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https://www.readbyqxmd.com/read/27912874/the-anxiolytic-effect-of-essential-oil-of-cananga-odorata-exposure-on-mice-and-determination-of-its-major-active-constituents
#1
Nan Zhang, Lei Zhang, Linyin Feng, Lei Yao
BACKGROUND: Essential oil from Cananga odorata (ylang-ylang essential oil, YYO) is usually used in reducing blood pressure, improving cognitive functioning in aromatherapy in human. Few reports showed its effect on anxiety behaviors. HYPOTHESIS/PURPOSE: To investigate the anxiolytic effects of YYO exposure on anxiety animal models, determine the major active constituents and investigate the change of neurotransmitters after odor exposure. STUDY DESIGN AND METHODS: ICR mice were subjected to three anxiety models including open field, elevated plus maze and light-dark box tests after acute and chronic YYO exposure...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27910183/on-the-origin-of-the-remarkably-variable-reactivities-of-alceox-x-2-4-towards-methane-as-a-function-of-oxygen-content
#2
Shaodong Zhou, Jilai Li, Maria Schlangen, Helmut Schwarz
The thermal gas-phase reactions of the closed-shell heteronuclear metal-oxide clusters [AlCeOx ](+) (x=2-4) with methane have been explored by FT-ICR mass spectrometry and high-level quantum-chemical calculation. Whereas [AlCeO2 ](+) and [AlCeO4 ](+) are inert towards methane under ambient conditions, [AlCeO3 ](+) spontaneously abstracts one hydrogen atom from methane. Mechanistic aspects have been addressed to reveal the reasons for the rather distinct reactivities of the [AlCeOx ](+) /CH4 couples, and the electronic origins of the unprecedented single hydrogen-atom abstraction from methane by closed-shell [AlCeO3 ](+) are discussed...
December 2, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27907885/complete-revascularization-versus-culprit-only-revascularization-in-st-segment-elevation-myocardial-infarction-and-multivessel-disease-patients-undergoing-primary-percutaneous-coronary-intervention-a-meta-analysis-and-trial-sequential-analysis
#3
REVIEW
Chong-Hui Wang, Shu-Yang Zhang, Xiao-Feng Jin
The present study compared the outcomes of complete revascularization (CR) and culprit-only revascularization (COR) performed during primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease through a meta-analysis in order to determine which strategy is more appropriate. Published randomized controlled trials (RCTs) were retrieved from the PubMed, EMBASE, and CENTRAL databases. Eight RCTs with 2060 patients were selected (1080 patients underwent CR [immediate (ICR) or staged (SCR)] and 980 patients underwent COR)...
November 10, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27904491/intravenous-transplantation-of-mouse-embryonic-stem-cells-attenuates-demyelination-in-an-icr-outbred-mouse-model-of-demyelinating-diseases
#4
Kidsadagon Pringproa, Anucha Sathanawongs, Chananthida Khamphilai, Sarocha Sukkarinprom, Apichart Oranratnachai
Induction of demyelination in the central nervous system (CNS) of experimental mice using cuprizone is widely used as an animal model for studying the pathogenesis and treatment of demyelination. However, different mouse strains used result in different pathological outcomes. Moreover, because current medicinal treatments are not always effective in multiple sclerosis patients, so the study of exogenous cell transplantation in an animal model is of great importance. The aims of the present study were to establish an alternative ICR outbred mouse model for studying demyelination and to evaluate the effects of intravenous cell transplantation in the present developed mouse model...
October 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/27901122/parental-and-sexual-conflicts-over-the-peg3-imprinted-domain
#5
Hongzhi He, Bambarendage P U Perera, An Ye, Joomyeong Kim
In the current study, the imprinting control region of the mouse Peg3 domain was deleted to test its functional impact on animal growth and survival. The paternal transmission of the deletion resulted in complete abolition of the transcription of two paternally expressed genes, Peg3 and Usp29, causing the reduced body weight of the pups. In contrast, the maternal transmission resulted in the unexpected transcriptional up-regulation of the remaining paternal allele of both Peg3 and Usp29, causing the increased body weight and survival rates...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27900259/dietary-fat-and-gut-microbiota-interactions-determine-diet-induced-obesity-in-mice
#6
Raphaela Kübeck, Catalina Bonet-Ripoll, Christina Hoffmann, Alesia Walker, Veronika Maria Müller, Valentina Luise Schüppel, Ilias Lagkouvardos, Birgit Scholz, Karl-Heinz Engel, Hannelore Daniel, Philippe Schmitt-Kopplin, Dirk Haller, Thomas Clavel, Martin Klingenspor
OBJECTIVE: Gut microbiota may promote positive energy balance; however, germfree mice can be either resistant or susceptible to diet-induced obesity (DIO) depending on the type of dietary intervention. We here sought to identify the dietary constituents that determine the susceptibility to body fat accretion in germfree (GF) mice. METHODS: GF and specific pathogen free (SPF) male C57BL/6N mice were fed high-fat diets either based on lard or palm oil for 4 wks. Mice were metabolically characterized at the end of the feeding trial...
December 2016: Molecular Metabolism
https://www.readbyqxmd.com/read/27899253/betulin-inhibited-cigarette-smoke-induced-copd-in-mice
#7
Ma Chunhua, Hongyan Long, Weina Zhu, Zheng Liu, Ruan Jie, Yajie Zhang, Yarui Wang
The purpose of the present study was to evaluate the protective effect of betulin (BE) on CS (cigarette smoke)-induced COPD in mice and explore its underlying mechanisms. 60 male ICR mice were randomly assigned to five groups: control group, model group, dexamethasone (2mg/kg) group, BE (20mg/kg) group and BE (40mg/kg) group. The COPD mice were induced by cigarette smoke exposure for 8 weeks. The result of H&E staining demonstrated that BE inhibited CS-induced pathological injury in lung tissue. Besides, BE could restore the activities of superoxide dismutase (SOD) in serum and in lung, catalase (CAT) in serum and reduce the content of malondialdehyde (MDA) in serum and in lung...
November 26, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27895382/non-invasive-measurement-of-melanin-derived-radicals-in-living-mouse-tail-using-x-band-epr
#8
Yukihiro Ogawa, Megumi Ueno, Emiko Sekine-Suzuki, Ikuo Nakanishi, Ken-Ichiro Matsumoto, Shingo Fujisaki
The aim of this experiment is to measure in vivo generation of melanin-derived radicals non-invasively, as a quantifiable index of radio-biological effect. Melanin-derived radicals in a living intact mouse tail tip were non-invasively measured in very simple way using an X-band electron paramagnetic resonance spectrometer. Colored mouse strains, C57BL/6NCr, BDF1, and C3H/He, have clear EPR signal corresponding to melanin-derived radicals in the tail tip; however, albino mouse strains, BALB/cCr, ddY, ICR, have no EPR signals...
November 2016: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/27889913/long-term-melatonin-treatment-delays-ovarian-aging
#9
Hiroshi Tamura, Mai Kawamoto, Shun Sato, Isao Tamura, Ryo Maekawa, Toshiaki Taketani, Hiromi Aasada, Eiichi Takaki, Akira Nakai, Russel J Reiter, Norihiro Sugino
Ovarian aging is characterized by gradual declines in oocyte quantity and quality. Melatonin is considered an anti-aging agent due to its cytoprotective actions as an antioxidant. The present study examined whether long-term melatonin treatment would delay ovarian aging in mice. Female ICR mice (10 weeks old) were given melatonin-containing water (100 μg/ml; melatonin) or water only until 43 weeks of age. Their oocytes were recovered from the oviduct, and in vitro fertilization was performed. The ovaries were used for a histological analysis of the number of follicles...
November 27, 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/27878498/stimulation-of-diethylnitrosamine-metabolism-reduces-its-general-toxic-and-hepatocarcinogenic-effects
#10
S I Il'nitskaya, V I Kaledin, L A Bogdanova, T S Morozkova, V I Kapustina, M L Perepechaeva, A Yu Grishanova
The general toxic and hepatocarcinogenic effects of diethylnitrosamine after stimulation of its metabolism with 1,4-bis[2-(3,5-dichloropyridyloxy)]-benzene (TCPOBOP) were studied. The hydroxylating activity of liver microsomes of C57Bl/6Mv mice towards p-nitrophenol increased more than 4-fold 3 days after injection of TCPOBOP. Injection of diethylnitrosamine 3 days after TCPOBOP caused a lesser body weight loss and decrease of food consumption in C57Bl/6Mv mice than in response to diethylnitrosamine without preinduction...
November 23, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27878246/luteolin-protects-mice-from-severe-acute-pancreatitis-by-exerting-ho-1-mediated-anti-inflammatory-and-antioxidant-effects
#11
Jie Xiong, Kezhou Wang, Chunxiao Yuan, Rong Xing, Jianbo Ni, Guoyong Hu, Fengling Chen, Xingpeng Wang
Reseda odorata L. has long been used in traditional Asian medicine for the treatment of diseases associated with oxidative injury and acute inflammation, such as endotoxemia, acute lung injury, acute myocardial infarction and hepatitis. Luteolin, the main component of Reseda odorata L., which is also widely found in many natural herbs and vege-tables, has been shown to induce heme oxygenase-1 (HO-1) expression to exert anti-inflammatory and antioxidant effects. In this study, we aimed to examine the effects of luteolin on mice with severe acute pancreatitis (SAP), and to explore the underlying mechanisms...
November 22, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27876080/effect-of-testosterone-on-the-connexin37-of-sexual-mature-mouse-cumulus-oocyte-complex
#12
Yangyang Zhang, Yang Xu, Yanrong Kuai, Sheng Wang, Qing Xue, Jing Shang
BACKGROUND: Recent researches demonstrate that pre-treatment with androgen could increase retrieved oocytes number and clinical pregnancy rate in poor ovarian response (POR) patients. In view of gap junction intercellular communication (GJIC) is important for follicular growth, and androgen plays an important role in improving prognosis of POR patients, we speculate that androgen can increase the expression of connexin in follicle cells, and improve ovarian microenvironment, thus can promote ovarian response...
November 23, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27872647/antimalarial-properties-of-aqueous-crude-extracts-of-gynostemma-pentaphyllum-and-moringa-oleifera-leaves-in-combination-with-artesunate-in-plasmodium-berghei-infected-mice
#13
Voravuth Somsak, Preeyanuch Borkaew, Chokdee Klubsri, Kittiyaporn Dondee, Panatda Bootprom, Butsarat Saiphet
Due to the emergence and spread of malaria parasite with resistance to antimalarial drugs, discovery and development of new, safe, and affordable antimalarial are urgently needed. In this respect, medicinal plant extracts are targets to optimize antimalarial actions and restore efficacy of standard antimalarial drugs. The present study was aimed at determining the antimalarial activities of Gynostemma pentaphyllum and Moringa oleifera leaf extracts in combination with artesunate against Plasmodium berghei-infected mice...
2016: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27872613/rhamnolipids-produced-by-indigenous-acinetobacter-junii-from-petroleum-reservoir-and-its-potential-in-enhanced-oil-recovery
#14
Hao Dong, Wenjie Xia, Honghong Dong, Yuehui She, Panfeng Zhu, Kang Liang, Zhongzhi Zhang, Chuanfu Liang, Zhaozheng Song, Shanshan Sun, Guangqing Zhang
Biosurfactant producers are crucial for incremental oil production in microbial enhanced oil recovery (MEOR) processes. The isolation of biosurfactant-producing bacteria from oil reservoirs is important because they are considered suitable for the extreme conditions of the reservoir. In this work, a novel biosurfactant-producing strain Acinetobacter junii BD was isolated from a reservoir to reduce surface tension and emulsify crude oil. The biosurfactants produced by the strain were purified and then identified via electrospray ionization-Fourier transform ion cyclotron resonance mass spectrometry (ESI FT-ICR-MS)...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27871610/solid-phase-extraction-stepwise-elution-spe-se-procedure-for-isolation-of-dissolved-organic-matter-prior-to-esi-ft-icr-ms-analysis
#15
Jitao Lv, Shuzhen Zhang, Lei Luo, Dong Cao
Characterization of dissolved organic matter (DOM) at the molecular level will greatly improve our understanding of its bio-geochemical role in controlling the fate of contaminants in the environment, and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) is the most powerful analytical technique for this purpose. Before FT-ICR-MS analysis, isolation, desalination and concentration of DOM are necessary, and solid-phase extraction (SPE) is the most widely applied pretreatment procedure. However, some molecular information is lost using conventional SPE methods...
December 15, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27864358/effects-of-the-histone-deacetylase-inhibitor-scriptaid-on-the-developmental-competence-of-mouse-embryos-generated-through-round-spermatid-injection
#16
Pengcheng Kong, Mingru Yin, Dongbao Chen, Shangang Li, Yao Li, Fengying Xing, Manxi Jiang, Zhenfu Fang, Qifeng Lyu, Xuejin Chen
STUDY QUESTION: Can the histone deacetylase inhibitor Scriptaid improve the efficiency of the development of round spermatid injection (ROSI)-fertilized embryos in a mouse model? SUMMARY ANSWER: Treatment of ROSI mouse zygotes with Scriptaid increased the expression levels of several development-related genes at the blastocyst stage, resulting in more efficient in vitro development of the blastocyst and an increased birth rate of ROSI-derived embryos. WHAT IS KNOWN ALREADY: The full-term development of embryos derived through ROSI is significantly lower than that following ICSI in humans and other species...
November 17, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27856301/sulfur-fumigation-reducing-systemic-exposure-of-ginsenosides-and-weakening-immunomodulatory-activity-of-ginseng
#17
Bin Ma, Winnie Lai Ting Kan, He Zhu, Song-Lin Li, Ge Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Ginseng (Ginseng Radix et Rhizoma) is used worldwide for its miracle tonic effects, especially for its immunomodulatory activities. Sulfur fumigation, a fast and convenient method to prevent pesticidal and bacterial contamination in the food industry, has been recently employed during post-harvest processing of ginseng. Our previous studies demonstrated that sulfur fumigation significantly altered the chemical profile of the bioactive ingredients in ginseng...
November 15, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27853331/effects-of-platelet-rich-plasma-platelet-rich-fibrin-with-and-without-stromal-cell-derived-factor-1-on-repairing-full-thickness-cartilage-defects-in-knees-of-rabbits
#18
Soghra Bahmanpour, Maryam Ghasemi, Mohsen Sadeghi-Naini, Iraj Ragerdi Kashani
BACKGROUND: The purpose of this study was to create biomaterial scaffolds like platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) containing stromal cell-derived factor-1 (SDF1) as a chemokine to induce hyaline cartilage regeneration of rabbit knee in a full thickness defect. METHODS: We created a full thickness defect in the trochlear groove of thirty-six bilateral knees of eighteen mature male rabbits. The knees were randomly divided into six groups (group I: untreated control, group II: PRP, group III: PRF, group IV: Gelatin+SDF1, group V: PRP+SDF1, and group VI: PRF+SDF1)...
November 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27847384/parathyroid-hormone-induced-bone-marrow-mesenchymal-stem-cell-chondrogenic-differentiation-and-its-repair-of-articular-cartilage-injury-in-rabbits
#19
Yushu Chen, Yi Chen, Shujiang Zhang, Xiufan Du, Bo Bai
BACKGROUND We explored the effect of parathyroid hormone (PTH)-induced bone marrow stem cells (BMSCs) complexed with fibrin glue (FG) in the repair of articular cartilage injury in rabbits. MATERIAL AND METHODS Forty-eight rabbits randomized into four groups were subjected to articular surgery (cartilage loss). The PTH and non-PTH intervention groups included transplantation with PTH/BMSC/FG xenogeneic and BMSC/FG xenogeneic complexes, respectively, into the injured area. The injured group contained no transplant while the control group comprised rabbits without any articular injury...
November 16, 2016: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/27847245/celastrol-inhibits-dengue-virus-replication-via-up-regulating-type-i-interferon-and-downstream-interferon-stimulated-responses
#20
Jung-Sheng Yu, Chin-Kai Tseng, Chun-Kuang Lin, Yao-Chin Hsu, Yu-Hsuan Wu, Ching-Liang Hsieh, Jin-Ching Lee
ETHNOPHARMACOLOGICAL RELEVANCE AND AIM OF THE STUDY: Tripterygium wilfordii (lei gong teng; Thunder of God Vine), a member of the Celastraceae family, is a medicinal plant used to treat a range of illnesses. Celastrol is a quinone methide triterpene and the most abundant bioactive constituent isolated from the root extracts of T. wilfordii. Previous studies have shown that celastrol exhibits antiviral activity against HIV and SARS-CoV. To date, no investigations of the anti-DENV activity of celastrol have been reported...
November 12, 2016: Antiviral Research
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