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Yubao Lv, Linuo Zhou, Zihui Tang, Jingcheng Dong
BACKGROUND: This study assessed the extent to which diabetes mellitus (DM) and SCN10A (rs7375036) and their interaction impact on cardiovascular autonomic neuropathy (CAN) susceptibility in a Chinese Han sample. METHOD: We performed a study in a cross-sectional dataset that included 419 patients with DM and 1557 controls who were genotyped for the presence of the SCN10A rs7375036 polymorphisms. Genotyping was performed by iPLEX technology. The associations of rs7375036 and DM with CAN was assessed by using univariate and multivariate logistic regression controlling for confounders...
October 11, 2016: Postgraduate Medical Journal
Tetyana Kendzerska, Richard S Leung, Andrea S Gershon, George Tomlinson, Najib Ayas
RATIONALE: The inter-relationships between obstructive sleep apnea (OSA) and obesity are complex and bidirectional; however, the current evidence regarding their combined effect o cardiovascular risk is limited and conflicting. Animal studies suggest that obesity may exacerbate the cardiovascular consequences of intermittent hypoxemia. OBJECTIVES: In this historical observational study, we investigated whether obesity increases the effect of nocturnal hypoxemia on the incidence of cardiovascular events in adults with suspected OSA...
September 30, 2016: Annals of the American Thoracic Society
Junhong Leng, Peng Wang, Ping Shao, Cuiping Zhang, Weiqin Li, Nan Li, Leishen Wang, Hairong Nan, Zhijie Yu, Gang Hu, Juliana Cn Chan, Xilin Yang
BACKGROUND: Passive smoking increased type 2 diabetes mellitus risk but it is uncertain whether it also increased gestational diabetes mellitus (GDM) risk. We aimed to examine the association of passive smoking during pregnancy and its interaction with maternal obesity for GDM. METHODS: From 2010 to 2012, 12,786 Chinese women underwent a 50-gram 1-hour glucose challenge test (GCT) at 24-28 weeks of gestation and further underwent a 75-gram 2-hour oral glucose tolerance test if the GCT result was ≥7...
September 26, 2016: Diabetes/metabolism Research and Reviews
Kjetil Bjørnevik, Trond Riise, Inger Bostrom, Llaria Casetta, Marianna Cortese, Enrico Granieri, Trygve Holmøy, Margitta T Kampman, Anne-Marie Landtblom, Sandra Magalhaes, Maura Pugliatti, Christina Wolfson, Kjell-Morten Myhr
BACKGROUND: Results from previous studies on a possible interaction between smoking and Epstein-Barr virus (EBV) in the risk of multiple sclerosis (MS) are conflicting. OBJECTIVES: To examine the interaction between smoking and infectious mononucleosis (IM) in the risk of MS. METHODS: Within the case-control study on Environmental Factors In Multiple Sclerosis (EnvIMS), 1904 MS patients and 3694 population-based frequency-matched healthy controls from Norway, Italy, and Sweden reported on prior exposure to smoking and history of IM...
September 23, 2016: Multiple Sclerosis: Clinical and Laboratory Research
Guangyun Mao, Rebecca Massa Nachman, Qi Sun, Xingyou Zhang, Kirsten Koehler, Zhu Chen, Xiumei Hong, Guoying Wang, Deanna Caruso, Geng Zong, Colleen Pearson, Hongkai Ji, Shyam Biswal, Barry Zuckerman, Marsha Wills-Karp, Xiaobin Wang
BACKGROUND: Although previous studies suggest that exposure to traffic-related pollution during childhood increases risk of childhood overweight or obesity (COWO), the role of early-life exposure to fine particulate matter (aerodynamic diameter <2.5 micrometers, PM2.5) and its joint effect with mother's pre-pregnancy body mass index (MPBMI) on COWO remain unclear. OBJECTIVES: The present study was conducted to examine the individual and joint effects of ambient PM2...
September 16, 2016: Environmental Health Perspectives
Fangfang Zeng, Linuo Zhou, Zihui Tang
BACKGROUND: The aim of this study was to investigate the association and interaction of metabolic syndrome (MetS) and estrogen receptor alpha 1 (ESR1) gene polymorphisms on cardiovascular autonomic neuropathy (CAN). METHODS: A large-scale, population-based study was conducted to analyze the interaction of MetS and ESR1 gene polymorphisms to CAN, including a total of 1977 Chinese subjects. The most common studied single nucleotide polymorphism of ESR1 gene-rs9340799, was genotyped...
2016: Diabetology & Metabolic Syndrome
H X Wen, F Zhang, T Wang, B Wang, X F Wang, X X Xu, Z D Fu, J Guo, L R Zhang, Y Gao, B Wang, S P Wang
OBJECTIVE: To investigate the relationship between HBeAg status, mode of delivery and intrauterine transmission of the HBsAg-positive mothers as well as their interactions. METHODS: A total of 344 HBsAg-positive pregnant women and their infants were enrolled in this study. The mothers were recruited from the Third People's Hospital of Taiyuan, from July 2011 to January 2013. Serum HBV-M and HBV DNA were measured using the electro-chemiluminescence immune-assay (ECLIA) kits and fluorescene quantitative polymerase chain reaction (FQ-PCR) assay, respectively...
June 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
Mohammad Hossein Jabbarpoor Bonyadi, Mehdi Yaseri, Mortaza Bonyadi, Masoud Soheilian, Saeed Karimi
PURPOSE: Complement factor H (CFH) Y402H (rs1061170) and age-related maculopathy susceptibility2 (ARMS2)/LOC387715 A69S (rs10490924) polymorphisms shown to have significant association with age-related macular degeneration (AMD). In this meta-analysis, we pooled the results of the available association studies between combined ARMS2/LOC387715A69S-CFHY402H genotypes and AMD to estimate the possible synergistic or multiplicative effects. METHODS: Heterogeneity of studies was evaluated using the Cochran Q-test and the I-square index...
June 7, 2016: Current Eye Research
Daniel Medenwald, Cees A Swenne, Harald Loppnow, Jan A Kors, Diana Pietzner, Daniel Tiller, Joachim Thiery, Sebastian Nuding, Karin H Greiser, Johannes Haerting, Karl Werdan, Alexander Kluttig
AIMS: To determine the interaction between HRV and inflammation and their association with cardiovascular/all-cause mortality in the general population. METHODS AND RESULTS: Subjects of the CARLA study (n = 1671; 778 women, 893 men, 45-83 years of age) were observed for an average follow-up period of 8.8 years (226 deaths, 70 cardiovascular deaths). Heart rate variability parameters were calculated from 5-min segments of 20-min resting electrocardiograms. High-sensitivity C-reactive protein (hsCRP), interleukin-6 (IL-6), and soluble tumour necrosis factor-alpha receptor type 1 (sTNF-R1) were measured as inflammation parameters...
May 24, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Thomas Burgoine, Nita G Forouhi, Simon J Griffin, Søren Brage, Nicholas J Wareham, Pablo Monsivais
BACKGROUND: Greater exposures to fast-food outlets and lower levels of education are independently associated with less healthy diets and obesity. Little is known about the interplay between these environmental and individual factors. OBJECTIVE: The purpose of this study was to test whether observed differences in fast-food consumption and obesity by fast-food outlet exposure are moderated by educational attainment. DESIGN: In a population-based cohort of 5958 adults aged 29-62 y in Cambridgeshire, United Kingdom, we used educational attainment-stratified regression models to estimate the food-frequency questionnaire-derived consumption of energy-dense "fast foods" (g/d) typically sold in fast-food restaurants and measured body mass index (BMI; in kg/m(2)) across geographic information system-derived home and work fast-food exposure quartiles...
June 2016: American Journal of Clinical Nutrition
Karla Dala Paula Torres, Maria Luiza Garcia Rosa, Samuel Datum Moscavitch
Obesity impacts the quality of life (HRQL). Studies about the effects of a possible interaction between gender and body mass are rare. The objective of the present paper is to estimate the biological interaction between gender and obesity on HRQL. This was a cross-sectional study based on data from CAMELIA study with population assisted by the Family Doctor Program of Niteroi visited between June 2006 and December 2007. HRQL was assessed by the SF-36. The exposure categories were: obese women, non-obese women, obese men and non-obese men, the reference category...
May 2016: Ciência & Saúde Coletiva
Jian Hou, Huizhen Sun, Lili Xiao, Yun Zhou, Wenjun Yin, Tian Xu, Juan Cheng, Weihong Chen, Jing Yuan
Associations of type 2 diabetes with exposure to polycyclic aromatic hydrocarbons and reduced lung function have been reported. The aim of the present study was to investigate effect of reduced lung function and exposure to background PAHs on diabetes. A total of 2730 individuals were drawn from the Wuhan-Zhuhai (WHZH) Cohort Study (n=3053). Participants completed physical examination, measurement of lung function and urinary monohydroxylated polycyclic aromatic hydrocarbons (OH-PAHs). Risk factors for type 2 diabetes were identified by multiple logistic regression analysis, and the presence of additive interaction between levels of urinary OH-PAHs and lower lung function was evaluated by calculation of the relative excess risk due to interaction (RERI) and attributable proportion due to interaction (AP)...
July 2016: Environmental Research
Peian Lou, Peipei Chen, Pan Zhang, Jiaxi Yu, Yong Wang, Na Chen, Lei Zhang, Hongmin Wu, Jing Zhao
BACKGROUND: Depression and smoking decrease health status in Chronic Obstructive Pulmonary Disease (COPD), but the combined effect of the two factors is unknown. This study aimed to assess the interactive effects of depression and smoking on the severity of patients with COPD. METHODS: A prospective cohort study including 2,268 patients with COPD was conducted in seven rural communities from May 2008 to May 2012. The relationships between the BODE (body mass index, airflow obstruction, dyspnea, and exercise capacity) index and depression and nicotine addiction were assessed...
February 2016: Iranian Journal of Public Health
Yanfeng Ren, Linong Ji, Yiming Mu, Tianpei Hong, Qiuhe Ji, Lixin Guo, Qin Huang, Xilin Yang
BACKGROUND: This study aimed to explore independent associations between serum uric acid (SUA) and hypoglycemia, and whether mildly increased SUA exacerbates the association between mild decline in estimated glomerular filtration rate (eGFR) and hypoglycemia. METHODS: A cross-sectional survey of 6713 inpatients with type 2 diabetes and eGFR ≥60 ml/min/1.73 m(2) and admitted to 81 tertiary care hospitals in China was conducted. Self-reported asymptotic hypoglycemia with plasma glucose ≤3...
April 19, 2016: Diabetes/metabolism Research and Reviews
Huilan Xu, Lulu Qin, Jinhong Wang, Liang Zhou, Dan Luo, Mi Hu, Zhenhua Li, Shuiyuan Xiao
OBJECTIVES: To identify risk factors, and their interactions, for suicidal ideation among the elderly in rural communities of Hunan and to provide some scientific basis for suicide prevention. DESIGN, SETTING AND PARTICIPANTS: A cross-sectional survey was conducted among the elderly in rural communities in China's Hunan Province. Thirteen areas were selected by multi-staged cluster random sampling, and 1887 rural elders were investigated via face-to-face interviews...
2016: BMJ Open
Sang-Soo Seo, Hea Young Oh, Jae-Kwan Lee, Ji-Sook Kong, Dong Ock Lee, Mi Kyung Kim
BACKGROUND & AIMS: Several food groups or dietary factors and the cervical microbiota may be involved in cervical carcinogenesis, but the evidence is not clear yet. We aimed to assess the association between dietary pattern and cervical intraepithelial neoplasia (CIN) and the combined effect of dietary pattern and cervical microbiome on the risk of CIN. METHODS: The cervical microbiota and diet assessed by pyrosequencing and a food-frequency questionnaire, respectively, of 65 women with CIN and 72 control women were used in this study...
March 31, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Qin Zhang, Yun-xing Liu, Li Cui, Shun-pin Li, Wei Gao, Gao-lin Hu, Zu-hui Zhang, Ya-jia Lan
OBJECTIVE: In determine the effect of heat shock protein 70-hom gene (hsp70-hom) polymorphism on the neurobehavioral function of workers exposed to vanadium. METHODS: Workers from the vanadium products and chemical industry were recruited by cluster sampling. Demographic data and exposure information were collected using a questionnaire. Neurobehavioral function was assessed by Neurobehavioral Core Test Battery. The hsp70-hom genotype was detected by restricted fragment length polymorphism-polymerase chain reaction (RFLP-PCR)...
January 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
Pan Zhang, Peian Lou, Guiqiu Chang, Peipei Chen, Lei Zhang, Ting Li, Cheng Qiao
BACKGROUND: Poor sleep quality and depression negatively impact the health-related quality of life of patients with type 2 diabetes, but the combined effect of the two factors is unknown. This study aimed to assess the interactive effects of poor sleep quality and depression on the quality of life in patients with type 2 diabetes. METHODS: Patients with type 2 diabetes (n = 944) completed the Diabetes Specificity Quality of Life scale (DSQL) and questionnaires on sleep quality and depression...
2016: BMC Family Practice
Qiang Zeng, Bin Zhou, Dong-Liang He, Yi-Xin Wang, Mu Wang, Pan Yang, Zhen Huang, Jin Li, Wen-Qing Lu
Exposure to trihalomethanes (THMs) and haloacetic acids (HAAs) has been individually associated with adverse male reproductive effects; however, their joint male reproductive toxicity is largely unknown. This study aimed to explore the joint effects of THMs and trichloroacetic acid (TCAA) on semen quality in a Chinese population. A total of 337 men presenting to the Reproductive Center of Tongjing Hospital, in Wuhan, China to seek semen analysis were included this study. Baseline blood THMs [chloroform (TCM), bromodichloromethane (BDCM), dibromochloromethane (DBCM), and bromoform (TBM)] and urinary TCAA were analyzed and dichotomized at their median levels...
May 2016: Environmental Pollution
H Li, M Zhao, Q Wang, L Liu, Y N Qi, J Y Li
BACKGROUND: Previous studies suggest a combined effect of insulin-like growth factor 1 (igf-1) and igf binding protein 3 (igfbp-3) gene polymorphisms, xenoestrogen, and phytoestrogen on the igf-1 signalling pathway and serum concentrations in the igf system, which are associated with premenopausal breast cancer (bca) risk. METHODS: Between 2010 and 2012, our study recruited 140 premenopausal bca patients and 160 community-based premenopausal control subjects. Participants were surveyed about oral contraceptive (oc) use, dietary habits, and other bca risk factors...
February 2016: Current Oncology
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