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https://www.readbyqxmd.com/read/29340584/long-interval-intracortical-inhibition-as-biomarker-for-epilepsy-a-transcranial-magnetic-stimulation-study
#1
Prisca R Bauer, Annika A de Goede, William M Stern, Adam D Pawley, Fahmida A Chowdhury, Robert M Helling, Romain Bouet, Stiliyan N Kalitzin, Gerhard H Visser, Sanjay M Sisodiya, John C Rothwell, Mark P Richardson, Michel J A M van Putten, Josemir W Sander
Cortical excitability, as measured by transcranial magnetic stimulation combined with electromyography, is a potential biomarker for the diagnosis and follow-up of epilepsy. We report on long-interval intracortical inhibition data measured in four different centres in healthy controls (n = 95), subjects with refractory genetic generalized epilepsy (n = 40) and with refractory focal epilepsy (n = 69). Long-interval intracortical inhibition was measured by applying two supra-threshold stimuli with an interstimulus interval of 50, 100, 150, 200 and 250 ms and calculating the ratio between the response to the second (test stimulus) and to the first (conditioning stimulus)...
January 11, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29330535/the-stoichiometry-of-coral-dinoflagellate-symbiosis-carbon-and-nitrogen-cycles-are-balanced-in-the-recycling-and-double-translocation-system
#2
Yasuaki Tanaka, Atsushi Suzuki, Kazuhiko Sakai
Symbioses between microalgae and animal hosts have the advantage of acquiring and sharing autotrophically produced organic carbon (C) as their energy source. However, the stoichiometry and turnover rates of biological elements in symbioses are not fully understood because of complicated metabolic interactions. We report the first comprehensive and simultaneous measurement of C and nitrogen (N) flows through coral-dinoflagellate symbiosis by using the unique approach of dual-isotope labeling with 13C and 15N, in situ chasing, and isotope-mixing models...
January 12, 2018: ISME Journal
https://www.readbyqxmd.com/read/29325802/utilization-of-large-volume-zwitterionic-hydrophilic-interaction-liquid-chromatography-for-the-analysis-of-polar-pharmaceuticals-in-aqueous-environmental-samples-benefits-and-limitations
#3
Lise Boulard, Georg Dierkes, Thomas Ternes
Benefits and limitations of HILIC were studied for the analysis of extreme polar organic contaminants in aqueous environmental matrices. A sensitive analytical method was developed and validated for the detection of 11 pharmaceuticals, 15 pharmaceutical metabolites and transformation products and the artificial sweetener acesulfame in aqueous environmental samples. The analytical method consisted of a simple and non-specific sample preparation based on freeze-drying followed by detection with large injection volume (70 μL) zwitterionic HILIC-ESI-MS/MS...
December 11, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29324576/intermittent-cooling-during-judo-training-in-a-warm-humid-environment-reduces-autonomic-and-hormonal-impact
#4
Eduardo Carballeira, José Morales, David H Fukuda, María L Granada, Vicente Carratalá-Deval, Alfonso López Díaz de Durana, Jeffrey R Stout
The purpose of this study was to identify the effects of superficial cooling on physiological responses while training in a warm, humid environment during an international judo training camp. Sixteen judokas (8 women and 8 men) participated in the experiment. Four high-level women and four men were randomly assigned to wear a cooling vest (vest group, VG) during the recovery periods within a training session (i.e. 8 bouts of 5 min fighting with 5 min rest) and up to 10 min after the session, while the remaining athletes in the control group (CG) trained without the use of any cooling aids...
January 5, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29324263/the-role-of-pro-fibrotic-biomarkers-in-paroxysmal-and-persistent-atrial-fibrillation
#5
Adina Elena Stanciu, Radu Gabriel Vatasescu, Marcel Marian Stanciu, Nafija Serdarevic, Maria Dorobantu
PURPOSE: Signaling pathways involved in electrical, structural and contractile remodeling processes behind development and progression of atrial fibrillation (AF) have not been completely elucidated, but it seems to be related to complex interactions among neurohormonal and cellular mediators. We aimed to investigate interleukin-6 (IL-6), transforming growth factor-beta1 (TGF-β1), matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), as biomarkers of atrial remodeling, in patients with paroxysmal and persistent AF, and their correlation with N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and left atrial (LA) diameter...
January 8, 2018: Cytokine
https://www.readbyqxmd.com/read/29321897/nutrient-stoichiometry-and-land-use-rather-than-species-richness-determine-plant-functional-diversity
#6
Verena Busch, Valentin H Klaus, Caterina Penone, Deborah Schäfer, Steffen Boch, Daniel Prati, Jörg Müller, Stephanie A Socher, Ülo Niinemets, Josep Peñuelas, Norbert Hölzel, Markus Fischer, Till Kleinebecker
Plant functional traits reflect individual and community ecological strategies. They allow the detection of directional changes in community dynamics and ecosystemic processes, being an additional tool to assess biodiversity than species richness. Analysis of functional patterns in plant communities provides mechanistic insight into biodiversity alterations due to anthropogenic activity. Although studies have consi-dered of either anthropogenic management or nutrient availability on functional traits in temperate grasslands, studies combining effects of both drivers are scarce...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29318328/contrasting-network-features-between-free-living-and-particle-attached-bacterial-communities-in-taihu-lake
#7
Huimin Xu, Dayong Zhao, Rui Huang, Xinyi Cao, Jin Zeng, Zhongbo Yu, Katherine V Hooker, K David Hambright, Qinglong L Wu
Free-living (FL) and particle-attached (PA) bacterial communities play critical roles in nutrient cycles, metabolite production, and as a food source in aquatic systems, and while their community composition, diversity, and functions have been well studied, we know little about their community interactions, co-occurrence patterns, and niche occupancy. In the present study, 13 sites in Taihu Lake were selected to study the differences of co-occurrence patterns and niches occupied between the FL and PA bacterial communities using correlation-based network analysis...
January 9, 2018: Microbial Ecology
https://www.readbyqxmd.com/read/29317335/integrated-case-control-and-somatic-germline-interaction-analyses-of-melanoma-susceptibility-genes
#8
Yao Yu, Hao Hu, Jiun-Sheng Chen, Fulan Hu, Jerry Fowler, Paul Scheet, Hua Zhao, Chad D Huff
While a number of genes have been implicated in melanoma susceptibility, the role of protein-coding variation in melanoma development and progression remains underexplored. To better characterize the role of germline coding variation in melanoma, we conducted a whole-exome case-control and somatic-germline interaction study involving 322 skin cutaneous melanoma cases from The Cancer Genome Atlas and 3607 controls of European ancestry. We controlled for cross-platform technological stratification using XPAT and conducted gene-based association tests using VAAST 2...
January 6, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29309983/interaction-between-the-contributions-of-tumor-location-tumor-grade-and-patient-age-to-the-survival-benefit-associated-with-gross-total-resection-gtr
#9
Kate T Carroll, Alex K Bryant, Brian Hirshman, Ali A Alattar, Rushikesh Joshi, Brandon Gabel, Bob S Carter, Olivier Harismendy, Florin Vaida, Clark C Chen
BACKGROUND: Gross total resection (GTR) in glioblastoma (GB) and anaplastic astrocytoma (AA) patients is associated with improved survival. Here, we examine how this benefit is affected by tumor location, tumor grade, and age. METHODS: We selected patients in SEER with lobar AA or GB from 1999 to 2010. Survival analyses were performed using Kaplan-Meier curves and Cox proportional hazards models. RESULTS: We identified and studied 1,429 AA patients and 12,537 GB patients in the SEER database with lobar tumors...
January 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29301646/impact-of-sex-on-comparative-outcomes-of-radial-versus-femoral-access-in-patients-with-acute-coronary-syndromes-undergoing-invasive-management-data-from-the-randomized-matrix-access-trial
#10
Giuseppe Gargiulo, Sara Ariotti, Pascal Vranckx, Sergio Leonardi, Enrico Frigoli, Nestor Ciociano, Carlo Tumscitz, Francesco Tomassini, Paolo Calabrò, Stefano Garducci, Gabriele Crimi, Giuseppe Andò, Maurizio Ferrario, Ugo Limbruno, Bernardo Cortese, Paolo Sganzerla, Alessandro Lupi, Filippo Russo, Roberto Garbo, Arturo Ausiello, Dennis Zavalloni, Gennaro Sardella, Giovanni Esposito, Andrea Santarelli, Simone Tresoldi, Marco Stefano Nazzaro, Antonio Zingarelli, Anna Sonia Petronio, Stephan Windecker, Bruno R da Costa, Marco Valgimigli
OBJECTIVES: This study sought to assess whether transradial access (TRA) compared with transfemoral access (TFA) is associated with consistent outcomes in male and female patients with acute coronary syndrome undergoing invasive management. BACKGROUND: There are limited and contrasting data about sex disparities for the safety and efficacy of TRA versus TFA for coronary intervention. METHODS: In the MATRIX (Minimizing Adverse Haemorrhagic Events by TRansradial Access Site and Systemic Implementation of angioX) program, 8,404 patients were randomized to TRA or TFA...
January 8, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29300080/mineralogical-controls-on-the-bioaccessibility-of-arsenic-in-fe-iii-as-v-coprecipitates
#11
Katrin Ehlert, Christian Mikutta, Yuan Jin, Ruben Kretzschmar
X-ray amorphous Fe(III)-As(V) coprecipitates are common initial products of oxidative As- and Fe-bearing sulfide weathering, and often control As solubility in mine wastes or mining-impacted soils. The formation conditions of these solids may exert a major control on their mineralogical composition and, hence, As release in the gastric tract of humans after incidental ingestion of As-contaminated soil. Here, we synthesized a set of 35 Fe(III)-As(V) coprecipitates as a function of pH (1.5-8) and initial molar Fe/As ratio (0...
January 4, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29290732/on-modelling-the-interaction-between-two-rotating-bodies-with-statistically-distributed-features-an-application-to-dressing-of-grinding-wheels
#12
A Spampinato, D A Axinte
The mechanisms of interaction between bodies with statistically arranged features present characteristics common to different abrasive processes, such as dressing of abrasive tools. In contrast with the current empirical approach used to estimate the results of operations based on attritive interactions, the method we present in this paper allows us to predict the output forces and the topography of a simulated grinding wheel for a set of specific operational parameters (speed ratio and radial feed-rate), providing a thorough understanding of the complex mechanisms regulating these processes...
December 2017: Proceedings. Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29289667/intrinsic-viscosity-of-binary-gum-mixtures-with-xanthan-gum-and-guar-gum-effect-of-nacl-sucrose-and-ph
#13
J H Bak, B Yoo
The intrinsic viscosity [η] values of binary gum mixtures with xanthan gum (XG) and guar gum (GG) mixed with NaCl and sucrose at different concentrations as well as in the presence of different pH levels were examined in dilute solution as a function of XG/GG mixing ratio (100/0, 75/25, 50/50, and 0/100). Experimental values of concentration (C) and relative viscosity (ηrel) or specific viscosity (ηsp) of gums in dilute solution were fitted to five models to determine intrinsic viscosity [η] values of binary gum mixtures including individual gums...
December 28, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29286102/pin1-facilitates-isoproterenol%C3%A2-induced-cardiac-fibrosis-and-collagen-deposition-by-promoting-oxidative-stress-and-activating-the-mek1-2%C3%A2-erk1-2-signal-transduction-pathway-in-rats
#14
Xian Wu, Mingjiang Li, Su-Qin Chen, Sha Li, Furong Guo
Peptidyl‑prolyl cis/trans isomerase, NIMA-interacting 1 (Pin1) is a member of a large superfamily of phosphorylation‑dependent peptidyl‑prolyl cis/trans isomerases, which not only regulates multiple targets at various stages of cellular processes, but is also involved in the pathogenesis of several diseases, including microbial infection, cancer, asthma and Alzheimer's disease. However, the role of Pin1 in cardiac fibrosis remains to be fully elucidated. The present study investigated the potential mechanism of Pin1 in isoprenaline (ISO)‑induced myocardial fibrosis in rats...
December 29, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29281964/the-molecular-evolutionary-dynamics-of-oxidative-phosphorylation-oxphos-genes-in-hymenoptera
#15
Yiyuan Li, Rui Zhang, Shanlin Liu, Alexander Donath, Ralph S Peters, Jessica Ware, Bernhard Misof, Oliver Niehuis, Michael E Pfrender, Xin Zhou
BACKGROUND: The primary energy-producing pathway in eukaryotic cells, the oxidative phosphorylation (OXPHOS) system, comprises proteins encoded by both mitochondrial and nuclear genes. To maintain the function of the OXPHOS system, the pattern of substitutions in mitochondrial and nuclear genes may not be completely independent. It has been suggested that slightly deleterious substitutions in mitochondrial genes are compensated by substitutions in the interacting nuclear genes due to positive selection...
December 28, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29279046/human-wharton-s-jelly-cells-activate-degenerative-nucleus-pulposus-cells-in-vitro
#16
Zhihua Han, Yan Zhang, Liang Gao, Shujun Jiang, Di-Ke Ruan
In order to investigate the interaction between human Wharton's jelly cells (WJCs) and degenerative nucleus pulposus cells (NPCs), human WJCs were cocultured with degenerative NPCs with or without direct cell-cell contact. WJCs were isolated from the human umbilical cord and degenerative NPCs were isolated from the surgically obtained degenerative intervertebral disc tissue. The isolated WJCs positively expressed CD73, CD105, CD90, CD29, CD166 and human leukocyte antigen (HLA)-ABC, but negatively expressed CD34, CD45, and HLA-DR...
December 27, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29277987/bioinspired-manganese-chelated-alginate-poly-dopamine-nanomaterials-for-efficient-in-vivo-t1%C3%A2-weighted-magnetic-resonance-imaging-mri
#17
Kefyalew Dagnew Addisu, Balkew Zewge Hailemeskel, Shewaye Lakew Mekuria, Abegaz Tizazu Andrgie, Yu-Chun Lin, Hsieh-Chih Tsai
Manganese-based nanomaterials are an emerging new class of magnetic resonance imaging (MRI) contrast agents (CAs) that provide impressive contrast abilities. MRI CAs that can respond to pathophysiological parameters like pH or redox potential are also highly demanded for MRI guided tumor diagnosis. Until now, synthesizing nanomaterials with good biocompatibility, physio-chemical stability, and good contrast effects remain challenging. This study investigated two new systems of calcium/manganese cations complexed with either alginate-polydopamine or alginate-dopamine nanogels (AlgPDA(Ca/Mn) NG or AlgDA (Ca/Mn) NG)...
December 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29261287/plexcitons-the-role-of-oscillator-strengths-and-spectral-widths-in-determining-strong-coupling
#18
Reshmi Thomas, Anoop Thomas, Saranya Pullanchery, Linta Joseph, Sanoop Mambully Somasundaran, Rotti Srinivasamurthy Swathi, Stephen K Gray, K George Thomas
Strong coupling interactions between plasmon and exciton-based excitations have been proposed to be useful in the design of optoelectronic systems. However, the role of various optical parameters dictating the plasmon-exciton (plexciton) interactions is less understood. Herein, we propose an inequality for achieving strong coupling between plasmons and excitons through appropriate variation of their oscillator strengths and spectral widths. These aspects are found to be consistent with experiments on two sets of free-standing plexcitonic systems obtained by (i) linking fluorescein isothiocyanate on Ag nanoparticles of varying sizes through silane coupling and (ii) electrostatic binding of cyanine dyes on polystyrenesulfonate-coated Au nanorods of varying aspect ratios...
December 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/29247072/vascular-and-dopaminergic-contributors-to-mild-parkinsonian-signs-in-older-adults
#19
Andrea L Rosso, Nicolaas I Bohnen, Lenore J Launer, Howard J Aizenstein, Kristine Yaffe, Caterina Rosano
OBJECTIVE: Mild parkinsonian signs (MPS) are an underappreciated neurologic condition in older adults; we assessed associations of MPS with measures of dopaminergic (catechol-O-methyltransferase [COMT] genotype, an indicator of synaptic dopamine levels) and vascular (white matter hyperintensities [WMH], an indicator of cerebral small vessel disease) factors. METHODS: In a cohort of older adults (mean age 82.6 years [SD 2.6]; 58.0% female; 38.8% black), we assessed cross-sectional associations of WMH volume and COMT Val158Met (rs4680) genotype (n = 35 Met/Met, n = 180 Val carriers) with MPS by regression models adjusted for demographic and health characteristics...
December 15, 2017: Neurology
https://www.readbyqxmd.com/read/29242340/anomalous-spin-correlations-and-excitonic-instability-of-interacting-2d-weyl-fermions
#20
Michihiro Hirata, Kyohei Ishikawa, Genki Matsuno, Akito Kobayashi, Kazuya Miyagawa, Masafumi Tamura, Claude Berthier, Kazushi Kanoda
The Coulomb interaction in systems of quasi-relativistic massless electrons has an unscreened long-range component at variance with conventional correlated metals. We used nuclear magnetic resonance (NMR) measurements to reveal unusual spin correlations of two-dimensional Weyl fermions in an organic material, causing a divergent increase of the Korringa ratio by a factor of 1000 upon cooling, in marked contrast to conventional metallic behavior. Combined with model calculations, we show that this divergence stems from an interaction-driven velocity renormalization that almost exclusively suppresses zero-momentum spin fluctuations...
December 15, 2017: Science
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