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Relative excess risk due to interaction

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https://www.readbyqxmd.com/read/29140924/the-association-between-pain-and-frailty-among-chinese-community-dwelling-older-adults-depression-as-a-mediator-and-its-interaction-with-pain
#1
Xiaoyu Tian, Cuili Wang, Xiaoxia Qiao, Na Liu, Lijuan Dong, Mary Butler, Huaxin Si, Yaru Jin
Pain and frailty are both prevalent and have severe health impacts among older adults. We conducted a cross-sectional observational study to examine the association between pain and frailty, and depression as a mediator and its interaction with pain on frailty among 1788 Chinese community-dwelling older adults. Physical frailty, pain intensity and depressive symptoms were assessed using the Frailty Phenotype, the revised Faces Pain Scale (FPS-R), and the 5-item Geriatric Depression Scale (GDS-5), respectively...
November 13, 2017: Pain
https://www.readbyqxmd.com/read/29127522/common-genetic-variation-within-mir-146a-predicts-disease-onset-and-relapse-in-multiple-sclerosis
#2
Yuan Zhou, Ming Chen, Steve Simpson, Robyn M Lucas, Jac C Charlesworth, Nicholas Blackburn, Ingrid van der Mei, Anne-Louise Ponsonby, Bruce V Taylor
Despite extensive studies focusing on the changes in expression of microRNAs (miRNAs) in multiple sclerosis (MS) compared to healthy controls, few studies have evaluated the association of genetic variants of miRNAs with MS clinical course. We investigated whether a functional polymorphism in the MS associated miR-146a gene predicted clinical course (hazard of conversion to MS and of relapse, and annualized change in disability), using a longitudinal cohort study of persons with a first demyelinating event followed up to their 5-year review...
November 10, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29124871/low-triglyceride-as-a-marker-for-increased-risk-of-cardiovascular-diseases-in-patients-with-long-term-type-2-diabetes-a-cross-sectional-survey-in-china
#3
Yanfeng Ren, Qian Ren, Juming Lu, Xiaohui Guo, Xiaoxu Huo, Linong Ji, Xilin Yang
BACKGROUND: There are inconsistent findings regarding associations between triglyceride and cardiovascular disease (CVD) in type 2 diabetes mellitus (T2DM). This study aimed to test whether the association between triglyceride and CVD depends upon duration of diabetes. METHODS: From April 1, 2012 to June 30, 2012, we conducted a cross-sectional survey of 223612 patients with T2DM from 630 hospitals in China. CVD was defined as having either prior coronary heart disease or stroke or diabetes foot...
November 9, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29092779/research-long-exposure-to-type-2-diabetes-and-risk-of-non-fatal-coronary-heart-disease-in-chinese-females-and-males-findings-from-a-china-national-cross-sectional-study
#4
Jing Li, Yingying Luo, Xiaohui Guo, Xiaoxu Huo, Juming Lu, Yanfeng Ren, Linong Ji, Xilin Yang
AIMS: To investigate the risk of Chinese females versus males for non-fatal coronary heart disease (CHD) due to long exposure to type 2 diabetes mellitus (T2DM). METHODS: 223,612 Chinese patients with T2DM were recruited from China in 2012. Binary logistic regression analysis was performed to obtain odds ratios (OR) of females versus males for non-fatal CHD. Additive interaction was used to test whether female gender and long exposure to T2DM (≥15 years) had a synergistic effect for non-fatal CHD...
October 29, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29068365/interplay-of-socioeconomic-status-and-supermarket-distance-is-associated-with-excess-obesity-risk-a-uk-cross-sectional-study
#5
Thomas Burgoine, Joreintje D Mackenbach, Jeroen Lakerveld, Nita G Forouhi, Simon J Griffin, Søren Brage, Nicholas J Wareham, Pablo Monsivais
U.S. policy initiatives have sought to improve health through attracting neighborhood supermarket investment. Little evidence exists to suggest that these policies will be effective, in particular where there are socioeconomic barriers to healthy eating. We measured the independent associations and combined interplay of supermarket access and socioeconomic status with obesity. Using data on 9702 UK adults, we employed adjusted regression analyses to estimate measured BMI (kg/m²), overweight (25 ≥ BMI < 30) and obesity (≥30), across participants' highest educational attainment (three groups) and tertiles of street network distance (km) from home location to nearest supermarket...
October 25, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29057550/in-vitro-magnetic-resonance-imaging-evaluation-of-fragmented-open-coil-percutaneous-peripheral-nerve-stimulation-leads
#6
Frank G Shellock, Armaan Zare, Brian M Ilfeld, John Chae, Robert B Strother
OBJECTIVE: Percutaneous peripheral nerve stimulation (PNS) is an FDA-cleared pain treatment. Occasionally, fragments of the lead (MicroLead, SPR Therapeutics, LLC, Cleveland, OH, USA) may be retained following lead removal. Since the lead is metallic, there are associated magnetic resonance imaging (MRI) risks. Therefore, the objective of this investigation was to evaluate MRI-related issues (i.e., magnetic field interactions, heating, and artifacts) for various lead fragments. METHODS: Testing was conducted using standardized techniques on lead fragments of different lengths (i...
October 23, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29020407/does-obesity-along-with-major-depression-or-anxiety-lead-to-higher-use-of-health-care-and-costs-a-6-year-follow-up-study
#7
Yeshambel T Nigatu, Ute Bültmann, Robert A Schoevers, Brenda W J H Penninx, Sijmen A Reijneveld
Background: Evidence lacks on whether obesity along with major depression (MD)/anxiety leads to higher health care use (HCU) and health care-related costs (HCC) compared with either condition alone. The objective of the study was to examine the longitudinal associations of obesity, MD/anxiety, and their combination with HCU and HCC. Methods: Longitudinal data (2004-2013) among N = 2706 persons at baseline and 2-,4-, and 6-year follow-up were collected on obesity, MD/anxiety and HCU...
September 11, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28973051/interaction-between-awake-and-sleep-bruxism-is-associated-with-increased-presence-of-painful-temporomandibular-disorder
#8
Daniel R Reissmann, Mike T John, Annette Aigner, Gerhard Schön, Ira Sierwald, Eric L Schiffman
AIMS: To explore whether awake and sleep bruxism interact in their associations with painful temporomandibular disorders (TMD) and whether the interaction is multiplicative or additive. METHODS: In this case-control study, all participants (n = 705) were part of the multicenter Validation Project and were recruited as a convenience sample of community cases and controls and clinic cases. Logistic regression analyses were applied to test for the association between self-reported bruxism (sleep and/or awake) and the presence of painful TMD, and odds ratios (ORs) with 95% confidence intervals (95% CIs) were computed...
2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28950191/interactions-of-physical-activity-and-body-mass-index-with-age-at-menarche-a-school-based-sample-of-chinese-female-adolescents
#9
Chao Xing, Zhaohui Huang, Jie Li, Ming Li, Laichao Xu, Jianhua Tao, Lijun Fu, Yirong Fang
BACKGROUND: To test the independent and interactive associations of physical activity (PA) and body mass index (BMI) with age at menarche among Chinese adolescence. METHODS: We conducted a cross-sectional survey in two elementary schools in September 2015 in Shaoxing city, Zhejiang province, China. We used self-administered questionnaires to collect the information of the participators. Analyses were performed with logistic regression models, and the relative excess risk due to interaction (RERI), the attributable proportion because of the interaction (AP), and the synergy index (S) were used to evaluate the biological interaction...
September 20, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28942612/interactions-of-homocysteine-and-conventional-predisposing-factors-on-hypertension-in-chinese-adults
#10
Boyi Yang, Shujun Fan, Xueyuan Zhi, Jing He, Ping Ma, Luyang Yu, Quanmei Zheng, Guifan Sun
This study aimed to investigate whether conventional predisposing factors modify the associations of homocysteine with blood pressure levels and hypertension. A total of 2615 adults were recruited from Liaoning province. An elevated homocysteine level was significantly associated with increased hypertension risk and blood pressure (all P<.05). Interaction analyses showed that homocysteine acted synergistically with age, overweight/obesity, dyslipidemia, and family history of hypertension to affect hypertension risk, and the relative excess risk due to interaction was 1...
November 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28940138/the-risk-of-hip-fracture-due-to-mirtazapine-exposure-when-switching-antidepressants-or-using-other-antidepressants-as-add-on-therapy
#11
Michael J Leach, Nicole L Pratt, Elizabeth E Roughead
BACKGROUND: Antidepressants are associated with adverse effects such as sedation and hypotension, which can result in falls and fractures. Few studies have assessed the risk of hip fracture due to mirtazapine, and no known studies have assessed whether the risk of hip fracture is higher in patients taking other antidepressant medicines in combination with mirtazapine. OBJECTIVES: This study aimed to examine the risk of hip fracture in older people due to mirtazapine use as well as switching between or concurrently using mirtazapine and other antidepressants...
December 2017: Drugs—Real World Outcomes
https://www.readbyqxmd.com/read/28833953/mixed-state-and-suicide-is-the-effect-of-mixed-state-on-suicidal-behavior-more-than-the-sum-of-its-parts
#12
Jane E Persons, William H Coryell, David A Solomon, Martin B Keller, Jean Endicott, Jess G Fiedorowicz
OBJECTIVE: To assess whether suicidal behavior during mixed states exceeds that expected from the manic or depressive components alone. METHODS: This study included 429 participants with bipolar disorder from the National Institute of Mental Health Collaborative Depression Study (CDS). Mood and suicidal behavior were captured using the Longitudinal Interval Follow-up Evaluation and the Schedule of Affective Disorders and Schizophrenia. Suicidal behavior during each mood state, relative to euthymia, was analyzed using Cox regression to allow for repeated events, with a frailty term to account for intra-participant correlation...
August 23, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28790041/impact-of-nutritional-index-on-the-association-between-phosphorus-concentrations-and-mortality-in-haemodialysis-patients-a-cohort-study-from-dialysis-outcomes-and-practice-pattern-study-in-japan
#13
Shingo Fukuma, Tatsuyoshi Ikenoue, Tadao Akizawa, Shunichi Fukuhara
OBJECTIVES: While maintenance of both phosphorus concentration and nutritional status is a major concern in managing haemodialysis patients, the interaction between these parameters is not well understood. The aim of this study was to assess whether or not nutritional index influences the association between phosphorus concentration and all-cause mortality. DESIGN: A cohort study. SETTING: The Dialysis Outcomes and Practice Pattern Study, which included 99 representative dialysis facilities in Japan between 1997 and 2010...
August 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/28764134/exposure-to-polycyclic-aromatic-hydrocarbons-and-central-obesity-enhanced-risk-for-diabetes-among-individuals-with-poor-lung-function
#14
Jian Hou, Huizhen Sun, Xiji Huang, Yun Zhou, Youjian Zhang, Wenjun Yin, Tian Xu, Juan Cheng, Weihong Chen, Jing Yuan
Some studies have shown an association between obesity or exposure to polycyclic aromatic hydrocarbons (PAHs) and the risk of diabetes. This study aimed to investigate the interaction of obesity and urinary monohydroxy-PAHs (OH-PAHs) on diabetes. Individuals (n = 2716) were drawn from the baseline survey of the Wuhan-Zhuhai Cohort Study. They completed the physical examination, measurements of lung function, biochemical indices and urinary OH-PAHs levels. Additive effect of obesity and urinary ΣOH-PAHs levels on diabetes was assessed by calculating the relative excess risk due to interaction (RERI) and the attributable proportion (AP) due to interaction...
October 2017: Chemosphere
https://www.readbyqxmd.com/read/28763915/-pickled-food-fish-seafood-intakes-and-oral-squamous-cell-carcinoma-a-case-control-study
#15
J F Huang, Y Qiu, L Cai, F P Liu, F Chen, L J Yan, J F Wu, X D Bao, F Q Liu, X Y Zheng, L S Lin, B C He
Objective: To investigate the effects between fish, seafood and pickled food intakes on oral squamous cell carcinoma (OSCC). Methods: A case-control study was carried out in Fujian area during September 2010 to December 2016, in which 604 newly diagnosed primary OSCC cases confirmed by pathological diagnosis were collected from hospital and 1 343 control subjects were enrolled from community and healthy hospital population. Demographic data, history of smoking drinking and tea drinking, oral hygiene status and dietary behaviors (fish, seafood and pickled food intakes) were collected by in-person interviews using a standard questionnaire...
August 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28755257/two-way-interaction-effects-of-perioperative-complications-on-30-day-mortality-in-general-surgery
#16
Minjae Kim, Guohua Li
BACKGROUND: Multiple perioperative complications increase mortality risk, and certain complications synergistically increase this risk to a greater degree than might be expected if the complications were independent, but these effects are not well established. METHODS: This is a retrospective cohort study of 422,827 intraabdominal general surgery patients (American College of Surgeons National Surgical Quality Improvement Program 2005-2011). Eight complications were evaluated: acute respiratory failure (ARF), acute kidney injury (AKI), sepsis/septic shock, stroke, cardiac arrest (CA), myocardial infarction (MI), deep vein thrombosis/pulmonary embolus, and transfusion...
July 28, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28737433/association-and-interaction-between-triglyceride-glucose-index-and-obesity-on-risk-of-hypertension-in-middle-aged-and-elderly-adults
#17
Song Jian, Nie Su-Mei, Chen Xue, Zhang Jie, Wu Xue-Sen
AIMS: To investigate the association between triglyceride-glucose(TyG) index and the risk of hypertension. METHOD: A cross-sectional study was conducted in Bengbu, China. The participants received relevant questionnaire survey, anthropometric tests, and laboratory examination. Multivariate logistic regression analysis was performed to estimate the possible association between TyG index and hypertension risk. The additive interaction evaluated by the relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), and synergy index(SI) was calculated...
July 24, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28701338/lifestyle-in-progression-from-hypertensive-disorders-of-pregnancy-to-chronic-hypertension-in-nurses-health-study-ii-observational-cohort-study
#18
Simon Timpka, Jennifer J Stuart, Lauren J Tanz, Eric B Rimm, Paul W Franks, Janet W Rich-Edwards
Objectives To study the association between lifestyle risk factors and chronic hypertension by history of hypertensive disorders of pregnancy (HDP: gestational hypertension and pre-eclampsia) and investigate the extent to which these risk factors modify the association between HDP and chronic hypertension.Design Prospective cohort study.Setting Nurses' Health Study II (1991-2013).Participants 54 588 parous women aged 32 to 59 years with data on reproductive history and without previous chronic hypertension, stroke, or myocardial infarction...
July 12, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28666636/high-hepatitis-c-incidence-in-relation-to-prescription-opioid-injection-and-poly-drug-use-assessing-barriers-to-hepatitis-c-prevention
#19
Svetlana Puzhko, Élise Roy, Didier Jutras-Aswad, Andreea Adelina Artenie, Emmanuel Fortier, Geng Zang, Julie Bruneau
BACKGROUND: Prescription opioid (PO) injection and poly-drug use have been associated with hepatitis C virus (HCV) infection among people who inject drugs (PWID). Poly-drug use is often a barrier to key HCV preventive programmes including opioid agonist treatment. The contribution of specific drug combinations to high HCV incidence in poly-drug users has not been assessed previously. Addressing this knowledge gap could enhance HCV treatment and prevention efforts. We examined the association between specific drugs and number of drugs used in addition to injected POs, and HCV seroconversion...
September 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28664715/the-history-of-arsenical-pesticides-and-health-risks-related-to-the-use-of-agent-blue
#20
Vladimir Bencko, Florence Yan Li Foong
Arsenicals in agriculture. Beginning in the 1970s, the use of arsenic compounds for such purposes as wood preservatives, began to grow. By 1980, in the USA, 70% of arsenic had been consumed for the production of wood preservatives. This practice was later stopped, due to the US Environmental Protection Agency (EPA) ban of the arsenic-and chromium-based wood preservative chromated copper arsenate. In the past, arsenical herbicides containing cacodylic acid as an active ingredient have been used extensively in the USA, from golf courses to cotton fields, and drying-out the plants before harvesting...
June 12, 2017: Annals of Agricultural and Environmental Medicine: AAEM
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