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Relative excess risk due to interaction

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https://www.readbyqxmd.com/read/28737433/association-and-interaction-between-triglyceride-glucose-index-and-obesity-on-risk-of-hypertension-in-middle-aged-and-elderly-adults
#1
Song Jian, Nie Su-Mei, Chen Xue, Zhang Jie, Wu Xue-Sen
AIMS: To investigate the association between triglyceride-glucose(TyG) index and the risk of hypertension. METHOD: A cross-sectional study was conducted in Bengbu, China. The participants received relevant questionnaire survey, anthropometric tests, and laboratory examination. Multivariate logistic regression analysis was performed to estimate the possible association between TyG index and hypertension risk. The additive interaction evaluated by the relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), and synergy index(SI) was calculated...
July 24, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28701338/lifestyle-in-progression-from-hypertensive-disorders-of-pregnancy-to-chronic-hypertension-in-nurses-health-study-ii-observational-cohort-study
#2
Simon Timpka, Jennifer J Stuart, Lauren J Tanz, Eric B Rimm, Paul W Franks, Janet W Rich-Edwards
Objectives To study the association between lifestyle risk factors and chronic hypertension by history of hypertensive disorders of pregnancy (HDP: gestational hypertension and pre-eclampsia) and investigate the extent to which these risk factors modify the association between HDP and chronic hypertension.Design Prospective cohort study.Setting Nurses' Health Study II (1991-2013).Participants 54 588 parous women aged 32 to 59 years with data on reproductive history and without previous chronic hypertension, stroke, or myocardial infarction...
July 12, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28666636/high-hepatitis-c-incidence-in-relation-to-prescription-opioid-injection-and-poly-drug-use-assessing-barriers-to-hepatitis-c-prevention
#3
Svetlana Puzhko, Élise Roy, Didier Jutras-Aswad, Andreea Adelina Artenie, Emmanuel Fortier, Geng Zang, Julie Bruneau
BACKGROUND: Prescription opioid (PO) injection and poly-drug use have been associated with hepatitis C virus (HCV) infection among people who inject drugs (PWID). Poly-drug use is often a barrier to key HCV preventive programmes including opioid agonist treatment. The contribution of specific drug combinations to high HCV incidence in poly-drug users has not been assessed previously. Addressing this knowledge gap could enhance HCV treatment and prevention efforts. We examined the association between specific drugs and number of drugs used in addition to injected POs, and HCV seroconversion...
June 27, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28664715/the-history-of-arsenical-pesticides-and-health-risks-related-to-the-use-of-agent-blue
#4
Vladimir Bencko, Florence Yan Li Foong
Arsenicals in agriculture. Beginning in the 1970s, the use of arsenic compounds for such purposes as wood preservatives, began to grow. By 1980, in the USA, 70% of arsenic had been consumed for the production of wood preservatives. This practice was later stopped, due to the US Environmental Protection Agency (EPA) ban of the arsenic-and chromium-based wood preservative chromated copper arsenate. In the past, arsenical herbicides containing cacodylic acid as an active ingredient have been used extensively in the USA, from golf courses to cotton fields, and drying-out the plants before harvesting...
June 12, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28653077/work-related-biomechanical-exposure-and-job-strain-in-midlife-separately-and-jointly-predict-disability-after-28-years-a-finnish-longitudinal-study
#5
K C Prakash, Subas Neupane, Päivi Leino-Arjas, Mikaela B von Bonsdorff, Taina Rantanen, Monika E von Bonsdorff, Jorma Seitsamo, Juhani Ilmarinen, Clas-Håkan Nygård
Objectives We investigated whether the extent of biomechanical exposures and job strain in midlife separately and jointly predict disability in old age. Methods Participants of the Finnish Longitudinal Study on Aging Municipal Employees (FLAME) in 1981 (aged 44-58 years) responded to disability questionnaires in 2009 (1850 women and 1082 men). Difficulties in performing five activities of daily living (ADL) and seven instrumental ADL (IADL) were used to assess severity of disability (score range: 0-12, 0=no disability)...
June 26, 2017: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/28651396/-interaction-between-family-history-of-diabetes-and-hyperlipidemia-on-risk-of-diabetes-in-population-with-normotension-in-harbin-a-cross-sectional-study
#6
C D Bao, B Sun, L Lan, H Qiao, D F Zhang, X Y Liu, J Wang, Y S Zhao
Objective: To explore the interaction between family history of diabetes and hyperlipidemia on the risk of diabetes in population with normotension. Methods: A multistage stratified probability random sampling was conducted to select a representative sample of urban residents aged 20-74 years in Harbin. A total of 376 diabetes patients with normotension and 3 692 residents with normal blood pressure, normal fasting glucose, and normal 2 hours glucose from OGTT were surveyed. The interaction was evaluated by using crossover analysis and additive model...
May 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28641376/height-weight-and-aerobic-fitnessin-relation-to-risk-of-atrial-fibrillation
#7
Casey Crump, Jan Sundquist, Marilyn A Winkleby, Kristina Sundquist
Tall stature or obesity has been associated with higher risk of atrial fibrillation (AF), but reported effects of aerobic fitness have been conflicting. A national cohort study was conducted to examine interactions between height or weight and aerobic fitness among 1,547,478 Swedish military conscripts during 1969-1997 (97-98% of all 18-year-old males) in relation to AF identified from nationwide inpatient and outpatient diagnoses through 2012 (maximum age 62). Increased height, weight, or aerobic fitness (but not muscular strength) at age 18 was associated with higher AF risk in adulthood...
June 21, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28633381/robust-tests-for-additive-gene-environment-interaction-in-case-control-studies-using-gene-environment-independence
#8
Gang Liu, Seunggeun Lee, Alice W Lee, Anna H Wu, Elisa V Bandera, Allan Jensen, Mary Anne Rossing, Kirsten B Moysich, Jenny Chang-Claude, Jennifer Doherty, Aleksandra Gentry-Maharaj, Lambertus Kiemeney, Simon A Gayther, Francesmary Modugno, Leon Massuger, Ellen L Goode, Brooke Fridley, Kathryn L Terry, Daniel W Cramer, Susan J Ramus, Hoda Anton-Culver, Argyrios Ziogas, Jonathan P Tyrer, Joellen M Schildkraut, Susanne K Kjaer, Penelope M Webb, Roberta B Ness, Usha Menon, Andrew Berchuck, Paul D Pharoah, Harvey Risch, Celeste Leigh Pearce, Bhramar Mukherjee
There have been recent proposals advocating the use of additive gene-environment interaction instead of the widely used multiplicative scale, as a more relevant public health measure. Using gene-environment independence enhances the power for testing multiplicative interaction in case-control studies. However, under departure from this assumption, substantial bias in the estimates and inflated Type I error in the corresponding tests can occur. This paper extends the empirical Bayes (EB) approach previously developed for multiplicative interaction that trades off between bias and efficiency in a data-adaptive way, to the additive scale...
June 14, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28615149/cardiovascular-and-metabolic-effects-of-metformin-in-patients-with-type-1-diabetes-removal-a-double-blind-randomised-placebo-controlled-trial
#9
John R Petrie, Nishi Chaturvedi, Ian Ford, Martijn C G J Brouwers, Nicola Greenlaw, Therese Tillin, Irene Hramiak, Alun D Hughes, Alicia J Jenkins, Barbara E K Klein, Ronald Klein, Teik C Ooi, Peter Rossing, Coen D A Stehouwer, Naveed Sattar, Helen M Colhoun
BACKGROUND: Metformin might reduce insulin requirement and improve glycaemia in patients with type 1 diabetes, but whether it has cardiovascular benefits is unknown. We aimed to investigate whether metformin treatment (added to titrated insulin therapy) reduced atherosclerosis, as measured by progression of common carotid artery intima-media thickness (cIMT), in adults with type 1 diabetes at increased risk for cardiovascular disease. METHODS: REMOVAL was a double-blind, placebo-controlled trial undertaken at 23 hospital diabetes clinics in five countries (Australia, Canada, Denmark, the Netherlands, and the UK)...
June 9, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28584635/interactions-between-polymorphisms-in-the-3-untranslated-region-of-the-cyclin-dependent-kinase-6-gene-and-the-human-papillomavirus-infection-and-risk-of-cervical-precancerous-lesions
#10
Xingguang Ye, Lipeng Jing, Xingming Zhong, Di Xiao, Meiling Ou, Congcong Guo, Guang Yang, Chunxia Jing, Xiangcai Wei
The human papillomavirus (HPV) infection is essential for the development of cervical cancer and its precursor lesions. However, only certain persistently infected individuals develop cervical cancer. Cyclin-dependent kinase 6 (CDK6) is a critical regulatory cancer-associated gene in the cell cycle and in tumorigenesis. Single nucleotide polymorphisms (SNPs) in microRNA sites in the 3'-untranslated region (UTR) of target genes may result in target gene expression level changes and susceptibility to diseases, including cancer...
June 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28580624/coupled-effects-of-wind-storms-and-drought-on-tree-mortality-across-115-forest-stands-from-the-western-alps-and-the-jura-mountains
#11
Katalin Csilléry, Georges Kunstler, Benoît Courbaud, Denis Allard, Pierre Lassegues, Klaus Haslinger, Barry Gardiner
Damage due to wind storms and droughts are increasing in many temperate forest, yet little is known about the long-term roles of these key climatic factors in forest dynamics and in the carbon budget. The objective of this study was to estimate individual and coupled effects of droughts and wind-storms on adult tree mortality across a 31-year period in 115 managed, mixed-coniferous forest stands from the Western Alps and the Jura mountains. For each stand, yearly mortality was inferred from management records, yearly drought from interpolated fields of monthly temperature, precipitation and soil water holding capacity, and wind-storms from interpolated fields of daily maximum wind-speed...
June 5, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28576267/age%C3%A2-%C3%A3-gender-interaction-effect-on-resuscitation-outcomes-in-patients-with-out-of-hospital-cardiac-arrest
#12
Akihito Hagihara, Daisuke Onozuka, Junko Ono, Takashi Nagata, Manabu Hasegawa
Although an interaction between gender and age has been shown to influence resuscitation outcomes in patients with out-of-hospital cardiac arrest (OHCA), this interaction has not been investigated in Asian populations. In this prospective, observational study, data from all cases of OHCA in Japan between 2005 and 2012 were obtained from the Japanese National Registry. We determined the relative excess risk due to interaction and the ratio of odds ratios (ORs) to assess the interaction effect of gender and age on the incidence of return of spontaneous circulation (ROSC) before hospital arrival, 1-month survival, and neurologically intact survival 1 month after OHCA...
August 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28566527/interactions-between-5-lipoxygenase-polymorphisms-and-adipose-tissue-contents-of-arachidonic-and-eicosapentaenoic-acids-do-not-affect-risk-of-myocardial-infarction-in-middle-aged-men-and-women-in-a-danish-case-cohort-study
#13
Anders Gammelmark, Søren Lundbye-Christensen, Anne Tjønneland, Erik B Schmidt, Kim Overvad, Michael S Nielsen
Background: The 5-lipoxygenase pathway has been linked to atherothrombotic disease, and a functional tandem repeat polymorphism in the arachidonate lipoxygenase-5 (ALOX-5) gene has been associated with the risk of myocardial infarction (MI). Interestingly, 2 studies have reported an interaction between dietary intakes of the ALOX-5 substrates, arachidonic acid (AA) and eicosapentaenoic acid (EPA), and genotype.Objective: We investigated whether the interactions between the ALOX-5 tandem repeat polymorphism (rs59439148) and adipose tissue AA and EPA were associated with incident MI...
July 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28553992/does-age-modify-the-association-between-psychosocial-factors-at-work-and-deterioration-of-self-rated-health
#14
Hermann Burr, Hans Martin Hasselhorn, Norbert Kersten, Anne Pohrt, Reiner Rugulies
Objectives Few epidemiological studies have examined whether associations of psychosocial working conditions with risk of poor health differ by age. Based on results from mostly cross-sectional studies, we test whether (i) psychosocial relational factors (social support) are more strongly associated with declining health of older than younger employees and (ii) psychosocial job factors (workpace, influence, possibilities for development) are more strongly associated with declining health of younger than older employees...
May 29, 2017: Scandinavian Journal of Work, Environment & Health
https://www.readbyqxmd.com/read/28529598/biological-interaction-of-cigarette-smoking-on-the-association-between-genetic-polymorphisms-involved-in-inflammation-and-the-risk-of-lung-cancer-a-case-control-study-in-japan
#15
Yuzo Yamamoto, Chikako Kiyohara, Saiko Suetsugu-Ogata, Naoki Hamada, Yoichi Nakanishi
Chronic inflammation serves an important role in lung carcinogenesis, thus genetic polymorphisms involved in this pathway may affect the risk of lung cancer. The present case-control study focused on the association between lung cancer risk and genetic polymorphisms involved in inflammatory pathways. The study comprised 462 lung cancer cases and 379 controls from Japan. The roles of interleukin 8 (IL8) rs4073, nuclear factor kappa B (NFκB) rs28362491, cytochrome b-245, alpha polypeptide (CYBA) rs4673, NAD(P) H dehydrogenase, quinone 1 (NQO1) rs1800566, nitric oxide synthase 2 and inducible (NOS2) rs2297518 polymorphisms in lung carcinogenesis were investigated...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28520847/maternal-exposure-to-nitrogen-dioxide-intake-of-methyl-nutrients-and-congenital-heart-defects-in-offspring
#16
Jeanette A Stingone, Thomas J Luben, Suzan L Carmichael, Arthur S Aylsworth, Lorenzo D Botto, Adolfo Correa, Suzanne M Gilboa, Peter H Langlois, Wendy N Nembhard, Jennifer Richmond-Bryant, Gary M Shaw, Andrew F Olshan
Nutrients that regulate methylation processes may modify susceptibility to the effects of air pollutants. Data from the National Birth Defects Prevention Study, 1997-2006, were used to estimate associations between maternal exposure to nitrogen dioxide (NO2), dietary intake of methyl nutrients and the odds of congenital heart defects in offspring. NO2 concentrations, a marker of traffic-related air pollution, averaged across post-conception weeks 2-8, were assigned to 6160 non-diabetic mothers of cases and controls using inverse distance-squared weighting of air monitors within 50 km of maternal residence...
May 18, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28516333/risk-of-hip-fracture-in-older-people-using-selective-serotonin-reuptake-inhibitors-and-other-psychoactive-medicines-concurrently-a-matched-case-control-study-in-australia
#17
Michael J Leach, Nicole L Pratt, Elizabeth E Roughead
BACKGROUND: Few studies have assessed the risk of hip fracture following concurrent use of psychoactive medicines, and none has investigated combinations with selective serotonin reuptake inhibitors. OBJECTIVES: To assess the risk of hip fracture in older people as a result of concurrent use of selective serotonin reuptake inhibitors and other psychoactive medicines. METHODS: A matched case-control design was employed. Cases were Australian Government Department of Veterans' Affairs beneficiaries aged over 65 years who experienced a hip fracture between 2009 and 2012...
June 2017: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/28486582/binge-drinking-modifies-the-association-between-lifetime-alcohol-intake-and-breast-cancer-risk-in-moderate-drinkers
#18
Alexandra J White, Lisa A DeRoo, Clarice R Weinberg, Dale P Sandler
The prevalence of binge drinking is rising in the United States. While alcohol is a breast cancer risk factor, less is known about the impact of episodic heavy drinking. Breast cancer-free women, ages 35-74, were enrolled in the Sister Study from 2003-2009 (n = 50,884). United States or Puerto Rico residents who had a sister with breast cancer were eligible. Multivariable Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for breast cancer. 1,843 invasive breast cancers were diagnosed during follow-up (mean = 6...
May 9, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28440717/serum-carotenoid-interactions-in-premenopausal-women-reveal-%C3%AE-carotene-is-negatively-impacted-by-body-fat
#19
Emily Taylor Nuss, Ashley R Valentine, Zhumin Zhang, HuiChuan Jennifer Lai, Sherry A Tanumihardjo
Increasing body mass indices (BMIs) across the globe reflect pandemic shifts towards habitual positive energy imbalances. Excess body fat in individuals is often associated with high-energy and high-fat diets scanty in fresh produce. Carotenoids are fat-soluble pigments plentiful in many fruits and vegetables. They are well-known for provitamin A and antioxidant functions, but little research has been done related to carotenoid-body mass interactions. Serum carotenoids were analyzed relative to body fat to determine correlations between major serum carotenoids, retinol, BMI, fat mass, and lean mass...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28421238/the-impact-of-low-education-and-poor-health-on-unemployment-varies-by-work-life-stage
#20
Sander K R van Zon, Sijmen A Reijneveld, Carlos F Mendes de Leon, Ute Bültmann
OBJECTIVES: The aim of this study is to examine associations and interactions of education, and physical and mental health with unemployment in early, mid, and late work life. METHODS: This cross-sectional study uses data from 69,118 respondents from Lifelines. Health status was measured with the RAND-36, education was self-reported, and participants working <12 h per week or indicating to be unemployed were considered unemployed. The relative excess risk due to interaction (RERI) was calculated to measure interaction on the additive scale...
April 18, 2017: International Journal of Public Health
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