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https://www.readbyqxmd.com/read/28087074/quantifying-loading-toxic-concentrations-and-systemic-persistence-of-chloride-in-a-contemporary-mixed-land-use-watershed-using-an-experimental-watershed-approach
#1
J A Hubbart, E Kellner, L W Hooper, S Zeiger
A nested-scale experimental watershed study was implemented to quantify loading and persistence of chloride in an urbanizing, mixed-land-use watershed. A Midwest USA (Missouri) watershed was partitioned into five sub-basins with contrasting dominant land use. Streamwater was tested for chloride concentration four days per week from October 2009 through May 2014 at each site. Monitoring sites included co-located gauging and climate stations recording variables at 30-minute intervals. Results indicate significant (p<0...
January 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28086831/evaluation-of-the-cytotoxicity-of-the-bithionol-cisplatin-combination-in-a-panel-of-human-ovarian-cancer-cell-lines
#2
Vijayalakshmi N Ayyagari, Tsung-Han Jeff Hsieh, Paula L Diaz-Sylvester, Laurent Brard
BACKGROUND: Combination drug therapy appears a promising approach to overcome drug resistance and reduce drug-related toxicities in ovarian cancer treatments. In this in vitro study, we evaluated the antitumor efficacy of cisplatin in combination with Bithionol (BT) against a panel of ovarian cancer cell lines with special focus on cisplatin-sensitive and cisplatin-resistant cell lines. The primary objectives of this study are to determine the nature of the interactions between BT and cisplatin and to understand the mechanism(s) of action of BT-cisplatin combination...
January 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28076299/association-between-plasma-proanp-and-hyperuricemia-in-chinese-han-women-a-cross-sectional-study
#3
Zhengbao Zhu, Qiu Zhang, Hao Peng, Chongke Zhong, Yan Liu, Xinfeng Huangfu, Yunfan Tian, Xiangqin Chao, Jianhua Jin, Yonghong Zhang
BACKGROUND: Association between pro-atrial natriuretic peptide (proANP) and hyperuricemia has not yet been investigated in population. This study aimed to examine the association in Chinese Han women. METHODS: We measured plasma proANP, serum uric acid, and other traditional biomarkers in 1360 women older than 30 years residing in the Gusu district of Suzhou City. Association between plasma proANP and hyperuricemia was analyzed in women aged ≥45 years and those aged <45 years, respectively...
January 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28073987/neutrophil-lymphocyte-ratio-and-risk-of-atrial-fibrillation-after-thoracic-surgery
#4
Kevin J Walsh, Kay See Tan, Hao Zhang, David Amar
OBJECTIVES: Postoperative atrial fibrillation (POAF) occurs frequently in patients after noncardiac thoracic surgery and has been associated with increased morbidity and risk of stroke. Recent studies have shown conflicting results on the role of neutrophil-lymphocyte ratio (NLR) and its association with the development of POAF after cardiac surgery. Our goal was to determine whether an association exists between NLR and the incidence of POAF after non-cardiac thoracic surgery. METHODS: Using a database of 259 consecutive patients age 60 or older who had anatomic lung resection or oesophagectomy for oncologic resection, we compared preoperative, postanaesthesia care unit and postoperative day 1 NLR between patients who did and did not develop POAF during their hospitalization using Fisher's exact test or logistic regression...
January 10, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28073119/in-vitro-inhibition-of-human-cyp450s-1a2-2c9-3a4-5-2d6-and-2e1-by-grandisin
#5
Maísa Daniela Habenschus, Fernanda de Lima Moreira, Norberto Peporine Lopes, Anderson R M de Oliveira
Grandisin, a lignan isolated from many species of plants, such as Virola surinamensis, is a potential drug candidate due to its biological properties, highlighted by its antitumor and trypanocidal activities. In this study, the inhibitory effects of grandisin on the activities of human cytochrome P450 enzymes were investigated by using human liver microsomes. Results showed that grandisin is a competitive inhibitor of CYP2C9 and a competitive and mechanism-based inhibitor of CYP3A4/5. The apparent Ki value for CYP2C9 was 50...
January 10, 2017: Planta Medica
https://www.readbyqxmd.com/read/28060732/prognostic-impact-of-cd73-and-a2a-adenosine-receptor-expression-in-non-small-cell-lung-cancer
#6
Yusuke Inoue, Katsuhiro Yoshimura, Nobuya Kurabe, Tomoaki Kahyo, Akikazu Kawase, Masayuki Tanahashi, Hiroshi Ogawa, Naoki Inui, Kazuhito Funai, Kazuya Shinmura, Hiroshi Niwa, Takafumi Suda, Haruhiko Sugimura
In immune cells, CD73 dephosphorylates and converts extracellular AMP into adenosine, which binds the A2A adenosine receptor (A2AR). Blockade of this interaction, which induces an immunosuppressed niche in the tumor microenvironment, represents a potential novel treatment strategy. The clinical significance of CD73 and A2AR expression in non-small-cell lung cancer (NSCLC), however, has yet to be thoroughly investigated. Here we evaluated CD73 and A2AR protein expression levels using immunohistochemistry in tissue microarrays containing 642 resected NSCLC specimens...
January 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28059345/spectrum-regulation-for-mid-infrared-ultrafast-pulses-via-a-time-synchronization-aperiodically-poled-linbo-sub-3-sub
#7
Haizhe Zhong, Fen Qin, Jianlong Yang, Lifu Zhang, Changwen Xu, Ying Li, Dianyuan Fan
Restricted to temporal separation during the coupled-waves interaction, aperiodically quasi-phase-matching (QPM) nonlinear crystals are primarily implemented for prechirped pulses, showing limited applications in ultrafast temporal scale. Under the proposed time-synchronization framework, pump and signal waves travel with identical group-velocity, which permits sustaining energy transfer in long aperiodically poled LiNbO<sub>3</sub> crystals (APPLN) even with ultrafast pulse duration. With the help of this structure, adiabatic frequency conversion shows extra advantages compared with the common cases, which enables lower stretching ratio and smoother gain spectrum...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28049839/gas6-is-a-key-homeostatic-immunological-regulator-of-host-commensal-interactions-in-the-oral-mucosa
#8
Maria Nassar, Yaara Tabib, Tal Capucha, Gabriel Mizraji, Tsipora Nir, Meirav Pevsner-Fischer, Gili Zilberman-Schapira, Oded Heyman, Gabriel Nussbaum, Herve Bercovier, Asaf Wilensky, Eran Elinav, Tal Burstyn-Cohen, Avi-Hai Hovav
The oral epithelium contributes to innate immunity and oral mucosal homeostasis, which is critical for preventing local inflammation and the associated adverse systemic conditions. Nevertheless, the mechanisms by which the oral epithelium maintains homeostasis are poorly understood. Here, we studied the role of growth arrest specific 6 (GAS6), a ligand of the TYRO3-AXL-MERTK (TAM) receptor family, in regulating oral mucosal homeostasis. Expression of GAS6 was restricted to the outer layers of the oral epithelium...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28048627/tu-fg-209-03-exploring-the-maximum-count-rate-capabilities-of-photon-counting-arrays-based-on-polycrystalline-silicon
#9
A K Liang, M Koniczek, L E Antonuk, Y El-Mohri, Q Zhao
PURPOSE: Photon counting arrays (PCAs) offer several advantages over conventional, fluence-integrating x-ray imagers, such as improved contrast by means of energy windowing. For that reason, we are exploring the feasibility and performance of PCA pixel circuitry based on polycrystalline silicon. This material, unlike the crystalline silicon commonly used in photon counting detectors, lends itself toward the economic manufacture of radiation tolerant, monolithic large area (e.g., ∼43×43 cm2) devices...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042469/rational-design-of-a-water-soluble-lipid-compatible-fluorescent-probe-for-cu-i-with-sub-part-per-trillion-sensitivity
#10
M T Morgan, A McCallum, C J Fahrni
Fluorescence probes represent an attractive solution for the detection of the biologically important Cu(I) cation; however, achieving a bright, high-contrast response has been a challenging goal. Concluding from previous studies on pyrazoline-based fluorescent Cu(I) probes, the maximum attainable fluorescence contrast and quantum yield were limited due to several non-radiative deactivation mechanisms, including ternary complex formation, excited state protonation, and colloidal aggregation in aqueous solution...
February 2016: Chemical Science
https://www.readbyqxmd.com/read/28038415/foaming-and-adsorption-behavior-of-bovine-and-camel-proteins-mixed-layers-at-the-air-water-interface
#11
Roua Lajnaf, Laetitia Picart-Palmade, Hamadi Attia, Sylvie Marchesseau, M A Ayadi
The aim of this work was to examine foaming and interfacial behavior of three milk protein mixtures, bovine α-lactalbumin-β-casein (M1), camel α-lactalbumin-β-casein (M2) and β-lactoglobulin-β-casein (M3), alone and in binary mixtures, at the air/water interface in order to better understand the foaming properties of bovine and camel milks. Different mixture ratios (100:0; 75:25; 50:50; 25:75; 0:100) were used during foaming tests and interfacial protein interactions were studied with a pendant drop tensiometer...
December 10, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28030637/quality-matters-influences-of-citrus-flush-physicochemical-characteristics-on-population-dynamics-of-the-asian-citrus-psyllid-hemiptera-liviidae
#12
Mamoudou Sétamou, Catherine R Simpson, Olufemi J Alabi, Shad D Nelson, Srilakshmi Telagamsetty, John L Jifon
Studies were conducted to relate the influence of the physical characteristics, leaf nutrient content and phloem sap amino acid concentration of citrus flush shoots on the densities of various Diaphorina citri life stages. Adult D. citri preferentially selected young shoots for feeding and numbers of D. citri immatures were positively correlated with flush shoot softness. Young flush shoots had higher concentrations of macro and micro nutrients relative to mature ones and this was associated with higher densities of all D...
2016: PloS One
https://www.readbyqxmd.com/read/28010785/long-term-outcomes-of-kidney-transplantation-in-people-with-type-2-diabetes-a-population-cohort-study
#13
Wai H Lim, Germaine Wong, Helen L Pilmore, Stephen P McDonald, Steven J Chadban
BACKGROUND: Overall survival for younger patients with type 2 diabetes without kidney disease has improved substantially over time, but whether a similar pattern of improvement is observed in diabetic kidney transplant recipients remained uncertain. We aimed to compare patient outcomes between diabetic and non-diabetic transplant recipients, and to determine the effect of age and era on patient survival. METHODS: This population cohort study included all primary kidney-only transplant recipients included in the Australia and New Zealand Dialysis and Transplant registry between Jan 1, 1994, and Dec 31, 2012...
January 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28010774/recombinant-cellulolytic-or-xylanolytic-complex-comprising-the-full-length-scaffolding-protein-rjcipa-and-cellulase-rjcel5b-or-xylanase-rjxyn10c-of-ruminiclostridium-josui
#14
Taku Orita, Makiko Sakka, Tetsuya Kimura, Kazuo Sakka
Three cellulosomal subunits of Ruminiclostridium josui, the full-length scaffolding protein CipA (RjCipA), a cellulase Cel5B (RjCel5B) and a xylanase Xyn10C (RjXyn10C), were successfully produced by Escherichia coli recombinant clones. RjCel5B and RjXyn10C were characterized as an endoglucanase and an endoxylanase, respectively. RjCipA, RjCel5B and Xyn10C adsorbed to microcrystalline cellulose (Funacel) and rice straw powder. Interaction between RjCel5B and RjCipA, and RjXyn10C and RjCipA were confirmed by qualitative assays...
February 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/28007199/coronary-artery-bypass-surgery-versus%C3%A2-drug-eluting-stent-implantation-for%C3%A2-left%C3%A2-main-or-multivessel-coronary-artery%C3%A2-disease-a-meta-analysis-of-individual-patient-data
#15
Cheol Whan Lee, Jung-Min Ahn, Rafael Cavalcante, Yohei Sotomi, Yoshinobu Onuma, Pannipa Suwannasom, Erhan Tenekecioglu, Sung-Cheol Yun, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Seong-Wook Park, Patrick W Serruys, Seung-Jung Park
OBJECTIVES: The authors undertook a patient-level meta-analysis to compare long-term outcomes after coronary artery bypass grafting (CABG) versus percutaneous coronary intervention (PCI) with drug-eluting stents (DES) in 3,280 patients with left main or multivessel coronary artery disease (CAD). BACKGROUND: The relative efficacy and safety of CABG versus PCI with DES for left main or multivessel CAD remain controversial. METHODS: Data were pooled from the BEST (Randomized Comparison of Coronary Artery Bypass Surgery and Everolimus Eluting Stent Implantation in the Treatment of Patients With Multivessel Coronary Artery Disease), PRECOMBAT (Premier of Randomized Comparison of Bypass Surgery vs...
December 26, 2016: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28005702/time-to-the-peak-of-the-aortic-forward-wave-determines-the-impact-of-aortic-backward-wave-and-pulse-pressure-on-left-ventricular-mass
#16
Grace Tade, Gavin R Norton, Hendrik L Booysen, Moekanyi J Sibiya, Imraan Ballim, Pinhas Sareli, Elena Libhaber, Olebogeng H I Majane, Angela J Woodiwiss
AIM: To determine the degree to which an extended time to the peak of the aortic forward wave or early wave reflection time enhance associations between aortic backward wave pressure and hence central aortic pulse pressure (PPc) and left ventricular mass index (LVMI). METHODS: In 701 adult participants from a community sample either receiving no antihypertensive therapy or receiving low-dose thiazide diuretic monotherapy for at least a year (the major therapy employed), we assessed aortic haemodynamics (SphygmoCor software and wave separation analysis; AtCor Medical, West Ryder, New South Wales, Australia) and LVMI (echocardiography)...
February 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/27992390/the-effect-of-cochlear-damage-on-the-sensitivity-to-harmonicity
#17
Damien Bonnard, René Dauman, Catherine Semal, Laurent Demany
OBJECTIVES: A sum of simultaneous pure tones with harmonic relationships (i.e., simple frequency ratios) is normally heard as a single sound, with a single pitch, even when its components are fully resolved in the auditory periphery. This perceptual phenomenon called "harmonic fusion" is thought to play an important role in auditory scene analysis as listeners often have to segregate simultaneous harmonic sounds with different fundamental frequencies. The present study explored the consequences of mild or moderate cochlear hearing loss for the sensitivity to harmonicity and the detection of inharmonicity...
January 2017: Ear and Hearing
https://www.readbyqxmd.com/read/27991750/fabrication-of-patterned-thermoresponsive-microgel-strips-on-cell-adherent-background-and-their-application-for-cell-sheet-recovery
#18
Yongqing Xia, Ying Tang, Han Wu, Jing Zhang, Zongyi Li, Fang Pan, Shengjie Wang, Xiaojuan Wang, Hai Xu, Jian Ren Lu
Interfaces between materials and cells play a critical role in cell biomedical applications. Here, a simple, robust, and cost-effective method is developed to fabricate patterned thermoresponsive poly(N-isopropylacrylamide-co-styrene) microgel strips on a polyethyleneimine-precoated, non-thermoresponsive cell-adherent glass coverslip. The aim is to investigate whether cell sheets could be harvested from these cell-adherent surfaces patterned with thermoresponsive strips comprised of the microgels. We hypothesize that if the cell-to-cell interaction is strong enough to retain the whole cell sheet from disintegration, the cell segments growing on the thermoresponsive strips may drag the cell segments growing on the cell-adherent gaps to detach, ending with a whole freestanding and transferable cell sheet...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27990748/how-the-use-of-nitrogen-fertiliser-may-switch-plant-suitability-for-aphids-the-case-of-miscanthus-a-promising-biomass-crop-and-the-aphid-pest-rhopalosiphum-maidis
#19
F Bogaert, Q Chesnais, M Catterou, C Rambaud, G Doury, A Ameline
BACKGROUND: The use of nitrogen fertiliser in agrosystems can alter plant nitrogen and consequently improve nutrient availability for herbivores, potentially leading to better performance for herbivores and higher pest pressure in the field. RESULTS: We compared, in laboratory conditions, the effects of nitrogen fertilisation on a promising biomass crop, Miscanthus x giganteus, and its parents Miscanthus sinensis and Miscanthus sacchariflorus. The plant-mediated effects were compared on the second trophic level, the green corn leaf aphid Rhopalosiphum maidis...
December 19, 2016: Pest Management Science
https://www.readbyqxmd.com/read/27966970/anionic-and-cationic-silver-nanoparticle-binding-restructures-net-anionic-pc-pg-monolayers-with-saturated-or-unsaturated-lipids
#20
G D Bothun, N Ganji, I A Khan, A Xi, C Bobba
We have examined the interactions between polymer-coated anionic (Ag-COOH) and cationic (Ag-NH) silver nanoparticles, and net-anionic lipid monolayers using dynamic surface pressure measurements. Monolayers composed of saturated or monounsaturated mixtures of anionic phosphatidylglycerol (PG) and zwitterionic phosphatidylcholine (PC) lipids (3:1 molar ratio) were used to determine how lipid packing and monolayer phase state influence the extent of nanoparticle binding and the monolayer response. Anionic Ag-COOH inserted into saturated dipalmitoyl-PC/PG (DPPC/DPPG) and dioleoyl-PC/PG (DOPC/DOPG) monolayers at a low initial surface pressure (10 mN m(-1)) and caused lipid condensation at high initial surface pressures (20 and 30 mN m(-1))...
December 30, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
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