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Neonatal pain

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https://www.readbyqxmd.com/read/29024833/health-of-vlbw-infants-in-germany-at-five-years-of-age-what-do-parents-describe
#1
Juliane Spiegler, Guido Stichtenoth, Inke R König, Egbert Herting, Wolfgang Göpel
BACKGROUND: There are only few data on medical problems and utilization of health services of former very low birth weight (VLBW) children at preschool age. STUDY DESIGN: At five years of age parents of a cohort of VLBW children (N=862) received questionnaires, a medical interview and examination. The results were compared to the KIGGS cohort (Deutscher-Kinder-und Jugendgesundheitssurvey, N=777). RESULTS: Parents of the VLBW and KIGGS cohort reported a very good or good health in 95% in their children...
October 9, 2017: Early Human Development
https://www.readbyqxmd.com/read/29020827/the-frequency-and-clinical-significance-of-intra-amniotic-inflammation-in-twin-pregnancies-with-preterm-labor-and-intact-membranes
#2
Kyung Joon Oh, Joon-Seok Hong, Roberto Romero, Bo Hyun Yoon
OBJECTIVE: The objective of this study is to evaluate the frequency and clinical significance of intra-amniotic inflammation in twin pregnancies with preterm labor and intact membranes. STUDY DESIGN: Amniotic fluid (AF) was retrieved from both sacs in 90 twin gestations with preterm labor and intact membranes (gestational age between 20 and 34 6/7 weeks). Preterm labor was defined as the presence of painful regular uterine contractions, with a frequency of at least 2 every 10 min, requiring hospitalization...
October 11, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29016499/epidural-analgesia-during-the-second-stage-of-labor-a-randomized-controlled-trial
#3
XiaoFeng Shen, Yunping Li, ShiQin Xu, Nan Wang, Sheng Fan, Xiang Qin, Chunxiu Zhou, Philip E Hess
OBJECTIVE: To evaluate whether maintaining a motor-sparing epidural analgesia infusion affects the duration of the second stage of labor in nulliparous parturients compared with a placebo control. METHODS: We conducted a double-blind, randomized, placebo-controlled trial involving nulliparous women with term cephalic singleton pregnancies who requested epidural analgesia. All women received epidural analgesia for the first stage of labor using 0.08% ropivacaine with 0...
October 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28977325/analysis-of-death-and-palliative-care-in-a-neonatal-intensive-care-unit
#4
Ligia Marçola, Silvia Maria Macedo de Barbosa, Ivete Zoboli, Rita Tiziana Verardo Polastrini, Maria Esther Jurfest Ceccon
OBJECTIVE: To characterize cases of children admitted to the Neonatal Intensive Care Unit of a tertiary university hospital who died in the period ranging from January 01, 2012 to July 31, 2014, and who required palliative care and/or were subjected to it. METHODS: A retrospective descriptive study was carried out by reviewing the medical records of these patients to collect data and to perform descriptive statistical analysis. RESULTS: During the study period, 49 children died after at least 48 hours from the time of admission...
April 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/28974458/docking-piglet-tails-how-much-does-it-hurt-and-for-how-long
#5
Pierpaolo Di Giminiani, Abozar Nasirahmadi, Emma M Malcolm, Matthew C Leach, Sandra A Edwards
Tail docking in pigs has the potential for evoking short- as well as long-term physiological and behavioural changes indicative of pain. Nonetheless, the existing scientific literature has thus far provided somewhat inconsistent data on the intensity and the duration of pain based on varying assessment methodologies and different post-procedural observation times. In this report we describe three response stages (immediate, short- and long-term) through the application of vocalisation, behavioural and nociceptive assessments in order to identify changes indicative of potential pain experienced by the piglets...
September 30, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28969315/alternative-technique-or-mitigating-strategy-for-sevoflurane-induced-neurodegeneration-a-randomized-controlled-dose-escalation-study-of-dexmedetomidine-in-neonatal-rats
#6
J-R Lee, E P Lin, R D Hofacer, B Upton, S Y Lee, L Ewing, B Joseph, A W Loepke
Background: Brain injury in newborn animals from prolonged anaesthetic exposure has raised concerns for millions of children undergoing anaesthesia every yr. Alternative anaesthetic techniques or mitigating strategies are urgently needed to ameliorate potentially harmful effects. We tested dexmedetomidine, both as a single agent alternative technique and as a mitigating adjuvant for sevoflurane anaesthesia. Methods: Neonatal rats were randomized to three injections of dexmedetomidine (5, 25, 50, or 100 µg kg -1 every 2 h), or 6 h of 2...
September 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28969013/low-dose-of-dexmedetomidine-as-an-adjuvant-to-bupivacaine-in-cesarean-surgery-provides-better-intraoperative-somato-visceral-sensory-block-characteristics-and-postoperative-analgesia
#7
Yong-Hong Bi, Xiao-Guang Cui, Rui-Qin Zhang, Chun-Yu Song, Yan-Zhuo Zhang
OBJECT: In this study, we aimed to investigate the beneficial effects of dexmedetomidine on somato-visceral sensory block characteristcs, postoperative analgesia and stress response of intrathecal bupivacaine administration in women undergoing cesarean section, and to find out which dose is better. METHODS: Sixty parturients with the American Society of Anesthesiologists (ASA) physical status I or II were anesthetized with intrathecal bupivacaine(10mg) alone or in combination with dexmedetomidine (3 μg and 5 μg) to undergo cesarean section...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28959897/procedural-pain-systematic-review-of-parent-experiences-and-information-needs
#8
Allison Gates, Kassi Shave, Robin Featherstone, Kelli Buckreus, Samina Ali, Shannon D Scott, Lisa Hartling
Parents wish to reduce their child's pain during medical procedures but may not know how to do so. We systematically reviewed the literature on parents' experiences and information needs related to managing their child's pain for common medical procedures. Of 2678 records retrieved through database searching, 5 were included. Three additional records were identified by scanning reference lists. Five studies were qualitative, and 3 were quantitative. Most took place in North America or Europe (n = 7) and described neonatal intensive care unit experiences (n = 5)...
September 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28959218/maternal-sensitivity-buffers-the-association-between-slc6a4-methylation-and-socio-emotional-stress-response-in-3-month-old-full-term-but-not-very-preterm-infants
#9
Livio Provenzi, Monica Fumagalli, Roberto Giorda, Francesco Morandi, Ida Sirgiovanni, Uberto Pozzoli, Fabio Mosca, Renato Borgatti, Rosario Montirosso
BACKGROUND: Very preterm (VPT) infants are hospitalized in Neonatal Intensive Care Units (NICUs) and are exposed to life-saving procedures eliciting pain-related stress. Recent research documented that pain-related stress might result in birth-to-discharge increased methylation of serotonin transporter gene (SLC6A4) in VPT infants, leading to poorer stress regulation at 3 months of age in VPT infants compared to their full-term (FT) counterparts. Maternal sensitivity is thought to support infants' stress response, but its role in moderating the effects of altered SLC6A4 methylation is unknown...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28958642/validation-of-greek-versions-of-the-neonatal-infant-pain-scale-and-premature-infant-pain-profile-in-neonatal-intensive-care-unit
#10
Christina Dionysakopoulou, Margarita Giannakopoulou, Loukia Liannou, Evangelos Bozas, Kirikas Zannikos, Vasiliki Matziou
The Neonatal Infant Pain Scale and the Premature Infant Pain Profile have been used widely in neonatal intensive care units for pain assessment. This study reports the evaluation and validation of these scales in full-term newborns who were hospitalized in two Greek neonatal intensive care units. Evaluation and validation of the Neonatal Infant Pain Scale and the Premature Infant Pain Profile in full-term newborns who were hospitalized in two Greek neonatal intensive care units. A cross-sectional study. Two neonatal intensive care units at a large General Children's Hospital in Greece...
September 22, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/28956768/differentiated-sh-sy5y-human-cells-provide-a-reductionist-model-of-hsv-1-neurotropism
#11
Mackenzie M Shipley, Colleen A Mangold, Chad V Kuny, Moriah L Szpara
Neuron-virus interactions that occur during herpes simplex virus (HSV) infection are not fully understood. Neurons are the site of lifelong latency and are a crucial target for long-term suppressive therapy or viral clearance. A reproducible neuronal model of human origin would facilitate studies of HSV and other neurotropic viruses. Current neuronal models in the herpesvirus field vary widely and have caveats including incomplete differentiation, non-human origins, or the use of dividing cells that have neuropotential, but lack neuronal morphology...
September 27, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28954564/maternal-and-neonatal-outcomes-among-pregnant-women-with-fibromyalgia-a-population-based-study-of-12-million-births
#12
Glenda Gatan Magtanong, Andrea R Spence, Nicholas Czuzoj-Shulman, Haim Arie Abenhaim
PURPOSE: Fibromyalgia (FM) is a rheumatologic disorder marked by chronic, widespread pain and associated comorbid conditions. The purpose of our study was to evaluate the effect of FM on maternal and neonatal outcomes. METHODS: Using the Healthcare Cost and Utilization Project Nationwide Inpatient Sample from 1999 to 2013, we conducted a population-based retrospective cohort study consisting of women who delivered during that period. Logistic regression was used to compare maternal and neonatal outcomes among pregnancies in women with and without FM...
September 27, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28950826/long-term-effects-of-early-exposure-to-stress-pain-opioids-and-anaesthetics-on-pain-sensitivity-and-neurocognition
#13
Gerbrich E van den Bosch, Monique van Dijk, Dick Tibboel, Jurgen C de Graaff
Background Experimental studies have shown that neonatal exposure to stress, pain, opioids and anaesthetics may cause histologic and morphologic changes in the central nervous system with associated functional and behavioural changes in the long term. An important question is whether this holds true for humans also - and in particular for sick neonates who often are exposed to pain and receive anaesthetics and sedatives. Methods In this narrative review, we evaluate the effects of neonatal exposure to stress, pain, opioids and anaesthetics in infancy and childhood in animals and in preterm born and term born humans on pain sensitivity, brain morphology, cognition and behaviour later in life...
September 26, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28950825/therapeutic-drug-monitoring-in-neonates-what-makes-them-unique
#14
P Mian, R B Flint, D Tibboel, J N van den Anker, K Allegaert, B C P Koch
Therapeutic drug monitoring (TDM) refers to the interpretation of quantified drug concentrations in strategically timed samples of bodily fluids, with the aim to maximize therapeutic benefit, while minimizing toxicity. In essence, TDM criteria for neonates are similar to those for adults, but specific issues should be considered. This review focusses on the relevance of these specific issues: larger variability in pharmacokinetics (PK), and non-PK related factors, sampling opportunities, analytical techniques, therapeutic range...
September 26, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28937705/interventions-for-treating-genital-chlamydia-trachomatis-infection-in-pregnancy
#15
REVIEW
Catherine Cluver, Natalia Novikova, David Oa Eriksson, Kevin Bengtsson, Göran K Lingman
BACKGROUND: Genital Chlamydia trachomatis (C.trachomatis) infection may lead to pregnancy complications such as miscarriage, preterm labour, low birthweight, preterm rupture of membranes, increased perinatal mortality, postpartum endometritis, chlamydial conjunctivitis and C.trachomatis pneumonia.This review supersedes a previous review on this topic. OBJECTIVES: To establish the most efficacious and best-tolerated therapy for treatment of genital chlamydial infection in preventing maternal infection and adverse neonatal outcomes...
September 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28933267/neonatal-plasticity-of-the-nociceptive-system-mechanisms-effects-and-treatment-of-repetitive-painful-procedures-during-nicu-admittance
#16
N J Van den Hoogen, J Patijn, D Tibboel, E A Joosten
INTRODUCTION: In Neonatal Intensive Care Unit (NICU), prematurely born infants undergo a range of skin breaking and painful procedures. At the same time, the spinal nociceptive system is in a sensitive developmental stage. Both neonatal repetitive painful procedures and their treatment can induce plasticity of the neonatal spinal nociceptive system, causing long-lasting alterations to pain processing and pain reactivity. METHODS: This review focuses on developmental processes related to the nociceptive network in the spinal dorsal horn and more specifically at mechanisms related to 1...
September 21, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28933266/intravenous-paracetamol-dosing-guidelines-for-pain-management-in-pre-term-neonates-using-the-paediatric-study-decision-tree
#17
P Mian, C A J Knibbe, E A M Calvier, D Tibboel, K Allegaert
BACKGROUND: Intravenous paracetamol (acetaminophen) has not been licensed for analgesia in preterm neonates or infants < 2 years, respectively, in Europe and the United States. A variety of dosing regimens is therefore used off-label. Because evidence supports the use of the same target mean steady state paracetamol concentration (Cssmean, 9-11 mg/L) for pain relief in neonates compared to older children and adults, dosing regimens based on this Cssmean were evaluated in a two-step approach...
September 21, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28928911/prediction-of-low-birth-weight-delivery-by-maternal-status-and-its-validation-decision-curve-analysis
#18
Mehri Rejali, Marjan Mansourian, Zohre Babaei, Babak Eshrati
BACKGROUND: In this study, we evaluated assessed elements connected with low birth weight (LBW) and used decision curve analysis (DCA) to define a scale to anticipate the probability of having a LBW newborn child. METHODS: This hospital-based case-control study was led in Arak Hospital in Iran. The study included 470 mothers with LBW neonate and 470 mothers with natural neonates. Information were gathered by meeting moms utilizing preplanned organized questionnaire and from hospital records...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28925559/persistent-pain-in-neonates-challenges-in-assessment-without-the-aid-of-a-clinical-tool
#19
Elaine M Boyle, Joanna Bradshaw, Kathryn I Blake
AIM: Evaluation of comfort and pain in neonates is important for management. Specific signs of persistent pain in neonates remain undefined; few validated clinical tools assess persistent pain. We sought to determine (i) difficulty perceived by staff and parents in assessing comfort/persistent pain in babies, (ii) strategies employed when no clinical tool is used and (iii) variation between clinicians' assessments. METHODS: Parent and staff questionnaires addressed difficulty in assessing pain/comfort in neonates and strategies used in making assessments...
September 19, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28920044/effect-of-multisensory-stimulation-on-pain-of-eye-examination-in-preterm-infants
#20
Hossein Zeraati, Javad Shahinfar, Hamidreza Behnam Vashani, Tayebeh Reyhani
BACKGROUND: Eye examination as one of the painful procedures for retinopathy of prematurity screening can cause some pain-related physiological and behavioral changes in preterm infants. Multisensory stimulation is an analgesic non-pharmacological method that has analgesic effects on infants during painful procedures. OBJECTIVES: This study aimed to determine the effect of multisensory stimulation on induced pain during eye examination for retinopathy of prematurity screening in preterm infants...
February 2017: Anesthesiology and Pain Medicine
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