu, Enchen Zhou, Xu Wang, Mingda Tian, Jian Kong, Jizhao Li, Liang Ji, Chenguang Niu, Haitao Shen, Shuying Dong, Changjie Liu, Alphons Vermorken, Belinda Belle Willard, Lingyun Zu, Lemin Zheng
Oxidized low density lipoprotein (oxLDL) accumulates early in atherosclerotic lesions and plays an important role in the progressive formation of atherosclerotic plaques. Endothelial derived microparticles (EMPs) form a heterogeneous population of < 1μm particles that shed from endothelial membranes upon activation. While EMPs are shown to be involved in atherosclerotic pathophysiology and progression, there is no report regarding to the relationship between oxLDL and EMPs. In this study we aim to determine the influence of oxLDL on endothelial microparticle release and the subsequent regulation of the endothelial activation...
August 16, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28811831/potent-phosphodiesterase-inhibition-and-nitric-oxide-release-stimulation-of-anti-impotence-thai-medicinal-plants-from-manosroi-iii-database
#3
Aranya Manosroi, Theeraphong Tangjai, Charinya Chankhampan, Worapaka Manosroi, Yaravee Najarut, Worapong Kitdamrongtham, Jiradej Manosroi
Seven plants in the top rank were selected from the "MANOSROI III" database using the two Thai keywords which meant impotence and sexual tonic. Boesenbergia rotunda (L.) Mansf. extract [EDP1-001(1)] gave the highest PDE inhibition activity of 4.36-fold sildenafil, a standard anti-impotence drug. Plumbago indica Linn. extract [EDP2-001(1)] exhibited the highest NO release stimulation activity of 666.85% which was 1.50-fold acetylcholine, a standard drug. Most selected plant extracts were nontoxic to EA.hy926 cells at 1...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28810691/improvement-of-implantation-potential-in-mouse-blastocysts-derived-from-ivf-by-combined-treatment-with-prolactin-epidermal-growth-factor-and-4-hydroxyestradiol
#4
Miki Takeuchi, Misato Seki, Etsuko Furukawa, Akihito Takahashi, Kyosuke Saito, Mitsuru Kobayashi, Kenji Ezoe, Emiko Fukui, Midori Yoshizawa, Hiromichi Matsumoto
STUDY QUESTION: Can supplementation of medium with prolactin (PRL), epidermal growth factor (EGF) and 4-hydroxyestradiol (4-OH-E2) prior to embryo transfer improve implantation potential in mouse blastocysts derived from IVF? SUMMARY ANSWER: Combined treatment with PRL, EGF and 4-OH-E2 improves mouse blastocyst implantation rates, while alone, each factor is ineffective. WHAT IS KNOWN ALREADY: Blastocyst dormancy during delayed implantation caused by ovariectomy is maintained by continued progesterone treatment in mice, and estrogen injection rapidly activates blastocysts to implantation-induced status in vivo...
August 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28808471/management-of-invasive-cervical-root-resorption-in-a-mandibular-canine-using-biodentine-as-a-restorative-material-a-case-report
#5
Leila Eftekhar, Hengameh Ashraf, Sanaa Jabbari
Invasive cervical root resorption (ICR) is the reversible/irreversible loss of tooth structure in the connective tissue attachment zone with unclear etiology. In the present case a history of periodontal surgery was presumed to be the predisposing factor. Early diagnosis and proper treatment may lead to long-term retention of the tooth. The tooth is usually asymptomatic and diagnosis is commonly made as a result of a routine radiographic finding. Cone-beam computed tomography (CBCT) is extremely useful in diagnosis and treatment planning of ICR...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28801212/intraoperative-validation-of-quantitative-t2-mapping-in-patients-with-articular-cartilage-lesions-of-the-knee
#6
Stefan Soellner, Axel Goldmann, Daniel Muelheims, Goetz H Welsch, Milena Pachowsky
OBJECTIVE: The aim of this study was to compare T2 relaxation times of knee cartilage with intraoperative results for the assessment of early osteoarthritis (OA) and to define T2 values for the differentiation between healthy and degenerated cartilage. DESIGN: Twenty-one patients with cartilage lesions or moderate OA were examined using 3T MRI. In this prospective study, a total of 882 regions of interest (ROIs) were examined by a sagittal, multi-echo, spin-echo T2 sequence and a morphological high-resolution three-dimensional, fat-saturated proton-density space sequence...
August 8, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28798780/gender-related-differences-in-long-term-outcome-among-high-risk-patients-with-myocardial-infarction-treated-invasively
#7
Julita Sarek, Anita Paczkowska, Bartosz Wilczyński, Paweł Francuz, Tomasz Podolecki, Radosław Lenarczyk, Beata Średniawa, Zbigniew Kalarus, Jacek Kowalczyk
INTRODUCTION: Treating acute myocardial infarction (AMI) with percutaneous coronary intervention (PCI) has an impact on improving long-term outcome. However, patients with other comorbidities are challenging, and are considered as a high-risk population. AIM: To assess gender-related differences in long-term prognosis after AMI among high-risk patients. MATERIAL AND METHODS: The single-center registry encompassed 4375 AMI patients treated with PCI...
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/28798533/a-spontaneous-myoepithelial-carcinoma-in-the-mammary-gland-of-an-aged-female-icr-cd-1-mouse
#8
Tsuyoshi Ito, Toshinori Yoshida, Katsumi Soma, Yoshitaka Katoh, Yuko Shimada, Aya Ohnuma-Koyama, Naofumi Takahashi, Yoshimasa Okazaki, Atsushi Shiga, Maki Kuwahara, Takanori Harada
We report a female Crlj:CD1(ICR) mouse with a spontaneous mammary gland tumor composed of biphasic tumor cells, i.e., epithelioid and spindle-shaped myoepithelial cells. Macroscopically, a subcutaneous mass, approximately 3 cm in diameter was found in the lumbodorsal region. Histopathologically, the epithelioid cells proliferated in an alveolar or nest-like growth pattern, occasionally forming glandular-like structures. On the other hand, the spindle-shaped cells proliferated in a sarcomatous pattern. Normal mammary gland was observed in the vicinity of the tumor...
July 2017: Journal of Toxicologic Pathology
https://www.readbyqxmd.com/read/28797100/mapping-the-contact-surfaces-in-the-lamin-a-aimp3-complex-by-hydrogen-deuterium-exchange-ft-icr-mass-spectrometry
#9
Yeqing Tao, Pengfei Fang, Sunghoon Kim, Min Guo, Nicolas L Young, Alan G Marshall
Aminoacyl-tRNA synthetases-interacting multifunctional protein3 (AIMP3/p18) is involved in the macromolecular tRNA synthetase complex via its interaction with several aminoacyl-tRNA synthetases. Recent reports reveal a novel function of AIMP3 as a tumor suppressor by accelerating cellular senescence and causing defects in nuclear morphology. AIMP3 specifically mediates degradation of mature Lamin A (LmnA), a major component of the nuclear envelope matrix; however, the mechanism of how AIMP3 interacts with LmnA is unclear...
2017: PloS One
https://www.readbyqxmd.com/read/28795575/accurate-identification-of-unknown-and-known-metabolic-mixture-components-by-combining-3d-nmr-with-ft-icr-ms-ms
#10
Cheng Wang, Lidong He, Dawei Li, Lei Bruschweiler-Li, Alan G Marshall, Rafael Bruschweiler
Metabolite identification in metabolomics samples is a key step that critically impacts downstream analysis. We recently introduced the SUMMIT NMR/MS hybrid approach for the identification of the molecular structure of unknown metabolites, based on the combination of NMR, mass spectrometry (MS), and combinatorial cheminformatics. Here, we demonstrate the feasibility of the approach for an untargeted analysis of both a model mixture and E. coli cell lysate, based on 2D/3D NMR experiments in combination with FT-ICR MS and MS/MS data...
August 10, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28794657/repeated-administration-of-mazindol-reduces-spontaneous-pain-related-behaviors-without-modifying-bone-density-and-microarchitecture-in-a-mouse-model-of-complete-freund-s-adjuvant-induced-knee-arthritis
#11
L E Robledo-González, A Martínez-Martínez, V M Vargas-Muñoz, R I Acosta-González, R Plancarte-Sánchez, M Anaya-Reyes, C Fernández Del Valle-Laisequilla, J G Reyes-García, J M Jiménez-Andrade
BACKGROUND: The role of dopaminergic system in the development of rheumatoid arthritis-related pain, a major symptom in this disease, has not been explored. Therefore, the anti-nociceptive effect of mazindol, a dopamine uptake inhibitor, was evaluated in a model of complete Freund's adjuvant (CFA)-induced arthritis. Furthermore, as studies have shown that the dopaminergic system regulates bone metabolism, the effect of mazindol on bone mass and microarchitecture was determined. METHODS: Adult ICR male mice received intra-articular injections of either CFA or saline into the right knee joint every week...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28792471/comparative-studies-on-behavioral-cognitive-and-biomolecular-profiling-of-icr-c57bl-6-and-its-sub-strains-suitable-for-scopolamine-induced-amnesic-models
#12
Govindarajan Karthivashan, Shin-Young Park, Joon-Soo Kim, Duk-Yeon Cho, Palanivel Ganesan, Dong-Kug Choi
Cognitive impairment and behavioral disparities are the distinctive baseline features to investigate in most animal models of neurodegenerative disease. However, neuronal complications are multifactorial and demand a suitable animal model to investigate their underlying basal mechanisms. By contrast, the numerous existing neurodegenerative studies have utilized various animal strains, leading to factual disparity. Choosing an optimal mouse strain for preliminary assessment of neuronal complications is therefore imperative...
August 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28780865/thermal-oxidation-degradation-of-2-2-4-4-tetrabromodiphenyl-ether-over-li%C3%AE-tiox-micro-nanostructures-with-the-dozens-of-oxidative-product-analysis-and-reaction-mechanism
#13
Qianqian Li, Guijin Su, Minghui Zheng, Mengjing Wang, Yalu Liu, Fang Luo, Yangyang Gu, Rong Jin
Flower-like LiαTiOx micro/nanostructures were successfully synthesized to degrade 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) at 250-350 °C. The pseudo-first-order kinetics rate constant of the reaction at 300 °C was in the range of 0.034-0.055 min-1. The activation energy was as low as 39.9-48.1 kJ/mol. The excellent performance attained over LiαTiOx was attributed to Li dopant having the electron-donating effect, which enhanced the oxygen specie mobility. The oxidative reaction was believed to be the dominant degradation pathway following Mars-van Krevelen mechanism, being accompanied by the weak hydrodebromination occurrence generating the trace mo- to tri-BDEs...
August 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28776669/hypomethylation-mediated-h19-overexpression-increases-the-risk-of-disease-evolution-through-the-association-with-bcr-abl-transcript-in-chronic-myeloid-leukemia
#14
Jing-Dong Zhou, Jiang Lin, Ting-Juan Zhang, Ji-Chun Ma, Xi-Xi Li, Xiang-Mei Wen, Hong Guo, Zi-Jun Xu, Zhao-Qun Deng, Wei Zhang, Jun Qian
Previous study has revealed that H19 expression is required for efficient tumor growth induced by BCR-ABL in chronic myeloid leukemia (CML). Herein, we further determined H19 expression and its clinical implication in patients with CML. H19 expression and methylation were detected by real-time quantitative PCR and real-time quantitative methylation-specific PCR, and then clinical implication of H19 expression was further analyzed. H19 expression was significantly up-regulated in CML patients (P < 0.001)...
August 4, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28776445/inhibition-of-dengue-virus-replication-by-novel-inhibitors-of-rna-dependent-rna-polymerase-and-protease-activities
#15
Sveva Pelliccia, Yu-Hsuan Wu, Antonio Coluccia, Giuseppe La Regina, Chin-Kai Tseng, Valeria Famiglini, Domiziana Masci, John Hiscott, Jin-Ching Lee, Romano Silvestri
Dengue virus (DENV) is the leading mosquito-transmitted viral infection in the world. With more than 390 million new infections annually, and up to 1 million clinical cases with severe disease manifestations, there continues to be a need to develop new antiviral agents against dengue infection. In addition, there is no approved anti-DENV agents for treating DENV-infected patients. In the present study, we identified new compounds with anti-DENV replication activity by targeting viral replication enzymes - NS5, RNA-dependent RNA polymerase (RdRp) and NS3 protease, using cell-based reporter assay...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28775241/comparative-study-of-macrophages-in-naked-mole-rats-and-icr-mice
#16
Jishuai Cheng, Zheng Yuan, Wenjing Yang, Chang Xu, Wei Cong, Lifang Lin, Shanmin Zhao, Wei Sun, Xiaosong Bai, Shufang Cui
The domestic and foreign scholars have studied naked mole rats more focused on the respect such as its long life, resistant to low oxygen, little spontaneous tumor, but the study of the immune system is little. In this study, we compared the anatomy and tissue morphology of NMR and ICR mouse spleens and found that the gross appearance of the NNMR spleen differed from ICR. There were more macrophages in NNMR spleens than in ICR spleens. Furthermore, we focused on the differences of macrophages. We compared their phagocytic capabilities and the data showed that NNMR macrophages are more phagocytic than ICR mouse macrophages...
July 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28772726/effects-of-heat-treated-wood-particles-on-the-physico-mechanical-properties-and-extended-creep-behavior-of-wood-recycled-hdpe-composites-using-the-time-temperature-superposition-principle
#17
Teng-Chun Yang, Yi-Chi Chien, Tung-Lin Wu, Ke-Chang Hung, Jyh-Horng Wu
This study investigated the effectiveness of heat-treated wood particles for improving the physico-mechanical properties and creep performance of wood/recycled-HDPE composites. The results reveal that the composites with heat-treated wood particles had significantly decreased moisture content, water absorption, and thickness swelling, while no improvements of the flexural properties or the wood screw holding strength were observed, except for the internal bond strength. Additionally, creep tests were conducted at a series of elevated temperatures using the time-temperature superposition principle (TTSP), and the TTSP-predicted creep compliance curves fit well with the experimental data...
March 30, 2017: Materials
https://www.readbyqxmd.com/read/28772236/a-novel-glucagon-like-peptide-1-glucagon-receptor-dual-agonist-exhibits-weight-lowering-and-diabetes-protective-effects
#18
Jie Zhou, Xingguang Cai, Xun Huang, Yuxuan Dai, Lidan Sun, Bo Zhang, Bo Yang, Haiyan Lin, Wenlong Huang, Hai Qian
Glucagon has plenty of effects via a specific glucagon receptor(GCGR) like elevating the blood glucose, improving fatty acids metabolism, energy expenditure and increasing lipolysis in adipose tissue. The most important role of glucagon is to regulate the blood glucose, but the emergent possibilities of hyperglycaemia is exist. Glucagon could also slightly activate glucagon-like peptide-1 receptor(GLP-1R), which lead to blood glucose lowering effect. This study aims to erase the likelihood of hyperglycaemia and to remain the inherent catabolic effects through improving GLP-1R activation and deteriorating GCGR activation so as to lower the bodyweight and show diabetes-protective effects...
July 24, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28763951/sulfites-and-the-wine-metabolome
#19
Chloé Roullier-Gall, Daniel Hemmler, Michael Gonsior, Yan Li, Maria Nikolantonaki, Alissa Aron, Christian Coelho, Régis D Gougeon, Philippe Schmitt-Kopplin
In a context of societal concern about food preservation, the reduction of sulfite input plays a major role in the wine industry. To improve the understanding of the chemistry involved in the SO2 protection, a series of bottle aged Chardonnay wines made from the same must, but with different concentrations of SO2 added at pressing were analyzed by ultrahigh resolution mass spectrometry (FT-ICR-MS) and excitation emission matrix fluorescence (EEMF). Metabolic fingerprints from FT-ICR-MS data could discriminate wines according to the added concentration to the must but they also revealed chemistry-related differences according to the type of stopper, providing a wine metabolomics picture of the impact of distinct stopping strategies...
December 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28760723/impact-of-residual-syntax-score-on-clinical-outcomes-after-incomplete-revascularization-percutaneous-coronary-intervention-a-large-single-centre-study
#20
Ying Song, Zhan Gao, Xiaofang Tang, Ping Jiang, Jingjing Xu, Yi Yao, Jianxin Li, Xueyan Zhao, Shubin Qiao, Yuejin Yang, Runlin Gao, Bo Xu, Jinqing Yuan
AIMS: This study assessed the prognostic capacity of residual SYNTAX score (rSS) in a large cohort of patients undergoing percutaneous coronary intervention(PCI) in clinical practice. METHODS AND RESULTS: 10,344 consecutive patients were prospectively enrolled. Complete revascularization (CR; rSS=0), reasonable incomplete revascularization (RICR; 0 < rSS ≤ 8), and ICR (rSS > 8) were achieved in 5375 (51.9%), 3401 (32.9%), and 1568 (15.2%) patients. During 2-year follow-up, ICR patients had the highest incidences of major adverse cardiovascular and cerebrovascular events (MACCE; 20...
August 1, 2017: EuroIntervention
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