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https://www.readbyqxmd.com/read/28817493/dna-methylation-of-the-glucocorticoid-receptor-gene-promoter-in-the-placenta-is-associated-with-blood-pressure-regulation-in-human-pregnancy
#1
Sulistyo E Dwi Putra, Christoph Reichetzeder, Martin Meixner, Karsten Liere, Torsten Slowinski, Berthold Hocher
BACKGROUND: Blood pressure (BP) regulation during pregnancy is influenced by hormones of placental origin. It was shown that the glucocorticoid system is altered in hypertensive pregnancy disorders such as preeclampsia. Epigenetic mechanism might influence the activity of genes involved in placental hormone/hormone receptor synthesis/action during pregnancy. METHOD: In the current study, we analyzed the association of 5'-C-phosphate-G-3' (CpG) site methylation of different glucocorticoid receptor gene (NR3C1) promoter regions with BP during pregnancy...
August 16, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28816977/helicobacter-pylori-infection-atrophic-gastritis-and-pancreatic-cancer-risk-a-meta-analysis-of-prospective-epidemiologic-studies
#2
Hong Liu, Yue-Tong Chen, Rui Wang, Xin-Zu Chen
BACKGROUND: To investigate the associations of Helicobacter pylori (Hp) infection and atrophic gastritis (AG) with pancreatic cancer risk. METHODS: A literature search in PubMed was performed up to July 2017. Only prospective cohort and nested case-control studies enrolling cancer-free participants were eligible. Incident pancreatic cancer cases were ascertained during the follow-up. The risks of pancreatic cancer were compared between persons infected and noninfected with Hp, or between those with and without AG status at baseline...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28815800/a-method-for-data-driven-exploration-to-pinpoint-key-features-in-medical-data-and-facilitate-expert-review
#3
Kristina Juhlin, Kristina Star, G Niklas Norén
PURPOSE: To develop a method for data-driven exploration in pharmacovigilance and illustrate its use by identifying the key features of individual case safety reports related to medication errors. METHODS: We propose vigiPoint, a method that contrasts the relative frequency of covariate values in a data subset of interest to those within one or more comparators, utilizing odds ratios with adaptive statistical shrinkage. Nested analyses identify higher order patterns, and permutation analysis is employed to protect against chance findings...
August 16, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28815786/vitamin-d-intake-during-the-first-4-years-and-onset-of-asthma-by-age-5-a-nested-case-control-study
#4
Bright I Nwaru, Kishor Hadkhale, Niina Hämäläinen, Hanna-Mari Takkinen, Suvi Ahonen, Jorma Ilonen, Jorma Toppari, Onni Niemelä, Anna-Maija Haapala, Riitta Veijola, Mikael Knip, Suvi M Virtanen
BACKGROUND: Early life vitamin D intake has been linked to asthma risk in childhood, but the role of longitudinal vitamin D exposure has not been previously evaluated. We investigated the association between vitamin D intake during the first 4 years of life and asthma risk by age 5. METHODS: Within a Finnish population-based birth cohort, 182 incident asthma cases were matched to 728 controls on sex, genetic risk for type 1 diabetes, delivery hospital, and time of birth...
August 17, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28815700/pseudoangiosarcomatous-squamous-cell-carcinoma-of-the-skin-a-need-for-a-more-rigorous-nomenclature-for-histopathological-variants-of-squamous-cell-carcinoma
#5
Victoria Alegría-Landa, Francisco Jose Navarro-Triviño, Jose Aneiros-Fernandez, Luis Requena
Over the years, squamous cell carcinomas (SCC) that mimicked vascular lesions have been encompassed within different classifications and the underlying etiopathogenic mechanisms have been interpreted in different ways by different authors. Here, we present a case of SCC with pseudovascular areas in the right leg of a 96-year-old woman with chronic venous insufficiency. Histopathological examination closely resembled an angiosarcoma, but the immunohistochemical negativity for endothelial markers and the strong positivity for the pancytokeratin marker AE1/AE3 revealed the epithelial nature of the neoplasm...
August 16, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28815606/prospective-study-of-urinary-prostaglandin-e2-metabolite-and-pancreatic-cancer-risk
#6
Yong Cui, Xiao-Ou Shu, Hong-Lan Li, Gong Yang, Wanqing Wen, Yu-Tang Gao, Qiuyin Cai, Nathaniel Rothman, Hui-Yong Yin, Qing Lan, Yong-Bing Xiang, Wei Zheng
The cyclooxygenase 2 (COX-2) pathway is upregulated in many pancreatic cancer cells, and it is believed that carcinogenetic effects of COX2 upregulation are largely through prostaglandin E2 (PGE2) overproduction. We tested this hypothesis by evaluating the association between urinary PGE2 metabolites (PGE-M), a biomarker of in vivo PGE2 overproduction, and pancreatic cancer risk. We conducted a case-control study with 722 subjects (239 cases and 483 controls) nested within two prospective cohort studies, the Shanghai Women's Health Study (SWHS) and Shanghai Men's Health Study (SMHS)...
August 17, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28815579/-histological-characteristics-of-hpv-associated-and-independent-squamous-cell-carcinomas-of-the-vulva-a-study-of-1594-cases
#7
Natalia Rakislova, Omar Clavero, Laia Alemany, Adela Saco, Beatriz Quirós, Belen Lloveras, Maria Alejo, Michael Pawlita, Wim Quint, Marta Del Pino, Silvia de Sanjose, Jaume Ordi
There are at least two different etio-pathogenic pathways for the development of vulvar squamous cell carcinoma (VSCC): one associated with infection by human papillomavirus (HPV) and another independent of HPV. We aimed to describe the histological characteristics of HPV-associated and HPV-independent tumors and to determine the best strategy to identify HPV in VSCC. A single paraffin block was available for review from a series of 1594 VSCCs. In all cases HPV DNA detection was analyzed using the SPF10PCR/DEIA/LiPA25 system and p16 immunohistochemistry (IHC)...
August 17, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28814619/time-use-patterns-and-health-related-quality-of-life-in-adolescents
#8
Monica Wong, Tim Olds, Lisa Gold, Kate Lycett, Dorothea Dumuid, Josh Muller, Fiona K Mensah, David Burgner, John B Carlin, Ben Edwards, Terence Dwyer, Peter Azzopardi, Melissa Wake
OBJECTIVES: To describe 24-hour time-use patterns and their association with health-related quality of life (HRQoL) in early adolescence. METHODS: The Child Health CheckPoint was a cross-sectional study nested between Waves 6 and 7 of the Longitudinal Study of Australian Children. The participants were 1455 11- to 12-year-olds (39% of Wave 6; 51% boys). The exposure was 24-hour time use measured across 259 activities using the Multimedia Activity Recall for Children and Adolescents...
June 1, 2017: Pediatrics
https://www.readbyqxmd.com/read/28814486/serum-ghrelin-is-associated-with-risk-of-colorectal-adenocarcinomas-in-the-atbc-study
#9
Gwen Murphy, Amanda J Cross, Sanford M Dawsey, Frank Z Stanczyk, Farin Kamangar, Stephanie J Weinstein, Philip R Taylor, Satu Männistö, Demetrius Albanes, Christian C Abnet, Neal D Freedman
BACKGROUND: Colorectal cancers are the third most common cancers in women and men in the USA. While dietary and lifestyle factors such as Western diet, physical inactivity and obesity have been linked to an increased risk of this malignancy, the mechanisms for these associations are unclear. GI hormones, including ghrelin, are involved in energy balance by mediating appetite and metabolism; however, the association between ghrelin and colorectal cancer has not been studied. METHODS: We conducted a case-control study nested within the all-male Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study of Finnish smokers (aged 50-69 years) to examine serum ghrelin concentration and colorectal cancer risk...
August 16, 2017: Gut
https://www.readbyqxmd.com/read/28814381/impact-of-a-tutored-theoretical-practical-training-to-develop-undergraduate-students-skills-for-the-detection-of-caries-lesions-study-protocol-for-a-multicenter-controlled-randomized-study
#10
Mariana Minatel Braga, Tathiane Larissa Lenzi, Fernanda Rosche Ferreira, Fausto Medeiros Mendes, Daniela Prócida Raggio, José Carlos Imparato, Marcelo Bonecker, Ana Carolina Magalhães, Linda Wang, Daniela Rios, Juliano Pelim Pessan, Cristiane Duque, Maria Augusta Bessa Rebelo, Ary Oliveira Alves Filho, Marina De Deus Moura Lima, Marcoeli Silva Moura, Alessandro Diogo De Carli, Mariane Emi Sanabe, Maximiliano Sergio Cenci, Elenara Ferreira Oliveira, Marcos Britto Correa, Rachel Oliveira Rocha, Julio Eduardo Zenkner, Pedroza Uribe Murisí, Stefania Martignon, Juan Sebastian Lara, Fatima Gabriela Aquino, Alfredo Carrillo, Chun Hung Chu, Chris Deery, David Ricketts, Paulo Melo, José Leopoldo Ferreira Antunes, Kim Rud Ekstrand
BACKGROUND: Tutored laboratorial activities could be a manner of improving the competency development of students. However, its impact over conventional theoretical classes has not yet been tested. Additionally, different university contexts could influence this issue and should be explored. OBJECTIVE: To assess the impact of a tutored theoretical-practical training for teaching undergraduate students to detect caries lesions as compared with theoretical teaching activities...
August 16, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28814313/a-mixed-methods-study-of-hiv-related-services-in-buprenorphine-treatment
#11
Hannah K Knudsen, Jennifer Cook, Michelle R Lofwall, Sharon L Walsh, Jamie L Studts, Jennifer R Havens
BACKGROUND: Opioid use disorder (OUD) is a major risk factor in the acquisition and transmission of HIV. Clinical practice guidelines call for the integration of HIV services in OUD treatment. This mixed methods study describes the integration of HIV services in buprenorphine treatment and examines whether HIV services vary by prescribers' medical specialty and across practice settings. METHODS: Data were obtained via qualitative interviews with buprenorphine experts (n = 21) and mailed surveys from US buprenorphine prescribers (n = 1174)...
August 16, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28813433/diabetes-risks-and-outcomes-in-chronic-obstructive-pulmonary-disease-patients-two-nationwide-population-based-retrospective-cohort-studies
#12
Chao-Shun Lin, Chih-Chung Liu, Chun-Chieh Yeh, Yi-Cheng Chang, Chi-Li Chung, Hsin-Long Lane, Chun-Chuan Shih, Ta-Liang Chen, Chien-Chang Liao
OBJECTIVE: The relationship between chronic obstructive pulmonary disease (COPD) and diabetes remains incompletely understood. This study evaluated diabetes risk and post-diabetes outcomes in COPD patients with and without exacerbations. METHODS: We identified 4671 adults newly diagnosed with COPD exacerbations and 9342 adults newly diagnosed with COPD without exacerbations during 2000-2008 using Taiwan's National Health Insurance Research Database. A comparison cohort of 18684 adults without COPD, matched by age and sex, was randomly selected from the same dataset for the control group...
2017: PloS One
https://www.readbyqxmd.com/read/28813097/avian-communities-in-the-amazonian-cangas-vegetation-biogeographic-affinities-components-of-beta-diversity-and-conservation
#13
Sérgio H Borges, Marcos P D Santos, Leonardo M S Soares, Antonita S DA Silva
The Amazonian cangas is a vegetation type distributed as patches of open vegetation embedded in a matrix of tropical forest and that grows over iron-rich soils in the Serra dos Carajás region. To characterize cangas avifauna, we surveyed birds in eight patches varying from 43 to 1,366 hectares. Cangas avifauna has compositional affinities with savannas widespread throughout the Amazon and other biomes, and we estimate that more than 200 bird species occurs in this habitat. Species composition was relatively homogeneous, and the similarity among cangas patches was the dominant component of the beta-diversity...
August 14, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28812116/slco1b1-521t%C3%A2-%C3%A2-c-polymorphism-associated-with-rosuvastatin-induced-myotoxicity-in-chinese-coronary-artery-disease-patients-a-nested-case-control-study
#14
Ju-E Liu, Xiao-Ying Liu, Sheng Chen, Yan Zhang, Li-Yun Cai, Min Yang, Wei-Hua Lai, Bin Ren, Shi-Long Zhong
PURPOSE: This nested case-control study aimed to evaluate the association of candidate genetic variants with statin-induced myotoxicity in Chinese patients with coronary artery disease (CAD). METHODS: One hundred forty-eight Chinese patients experiencing statin-induced myotoxicity were included in our study, and 255 patients without muscular side effects served as controls. Five SNPs in CYP3A5, SLCO1B1, and APOE were genotyped. The effect of genetic variants on statin-induced myotoxicity was assessed...
August 15, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28811887/lessons-from-the-t%C3%A5-hoku-tsunami-a-model-for-island-avifauna-conservation-prioritization
#15
Michelle H Reynolds, Paul Berkowitz, John L Klavitter, Karen N Courtot
Earthquake-generated tsunamis threaten coastal areas and low-lying islands with sudden flooding. Although human hazards and infrastructure damage have been well documented for tsunamis in recent decades, the effects on wildlife communities rarely have been quantified. We describe a tsunami that hit the world's largest remaining tropical seabird rookery and estimate the effects of sudden flooding on 23 bird species nesting on Pacific islands more than 3,800 km from the epicenter. We used global positioning systems, tide gauge data, and satellite imagery to quantify characteristics of the Tōhoku earthquake-generated tsunami (11 March 2011) and its inundation extent across four Hawaiian Islands...
August 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28811652/sources-of-variability-in-childhood-obesity-indicators-and-related-behaviors
#16
P T Katzmarzyk, S T Broyles, J-P Chaput, M Fogelholm, G Hu, E V Lambert, C Maher, J Maia, T Olds, V Onywera, O L Sarmiento, M Standage, M S Tremblay, C Tudor-Locke
The purpose of this study was to describe sources of variability in obesity-related variables in 6022 children aged 9-11 y from 12 countries. The study design involved recruitment of students, nested within schools, which were nested within study sites. Height, weight and waist circumference (WC) were measured and BMI was calculated; sleep duration and total and in-school moderate-to-vigorous physical activity (MVPA) and sedentary time were measured by accelerometry; and diet scores were obtained by questionnaire...
August 16, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28811264/protein-coding-genes-as-hosts-for-noncoding-rna-expression
#17
REVIEW
Vincent Boivin, Gabrielle Deschamps-Francoeur, Michelle S Scott
With the emergence of high-throughput sequence characterization methods and the subsequent improvements in gene annotations, it is becoming increasingly clear that a large proportion of eukaryotic protein-coding genes (as many as 50% in human) serve as host genes for non-coding RNA genes. Amongst the most extensively characterized embedded non-coding RNA genes, small nucleolar RNAs and microRNAs represent abundant families. Encoded individually or clustered, in sense or antisense orientation with respect to their host and independently expressed or dependent on host expression, the genomic characteristics of embedded genes determine their biogenesis and the extent of their relationship with their host gene...
August 12, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28810980/risk-factors-for-rhabdomyolysis-in-the-u-s-army
#18
Owen T Hill, Dennis E Scofield, Jenna Usedom, Lakmini Bulathsinhala, Craig McKinnon, Paul Kwon, Timothy Haley, Robert Carter
The standardized mortality rate of rhabdomyolysis (RM) in Active Duty U.S. Army Soldiers is considerably higher than in the civilian population. RM occurs when large amounts of intracellular contents from damaged skeletal muscle escape into circulation, leading to serious sequelae (e.g., acute renal failure, hyperkalemia, compartment syndrome). Extended physical exertion, especially in hot environments, and trauma can precipitate RM. The aim of this study was to identify RM risk factors among U.S. Active Duty Army (ADA) Soldiers...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810979/women-veterans-a-population-at-risk-for-fibromyalgia-the-associations-between-fibromyalgia-symptoms-and-quality-of-life
#19
Rita F D'Aoust, Alicia Gill Rossiter, Amanda Elliott, Ming Ji, Cecile Lengacher, Maureen Groer
BACKGROUND: The Institute of Federal Health Care recently published an executive summary from a round table discussion indicating that active duty and retired female military personnel are at high risk for adverse health outcomes unique to military service including complications related to post-traumatic stress disorder (PTSD), unreported sexual trauma, and musculoskeletal problems. In 2008, the Institute of Medicine began to review, evaluate, and summarize the literature on health outcomes in Gulf War-deployed and found sufficient evidence of a causal relationship with PTSD and suggestive evidence of an association with fibromyalgia (FM)...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810942/psychosocial-maladjustment-at-student-and-classroom-level-as-indicators-of-peer-victimization
#20
Patrik Söderberg, Johan Korhonen, Kaj Björkqvist
The purpose of this study was to examine the role of aggressive behavior, anxiety, and peer rejection as multilevel indicators of peer victimization. A cross-sectional sample of 1,115 Finnish 9th grade students nested in 76 classrooms (mean age 15 years) were used to conduct multilevel models. All forms of psychosocial maladjustment, as well as student family economy, were found to predict peer victimization within classrooms. In addition, classrooms with more aggressive behavior and a higher proportion of rejected students suffered more peer victimization, beyond compositional effects of aggressive and rejected students being victimized...
August 15, 2017: Violence and Victims
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