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https://www.readbyqxmd.com/read/29166710/-effects-of-hydrogen-on-the-lung-damage-of-mice-at-early-stage-of-severe-burn
#1
C Qin, Y X Bian, T T Feng, J H Zhang, Y H Yu
Objective: To investigate the effects of hydrogen on the lung damage of mice at early stage of severe burn. Methods: One hundred and sixty ICR mice were divided into sham injury, hydrogen, pure burn, and burn+ hydrogen groups according to the random number table, with 40 mice in each group. Mice in pure burn group and burn+ hydrogen group were inflicted with 40% total body surface area full-thickness scald (hereafter referred to as burn) on the back, while mice in sham injury group and hydrogen group were sham injured...
November 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/29164462/ameliorative-effect-of-the-anticancer-agent-salinomycin-on-cadmium-induced-hepatotoxicity-and-renal-dysfunction-in-mice
#2
Kalina Kamenova, Yordanka Gluhcheva, Ivelin Vladov, Silviya Stoykova, Juliana Ivanova
This study presents experimental data on the effects of the tetraethylammonium salt of salinomycinic acid (Sal) on Cd-induced hepatotoxicity and renal dysfunction in Cd-treated mice compared to those of meso-2,3-dimercaptosuccinic acid (DMSA). Forty 60-day-old male ICR mice were randomized into five groups: control group (untreated mice), Cd group (Cd(II) acetate 20 mg/kg body weight provided orally once per day for 14 days), Cd + DMSA group (exposed to Cd(II) acetate as the Cd-exposed group followed by DMSA 20 mg/kg body weight provided orally once per day for 14 days), and Cd + Sal group (exposed to Cd(II) acetate as the Cd-exposed group followed by Sal 20 mg/kg body weight once per day for 14 days)...
November 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29162079/examination-of-concomitant-glenohumeral-pathologies-in-patients-treated-arthroscopically-for-calcific-tendinitis-of-the-shoulder-and-implications-for-routine-diagnostic-joint-exploration
#3
Gernot Lang, Kaywan Izadpanah, Eva Johanna Kubosch, Dirk Maier, Norbert Südkamp, Peter Ogon
BACKGROUND: Glenohumeral exploration is routinely performed during arthroscopic removal of rotator cuff calcifications in patients with calcific tendinitis of the shoulder (CTS). However, evidence on the prevalence of intraarticular co-pathologies is lacking and the benefit of glenohumeral exploration remains elusive. The aim of the present study was to assess and quantify intraoperative pathologies during arthroscopic removal of rotator cuff calcifications in order to determine whether standardized diagnostic glenohumeral exploration appears justified in CTS patients...
November 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29161095/resection-induced-leveling-of-elevated-plug-cartilage-in-osteochondral-autologous-transplantation-of-the-knee-achieves-acceptable-clinical-results
#4
Kohei Nishitani, Yasuaki Nakagawa, Shinichiro Nakamura, Shogo Mukai, Shinichi Kuriyama, Shuichi Matsuda
BACKGROUND: Plug protuberance occasionally occurs in osteochondral autologous transplantation (OAT). The incongruity of plugs results in poor clinical outcomes, especially in cases of protuberance. However, a surgical procedure to deal with this problem has not been reported. Purpose/Hypothesis: The purpose was to evaluate the efficacy and safety of cartilage resection of elevated plugs, with the hypothesis that patients whose elevated plugs were resected and leveled would achieve clinical outcomes equivalent to those of patients with flush plugs...
November 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29157910/vigilin-interacts-with-ctcf-and-is-involved-in-the-maintenance-of-imprinting-of-igf2-through-a-novel-rna-mediated-mechanism
#5
Xiaoqin Yu, Qiuying Liu, Jinyang He, Yuan Huang, Lei Jiang, Xiaoyan Xie, Ji Liu, Lihong Chen, Ling Wei, Yang Qin
Accumulating evidence has revealed the imprinting of insulin-like growth factor-2 gene (IGF2) is maintained by binding of CCCTC binding factor (CTCF) to the unmethylated imprinting control region (ICR) between IGF2 and H19 genes. We have previously reported that high-density lipoprotein binding protein (HDLBP/vigilin), a multiKH-domain protein, interacts with CTCF and coexists with it at several CTCF-binding sites on the ICR to regulate general gene expression of IGF2. However, the impact of the interaction on imprinting of IGF2 remains unclear...
November 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29157831/vitis-labruscana-leaf-extract-ameliorates-scopolamine-induced-impairments-with-activation-of-akt-erk-and-creb-in-mice
#6
Ramesh Pariyar, Chi-Su Yoon, Thida Svay, Dae-Sung Kim, Hyoung-Kwon Cho, Sung Yeon Kim, Hyuncheol Oh, Youn-Chul Kim, Jaehyo Kim, Ho-Sub Lee, Jungwon Seo
BACKGROUND: Grapes are among the most widely consumed plants and are used as a folk medicine. Vitis species have been traditionally used as anti-inflammatory, analgesic, and memory-enhancing agents, but, their biological activities of discarded grape leaves are not completely understood. PURPOSE: We investigated the effects of alcoholic aqueous leaf extract of Vitis labruscana (LEVL) in a mouse model of memory impairment and tried to ascertain its mechanism. We also evaluated its effects in SH-SY5Y cells...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29156980/platelet-rich-plasma-and-hyaluronic-acid-are-not-synergistic-when-used-as-biological-adjuncts-with-autologous-osteochondral-transplantation
#7
Niall A Smyth, Keir A Ross, Amgad M Haleem, Charles P Hannon, Christopher D Murawski, Huong T Do, John G Kennedy
INTRODUCTION: Autologous osteochondral transplantation (AOT) is a treatment for osteochondral lesions with known concerns, including histological degradation of the graft and poor cartilage integration. Platelet-rich plasma (PRP) and hyaluronic acid (HA) have been described has having the potential to improve results. The aim of this study was to evaluate the effect of PRP and HA on AOT in a rabbit model. METHODS: Thirty-six rabbits underwent bilateral knee AOT treated with either the biological adjunct (PRP, n = 12; HA, n = 12; PRP + HA, n = 12) or saline (control)...
January 1, 2017: Cartilage
https://www.readbyqxmd.com/read/29155538/aetiological-histopathological-clinical-diagnostic-and-therapeutical-features-of-idiopathic-cervical-resorption
#8
Virginia Robles Gijón, Cristina Lucena Martín, Rosa Mª Pulgar Encinas, José Manuel Navajas
Root resorption is the loss of hard dental tissue as a result of odontoclastic action involving vital and pulpless teeth. Cervical root resorption (CRR) is a type of external resorption which usually occurs immediately below the epithelial attachment of the tooth in the cervical region. The idiopathic cervical resorption (ICR) refers to a clinical situation in which all other causes, whether local or systemic, have been ruled out as the origin of the disease. The early stage is asymptomatic and might be diagnosed by a routine radiograph or a clinical examination...
December 2016: Dental Update
https://www.readbyqxmd.com/read/29154736/lactobacilli-fermented-cow-s-milk-attenuated-lipopolysaccharide-induced-neuroinflammation-and-memory-impairment-in-vitro-and-in-vivo
#9
Nurul Huda Musa, Vasudevan Mani, Siong Meng Lim, Sharmili Vidyadaran, Abu Bakar Abdul Majeed, Kalavathy Ramasamy
Nutritional interventions are now recommended as strategies to delay Alzheimer's disease (AD) progression. The present study evaluated the neuroprotective effect (anti-inflammation) of lactic acid bacteria (either Lactobacillus fermentum LAB9 or L. casei LABPC) fermented cow's milk (CM) against lipopolysaccharide (LPS)-activated microglial BV2 cells in vitro. The ability of CM-LAB in attenuating memory deficit in LPS-induced mice was also investigated. ICR mice were orally administered with CM-LAB for 28 d before induction of neuroinflammation by LPS...
November 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/29148594/metabolic-study-of-paeoniflorin-and-total-paeony-glucosides-from-paeoniae-radix-rubra-in-rats-by-high-performance-liquid-chromatography-coupled-with-sequential-mass-spectrometry-uplc-esi-ms-n
#10
Lijun Zhu, Shanshan Sun, Yanxi Hu, Yufeng Liu
A clear understanding of the metabolism of Traditional Chinese Medicine (TCM) is extremely important in their rational clinical application and effective material foundation research. A novel and reliable strategy was performed to find more metabolites of paeoniflorin, determine the metabolites of total paeony glucosides (TPG) by means of determining those metabolites of paeoniflorin, and compare the metabolism differences between paeoniflorin and TPG by intragastric administration. This strategy was characterized as follows: firstly, the rats were divided into two groups (the paeoniflorin group and the TPG group) to find different metabolism mechanism between paeoniflorin and TPG; secondly, UPLC-FT-ICR MS and UPLC-Q-TOF MS(2) were applied to obtain accurate molecular weight and structural information respectively; thirdly, the metabolites were tentatively identified by a combination of data-processing methods including mass defect screening, characteristic neutral loss screening and product ion screening; finally, a comparative study was employed in the metabolism of paeoniflorin and TPG...
November 17, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29145065/gestational-differences-in-murine-placenta-glycolytic-metabolism-and-pregnancy-parameters
#11
Renee E Albers, Christopher A Waker, Chanel Keoni, Melissa R Kaufman, Michael A Bottomley, Sarah Min, David R Natale, Thomas L Brown
The placenta is a complex and essential organ composed largely of fetal-derived cells, including several different trophoblast subtypes that work in unison to support nutrient transport to the fetus during pregnancy. Abnormal placental development can lead to pregnancy-associated disorders that often involve metabolic dysfunction. The scope of dysregulated metabolism during placental development may not be fully representative of the in vivo state in defined culture systems, such as cell lines or isolated primary cells...
November 4, 2017: Theriogenology
https://www.readbyqxmd.com/read/29141007/escitalopram-and-nht-normalized-stress-induced-anhedonia-and-molecular-neuroadaptations-in-a-mouse-model-of-depression
#12
Or Burstein, Motty Franko, Eyal Gale, Assaf Handelsman, Segev Barak, Shai Motsan, Alon Shamir, Roni Toledano, Omri Simhon, Yafit Hirshler, Gang Chen, Ravid Doron
Anhedonia is defined as a diminished ability to obtain pleasure from otherwise positive stimuli. Anxiety and mood disorders have been previously associated with dysregulation of the reward system, with anhedonia as a core element of major depressive disorder (MDD). The aim of the present study was to investigate whether stress-induced anhedonia could be prevented by treatments with escitalopram or novel herbal treatment (NHT) in an animal model of depression. Unpredictable chronic mild stress (UCMS) was administered for 4 weeks on ICR outbred mice...
2017: PloS One
https://www.readbyqxmd.com/read/29135710/adjustment-of-intrastromal-corneal-ring-segments-after-unsuccessful-implantation-in-keratoconic-eyes
#13
Tiago Monteiro, José Ferreira Mendes, Fernando Faria-Correia, Nuno Franqueira, David Madrid-Costa, José F Alfonso
PURPOSE: To evaluate visual, refractive, and corneal topography outcomes in eyes with keratoconus that have undergone exchange/adjustment surgery with a new intrastromal corneal ring segment (ICRS) combination after unsuccessful visual and/or refractive outcomes after primary ICRS surgery. METHODS: A retrospective nonrandomized case series was conducted including consecutive eyes of patients with keratoconus that underwent ICRS adjustment after an unsuccessful visual outcome...
November 13, 2017: Cornea
https://www.readbyqxmd.com/read/29133762/rare-earth-nanoparticle-induced-cytotoxicity-on-spatial-cognition-memory-of-mouse-brain
#14
Cai-Hou Lin, Gui-Fen Liu, Jing Chen, Yan Chen, Ru-Hui Lin, Hong-Xing He, Jian-Ping Chen
BACKGROUND: Luminescent rare-earth-based nanoparticles have been increasingly used in nanomedicine due to their excellent physicochemical properties, such as biomedical imaging agents, drug carriers, and biomarkers. However, biological safety of the rare-earth-based nanomedicine is of great significance for future development in practical applications. In particular, biological effects of rare-earth nanoparticles on human's central nervous system are still unclear. This study aimed to investigate the potential toxicity of rare-earth nanoparticles in nervous system function in the case of continuous exposure...
November 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29132299/chronic-administration-of-parecoxib-exerts-anxiolytic-like-and-memory-enhancing-effects-and-modulates-synaptophysin-expression-in-mice
#15
Bo Wang, Xin Jin, Xin Kuang, Shaowen Tian
BACKGROUND: Previous studies have shown that cyclooxygenase-2, a key enzyme that converts arachidonic acid to prostaglandins, is involved in anxiety and cognitive processes, but few studies have investigated the effects of chronic administration of cyclooxygenase-2 inhibitors on anxiety, learning and memory under normal physiological conditions. The aim of the study was to investigate the effects of chronic administration of parecoxib, a cyclooxygenase-2 inhibitor, on anxiety behavior and memory performance under normal physiological conditions and to explore the possible neural mechanism underlying parecoxib-mediated effects...
November 13, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/29132111/characterization-of-global-metabolic-profile-of-rhodiola-crenulata-after-oral-administration-in-rat-plasma-urine-bile-and-feces-based-on-uhplc-ft-icr-ms
#16
Yanting Li, Yangyang Zhao, Xintong Li, Tianfeng Liu, Xiwei Jiang, Fei Han
Rhodiola crenulata has been widely used as a health food, antifatigue and antidepressant in China and many other countries for centuries. However, to date the metabolism of it in vivo still remains unclear. In this study, UHPLC-FT-ICR MS was used to analyze the major components and their metabolites in rats after oral administration of Rhodiola crenulata for the first time. A total of 179 constituents, including 37 prototype compounds and 142 metabolites (89 phase I metabolites and 53 phase II metabolites) were tentatively identified...
November 10, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29122098/contribution-of-3cd-region-to-the-virulence-of-enterovirus-71
#17
Jing Li, Feng Gao, Shu Bin Hao, Dong Cheng, Wen Qiang Zhang, Bin Lin, Li Zhao, Xue Jie Yu, Zhi Yu Wang, Hong Ling Wen
Enterovirus 71 is a neuroinvasive virus that is associated with severe neurological complications. We had earlier suggested that the replication capacity of a severe strain was higher than that of a mild strain. The recombinant 3CRV and 3CDRV virus strains were successfully rescued in our previous study. In the present study, we found no difference in virulence between 3CRV and severe strains. However, the capacity of replication and to cause cell injury of 3CDRV strain decreased in vitro, especially at 39...
October 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29120710/femtosecond-laser-implantation-of%C3%A2-a%C3%A2-340-degree-intrastromal-corneal-ring%C3%A2-segment-in-keratoconus-short-term%C3%A2-outcomes
#18
Mohammad Mehdi Sadoughi, Bahram Einollahi, Amir Reza Veisi, Mohammad Zare, Mohammad Reza Sedaghat, Danial Roshandel, Neda Einollahi, Javad Rezaei
PURPOSE: To evaluate the short-term outcomes of femtosecond laser-assisted implantation of a 340-degree intracorneal ring (ICR) (Keraring) in patients with keratoconus. SETTING: Four centers in Iran. DESIGN: Prospective case series. METHODS: All cases had implantation of the 340-degree ICR after tunnel creation with a femtosecond laser. The uncorrected (UDVA) and corrected (CDVA) distance visual acuities, sphere, cylinder, manifest refraction spherical equivalent (MRSE), mean keratometry (K), steep K, and flat K were evaluated preoperatively and 1, 3, and 6 months postoperatively...
October 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29120613/formularity-software-for-automated-formula-assignment-of-natural-and-other-organic-matter-from-ultrahigh-resolution-mass-spectra
#19
Nikola Tolić, Yina Liu, Andrey Liyu, Yufeng Shen, Malak M Tfaily, Elizabeth B Kujawinski, Krista Longnecker, Li-Jung Kuo, Errol W Robinson, Ljiljana Paša-Tolić, Nancy J Hess
Ultrahigh resolution mass spectrometry, such as Fourier transform ion cyclotron resonance mass spectrometry (FT ICR MS), can resolve thousands of molecular ions in complex organic matrices. A Compound Identification Algorithm (CIA) was previously developed for automated elemental formula assignment for natural organic matter (NOM). In this work, we describe software Formularity with a user-friendly interface for CIA function and newly developed search function Isotopic Pattern Algorithm (IPA). While CIA assigns elemental formulas for compounds containing C, H, O, N, S, and P, IPA is capable of assigning formulas for compounds containing other elements...
November 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29119518/cyclotron-phase-coherent-ion-spatial-dispersion-in-a-non-quadratic-trapping-potential-is-responsible-for-ft-icr-ms-at-the-cyclotron-frequency
#20
Konstantin O Nagornov, Anton N Kozhinov, Yury O Tsybin
Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) at the cyclotron frequency instead of the reduced cyclotron frequency has been experimentally demonstrated using narrow aperture detection electrode (NADEL) ICR cells. Here, based on the results of SIMION simulations, we provide the initial mechanistic insights into the cyclotron frequency regime generation in FT-ICR MS. The reason for cyclotron frequency regime is found to be a new type of a collective motion of ions with a certain dispersion in the initial characteristics, such as pre-excitation ion velocities, in a highly non-quadratic trapping potential as realized in NADEL ICR cells...
November 8, 2017: Journal of the American Society for Mass Spectrometry
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