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pediatric venous thromboembolism

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https://www.readbyqxmd.com/read/27861210/symptomatic-venous-thromboembolism-after-adolescent-knee-arthroscopy
#1
Robert F Murphy, Benton Heyworth, Dennis Kramer, Manahil Naqvi, Patricia E Miller, Yi-Meng Yen, Mininder S Kocher, Benjamin J Shore
BACKGROUND: The frequency of knee arthroscopy procedures is increasing in pediatric and adolescent patients. In general, complications after these procedures in adolescents are uncommon. The purposes of this study are to report the incidence of venous thromboembolism (VTE) in adolescent patients after knee arthroscopy procedures, as well identify risk factors in this patient population. METHODS: Medical records were reviewed in all pediatric and adolescent patients (≤19 y) who underwent an arthroscopic knee procedure from 2010 to 2014 and were diagnosed with a symptomatic VTE in the postoperative period...
November 17, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27850788/1151-implementing-a-venous-thromboembolism-prevention-program-in-the-pediatric-intensive-care-unit
#2
Beth Wathen, Pamela Reiter, Bryce Clark, Brian Branchford
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27820879/heparin-for-the-treatment-of-thrombosis-in-neonates
#3
REVIEW
Olga Romantsik, Matteo Bruschettini, Simona Zappettini, Luca Antonio Ramenghi, Maria Grazia Calevo
BACKGROUND: Among pediatric patients, newborns are at highest risk of developing thromboembolism. Neonatal thromboembolic (TE) events may consist of both venous and arterial thromboses and often iatrogenic complications (eg, central catheterization). Treatment guidelines for pediatric patients with TE events most often are extrapolated from the literature regarding adults. Options for the management of neonatal TE events include expectant management; nitroglycerin ointment; thrombolytic therapy or anticoagulant therapy, or a combination of the two; and surgery...
November 7, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27779597/abnormalities-in-fibrinolysis-at-the-time-of-admission-are-associated-with-dvt-mortality-and-disability-in-a-pediatric-trauma-population
#4
Christine M Leeper, Matthew D Neal, Christine McKenna, Jason Sperry, Barbara A Gaines
BACKGROUND: Abnormalities in fibrinolysis are common and associated with increased mortality in injured adults. While hyperfibrinolysis (HF) and fibrinolysis shutdown (SD) are potential prognostic indicators and treatment targets in adults, these derangements are not well-described in a pediatric trauma cohort. METHODS: Prospective analysis of highest level trauma activations age 0-18 presenting to our academic center between 6/1/2015-7/31/2016 with admission rapid thromboelastogram (TEG)...
October 25, 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27722126/venous-thromboembolism-in-pediatric-patients-a-single-institution-experience-in-korea
#5
Hyoung Soo Choi, Chang Won Choi, Heon Min Kim, Hye Won Park
BACKGROUND: While venous thromboembolism (VTE) is uncommon, its incidence is increasing in children. We aimed to evaluate the incidence, risk factors, treatment, and outcome of pediatric VTE cases at a single tertiary hospital in Korea. METHODS: We retrospectively analyzed the records of consecutive pediatric VTE patients admitted to the Seoul National University Bundang Hospital between April 2003 and March 2016. RESULTS: Among 70,462 hospitalizations, 25 pediatric VTE cases were identified (3...
September 2016: Blood Research
https://www.readbyqxmd.com/read/27639726/complications-following-spine-fusion-for-adolescent-idiopathic-scoliosis
#6
REVIEW
Robert F Murphy, James F Mooney
Complications following spine fusion for adolescent idiopathic scoliosis can be characterized as either intra-operative or post-operative. The most serious and feared complication is neurologic injury, both in the intra- and post-operative period. Other intra-operative complications include dural tears and ophthalmologic or peripheral nerve deficits, which may be related to positioning. Among the most common post-operative complications are surgical site infection, venous thromboembolism, gastrointestinal complications, and implant-related complications...
December 2016: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/27628011/venous-thromboembolic-disease-in-children-and-adolescents
#7
Vlad C Radulescu, John A D'Orazio
The VTE is mainly a disease of the older adult, though its incidence has increased significantly in the pediatric population over the past several years. This trend is likely due to enhanced awareness and recognition of VTE, as well as increased prevalence of thromboembolic associated risk factors, such as increases in the proportion of children with predisposing medical conditions. The evaluation and management of a child with VTE is similar to that of adults, however pediatric patients have their own distinct aspects of care, stemming from particularities of the hemostatic system, age-related risk factors and differences in response to anticoagulant and antithrombotic therapy...
September 15, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27545854/thrombosis-of-inferior-vena-cava-diagnosed-using-point-of-care-ultrasound-after-pediatric-near-syncope
#8
Shadi Lahham, Lester Tsai, Sean P Wilson, Samer Assaf, Roman Navarro, Faried Banimahd, Mohammad Subeh, Erik D Barton, Abigail Barbera, J Christian Fox
BACKGROUND: Venous thromboembolism (VTE) is extremely rare but under recognized in the pediatric population. Although the literature on the use of ultrasound to detect VTEs in adults is plentiful, little has been documented on its use in the pediatric population. CASE REPORT: We present a case of a healthy 16-year-old female who presented to our emergency department with 3 months of dyspnea on exertion and one episode of near-syncope. Point-of-care cardiac ultrasound identified an inferior vena cava thrombosis...
October 2016: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27539155/pediatric-thromboembolism-a-national-survey-in-japan
#9
Akira Ishiguro, Chibueze Chioma Ezinne, Nobuaki Michihata, Hisaya Nakadate, Atsushi Manabe, Masashi Taki, Midori Shima
Thromboembolism is being detected at increasing rates in pediatric tertiary care hospitals. The incidence of pediatric thrombophilia differs across countries, and is unknown in Japan. We sent a survey to 520 pediatric department heads and 629 specialists, requesting details on patients who developed symptomatic thromboembolism between 2006 and 2010. Of 280 eligible cases, congenital thrombophilia and other conditions were reported. Congenital thrombophilia (n = 54, 19.3 %) comprised defects in protein C (27), protein S (9), and antithrombin (7)...
August 18, 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/27514640/factors-influencing-act-after-intravenous-bolus-administration-of-100-iu-kg-of-unfractionated-heparin-during-cardiac-catheterization-in-children
#10
Ileana Muster, Thorsten Haas, Daniel Quandt, Oliver Kretschmar, Walter Knirsch
Anticoagulation using intravenous bolus administration of unfractionated heparin (UFH) aims to prevent thromboembolic complications in children undergoing cardiac catheterization (CC). Optimal UFH dosage is needed to reduce bleeding complications. We analyzed the effect of bolus UFH on activated clotting time (ACT) in children undergoing CC focusing on age-dependent, anesthesia-related, or disease-related influencing factors. This retrospective single-center study of 183 pediatric patients receiving UFH during CC analyzed ACT measured at the end of CC...
August 11, 2016: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/27496264/coagulation-profile-dynamics-in-pediatric-patients-with-cushing-syndrome-a-prospective-observational-comparative-study
#11
Leah Birdwell, Maya Lodish, Amit Tirosh, Prashant Chittiboina, Meg Keil, Charlampos Lyssikatos, Elena Belyavskaya, Richard A Feelders, Constantine A Stratakis
OBJECTIVE: To evaluate the association between Cushing syndrome and hypercoagulability in children. STUDY DESIGN: A prospective, observational study was performed of 54 patients with Cushing syndrome, 15.1 ± 3.9 years, treated at the National Institutes of Health Clinical Center. Coagulation profiles were taken before and 6-12 months after surgery and compared with18 normocortisolemic children, 13.7 ± 3.6 years. RESULTS: At baseline, patients with Cushing syndrome had greater levels of the procoagulant factor VIII (FVIII) vs controls (145 IU/dL ± 84 vs 99 ± 47, P = ...
October 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27262479/quality-improvement-program-reduces-venous-thromboembolism-in-infants-and-children-with-long-gap-esophageal-atresia-lgea
#12
Daniel P Kelly, Sigrid Bairdain, David Zurakowski, Brenda Dodson, Kathy M Harney, Russell W Jennings, Cameron C Trenor
PURPOSE: Patients with long-gap esophageal atresia (LGEA) treated with the Foker process are at increased risk of venous thromboembolism (VTE). An institutional quality improvement program to decrease VTE risk factor exposure and utilize prophylactic anticoagulation was implemented. We aim to evaluate the efficacy and safety of a VTE risk-reduction program in patients with LGEA. METHODS: Implementation and evaluation of a VTE risk-reduction program in patients with LGEA from 2012 to 2015 was performed...
July 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27161746/po-60-renal-tumors-with-extensive-vascular-disease-management-challenges-in-a-pediatric-series-from-the-hospital-for-sick-children
#13
G Zamperlini-Netto, A Zanette, E Wehbi, S Williams, R M Grant, L R Brandao
INTRODUCTION: Venous thrombotic events (VTE) are becoming more and more common in children, particularly in the hospital setting. To date, 1 in 200 children admitted to tertiary pediatric hospitals are now being recognized to develop VTE. Amongst those patients with an identified thrombotic occlusion, pediatric patients diagnosed with renal tumors have long been recognized, but their ideal management in the instances of vascular invasion remains controversial. AIM: We describe the clinical behavior of patients diagnosed with renal tumors and extra renal vascular involvement at The Hospital for Sick Children in Toronto, Canada...
April 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27128852/anti-coagulant-therapy-with-dabigatran-for-cystic-fibrosis-patients
#14
Manvi Bansal, Clement L Ren
Patients with cystic fibrosis (CF) are at increased risk of venous thromboembolism, especially in association with central venous catheter use. Coumarin drugs and low molecular weight heparin are frequently used for anti-coagulant therapy, but are more challenging to administer in CF patients. Dabigatran, an oral thrombin antagonist, is an alternative anti-coagulant medication, but its use in CF has not been reported. We describe our experience in successfully using dabigatran for long-term anti-coagulation therapy in two CF patients...
August 2016: Pediatric Pulmonology
https://www.readbyqxmd.com/read/27128820/prevalence-of-symptomatic-and-asymptomatic-thrombosis-in-pediatric-oncology-patients-with-tunneled-central-venous-catheters
#15
Reineke A Schoot, Marianne D van de Wetering, Theo Stijnen, Wim J E Tissing, Erna Michiels, Floor C H Abbink, Martine F Raphael, Hugo A Heij, Michel Zwaan, Jan A Lieverst, Hubert N Caron, Heleen van Ommen
BACKGROUND: Pediatric oncology patients with tunneled central venous catheters (CVCs) are at increased risk to develop venous thromboembolic events (VTEs), but the true prevalence of (a)symptomatic VTE is unknown. Aim of this study was to evaluate the prevalence of (a)symptomatic VTE in pediatric oncology patients with tunneled CVCs. PROCEDURE: All patients were included in the Aristocaths study: a randomized controlled multicenter trial investigating the prophylactic effect of 70% ethanol locks on CVC-associated bloodstream infections (CABSIs) were eligible for this study...
August 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27120553/predicting-venous-thromboembolism-in-pediatric-trauma-patients-reply
#16
Christopher R Connelly, Amy Laird, Jennifer M Watters
No abstract text is available yet for this article.
September 1, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27120405/predicting-venous-thromboembolism-in-pediatric-trauma-patients
#17
Piyush Kalakoti, Christina Notarianni, Anil Nanda
No abstract text is available yet for this article.
September 1, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27089461/venous-malformation-and-localized-intravascular-coagulopathy-in-children
#18
Judy W S Hung, Michael W Y Leung, Clarence S W Liu, Dickson H S Fung, W L Poon, Felix S D Yam, Yvonne C L Leung, Kenneth Lap Yan Chung, Paula M Y Tang, Nicholas S Y Chao, Kelvin K W Liu
Aim Localized intravascular coagulopathy (LIC) has been described in adults with venous malformation (VM) but rarely reported in children. This study aims to determine the prevalence of LIC in children with VM and associated risk factors. Methods Patients younger than 18 years with VM from 2010 to 2014 were reviewed. Diagnosis was confirmed by Doppler ultrasound and/or magnetic resonance imaging. Demographics data and VM characteristics including volume, site, extension, painful symptoms, and palpable phleboliths were studied...
April 18, 2016: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27053184/pediatric-thromboembolism-in-japan
#19
Kenichi Tetsuhara, Akira Ishiguro, Nobuaki Michihata, Sonoko Sensaki, Hisaya Nakadate, Yui Kimura, Daisuke Tomizawa, Kimikazu Matsumoto
OBJECTIVES: To investigate the clinical and epidemiologic characteristics of thromboembolism in Japanese children. METHODS: Clinical data of 77 patients with thromboembolism from a national tertiary pediatric care center were reviewed. RESULTS: Incidence of thromboembolism was calculated to be 15 per 10,000 hospital admissions. Infants younger than one year of age made up the largest age group (25 patients, including nine neonates younger than 30 d)...
October 2016: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/26963757/risk-factors-for-venous-thromboembolism-in-pediatric-trauma-patients-and-validation-of-a-novel-scoring-system-the-risk-of-clots-in-kids-with-trauma-score
#20
Jennifer Yen, Kyle J Van Arendonk, Michael B Streiff, LeAnn McNamara, F Dylan Stewart, Kim G Conner, Richard E Thompson, Elliott R Haut, Clifford M Takemoto
OBJECTIVES: Identify risk factors for venous thromboembolism and develop venous thromboembolism risk assessment models for pediatric trauma patients. DESIGN: Single institution and national registry retrospective cohort studies. SETTING: John Hopkins level 1 adult and pediatric trauma center and National Trauma Data Bank. PATIENTS: Patients 21 years and younger hospitalized following traumatic injuries at John Hopkins (1987-2011)...
May 2016: Pediatric Critical Care Medicine
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