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Relative excess risk due to interaction

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https://www.readbyqxmd.com/read/29321685/physical-activity-and-diet-on-atherogenic-index-of-plasma-among-adults-in-the-united-states-mediation-considerations-by-central-adiposity
#1
Meghan K Edwards, Paul D Loprinzi
BACKGROUND/OBJECTIVES: The potential interactive or combined association of moderate-to-vigorous physical activity (MVPA) and dietary behavior with atherogenic index of plasma (AIP) has yet to be explored in a representative sample of US adults. Thus, the study aim was to examine the association of MVPA and dietary behavior on AIP, with potential mediation considerations by central adiposity. SUBJECTS/METHODS: Data from the National Health and Nutrition Examination Survey were used (N = 2701 adults aged 20-85 years)...
January 10, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29206989/work-related-biomechanical-exposure-and-job-strain-as-separate-and-joint-predictors-of-musculoskeletal-diseases-a-28-year-prospective-follow-up-study
#2
K C Prakash, Subas Neupane, Päivi Leino-Arjas, Mikaela B von Bonsdorff, Taina Rantanen, Monika E von Bonsdorff, Jorma Seitsamo, Juhani Ilmarinen, Clas-Håkan Nygård
We investigated how work-related biomechanical exposure and job strain in midlife separately and jointly predicted back and degenerative musculoskeletal diseases (MSDs). A total of 6,257 employees participated in the Finnish Longitudinal Study on Aging Municipal Employees (FLAME) in 1981 and were followed up for 28 years. Risk ratios and the relative excessive risk due to interaction and 95% confidence intervals were modeled for separate and joint prediction estimates, respectively. After adjustment for confounders, job strain predicted degenerative MSDs among women after 4 and 11 years of follow-up...
December 1, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29200187/the-combined-effect-of-long-working-hours-and-low-job-control-on-self-rated-health-an-interaction-analysis
#3
Seong-Sik Cho, Young-Su Ju, Domyung Paek, Hyunjoo Kim, Kyunghee Jung-Choi
OBJECTIVES: The aim of this study was to investigate the combined effects of long working hours and low job control on self-rated health. METHODS: We analyzed employees' data obtained from the 3rd Korean Working Conditions Survey (KWCS). Multiple survey logistic analysis and post-estimation commands were employed to estimate the relative excess risk due to interaction (RERI). RESULTS: The odds ratio (OR) for poor self-rated health was 1.24 (95% confidence interval [CI]: 1...
December 1, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29175354/interaction-of-defibrillation-waveform-with-the-time-to-defibrillation-or-the-number-of-defibrillation-attempts-on-survival-from-out-of-hospital-cardiac-arrest
#4
Akihito Hagihara, Daisuke Onozuka, Junko Ono, Takashi Nagata, Manabu Hasegawa
AIM: Early biphasic defibrillation is effective in out-of-hospital cardiac arrest (OHCA) cases. In the resuscitation of patients with OHCA, it is not clear how the defibrillation waveform interacts with the time to defibrillation to influence patient survival. The second, and any subsequent, shocks need to be administered by an on-line physician in Japan. Thus, we investigated the interaction between the defibrillation waveform and time to or the number of defibrillation on resuscitation outcomes...
November 24, 2017: Resuscitation
https://www.readbyqxmd.com/read/29154418/measuring-non-polyaminated-lipocalin-2-for-cardiometabolic-risk-assessment
#5
Kangmin Yang, Han-Bing Deng, Andy W C Man, Erfei Song, Jialiang Zhang, Cuiting Luo, Bernard M Y Cheung, Kwok-Yung Yuen, Pia Søndergaard Jensen, Akhmadjon Irmukhamedov, Atlanta G I M Elie, Paul M Vanhoutte, Aimin Xu, Jo G R De Mey, Yu Wang
AIMS: Lipocalin-2 is a pro-inflammatory molecule characterized by a highly diversified pattern of expression and structure-functional relationships. In vivo, this molecule exists as multiple variants due to post-translational modifications and/or protein-protein interactions. Lipocalin-2 is modified by polyamination, which enhances the clearance of this protein from the circulation and prevents its excessive accumulation in tissues. On the other hand, animal studies suggest that non-polyaminated lipocalin-2 (npLcn2) plays a causal role in the pathogenesis of obesity-associated medical complications...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29153857/predicting-the-atopic-march-results-from-the-canadian-healthy-infant-longitudinal-development-study
#6
Maxwell M Tran, Diana L Lefebvre, Christoffer Dharma, David Dai, Wendy Y W Lou, Padmaja Subbarao, Allan B Becker, Piush J Mandhane, Stuart E Turvey, Malcolm R Sears
BACKGROUND: The atopic march describes the progression from atopic dermatitis during infancy to asthma and allergic rhinitis in later childhood. In a Canadian birth cohort we investigated whether concomitant allergic sensitization enhances subsequent development of these allergic diseases at age 3 years. METHODS: Children completed skin prick testing at age 1 year. Children were considered sensitized if they produced a wheal 2 mm or larger than that elicited by the negative control to any of 10 inhalant or food allergens...
November 1, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29140924/the-association-between-pain-and-frailty-among-chinese-community-dwelling-older-adults-depression-as-a-mediator-and-its-interaction-with-pain
#7
Xiaoyu Tian, Cuili Wang, Xiaoxia Qiao, Na Liu, Lijuan Dong, Mary Butler, Huaxin Si, Yaru Jin
Pain and frailty are both prevalent and have severe health impacts among older adults. We conducted a cross-sectional observational study to examine the association between pain and frailty, and depression as a mediator and its interaction with pain on frailty among 1788 Chinese community-dwelling older adults. Physical frailty, pain intensity and depressive symptoms were assessed using the Frailty Phenotype, the revised Faces Pain Scale (FPS-R), and the 5-item Geriatric Depression Scale (GDS-5), respectively...
November 13, 2017: Pain
https://www.readbyqxmd.com/read/29127522/common-genetic-variation-within-mir-146a-predicts-disease-onset-and-relapse-in-multiple-sclerosis
#8
Yuan Zhou, Ming Chen, Steve Simpson, Robyn M Lucas, Jac C Charlesworth, Nicholas Blackburn, Ingrid van der Mei, Anne-Louise Ponsonby, Bruce V Taylor
Despite extensive studies focusing on the changes in expression of microRNAs (miRNAs) in multiple sclerosis (MS) compared to healthy controls, few studies have evaluated the association of genetic variants of miRNAs with MS clinical course. We investigated whether a functional polymorphism in the MS associated miR-146a gene predicted clinical course (hazard of conversion to MS and of relapse, and annualized change in disability), using a longitudinal cohort study of persons with a first demyelinating event followed up to their 5-year review...
November 10, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29124871/low-triglyceride-as-a-marker-for-increased-risk-of-cardiovascular-diseases-in-patients-with-long-term-type-2-diabetes-a-cross-sectional-survey-in-china
#9
Yanfeng Ren, Qian Ren, Juming Lu, Xiaohui Guo, Xiaoxu Huo, Linong Ji, Xilin Yang
BACKGROUND: There are inconsistent findings regarding associations between triglyceride and cardiovascular disease (CVD) in type 2 diabetes mellitus (T2DM). This study aimed to test whether the association between triglyceride and CVD depends upon duration of diabetes. METHODS: From April 1, 2012 to June 30, 2012, we conducted a cross-sectional survey of 223612 patients with T2DM from 630 hospitals in China. CVD was defined as having either prior coronary heart disease or stroke or diabetes foot...
November 9, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29092779/research-long-exposure-to-type-2-diabetes-and-risk-of-non-fatal-coronary-heart-disease-in-chinese-females-and-males-findings-from-a-china-national-cross-sectional-study
#10
Jing Li, Yingying Luo, Xiaohui Guo, Xiaoxu Huo, Juming Lu, Yanfeng Ren, Linong Ji, Xilin Yang
AIMS: To investigate the risk of Chinese females versus males for non-fatal coronary heart disease (CHD) due to long exposure to type 2 diabetes mellitus (T2DM). METHODS: 223,612 Chinese patients with T2DM were recruited from China in 2012. Binary logistic regression analysis was performed to obtain odds ratios (OR) of females versus males for non-fatal CHD. Additive interaction was used to test whether female gender and long exposure to T2DM (≥15 years) had a synergistic effect for non-fatal CHD...
October 29, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29068365/interplay-of-socioeconomic-status-and-supermarket-distance-is-associated-with-excess-obesity-risk-a-uk-cross-sectional-study
#11
Thomas Burgoine, Joreintje D Mackenbach, Jeroen Lakerveld, Nita G Forouhi, Simon J Griffin, Søren Brage, Nicholas J Wareham, Pablo Monsivais
U.S. policy initiatives have sought to improve health through attracting neighborhood supermarket investment. Little evidence exists to suggest that these policies will be effective, in particular where there are socioeconomic barriers to healthy eating. We measured the independent associations and combined interplay of supermarket access and socioeconomic status with obesity. Using data on 9702 UK adults, we employed adjusted regression analyses to estimate measured BMI (kg/m²), overweight (25 ≥ BMI < 30) and obesity (≥30), across participants' highest educational attainment (three groups) and tertiles of street network distance (km) from home location to nearest supermarket...
October 25, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29057550/in-vitro-magnetic-resonance-imaging-evaluation-of-fragmented-open-coil-percutaneous-peripheral-nerve-stimulation-leads
#12
Frank G Shellock, Armaan Zare, Brian M Ilfeld, John Chae, Robert B Strother
OBJECTIVE: Percutaneous peripheral nerve stimulation (PNS) is an FDA-cleared pain treatment. Occasionally, fragments of the lead (MicroLead, SPR Therapeutics, LLC, Cleveland, OH, USA) may be retained following lead removal. Since the lead is metallic, there are associated magnetic resonance imaging (MRI) risks. Therefore, the objective of this investigation was to evaluate MRI-related issues (i.e., magnetic field interactions, heating, and artifacts) for various lead fragments. METHODS: Testing was conducted using standardized techniques on lead fragments of different lengths (i...
October 23, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29020407/does-obesity-along-with-major-depression-or-anxiety-lead-to-higher-use-of-health-care-and-costs-a-6-year-follow-up-study
#13
Yeshambel T Nigatu, Ute Bültmann, Robert A Schoevers, Brenda W J H Penninx, Sijmen A Reijneveld
Background: Evidence lacks on whether obesity along with major depression (MD)/anxiety leads to higher health care use (HCU) and health care-related costs (HCC) compared with either condition alone. The objective of the study was to examine the longitudinal associations of obesity, MD/anxiety, and their combination with HCU and HCC. Methods: Longitudinal data (2004-2013) among N = 2706 persons at baseline and 2-,4-, and 6-year follow-up were collected on obesity, MD/anxiety and HCU...
September 11, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28973051/interaction-between-awake-and-sleep-bruxism-is-associated-with-increased-presence-of-painful-temporomandibular-disorder
#14
Daniel R Reissmann, Mike T John, Annette Aigner, Gerhard Schön, Ira Sierwald, Eric L Schiffman
AIMS: To explore whether awake and sleep bruxism interact in their associations with painful temporomandibular disorders (TMD) and whether the interaction is multiplicative or additive. METHODS: In this case-control study, all participants (n = 705) were part of the multicenter Validation Project and were recruited as a convenience sample of community cases and controls and clinic cases. Logistic regression analyses were applied to test for the association between self-reported bruxism (sleep and/or awake) and the presence of painful TMD, and odds ratios (ORs) with 95% confidence intervals (95% CIs) were computed...
2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28950191/interactions-of-physical-activity-and-body-mass-index-with-age-at-menarche-a-school-based-sample-of-chinese-female-adolescents
#15
Chao Xing, Zhaohui Huang, Jie Li, Ming Li, Laichao Xu, Jianhua Tao, Lijun Fu, Yirong Fang
BACKGROUND: To test the independent and interactive associations of physical activity (PA) and body mass index (BMI) with age at menarche among Chinese adolescence. METHODS: We conducted a cross-sectional survey in two elementary schools in September 2015 in Shaoxing city, Zhejiang province, China. We used self-administered questionnaires to collect the information of the participators. Analyses were performed with logistic regression models, and the relative excess risk due to interaction (RERI), the attributable proportion because of the interaction (AP), and the synergy index (S) were used to evaluate the biological interaction...
November 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28942612/interactions-of-homocysteine-and-conventional-predisposing-factors-on-hypertension-in-chinese-adults
#16
Boyi Yang, Shujun Fan, Xueyuan Zhi, Jing He, Ping Ma, Luyang Yu, Quanmei Zheng, Guifan Sun
This study aimed to investigate whether conventional predisposing factors modify the associations of homocysteine with blood pressure levels and hypertension. A total of 2615 adults were recruited from Liaoning province. An elevated homocysteine level was significantly associated with increased hypertension risk and blood pressure (all P<.05). Interaction analyses showed that homocysteine acted synergistically with age, overweight/obesity, dyslipidemia, and family history of hypertension to affect hypertension risk, and the relative excess risk due to interaction was 1...
November 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28940138/the-risk-of-hip-fracture-due-to-mirtazapine-exposure-when-switching-antidepressants-or-using-other-antidepressants-as-add-on-therapy
#17
Michael J Leach, Nicole L Pratt, Elizabeth E Roughead
BACKGROUND: Antidepressants are associated with adverse effects such as sedation and hypotension, which can result in falls and fractures. Few studies have assessed the risk of hip fracture due to mirtazapine, and no known studies have assessed whether the risk of hip fracture is higher in patients taking other antidepressant medicines in combination with mirtazapine. OBJECTIVES: This study aimed to examine the risk of hip fracture in older people due to mirtazapine use as well as switching between or concurrently using mirtazapine and other antidepressants...
December 2017: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/28833953/mixed-state-and-suicide-is-the-effect-of-mixed-state-on-suicidal-behavior-more-than-the-sum-of-its-parts
#18
Jane E Persons, William H Coryell, David A Solomon, Martin B Keller, Jean Endicott, Jess G Fiedorowicz
OBJECTIVE: To assess whether suicidal behavior during mixed states exceeds that expected from the manic or depressive components alone. METHODS: This study included 429 participants with bipolar disorder from the National Institute of Mental Health Collaborative Depression Study (CDS). Mood and suicidal behavior were captured using the Longitudinal Interval Follow-up Evaluation and the Schedule of Affective Disorders and Schizophrenia. Suicidal behavior during each mood state, relative to euthymia, was analyzed using Cox regression to allow for repeated events, with a frailty term to account for intra-participant correlation...
August 23, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28790041/impact-of-nutritional-index-on-the-association-between-phosphorus-concentrations-and-mortality-in-haemodialysis-patients-a-cohort-study-from-dialysis-outcomes-and-practice-pattern-study-in-japan
#19
Shingo Fukuma, Tatsuyoshi Ikenoue, Tadao Akizawa, Shunichi Fukuhara
OBJECTIVES: While maintenance of both phosphorus concentration and nutritional status is a major concern in managing haemodialysis patients, the interaction between these parameters is not well understood. The aim of this study was to assess whether or not nutritional index influences the association between phosphorus concentration and all-cause mortality. DESIGN: A cohort study. SETTING: The Dialysis Outcomes and Practice Pattern Study, which included 99 representative dialysis facilities in Japan between 1997 and 2010...
August 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28764134/exposure-to-polycyclic-aromatic-hydrocarbons-and-central-obesity-enhanced-risk-for-diabetes-among-individuals-with-poor-lung-function
#20
Jian Hou, Huizhen Sun, Xiji Huang, Yun Zhou, Youjian Zhang, Wenjun Yin, Tian Xu, Juan Cheng, Weihong Chen, Jing Yuan
Some studies have shown an association between obesity or exposure to polycyclic aromatic hydrocarbons (PAHs) and the risk of diabetes. This study aimed to investigate the interaction of obesity and urinary monohydroxy-PAHs (OH-PAHs) on diabetes. Individuals (n = 2716) were drawn from the baseline survey of the Wuhan-Zhuhai Cohort Study. They completed the physical examination, measurements of lung function, biochemical indices and urinary OH-PAHs levels. Additive effect of obesity and urinary ΣOH-PAHs levels on diabetes was assessed by calculating the relative excess risk due to interaction (RERI) and the attributable proportion (AP) due to interaction...
October 2017: Chemosphere
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